-- dump date 20140619_130311 -- class Genbank::misc_feature -- table misc_feature_note -- id note 297245000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 297245000002 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 297245000003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 297245000004 Magnesium ion binding site [ion binding]; other site 297245000005 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 297245000006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245000007 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 297245000008 Ubiquitin-like proteins; Region: UBQ; cl00155 297245000009 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 297245000010 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 297245000011 ATP binding site [chemical binding]; other site 297245000012 substrate interface [chemical binding]; other site 297245000013 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 297245000014 active site residue [active] 297245000015 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 297245000016 YcaO-like family; Region: YcaO; pfam02624 297245000017 TfuA-like protein; Region: TfuA; pfam07812 297245000018 Global regulator protein family; Region: CsrA; pfam02599 297245000019 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 297245000020 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 297245000021 TraL protein; Region: TraL; pfam07178 297245000022 type IV conjugative transfer system protein TraE; Region: TraE_TIGR; TIGR02761 297245000023 TraK protein; Region: TraK; pfam06586 297245000024 type-F conjugative transfer system secretin TraK; Region: TraK_Ftype; TIGR02756 297245000025 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 297245000026 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 297245000027 Similar to conjugative transfer protein TraV;hypothetical protein 297245000028 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 297245000029 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 297245000030 Domain of unknown function DUF87; Region: DUF87; pfam01935 297245000031 type-F conjugative transfer system protein TrbI; Region: TrbI_Ftype; TIGR02744 297245000032 type-F conjugative transfer system protein TraW; Region: TraW; TIGR02743 297245000033 TraU protein; Region: TraU; cl06067 297245000034 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 297245000035 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 297245000036 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 297245000037 F plasmid transfer operon protein; Region: TraF; pfam13728 297245000038 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 297245000039 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 297245000040 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 297245000041 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 297245000042 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 297245000043 F sex factor protein N terminal; Region: TraD_N; pfam12615 297245000044 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 297245000045 Walker A motif; other site 297245000046 ATP binding site [chemical binding]; other site 297245000047 Walker B motif; other site 297245000048 TrwC relaxase; Region: TrwC; pfam08751 297245000049 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 297245000050 AAA domain; Region: AAA_30; pfam13604 297245000051 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 297245000052 YcfA-like protein; Region: YcfA; pfam07927 297245000053 Cupin domain; Region: Cupin_2; cl17218 297245000054 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 297245000055 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 297245000056 Uncharacterized conserved protein [Function unknown]; Region: COG2128 297245000057 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 297245000058 multiple promoter invertase; Provisional; Region: mpi; PRK13413 297245000059 catalytic residues [active] 297245000060 catalytic nucleophile [active] 297245000061 Presynaptic Site I dimer interface [polypeptide binding]; other site 297245000062 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 297245000063 Synaptic Flat tetramer interface [polypeptide binding]; other site 297245000064 Synaptic Site I dimer interface [polypeptide binding]; other site 297245000065 DNA binding site [nucleotide binding] 297245000066 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 297245000067 DNA-binding interface [nucleotide binding]; DNA binding site 297245000068 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 297245000069 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 297245000070 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 297245000071 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 297245000072 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 297245000073 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 297245000074 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 297245000075 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 297245000076 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 297245000077 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 297245000078 DNA-binding interface [nucleotide binding]; DNA binding site 297245000079 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 297245000080 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 297245000081 active site 297245000082 DNA binding site [nucleotide binding] 297245000083 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 297245000084 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 297245000085 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 297245000086 Catalytic site [active] 297245000087 Uncharacterized conserved protein [Function unknown]; Region: COG2135 297245000088 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 297245000089 DnaA N-terminal domain; Region: DnaA_N; pfam11638 297245000090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245000091 Walker A motif; other site 297245000092 ATP binding site [chemical binding]; other site 297245000093 Walker B motif; other site 297245000094 arginine finger; other site 297245000095 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 297245000096 DnaA box-binding interface [nucleotide binding]; other site 297245000097 DNA polymerase III subunit beta; Validated; Region: PRK05643 297245000098 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 297245000099 putative DNA binding surface [nucleotide binding]; other site 297245000100 dimer interface [polypeptide binding]; other site 297245000101 beta-clamp/clamp loader binding surface; other site 297245000102 beta-clamp/translesion DNA polymerase binding surface; other site 297245000103 recombination protein F; Reviewed; Region: recF; PRK00064 297245000104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245000105 Walker A/P-loop; other site 297245000106 ATP binding site [chemical binding]; other site 297245000107 Q-loop/lid; other site 297245000108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245000109 ABC transporter signature motif; other site 297245000110 Walker B; other site 297245000111 D-loop; other site 297245000112 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 297245000113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245000114 Mg2+ binding site [ion binding]; other site 297245000115 G-X-G motif; other site 297245000116 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 297245000117 anchoring element; other site 297245000118 dimer interface [polypeptide binding]; other site 297245000119 ATP binding site [chemical binding]; other site 297245000120 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 297245000121 active site 297245000122 putative metal-binding site [ion binding]; other site 297245000123 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 297245000124 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 297245000125 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 297245000126 arginine decarboxylase; Provisional; Region: PRK05354 297245000127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 297245000128 dimer interface [polypeptide binding]; other site 297245000129 active site 297245000130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 297245000131 catalytic residues [active] 297245000132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 297245000133 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 297245000134 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 297245000135 putative active site; other site 297245000136 catalytic triad [active] 297245000137 putative dimer interface [polypeptide binding]; other site 297245000138 bacterial Hfq-like; Region: Hfq; cd01716 297245000139 hexamer interface [polypeptide binding]; other site 297245000140 Sm1 motif; other site 297245000141 RNA binding site [nucleotide binding]; other site 297245000142 Sm2 motif; other site 297245000143 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 297245000144 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 297245000145 HflX GTPase family; Region: HflX; cd01878 297245000146 G1 box; other site 297245000147 GTP/Mg2+ binding site [chemical binding]; other site 297245000148 Switch I region; other site 297245000149 G2 box; other site 297245000150 G3 box; other site 297245000151 Switch II region; other site 297245000152 G4 box; other site 297245000153 G5 box; other site 297245000154 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 297245000155 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 297245000156 catalytic residues [active] 297245000157 Pirin; Region: Pirin; pfam02678 297245000158 Pirin-related protein [General function prediction only]; Region: COG1741 297245000159 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 297245000160 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 297245000161 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 297245000162 active site 297245000163 nucleophile elbow; other site 297245000164 Patatin phospholipase; Region: DUF3734; pfam12536 297245000165 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 297245000166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245000167 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245000168 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 297245000169 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 297245000170 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 297245000171 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 297245000172 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 297245000173 active site 297245000174 Zn binding site [ion binding]; other site 297245000175 hypothetical protein; Provisional; Region: PRK05255 297245000176 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 297245000177 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 297245000178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245000179 Methyltransferase domain; Region: Methyltransf_26; pfam13659 297245000180 Protein of unknown function (DUF962); Region: DUF962; cl01879 297245000181 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 297245000182 amino acid transporter; Region: 2A0306; TIGR00909 297245000183 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 297245000184 Phosphate transporter family; Region: PHO4; pfam01384 297245000185 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 297245000186 diiron binding motif [ion binding]; other site 297245000187 PAS domain; Region: PAS_9; pfam13426 297245000188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245000189 putative active site [active] 297245000190 heme pocket [chemical binding]; other site 297245000191 PAS domain S-box; Region: sensory_box; TIGR00229 297245000192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245000193 putative active site [active] 297245000194 heme pocket [chemical binding]; other site 297245000195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245000196 PAS domain; Region: PAS_9; pfam13426 297245000197 putative active site [active] 297245000198 heme pocket [chemical binding]; other site 297245000199 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245000200 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245000201 metal binding site [ion binding]; metal-binding site 297245000202 active site 297245000203 I-site; other site 297245000204 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245000205 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 297245000206 Peptidase family M28; Region: Peptidase_M28; pfam04389 297245000207 active site 297245000208 metal binding site [ion binding]; metal-binding site 297245000209 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 297245000210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245000211 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245000212 substrate binding pocket [chemical binding]; other site 297245000213 membrane-bound complex binding site; other site 297245000214 hinge residues; other site 297245000215 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245000216 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245000217 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 297245000218 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 297245000219 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 297245000220 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 297245000221 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 297245000222 trimer interface [polypeptide binding]; other site 297245000223 active site 297245000224 substrate binding site [chemical binding]; other site 297245000225 CoA binding site [chemical binding]; other site 297245000226 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 297245000227 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 297245000228 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 297245000229 Predicted membrane protein [Function unknown]; Region: COG2323 297245000230 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 297245000231 tetramer interface [polypeptide binding]; other site 297245000232 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 297245000233 active site 297245000234 Mg2+/Mn2+ binding site [ion binding]; other site 297245000235 Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981 297245000236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245000237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245000238 LysR substrate binding domain; Region: LysR_substrate; pfam03466 297245000239 dimerization interface [polypeptide binding]; other site 297245000240 putative active site [active] 297245000241 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 297245000242 Radial spokehead-like protein; Region: Radial_spoke; pfam04712 297245000243 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 297245000244 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 297245000245 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 297245000246 DNA binding residues [nucleotide binding] 297245000247 dimer interface [polypeptide binding]; other site 297245000248 mercury binding site [ion binding]; other site 297245000249 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 297245000250 Predicted membrane protein [Function unknown]; Region: COG3428 297245000251 HipA protein, DNA binding regulator 297245000252 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 297245000253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245000254 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 297245000255 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 297245000256 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 297245000257 active site 297245000258 DNA binding site [nucleotide binding] 297245000259 Int/Topo IB signature motif; other site 297245000260 Predicted transcriptional regulator [Transcription]; Region: COG5340 297245000261 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 297245000262 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 297245000263 Helix-turn-helix domain; Region: HTH_17; pfam12728 297245000264 Domain of unknown function (DUF927); Region: DUF927; pfam06048 297245000265 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 297245000266 putative active site [active] 297245000267 putative NTP binding site [chemical binding]; other site 297245000268 putative nucleic acid binding site [nucleotide binding]; other site 297245000269 aspartate aminotransferase; Provisional; Region: PRK05764 297245000270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 297245000271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245000272 homodimer interface [polypeptide binding]; other site 297245000273 catalytic residue [active] 297245000274 excinuclease ABC subunit B; Provisional; Region: PRK05298 297245000275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245000276 ATP binding site [chemical binding]; other site 297245000277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245000278 nucleotide binding region [chemical binding]; other site 297245000279 ATP-binding site [chemical binding]; other site 297245000280 Ultra-violet resistance protein B; Region: UvrB; pfam12344 297245000281 UvrB/uvrC motif; Region: UVR; pfam02151 297245000282 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245000283 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245000284 metal binding site [ion binding]; metal-binding site 297245000285 active site 297245000286 I-site; other site 297245000287 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245000288 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 297245000289 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 297245000290 active site 297245000291 FMN binding site [chemical binding]; other site 297245000292 substrate binding site [chemical binding]; other site 297245000293 3Fe-4S cluster binding site [ion binding]; other site 297245000294 Cell division protein ZapA; Region: ZapA; pfam05164 297245000295 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 297245000296 proline aminopeptidase P II; Provisional; Region: PRK10879 297245000297 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 297245000298 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 297245000299 active site 297245000300 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 297245000301 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 297245000302 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 297245000303 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 297245000304 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 297245000305 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 297245000306 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 297245000307 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 297245000308 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 297245000309 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245000310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245000311 substrate binding pocket [chemical binding]; other site 297245000312 membrane-bound complex binding site; other site 297245000313 hinge residues; other site 297245000314 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 297245000315 ribonuclease R; Region: RNase_R; TIGR02063 297245000316 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 297245000317 RNB domain; Region: RNB; pfam00773 297245000318 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 297245000319 RNA binding site [nucleotide binding]; other site 297245000320 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 297245000321 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 297245000322 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 297245000323 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 297245000324 tetramer (dimer of dimers) interface [polypeptide binding]; other site 297245000325 active site 297245000326 dimer interface [polypeptide binding]; other site 297245000327 5' nucleotidase family; Region: 5_nucleotid; cl17687 297245000328 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 297245000329 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 297245000330 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 297245000331 PhnA protein; Region: PhnA; pfam03831 297245000332 Response regulator receiver domain; Region: Response_reg; pfam00072 297245000333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245000334 active site 297245000335 phosphorylation site [posttranslational modification] 297245000336 intermolecular recognition site; other site 297245000337 DNA polymerase I; Provisional; Region: PRK05755 297245000338 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 297245000339 active site 297245000340 metal binding site 1 [ion binding]; metal-binding site 297245000341 putative 5' ssDNA interaction site; other site 297245000342 metal binding site 3; metal-binding site 297245000343 metal binding site 2 [ion binding]; metal-binding site 297245000344 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 297245000345 putative DNA binding site [nucleotide binding]; other site 297245000346 putative metal binding site [ion binding]; other site 297245000347 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 297245000348 active site 297245000349 catalytic site [active] 297245000350 substrate binding site [chemical binding]; other site 297245000351 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 297245000352 active site 297245000353 DNA binding site [nucleotide binding] 297245000354 catalytic site [active] 297245000355 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 297245000356 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 297245000357 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 297245000358 trimer interface [polypeptide binding]; other site 297245000359 active site 297245000360 UDP-GlcNAc binding site [chemical binding]; other site 297245000361 lipid binding site [chemical binding]; lipid-binding site 297245000362 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 297245000363 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 297245000364 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 297245000365 dimer interface [polypeptide binding]; other site 297245000366 active site 297245000367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245000368 Coenzyme A binding pocket [chemical binding]; other site 297245000369 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 297245000370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245000371 Coenzyme A binding pocket [chemical binding]; other site 297245000372 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 297245000373 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 297245000374 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 297245000375 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 297245000376 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 297245000377 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 297245000378 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 297245000379 substrate binding pocket [chemical binding]; other site 297245000380 substrate-Mg2+ binding site; other site 297245000381 aspartate-rich region 1; other site 297245000382 aspartate-rich region 2; other site 297245000383 Similar to predicted signal transduction protein, truncated;hypothetical protein 297245000384 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 297245000385 tetramer interface [polypeptide binding]; other site 297245000386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245000387 catalytic residue [active] 297245000388 YCII-related domain; Region: YCII; cl00999 297245000389 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 297245000390 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 297245000391 tetramer interface [polypeptide binding]; other site 297245000392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245000393 catalytic residue [active] 297245000394 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 297245000395 lipoyl attachment site [posttranslational modification]; other site 297245000396 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 297245000397 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 297245000398 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 297245000399 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245000400 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 297245000401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245000402 dimer interface [polypeptide binding]; other site 297245000403 conserved gate region; other site 297245000404 putative PBP binding loops; other site 297245000405 ABC-ATPase subunit interface; other site 297245000406 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 297245000407 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 297245000408 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 297245000409 Walker A/P-loop; other site 297245000410 ATP binding site [chemical binding]; other site 297245000411 Q-loop/lid; other site 297245000412 ABC transporter signature motif; other site 297245000413 Walker B; other site 297245000414 D-loop; other site 297245000415 H-loop/switch region; other site 297245000416 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 297245000417 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 297245000418 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 297245000419 catalytic residues [active] 297245000420 hinge region; other site 297245000421 alpha helical domain; other site 297245000422 Cytochrome c553 [Energy production and conversion]; Region: COG2863 297245000423 Cytochrome c; Region: Cytochrom_C; cl11414 297245000424 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 297245000425 G1 box; other site 297245000426 GTP/Mg2+ binding site [chemical binding]; other site 297245000427 Switch I region; other site 297245000428 G2 box; other site 297245000429 G3 box; other site 297245000430 Switch II region; other site 297245000431 G4 box; other site 297245000432 G5 box; other site 297245000433 acetyl-CoA synthetase; Provisional; Region: PRK00174 297245000434 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 297245000435 active site 297245000436 CoA binding site [chemical binding]; other site 297245000437 acyl-activating enzyme (AAE) consensus motif; other site 297245000438 AMP binding site [chemical binding]; other site 297245000439 acetate binding site [chemical binding]; other site 297245000440 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 297245000441 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 297245000442 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 297245000443 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 297245000444 tetrameric interface [polypeptide binding]; other site 297245000445 NAD binding site [chemical binding]; other site 297245000446 catalytic residues [active] 297245000447 Dodecin; Region: Dodecin; cl01328 297245000448 dihydrodipicolinate reductase; Provisional; Region: PRK00048 297245000449 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 297245000450 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 297245000451 ProQ/FINO family; Region: ProQ; smart00945 297245000452 putative RNA binding sites [nucleotide binding]; other site 297245000453 MltA specific insert domain; Region: MltA; cl08398 297245000454 pyruvate kinase; Provisional; Region: PRK05826 297245000455 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 297245000456 domain interfaces; other site 297245000457 active site 297245000458 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 297245000459 Phosphoglycerate kinase; Region: PGK; pfam00162 297245000460 substrate binding site [chemical binding]; other site 297245000461 hinge regions; other site 297245000462 ADP binding site [chemical binding]; other site 297245000463 catalytic site [active] 297245000464 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 297245000465 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 297245000466 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 297245000467 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 297245000468 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 297245000469 TPP-binding site [chemical binding]; other site 297245000470 dimer interface [polypeptide binding]; other site 297245000471 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 297245000472 PYR/PP interface [polypeptide binding]; other site 297245000473 dimer interface [polypeptide binding]; other site 297245000474 TPP binding site [chemical binding]; other site 297245000475 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 297245000476 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 297245000477 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 297245000478 active site 297245000479 Zn binding site [ion binding]; other site 297245000480 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 297245000481 DNA cytosine methylase; Provisional; Region: PRK10458 297245000482 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 297245000483 cofactor binding site; other site 297245000484 DNA binding site [nucleotide binding] 297245000485 substrate interaction site [chemical binding]; other site 297245000486 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 297245000487 additional DNA contacts [nucleotide binding]; other site 297245000488 mismatch recognition site; other site 297245000489 active site 297245000490 zinc binding site [ion binding]; other site 297245000491 DNA intercalation site [nucleotide binding]; other site 297245000492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245000493 sequence-specific DNA binding site [nucleotide binding]; other site 297245000494 salt bridge; other site 297245000495 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 297245000496 Catalytic site [active] 297245000497 Global regulator protein family; Region: CsrA; pfam02599 297245000498 TrbC/VIRB2 family; Region: TrbC; pfam04956 297245000499 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 297245000500 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 297245000501 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 297245000502 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 297245000503 Type IV secretion system proteins; Region: T4SS; pfam07996 297245000504 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 297245000505 VirB8 protein; Region: VirB8; pfam04335 297245000506 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 297245000507 VirB7 interaction site; other site 297245000508 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 297245000509 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 297245000510 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 297245000511 Walker A motif; other site 297245000512 hexamer interface [polypeptide binding]; other site 297245000513 ATP binding site [chemical binding]; other site 297245000514 Walker B motif; other site 297245000515 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 297245000516 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 297245000517 Walker A motif; other site 297245000518 ATP binding site [chemical binding]; other site 297245000519 Walker B motif; other site 297245000520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245000521 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 297245000522 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 297245000523 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 297245000524 Fatty acid desaturase; Region: FA_desaturase; pfam00487 297245000525 Di-iron ligands [ion binding]; other site 297245000526 Transposase; Region: DDE_Tnp_ISL3; pfam01610 297245000527 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 297245000528 MobA/MobL family; Region: MobA_MobL; pfam03389 297245000529 AAA domain; Region: AAA_30; pfam13604 297245000530 Family description; Region: UvrD_C_2; pfam13538 297245000531 Conjugal transfer protein TraD; Region: TraD; pfam06412 297245000532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245000533 S-adenosylmethionine binding site [chemical binding]; other site 297245000534 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 297245000535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 297245000536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245000537 non-specific DNA binding site [nucleotide binding]; other site 297245000538 salt bridge; other site 297245000539 sequence-specific DNA binding site [nucleotide binding]; other site 297245000540 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 297245000541 Catalytic site [active] 297245000542 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 297245000543 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 297245000544 Int/Topo IB signature motif; other site 297245000545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245000546 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 297245000547 Walker A motif; other site 297245000548 ATP binding site [chemical binding]; other site 297245000549 Walker B motif; other site 297245000550 Nuclease-related domain; Region: NERD; pfam08378 297245000551 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 297245000552 DNA protecting protein DprA; Region: dprA; TIGR00732 297245000553 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 297245000554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245000555 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 297245000556 Transposase; Region: HTH_Tnp_1; pfam01527 297245000557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 297245000558 putative transposase OrfB; Reviewed; Region: PHA02517 297245000559 HTH-like domain; Region: HTH_21; pfam13276 297245000560 Integrase core domain; Region: rve; pfam00665 297245000561 Integrase core domain; Region: rve_3; pfam13683 297245000562 Similar to C-terminal part of type I restriction enzyme;hypothetical protein 297245000563 Similar to C-terminal part of predicted nuclease;hypothetical protein 297245000564 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 297245000565 active site 297245000566 NTP binding site [chemical binding]; other site 297245000567 nucleic acid binding site [nucleotide binding]; other site 297245000568 Transposase domain (DUF772); Region: DUF772; pfam05598 297245000569 Similar to predicted nuclease, truncated;hypothetical protein 297245000570 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 297245000571 Fic/DOC family; Region: Fic; pfam02661 297245000572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245000573 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 297245000574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 297245000575 Transposase; Region: DDE_Tnp_ISL3; pfam01610 297245000576 Transposase; Region: HTH_Tnp_1; pfam01527 297245000577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 297245000578 putative transposase OrfB; Reviewed; Region: PHA02517 297245000579 HTH-like domain; Region: HTH_21; pfam13276 297245000580 Integrase core domain; Region: rve; pfam00665 297245000581 Integrase core domain; Region: rve_2; pfam13333 297245000582 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 297245000583 TraI gene fragment;hypothetical protein 297245000584 TraI gene fragment;hypothetical protein 297245000585 TraI gene fragment;hypothetical protein 297245000586 Similar to transposase, truncated;hypothetical protein 297245000587 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 297245000588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245000589 Coenzyme A binding pocket [chemical binding]; other site 297245000590 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 297245000591 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 297245000592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 297245000593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245000594 homodimer interface [polypeptide binding]; other site 297245000595 catalytic residue [active] 297245000596 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 297245000597 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 297245000598 Walker A/P-loop; other site 297245000599 ATP binding site [chemical binding]; other site 297245000600 Q-loop/lid; other site 297245000601 ABC transporter signature motif; other site 297245000602 Walker B; other site 297245000603 D-loop; other site 297245000604 H-loop/switch region; other site 297245000605 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 297245000606 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 297245000607 FtsX-like permease family; Region: FtsX; pfam02687 297245000608 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 297245000609 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245000610 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245000611 PAS domain; Region: PAS_9; pfam13426 297245000612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245000613 putative active site [active] 297245000614 heme pocket [chemical binding]; other site 297245000615 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245000616 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245000617 metal binding site [ion binding]; metal-binding site 297245000618 active site 297245000619 I-site; other site 297245000620 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245000621 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 297245000622 active site 297245000623 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 297245000624 Uncharacterized conserved protein [Function unknown]; Region: COG0432 297245000625 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 297245000626 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 297245000627 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 297245000628 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 297245000629 Protein of unknown function (DUF808); Region: DUF808; pfam05661 297245000630 RF-1 domain; Region: RF-1; pfam00472 297245000631 Protein of unknown function (DUF330); Region: DUF330; pfam03886 297245000632 mce related protein; Region: MCE; pfam02470 297245000633 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 297245000634 Permease; Region: Permease; pfam02405 297245000635 F-box-like; Region: F-box-like; cl02535 297245000636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245000637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245000638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 297245000639 dimerization interface [polypeptide binding]; other site 297245000640 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 297245000641 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 297245000642 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 297245000643 substrate binding pocket [chemical binding]; other site 297245000644 active site 297245000645 iron coordination sites [ion binding]; other site 297245000646 hypothetical protein; Provisional; Region: PRK07190 297245000647 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 297245000648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 297245000649 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 297245000650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245000651 putative substrate translocation pore; other site 297245000652 hypothetical protein; Provisional; Region: PRK07206 297245000653 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 297245000654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245000655 S-adenosylmethionine binding site [chemical binding]; other site 297245000656 similar to unknown protein from legionella, N-terminal part from aa 1-177;hypothetical protein 297245000657 similar to unknown protein from Legionella, C-terminal part 177-277;hypothetical protein 297245000658 M48 family peptidase; Provisional; Region: PRK03001 297245000659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 297245000660 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 297245000661 Similar to N-terminal part of Zn metalloprotein;hypothetical protein 297245000662 Similar to C-terminal part of Zn metalloprotein;hypothetical protein 297245000663 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 297245000664 CoA-transferase family III; Region: CoA_transf_3; pfam02515 297245000665 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 297245000666 dimer interface [polypeptide binding]; other site 297245000667 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 297245000668 active site 297245000669 heme binding site [chemical binding]; other site 297245000670 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 297245000671 Uncharacterized conserved protein [Function unknown]; Region: COG0393 297245000672 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 297245000673 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 297245000674 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 297245000675 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 297245000676 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 297245000677 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 297245000678 DAK2 domain; Region: Dak2; pfam02734 297245000679 EDD domain protein, DegV family; Region: DegV; TIGR00762 297245000680 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 297245000681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 297245000682 classical (c) SDRs; Region: SDR_c; cd05233 297245000683 NAD(P) binding site [chemical binding]; other site 297245000684 active site 297245000685 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 297245000686 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 297245000687 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 297245000688 Catalytic domain of Protein Kinases; Region: PKc; cd00180 297245000689 active site 297245000690 ATP binding site [chemical binding]; other site 297245000691 substrate binding site [chemical binding]; other site 297245000692 activation loop (A-loop); other site 297245000693 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 297245000694 TspO/MBR family; Region: TspO_MBR; pfam03073 297245000695 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 297245000696 DNA photolyase; Region: DNA_photolyase; pfam00875 297245000697 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 297245000698 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 297245000699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245000700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245000701 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 297245000702 putative dimerization interface [polypeptide binding]; other site 297245000703 Domain of unknown function (DUF329); Region: DUF329; pfam03884 297245000704 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 297245000705 ATP-grasp domain; Region: ATP-grasp; pfam02222 297245000706 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 297245000707 Nitrogen regulatory protein P-II; Region: P-II; cl00412 297245000708 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 297245000709 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 297245000710 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 297245000711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245000712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245000713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 297245000714 dimerization interface [polypeptide binding]; other site 297245000715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245000716 ATP binding site [chemical binding]; other site 297245000717 Q-loop/lid; other site 297245000718 ABC transporter signature motif; other site 297245000719 Walker B; other site 297245000720 D-loop; other site 297245000721 H-loop/switch region; other site 297245000722 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 297245000723 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245000724 Outer membrane efflux protein; Region: OEP; pfam02321 297245000725 Outer membrane efflux protein; Region: OEP; pfam02321 297245000726 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 297245000727 heme binding pocket [chemical binding]; other site 297245000728 heme ligand [chemical binding]; other site 297245000729 CHASE3 domain; Region: CHASE3; pfam05227 297245000730 PAS domain S-box; Region: sensory_box; TIGR00229 297245000731 GAF domain; Region: GAF_3; pfam13492 297245000732 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245000733 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245000734 metal binding site [ion binding]; metal-binding site 297245000735 active site 297245000736 I-site; other site 297245000737 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 297245000738 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 297245000739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245000740 motif II; other site 297245000741 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 297245000742 metal binding site 2 [ion binding]; metal-binding site 297245000743 putative DNA binding helix; other site 297245000744 metal binding site 1 [ion binding]; metal-binding site 297245000745 dimer interface [polypeptide binding]; other site 297245000746 structural Zn2+ binding site [ion binding]; other site 297245000747 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 297245000748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 297245000749 PYR/PP interface [polypeptide binding]; other site 297245000750 dimer interface [polypeptide binding]; other site 297245000751 TPP binding site [chemical binding]; other site 297245000752 Dot/Icm substrate protein; Region: SidE; pfam12252 297245000753 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 297245000754 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 297245000755 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 297245000756 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 297245000757 tetramerization interface [polypeptide binding]; other site 297245000758 NAD(P) binding site [chemical binding]; other site 297245000759 catalytic residues [active] 297245000760 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 297245000761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 297245000762 inhibitor-cofactor binding pocket; inhibition site 297245000763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245000764 catalytic residue [active] 297245000765 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 297245000766 glutaminase A; Region: Gln_ase; TIGR03814 297245000767 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 297245000768 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 297245000769 NAD binding site [chemical binding]; other site 297245000770 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 297245000771 putative NAD(P) binding site [chemical binding]; other site 297245000772 homodimer interface [polypeptide binding]; other site 297245000773 mercuric reductase; Validated; Region: PRK06370 297245000774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 297245000775 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 297245000776 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 297245000777 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 297245000778 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 297245000779 ArsC family; Region: ArsC; pfam03960 297245000780 catalytic residues [active] 297245000781 Fatty acid desaturase; Region: FA_desaturase; pfam00487 297245000782 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 297245000783 Di-iron ligands [ion binding]; other site 297245000784 Transposase; Region: DDE_Tnp_ISL3; pfam01610 297245000785 helicase 45; Provisional; Region: PTZ00424 297245000786 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 297245000787 ATP binding site [chemical binding]; other site 297245000788 Mg++ binding site [ion binding]; other site 297245000789 motif III; other site 297245000790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245000791 nucleotide binding region [chemical binding]; other site 297245000792 ATP-binding site [chemical binding]; other site 297245000793 hypothetical protein; Provisional; Region: PRK11212 297245000794 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 297245000795 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 297245000796 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 297245000797 HlyD family secretion protein; Region: HlyD; pfam00529 297245000798 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245000799 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245000800 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 297245000801 Fe-S cluster binding site [ion binding]; other site 297245000802 active site 297245000803 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 297245000804 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 297245000805 amidase catalytic site [active] 297245000806 Zn binding residues [ion binding]; other site 297245000807 substrate binding site [chemical binding]; other site 297245000808 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 297245000809 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 297245000810 Multicopper oxidase; Region: Cu-oxidase; pfam00394 297245000811 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 297245000812 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 297245000813 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 297245000814 oligomer interface [polypeptide binding]; other site 297245000815 metal binding site [ion binding]; metal-binding site 297245000816 metal binding site [ion binding]; metal-binding site 297245000817 putative Cl binding site [ion binding]; other site 297245000818 aspartate ring; other site 297245000819 hydrophobic gate; other site 297245000820 basic sphincter; other site 297245000821 periplasmic entrance; other site 297245000822 HD domain; Region: HD_3; pfam13023 297245000823 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 297245000824 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 297245000825 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 297245000826 active site 297245000827 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 297245000828 Isochorismatase family; Region: Isochorismatase; pfam00857 297245000829 catalytic triad [active] 297245000830 metal binding site [ion binding]; metal-binding site 297245000831 conserved cis-peptide bond; other site 297245000832 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 297245000833 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 297245000834 metal binding site [ion binding]; metal-binding site 297245000835 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 297245000836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245000837 putative substrate translocation pore; other site 297245000838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245000839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245000840 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 297245000841 putative effector binding pocket; other site 297245000842 dimerization interface [polypeptide binding]; other site 297245000843 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 297245000844 Ras interaction site [polypeptide binding]; other site 297245000845 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 297245000846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245000847 active site 297245000848 phosphorylation site [posttranslational modification] 297245000849 intermolecular recognition site; other site 297245000850 dimerization interface [polypeptide binding]; other site 297245000851 PAS domain; Region: PAS; smart00091 297245000852 PAS fold; Region: PAS_7; pfam12860 297245000853 putative active site [active] 297245000854 heme pocket [chemical binding]; other site 297245000855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245000856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245000857 metal binding site [ion binding]; metal-binding site 297245000858 active site 297245000859 I-site; other site 297245000860 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245000861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245000862 PAS fold; Region: PAS_3; pfam08447 297245000863 putative active site [active] 297245000864 heme pocket [chemical binding]; other site 297245000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245000866 ATP binding site [chemical binding]; other site 297245000867 Mg2+ binding site [ion binding]; other site 297245000868 G-X-G motif; other site 297245000869 FIST N domain; Region: FIST; pfam08495 297245000870 Uncharacterized conserved protein [Function unknown]; Region: COG3287 297245000871 FIST C domain; Region: FIST_C; pfam10442 297245000872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245000873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245000874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 297245000875 dimerization interface [polypeptide binding]; other site 297245000876 amino acid transporter; Region: 2A0306; TIGR00909 297245000877 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 297245000878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245000879 S-adenosylmethionine binding site [chemical binding]; other site 297245000880 formate dehydrogenase; Provisional; Region: PRK07574 297245000881 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 297245000882 dimerization interface [polypeptide binding]; other site 297245000883 ligand binding site [chemical binding]; other site 297245000884 NAD binding site [chemical binding]; other site 297245000885 catalytic site [active] 297245000886 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 297245000887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245000888 NAD(P) binding site [chemical binding]; other site 297245000889 active site 297245000890 elongation factor P; Validated; Region: PRK00529 297245000891 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 297245000892 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 297245000893 RNA binding site [nucleotide binding]; other site 297245000894 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 297245000895 RNA binding site [nucleotide binding]; other site 297245000896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 297245000897 FeS/SAM binding site; other site 297245000898 polyphosphate kinase; Provisional; Region: PRK05443 297245000899 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 297245000900 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 297245000901 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 297245000902 putative active site [active] 297245000903 catalytic site [active] 297245000904 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 297245000905 putative domain interface [polypeptide binding]; other site 297245000906 putative active site [active] 297245000907 catalytic site [active] 297245000908 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 297245000909 nucleophile elbow; other site 297245000910 Chromate transporter; Region: Chromate_transp; pfam02417 297245000911 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 297245000912 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 297245000913 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 297245000914 active site 297245000915 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 297245000916 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 297245000917 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 297245000918 Substrate binding site; other site 297245000919 metal-binding site 297245000920 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 297245000921 Phosphotransferase enzyme family; Region: APH; pfam01636 297245000922 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 297245000923 OstA-like protein; Region: OstA; cl00844 297245000924 Organic solvent tolerance protein; Region: OstA_C; pfam04453 297245000925 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 297245000926 SurA N-terminal domain; Region: SurA_N; pfam09312 297245000927 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 297245000928 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 297245000929 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 297245000930 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 297245000931 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 297245000932 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 297245000933 folate binding site [chemical binding]; other site 297245000934 NADP+ binding site [chemical binding]; other site 297245000935 Repeats found in Drosophila proteins; Region: DM9; smart00696 297245000936 Protein of unknown function (DUF3421); Region: DUF3421; pfam11901 297245000937 Repeats found in Drosophila proteins; Region: DM9; smart00696 297245000938 elongation factor Tu; Reviewed; Region: PRK00049 297245000939 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 297245000940 G1 box; other site 297245000941 GEF interaction site [polypeptide binding]; other site 297245000942 GTP/Mg2+ binding site [chemical binding]; other site 297245000943 Switch I region; other site 297245000944 G2 box; other site 297245000945 G3 box; other site 297245000946 Switch II region; other site 297245000947 G4 box; other site 297245000948 G5 box; other site 297245000949 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 297245000950 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 297245000951 Antibiotic Binding Site [chemical binding]; other site 297245000952 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 297245000953 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 297245000954 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 297245000955 putative homodimer interface [polypeptide binding]; other site 297245000956 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 297245000957 heterodimer interface [polypeptide binding]; other site 297245000958 homodimer interface [polypeptide binding]; other site 297245000959 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 297245000960 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 297245000961 23S rRNA interface [nucleotide binding]; other site 297245000962 L7/L12 interface [polypeptide binding]; other site 297245000963 putative thiostrepton binding site; other site 297245000964 L25 interface [polypeptide binding]; other site 297245000965 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 297245000966 mRNA/rRNA interface [nucleotide binding]; other site 297245000967 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 297245000968 23S rRNA interface [nucleotide binding]; other site 297245000969 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 297245000970 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 297245000971 peripheral dimer interface [polypeptide binding]; other site 297245000972 core dimer interface [polypeptide binding]; other site 297245000973 L10 interface [polypeptide binding]; other site 297245000974 L11 interface [polypeptide binding]; other site 297245000975 putative EF-Tu interaction site [polypeptide binding]; other site 297245000976 putative EF-G interaction site [polypeptide binding]; other site 297245000977 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 297245000978 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 297245000979 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 297245000980 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 297245000981 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 297245000982 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 297245000983 RPB3 interaction site [polypeptide binding]; other site 297245000984 RPB1 interaction site [polypeptide binding]; other site 297245000985 RPB11 interaction site [polypeptide binding]; other site 297245000986 RPB10 interaction site [polypeptide binding]; other site 297245000987 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 297245000988 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 297245000989 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 297245000990 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 297245000991 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 297245000992 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 297245000993 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 297245000994 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 297245000995 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 297245000996 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 297245000997 DNA binding site [nucleotide binding] 297245000998 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 297245000999 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 297245001000 S17 interaction site [polypeptide binding]; other site 297245001001 S8 interaction site; other site 297245001002 16S rRNA interaction site [nucleotide binding]; other site 297245001003 streptomycin interaction site [chemical binding]; other site 297245001004 23S rRNA interaction site [nucleotide binding]; other site 297245001005 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 297245001006 30S ribosomal protein S7; Validated; Region: PRK05302 297245001007 elongation factor G; Reviewed; Region: PRK00007 297245001008 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 297245001009 G1 box; other site 297245001010 putative GEF interaction site [polypeptide binding]; other site 297245001011 GTP/Mg2+ binding site [chemical binding]; other site 297245001012 Switch I region; other site 297245001013 G2 box; other site 297245001014 G3 box; other site 297245001015 Switch II region; other site 297245001016 G4 box; other site 297245001017 G5 box; other site 297245001018 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 297245001019 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 297245001020 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 297245001021 elongation factor Tu; Reviewed; Region: PRK00049 297245001022 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 297245001023 G1 box; other site 297245001024 GEF interaction site [polypeptide binding]; other site 297245001025 GTP/Mg2+ binding site [chemical binding]; other site 297245001026 Switch I region; other site 297245001027 G2 box; other site 297245001028 G3 box; other site 297245001029 Switch II region; other site 297245001030 G4 box; other site 297245001031 G5 box; other site 297245001032 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 297245001033 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 297245001034 Antibiotic Binding Site [chemical binding]; other site 297245001035 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 297245001036 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 297245001037 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 297245001038 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 297245001039 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 297245001040 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 297245001041 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 297245001042 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 297245001043 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 297245001044 putative translocon binding site; other site 297245001045 protein-rRNA interface [nucleotide binding]; other site 297245001046 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 297245001047 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 297245001048 G-X-X-G motif; other site 297245001049 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 297245001050 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 297245001051 23S rRNA interface [nucleotide binding]; other site 297245001052 5S rRNA interface [nucleotide binding]; other site 297245001053 putative antibiotic binding site [chemical binding]; other site 297245001054 L25 interface [polypeptide binding]; other site 297245001055 L27 interface [polypeptide binding]; other site 297245001056 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 297245001057 putative translocon interaction site; other site 297245001058 23S rRNA interface [nucleotide binding]; other site 297245001059 signal recognition particle (SRP54) interaction site; other site 297245001060 L23 interface [polypeptide binding]; other site 297245001061 trigger factor interaction site; other site 297245001062 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 297245001063 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 297245001064 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 297245001065 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 297245001066 RNA binding site [nucleotide binding]; other site 297245001067 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 297245001068 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 297245001069 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 297245001070 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK06911 297245001071 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 297245001072 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 297245001073 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 297245001074 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 297245001075 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 297245001076 23S rRNA interface [nucleotide binding]; other site 297245001077 L21e interface [polypeptide binding]; other site 297245001078 5S rRNA interface [nucleotide binding]; other site 297245001079 L27 interface [polypeptide binding]; other site 297245001080 L5 interface [polypeptide binding]; other site 297245001081 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 297245001082 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 297245001083 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 297245001084 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 297245001085 23S rRNA binding site [nucleotide binding]; other site 297245001086 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 297245001087 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 297245001088 SecY translocase; Region: SecY; pfam00344 297245001089 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 297245001090 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 297245001091 30S ribosomal protein S13; Region: bact_S13; TIGR03631 297245001092 30S ribosomal protein S11; Validated; Region: PRK05309 297245001093 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 297245001094 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 297245001095 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 297245001096 RNA binding surface [nucleotide binding]; other site 297245001097 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 297245001098 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 297245001099 alphaNTD homodimer interface [polypeptide binding]; other site 297245001100 alphaNTD - beta interaction site [polypeptide binding]; other site 297245001101 alphaNTD - beta' interaction site [polypeptide binding]; other site 297245001102 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 297245001103 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 297245001104 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 297245001105 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 297245001106 dimer interface [polypeptide binding]; other site 297245001107 ssDNA binding site [nucleotide binding]; other site 297245001108 tetramer (dimer of dimers) interface [polypeptide binding]; other site 297245001109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245001111 putative substrate translocation pore; other site 297245001112 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 297245001113 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 297245001114 putative NAD(P) binding site [chemical binding]; other site 297245001115 active site 297245001116 acyl carrier protein; Provisional; Region: acpP; PRK00982 297245001117 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 297245001118 active site 2 [active] 297245001119 active site 1 [active] 297245001120 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 297245001121 active site 2 [active] 297245001122 dimer interface [polypeptide binding]; other site 297245001123 active site 1 [active] 297245001124 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 297245001125 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 297245001126 dimer interface [polypeptide binding]; other site 297245001127 active site 297245001128 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 297245001129 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 297245001130 active site 297245001131 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 297245001132 putative acyl-acceptor binding pocket; other site 297245001133 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 297245001134 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 297245001135 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 297245001136 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 297245001137 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 297245001138 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 297245001139 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 297245001140 putative coenzyme Q binding site [chemical binding]; other site 297245001141 hypothetical protein; Validated; Region: PRK01777 297245001142 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 297245001143 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 297245001144 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 297245001145 metal binding site 2 [ion binding]; metal-binding site 297245001146 putative DNA binding helix; other site 297245001147 metal binding site 1 [ion binding]; metal-binding site 297245001148 dimer interface [polypeptide binding]; other site 297245001149 structural Zn2+ binding site [ion binding]; other site 297245001150 choline dehydrogenase; Validated; Region: PRK02106 297245001151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245001152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245001153 metal binding site [ion binding]; metal-binding site 297245001154 active site 297245001155 I-site; other site 297245001156 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 297245001157 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 297245001158 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 297245001159 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 297245001160 ATP-grasp domain; Region: ATP-grasp_4; cl17255 297245001161 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 297245001162 CoenzymeA binding site [chemical binding]; other site 297245001163 subunit interaction site [polypeptide binding]; other site 297245001164 PHB binding site; other site 297245001165 BON domain; Region: BON; pfam04972 297245001166 BON domain; Region: BON; pfam04972 297245001167 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245001168 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 297245001169 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 297245001170 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 297245001171 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 297245001172 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 297245001173 heat shock protein HtpX; Provisional; Region: PRK02870 297245001174 inner membrane transport permease; Provisional; Region: PRK15066 297245001175 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 297245001176 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 297245001177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245001178 Walker A/P-loop; other site 297245001179 ATP binding site [chemical binding]; other site 297245001180 Q-loop/lid; other site 297245001181 ABC transporter signature motif; other site 297245001182 Walker B; other site 297245001183 D-loop; other site 297245001184 H-loop/switch region; other site 297245001185 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 297245001186 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 297245001187 Protein of unknown function DUF45; Region: DUF45; pfam01863 297245001188 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 297245001189 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 297245001190 DNA binding site [nucleotide binding] 297245001191 active site 297245001192 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 297245001193 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 297245001194 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 297245001195 RimM N-terminal domain; Region: RimM; pfam01782 297245001196 PRC-barrel domain; Region: PRC; pfam05239 297245001197 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 297245001198 signal recognition particle protein; Provisional; Region: PRK10867 297245001199 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 297245001200 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 297245001201 P loop; other site 297245001202 GTP binding site [chemical binding]; other site 297245001203 Signal peptide binding domain; Region: SRP_SPB; pfam02978 297245001204 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245001205 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245001206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245001207 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 297245001208 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 297245001209 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 297245001210 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 297245001211 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 297245001212 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 297245001213 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 297245001214 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 297245001215 UbiA prenyltransferase family; Region: UbiA; pfam01040 297245001216 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 297245001217 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 297245001218 Cu(I) binding site [ion binding]; other site 297245001219 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 297245001220 RimK-like ATP-grasp domain; Region: RimK; pfam08443 297245001221 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 297245001222 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 297245001223 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 297245001224 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 297245001225 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 297245001226 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 297245001227 putative active site [active] 297245001228 phosphogluconate dehydratase; Validated; Region: PRK09054 297245001229 6-phosphogluconate dehydratase; Region: edd; TIGR01196 297245001230 Glucokinase; Region: Glucokinase; pfam02685 297245001231 glucokinase, proteobacterial type; Region: glk; TIGR00749 297245001232 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 297245001233 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 297245001234 active site 297245001235 intersubunit interface [polypeptide binding]; other site 297245001236 catalytic residue [active] 297245001237 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 297245001238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001239 putative substrate translocation pore; other site 297245001240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001241 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 297245001242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245001243 salt bridge; other site 297245001244 non-specific DNA binding site [nucleotide binding]; other site 297245001245 sequence-specific DNA binding site [nucleotide binding]; other site 297245001246 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 297245001247 ferrochelatase; Reviewed; Region: hemH; PRK00035 297245001248 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 297245001249 C-terminal domain interface [polypeptide binding]; other site 297245001250 active site 297245001251 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 297245001252 active site 297245001253 N-terminal domain interface [polypeptide binding]; other site 297245001254 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 297245001255 DNA-binding site [nucleotide binding]; DNA binding site 297245001256 RNA-binding motif; other site 297245001257 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 297245001258 HIT family signature motif; other site 297245001259 catalytic residue [active] 297245001260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 297245001261 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 297245001262 active site 297245001263 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 297245001264 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 297245001265 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245001266 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245001267 Predicted membrane protein [Function unknown]; Region: COG1289 297245001268 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 297245001269 Predicted transcriptional regulators [Transcription]; Region: COG1733 297245001270 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 297245001271 Uncharacterized conserved protein [Function unknown]; Region: COG4278 297245001272 Methyltransferase domain; Region: Methyltransf_23; pfam13489 297245001273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245001274 S-adenosylmethionine binding site [chemical binding]; other site 297245001275 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245001276 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245001277 Protein of unknown function (DUF3773); Region: DUF3773; pfam12608 297245001278 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; pfam09475 297245001279 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 297245001280 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 297245001281 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245001282 ligand binding site [chemical binding]; other site 297245001283 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245001284 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 297245001285 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 297245001286 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 297245001287 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 297245001288 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 297245001289 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 297245001290 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 297245001291 HNH nucleases; Region: HNHc; smart00507 297245001292 AAA-like domain; Region: AAA_10; pfam12846 297245001293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001294 metabolite-proton symporter; Region: 2A0106; TIGR00883 297245001295 putative substrate translocation pore; other site 297245001296 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 297245001297 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 297245001298 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 297245001299 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 297245001300 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 297245001301 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 297245001302 purine monophosphate binding site [chemical binding]; other site 297245001303 dimer interface [polypeptide binding]; other site 297245001304 putative catalytic residues [active] 297245001305 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 297245001306 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 297245001307 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 297245001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245001309 S-adenosylmethionine binding site [chemical binding]; other site 297245001310 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 297245001311 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 297245001312 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 297245001313 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 297245001314 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 297245001315 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 297245001316 carboxyltransferase (CT) interaction site; other site 297245001317 biotinylation site [posttranslational modification]; other site 297245001318 Dehydroquinase class II; Region: DHquinase_II; pfam01220 297245001319 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 297245001320 trimer interface [polypeptide binding]; other site 297245001321 active site 297245001322 dimer interface [polypeptide binding]; other site 297245001323 pyruvate carboxylase subunit B; Provisional; Region: PRK14042 297245001324 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 297245001325 active site 297245001326 catalytic residues [active] 297245001327 metal binding site [ion binding]; metal-binding site 297245001328 homodimer binding site [polypeptide binding]; other site 297245001329 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 297245001330 carboxyltransferase (CT) interaction site; other site 297245001331 biotinylation site [posttranslational modification]; other site 297245001332 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 297245001333 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 297245001334 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 297245001335 active site 297245001336 Zn binding site [ion binding]; other site 297245001337 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245001338 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 297245001339 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 297245001340 putative catalytic site [active] 297245001341 putative metal binding site [ion binding]; other site 297245001342 putative phosphate binding site [ion binding]; other site 297245001343 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 297245001344 active site 297245001345 intersubunit interface [polypeptide binding]; other site 297245001346 catalytic residue [active] 297245001347 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 297245001348 ferredoxin-NADP reductase; Provisional; Region: PRK10926 297245001349 FAD binding pocket [chemical binding]; other site 297245001350 FAD binding motif [chemical binding]; other site 297245001351 phosphate binding motif [ion binding]; other site 297245001352 beta-alpha-beta structure motif; other site 297245001353 NAD binding pocket [chemical binding]; other site 297245001354 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 297245001355 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 297245001356 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 297245001357 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 297245001358 dimerization domain swap beta strand [polypeptide binding]; other site 297245001359 regulatory protein interface [polypeptide binding]; other site 297245001360 active site 297245001361 regulatory phosphorylation site [posttranslational modification]; other site 297245001362 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 297245001363 30S subunit binding site; other site 297245001364 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 297245001365 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 297245001366 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 297245001367 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 297245001368 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 297245001369 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 297245001370 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 297245001371 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 297245001372 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 297245001373 oligomer interface [polypeptide binding]; other site 297245001374 active site 297245001375 metal binding site [ion binding]; metal-binding site 297245001376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245001377 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245001378 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245001379 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 297245001380 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 297245001381 HflK protein; Region: hflK; TIGR01933 297245001382 FtsH protease regulator HflC; Provisional; Region: PRK11029 297245001383 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 297245001384 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 297245001385 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 297245001386 GDP-binding site [chemical binding]; other site 297245001387 ACT binding site; other site 297245001388 IMP binding site; other site 297245001389 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 297245001390 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 297245001391 Arginine repressor [Transcription]; Region: ArgR; COG1438 297245001392 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 297245001393 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245001394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245001395 substrate binding pocket [chemical binding]; other site 297245001396 membrane-bound complex binding site; other site 297245001397 hinge residues; other site 297245001398 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 297245001399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245001400 dimer interface [polypeptide binding]; other site 297245001401 conserved gate region; other site 297245001402 putative PBP binding loops; other site 297245001403 ABC-ATPase subunit interface; other site 297245001404 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 297245001405 ATP-binding cassette domain of the binding protein-dependent transport systems; Region: ABC_Class3; cd03229 297245001406 Walker A/P-loop; other site 297245001407 ATP binding site [chemical binding]; other site 297245001408 Q-loop/lid; other site 297245001409 ABC transporter signature motif; other site 297245001410 Walker B; other site 297245001411 D-loop; other site 297245001412 H-loop/switch region; other site 297245001413 argininosuccinate synthase; Provisional; Region: PRK13820 297245001414 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 297245001415 ANP binding site [chemical binding]; other site 297245001416 Substrate Binding Site II [chemical binding]; other site 297245001417 Substrate Binding Site I [chemical binding]; other site 297245001418 Lyase; Region: Lyase_1; pfam00206 297245001419 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 297245001420 active sites [active] 297245001421 tetramer interface [polypeptide binding]; other site 297245001422 ornithine carbamoyltransferase; Provisional; Region: PRK00779 297245001423 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 297245001424 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 297245001425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 297245001426 active site 297245001427 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 297245001428 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 297245001429 putative ligand binding site [chemical binding]; other site 297245001430 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 297245001431 C-terminal peptidase (prc); Region: prc; TIGR00225 297245001432 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 297245001433 protein binding site [polypeptide binding]; other site 297245001434 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 297245001435 Catalytic dyad [active] 297245001436 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 297245001437 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 297245001438 Peptidase family M23; Region: Peptidase_M23; pfam01551 297245001439 phosphoglyceromutase; Provisional; Region: PRK05434 297245001440 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 297245001441 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 297245001442 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 297245001443 catalytic residue [active] 297245001444 putative FPP diphosphate binding site; other site 297245001445 putative FPP binding hydrophobic cleft; other site 297245001446 dimer interface [polypeptide binding]; other site 297245001447 putative IPP diphosphate binding site; other site 297245001448 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 297245001449 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 297245001450 zinc metallopeptidase RseP; Provisional; Region: PRK10779 297245001451 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 297245001452 active site 297245001453 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 297245001454 protein binding site [polypeptide binding]; other site 297245001455 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 297245001456 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 297245001457 putative substrate binding region [chemical binding]; other site 297245001458 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 297245001459 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 297245001460 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 297245001461 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 297245001462 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 297245001463 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 297245001464 Surface antigen; Region: Bac_surface_Ag; pfam01103 297245001465 periplasmic chaperone; Provisional; Region: PRK10780 297245001466 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 297245001467 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 297245001468 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 297245001469 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 297245001470 trimer interface [polypeptide binding]; other site 297245001471 active site 297245001472 UDP-GlcNAc binding site [chemical binding]; other site 297245001473 lipid binding site [chemical binding]; lipid-binding site 297245001474 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 297245001475 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 297245001476 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 297245001477 active site 297245001478 camphor resistance protein CrcB; Provisional; Region: PRK14217 297245001479 seryl-tRNA synthetase; Provisional; Region: PRK05431 297245001480 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 297245001481 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 297245001482 dimer interface [polypeptide binding]; other site 297245001483 active site 297245001484 motif 1; other site 297245001485 motif 2; other site 297245001486 motif 3; other site 297245001487 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 297245001488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 297245001489 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 297245001490 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 297245001491 Methyltransferase domain; Region: Methyltransf_12; pfam08242 297245001492 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 297245001493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 297245001494 active site 297245001495 catalytic tetrad [active] 297245001496 hypothetical protein 297245001497 Methyltransferase domain; Region: Methyltransf_23; pfam13489 297245001498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245001499 S-adenosylmethionine binding site [chemical binding]; other site 297245001500 hypothetical protein; Provisional; Region: PRK08233 297245001501 AAA domain; Region: AAA_18; pfam13238 297245001502 active site 297245001503 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 297245001504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245001505 Coenzyme A binding pocket [chemical binding]; other site 297245001506 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 297245001507 putative active site [active] 297245001508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245001509 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 297245001510 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 297245001511 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 297245001512 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 297245001513 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 297245001514 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 297245001515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245001516 motif II; other site 297245001517 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 297245001518 Universal stress protein family; Region: Usp; pfam00582 297245001519 universal stress protein UspE; Provisional; Region: PRK11175 297245001520 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 297245001521 Ligand Binding Site [chemical binding]; other site 297245001522 putative cation:proton antiport protein; Provisional; Region: PRK10669 297245001523 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 297245001524 TrkA-N domain; Region: TrkA_N; pfam02254 297245001525 Similar to C-terminal part of universal stress protein UspA;hypothetical protein 297245001526 Similar to N-terminal part of universal stress protein UspA;hypothetical protein 297245001527 Transposase; Region: HTH_Tnp_1; pfam01527 297245001528 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 297245001529 putative transposase OrfB; Reviewed; Region: PHA02517 297245001530 HTH-like domain; Region: HTH_21; pfam13276 297245001531 Integrase core domain; Region: rve; pfam00665 297245001532 Integrase core domain; Region: rve_3; pfam13683 297245001533 RDD family; Region: RDD; pfam06271 297245001534 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 297245001535 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 297245001536 Iron-sulfur protein interface; other site 297245001537 proximal quinone binding site [chemical binding]; other site 297245001538 SdhD (CybS) interface [polypeptide binding]; other site 297245001539 proximal heme binding site [chemical binding]; other site 297245001540 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 297245001541 SdhC subunit interface [polypeptide binding]; other site 297245001542 proximal heme binding site [chemical binding]; other site 297245001543 cardiolipin binding site; other site 297245001544 Iron-sulfur protein interface; other site 297245001545 proximal quinone binding site [chemical binding]; other site 297245001546 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 297245001547 L-aspartate oxidase; Provisional; Region: PRK06175 297245001548 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 297245001549 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 297245001550 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 297245001551 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 297245001552 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 297245001553 TPP-binding site [chemical binding]; other site 297245001554 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 297245001555 dimer interface [polypeptide binding]; other site 297245001556 PYR/PP interface [polypeptide binding]; other site 297245001557 TPP binding site [chemical binding]; other site 297245001558 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 297245001559 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 297245001560 E3 interaction surface; other site 297245001561 lipoyl attachment site [posttranslational modification]; other site 297245001562 e3 binding domain; Region: E3_binding; pfam02817 297245001563 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 297245001564 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 297245001565 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 297245001566 CoA-ligase; Region: Ligase_CoA; pfam00549 297245001567 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 297245001568 CoA binding domain; Region: CoA_binding; smart00881 297245001569 CoA-ligase; Region: Ligase_CoA; pfam00549 297245001570 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 297245001571 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 297245001572 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 297245001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001574 D-galactonate transporter; Region: 2A0114; TIGR00893 297245001575 putative substrate translocation pore; other site 297245001576 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 297245001577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 297245001578 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 297245001579 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 297245001580 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 297245001581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245001582 active site 297245001583 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 297245001584 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 297245001585 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 297245001586 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 297245001587 active site 297245001588 (T/H)XGH motif; other site 297245001589 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 297245001590 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 297245001591 weakly similar to D-amino acid dehydrogenase, C-terminal cAMP binding motif;hypothetical protein 297245001592 weakly similar to D-amino acid dehydrogenase, truncated;hypothetical protein 297245001593 weakly similar to D-amino acid dehydrogenase, truncated;hypothetical protein 297245001594 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 297245001595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 297245001596 putative acyl-acceptor binding pocket; other site 297245001597 multidrug efflux system protein; Provisional; Region: PRK11431 297245001598 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 297245001599 Phosphotransferase enzyme family; Region: APH; pfam01636 297245001600 putative active site [active] 297245001601 putative substrate binding site [chemical binding]; other site 297245001602 ATP binding site [chemical binding]; other site 297245001603 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 297245001604 active site 297245001605 DNA polymerase IV; Validated; Region: PRK02406 297245001606 DNA binding site [nucleotide binding] 297245001607 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 297245001608 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 297245001609 DNA binding site [nucleotide binding] 297245001610 catalytic residue [active] 297245001611 H2TH interface [polypeptide binding]; other site 297245001612 putative catalytic residues [active] 297245001613 turnover-facilitating residue; other site 297245001614 intercalation triad [nucleotide binding]; other site 297245001615 8OG recognition residue [nucleotide binding]; other site 297245001616 putative reading head residues; other site 297245001617 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 297245001618 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 297245001619 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 297245001620 Fatty acid desaturase; Region: FA_desaturase; pfam00487 297245001621 Di-iron ligands [ion binding]; other site 297245001622 Transposase; Region: DDE_Tnp_ISL3; pfam01610 297245001623 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 297245001624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245001625 NAD(P) binding site [chemical binding]; other site 297245001626 active site 297245001627 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 297245001628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245001629 NAD(P) binding site [chemical binding]; other site 297245001630 active site 297245001631 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 297245001632 Phasin protein; Region: Phasin_2; cl11491 297245001633 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 297245001634 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 297245001635 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 297245001636 putative peptidase; Provisional; Region: PRK11649 297245001637 Peptidase family M23; Region: Peptidase_M23; pfam01551 297245001638 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 297245001639 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 297245001640 active site 297245001641 HIGH motif; other site 297245001642 dimer interface [polypeptide binding]; other site 297245001643 KMSKS motif; other site 297245001644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 297245001645 RNA binding surface [nucleotide binding]; other site 297245001646 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 297245001647 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 297245001648 hinge; other site 297245001649 active site 297245001650 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 297245001651 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 297245001652 trimer interface [polypeptide binding]; other site 297245001653 putative metal binding site [ion binding]; other site 297245001654 glutathione reductase; Validated; Region: PRK06116 297245001655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 297245001656 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 297245001657 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 297245001658 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 297245001659 adenosine deaminase; Provisional; Region: PRK09358 297245001660 active site 297245001661 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 297245001662 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 297245001663 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 297245001664 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 297245001665 hypothetical protein; Validated; Region: PRK00228 297245001666 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 297245001667 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 297245001668 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 297245001669 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 297245001670 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 297245001671 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 297245001672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245001673 Walker A motif; other site 297245001674 ATP binding site [chemical binding]; other site 297245001675 Walker B motif; other site 297245001676 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 297245001677 Membrane fusogenic activity; Region: BMFP; pfam04380 297245001678 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 297245001679 Nitrogen regulatory protein P-II; Region: P-II; smart00938 297245001680 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 297245001681 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 297245001682 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 297245001683 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 297245001684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245001685 catalytic residue [active] 297245001686 Uncharacterized conserved protein [Function unknown]; Region: COG0398 297245001687 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 297245001688 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 297245001689 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 297245001690 putative acyl-acceptor binding pocket; other site 297245001691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 297245001692 acyl-activating enzyme (AAE) consensus motif; other site 297245001693 AMP binding site [chemical binding]; other site 297245001694 active site 297245001695 CoA binding site [chemical binding]; other site 297245001696 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 297245001697 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 297245001698 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 297245001699 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 297245001700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 297245001701 putative DNA binding site [nucleotide binding]; other site 297245001702 putative Zn2+ binding site [ion binding]; other site 297245001703 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 297245001704 putative ABC transporter; Region: ycf24; CHL00085 297245001705 FeS assembly ATPase SufC; Region: sufC; TIGR01978 297245001706 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 297245001707 Walker A/P-loop; other site 297245001708 ATP binding site [chemical binding]; other site 297245001709 Q-loop/lid; other site 297245001710 ABC transporter signature motif; other site 297245001711 Walker B; other site 297245001712 D-loop; other site 297245001713 H-loop/switch region; other site 297245001714 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 297245001715 FeS assembly protein SufD; Region: sufD; TIGR01981 297245001716 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 297245001717 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 297245001718 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 297245001719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245001720 catalytic residue [active] 297245001721 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 297245001722 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 297245001723 trimerization site [polypeptide binding]; other site 297245001724 active site 297245001725 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 297245001726 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 297245001727 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 297245001728 motif 1; other site 297245001729 dimer interface [polypeptide binding]; other site 297245001730 active site 297245001731 motif 2; other site 297245001732 motif 3; other site 297245001733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245001734 S-adenosylmethionine binding site [chemical binding]; other site 297245001735 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 297245001736 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 297245001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001738 putative substrate translocation pore; other site 297245001739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245001740 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 297245001741 Domain of unknown function DUF21; Region: DUF21; pfam01595 297245001742 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 297245001743 Transporter associated domain; Region: CorC_HlyC; smart01091 297245001744 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 297245001745 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 297245001746 putative NAD(P) binding site [chemical binding]; other site 297245001747 putative substrate binding site [chemical binding]; other site 297245001748 catalytic Zn binding site [ion binding]; other site 297245001749 structural Zn binding site [ion binding]; other site 297245001750 dimer interface [polypeptide binding]; other site 297245001751 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 297245001752 Similar to C-terminal part of polypeptide deformylase;hypothetical protein 297245001753 Similar to N-terminal part of polypeptide deformylase;hypothetical protein 297245001754 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 297245001755 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 297245001756 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 297245001757 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 297245001758 CoA binding domain; Region: CoA_binding_2; pfam13380 297245001759 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 297245001760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 297245001761 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 297245001762 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245001763 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 297245001764 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 297245001765 Cupin domain; Region: Cupin_2; cl17218 297245001766 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 297245001767 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 297245001768 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 297245001769 Competence protein; Region: Competence; pfam03772 297245001770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 297245001771 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 297245001772 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 297245001773 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 297245001774 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 297245001775 PilX N-terminal; Region: PilX_N; pfam14341 297245001776 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 297245001777 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 297245001778 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 297245001779 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 297245001780 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 297245001781 Type II transport protein GspH; Region: GspH; pfam12019 297245001782 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 297245001783 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 297245001784 NodB motif; other site 297245001785 putative active site [active] 297245001786 putative catalytic site [active] 297245001787 putative Zn binding site [ion binding]; other site 297245001788 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 297245001789 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 297245001790 thymidine kinase; Provisional; Region: PRK04296 297245001791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245001793 putative substrate translocation pore; other site 297245001794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001795 putative substrate translocation pore; other site 297245001796 D-galactonate transporter; Region: 2A0114; TIGR00893 297245001797 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 297245001798 phosphopentomutase; Provisional; Region: PRK05362 297245001799 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 297245001800 active site 297245001801 HslU subunit interaction site [polypeptide binding]; other site 297245001802 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 297245001803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245001804 Walker A motif; other site 297245001805 ATP binding site [chemical binding]; other site 297245001806 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 297245001807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 297245001808 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 297245001809 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001810 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001811 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001812 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001813 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001814 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001815 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001816 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001817 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 297245001818 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 297245001819 metal ion-dependent adhesion site (MIDAS); other site 297245001820 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 297245001821 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 297245001822 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 297245001823 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 297245001824 putative active site [active] 297245001825 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 297245001826 putative active site [active] 297245001827 putative catalytic site [active] 297245001828 putative DNA binding site [nucleotide binding]; other site 297245001829 putative phosphate binding site [ion binding]; other site 297245001830 metal binding site A [ion binding]; metal-binding site 297245001831 putative AP binding site [nucleotide binding]; other site 297245001832 putative metal binding site B [ion binding]; other site 297245001833 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 297245001834 putative catalytic site [active] 297245001835 putative phosphate binding site [ion binding]; other site 297245001836 active site 297245001837 metal binding site A [ion binding]; metal-binding site 297245001838 DNA binding site [nucleotide binding] 297245001839 putative AP binding site [nucleotide binding]; other site 297245001840 putative metal binding site B [ion binding]; other site 297245001841 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 297245001842 Malic enzyme, N-terminal domain; Region: malic; pfam00390 297245001843 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 297245001844 putative NAD(P) binding site [chemical binding]; other site 297245001845 D-galactonate transporter; Region: 2A0114; TIGR00893 297245001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001847 putative substrate translocation pore; other site 297245001848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245001849 putative substrate translocation pore; other site 297245001850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245001851 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 297245001852 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 297245001853 aromatic amino acid transport protein; Region: araaP; TIGR00837 297245001854 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 297245001855 aromatic amino acid transport protein; Region: araaP; TIGR00837 297245001856 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 297245001857 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245001858 ligand binding site [chemical binding]; other site 297245001859 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 297245001860 putative active site [active] 297245001861 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 297245001862 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245001863 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 297245001864 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245001865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 297245001866 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 297245001867 Walker A/P-loop; other site 297245001868 ATP binding site [chemical binding]; other site 297245001869 Q-loop/lid; other site 297245001870 ABC transporter signature motif; other site 297245001871 Walker B; other site 297245001872 D-loop; other site 297245001873 H-loop/switch region; other site 297245001874 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 297245001875 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 297245001876 Walker A/P-loop; other site 297245001877 ATP binding site [chemical binding]; other site 297245001878 Q-loop/lid; other site 297245001879 ABC transporter signature motif; other site 297245001880 Walker B; other site 297245001881 D-loop; other site 297245001882 H-loop/switch region; other site 297245001883 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 297245001884 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 297245001885 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 297245001886 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 297245001887 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 297245001888 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 297245001889 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 297245001890 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 297245001891 N-acetyl-D-glucosamine binding site [chemical binding]; other site 297245001892 catalytic residue [active] 297245001893 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 297245001894 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 297245001895 substrate binding site [chemical binding]; other site 297245001896 hexamer interface [polypeptide binding]; other site 297245001897 metal binding site [ion binding]; metal-binding site 297245001898 DoxX; Region: DoxX; pfam07681 297245001899 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 297245001900 hypothetical protein; Provisional; Region: PRK05409 297245001901 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 297245001902 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 297245001903 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 297245001904 nucleophile elbow; other site 297245001905 Predicted membrane protein [Function unknown]; Region: COG2259 297245001906 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 297245001907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 297245001908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 297245001909 acetoacetate decarboxylase; Provisional; Region: PRK02265 297245001910 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 297245001911 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 297245001912 cyclase homology domain; Region: CHD; cd07302 297245001913 nucleotidyl binding site; other site 297245001914 metal binding site [ion binding]; metal-binding site 297245001915 dimer interface [polypeptide binding]; other site 297245001916 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 297245001917 hypothetical protein; Provisional; Region: PRK05409 297245001918 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245001919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245001920 substrate binding pocket [chemical binding]; other site 297245001921 membrane-bound complex binding site; other site 297245001922 hinge residues; other site 297245001923 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 297245001924 metal binding triad; other site 297245001925 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 297245001926 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 297245001927 metal binding triad; other site 297245001928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245001929 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 297245001930 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 297245001931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 297245001932 Walker A/P-loop; other site 297245001933 ATP binding site [chemical binding]; other site 297245001934 Q-loop/lid; other site 297245001935 ABC transporter signature motif; other site 297245001936 Walker B; other site 297245001937 D-loop; other site 297245001938 H-loop/switch region; other site 297245001939 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 297245001940 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 297245001941 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 297245001942 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 297245001943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245001944 FeS/SAM binding site; other site 297245001945 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 297245001946 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 297245001947 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 297245001948 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 297245001949 DsbD alpha interface [polypeptide binding]; other site 297245001950 catalytic residues [active] 297245001951 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 297245001952 oligomerisation interface [polypeptide binding]; other site 297245001953 mobile loop; other site 297245001954 roof hairpin; other site 297245001955 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 297245001956 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 297245001957 ring oligomerisation interface [polypeptide binding]; other site 297245001958 ATP/Mg binding site [chemical binding]; other site 297245001959 stacking interactions; other site 297245001960 hinge regions; other site 297245001961 Ferritin-like domain; Region: Ferritin; pfam00210 297245001962 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 297245001963 dimerization interface [polypeptide binding]; other site 297245001964 DPS ferroxidase diiron center [ion binding]; other site 297245001965 ion pore; other site 297245001966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245001967 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 297245001968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245001969 Mg2+ binding site [ion binding]; other site 297245001970 G-X-G motif; other site 297245001971 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 297245001972 anchoring element; other site 297245001973 dimer interface [polypeptide binding]; other site 297245001974 ATP binding site [chemical binding]; other site 297245001975 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 297245001976 active site 297245001977 metal binding site [ion binding]; metal-binding site 297245001978 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 297245001979 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 297245001980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 297245001981 Walker A/P-loop; other site 297245001982 ATP binding site [chemical binding]; other site 297245001983 Q-loop/lid; other site 297245001984 ABC transporter signature motif; other site 297245001985 Walker B; other site 297245001986 D-loop; other site 297245001987 H-loop/switch region; other site 297245001988 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 297245001989 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 297245001990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 297245001991 Walker A/P-loop; other site 297245001992 ATP binding site [chemical binding]; other site 297245001993 Q-loop/lid; other site 297245001994 ABC transporter signature motif; other site 297245001995 Walker B; other site 297245001996 D-loop; other site 297245001997 H-loop/switch region; other site 297245001998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 297245001999 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 297245002000 prolyl-tRNA synthetase; Provisional; Region: PRK09194 297245002001 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 297245002002 dimer interface [polypeptide binding]; other site 297245002003 motif 1; other site 297245002004 active site 297245002005 motif 2; other site 297245002006 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 297245002007 putative deacylase active site [active] 297245002008 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 297245002009 active site 297245002010 motif 3; other site 297245002011 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 297245002012 anticodon binding site; other site 297245002013 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 297245002014 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245002015 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245002016 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245002017 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245002018 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245002019 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 297245002020 Sulfate transporter family; Region: Sulfate_transp; pfam00916 297245002021 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 297245002022 active site clefts [active] 297245002023 zinc binding site [ion binding]; other site 297245002024 dimer interface [polypeptide binding]; other site 297245002025 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 297245002026 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 297245002027 Ligand Binding Site [chemical binding]; other site 297245002028 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 297245002029 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 297245002030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245002031 S-adenosylmethionine binding site [chemical binding]; other site 297245002032 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 297245002033 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 297245002034 substrate-cofactor binding pocket; other site 297245002035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245002036 catalytic residue [active] 297245002037 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 297245002038 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 297245002039 NAD(P) binding site [chemical binding]; other site 297245002040 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 297245002041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245002042 Walker A/P-loop; other site 297245002043 ATP binding site [chemical binding]; other site 297245002044 Q-loop/lid; other site 297245002045 ABC transporter signature motif; other site 297245002046 Walker B; other site 297245002047 D-loop; other site 297245002048 H-loop/switch region; other site 297245002049 ABC transporter; Region: ABC_tran_2; pfam12848 297245002050 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245002051 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245002052 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 297245002053 Predicted transporter component [General function prediction only]; Region: COG2391 297245002054 Sulphur transport; Region: Sulf_transp; pfam04143 297245002055 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 297245002056 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245002057 formimidoylglutamase; Provisional; Region: PRK13775 297245002058 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 297245002059 putative active site [active] 297245002060 putative metal binding site [ion binding]; other site 297245002061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245002062 short chain dehydrogenase; Provisional; Region: PRK06924 297245002063 NAD(P) binding site [chemical binding]; other site 297245002064 active site 297245002065 imidazolonepropionase; Validated; Region: PRK09356 297245002066 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 297245002067 active site 297245002068 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 297245002069 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 297245002070 Predicted membrane protein [Function unknown]; Region: COG1297 297245002071 putative oligopeptide transporter, OPT family; Region: TIGR00733 297245002072 HAMP domain; Region: HAMP; pfam00672 297245002073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245002074 dimer interface [polypeptide binding]; other site 297245002075 phosphorylation site [posttranslational modification] 297245002076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245002077 ATP binding site [chemical binding]; other site 297245002078 Mg2+ binding site [ion binding]; other site 297245002079 G-X-G motif; other site 297245002080 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 297245002081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245002082 active site 297245002083 phosphorylation site [posttranslational modification] 297245002084 intermolecular recognition site; other site 297245002085 dimerization interface [polypeptide binding]; other site 297245002086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 297245002087 DNA binding site [nucleotide binding] 297245002088 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 297245002089 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 297245002090 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 297245002091 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 297245002092 HIGH motif; other site 297245002093 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 297245002094 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 297245002095 active site 297245002096 KMSKS motif; other site 297245002097 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 297245002098 tRNA binding surface [nucleotide binding]; other site 297245002099 anticodon binding site; other site 297245002100 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 297245002101 multidrug efflux protein; Reviewed; Region: PRK09579 297245002102 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 297245002103 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 297245002104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245002105 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245002106 BON domain; Region: BON; pfam04972 297245002107 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 297245002108 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 297245002109 dimer interface [polypeptide binding]; other site 297245002110 active site 297245002111 glycine-pyridoxal phosphate binding site [chemical binding]; other site 297245002112 folate binding site [chemical binding]; other site 297245002113 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 297245002114 ATP cone domain; Region: ATP-cone; pfam03477 297245002115 transcription antitermination factor NusB; Region: nusB; TIGR01951 297245002116 putative RNA binding site [nucleotide binding]; other site 297245002117 thiamine monophosphate kinase; Provisional; Region: PRK05731 297245002118 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 297245002119 ATP binding site [chemical binding]; other site 297245002120 dimerization interface [polypeptide binding]; other site 297245002121 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 297245002122 tetramer interfaces [polypeptide binding]; other site 297245002123 binuclear metal-binding site [ion binding]; other site 297245002124 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 297245002125 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 297245002126 NAD synthetase; Provisional; Region: PRK13981 297245002127 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 297245002128 multimer interface [polypeptide binding]; other site 297245002129 active site 297245002130 catalytic triad [active] 297245002131 protein interface 1 [polypeptide binding]; other site 297245002132 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 297245002133 homodimer interface [polypeptide binding]; other site 297245002134 NAD binding pocket [chemical binding]; other site 297245002135 ATP binding pocket [chemical binding]; other site 297245002136 Mg binding site [ion binding]; other site 297245002137 active-site loop [active] 297245002138 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 297245002139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245002140 ATP binding site [chemical binding]; other site 297245002141 putative Mg++ binding site [ion binding]; other site 297245002142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245002143 nucleotide binding region [chemical binding]; other site 297245002144 ATP-binding site [chemical binding]; other site 297245002145 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 297245002146 replicative DNA helicase; Region: DnaB; TIGR00665 297245002147 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 297245002148 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 297245002149 Walker A motif; other site 297245002150 ATP binding site [chemical binding]; other site 297245002151 Walker B motif; other site 297245002152 DNA binding loops [nucleotide binding] 297245002153 alanine racemase; Reviewed; Region: alr; PRK00053 297245002154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 297245002155 active site 297245002156 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 297245002157 substrate binding site [chemical binding]; other site 297245002158 catalytic residues [active] 297245002159 dimer interface [polypeptide binding]; other site 297245002160 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 297245002161 FOG: CBS domain [General function prediction only]; Region: COG0517 297245002162 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 297245002163 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 297245002164 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 297245002165 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 297245002166 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245002167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245002168 metal binding site [ion binding]; metal-binding site 297245002169 active site 297245002170 I-site; other site 297245002171 lipoyl synthase; Provisional; Region: PRK05481 297245002172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245002173 FeS/SAM binding site; other site 297245002174 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 297245002175 GIY-YIG motif/motif A; other site 297245002176 putative active site [active] 297245002177 putative metal binding site [ion binding]; other site 297245002178 POT family; Region: PTR2; cl17359 297245002179 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 297245002180 Methyltransferase domain; Region: Methyltransf_11; pfam08241 297245002181 S-adenosylmethionine binding site [chemical binding]; other site 297245002182 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 297245002183 Ligand Binding Site [chemical binding]; other site 297245002184 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 297245002185 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 297245002186 substrate binding site [chemical binding]; other site 297245002187 glutamase interaction surface [polypeptide binding]; other site 297245002188 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 297245002189 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 297245002190 putative active site [active] 297245002191 oxyanion strand; other site 297245002192 catalytic triad [active] 297245002193 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 297245002194 ligand binding site; other site 297245002195 tetramer interface; other site 297245002196 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 297245002197 NeuB family; Region: NeuB; pfam03102 297245002198 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 297245002199 NeuB binding interface [polypeptide binding]; other site 297245002200 putative substrate binding site [chemical binding]; other site 297245002201 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 297245002202 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 297245002203 active site 297245002204 homodimer interface [polypeptide binding]; other site 297245002205 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 297245002206 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 297245002207 putative trimer interface [polypeptide binding]; other site 297245002208 putative CoA binding site [chemical binding]; other site 297245002209 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 297245002210 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 297245002211 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 297245002212 inhibitor-cofactor binding pocket; inhibition site 297245002213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245002214 catalytic residue [active] 297245002215 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 297245002216 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 297245002217 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 297245002218 NADP binding site [chemical binding]; other site 297245002219 active site 297245002220 putative substrate binding site [chemical binding]; other site 297245002221 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 297245002222 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 297245002223 NAD binding site [chemical binding]; other site 297245002224 substrate binding site [chemical binding]; other site 297245002225 homodimer interface [polypeptide binding]; other site 297245002226 active site 297245002227 Phosphoglucose isomerase; Region: PGI; pfam00342 297245002228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245002229 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 297245002230 active site 297245002231 dimer interface [polypeptide binding]; other site 297245002232 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 297245002233 dimer interface [polypeptide binding]; other site 297245002234 active site 297245002235 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 297245002236 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 297245002237 substrate binding site; other site 297245002238 tetramer interface; other site 297245002239 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 297245002240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245002241 NAD(P) binding site [chemical binding]; other site 297245002242 active site 297245002243 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 297245002244 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 297245002245 Mg++ binding site [ion binding]; other site 297245002246 putative catalytic motif [active] 297245002247 putative substrate binding site [chemical binding]; other site 297245002248 putative transposase OrfB; Reviewed; Region: PHA02517 297245002249 HTH-like domain; Region: HTH_21; pfam13276 297245002250 Integrase core domain; Region: rve; pfam00665 297245002251 Integrase core domain; Region: rve_3; pfam13683 297245002252 Homeodomain-like domain; Region: HTH_23; pfam13384 297245002253 Winged helix-turn helix; Region: HTH_29; pfam13551 297245002254 Winged helix-turn helix; Region: HTH_33; pfam13592 297245002255 DDE superfamily endonuclease; Region: DDE_3; pfam13358 297245002256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 297245002257 Similar to transposase, truncated;hypothetical protein 297245002258 Right handed beta helix region; Region: Beta_helix; pfam13229 297245002259 Radical SAM superfamily; Region: Radical_SAM; pfam04055 297245002260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245002261 FeS/SAM binding site; other site 297245002262 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 297245002263 Similar to transposase, truncated;hypothetical protein 297245002264 Similar to transposase, truncated;hypothetical protein 297245002265 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 297245002266 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 297245002267 substrate binding site [chemical binding]; other site 297245002268 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 297245002269 NeuB family; Region: NeuB; pfam03102 297245002270 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 297245002271 NeuB binding interface [polypeptide binding]; other site 297245002272 putative substrate binding site [chemical binding]; other site 297245002273 Methyltransferase domain; Region: Methyltransf_31; pfam13847 297245002274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245002275 S-adenosylmethionine binding site [chemical binding]; other site 297245002276 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 297245002277 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 297245002278 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 297245002279 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 297245002280 Walker A/P-loop; other site 297245002281 ATP binding site [chemical binding]; other site 297245002282 Q-loop/lid; other site 297245002283 ABC transporter signature motif; other site 297245002284 Walker B; other site 297245002285 D-loop; other site 297245002286 H-loop/switch region; other site 297245002287 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 297245002288 putative carbohydrate binding site [chemical binding]; other site 297245002289 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 297245002290 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 297245002291 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 297245002292 Probable Catalytic site; other site 297245002293 metal-binding site 297245002294 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 297245002295 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 297245002296 Probable Catalytic site; other site 297245002297 metal-binding site 297245002298 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 297245002299 carbon storage regulator; Provisional; Region: PRK01712 297245002300 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 297245002301 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 297245002302 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 297245002303 Biotin operon repressor [Transcription]; Region: BirA; COG1654 297245002304 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 297245002305 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 297245002306 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 297245002307 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 297245002308 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 297245002309 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 297245002310 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 297245002311 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 297245002312 Ligand Binding Site [chemical binding]; other site 297245002313 TilS substrate binding domain; Region: TilS; pfam09179 297245002314 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 297245002315 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 297245002316 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 297245002317 catalytic triad [active] 297245002318 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 297245002319 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 297245002320 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 297245002321 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 297245002322 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 297245002323 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 297245002324 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 297245002325 muropeptide transporter; Validated; Region: ampG; cl17669 297245002326 muropeptide transporter; Reviewed; Region: ampG; PRK11902 297245002327 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 297245002328 Quinolinate synthetase A protein; Region: NadA; pfam02445 297245002329 L-aspartate oxidase; Provisional; Region: PRK09077 297245002330 L-aspartate oxidase; Provisional; Region: PRK06175 297245002331 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 297245002332 adenylosuccinate lyase; Provisional; Region: PRK09285 297245002333 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 297245002334 tetramer interface [polypeptide binding]; other site 297245002335 active site 297245002336 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 297245002337 putative transporter; Provisional; Region: PRK11660 297245002338 Sulfate transporter family; Region: Sulfate_transp; pfam00916 297245002339 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 297245002340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 297245002341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 297245002342 active site 297245002343 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 297245002344 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 297245002345 active site 297245002346 phosphoenolpyruvate synthase; Validated; Region: PRK06464 297245002347 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 297245002348 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 297245002349 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 297245002350 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 297245002351 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 297245002352 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 297245002353 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 297245002354 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 297245002355 dimerization interface [polypeptide binding]; other site 297245002356 active site 297245002357 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 297245002358 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 297245002359 active site 297245002360 homodimer interface [polypeptide binding]; other site 297245002361 hypothetical protein; Provisional; Region: PRK08201 297245002362 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 297245002363 metal binding site [ion binding]; metal-binding site 297245002364 putative dimer interface [polypeptide binding]; other site 297245002365 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 297245002366 rod shape-determining protein MreB; Provisional; Region: PRK13927 297245002367 MreB and similar proteins; Region: MreB_like; cd10225 297245002368 nucleotide binding site [chemical binding]; other site 297245002369 Mg binding site [ion binding]; other site 297245002370 putative protofilament interaction site [polypeptide binding]; other site 297245002371 RodZ interaction site [polypeptide binding]; other site 297245002372 rod shape-determining protein MreC; Provisional; Region: PRK13922 297245002373 rod shape-determining protein MreC; Region: MreC; pfam04085 297245002374 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 297245002375 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 297245002376 pseudouridine synthase; Region: TIGR00093 297245002377 active site 297245002378 isocitrate dehydrogenase; Validated; Region: PRK07362 297245002379 isocitrate dehydrogenase; Reviewed; Region: PRK07006 297245002380 Uncharacterized conserved protein [Function unknown]; Region: COG2127 297245002381 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 297245002382 Clp amino terminal domain; Region: Clp_N; pfam02861 297245002383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245002384 Walker A motif; other site 297245002385 ATP binding site [chemical binding]; other site 297245002386 Walker B motif; other site 297245002387 arginine finger; other site 297245002388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245002389 Walker A motif; other site 297245002390 ATP binding site [chemical binding]; other site 297245002391 Walker B motif; other site 297245002392 arginine finger; other site 297245002393 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 297245002394 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 297245002395 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 297245002396 putative metal binding site; other site 297245002397 O-Antigen ligase; Region: Wzy_C; cl04850 297245002398 Rhomboid family; Region: Rhomboid; cl11446 297245002399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 297245002400 Peptidase family M23; Region: Peptidase_M23; pfam01551 297245002401 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 297245002402 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 297245002403 generic binding surface II; other site 297245002404 generic binding surface I; other site 297245002405 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 297245002406 Sporulation related domain; Region: SPOR; pfam05036 297245002407 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 297245002408 biofilm formation regulator HmsP; Provisional; Region: PRK11829 297245002409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 297245002410 dimerization interface [polypeptide binding]; other site 297245002411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245002412 metal binding site [ion binding]; metal-binding site 297245002413 active site 297245002414 I-site; other site 297245002415 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245002416 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 297245002417 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 297245002418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 297245002419 hypothetical protein; Provisional; Region: PRK06194 297245002420 classical (c) SDRs; Region: SDR_c; cd05233 297245002421 NAD(P) binding site [chemical binding]; other site 297245002422 active site 297245002423 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 297245002424 active site 297245002425 ribulose/triose binding site [chemical binding]; other site 297245002426 phosphate binding site [ion binding]; other site 297245002427 substrate (anthranilate) binding pocket [chemical binding]; other site 297245002428 product (indole) binding pocket [chemical binding]; other site 297245002429 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 297245002430 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 297245002431 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 297245002432 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 297245002433 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 297245002434 glutamine binding [chemical binding]; other site 297245002435 catalytic triad [active] 297245002436 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 297245002437 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 297245002438 Walker A/P-loop; other site 297245002439 ATP binding site [chemical binding]; other site 297245002440 Q-loop/lid; other site 297245002441 ABC transporter signature motif; other site 297245002442 Walker B; other site 297245002443 D-loop; other site 297245002444 H-loop/switch region; other site 297245002445 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 297245002446 OstA-like protein; Region: OstA; pfam03968 297245002447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 297245002448 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 297245002449 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 297245002450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245002451 active site 297245002452 motif I; other site 297245002453 motif II; other site 297245002454 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 297245002455 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 297245002456 putative active site [active] 297245002457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 297245002458 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 297245002459 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 297245002460 Walker A/P-loop; other site 297245002461 ATP binding site [chemical binding]; other site 297245002462 Q-loop/lid; other site 297245002463 ABC transporter signature motif; other site 297245002464 Walker B; other site 297245002465 D-loop; other site 297245002466 H-loop/switch region; other site 297245002467 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 297245002468 Permease; Region: Permease; cl00510 297245002469 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 297245002470 mce related protein; Region: MCE; pfam02470 297245002471 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 297245002472 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 297245002473 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 297245002474 anti sigma factor interaction site; other site 297245002475 regulatory phosphorylation site [posttranslational modification]; other site 297245002476 BolA-like protein; Region: BolA; cl00386 297245002477 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 297245002478 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 297245002479 hinge; other site 297245002480 active site 297245002481 Uncharacterized conserved protein [Function unknown]; Region: COG0327 297245002482 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 297245002483 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 297245002484 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 297245002485 Walker A/P-loop; other site 297245002486 ATP binding site [chemical binding]; other site 297245002487 Q-loop/lid; other site 297245002488 ABC transporter signature motif; other site 297245002489 Walker B; other site 297245002490 D-loop; other site 297245002491 H-loop/switch region; other site 297245002492 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 297245002493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 297245002494 FtsX-like permease family; Region: FtsX; pfam02687 297245002495 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 297245002496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245002497 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245002498 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 297245002499 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 297245002500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245002501 Walker A motif; other site 297245002502 ATP binding site [chemical binding]; other site 297245002503 Walker B motif; other site 297245002504 arginine finger; other site 297245002505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 297245002506 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 297245002507 putative inner membrane peptidase; Provisional; Region: PRK11778 297245002508 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 297245002509 tandem repeat interface [polypeptide binding]; other site 297245002510 oligomer interface [polypeptide binding]; other site 297245002511 active site residues [active] 297245002512 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 297245002513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245002514 Walker A/P-loop; other site 297245002515 ATP binding site [chemical binding]; other site 297245002516 Q-loop/lid; other site 297245002517 ABC transporter signature motif; other site 297245002518 Walker B; other site 297245002519 D-loop; other site 297245002520 H-loop/switch region; other site 297245002521 CcmB protein; Region: CcmB; cl17444 297245002522 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 297245002523 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 297245002524 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 297245002525 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 297245002526 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 297245002527 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 297245002528 catalytic residues [active] 297245002529 central insert; other site 297245002530 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 297245002531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245002532 binding surface 297245002533 TPR motif; other site 297245002534 Dodecin; Region: Dodecin; pfam07311 297245002535 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 297245002536 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 297245002537 active site 297245002538 DNA binding site [nucleotide binding] 297245002539 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 297245002540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245002541 ATP binding site [chemical binding]; other site 297245002542 putative Mg++ binding site [ion binding]; other site 297245002543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245002544 nucleotide binding region [chemical binding]; other site 297245002545 ATP-binding site [chemical binding]; other site 297245002546 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 297245002547 HRDC domain; Region: HRDC; pfam00570 297245002548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 297245002549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 297245002550 active site 297245002551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 297245002552 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 297245002553 substrate binding site [chemical binding]; other site 297245002554 oxyanion hole (OAH) forming residues; other site 297245002555 trimer interface [polypeptide binding]; other site 297245002556 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 297245002557 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 297245002558 substrate binding site [chemical binding]; other site 297245002559 oxyanion hole (OAH) forming residues; other site 297245002560 trimer interface [polypeptide binding]; other site 297245002561 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 297245002562 UbiA prenyltransferase family; Region: UbiA; pfam01040 297245002563 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 297245002564 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 297245002565 G1 box; other site 297245002566 putative GEF interaction site [polypeptide binding]; other site 297245002567 GTP/Mg2+ binding site [chemical binding]; other site 297245002568 Switch I region; other site 297245002569 G2 box; other site 297245002570 G3 box; other site 297245002571 Switch II region; other site 297245002572 G4 box; other site 297245002573 G5 box; other site 297245002574 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 297245002575 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 297245002576 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 297245002577 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 297245002578 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 297245002579 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 297245002580 ligand binding site [chemical binding]; other site 297245002581 homodimer interface [polypeptide binding]; other site 297245002582 NAD(P) binding site [chemical binding]; other site 297245002583 trimer interface B [polypeptide binding]; other site 297245002584 trimer interface A [polypeptide binding]; other site 297245002585 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 297245002586 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 297245002587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245002588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245002589 metal binding site [ion binding]; metal-binding site 297245002590 active site 297245002591 I-site; other site 297245002592 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 297245002593 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 297245002594 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 297245002595 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 297245002596 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 297245002597 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 297245002598 metal binding site [ion binding]; metal-binding site 297245002599 dimer interface [polypeptide binding]; other site 297245002600 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 297245002601 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 297245002602 trimer interface [polypeptide binding]; other site 297245002603 active site 297245002604 substrate binding site [chemical binding]; other site 297245002605 CoA binding site [chemical binding]; other site 297245002606 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 297245002607 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 297245002608 putative acyl-acceptor binding pocket; other site 297245002609 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 297245002610 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 297245002611 homodimer interface [polypeptide binding]; other site 297245002612 substrate-cofactor binding pocket; other site 297245002613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245002614 catalytic residue [active] 297245002615 PAS fold; Region: PAS_7; pfam12860 297245002616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245002617 PAS domain; Region: PAS_9; pfam13426 297245002618 putative active site [active] 297245002619 heme pocket [chemical binding]; other site 297245002620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245002621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245002622 metal binding site [ion binding]; metal-binding site 297245002623 active site 297245002624 I-site; other site 297245002625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245002626 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 297245002627 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 297245002628 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 297245002629 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 297245002630 FAD binding domain; Region: FAD_binding_4; pfam01565 297245002631 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 297245002632 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 297245002633 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245002634 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 297245002635 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 297245002636 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 297245002637 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 297245002638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 297245002639 minor groove reading motif; other site 297245002640 helix-hairpin-helix signature motif; other site 297245002641 substrate binding pocket [chemical binding]; other site 297245002642 active site 297245002643 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 297245002644 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 297245002645 DNA binding and oxoG recognition site [nucleotide binding] 297245002646 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 297245002647 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 297245002648 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 297245002649 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 297245002650 protein binding site [polypeptide binding]; other site 297245002651 Isochorismatase family; Region: Isochorismatase; pfam00857 297245002652 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 297245002653 catalytic triad [active] 297245002654 dimer interface [polypeptide binding]; other site 297245002655 conserved cis-peptide bond; other site 297245002656 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 297245002657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245002658 NAD(P) binding site [chemical binding]; other site 297245002659 active site 297245002660 FlgN protein; Region: FlgN; pfam05130 297245002661 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 297245002662 SAF-like; Region: SAF_2; pfam13144 297245002663 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 297245002664 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 297245002665 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245002666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 297245002667 nucleotide binding site [chemical binding]; other site 297245002668 Type III pantothenate kinase; Region: Pan_kinase; cl17198 297245002669 cell division protein MraZ; Reviewed; Region: PRK00326 297245002670 MraZ protein; Region: MraZ; pfam02381 297245002671 MraZ protein; Region: MraZ; pfam02381 297245002672 MraW methylase family; Region: Methyltransf_5; cl17771 297245002673 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 297245002674 Cell division protein FtsL; Region: FtsL; pfam04999 297245002675 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 297245002676 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 297245002677 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 297245002678 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 297245002679 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 297245002680 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 297245002681 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 297245002682 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 297245002683 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 297245002684 ligand binding site [chemical binding]; other site 297245002685 NAD binding site [chemical binding]; other site 297245002686 catalytic site [active] 297245002687 homodimer interface [polypeptide binding]; other site 297245002688 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 297245002689 Peptidase family M50; Region: Peptidase_M50; pfam02163 297245002690 active site 297245002691 putative substrate binding region [chemical binding]; other site 297245002692 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 297245002693 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 297245002694 active site 297245002695 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 297245002696 Ligand binding site [chemical binding]; other site 297245002697 Electron transfer flavoprotein domain; Region: ETF; pfam01012 297245002698 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 297245002699 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 297245002700 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 297245002701 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 297245002702 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 297245002703 hexamer interface [polypeptide binding]; other site 297245002704 ligand binding site [chemical binding]; other site 297245002705 putative active site [active] 297245002706 NAD(P) binding site [chemical binding]; other site 297245002707 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 297245002708 Transglycosylase; Region: Transgly; pfam00912 297245002709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 297245002710 Cell division protein FtsA; Region: FtsA; cl17206 297245002711 Competence protein A; Region: Competence_A; pfam11104 297245002712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 297245002713 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 297245002714 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 297245002715 Pilus assembly protein, PilO; Region: PilO; pfam04350 297245002716 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 297245002717 Pilus assembly protein, PilP; Region: PilP; pfam04351 297245002718 AMIN domain; Region: AMIN; pfam11741 297245002719 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 297245002720 Secretin and TonB N terminus short domain; Region: STN; smart00965 297245002721 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 297245002722 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 297245002723 shikimate kinase; Reviewed; Region: aroK; PRK00131 297245002724 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 297245002725 ADP binding site [chemical binding]; other site 297245002726 magnesium binding site [ion binding]; other site 297245002727 putative shikimate binding site; other site 297245002728 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 297245002729 active site 297245002730 dimer interface [polypeptide binding]; other site 297245002731 metal binding site [ion binding]; metal-binding site 297245002732 AAA domain; Region: AAA_22; pfam13401 297245002733 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 297245002734 Sporulation related domain; Region: SPOR; pfam05036 297245002735 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 297245002736 Ligand Binding Site [chemical binding]; other site 297245002737 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 297245002738 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 297245002739 active site 297245002740 Riboflavin kinase; Region: Flavokinase; smart00904 297245002741 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 297245002742 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245002743 active site 297245002744 HIGH motif; other site 297245002745 nucleotide binding site [chemical binding]; other site 297245002746 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 297245002747 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 297245002748 active site 297245002749 KMSKS motif; other site 297245002750 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 297245002751 tRNA binding surface [nucleotide binding]; other site 297245002752 anticodon binding site; other site 297245002753 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 297245002754 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 297245002755 lipoprotein signal peptidase; Provisional; Region: PRK14787 297245002756 Class I aldolases; Region: Aldolase_Class_I; cl17187 297245002757 catalytic residue [active] 297245002758 GTPase Era; Reviewed; Region: era; PRK00089 297245002759 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 297245002760 G1 box; other site 297245002761 GTP/Mg2+ binding site [chemical binding]; other site 297245002762 Switch I region; other site 297245002763 G2 box; other site 297245002764 Switch II region; other site 297245002765 G3 box; other site 297245002766 G4 box; other site 297245002767 G5 box; other site 297245002768 KH domain; Region: KH_2; pfam07650 297245002769 Recombination protein O N terminal; Region: RecO_N; pfam11967 297245002770 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 297245002771 Recombination protein O C terminal; Region: RecO_C; pfam02565 297245002772 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 297245002773 active site 297245002774 hydrophilic channel; other site 297245002775 dimerization interface [polypeptide binding]; other site 297245002776 catalytic residues [active] 297245002777 active site lid [active] 297245002778 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 297245002779 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 297245002780 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 297245002781 dimer interface [polypeptide binding]; other site 297245002782 PYR/PP interface [polypeptide binding]; other site 297245002783 TPP binding site [chemical binding]; other site 297245002784 substrate binding site [chemical binding]; other site 297245002785 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 297245002786 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 297245002787 TPP-binding site [chemical binding]; other site 297245002788 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 297245002789 YccA-like proteins; Region: YccA_like; cd10433 297245002790 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 297245002791 nitrilase; Region: PLN02798 297245002792 putative active site [active] 297245002793 catalytic triad [active] 297245002794 dimer interface [polypeptide binding]; other site 297245002795 protease TldD; Provisional; Region: tldD; PRK10735 297245002796 hypothetical protein; Provisional; Region: PRK10279 297245002797 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 297245002798 active site 297245002799 nucleophile elbow; other site 297245002800 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 297245002801 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 297245002802 acyl-activating enzyme (AAE) consensus motif; other site 297245002803 putative AMP binding site [chemical binding]; other site 297245002804 putative active site [active] 297245002805 putative CoA binding site [chemical binding]; other site 297245002806 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 297245002807 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 297245002808 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245002809 ATP binding site [chemical binding]; other site 297245002810 putative Mg++ binding site [ion binding]; other site 297245002811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245002812 nucleotide binding region [chemical binding]; other site 297245002813 ATP-binding site [chemical binding]; other site 297245002814 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 297245002815 RmuC family; Region: RmuC; pfam02646 297245002816 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 297245002817 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 297245002818 nucleotide binding pocket [chemical binding]; other site 297245002819 K-X-D-G motif; other site 297245002820 catalytic site [active] 297245002821 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 297245002822 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 297245002823 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 297245002824 Dimer interface [polypeptide binding]; other site 297245002825 BRCT sequence motif; other site 297245002826 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 297245002827 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 297245002828 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 297245002829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245002830 dimer interface [polypeptide binding]; other site 297245002831 conserved gate region; other site 297245002832 putative PBP binding loops; other site 297245002833 ABC-ATPase subunit interface; other site 297245002834 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 297245002835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245002836 dimer interface [polypeptide binding]; other site 297245002837 conserved gate region; other site 297245002838 putative PBP binding loops; other site 297245002839 ABC-ATPase subunit interface; other site 297245002840 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 297245002841 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 297245002842 putative active site [active] 297245002843 putative PHP Thumb interface [polypeptide binding]; other site 297245002844 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 297245002845 generic binding surface II; other site 297245002846 generic binding surface I; other site 297245002847 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 297245002848 UbiA prenyltransferase family; Region: UbiA; pfam01040 297245002849 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 297245002850 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 297245002851 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 297245002852 NAD(P) binding site [chemical binding]; other site 297245002853 homodimer interface [polypeptide binding]; other site 297245002854 substrate binding site [chemical binding]; other site 297245002855 active site 297245002856 Similar to C-terminal part of unknown Legionella protein;hypothetical protein 297245002857 Similar to N-terminal part of unknown Legionella protein;hypothetical protein 297245002858 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 297245002859 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 297245002860 nucleotide binding site [chemical binding]; other site 297245002861 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 297245002862 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 297245002863 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 297245002864 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 297245002865 Catalytic site [active] 297245002866 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 297245002867 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 297245002868 active site 297245002869 DNA binding site [nucleotide binding] 297245002870 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 297245002871 Antirestriction protein (ArdA); Region: ArdA; pfam07275 297245002872 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 297245002873 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 297245002874 dimer interface [polypeptide binding]; other site 297245002875 ssDNA binding site [nucleotide binding]; other site 297245002876 tetramer (dimer of dimers) interface [polypeptide binding]; other site 297245002877 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 297245002878 Integrase; Region: Integrase_1; pfam12835 297245002879 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 297245002880 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 297245002881 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 297245002882 putative active site [active] 297245002883 putative NTP binding site [chemical binding]; other site 297245002884 putative nucleic acid binding site [nucleotide binding]; other site 297245002885 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 297245002886 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 297245002887 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 297245002888 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 297245002889 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 297245002890 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 297245002891 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 297245002892 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 297245002893 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 297245002894 Domain of unknown function DUF87; Region: DUF87; pfam01935 297245002895 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 297245002896 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 297245002897 basic region leucin zipper; Region: BRLZ; smart00338 297245002898 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 297245002899 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 297245002900 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 297245002901 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 297245002902 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 297245002903 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 297245002904 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 297245002905 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 297245002906 Global regulator protein family; Region: CsrA; pfam02599 297245002907 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 297245002908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245002909 non-specific DNA binding site [nucleotide binding]; other site 297245002910 salt bridge; other site 297245002911 sequence-specific DNA binding site [nucleotide binding]; other site 297245002912 Similar to C-terminal part of copper efflux ATPase;hypothetical protein 297245002913 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 297245002914 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 297245002915 Predicted membrane protein [Function unknown]; Region: COG3212 297245002916 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 297245002917 Similar to C-terminal part of arginine-binding periplasmic protein;hypothetical protein 297245002918 Similar to central part of arginine-binding periplasmic protein;hypothetical protein 297245002919 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 297245002920 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 297245002921 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 297245002922 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245002923 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 297245002924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 297245002925 dimerization interface [polypeptide binding]; other site 297245002926 putative DNA binding site [nucleotide binding]; other site 297245002927 putative Zn2+ binding site [ion binding]; other site 297245002928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 297245002929 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 297245002930 metal-binding site [ion binding] 297245002931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 297245002932 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 297245002933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245002934 non-specific DNA binding site [nucleotide binding]; other site 297245002935 salt bridge; other site 297245002936 sequence-specific DNA binding site [nucleotide binding]; other site 297245002937 Heme NO binding; Region: HNOB; pfam07700 297245002938 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245002939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245002940 metal binding site [ion binding]; metal-binding site 297245002941 active site 297245002942 I-site; other site 297245002943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245002944 similar to N-terminal part of polyhydroxyalkanoic-acid-synthase (the first 30 aa are missing);hypothetical protein 297245002945 similar to C-terminal part of polyhydroxyalkanoic-acid-synthase;hypothetical protein 297245002946 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 297245002947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245002948 NAD(P) binding site [chemical binding]; other site 297245002949 active site 297245002950 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 297245002951 DNA-binding site [nucleotide binding]; DNA binding site 297245002952 RNA-binding motif; other site 297245002953 Similar to C-terminal part of unknown protein;hypothetical protein 297245002954 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245002955 Sel1-like repeats; Region: SEL1; smart00671 297245002956 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245002957 Sel1-like repeats; Region: SEL1; smart00671 297245002958 Sel1-like repeats; Region: SEL1; smart00671 297245002959 Sel1-like repeats; Region: SEL1; smart00671 297245002960 Sel1-like repeats; Region: SEL1; smart00671 297245002961 Sel1-like repeats; Region: SEL1; smart00671 297245002962 citrate-proton symporter; Provisional; Region: PRK15075 297245002963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245002964 putative substrate translocation pore; other site 297245002965 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 297245002966 active site 297245002967 catalytic residues [active] 297245002968 metal binding site [ion binding]; metal-binding site 297245002969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245002970 non-specific DNA binding site [nucleotide binding]; other site 297245002971 salt bridge; other site 297245002972 sequence-specific DNA binding site [nucleotide binding]; other site 297245002973 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 297245002974 integrase; Provisional; Region: PRK09692 297245002975 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 297245002976 active site 297245002977 Int/Topo IB signature motif; other site 297245002978 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 297245002979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245002980 ATP binding site [chemical binding]; other site 297245002981 putative Mg++ binding site [ion binding]; other site 297245002982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245002983 nucleotide binding region [chemical binding]; other site 297245002984 ATP-binding site [chemical binding]; other site 297245002985 Restriction endonuclease; Region: Mrr_cat; pfam04471 297245002986 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 297245002987 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245002988 ligand binding site [chemical binding]; other site 297245002989 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 297245002990 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 297245002991 dimer interface [polypeptide binding]; other site 297245002992 putative CheW interface [polypeptide binding]; other site 297245002993 Helix-turn-helix domain; Region: HTH_17; cl17695 297245002994 Domain of unknown function (DUF927); Region: DUF927; pfam06048 297245002995 Integrase; Region: Integrase_1; pfam12835 297245002996 Transposase; Region: HTH_Tnp_1; pfam01527 297245002997 putative transposase OrfB; Reviewed; Region: PHA02517 297245002998 HTH-like domain; Region: HTH_21; pfam13276 297245002999 Integrase core domain; Region: rve; pfam00665 297245003000 Integrase core domain; Region: rve_3; pfam13683 297245003001 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 297245003002 Predicted transcriptional regulator [Transcription]; Region: COG4190 297245003003 Helix-turn-helix domain; Region: HTH_20; pfam12840 297245003004 RelB antitoxin; Region: RelB; cl01171 297245003005 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 297245003006 active site 297245003007 DNA binding site [nucleotide binding] 297245003008 Int/Topo IB signature motif; other site 297245003009 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 297245003010 RmuC family; Region: RmuC; pfam02646 297245003011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245003012 salt bridge; other site 297245003013 non-specific DNA binding site [nucleotide binding]; other site 297245003014 sequence-specific DNA binding site [nucleotide binding]; other site 297245003015 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 297245003016 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 297245003017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245003018 sequence-specific DNA binding site [nucleotide binding]; other site 297245003019 salt bridge; other site 297245003020 Similar to C-terminal part of hypothetical protein;hypothetical protein 297245003021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245003022 Coenzyme A binding pocket [chemical binding]; other site 297245003023 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 297245003024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245003025 motif II; other site 297245003026 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 297245003027 Similar to N-terminal part of secreted protein;hypothetical protein 297245003028 Similar to C-terminal part of secreted protein;hypothetical protein 297245003029 Phosphotransferase enzyme family; Region: APH; pfam01636 297245003030 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 297245003031 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 297245003032 methionine sulfoxide reductase B; Provisional; Region: PRK00222 297245003033 SelR domain; Region: SelR; pfam01641 297245003034 Predicted membrane protein [Function unknown]; Region: COG4325 297245003035 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 297245003036 EamA-like transporter family; Region: EamA; cl17759 297245003037 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245003038 Transposase; Region: HTH_Tnp_1; pfam01527 297245003039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 297245003040 putative transposase OrfB; Reviewed; Region: PHA02517 297245003041 HTH-like domain; Region: HTH_21; pfam13276 297245003042 Integrase core domain; Region: rve; pfam00665 297245003043 Integrase core domain; Region: rve_3; pfam13683 297245003044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245003045 PAS domain; Region: PAS_9; pfam13426 297245003046 putative active site [active] 297245003047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245003048 PAS domain; Region: PAS_9; pfam13426 297245003049 putative active site [active] 297245003050 heme pocket [chemical binding]; other site 297245003051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245003052 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245003053 metal binding site [ion binding]; metal-binding site 297245003054 active site 297245003055 I-site; other site 297245003056 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245003057 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 297245003058 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 297245003059 tetramer interface [polypeptide binding]; other site 297245003060 dimer interface [polypeptide binding]; other site 297245003061 similar to other protein, ATP binding site (C-terminal part, truncated);hypothetical protein 297245003062 similar to other proteins (N-terminal part, truncated);hypothetical protein 297245003063 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 297245003064 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 297245003065 active site 297245003066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245003067 Coenzyme A binding pocket [chemical binding]; other site 297245003068 Beta-lactamase; Region: Beta-lactamase; pfam00144 297245003069 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 297245003070 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 297245003071 catalytic core [active] 297245003072 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 297245003073 N-acetyl-D-glucosamine binding site [chemical binding]; other site 297245003074 catalytic residue [active] 297245003075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245003076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245003077 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245003078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245003079 substrate binding pocket [chemical binding]; other site 297245003080 membrane-bound complex binding site; other site 297245003081 hinge residues; other site 297245003082 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245003083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245003084 substrate binding pocket [chemical binding]; other site 297245003085 membrane-bound complex binding site; other site 297245003086 hinge residues; other site 297245003087 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 297245003088 Soluble P-type ATPase [General function prediction only]; Region: COG4087 297245003089 putative cation:proton antiport protein; Provisional; Region: PRK10669 297245003090 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 297245003091 TrkA-N domain; Region: TrkA_N; pfam02254 297245003092 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 297245003093 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 297245003094 acyl-activating enzyme (AAE) consensus motif; other site 297245003095 AMP binding site [chemical binding]; other site 297245003096 active site 297245003097 CoA binding site [chemical binding]; other site 297245003098 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 297245003099 nucleoside/Zn binding site; other site 297245003100 dimer interface [polypeptide binding]; other site 297245003101 catalytic motif [active] 297245003102 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 297245003103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 297245003104 dimerization interface [polypeptide binding]; other site 297245003105 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 297245003106 cyclase homology domain; Region: CHD; cd07302 297245003107 nucleotidyl binding site; other site 297245003108 metal binding site [ion binding]; metal-binding site 297245003109 dimer interface [polypeptide binding]; other site 297245003110 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 297245003111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245003112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245003113 S-adenosylmethionine binding site [chemical binding]; other site 297245003114 Homeodomain-like domain; Region: HTH_23; pfam13384 297245003115 Winged helix-turn helix; Region: HTH_29; pfam13551 297245003116 Winged helix-turn helix; Region: HTH_33; pfam13592 297245003117 DDE superfamily endonuclease; Region: DDE_3; pfam13358 297245003118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 297245003119 Nitronate monooxygenase; Region: NMO; pfam03060 297245003120 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 297245003121 FMN binding site [chemical binding]; other site 297245003122 substrate binding site [chemical binding]; other site 297245003123 putative catalytic residue [active] 297245003124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 297245003125 COQ9; Region: COQ9; pfam08511 297245003126 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 297245003127 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 297245003128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 297245003129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 297245003130 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 297245003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245003132 dimer interface [polypeptide binding]; other site 297245003133 conserved gate region; other site 297245003134 putative PBP binding loops; other site 297245003135 ABC-ATPase subunit interface; other site 297245003136 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 297245003137 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 297245003138 Walker A/P-loop; other site 297245003139 ATP binding site [chemical binding]; other site 297245003140 Q-loop/lid; other site 297245003141 ABC transporter signature motif; other site 297245003142 Walker B; other site 297245003143 D-loop; other site 297245003144 H-loop/switch region; other site 297245003145 TOBE domain; Region: TOBE_2; pfam08402 297245003146 short chain dehydrogenase; Provisional; Region: PRK08219 297245003147 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 297245003148 NADP binding site [chemical binding]; other site 297245003149 active site 297245003150 steroid binding site; other site 297245003151 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 297245003152 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 297245003153 active site 297245003154 Zn binding site [ion binding]; other site 297245003155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245003156 Coenzyme A binding pocket [chemical binding]; other site 297245003157 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 297245003158 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 297245003159 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 297245003160 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 297245003161 DNA binding site [nucleotide binding] 297245003162 active site 297245003163 probable polyamine oxidase; Region: PLN02268 297245003164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 297245003165 pyruvate decarboxylase; Region: PLN02573 297245003166 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 297245003167 dimer interface [polypeptide binding]; other site 297245003168 PYR/PP interface [polypeptide binding]; other site 297245003169 TPP binding site [chemical binding]; other site 297245003170 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 297245003171 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 297245003172 TPP-binding site [chemical binding]; other site 297245003173 dimer interface [polypeptide binding]; other site 297245003174 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 297245003175 Peptidase family M28; Region: Peptidase_M28; pfam04389 297245003176 metal binding site [ion binding]; metal-binding site 297245003177 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245003178 Putative serine esterase (DUF676); Region: DUF676; pfam05057 297245003179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245003180 active site 297245003181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003182 metabolite-proton symporter; Region: 2A0106; TIGR00883 297245003183 putative substrate translocation pore; other site 297245003184 acetylornithine deacetylase; Provisional; Region: PRK07522 297245003185 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 297245003186 metal binding site [ion binding]; metal-binding site 297245003187 putative dimer interface [polypeptide binding]; other site 297245003188 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 297245003189 Sugar specificity; other site 297245003190 Pyrimidine base specificity; other site 297245003191 ATP-binding site [chemical binding]; other site 297245003192 7kD viral coat protein; Region: 7kD_coat; pfam02495 297245003193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 297245003194 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 297245003195 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245003196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245003197 metal binding site [ion binding]; metal-binding site 297245003198 active site 297245003199 I-site; other site 297245003200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245003201 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 297245003202 putative ligand binding pocket/active site [active] 297245003203 putative metal binding site [ion binding]; other site 297245003204 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 297245003205 AMMECR1; Region: AMMECR1; pfam01871 297245003206 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 297245003207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245003208 FeS/SAM binding site; other site 297245003209 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245003210 Sel1-like repeats; Region: SEL1; smart00671 297245003211 Sel1-like repeats; Region: SEL1; smart00671 297245003212 Sel1-like repeats; Region: SEL1; smart00671 297245003213 Sel1-like repeats; Region: SEL1; smart00671 297245003214 Sel1-like repeats; Region: SEL1; smart00671 297245003215 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245003216 Sel1-like repeats; Region: SEL1; smart00671 297245003217 Sel1-like repeats; Region: SEL1; smart00671 297245003218 Sel1-like repeats; Region: SEL1; smart00671 297245003219 Sel1-like repeats; Region: SEL1; smart00671 297245003220 Sel1-like repeats; Region: SEL1; smart00671 297245003221 Sel1-like repeats; Region: SEL1; smart00671 297245003222 Sel1-like repeats; Region: SEL1; smart00671 297245003223 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 297245003224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245003225 dimer interface [polypeptide binding]; other site 297245003226 phosphorylation site [posttranslational modification] 297245003227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245003228 ATP binding site [chemical binding]; other site 297245003229 Mg2+ binding site [ion binding]; other site 297245003230 G-X-G motif; other site 297245003231 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 297245003232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245003233 active site 297245003234 phosphorylation site [posttranslational modification] 297245003235 intermolecular recognition site; other site 297245003236 dimerization interface [polypeptide binding]; other site 297245003237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245003238 Walker A motif; other site 297245003239 ATP binding site [chemical binding]; other site 297245003240 Walker B motif; other site 297245003241 arginine finger; other site 297245003242 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 297245003243 AsnC family; Region: AsnC_trans_reg; pfam01037 297245003244 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245003245 Peptidase family M48; Region: Peptidase_M48; pfam01435 297245003246 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 297245003247 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 297245003248 catalytic motif [active] 297245003249 Zn binding site [ion binding]; other site 297245003250 RibD C-terminal domain; Region: RibD_C; cl17279 297245003251 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 297245003252 Lumazine binding domain; Region: Lum_binding; pfam00677 297245003253 Lumazine binding domain; Region: Lum_binding; pfam00677 297245003254 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 297245003255 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 297245003256 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 297245003257 dimerization interface [polypeptide binding]; other site 297245003258 active site 297245003259 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 297245003260 homopentamer interface [polypeptide binding]; other site 297245003261 active site 297245003262 CTP synthetase; Validated; Region: pyrG; PRK05380 297245003263 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 297245003264 Catalytic site [active] 297245003265 active site 297245003266 UTP binding site [chemical binding]; other site 297245003267 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 297245003268 active site 297245003269 putative oxyanion hole; other site 297245003270 catalytic triad [active] 297245003271 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 297245003272 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 297245003273 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 297245003274 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 297245003275 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 297245003276 recombination associated protein; Reviewed; Region: rdgC; PRK00321 297245003277 K+ potassium transporter; Region: K_trans; pfam02705 297245003278 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 297245003279 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 297245003280 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 297245003281 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 297245003282 putative RNA binding site [nucleotide binding]; other site 297245003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245003284 S-adenosylmethionine binding site [chemical binding]; other site 297245003285 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 297245003286 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 297245003287 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 297245003288 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 297245003289 conserved cys residue [active] 297245003290 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 297245003291 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 297245003292 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 297245003293 metal binding site [ion binding]; metal-binding site 297245003294 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 297245003295 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 297245003296 substrate binding site [chemical binding]; other site 297245003297 glutamase interaction surface [polypeptide binding]; other site 297245003298 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 297245003299 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 297245003300 catalytic residues [active] 297245003301 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 297245003302 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 297245003303 putative active site [active] 297245003304 oxyanion strand; other site 297245003305 catalytic triad [active] 297245003306 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 297245003307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245003308 active site 297245003309 motif I; other site 297245003310 motif II; other site 297245003311 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 297245003312 putative active site pocket [active] 297245003313 4-fold oligomerization interface [polypeptide binding]; other site 297245003314 metal binding residues [ion binding]; metal-binding site 297245003315 3-fold/trimer interface [polypeptide binding]; other site 297245003316 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 297245003317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 297245003318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245003319 homodimer interface [polypeptide binding]; other site 297245003320 catalytic residue [active] 297245003321 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 297245003322 histidinol dehydrogenase; Region: hisD; TIGR00069 297245003323 NAD binding site [chemical binding]; other site 297245003324 dimerization interface [polypeptide binding]; other site 297245003325 product binding site; other site 297245003326 substrate binding site [chemical binding]; other site 297245003327 zinc binding site [ion binding]; other site 297245003328 catalytic residues [active] 297245003329 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 297245003330 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 297245003331 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 297245003332 Trp repressor protein; Region: Trp_repressor; cl17266 297245003333 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 297245003334 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 297245003335 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 297245003336 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 297245003337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245003338 active site 297245003339 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 297245003340 DNA-binding site [nucleotide binding]; DNA binding site 297245003341 RNA-binding motif; other site 297245003342 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 297245003343 30S subunit binding site; other site 297245003344 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 297245003345 putative deacylase active site [active] 297245003346 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 297245003347 MarR family; Region: MarR_2; pfam12802 297245003348 MarR family; Region: MarR_2; cl17246 297245003349 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 297245003350 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 297245003351 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 297245003352 LysE type translocator; Region: LysE; cl00565 297245003353 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 297245003354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245003355 Coenzyme A binding pocket [chemical binding]; other site 297245003356 Predicted ATPase [General function prediction only]; Region: COG3911 297245003357 AAA domain; Region: AAA_28; pfam13521 297245003358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245003359 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 297245003360 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 297245003361 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12619 297245003362 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 297245003363 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12628 297245003364 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 297245003365 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 297245003366 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 297245003367 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 297245003368 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 297245003369 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 297245003370 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 297245003371 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 297245003372 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 297245003373 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 297245003374 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 297245003375 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 297245003376 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 297245003377 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12701 297245003378 Flagellar L-ring protein; Region: FlgH; pfam02107 297245003379 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 297245003380 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 297245003381 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12710 297245003382 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 297245003383 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 297245003384 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715 297245003385 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 297245003386 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 297245003387 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 297245003388 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 297245003389 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 297245003390 active site 297245003391 nucleophile elbow; other site 297245003392 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 297245003393 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 297245003394 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 297245003395 transmembrane helices; other site 297245003396 TrkA-C domain; Region: TrkA_C; pfam02080 297245003397 TrkA-C domain; Region: TrkA_C; pfam02080 297245003398 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 297245003399 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 297245003400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 297245003401 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 297245003402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 297245003403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 297245003404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245003405 Walker A/P-loop; other site 297245003406 ATP binding site [chemical binding]; other site 297245003407 Q-loop/lid; other site 297245003408 ABC transporter signature motif; other site 297245003409 Walker B; other site 297245003410 D-loop; other site 297245003411 H-loop/switch region; other site 297245003412 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 297245003413 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 297245003414 malate dehydrogenase; Provisional; Region: PRK13529 297245003415 Malic enzyme, N-terminal domain; Region: malic; pfam00390 297245003416 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 297245003417 NAD(P) binding site [chemical binding]; other site 297245003418 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 297245003419 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 297245003420 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245003421 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 297245003422 Peptidase family M23; Region: Peptidase_M23; pfam01551 297245003423 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 297245003424 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 297245003425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 297245003426 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 297245003427 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 297245003428 DNA binding residues [nucleotide binding] 297245003429 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 297245003430 hypothetical protein; Validated; Region: PRK00110 297245003431 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 297245003432 active site 297245003433 putative DNA-binding cleft [nucleotide binding]; other site 297245003434 dimer interface [polypeptide binding]; other site 297245003435 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 297245003436 RuvA N terminal domain; Region: RuvA_N; pfam01330 297245003437 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 297245003438 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 297245003439 sensor protein QseC; Provisional; Region: PRK10337 297245003440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245003441 dimer interface [polypeptide binding]; other site 297245003442 phosphorylation site [posttranslational modification] 297245003443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245003444 ATP binding site [chemical binding]; other site 297245003445 Mg2+ binding site [ion binding]; other site 297245003446 G-X-G motif; other site 297245003447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245003448 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 297245003449 active site 297245003450 phosphorylation site [posttranslational modification] 297245003451 intermolecular recognition site; other site 297245003452 dimerization interface [polypeptide binding]; other site 297245003453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 297245003454 DNA binding site [nucleotide binding] 297245003455 intracellular septation protein A; Reviewed; Region: PRK00259 297245003456 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 297245003457 N-acetyl-D-glucosamine binding site [chemical binding]; other site 297245003458 catalytic residue [active] 297245003459 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245003460 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 297245003461 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245003462 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 297245003463 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245003464 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 297245003465 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 297245003466 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 297245003467 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 297245003468 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 297245003469 homodimer interface [polypeptide binding]; other site 297245003470 NADP binding site [chemical binding]; other site 297245003471 substrate binding site [chemical binding]; other site 297245003472 FimV protein (N-terminal part) 297245003473 FimV protein (C-terminal part) 297245003474 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 297245003475 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 297245003476 NADH(P)-binding; Region: NAD_binding_10; pfam13460 297245003477 putative NAD(P) binding site [chemical binding]; other site 297245003478 active site 297245003479 DoxX-like family; Region: DoxX_3; pfam13781 297245003480 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 297245003481 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 297245003482 dimerization interface 3.5A [polypeptide binding]; other site 297245003483 active site 297245003484 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 297245003485 active site 297245003486 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 297245003487 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 297245003488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245003489 catalytic residue [active] 297245003490 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 297245003491 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 297245003492 substrate binding site [chemical binding]; other site 297245003493 active site 297245003494 catalytic residues [active] 297245003495 heterodimer interface [polypeptide binding]; other site 297245003496 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 297245003497 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245003498 active site 297245003499 HIGH motif; other site 297245003500 nucleotide binding site [chemical binding]; other site 297245003501 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 297245003502 KMSKS motif; other site 297245003503 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 297245003504 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 297245003505 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 297245003506 active site 297245003507 HIGH motif; other site 297245003508 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 297245003509 KMSKS motif; other site 297245003510 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 297245003511 tRNA binding surface [nucleotide binding]; other site 297245003512 anticodon binding site; other site 297245003513 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 297245003514 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 297245003515 Sulfatase; Region: Sulfatase; pfam00884 297245003516 type II secretion system protein E; Region: type_II_gspE; TIGR02533 297245003517 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 297245003518 Walker A motif; other site 297245003519 ATP binding site [chemical binding]; other site 297245003520 Walker B motif; other site 297245003521 Sporulation related domain; Region: SPOR; pfam05036 297245003522 type II secretion system protein D; Region: type_II_gspD; TIGR02517 297245003523 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 297245003524 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 297245003525 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 297245003526 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 297245003527 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 297245003528 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 297245003529 Cache domain; Region: Cache_1; pfam02743 297245003530 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 297245003531 cyclase homology domain; Region: CHD; cd07302 297245003532 nucleotidyl binding site; other site 297245003533 metal binding site [ion binding]; metal-binding site 297245003534 dimer interface [polypeptide binding]; other site 297245003535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003536 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245003537 putative substrate translocation pore; other site 297245003538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245003540 putative substrate translocation pore; other site 297245003541 IucA / IucC family; Region: IucA_IucC; pfam04183 297245003542 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 297245003543 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 297245003544 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 297245003545 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 297245003546 Sporulation related domain; Region: SPOR; pfam05036 297245003547 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 297245003548 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 297245003549 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 297245003550 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 297245003551 protein binding site [polypeptide binding]; other site 297245003552 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 297245003553 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 297245003554 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 297245003555 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 297245003556 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 297245003557 RNA binding surface [nucleotide binding]; other site 297245003558 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 297245003559 active site 297245003560 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 297245003561 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 297245003562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245003563 FeS/SAM binding site; other site 297245003564 TRAM domain; Region: TRAM; pfam01938 297245003565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003566 putative substrate translocation pore; other site 297245003567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245003568 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245003569 Flagellar protein FliS; Region: FliS; cl00654 297245003570 flagellar capping protein; Provisional; Region: PRK12765 297245003571 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 297245003572 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 297245003573 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 297245003574 flagellin; Provisional; Region: PRK12806 297245003575 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 297245003576 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 297245003577 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 297245003578 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 297245003579 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 297245003580 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 297245003581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 297245003582 Sporulation related domain; Region: SPOR; pfam05036 297245003583 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 297245003584 Colicin V production protein; Region: Colicin_V; pfam02674 297245003585 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 297245003586 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 297245003587 active site 297245003588 (T/H)XGH motif; other site 297245003589 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 297245003590 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 297245003591 Lipopolysaccharide-assembly; Region: LptE; cl01125 297245003592 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 297245003593 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 297245003594 HIGH motif; other site 297245003595 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 297245003596 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245003597 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245003598 active site 297245003599 KMSKS motif; other site 297245003600 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 297245003601 tRNA binding surface [nucleotide binding]; other site 297245003602 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 297245003603 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 297245003604 putative active site [active] 297245003605 catalytic triad [active] 297245003606 putative dimer interface [polypeptide binding]; other site 297245003607 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 297245003608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245003609 aldehyde dehydrogenase family 7 member; Region: PLN02315 297245003610 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 297245003611 tetrameric interface [polypeptide binding]; other site 297245003612 NAD binding site [chemical binding]; other site 297245003613 catalytic residues [active] 297245003614 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 297245003615 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 297245003616 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 297245003617 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 297245003618 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 297245003619 substrate binding site [chemical binding]; other site 297245003620 oxyanion hole (OAH) forming residues; other site 297245003621 trimer interface [polypeptide binding]; other site 297245003622 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 297245003623 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 297245003624 dimer interface [polypeptide binding]; other site 297245003625 active site 297245003626 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245003627 Sel1-like repeats; Region: SEL1; smart00671 297245003628 Sel1-like repeats; Region: SEL1; smart00671 297245003629 Sel1-like repeats; Region: SEL1; smart00671 297245003630 Sel1-like repeats; Region: SEL1; smart00671 297245003631 Sel1-like repeats; Region: SEL1; smart00671 297245003632 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00152 297245003633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245003634 PAS domain; Region: PAS_9; pfam13426 297245003635 putative active site [active] 297245003636 heme pocket [chemical binding]; other site 297245003637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245003638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245003639 metal binding site [ion binding]; metal-binding site 297245003640 active site 297245003641 I-site; other site 297245003642 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245003643 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 297245003644 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 297245003645 type II secretion system protein J; Region: gspJ; TIGR01711 297245003646 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 297245003647 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 297245003648 Type II transport protein GspH; Region: GspH; pfam12019 297245003649 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 297245003650 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 297245003651 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 297245003652 type II secretion system protein F; Region: GspF; TIGR02120 297245003653 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 297245003654 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 297245003655 glutamine synthetase; Provisional; Region: glnA; PRK09469 297245003656 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 297245003657 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 297245003658 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 297245003659 hypothetical protein; Validated; Region: PRK02101 297245003660 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 297245003661 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 297245003662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245003663 catalytic residue [active] 297245003664 heat shock protein 90; Provisional; Region: PRK05218 297245003665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245003666 ATP binding site [chemical binding]; other site 297245003667 Mg2+ binding site [ion binding]; other site 297245003668 G-X-G motif; other site 297245003669 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 297245003670 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 297245003671 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 297245003672 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 297245003673 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 297245003674 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 297245003675 RNA/DNA hybrid binding site [nucleotide binding]; other site 297245003676 active site 297245003677 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 297245003678 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 297245003679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 297245003680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 297245003681 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 297245003682 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 297245003683 POT family; Region: PTR2; cl17359 297245003684 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 297245003685 urocanate hydratase; Provisional; Region: PRK05414 297245003686 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 297245003687 active sites [active] 297245003688 tetramer interface [polypeptide binding]; other site 297245003689 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 297245003690 NAD(P) binding site [chemical binding]; other site 297245003691 catalytic residues [active] 297245003692 short chain dehydrogenase; Provisional; Region: PRK08278 297245003693 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 297245003694 NAD(P) binding site [chemical binding]; other site 297245003695 homodimer interface [polypeptide binding]; other site 297245003696 active site 297245003697 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 297245003698 RNA/DNA hybrid binding site [nucleotide binding]; other site 297245003699 active site 297245003700 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 297245003701 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 297245003702 active site 297245003703 catalytic site [active] 297245003704 substrate binding site [chemical binding]; other site 297245003705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 297245003706 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245003707 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 297245003708 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 297245003709 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 297245003710 Ligand Binding Site [chemical binding]; other site 297245003711 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 297245003712 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 297245003713 putative phosphate acyltransferase; Provisional; Region: PRK05331 297245003714 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 297245003715 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 297245003716 dimer interface [polypeptide binding]; other site 297245003717 active site 297245003718 CoA binding pocket [chemical binding]; other site 297245003719 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 297245003720 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 297245003721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 297245003722 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 297245003723 NAD(P) binding site [chemical binding]; other site 297245003724 homotetramer interface [polypeptide binding]; other site 297245003725 homodimer interface [polypeptide binding]; other site 297245003726 active site 297245003727 acyl carrier protein; Provisional; Region: acpP; PRK00982 297245003728 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 297245003729 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 297245003730 dimer interface [polypeptide binding]; other site 297245003731 active site 297245003732 YceG-like family; Region: YceG; pfam02618 297245003733 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 297245003734 dimerization interface [polypeptide binding]; other site 297245003735 thymidylate kinase; Validated; Region: tmk; PRK00698 297245003736 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 297245003737 TMP-binding site; other site 297245003738 ATP-binding site [chemical binding]; other site 297245003739 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 297245003740 DNA polymerase III subunit delta'; Validated; Region: PRK08485 297245003741 PilZ domain; Region: PilZ; cl01260 297245003742 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 297245003743 active site 297245003744 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 297245003745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245003747 putative substrate translocation pore; other site 297245003748 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 297245003749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003750 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 297245003751 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 297245003752 Ligand binding site; other site 297245003753 Putative Catalytic site; other site 297245003754 DXD motif; other site 297245003755 GtrA-like protein; Region: GtrA; pfam04138 297245003756 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 297245003757 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 297245003758 Phosphotransferase enzyme family; Region: APH; pfam01636 297245003759 active site 297245003760 ATP binding site [chemical binding]; other site 297245003761 substrate binding site [chemical binding]; other site 297245003762 dimer interface [polypeptide binding]; other site 297245003763 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 297245003764 active site 297245003765 catalytic site [active] 297245003766 substrate binding site [chemical binding]; other site 297245003767 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 297245003768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 297245003769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 297245003770 catalytic residue [active] 297245003771 adenylate kinase; Reviewed; Region: adk; PRK00279 297245003772 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 297245003773 AMP-binding site [chemical binding]; other site 297245003774 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 297245003775 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 297245003776 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 297245003777 catalytic residues [active] 297245003778 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 297245003779 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 297245003780 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 297245003781 N- and C-terminal domain interface [polypeptide binding]; other site 297245003782 active site 297245003783 MgATP binding site [chemical binding]; other site 297245003784 catalytic site [active] 297245003785 metal binding site [ion binding]; metal-binding site 297245003786 glycerol binding site [chemical binding]; other site 297245003787 homotetramer interface [polypeptide binding]; other site 297245003788 homodimer interface [polypeptide binding]; other site 297245003789 FBP binding site [chemical binding]; other site 297245003790 protein IIAGlc interface [polypeptide binding]; other site 297245003791 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 297245003792 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 297245003793 dimer interface [polypeptide binding]; other site 297245003794 active site 297245003795 citrylCoA binding site [chemical binding]; other site 297245003796 NADH binding [chemical binding]; other site 297245003797 cationic pore residues; other site 297245003798 oxalacetate/citrate binding site [chemical binding]; other site 297245003799 coenzyme A binding site [chemical binding]; other site 297245003800 catalytic triad [active] 297245003801 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 297245003802 DNA gyrase subunit A; Validated; Region: PRK05560 297245003803 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 297245003804 CAP-like domain; other site 297245003805 active site 297245003806 primary dimer interface [polypeptide binding]; other site 297245003807 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 297245003808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 297245003809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 297245003810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 297245003811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 297245003812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 297245003813 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 297245003814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245003815 catalytic residue [active] 297245003816 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 297245003817 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 297245003818 hinge; other site 297245003819 active site 297245003820 cytidylate kinase; Provisional; Region: cmk; PRK00023 297245003821 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 297245003822 CMP-binding site; other site 297245003823 The sites determining sugar specificity; other site 297245003824 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 297245003825 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 297245003826 RNA binding site [nucleotide binding]; other site 297245003827 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 297245003828 RNA binding site [nucleotide binding]; other site 297245003829 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 297245003830 RNA binding site [nucleotide binding]; other site 297245003831 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 297245003832 RNA binding site [nucleotide binding]; other site 297245003833 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 297245003834 RNA binding site [nucleotide binding]; other site 297245003835 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 297245003836 RNA binding site [nucleotide binding]; other site 297245003837 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 297245003838 tetratricopeptide repeat protein; Provisional; Region: PRK11788 297245003839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245003840 TPR motif; other site 297245003841 binding surface 297245003842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 297245003843 binding surface 297245003844 TPR motif; other site 297245003845 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 297245003846 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 297245003847 inhibitor-cofactor binding pocket; inhibition site 297245003848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245003849 catalytic residue [active] 297245003850 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 297245003851 active site 297245003852 dimer interface [polypeptide binding]; other site 297245003853 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 297245003854 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 297245003855 active site 297245003856 nucleophile elbow; other site 297245003857 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 297245003858 classical (c) SDRs; Region: SDR_c; cd05233 297245003859 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 297245003860 NAD(P) binding site [chemical binding]; other site 297245003861 active site 297245003862 Chorismate lyase; Region: Chor_lyase; cl01230 297245003863 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 297245003864 UbiA prenyltransferase family; Region: UbiA; pfam01040 297245003865 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 297245003866 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 297245003867 threonine synthase; Validated; Region: PRK09225 297245003868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245003869 catalytic residue [active] 297245003870 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 297245003871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245003872 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 297245003873 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 297245003874 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 297245003875 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 297245003876 Predicted membrane protein [Function unknown]; Region: COG2119 297245003877 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 297245003878 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 297245003879 enterobactin exporter EntS; Provisional; Region: PRK10489 297245003880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003881 putative substrate translocation pore; other site 297245003882 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 297245003883 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 297245003884 active site 297245003885 catalytic site [active] 297245003886 tetramer interface [polypeptide binding]; other site 297245003887 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 297245003888 Similar to N-terminal part of oxidoreductase;hypothetical protein 297245003889 Similar to C-terminal part of oxidoreductase;hypothetical protein 297245003890 hypothetical protein 297245003891 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 297245003892 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 297245003893 Soluble P-type ATPase [General function prediction only]; Region: COG4087 297245003894 putative hydrolase; Provisional; Region: PRK10985 297245003895 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 297245003896 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 297245003897 Permutation of conserved domain; other site 297245003898 active site 297245003899 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 297245003900 Penicillinase repressor; Region: Pencillinase_R; pfam03965 297245003901 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 297245003902 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 297245003903 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 297245003904 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 297245003905 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 297245003906 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 297245003907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245003908 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 297245003909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245003910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 297245003911 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 297245003912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245003913 Walker A/P-loop; other site 297245003914 ATP binding site [chemical binding]; other site 297245003915 Q-loop/lid; other site 297245003916 ABC transporter signature motif; other site 297245003917 Walker B; other site 297245003918 D-loop; other site 297245003919 H-loop/switch region; other site 297245003920 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 297245003921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245003922 Coenzyme A binding pocket [chemical binding]; other site 297245003923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245003924 Coenzyme A binding pocket [chemical binding]; other site 297245003925 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 297245003926 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 297245003927 DNA binding residues [nucleotide binding] 297245003928 dimer interface [polypeptide binding]; other site 297245003929 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 297245003930 Homeodomain-like domain; Region: HTH_23; pfam13384 297245003931 Winged helix-turn helix; Region: HTH_29; pfam13551 297245003932 Winged helix-turn helix; Region: HTH_33; pfam13592 297245003933 DDE superfamily endonuclease; Region: DDE_3; pfam13358 297245003934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 297245003935 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 297245003936 DNA binding residues [nucleotide binding] 297245003937 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 297245003938 dimer interface [polypeptide binding]; other site 297245003939 gamma-glutamyl kinase; Provisional; Region: PRK05429 297245003940 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 297245003941 nucleotide binding site [chemical binding]; other site 297245003942 homotetrameric interface [polypeptide binding]; other site 297245003943 putative phosphate binding site [ion binding]; other site 297245003944 putative allosteric binding site; other site 297245003945 PUA domain; Region: PUA; pfam01472 297245003946 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 297245003947 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 297245003948 putative catalytic cysteine [active] 297245003949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245003950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245003951 putative substrate translocation pore; other site 297245003952 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 297245003953 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 297245003954 putative active site [active] 297245003955 Zn binding site [ion binding]; other site 297245003956 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 297245003957 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 297245003958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245003959 S-adenosylmethionine binding site [chemical binding]; other site 297245003960 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 297245003961 RES domain; Region: RES; smart00953 297245003962 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245003963 Leucine-rich repeats; other site 297245003964 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245003965 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 297245003966 Similar to transposase (truncated);hypothetical protein 297245003967 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 297245003968 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 297245003969 dimer interface [polypeptide binding]; other site 297245003970 active site 297245003971 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 297245003972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 297245003973 substrate binding site [chemical binding]; other site 297245003974 oxyanion hole (OAH) forming residues; other site 297245003975 trimer interface [polypeptide binding]; other site 297245003976 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 297245003977 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 297245003978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 297245003979 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245003980 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 297245003981 active site 297245003982 Global regulator protein family; Region: CsrA; pfam02599 297245003983 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 297245003984 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 297245003985 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 297245003986 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 297245003987 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 297245003988 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 297245003989 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 297245003990 putative catalytic residue [active] 297245003991 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 297245003992 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 297245003993 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 297245003994 NAD(P) binding site [chemical binding]; other site 297245003995 catalytic residues [active] 297245003996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 297245003997 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245003998 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 297245003999 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 297245004000 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 297245004001 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 297245004002 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 297245004003 Uncharacterized conserved protein [Function unknown]; Region: COG2938 297245004004 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 297245004005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 297245004006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 297245004007 DNA binding residues [nucleotide binding] 297245004008 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 297245004009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245004010 Walker A motif; other site 297245004011 ATP binding site [chemical binding]; other site 297245004012 Walker B motif; other site 297245004013 arginine finger; other site 297245004014 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 297245004015 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 297245004016 active site 297245004017 TolQ protein; Region: tolQ; TIGR02796 297245004018 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 297245004019 TolR protein; Region: tolR; TIGR02801 297245004020 TolA protein; Region: tolA_full; TIGR02794 297245004021 TolA protein; Region: tolA_full; TIGR02794 297245004022 TonB C terminal; Region: TonB_2; pfam13103 297245004023 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 297245004024 TolB amino-terminal domain; Region: TolB_N; pfam04052 297245004025 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 297245004026 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 297245004027 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 297245004028 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 297245004029 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 297245004030 active site 297245004031 Zn binding site [ion binding]; other site 297245004032 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 297245004033 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 297245004034 ATP binding site [chemical binding]; other site 297245004035 substrate interface [chemical binding]; other site 297245004036 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 297245004037 active site residue [active] 297245004038 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 297245004039 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 297245004040 dimer interface [polypeptide binding]; other site 297245004041 substrate binding site [chemical binding]; other site 297245004042 ATP binding site [chemical binding]; other site 297245004043 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 297245004044 thiamine phosphate binding site [chemical binding]; other site 297245004045 active site 297245004046 pyrophosphate binding site [ion binding]; other site 297245004047 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 297245004048 ThiS interaction site; other site 297245004049 putative active site [active] 297245004050 tetramer interface [polypeptide binding]; other site 297245004051 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 297245004052 thiS-thiF/thiG interaction site; other site 297245004053 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 297245004054 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 297245004055 NMT1/THI5 like; Region: NMT1; pfam09084 297245004056 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 297245004057 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434 297245004058 Uncharacterized conserved protein [Function unknown]; Region: COG0398 297245004059 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 297245004060 mercuric reductase; Validated; Region: PRK06370 297245004061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 297245004062 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 297245004063 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 297245004064 Mechanosensitive ion channel; Region: MS_channel; pfam00924 297245004065 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 297245004066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 297245004067 E3 interaction surface; other site 297245004068 lipoyl attachment site [posttranslational modification]; other site 297245004069 e3 binding domain; Region: E3_binding; pfam02817 297245004070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 297245004071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 297245004072 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 297245004073 alpha subunit interface [polypeptide binding]; other site 297245004074 TPP binding site [chemical binding]; other site 297245004075 heterodimer interface [polypeptide binding]; other site 297245004076 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 297245004077 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 297245004078 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 297245004079 TPP-binding site [chemical binding]; other site 297245004080 tetramer interface [polypeptide binding]; other site 297245004081 heterodimer interface [polypeptide binding]; other site 297245004082 phosphorylation loop region [posttranslational modification] 297245004083 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 297245004084 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 297245004085 chorismate binding enzyme; Region: Chorismate_bind; cl10555 297245004086 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 297245004087 putative active site [active] 297245004088 putative CoA binding site [chemical binding]; other site 297245004089 nudix motif; other site 297245004090 metal binding site [ion binding]; metal-binding site 297245004091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 297245004092 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 297245004093 substrate binding pocket [chemical binding]; other site 297245004094 membrane-bound complex binding site; other site 297245004095 hinge residues; other site 297245004096 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 297245004097 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 297245004098 acyl-activating enzyme (AAE) consensus motif; other site 297245004099 putative AMP binding site [chemical binding]; other site 297245004100 putative active site [active] 297245004101 putative CoA binding site [chemical binding]; other site 297245004102 septum formation inhibitor; Reviewed; Region: minC; PRK00339 297245004103 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 297245004104 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 297245004105 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 297245004106 putative active site [active] 297245004107 putative metal binding site [ion binding]; other site 297245004108 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 297245004109 active site 297245004110 dinuclear metal binding site [ion binding]; other site 297245004111 dimerization interface [polypeptide binding]; other site 297245004112 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 297245004113 active site 297245004114 multimer interface [polypeptide binding]; other site 297245004115 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 297245004116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245004117 FeS/SAM binding site; other site 297245004118 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 297245004119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245004120 binding surface 297245004121 TPR motif; other site 297245004122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245004123 binding surface 297245004124 TPR motif; other site 297245004125 Helix-turn-helix domain; Region: HTH_25; pfam13413 297245004126 histidyl-tRNA synthetase; Region: hisS; TIGR00442 297245004127 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 297245004128 dimer interface [polypeptide binding]; other site 297245004129 motif 1; other site 297245004130 active site 297245004131 motif 2; other site 297245004132 motif 3; other site 297245004133 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 297245004134 anticodon binding site; other site 297245004135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 297245004136 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 297245004137 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 297245004138 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 297245004139 Trp docking motif [polypeptide binding]; other site 297245004140 active site 297245004141 GTP-binding protein Der; Reviewed; Region: PRK00093 297245004142 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 297245004143 G1 box; other site 297245004144 GTP/Mg2+ binding site [chemical binding]; other site 297245004145 Switch I region; other site 297245004146 G2 box; other site 297245004147 Switch II region; other site 297245004148 G3 box; other site 297245004149 G4 box; other site 297245004150 G5 box; other site 297245004151 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 297245004152 G1 box; other site 297245004153 GTP/Mg2+ binding site [chemical binding]; other site 297245004154 Switch I region; other site 297245004155 G2 box; other site 297245004156 G3 box; other site 297245004157 Switch II region; other site 297245004158 G4 box; other site 297245004159 G5 box; other site 297245004160 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 297245004161 Ligand Binding Site [chemical binding]; other site 297245004162 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 297245004163 catalytic center binding site [active] 297245004164 ATP binding site [chemical binding]; other site 297245004165 poly(A) polymerase; Region: pcnB; TIGR01942 297245004166 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 297245004167 active site 297245004168 NTP binding site [chemical binding]; other site 297245004169 metal binding triad [ion binding]; metal-binding site 297245004170 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 297245004171 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 297245004172 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 297245004173 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 297245004174 Rubredoxin [Energy production and conversion]; Region: COG1773 297245004175 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 297245004176 iron binding site [ion binding]; other site 297245004177 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 297245004178 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 297245004179 inhibitor-cofactor binding pocket; inhibition site 297245004180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245004181 catalytic residue [active] 297245004182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004183 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 297245004184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004185 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 297245004186 Uncharacterized conserved protein [Function unknown]; Region: COG4121 297245004187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 297245004188 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 297245004189 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 297245004190 dimer interface [polypeptide binding]; other site 297245004191 Citrate synthase; Region: Citrate_synt; pfam00285 297245004192 active site 297245004193 citrylCoA binding site [chemical binding]; other site 297245004194 oxalacetate/citrate binding site [chemical binding]; other site 297245004195 coenzyme A binding site [chemical binding]; other site 297245004196 catalytic triad [active] 297245004197 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 297245004198 2-methylcitrate dehydratase; Region: prpD; TIGR02330 297245004199 PEP synthetase regulatory protein; Provisional; Region: PRK05339 297245004200 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 297245004201 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 297245004202 ligand binding site [chemical binding]; other site 297245004203 CAAX protease self-immunity; Region: Abi; pfam02517 297245004204 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 297245004205 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 297245004206 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 297245004207 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 297245004208 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 297245004209 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 297245004210 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 297245004211 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 297245004212 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 297245004213 Walker A motif; other site 297245004214 ATP binding site [chemical binding]; other site 297245004215 Walker B motif; other site 297245004216 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 297245004217 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245004218 active site 297245004219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245004220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245004221 metal binding site [ion binding]; metal-binding site 297245004222 active site 297245004223 I-site; other site 297245004224 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245004225 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 297245004226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245004227 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245004228 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 297245004229 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 297245004230 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 297245004231 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 297245004232 Walker A/P-loop; other site 297245004233 ATP binding site [chemical binding]; other site 297245004234 Q-loop/lid; other site 297245004235 ABC transporter signature motif; other site 297245004236 Walker B; other site 297245004237 D-loop; other site 297245004238 H-loop/switch region; other site 297245004239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 297245004240 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 297245004241 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 297245004242 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 297245004243 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 297245004244 active site 297245004245 LssY C-terminus; Region: LssY_C; pfam14067 297245004246 lipoate-protein ligase B; Provisional; Region: PRK14342 297245004247 Protein of unknown function (DUF493); Region: DUF493; pfam04359 297245004248 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 297245004249 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 297245004250 homodimer interface [polypeptide binding]; other site 297245004251 substrate-cofactor binding pocket; other site 297245004252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245004253 catalytic residue [active] 297245004254 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 297245004255 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 297245004256 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 297245004257 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 297245004258 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 297245004259 Sporulation related domain; Region: SPOR; pfam05036 297245004260 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 297245004261 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 297245004262 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 297245004263 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 297245004264 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 297245004265 dimer interface [polypeptide binding]; other site 297245004266 TPP-binding site [chemical binding]; other site 297245004267 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 297245004268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 297245004269 E3 interaction surface; other site 297245004270 lipoyl attachment site [posttranslational modification]; other site 297245004271 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 297245004272 E3 interaction surface; other site 297245004273 lipoyl attachment site [posttranslational modification]; other site 297245004274 e3 binding domain; Region: E3_binding; pfam02817 297245004275 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 297245004276 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 297245004277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 297245004278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 297245004279 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 297245004280 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 297245004281 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 297245004282 Coenzyme A binding pocket [chemical binding]; other site 297245004283 C factor cell-cell signaling protein; Provisional; Region: PRK09009 297245004284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245004285 NAD(P) binding site [chemical binding]; other site 297245004286 active site 297245004287 aminopeptidase N; Provisional; Region: pepN; PRK14015 297245004288 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 297245004289 Zn binding site [ion binding]; other site 297245004290 Dot/Icm substrate protein; Region: SidE; pfam12252 297245004291 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 297245004292 putative active site pocket [active] 297245004293 dimerization interface [polypeptide binding]; other site 297245004294 putative catalytic residue [active] 297245004295 Phosphotransferase enzyme family; Region: APH; pfam01636 297245004296 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 297245004297 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 297245004298 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 297245004299 Pathogenicity locus; Region: Cdd1; pfam11731 297245004300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 297245004301 GAF domain; Region: GAF; pfam01590 297245004302 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 297245004303 cyclase homology domain; Region: CHD; cd07302 297245004304 nucleotidyl binding site; other site 297245004305 metal binding site [ion binding]; metal-binding site 297245004306 dimer interface [polypeptide binding]; other site 297245004307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245004308 Coenzyme A binding pocket [chemical binding]; other site 297245004309 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 297245004310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 297245004311 putative DNA binding site [nucleotide binding]; other site 297245004312 putative Zn2+ binding site [ion binding]; other site 297245004313 AsnC family; Region: AsnC_trans_reg; pfam01037 297245004314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 297245004315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 297245004316 active site 297245004317 ATP binding site [chemical binding]; other site 297245004318 substrate binding site [chemical binding]; other site 297245004319 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 297245004320 substrate binding site [chemical binding]; other site 297245004321 activation loop (A-loop); other site 297245004322 activation loop (A-loop); other site 297245004323 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 297245004324 putative DNA-binding cleft [nucleotide binding]; other site 297245004325 putative DNA clevage site; other site 297245004326 molecular lever; other site 297245004327 CENP-A-nucleosome distal (CAD) centromere subunit; Region: CENP-Q; pfam13094 297245004328 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 297245004329 Mechanosensitive ion channel; Region: MS_channel; pfam00924 297245004330 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 297245004331 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 297245004332 dimer interface [polypeptide binding]; other site 297245004333 anticodon binding site; other site 297245004334 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 297245004335 homodimer interface [polypeptide binding]; other site 297245004336 motif 1; other site 297245004337 active site 297245004338 motif 2; other site 297245004339 GAD domain; Region: GAD; pfam02938 297245004340 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 297245004341 motif 3; other site 297245004342 Uncharacterized conserved protein [Function unknown]; Region: COG2928 297245004343 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 297245004344 AAA domain; Region: AAA_26; pfam13500 297245004345 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 297245004346 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 297245004347 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 297245004348 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 297245004349 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 297245004350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245004351 catalytic residue [active] 297245004352 biotin synthase; Region: bioB; TIGR00433 297245004353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245004354 FeS/SAM binding site; other site 297245004355 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 297245004356 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 297245004357 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 297245004358 inhibitor-cofactor binding pocket; inhibition site 297245004359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245004360 catalytic residue [active] 297245004361 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 297245004362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 297245004363 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 297245004364 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 297245004365 CoA-binding site [chemical binding]; other site 297245004366 ATP-binding [chemical binding]; other site 297245004367 hypothetical protein; Provisional; Region: PRK05287 297245004368 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 297245004369 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 297245004370 active site 297245004371 8-oxo-dGMP binding site [chemical binding]; other site 297245004372 nudix motif; other site 297245004373 metal binding site [ion binding]; metal-binding site 297245004374 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104 297245004375 DEAD/DEAH box helicase; Region: DEAD; pfam00270 297245004376 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 297245004377 SEC-C motif; Region: SEC-C; pfam02810 297245004378 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 297245004379 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 297245004380 FMN binding site [chemical binding]; other site 297245004381 active site 297245004382 catalytic residues [active] 297245004383 substrate binding site [chemical binding]; other site 297245004384 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 297245004385 DHH family; Region: DHH; pfam01368 297245004386 DHHA1 domain; Region: DHHA1; pfam02272 297245004387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 297245004388 aminotransferase; Validated; Region: PRK08175 297245004389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 297245004390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245004391 homodimer interface [polypeptide binding]; other site 297245004392 catalytic residue [active] 297245004393 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 297245004394 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 297245004395 HD domain; Region: HD_4; pfam13328 297245004396 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 297245004397 synthetase active site [active] 297245004398 NTP binding site [chemical binding]; other site 297245004399 metal binding site [ion binding]; metal-binding site 297245004400 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 297245004401 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 297245004402 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 297245004403 TRAM domain; Region: TRAM; pfam01938 297245004404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245004405 S-adenosylmethionine binding site [chemical binding]; other site 297245004406 Helix-turn-helix domain; Region: HTH_17; pfam12728 297245004407 Similar to replication protein;hypothetical protein 297245004408 putative transposase OrfB; Reviewed; Region: PHA02517 297245004409 HTH-like domain; Region: HTH_21; pfam13276 297245004410 Integrase core domain; Region: rve; pfam00665 297245004411 Integrase core domain; Region: rve_3; pfam13683 297245004412 Transposase; Region: HTH_Tnp_1; pfam01527 297245004413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 297245004414 Similar to N-terminal part of replication protein;hypothetical protein 297245004415 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245004416 Leucine-rich repeats; other site 297245004417 Substrate binding site [chemical binding]; other site 297245004418 Leucine rich repeat; Region: LRR_8; pfam13855 297245004419 Leucine rich repeat; Region: LRR_8; pfam13855 297245004420 Leucine rich repeat; Region: LRR_8; pfam13855 297245004421 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245004422 Leucine-rich repeats; other site 297245004423 Substrate binding site [chemical binding]; other site 297245004424 Leucine rich repeat; Region: LRR_8; pfam13855 297245004425 Leucine rich repeat; Region: LRR_8; pfam13855 297245004426 Leucine rich repeat; Region: LRR_8; pfam13855 297245004427 Similar to part of conjugal transfer protein traA;hypothetical protein 297245004428 Similar to transposase;hypothetical protein 297245004429 Similar to transposase;hypothetical protein 297245004430 Transposase; Region: HTH_Tnp_1; pfam01527 297245004431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 297245004432 Similar to N-terminal part of conjugal transfer protein TraA;hypothetical protein 297245004433 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 297245004434 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 297245004435 Similar to C-terminal part of Legionella pneumophila phospholipase C;hypothetical protein 297245004436 putative transporter; Provisional; Region: PRK10504 297245004437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004438 putative substrate translocation pore; other site 297245004439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245004440 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 297245004441 substrate binding site [chemical binding]; other site 297245004442 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 297245004443 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 297245004444 RNA binding surface [nucleotide binding]; other site 297245004445 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 297245004446 probable active site [active] 297245004447 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 297245004448 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 297245004449 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 297245004450 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 297245004451 active site 297245004452 HIGH motif; other site 297245004453 dimer interface [polypeptide binding]; other site 297245004454 KMSKS motif; other site 297245004455 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 297245004456 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 297245004457 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 297245004458 active site 297245004459 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 297245004460 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 297245004461 PhoH-like protein; Region: PhoH; pfam02562 297245004462 metal-binding heat shock protein; Provisional; Region: PRK00016 297245004463 FOG: CBS domain [General function prediction only]; Region: COG0517 297245004464 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 297245004465 Transporter associated domain; Region: CorC_HlyC; smart01091 297245004466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245004467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 297245004468 active site 297245004469 phosphorylation site [posttranslational modification] 297245004470 intermolecular recognition site; other site 297245004471 dimerization interface [polypeptide binding]; other site 297245004472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 297245004473 DNA binding site [nucleotide binding] 297245004474 two-component sensor protein; Provisional; Region: cpxA; PRK09470 297245004475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 297245004476 dimerization interface [polypeptide binding]; other site 297245004477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245004478 dimer interface [polypeptide binding]; other site 297245004479 phosphorylation site [posttranslational modification] 297245004480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245004481 ATP binding site [chemical binding]; other site 297245004482 Mg2+ binding site [ion binding]; other site 297245004483 G-X-G motif; other site 297245004484 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 297245004485 active site 297245004486 catalytic motif [active] 297245004487 Zn binding site [ion binding]; other site 297245004488 purine nucleoside phosphorylase; Provisional; Region: PRK08202 297245004489 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 297245004490 intersubunit interface [polypeptide binding]; other site 297245004491 active site 297245004492 catalytic residue [active] 297245004493 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 297245004494 FAD binding domain; Region: FAD_binding_4; pfam01565 297245004495 Berberine and berberine like; Region: BBE; pfam08031 297245004496 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 297245004497 YceI-like domain; Region: YceI; pfam04264 297245004498 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 297245004499 YceI-like domain; Region: YceI; smart00867 297245004500 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 297245004501 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 297245004502 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 297245004503 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 297245004504 PYR/PP interface [polypeptide binding]; other site 297245004505 dimer interface [polypeptide binding]; other site 297245004506 TPP binding site [chemical binding]; other site 297245004507 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 297245004508 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 297245004509 TPP-binding site; other site 297245004510 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 297245004511 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 297245004512 substrate binding site [chemical binding]; other site 297245004513 ATP binding site [chemical binding]; other site 297245004514 KduI/IolB family; Region: KduI; pfam04962 297245004515 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 297245004516 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 297245004517 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 297245004518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004519 putative substrate translocation pore; other site 297245004520 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 297245004521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004522 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 297245004523 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 297245004524 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 297245004525 active site 297245004526 Zn binding site [ion binding]; other site 297245004527 ATP-grasp domain; Region: ATP-grasp_4; cl17255 297245004528 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 297245004529 Amidinotransferase; Region: Amidinotransf; cl12043 297245004530 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 297245004531 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245004532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 297245004533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245004534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004535 putative substrate translocation pore; other site 297245004536 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 297245004537 Transglycosylase; Region: Transgly; pfam00912 297245004538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 297245004539 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 297245004540 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 297245004541 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 297245004542 MG2 domain; Region: A2M_N; pfam01835 297245004543 Alpha-2-macroglobulin family; Region: A2M; pfam00207 297245004544 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 297245004545 surface patch; other site 297245004546 thioester region; other site 297245004547 specificity defining residues; other site 297245004548 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 297245004549 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 297245004550 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 297245004551 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 297245004552 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 297245004553 active site 297245004554 catalytic site [active] 297245004555 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 297245004556 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 297245004557 active site 297245004558 substrate binding site [chemical binding]; other site 297245004559 cosubstrate binding site; other site 297245004560 catalytic site [active] 297245004561 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 297245004562 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 297245004563 ATP-grasp domain; Region: ATP-grasp_4; cl17255 297245004564 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 297245004565 amidophosphoribosyltransferase; Provisional; Region: PRK09246 297245004566 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 297245004567 active site 297245004568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245004569 active site 297245004570 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 297245004571 ATP binding site [chemical binding]; other site 297245004572 active site 297245004573 substrate binding site [chemical binding]; other site 297245004574 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 297245004575 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 297245004576 putative active site [active] 297245004577 catalytic triad [active] 297245004578 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 297245004579 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 297245004580 dimerization interface [polypeptide binding]; other site 297245004581 putative ATP binding site [chemical binding]; other site 297245004582 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 297245004583 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 297245004584 dimerization interface [polypeptide binding]; other site 297245004585 ATP binding site [chemical binding]; other site 297245004586 Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824 297245004587 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 297245004588 dimerization interface [polypeptide binding]; other site 297245004589 ATP binding site [chemical binding]; other site 297245004590 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 297245004591 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 297245004592 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 297245004593 DsbD alpha interface [polypeptide binding]; other site 297245004594 catalytic residues [active] 297245004595 short chain dehydrogenase; Provisional; Region: PRK05993 297245004596 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 297245004597 NADP binding site [chemical binding]; other site 297245004598 active site 297245004599 steroid binding site; other site 297245004600 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 297245004601 aconitate hydratase; Validated; Region: PRK09277 297245004602 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 297245004603 substrate binding site [chemical binding]; other site 297245004604 ligand binding site [chemical binding]; other site 297245004605 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 297245004606 substrate binding site [chemical binding]; other site 297245004607 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 297245004608 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 297245004609 Proline dehydrogenase; Region: Pro_dh; pfam01619 297245004610 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 297245004611 Glutamate binding site [chemical binding]; other site 297245004612 NAD binding site [chemical binding]; other site 297245004613 catalytic residues [active] 297245004614 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 297245004615 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 297245004616 ProQ/FINO family; Region: ProQ; pfam04352 297245004617 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 297245004618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245004619 S-adenosylmethionine binding site [chemical binding]; other site 297245004620 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 297245004621 ligand binding site [chemical binding]; other site 297245004622 active site 297245004623 NnrS protein; Region: NnrS; cl01258 297245004624 cell division protein MukB; Provisional; Region: mukB; PRK04863 297245004625 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 297245004626 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 297245004627 active site 297245004628 DNA binding site [nucleotide binding] 297245004629 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 297245004630 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 297245004631 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 297245004632 Catalytic site [active] 297245004633 hypothetical protein; Provisional; Region: PRK07338 297245004634 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 297245004635 metal binding site [ion binding]; metal-binding site 297245004636 dimer interface [polypeptide binding]; other site 297245004637 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 297245004638 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 297245004639 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 297245004640 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 297245004641 NAD(P) binding site [chemical binding]; other site 297245004642 catalytic residues [active] 297245004643 succinylarginine dihydrolase; Provisional; Region: PRK13281 297245004644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245004645 Cytochrome c; Region: Cytochrom_C; cl11414 297245004646 ribosome recycling factor; Reviewed; Region: frr; PRK00083 297245004647 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 297245004648 hinge region; other site 297245004649 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 297245004650 putative nucleotide binding site [chemical binding]; other site 297245004651 uridine monophosphate binding site [chemical binding]; other site 297245004652 homohexameric interface [polypeptide binding]; other site 297245004653 elongation factor Ts; Provisional; Region: tsf; PRK09377 297245004654 UBA/TS-N domain; Region: UBA; pfam00627 297245004655 Elongation factor TS; Region: EF_TS; pfam00889 297245004656 Elongation factor TS; Region: EF_TS; pfam00889 297245004657 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 297245004658 rRNA interaction site [nucleotide binding]; other site 297245004659 S8 interaction site; other site 297245004660 putative laminin-1 binding site; other site 297245004661 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 297245004662 dimer interface [polypeptide binding]; other site 297245004663 Protein kinase domain; Region: Pkinase; pfam00069 297245004664 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 297245004665 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245004666 SET domain; Region: SET; pfam00856 297245004667 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245004668 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245004669 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 297245004670 active site 297245004671 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 297245004672 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 297245004673 metal binding triad; other site 297245004674 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 297245004675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 297245004676 Zn2+ binding site [ion binding]; other site 297245004677 Mg2+ binding site [ion binding]; other site 297245004678 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 297245004679 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 297245004680 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 297245004681 nucleoside/Zn binding site; other site 297245004682 dimer interface [polypeptide binding]; other site 297245004683 catalytic motif [active] 297245004684 GMP synthase; Reviewed; Region: guaA; PRK00074 297245004685 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 297245004686 AMP/PPi binding site [chemical binding]; other site 297245004687 candidate oxyanion hole; other site 297245004688 catalytic triad [active] 297245004689 potential glutamine specificity residues [chemical binding]; other site 297245004690 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 297245004691 ATP Binding subdomain [chemical binding]; other site 297245004692 Ligand Binding sites [chemical binding]; other site 297245004693 Dimerization subdomain; other site 297245004694 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 297245004695 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 297245004696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 297245004697 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 297245004698 active site 297245004699 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 297245004700 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 297245004701 Switch I; other site 297245004702 Switch II; other site 297245004703 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 297245004704 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 297245004705 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 297245004706 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 297245004707 active site 297245004708 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 297245004709 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245004710 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 297245004711 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 297245004712 Walker A/P-loop; other site 297245004713 ATP binding site [chemical binding]; other site 297245004714 Q-loop/lid; other site 297245004715 ABC transporter signature motif; other site 297245004716 Walker B; other site 297245004717 D-loop; other site 297245004718 H-loop/switch region; other site 297245004719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 297245004720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245004721 dimer interface [polypeptide binding]; other site 297245004722 conserved gate region; other site 297245004723 putative PBP binding loops; other site 297245004724 ABC-ATPase subunit interface; other site 297245004725 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 297245004726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245004727 dimer interface [polypeptide binding]; other site 297245004728 conserved gate region; other site 297245004729 putative PBP binding loops; other site 297245004730 ABC-ATPase subunit interface; other site 297245004731 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 297245004732 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 297245004733 NAD(P) binding site [chemical binding]; other site 297245004734 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 297245004735 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 297245004736 Cl- selectivity filter; other site 297245004737 Cl- binding residues [ion binding]; other site 297245004738 pore gating glutamate residue; other site 297245004739 dimer interface [polypeptide binding]; other site 297245004740 H+/Cl- coupling transport residue; other site 297245004741 anthranilate synthase; Provisional; Region: PRK13566 297245004742 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 297245004743 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 297245004744 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 297245004745 glutamine binding [chemical binding]; other site 297245004746 catalytic triad [active] 297245004747 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 297245004748 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 297245004749 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 297245004750 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 297245004751 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 297245004752 GatB domain; Region: GatB_Yqey; smart00845 297245004753 Autotransporter beta-domain; Region: Autotransporter; smart00869 297245004754 CHASE2 domain; Region: CHASE2; pfam05226 297245004755 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 297245004756 cyclase homology domain; Region: CHD; cd07302 297245004757 nucleotidyl binding site; other site 297245004758 metal binding site [ion binding]; metal-binding site 297245004759 dimer interface [polypeptide binding]; other site 297245004760 FecR protein; Region: FecR; pfam04773 297245004761 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 297245004762 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 297245004763 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 297245004764 trimerization site [polypeptide binding]; other site 297245004765 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 297245004766 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 297245004767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245004768 catalytic residue [active] 297245004769 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 297245004770 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 297245004771 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 297245004772 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 297245004773 active site 297245004774 dimerization interface [polypeptide binding]; other site 297245004775 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 297245004776 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 297245004777 tandem repeat interface [polypeptide binding]; other site 297245004778 oligomer interface [polypeptide binding]; other site 297245004779 active site residues [active] 297245004780 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 297245004781 Clp amino terminal domain; Region: Clp_N; pfam02861 297245004782 Clp amino terminal domain; Region: Clp_N; pfam02861 297245004783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245004784 Walker A motif; other site 297245004785 ATP binding site [chemical binding]; other site 297245004786 Walker B motif; other site 297245004787 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 297245004788 arginine finger; other site 297245004789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245004790 Walker A motif; other site 297245004791 ATP binding site [chemical binding]; other site 297245004792 Walker B motif; other site 297245004793 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 297245004794 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 297245004795 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 297245004796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 297245004797 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 297245004798 TIGR02099 family protein; Region: TIGR02099 297245004799 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 297245004800 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 297245004801 Flagellar FliJ protein; Region: FliJ; pfam02050 297245004802 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 297245004803 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 297245004804 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 297245004805 Walker A motif/ATP binding site; other site 297245004806 Walker B motif; other site 297245004807 Flagellar assembly protein FliH; Region: FliH; pfam02108 297245004808 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 297245004809 FliG C-terminal domain; Region: FliG_C; pfam01706 297245004810 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 297245004811 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 297245004812 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 297245004813 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 297245004814 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 297245004815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245004816 active site 297245004817 phosphorylation site [posttranslational modification] 297245004818 intermolecular recognition site; other site 297245004819 dimerization interface [polypeptide binding]; other site 297245004820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245004821 Walker A motif; other site 297245004822 ATP binding site [chemical binding]; other site 297245004823 Walker B motif; other site 297245004824 arginine finger; other site 297245004825 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 297245004826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 297245004827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245004828 putative active site [active] 297245004829 heme pocket [chemical binding]; other site 297245004830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245004831 dimer interface [polypeptide binding]; other site 297245004832 phosphorylation site [posttranslational modification] 297245004833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245004834 ATP binding site [chemical binding]; other site 297245004835 G-X-G motif; other site 297245004836 recombination factor protein RarA; Reviewed; Region: PRK13342 297245004837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245004838 Walker A motif; other site 297245004839 ATP binding site [chemical binding]; other site 297245004840 Walker B motif; other site 297245004841 arginine finger; other site 297245004842 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 297245004843 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 297245004844 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 297245004845 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 297245004846 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 297245004847 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 297245004848 thioredoxin reductase; Provisional; Region: PRK10262 297245004849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 297245004850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 297245004851 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 297245004852 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 297245004853 active site residue [active] 297245004854 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 297245004855 rRNA binding site [nucleotide binding]; other site 297245004856 predicted 30S ribosome binding site; other site 297245004857 peptidase PmbA; Provisional; Region: PRK11040 297245004858 Predicted periplasmic protein [Function unknown]; Region: COG3698 297245004859 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 297245004860 Cupin-like domain; Region: Cupin_8; pfam13621 297245004861 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 297245004862 ATP cone domain; Region: ATP-cone; pfam03477 297245004863 ATP cone domain; Region: ATP-cone; pfam03477 297245004864 Class I ribonucleotide reductase; Region: RNR_I; cd01679 297245004865 active site 297245004866 dimer interface [polypeptide binding]; other site 297245004867 catalytic residues [active] 297245004868 effector binding site; other site 297245004869 R2 peptide binding site; other site 297245004870 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 297245004871 dimer interface [polypeptide binding]; other site 297245004872 putative radical transfer pathway; other site 297245004873 diiron center [ion binding]; other site 297245004874 tyrosyl radical; other site 297245004875 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 297245004876 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 297245004877 dimer interface [polypeptide binding]; other site 297245004878 putative anticodon binding site; other site 297245004879 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 297245004880 motif 1; other site 297245004881 active site 297245004882 motif 2; other site 297245004883 motif 3; other site 297245004884 peptide chain release factor 2; Validated; Region: prfB; PRK00578 297245004885 This domain is found in peptide chain release factors; Region: PCRF; smart00937 297245004886 RF-1 domain; Region: RF-1; pfam00472 297245004887 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 297245004888 flagellar motor protein MotD; Reviewed; Region: PRK09038 297245004889 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 297245004890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245004891 ligand binding site [chemical binding]; other site 297245004892 flagellar motor protein; Reviewed; Region: motC; PRK09109 297245004893 flagellar motor protein MotA; Validated; Region: PRK08124 297245004894 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 297245004895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 297245004896 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 297245004897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 297245004898 DNA binding residues [nucleotide binding] 297245004899 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 297245004900 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 297245004901 P-loop; other site 297245004902 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 297245004903 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 297245004904 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 297245004905 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 297245004906 FHIPEP family; Region: FHIPEP; pfam00771 297245004907 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 297245004908 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 297245004909 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 297245004910 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 297245004911 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 297245004912 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 297245004913 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 297245004914 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 297245004915 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 297245004916 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 297245004917 FAD binding domain; Region: FAD_binding_4; pfam01565 297245004918 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 297245004919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245004920 NAD(P) binding site [chemical binding]; other site 297245004921 active site 297245004922 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245004923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245004924 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 297245004925 dimerization interface [polypeptide binding]; other site 297245004926 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 297245004927 GTPase interaction site; other site 297245004928 catalytic residue [active] 297245004929 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 297245004930 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 297245004931 motif 1; other site 297245004932 active site 297245004933 motif 2; other site 297245004934 motif 3; other site 297245004935 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 297245004936 recombination regulator RecX; Reviewed; Region: recX; PRK00117 297245004937 recombinase A; Provisional; Region: recA; PRK09354 297245004938 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 297245004939 hexamer interface [polypeptide binding]; other site 297245004940 Walker A motif; other site 297245004941 ATP binding site [chemical binding]; other site 297245004942 Walker B motif; other site 297245004943 Competence-damaged protein; Region: CinA; pfam02464 297245004944 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 297245004945 MutS domain I; Region: MutS_I; pfam01624 297245004946 MutS domain II; Region: MutS_II; pfam05188 297245004947 MutS domain III; Region: MutS_III; pfam05192 297245004948 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 297245004949 Walker A/P-loop; other site 297245004950 ATP binding site [chemical binding]; other site 297245004951 Q-loop/lid; other site 297245004952 ABC transporter signature motif; other site 297245004953 Walker B; other site 297245004954 D-loop; other site 297245004955 H-loop/switch region; other site 297245004956 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 297245004957 Surface antigen; Region: Bac_surface_Ag; pfam01103 297245004958 Family of unknown function (DUF490); Region: DUF490; pfam04357 297245004959 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 297245004960 dimer interface [polypeptide binding]; other site 297245004961 active site 297245004962 Schiff base residues; other site 297245004963 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 297245004964 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 297245004965 AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259 297245004966 putative catalytic residues [active] 297245004967 putative nucleotide binding site [chemical binding]; other site 297245004968 putative aspartate binding site [chemical binding]; other site 297245004969 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 297245004970 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920 297245004971 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840 297245004972 active site 297245004973 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 297245004974 substrate binding site [chemical binding]; other site 297245004975 catalytic residues [active] 297245004976 dimer interface [polypeptide binding]; other site 297245004977 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 297245004978 Part of AAA domain; Region: AAA_19; pfam13245 297245004979 Family description; Region: UvrD_C_2; pfam13538 297245004980 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 297245004981 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 297245004982 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 297245004983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245004984 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 297245004985 dimerization interface [polypeptide binding]; other site 297245004986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245004987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245004988 putative substrate translocation pore; other site 297245004989 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 297245004990 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 297245004991 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 297245004992 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 297245004993 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 297245004994 Walker A/P-loop; other site 297245004995 ATP binding site [chemical binding]; other site 297245004996 Q-loop/lid; other site 297245004997 ABC transporter signature motif; other site 297245004998 Walker B; other site 297245004999 D-loop; other site 297245005000 H-loop/switch region; other site 297245005001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245005002 Coenzyme A binding pocket [chemical binding]; other site 297245005003 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 297245005004 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 297245005005 quinone interaction residues [chemical binding]; other site 297245005006 active site 297245005007 catalytic residues [active] 297245005008 FMN binding site [chemical binding]; other site 297245005009 substrate binding site [chemical binding]; other site 297245005010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245005011 isovaleryl-CoA dehydrogenase; Region: PLN02519 297245005012 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 297245005013 substrate binding site [chemical binding]; other site 297245005014 FAD binding site [chemical binding]; other site 297245005015 catalytic base [active] 297245005016 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 297245005017 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 297245005018 dimer interface [polypeptide binding]; other site 297245005019 active site 297245005020 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 297245005021 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 297245005022 enoyl-CoA hydratase; Provisional; Region: PRK05995 297245005023 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 297245005024 substrate binding site [chemical binding]; other site 297245005025 oxyanion hole (OAH) forming residues; other site 297245005026 trimer interface [polypeptide binding]; other site 297245005027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 297245005028 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 297245005029 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 297245005030 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 297245005031 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 297245005032 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 297245005033 carboxyltransferase (CT) interaction site; other site 297245005034 biotinylation site [posttranslational modification]; other site 297245005035 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 297245005036 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 297245005037 active site 297245005038 catalytic residues [active] 297245005039 metal binding site [ion binding]; metal-binding site 297245005040 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 297245005041 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 297245005042 acyl-activating enzyme (AAE) consensus motif; other site 297245005043 putative AMP binding site [chemical binding]; other site 297245005044 putative active site [active] 297245005045 putative CoA binding site [chemical binding]; other site 297245005046 VirK protein; Region: VirK; pfam06903 297245005047 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 297245005048 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 297245005049 Walker A/P-loop; other site 297245005050 ATP binding site [chemical binding]; other site 297245005051 Q-loop/lid; other site 297245005052 ABC transporter signature motif; other site 297245005053 Walker B; other site 297245005054 D-loop; other site 297245005055 H-loop/switch region; other site 297245005056 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 297245005057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 297245005058 dimer interface [polypeptide binding]; other site 297245005059 conserved gate region; other site 297245005060 ABC-ATPase subunit interface; other site 297245005061 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 297245005062 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 297245005063 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 297245005064 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 297245005065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245005066 active site 297245005067 motif I; other site 297245005068 motif II; other site 297245005069 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 297245005070 DALR anticodon binding domain; Region: DALR_1; pfam05746 297245005071 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 297245005072 dimer interface [polypeptide binding]; other site 297245005073 motif 1; other site 297245005074 active site 297245005075 motif 2; other site 297245005076 motif 3; other site 297245005077 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 297245005078 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 297245005079 catalytic residues [active] 297245005080 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 297245005081 Part of AAA domain; Region: AAA_19; pfam13245 297245005082 Family description; Region: UvrD_C_2; pfam13538 297245005083 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 297245005084 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 297245005085 putative active site [active] 297245005086 dimerization interface [polypeptide binding]; other site 297245005087 putative tRNAtyr binding site [nucleotide binding]; other site 297245005088 VacJ like lipoprotein; Region: VacJ; cl01073 297245005089 glutathione synthetase; Provisional; Region: PRK05246 297245005090 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 297245005091 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 297245005092 Glutamate-cysteine ligase; Region: GshA; pfam08886 297245005093 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 297245005094 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 297245005095 EamA-like transporter family; Region: EamA; pfam00892 297245005096 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 297245005097 active site residue [active] 297245005098 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 297245005099 PglZ domain; Region: PglZ; pfam08665 297245005100 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 297245005101 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 297245005102 Sugar specificity; other site 297245005103 Pyrimidine base specificity; other site 297245005104 ATP-binding site [chemical binding]; other site 297245005105 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 297245005106 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 297245005107 NAD binding site [chemical binding]; other site 297245005108 homotetramer interface [polypeptide binding]; other site 297245005109 homodimer interface [polypeptide binding]; other site 297245005110 substrate binding site [chemical binding]; other site 297245005111 active site 297245005112 periplasmic folding chaperone; Provisional; Region: PRK10788 297245005113 SurA N-terminal domain; Region: SurA_N_3; cl07813 297245005114 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 297245005115 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 297245005116 IHF dimer interface [polypeptide binding]; other site 297245005117 IHF - DNA interface [nucleotide binding]; other site 297245005118 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 297245005119 Found in ATP-dependent protease La (LON); Region: LON; smart00464 297245005120 Found in ATP-dependent protease La (LON); Region: LON; smart00464 297245005121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245005122 Walker A motif; other site 297245005123 ATP binding site [chemical binding]; other site 297245005124 Walker B motif; other site 297245005125 arginine finger; other site 297245005126 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 297245005127 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 297245005128 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 297245005129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245005130 Walker A motif; other site 297245005131 ATP binding site [chemical binding]; other site 297245005132 Walker B motif; other site 297245005133 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 297245005134 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 297245005135 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 297245005136 oligomer interface [polypeptide binding]; other site 297245005137 active site residues [active] 297245005138 trigger factor; Provisional; Region: tig; PRK01490 297245005139 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 297245005140 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 297245005141 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 297245005142 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 297245005143 Int/Topo IB signature motif; other site 297245005144 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 297245005145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245005146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245005147 ABC transporter; Region: ABC_tran_2; pfam12848 297245005148 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245005149 ribonuclease III; Reviewed; Region: rnc; PRK00102 297245005150 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 297245005151 dimerization interface [polypeptide binding]; other site 297245005152 active site 297245005153 metal binding site [ion binding]; metal-binding site 297245005154 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 297245005155 dsRNA binding site [nucleotide binding]; other site 297245005156 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 297245005157 signal peptidase I; Provisional; Region: PRK10861 297245005158 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 297245005159 Catalytic site [active] 297245005160 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 297245005161 GTP-binding protein LepA; Provisional; Region: PRK05433 297245005162 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 297245005163 G1 box; other site 297245005164 putative GEF interaction site [polypeptide binding]; other site 297245005165 GTP/Mg2+ binding site [chemical binding]; other site 297245005166 Switch I region; other site 297245005167 G2 box; other site 297245005168 G3 box; other site 297245005169 Switch II region; other site 297245005170 G4 box; other site 297245005171 G5 box; other site 297245005172 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 297245005173 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 297245005174 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 297245005175 Transglycosylase SLT domain; Region: SLT_2; pfam13406 297245005176 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 297245005177 N-acetyl-D-glucosamine binding site [chemical binding]; other site 297245005178 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 297245005179 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 297245005180 GspL periplasmic domain; Region: GspL_C; cl14909 297245005181 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 297245005182 Sporulation related domain; Region: SPOR; cl10051 297245005183 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 297245005184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 297245005185 Zn2+ binding site [ion binding]; other site 297245005186 Mg2+ binding site [ion binding]; other site 297245005187 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 297245005188 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 297245005189 Trehalase; Region: Trehalase; cl17346 297245005190 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 297245005191 dimer interface [polypeptide binding]; other site 297245005192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 297245005193 active site 297245005194 metal binding site [ion binding]; metal-binding site 297245005195 glutathione binding site [chemical binding]; other site 297245005196 hypothetical protein; Provisional; Region: PRK05208 297245005197 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 297245005198 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 297245005199 acylphosphatase; Provisional; Region: PRK14451 297245005200 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 297245005201 PLD-like domain; Region: PLDc_2; pfam13091 297245005202 putative active site [active] 297245005203 catalytic site [active] 297245005204 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 297245005205 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 297245005206 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245005207 Leucine-rich repeats; other site 297245005208 Substrate binding site [chemical binding]; other site 297245005209 Leucine rich repeat; Region: LRR_8; pfam13855 297245005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245005211 D-galactonate transporter; Region: 2A0114; TIGR00893 297245005212 putative substrate translocation pore; other site 297245005213 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 297245005214 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 297245005215 putative ion selectivity filter; other site 297245005216 putative pore gating glutamate residue; other site 297245005217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 297245005218 SEC-C motif; Region: SEC-C; pfam02810 297245005219 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 297245005220 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 297245005221 TrkA-N domain; Region: TrkA_N; pfam02254 297245005222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245005223 Walker A motif; other site 297245005224 ATP binding site [chemical binding]; other site 297245005225 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 297245005226 Walker B motif; other site 297245005227 arginine finger; other site 297245005228 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 297245005229 Protein of unknown function DUF58; Region: DUF58; pfam01882 297245005230 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 297245005231 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 297245005232 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 297245005233 Uncharacterized conserved protein [Function unknown]; Region: COG2850 297245005234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245005235 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 297245005236 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 297245005237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 297245005238 nucleotide binding site [chemical binding]; other site 297245005239 Protein of unknown function, DUF462; Region: DUF462; pfam04315 297245005240 glutathionine S-transferase; Provisional; Region: PRK10542 297245005241 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 297245005242 C-terminal domain interface [polypeptide binding]; other site 297245005243 GSH binding site (G-site) [chemical binding]; other site 297245005244 dimer interface [polypeptide binding]; other site 297245005245 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 297245005246 N-terminal domain interface [polypeptide binding]; other site 297245005247 dimer interface [polypeptide binding]; other site 297245005248 substrate binding pocket (H-site) [chemical binding]; other site 297245005249 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 297245005250 Beta-lactamase; Region: Beta-lactamase; pfam00144 297245005251 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 297245005252 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 297245005253 HIGH motif; other site 297245005254 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 297245005255 active site 297245005256 KMSKS motif; other site 297245005257 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 297245005258 HAMP domain; Region: HAMP; pfam00672 297245005259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245005260 dimer interface [polypeptide binding]; other site 297245005261 phosphorylation site [posttranslational modification] 297245005262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245005263 ATP binding site [chemical binding]; other site 297245005264 Mg2+ binding site [ion binding]; other site 297245005265 G-X-G motif; other site 297245005266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245005267 active site 297245005268 phosphorylation site [posttranslational modification] 297245005269 intermolecular recognition site; other site 297245005270 dimerization interface [polypeptide binding]; other site 297245005271 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 297245005272 putative binding surface; other site 297245005273 active site 297245005274 6-phosphofructokinase; Provisional; Region: PRK14072 297245005275 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 297245005276 active site 297245005277 ADP/pyrophosphate binding site [chemical binding]; other site 297245005278 dimerization interface [polypeptide binding]; other site 297245005279 allosteric effector site; other site 297245005280 fructose-1,6-bisphosphate binding site; other site 297245005281 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 297245005282 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 297245005283 Pilin (bacterial filament); Region: Pilin; pfam00114 297245005284 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 297245005285 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 297245005286 Pilin (bacterial filament); Region: Pilin; pfam00114 297245005287 BolA-like protein; Region: BolA; cl00386 297245005288 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 297245005289 Calcium-activated chloride channel; Region: Anoctamin; pfam04547 297245005290 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 297245005291 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 297245005292 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 297245005293 Ligand binding site; other site 297245005294 oligomer interface; other site 297245005295 Trm112p-like protein; Region: Trm112p; cl01066 297245005296 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 297245005297 Glycoprotease family; Region: Peptidase_M22; pfam00814 297245005298 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 297245005299 DEAD/DEAH box helicase; Region: DEAD; pfam00270 297245005300 ATP binding site [chemical binding]; other site 297245005301 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 297245005302 Ferredoxin [Energy production and conversion]; Region: COG1146 297245005303 4Fe-4S binding domain; Region: Fer4; cl02805 297245005304 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 297245005305 ATP-dependent protease La; Region: lon; TIGR00763 297245005306 PilZ domain; Region: PilZ; pfam07238 297245005307 oxidative damage protection protein; Provisional; Region: PRK05408 297245005308 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 297245005309 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245005310 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 297245005311 Similar to transposase;hypothetical protein 297245005312 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 297245005313 active site clefts [active] 297245005314 zinc binding site [ion binding]; other site 297245005315 dimer interface [polypeptide binding]; other site 297245005316 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 297245005317 active site 297245005318 substrate binding site [chemical binding]; other site 297245005319 ATP binding site [chemical binding]; other site 297245005320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 297245005321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245005322 non-specific DNA binding site [nucleotide binding]; other site 297245005323 salt bridge; other site 297245005324 sequence-specific DNA binding site [nucleotide binding]; other site 297245005325 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 297245005326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245005327 S-adenosylmethionine binding site [chemical binding]; other site 297245005328 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 297245005329 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 297245005330 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 297245005331 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 297245005332 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 297245005333 active site 297245005334 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 297245005335 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 297245005336 acyl-activating enzyme (AAE) consensus motif; other site 297245005337 AMP binding site [chemical binding]; other site 297245005338 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 297245005339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 297245005340 active site 297245005341 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 297245005342 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 297245005343 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 297245005344 Phosphopantetheine attachment site; Region: PP-binding; cl09936 297245005345 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 297245005346 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 297245005347 active site 297245005348 nucleophile elbow; other site 297245005349 Patatin phospholipase; Region: DUF3734; pfam12536 297245005350 Toprim domain; Region: Toprim_3; pfam13362 297245005351 active site 297245005352 metal binding site [ion binding]; metal-binding site 297245005353 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 297245005354 Similar to N-terminal part of transcriptional regulator;hypothetical protein 297245005355 Similar to C-terminal part of unknown protein;hypothetical protein 297245005356 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171 297245005357 active site/putative ARF binding site [active] 297245005358 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 297245005359 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 297245005360 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 297245005361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 297245005362 active site 297245005363 metal binding site [ion binding]; metal-binding site 297245005364 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 297245005365 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 297245005366 active site 297245005367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 297245005368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 297245005369 DNA binding residues [nucleotide binding] 297245005370 Fic/DOC family; Region: Fic; cl00960 297245005371 Homeodomain-like domain; Region: HTH_23; pfam13384 297245005372 Winged helix-turn helix; Region: HTH_29; pfam13551 297245005373 Winged helix-turn helix; Region: HTH_33; pfam13592 297245005374 DDE superfamily endonuclease; Region: DDE_3; pfam13358 297245005375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 297245005376 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 297245005377 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 297245005378 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 297245005379 active site 297245005380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 297245005381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 297245005382 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 297245005383 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245005384 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 297245005385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 297245005386 active site 297245005387 AMP binding site [chemical binding]; other site 297245005388 acyl-activating enzyme (AAE) consensus motif; other site 297245005389 Transcriptional regulators [Transcription]; Region: GntR; COG1802 297245005390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 297245005391 DNA-binding site [nucleotide binding]; DNA binding site 297245005392 FCD domain; Region: FCD; pfam07729 297245005393 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 297245005394 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245005395 active site 297245005396 nucleotide binding site [chemical binding]; other site 297245005397 HIGH motif; other site 297245005398 KMSKS motif; other site 297245005399 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 297245005400 Cupin domain; Region: Cupin_2; cl17218 297245005401 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 297245005402 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 297245005403 C-terminal domain interface [polypeptide binding]; other site 297245005404 GSH binding site (G-site) [chemical binding]; other site 297245005405 dimer interface [polypeptide binding]; other site 297245005406 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 297245005407 N-terminal domain interface [polypeptide binding]; other site 297245005408 putative dimer interface [polypeptide binding]; other site 297245005409 active site 297245005410 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 297245005411 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245005412 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 297245005413 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 297245005414 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 297245005415 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 297245005416 intracellular protease, PfpI family; Region: PfpI; TIGR01382 297245005417 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 297245005418 conserved cys residue [active] 297245005419 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 297245005420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 297245005421 TPR repeat; Region: TPR_11; pfam13414 297245005422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245005423 binding surface 297245005424 TPR motif; other site 297245005425 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 297245005426 guanine deaminase; Provisional; Region: PRK09228 297245005427 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 297245005428 active site 297245005429 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 297245005430 Toprim domain; Region: Toprim_3; pfam13362 297245005431 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 297245005432 catalytic core [active] 297245005433 RibD C-terminal domain; Region: RibD_C; cl17279 297245005434 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 297245005435 MAPEG family; Region: MAPEG; cl09190 297245005436 Homeodomain-like domain; Region: HTH_23; pfam13384 297245005437 Winged helix-turn helix; Region: HTH_29; pfam13551 297245005438 Winged helix-turn helix; Region: HTH_33; pfam13592 297245005439 DDE superfamily endonuclease; Region: DDE_3; pfam13358 297245005440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 297245005441 YhhN-like protein; Region: YhhN; pfam07947 297245005442 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 297245005443 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 297245005444 NodB motif; other site 297245005445 putative active site [active] 297245005446 putative catalytic site [active] 297245005447 putative Zn binding site [ion binding]; other site 297245005448 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 297245005449 MltA specific insert domain; Region: MltA; pfam03562 297245005450 3D domain; Region: 3D; pfam06725 297245005451 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 297245005452 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 297245005453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 297245005454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245005455 homodimer interface [polypeptide binding]; other site 297245005456 catalytic residue [active] 297245005457 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 297245005458 aromatic arch; other site 297245005459 DCoH dimer interaction site [polypeptide binding]; other site 297245005460 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 297245005461 DCoH tetramer interaction site [polypeptide binding]; other site 297245005462 substrate binding site [chemical binding]; other site 297245005463 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 297245005464 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 297245005465 Protein export membrane protein; Region: SecD_SecF; pfam02355 297245005466 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 297245005467 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 297245005468 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 297245005469 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 297245005470 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 297245005471 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 297245005472 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 297245005473 ABC transporter ATPase component; Reviewed; Region: PRK11147 297245005474 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245005475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245005476 ABC transporter; Region: ABC_tran_2; pfam12848 297245005477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 297245005478 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 297245005479 catalytic motif [active] 297245005480 Catalytic residue [active] 297245005481 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 297245005482 homotrimer interaction site [polypeptide binding]; other site 297245005483 putative active site [active] 297245005484 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 297245005485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 297245005486 Zn2+ binding site [ion binding]; other site 297245005487 Mg2+ binding site [ion binding]; other site 297245005488 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 297245005489 synthetase active site [active] 297245005490 NTP binding site [chemical binding]; other site 297245005491 metal binding site [ion binding]; metal-binding site 297245005492 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 297245005493 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 297245005494 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 297245005495 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 297245005496 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 297245005497 catalytic site [active] 297245005498 G-X2-G-X-G-K; other site 297245005499 hypothetical protein; Provisional; Region: PRK11820 297245005500 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 297245005501 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 297245005502 ribonuclease PH; Reviewed; Region: rph; PRK00173 297245005503 Ribonuclease PH; Region: RNase_PH_bact; cd11362 297245005504 hexamer interface [polypeptide binding]; other site 297245005505 active site 297245005506 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 297245005507 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 297245005508 Walker A motif; other site 297245005509 ATP binding site [chemical binding]; other site 297245005510 Walker B motif; other site 297245005511 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 297245005512 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 297245005513 catalytic residue [active] 297245005514 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 297245005515 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 297245005516 YGGT family; Region: YGGT; pfam02325 297245005517 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 297245005518 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 297245005519 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 297245005520 active site 297245005521 catalytic residues [active] 297245005522 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 297245005523 Helix-turn-helix domain; Region: HTH_18; pfam12833 297245005524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 297245005525 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 297245005526 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 297245005527 homotetramer interface [polypeptide binding]; other site 297245005528 ligand binding site [chemical binding]; other site 297245005529 catalytic site [active] 297245005530 NAD binding site [chemical binding]; other site 297245005531 S-adenosylmethionine synthetase; Validated; Region: PRK05250 297245005532 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 297245005533 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 297245005534 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 297245005535 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 297245005536 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 297245005537 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 297245005538 catalytic site [active] 297245005539 subunit interface [polypeptide binding]; other site 297245005540 chaperone protein DnaJ; Provisional; Region: PRK10767 297245005541 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 297245005542 HSP70 interaction site [polypeptide binding]; other site 297245005543 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 297245005544 substrate binding site [polypeptide binding]; other site 297245005545 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 297245005546 Zn binding sites [ion binding]; other site 297245005547 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 297245005548 dimer interface [polypeptide binding]; other site 297245005549 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 297245005550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 297245005551 nucleotide binding site [chemical binding]; other site 297245005552 GrpE; Region: GrpE; pfam01025 297245005553 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 297245005554 dimer interface [polypeptide binding]; other site 297245005555 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 297245005556 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 297245005557 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 297245005558 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 297245005559 substrate binding site [chemical binding]; other site 297245005560 active site 297245005561 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 297245005562 homooctamer interface [polypeptide binding]; other site 297245005563 active site 297245005564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 297245005565 Sporulation related domain; Region: SPOR; pfam05036 297245005566 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 297245005567 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 297245005568 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245005569 active site 297245005570 HIGH motif; other site 297245005571 nucleotide binding site [chemical binding]; other site 297245005572 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 297245005573 KMSK motif region; other site 297245005574 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 297245005575 tRNA binding surface [nucleotide binding]; other site 297245005576 anticodon binding site; other site 297245005577 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 297245005578 Domain of unknown function DUF20; Region: UPF0118; pfam01594 297245005579 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 297245005580 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 297245005581 generic binding surface II; other site 297245005582 ssDNA binding site; other site 297245005583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245005584 ATP binding site [chemical binding]; other site 297245005585 putative Mg++ binding site [ion binding]; other site 297245005586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245005587 nucleotide binding region [chemical binding]; other site 297245005588 ATP-binding site [chemical binding]; other site 297245005589 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 297245005590 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 297245005591 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 297245005592 Maf-like protein; Region: Maf; pfam02545 297245005593 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 297245005594 active site 297245005595 dimer interface [polypeptide binding]; other site 297245005596 enolase; Provisional; Region: eno; PRK00077 297245005597 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 297245005598 dimer interface [polypeptide binding]; other site 297245005599 metal binding site [ion binding]; metal-binding site 297245005600 substrate binding pocket [chemical binding]; other site 297245005601 Septum formation initiator; Region: DivIC; cl17659 297245005602 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 297245005603 mevalonate kinase; Region: mevalon_kin; TIGR00549 297245005604 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 297245005605 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 297245005606 diphosphomevalonate decarboxylase; Region: PLN02407 297245005607 diphosphomevalonate decarboxylase; Region: PLN02407 297245005608 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 297245005609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245005610 FeS/SAM binding site; other site 297245005611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245005612 binding surface 297245005613 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 297245005614 TPR motif; other site 297245005615 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 297245005616 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245005617 ligand binding site [chemical binding]; other site 297245005618 Protein of unknown function (DUF330); Region: DUF330; cl01135 297245005619 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 297245005620 mce related protein; Region: MCE; pfam02470 297245005621 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 297245005622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245005623 Walker A/P-loop; other site 297245005624 ATP binding site [chemical binding]; other site 297245005625 Q-loop/lid; other site 297245005626 ABC transporter signature motif; other site 297245005627 Walker B; other site 297245005628 D-loop; other site 297245005629 H-loop/switch region; other site 297245005630 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 297245005631 Permease; Region: Permease; pfam02405 297245005632 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 297245005633 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 297245005634 active site 297245005635 ATP binding site [chemical binding]; other site 297245005636 substrate binding site [chemical binding]; other site 297245005637 activation loop (A-loop); other site 297245005638 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 297245005639 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 297245005640 homotetramer interface [polypeptide binding]; other site 297245005641 FMN binding site [chemical binding]; other site 297245005642 homodimer contacts [polypeptide binding]; other site 297245005643 putative active site [active] 297245005644 putative substrate binding site [chemical binding]; other site 297245005645 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 297245005646 homodimer interface [polypeptide binding]; other site 297245005647 catalytic residues [active] 297245005648 NAD binding site [chemical binding]; other site 297245005649 substrate binding pocket [chemical binding]; other site 297245005650 flexible flap; other site 297245005651 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245005652 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 297245005653 Winged helix-turn helix; Region: HTH_29; pfam13551 297245005654 Helix-turn-helix domain; Region: HTH_28; pfam13518 297245005655 Integrase core domain; Region: rve; pfam00665 297245005656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 297245005657 Integrase core domain; Region: rve_3; pfam13683 297245005658 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 297245005659 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 297245005660 catalytic Zn binding site [ion binding]; other site 297245005661 structural Zn binding site [ion binding]; other site 297245005662 NAD(P) binding site [chemical binding]; other site 297245005663 FOG: CBS domain [General function prediction only]; Region: COG0517 297245005664 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619 297245005665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 297245005666 helix-hairpin-helix signature motif; other site 297245005667 active site 297245005668 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 297245005669 DNA-binding site [nucleotide binding]; DNA binding site 297245005670 RNA-binding motif; other site 297245005671 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 297245005672 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 297245005673 ATP binding site [chemical binding]; other site 297245005674 Mg++ binding site [ion binding]; other site 297245005675 motif III; other site 297245005676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245005677 nucleotide binding region [chemical binding]; other site 297245005678 ATP-binding site [chemical binding]; other site 297245005679 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 297245005680 putative RNA binding site [nucleotide binding]; other site 297245005681 Cation efflux family; Region: Cation_efflux; cl00316 297245005682 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 297245005683 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 297245005684 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005686 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005687 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005688 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 297245005689 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005690 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245005693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245005694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 297245005695 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005696 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005697 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005698 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005699 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005700 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 297245005701 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005702 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005703 Dot/Icm substrate protein; Region: SidE; pfam12252 297245005704 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 297245005705 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 297245005706 ligand binding site [chemical binding]; other site 297245005707 K+ potassium transporter; Region: K_trans; pfam02705 297245005708 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005709 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005710 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 297245005711 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245005712 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 297245005713 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005714 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005715 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005716 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005717 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005718 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005719 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005720 PAS domain S-box; Region: sensory_box; TIGR00229 297245005721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245005722 putative active site [active] 297245005723 heme pocket [chemical binding]; other site 297245005724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245005725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245005726 metal binding site [ion binding]; metal-binding site 297245005727 active site 297245005728 I-site; other site 297245005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245005730 metabolite-proton symporter; Region: 2A0106; TIGR00883 297245005731 putative substrate translocation pore; other site 297245005732 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 297245005733 Protein export membrane protein; Region: SecD_SecF; cl14618 297245005734 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 297245005735 carboxyltransferase (CT) interaction site; other site 297245005736 biotinylation site [posttranslational modification]; other site 297245005737 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245005738 Outer membrane efflux protein; Region: OEP; pfam02321 297245005739 Outer membrane efflux protein; Region: OEP; pfam02321 297245005740 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 297245005741 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 297245005742 activation loop (A-loop); other site 297245005743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245005744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245005745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 297245005746 dimerization interface [polypeptide binding]; other site 297245005747 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 297245005748 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 297245005749 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 297245005750 Predicted transcriptional regulators [Transcription]; Region: COG1733 297245005751 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 297245005752 classical (c) SDRs; Region: SDR_c; cd05233 297245005753 NAD(P) binding site [chemical binding]; other site 297245005754 active site 297245005755 F-box-like; Region: F-box-like; pfam12937 297245005756 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 297245005757 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005758 Response regulator receiver domain; Region: Response_reg; pfam00072 297245005759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245005760 active site 297245005761 phosphorylation site [posttranslational modification] 297245005762 intermolecular recognition site; other site 297245005763 dimerization interface [polypeptide binding]; other site 297245005764 PAS domain; Region: PAS; smart00091 297245005765 PAS fold; Region: PAS_4; pfam08448 297245005766 putative active site [active] 297245005767 heme pocket [chemical binding]; other site 297245005768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 297245005769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245005770 dimer interface [polypeptide binding]; other site 297245005771 phosphorylation site [posttranslational modification] 297245005772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245005773 ATP binding site [chemical binding]; other site 297245005774 Mg2+ binding site [ion binding]; other site 297245005775 G-X-G motif; other site 297245005776 Response regulator receiver domain; Region: Response_reg; pfam00072 297245005777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245005778 active site 297245005779 phosphorylation site [posttranslational modification] 297245005780 intermolecular recognition site; other site 297245005781 dimerization interface [polypeptide binding]; other site 297245005782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245005783 dimer interface [polypeptide binding]; other site 297245005784 phosphorylation site [posttranslational modification] 297245005785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245005786 ATP binding site [chemical binding]; other site 297245005787 Mg2+ binding site [ion binding]; other site 297245005788 G-X-G motif; other site 297245005789 truncated protein, N-terminal part missing;hypothetical protein 297245005790 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 297245005791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 297245005792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 297245005793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245005794 Walker A/P-loop; other site 297245005795 ATP binding site [chemical binding]; other site 297245005796 Q-loop/lid; other site 297245005797 ABC transporter signature motif; other site 297245005798 Walker B; other site 297245005799 D-loop; other site 297245005800 H-loop/switch region; other site 297245005801 Dot/Icm substrate protein; Region: SidE; pfam12252 297245005802 Dot/Icm substrate protein; Region: SidE; pfam12252 297245005803 Dot/Icm substrate protein; Region: SidE; pfam12252 297245005804 Dot/Icm substrate protein; Region: SidE; pfam12252 297245005805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245005806 S-adenosylmethionine binding site [chemical binding]; other site 297245005807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245005809 S-adenosylmethionine binding site [chemical binding]; other site 297245005810 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 297245005811 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 297245005812 Predicted transcriptional regulator [Transcription]; Region: COG2378 297245005813 HTH domain; Region: HTH_11; pfam08279 297245005814 WYL domain; Region: WYL; pfam13280 297245005815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245005816 Coenzyme A binding pocket [chemical binding]; other site 297245005817 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 297245005818 putative dimer interface [polypeptide binding]; other site 297245005819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 297245005820 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 297245005821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 297245005822 DNA binding residues [nucleotide binding] 297245005823 dimerization interface [polypeptide binding]; other site 297245005824 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 297245005825 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 297245005826 active site 297245005827 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 297245005828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245005829 catalytic residue [active] 297245005830 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 297245005831 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245005832 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245005833 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 297245005834 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 297245005835 putative binding surface; other site 297245005836 active site 297245005837 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 297245005838 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 297245005839 acyl-activating enzyme (AAE) consensus motif; other site 297245005840 AMP binding site [chemical binding]; other site 297245005841 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 297245005842 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 297245005843 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 297245005844 active site 297245005845 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 297245005846 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 297245005847 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 297245005848 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 297245005849 putative NADP binding site [chemical binding]; other site 297245005850 active site 297245005851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 297245005852 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 297245005853 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 297245005854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245005855 dimer interface [polypeptide binding]; other site 297245005856 phosphorylation site [posttranslational modification] 297245005857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245005858 ATP binding site [chemical binding]; other site 297245005859 Mg2+ binding site [ion binding]; other site 297245005860 G-X-G motif; other site 297245005861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 297245005862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245005863 active site 297245005864 phosphorylation site [posttranslational modification] 297245005865 intermolecular recognition site; other site 297245005866 dimerization interface [polypeptide binding]; other site 297245005867 Response regulator receiver domain; Region: Response_reg; pfam00072 297245005868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245005869 active site 297245005870 phosphorylation site [posttranslational modification] 297245005871 intermolecular recognition site; other site 297245005872 dimerization interface [polypeptide binding]; other site 297245005873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245005874 Methyltransferase domain; Region: Methyltransf_31; pfam13847 297245005875 S-adenosylmethionine binding site [chemical binding]; other site 297245005876 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 297245005877 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 297245005878 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 297245005879 active site 297245005880 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 297245005881 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 297245005882 active site 297245005883 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 297245005884 KR domain; Region: KR; pfam08659 297245005885 NADP binding site [chemical binding]; other site 297245005886 active site 297245005887 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 297245005888 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 297245005889 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 297245005890 active site 297245005891 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 297245005892 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 297245005893 KR domain; Region: KR; pfam08659 297245005894 putative NADP binding site [chemical binding]; other site 297245005895 active site 297245005896 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 297245005897 Condensation domain; Region: Condensation; pfam00668 297245005898 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 297245005899 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245005900 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245005901 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 297245005902 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 297245005903 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 297245005904 putative dimer interface [polypeptide binding]; other site 297245005905 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 297245005906 Sulfate transporter family; Region: Sulfate_transp; pfam00916 297245005907 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 297245005908 active site clefts [active] 297245005909 zinc binding site [ion binding]; other site 297245005910 dimer interface [polypeptide binding]; other site 297245005911 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 297245005912 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 297245005913 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 297245005914 SnoaL-like domain; Region: SnoaL_3; pfam13474 297245005915 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 297245005916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245005917 putative substrate translocation pore; other site 297245005918 POT family; Region: PTR2; cl17359 297245005919 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 297245005920 hypothetical protein; Reviewed; Region: PRK09588 297245005921 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 297245005922 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 297245005923 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 297245005924 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 297245005925 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 297245005926 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 297245005927 putative NAD(P) binding site [chemical binding]; other site 297245005928 dimer interface [polypeptide binding]; other site 297245005929 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 297245005930 substrate binding site [chemical binding]; other site 297245005931 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 297245005932 YARHG domain; Region: YARHG; pfam13308 297245005933 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 297245005934 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 297245005935 active site 297245005936 metal binding site [ion binding]; metal-binding site 297245005937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245005938 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 297245005939 NAD(P) binding site [chemical binding]; other site 297245005940 active site 297245005941 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245005942 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245005943 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 297245005944 active site 297245005945 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 297245005946 iron-sulfur cluster [ion binding]; other site 297245005947 [2Fe-2S] cluster binding site [ion binding]; other site 297245005948 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 297245005949 hydrophobic ligand binding site; other site 297245005950 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 297245005951 putative trimer interface [polypeptide binding]; other site 297245005952 putative CoA binding site [chemical binding]; other site 297245005953 Sel1 repeat; Region: Sel1; pfam08238 297245005954 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245005955 Sel1-like repeats; Region: SEL1; smart00671 297245005956 Sel1 repeat; Region: Sel1; pfam08238 297245005957 Sel1-like repeats; Region: SEL1; smart00671 297245005958 Sel1-like repeats; Region: SEL1; smart00671 297245005959 Sel1-like repeats; Region: SEL1; smart00671 297245005960 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245005961 GH3 auxin-responsive promoter; Region: GH3; pfam03321 297245005962 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 297245005963 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 297245005964 active site 297245005965 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 297245005966 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 297245005967 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 297245005968 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 297245005969 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 297245005970 active site 297245005971 acyl-CoA synthetase; Validated; Region: PRK05850 297245005972 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 297245005973 acyl-activating enzyme (AAE) consensus motif; other site 297245005974 active site 297245005975 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 297245005976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 297245005977 acyl-activating enzyme (AAE) consensus motif; other site 297245005978 AMP binding site [chemical binding]; other site 297245005979 active site 297245005980 CoA binding site [chemical binding]; other site 297245005981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 297245005982 classical (c) SDRs; Region: SDR_c; cd05233 297245005983 NAD(P) binding site [chemical binding]; other site 297245005984 active site 297245005985 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 297245005986 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 297245005987 dimer interface [polypeptide binding]; other site 297245005988 active site 297245005989 CoA binding pocket [chemical binding]; other site 297245005990 Phosphopantetheine attachment site; Region: PP-binding; cl09936 297245005991 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 297245005992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245005993 putative substrate translocation pore; other site 297245005994 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 297245005995 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 297245005996 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 297245005997 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 297245005998 Binuclear center (active site) [active] 297245005999 K-pathway; other site 297245006000 Putative proton exit pathway; other site 297245006001 Putative water exit pathway; other site 297245006002 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 297245006003 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 297245006004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245006005 Walker A/P-loop; other site 297245006006 ATP binding site [chemical binding]; other site 297245006007 Q-loop/lid; other site 297245006008 ABC transporter signature motif; other site 297245006009 Walker B; other site 297245006010 D-loop; other site 297245006011 H-loop/switch region; other site 297245006012 MAPEG family; Region: MAPEG; cl09190 297245006013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245006014 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 297245006015 hypothetical protein; Validated; Region: PRK07198 297245006016 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 297245006017 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 297245006018 dimerization interface [polypeptide binding]; other site 297245006019 active site 297245006020 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 297245006021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245006022 active site 297245006023 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 297245006024 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 297245006025 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 297245006026 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 297245006027 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 297245006028 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 297245006029 catalytic triad [active] 297245006030 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 297245006031 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 297245006032 putative active site [active] 297245006033 metal binding site [ion binding]; metal-binding site 297245006034 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 297245006035 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 297245006036 NAD(P) binding site [chemical binding]; other site 297245006037 catalytic residues [active] 297245006038 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 297245006039 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 297245006040 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 297245006041 hypothetical protein; Provisional; Region: PRK05409 297245006042 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 297245006043 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 297245006044 Beta-Casp domain; Region: Beta-Casp; pfam10996 297245006045 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 297245006046 BON domain; Region: BON; pfam04972 297245006047 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 297245006048 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 297245006049 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 297245006050 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 297245006051 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 297245006052 dimer interaction site [polypeptide binding]; other site 297245006053 substrate-binding tunnel; other site 297245006054 active site 297245006055 catalytic site [active] 297245006056 substrate binding site [chemical binding]; other site 297245006057 phosphate acetyltransferase; Provisional; Region: PRK11890 297245006058 propionate/acetate kinase; Provisional; Region: PRK12379 297245006059 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 297245006060 nucleotide binding site [chemical binding]; other site 297245006061 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 297245006062 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 297245006063 HSP70 interaction site [polypeptide binding]; other site 297245006064 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 297245006065 substrate binding site [polypeptide binding]; other site 297245006066 dimer interface [polypeptide binding]; other site 297245006067 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 297245006068 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 297245006069 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 297245006070 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 297245006071 putative acyl-acceptor binding pocket; other site 297245006072 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 297245006073 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 297245006074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 297245006075 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 297245006076 active site 297245006077 probable DNA repair protein; Region: TIGR03623 297245006078 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 297245006079 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 297245006080 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 297245006081 putative NAD(P) binding site [chemical binding]; other site 297245006082 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 297245006083 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 297245006084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 297245006085 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 297245006086 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 297245006087 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 297245006088 putative active site [active] 297245006089 catalytic site [active] 297245006090 putative metal binding site [ion binding]; other site 297245006091 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 297245006092 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 297245006093 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 297245006094 NAD binding site [chemical binding]; other site 297245006095 Phe binding site; other site 297245006096 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 297245006097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006098 S-adenosylmethionine binding site [chemical binding]; other site 297245006099 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 297245006100 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 297245006101 dimer interface [polypeptide binding]; other site 297245006102 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 297245006103 active site 297245006104 Fe binding site [ion binding]; other site 297245006105 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 297245006106 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 297245006107 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 297245006108 maleylacetoacetate isomerase; Region: maiA; TIGR01262 297245006109 C-terminal domain interface [polypeptide binding]; other site 297245006110 GSH binding site (G-site) [chemical binding]; other site 297245006111 putative dimer interface [polypeptide binding]; other site 297245006112 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 297245006113 dimer interface [polypeptide binding]; other site 297245006114 N-terminal domain interface [polypeptide binding]; other site 297245006115 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 297245006116 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 297245006117 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 297245006118 putative dimer interface [polypeptide binding]; other site 297245006119 putative anticodon binding site; other site 297245006120 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 297245006121 homodimer interface [polypeptide binding]; other site 297245006122 motif 1; other site 297245006123 motif 2; other site 297245006124 active site 297245006125 motif 3; other site 297245006126 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 297245006127 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 297245006128 Walker A/P-loop; other site 297245006129 ATP binding site [chemical binding]; other site 297245006130 Q-loop/lid; other site 297245006131 ABC transporter signature motif; other site 297245006132 Walker B; other site 297245006133 D-loop; other site 297245006134 H-loop/switch region; other site 297245006135 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 297245006136 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 297245006137 FtsX-like permease family; Region: FtsX; pfam02687 297245006138 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 297245006139 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 297245006140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245006141 motif II; other site 297245006142 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 297245006143 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 297245006144 RNA binding surface [nucleotide binding]; other site 297245006145 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 297245006146 active site 297245006147 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 297245006148 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 297245006149 homodimer interface [polypeptide binding]; other site 297245006150 oligonucleotide binding site [chemical binding]; other site 297245006151 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 297245006152 ATP-dependent helicase HepA; Validated; Region: PRK04914 297245006153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245006154 ATP binding site [chemical binding]; other site 297245006155 putative Mg++ binding site [ion binding]; other site 297245006156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245006157 nucleotide binding region [chemical binding]; other site 297245006158 ATP-binding site [chemical binding]; other site 297245006159 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245006160 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245006161 Smr domain; Region: Smr; pfam01713 297245006162 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 297245006163 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 297245006164 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 297245006165 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 297245006166 Tetramer interface [polypeptide binding]; other site 297245006167 active site 297245006168 FMN-binding site [chemical binding]; other site 297245006169 HemK family putative methylases; Region: hemK_fam; TIGR00536 297245006170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006171 S-adenosylmethionine binding site [chemical binding]; other site 297245006172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 297245006173 Smr domain; Region: Smr; pfam01713 297245006174 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 297245006175 active site residue [active] 297245006176 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 297245006177 GSH binding site [chemical binding]; other site 297245006178 catalytic residues [active] 297245006179 preprotein translocase subunit SecB; Validated; Region: PRK05751 297245006180 SecA binding site; other site 297245006181 Preprotein binding site; other site 297245006182 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 297245006183 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 297245006184 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 297245006185 glutamate racemase; Provisional; Region: PRK00865 297245006186 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 297245006187 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 297245006188 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 297245006189 dihydrodipicolinate synthase; Region: dapA; TIGR00674 297245006190 dimer interface [polypeptide binding]; other site 297245006191 active site 297245006192 catalytic residue [active] 297245006193 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 297245006194 classical (c) SDRs; Region: SDR_c; cd05233 297245006195 NAD(P) binding site [chemical binding]; other site 297245006196 active site 297245006197 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 297245006198 nucleophile elbow; other site 297245006199 Patatin phospholipase; Region: DUF3734; pfam12536 297245006200 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 297245006201 flagellar motor protein MotA; Validated; Region: PRK09110 297245006202 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 297245006203 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 297245006204 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245006205 ligand binding site [chemical binding]; other site 297245006206 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 297245006207 serine transporter; Region: stp; TIGR00814 297245006208 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 297245006209 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245006210 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 297245006211 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 297245006212 ATP binding site [chemical binding]; other site 297245006213 Walker B motif; other site 297245006214 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 297245006215 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 297245006216 DNA repair protein RadA; Provisional; Region: PRK11823 297245006217 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 297245006218 Walker A motif; other site 297245006219 ATP binding site [chemical binding]; other site 297245006220 Walker B motif; other site 297245006221 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 297245006222 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 297245006223 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 297245006224 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 297245006225 substrate binding pocket [chemical binding]; other site 297245006226 chain length determination region; other site 297245006227 substrate-Mg2+ binding site; other site 297245006228 catalytic residues [active] 297245006229 aspartate-rich region 1; other site 297245006230 active site lid residues [active] 297245006231 aspartate-rich region 2; other site 297245006232 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 297245006233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006234 S-adenosylmethionine binding site [chemical binding]; other site 297245006235 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 297245006236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 297245006237 active site 297245006238 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 297245006239 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 297245006240 active site 297245006241 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 297245006242 protein binding site [polypeptide binding]; other site 297245006243 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 297245006244 putative substrate binding region [chemical binding]; other site 297245006245 GrpE; Region: GrpE; pfam01025 297245006246 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 297245006247 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 297245006248 tRNA; other site 297245006249 putative tRNA binding site [nucleotide binding]; other site 297245006250 putative NADP binding site [chemical binding]; other site 297245006251 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 297245006252 peptide chain release factor 1; Validated; Region: prfA; PRK00591 297245006253 This domain is found in peptide chain release factors; Region: PCRF; smart00937 297245006254 RF-1 domain; Region: RF-1; pfam00472 297245006255 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 297245006256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006257 S-adenosylmethionine binding site [chemical binding]; other site 297245006258 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 297245006259 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 297245006260 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 297245006261 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 297245006262 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 297245006263 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 297245006264 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 297245006265 putative metal binding site [ion binding]; other site 297245006266 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 297245006267 HSP70 interaction site [polypeptide binding]; other site 297245006268 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 297245006269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 297245006270 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 297245006271 active site 297245006272 catalytic triad [active] 297245006273 oxyanion hole [active] 297245006274 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 297245006275 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 297245006276 ATP binding site [chemical binding]; other site 297245006277 Mg++ binding site [ion binding]; other site 297245006278 motif III; other site 297245006279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 297245006280 nucleotide binding region [chemical binding]; other site 297245006281 ATP-binding site [chemical binding]; other site 297245006282 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 297245006283 putative RNA binding site [nucleotide binding]; other site 297245006284 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 297245006285 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 297245006286 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 297245006287 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 297245006288 active site 297245006289 FMN binding site [chemical binding]; other site 297245006290 2,4-decadienoyl-CoA binding site; other site 297245006291 catalytic residue [active] 297245006292 4Fe-4S cluster binding site [ion binding]; other site 297245006293 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 297245006294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 297245006295 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 297245006296 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 297245006297 E-class dimer interface [polypeptide binding]; other site 297245006298 P-class dimer interface [polypeptide binding]; other site 297245006299 active site 297245006300 Cu2+ binding site [ion binding]; other site 297245006301 Zn2+ binding site [ion binding]; other site 297245006302 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 297245006303 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 297245006304 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 297245006305 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 297245006306 dimer interface [polypeptide binding]; other site 297245006307 decamer (pentamer of dimers) interface [polypeptide binding]; other site 297245006308 catalytic triad [active] 297245006309 peroxidatic and resolving cysteines [active] 297245006310 malate dehydrogenase; Provisional; Region: PRK05442 297245006311 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 297245006312 NAD(P) binding site [chemical binding]; other site 297245006313 dimer interface [polypeptide binding]; other site 297245006314 malate binding site [chemical binding]; other site 297245006315 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 297245006316 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 297245006317 dimer interface [polypeptide binding]; other site 297245006318 ADP-ribose binding site [chemical binding]; other site 297245006319 active site 297245006320 nudix motif; other site 297245006321 metal binding site [ion binding]; metal-binding site 297245006322 HemN family oxidoreductase; Provisional; Region: PRK05660 297245006323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 297245006324 FeS/SAM binding site; other site 297245006325 HemN C-terminal domain; Region: HemN_C; pfam06969 297245006326 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 297245006327 Amidase; Region: Amidase; pfam01425 297245006328 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 297245006329 UGMP family protein; Validated; Region: PRK09604 297245006330 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 297245006331 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 297245006332 Yqey-like protein; Region: YqeY; pfam09424 297245006333 DNA primase; Validated; Region: dnaG; PRK05667 297245006334 CHC2 zinc finger; Region: zf-CHC2; pfam01807 297245006335 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 297245006336 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 297245006337 active site 297245006338 metal binding site [ion binding]; metal-binding site 297245006339 interdomain interaction site; other site 297245006340 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 297245006341 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 297245006342 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 297245006343 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 297245006344 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 297245006345 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 297245006346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 297245006347 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 297245006348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 297245006349 DNA binding residues [nucleotide binding] 297245006350 Similar to C-terminal part of transposase;hypothetical protein 297245006351 Similar to N-terminal part of transposase;hypothetical protein 297245006352 Fic/DOC family; Region: Fic; pfam02661 297245006353 Fic family protein [Function unknown]; Region: COG3177 297245006354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245006355 salt bridge; other site 297245006356 non-specific DNA binding site [nucleotide binding]; other site 297245006357 sequence-specific DNA binding site [nucleotide binding]; other site 297245006358 HipA N-terminal domain; Region: couple_hipA; TIGR03071 297245006359 HipA-like N-terminal domain; Region: HipA_N; pfam07805 297245006360 HipA-like C-terminal domain; Region: HipA_C; pfam07804 297245006361 HTH-like domain; Region: HTH_21; pfam13276 297245006362 Integrase core domain; Region: rve; pfam00665 297245006363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 297245006364 Integrase core domain; Region: rve_3; pfam13683 297245006365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245006366 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 297245006367 Walker A motif; other site 297245006368 ATP binding site [chemical binding]; other site 297245006369 Walker B motif; other site 297245006370 Mrr N-terminal domain; Region: Mrr_N; pfam14338 297245006371 Restriction endonuclease; Region: Mrr_cat; pfam04471 297245006372 Similar to transposase, truncated;hypothetical protein 297245006373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006374 S-adenosylmethionine binding site [chemical binding]; other site 297245006375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245006376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245006377 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 297245006378 putative effector binding pocket; other site 297245006379 dimerization interface [polypeptide binding]; other site 297245006380 potassium uptake protein; Region: kup; TIGR00794 297245006381 K+ potassium transporter; Region: K_trans; pfam02705 297245006382 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 297245006383 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 297245006384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245006385 NAD(P) binding site [chemical binding]; other site 297245006386 active site 297245006387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 297245006388 Ligand Binding Site [chemical binding]; other site 297245006389 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 297245006390 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 297245006391 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 297245006392 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 297245006393 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 297245006394 Soluble P-type ATPase [General function prediction only]; Region: COG4087 297245006395 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 297245006396 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 297245006397 Ligand Binding Site [chemical binding]; other site 297245006398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 297245006399 Ligand Binding Site [chemical binding]; other site 297245006400 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 297245006401 AAA domain; Region: AAA_18; pfam13238 297245006402 active site 297245006403 outer membrane protease; Reviewed; Region: PRK10993 297245006404 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 297245006405 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 297245006406 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 297245006407 dimer interface [polypeptide binding]; other site 297245006408 active site 297245006409 heme binding site [chemical binding]; other site 297245006410 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 297245006411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006412 metabolite-proton symporter; Region: 2A0106; TIGR00883 297245006413 putative substrate translocation pore; other site 297245006414 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245006415 Substrate binding site [chemical binding]; other site 297245006416 Ferritin-like domain; Region: Ferritin; pfam00210 297245006417 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 297245006418 dinuclear metal binding motif [ion binding]; other site 297245006419 Methyltransferase domain; Region: Methyltransf_31; pfam13847 297245006420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006421 S-adenosylmethionine binding site [chemical binding]; other site 297245006422 Peptidase family M23; Region: Peptidase_M23; pfam01551 297245006423 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 297245006424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 297245006425 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 297245006426 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 297245006427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 297245006428 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245006429 Leucine-rich repeats; other site 297245006430 Substrate binding site [chemical binding]; other site 297245006431 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 297245006432 Beta-lactamase; Region: Beta-lactamase; pfam00144 297245006433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 297245006434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 297245006435 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 297245006436 putative substrate binding pocket [chemical binding]; other site 297245006437 putative dimerization interface [polypeptide binding]; other site 297245006438 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 297245006439 Cytochrome P450; Region: p450; cl12078 297245006440 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 297245006441 nudix motif; other site 297245006442 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 297245006443 Leucine-rich repeats; other site 297245006444 Substrate binding site [chemical binding]; other site 297245006445 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 297245006446 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 297245006447 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 297245006448 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 297245006449 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 297245006450 GAF domain; Region: GAF_3; pfam13492 297245006451 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245006452 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245006453 metal binding site [ion binding]; metal-binding site 297245006454 active site 297245006455 I-site; other site 297245006456 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 297245006457 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 297245006458 active site 297245006459 nucleophile elbow; other site 297245006460 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 297245006461 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 297245006462 Ras GTPase Activating Domain; Region: RasGAP; cl02569 297245006463 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 297245006464 Beta-lactamase; Region: Beta-lactamase; pfam00144 297245006465 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 297245006466 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 297245006467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245006468 Coenzyme A binding pocket [chemical binding]; other site 297245006469 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 297245006470 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245006471 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 297245006472 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245006473 Similar to N -terminal part of malonate decarboxylase, alpha subunit;hypothetical protein 297245006474 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 297245006475 SEC-C motif; Region: SEC-C; pfam02810 297245006476 Similar to C-terminal part of alkaline phosphatase;hypothetical protein 297245006477 Cupin domain; Region: Cupin_2; cl17218 297245006478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245006480 putative substrate translocation pore; other site 297245006481 Predicted flavoprotein [General function prediction only]; Region: COG0431 297245006482 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 297245006483 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 297245006484 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 297245006485 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 297245006486 putative dimer interface [polypeptide binding]; other site 297245006487 N-terminal domain interface [polypeptide binding]; other site 297245006488 putative substrate binding pocket (H-site) [chemical binding]; other site 297245006489 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 297245006490 dimer interface [polypeptide binding]; other site 297245006491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 297245006492 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 297245006493 N-acetyltransferase; Region: Acetyltransf_2; cl00949 297245006494 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 297245006495 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 297245006496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 297245006497 Coenzyme A binding pocket [chemical binding]; other site 297245006498 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 297245006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245006500 active site 297245006501 phosphorylation site [posttranslational modification] 297245006502 intermolecular recognition site; other site 297245006503 dimerization interface [polypeptide binding]; other site 297245006504 PAS domain S-box; Region: sensory_box; TIGR00229 297245006505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 297245006506 putative active site [active] 297245006507 heme pocket [chemical binding]; other site 297245006508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245006509 dimer interface [polypeptide binding]; other site 297245006510 phosphorylation site [posttranslational modification] 297245006511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245006512 ATP binding site [chemical binding]; other site 297245006513 Mg2+ binding site [ion binding]; other site 297245006514 G-X-G motif; other site 297245006515 Heme NO binding; Region: HNOB; pfam07700 297245006516 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 297245006517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006518 S-adenosylmethionine binding site [chemical binding]; other site 297245006519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245006521 putative substrate translocation pore; other site 297245006522 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 297245006523 guanine nucleotide-exchange factor domain of Legionella SidM/DrrA; Region: SidM_DrrA_GEF; cd11689 297245006524 Rab1 interaction interface [polypeptide binding]; other site 297245006525 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 297245006526 nickel binding site [ion binding]; other site 297245006527 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 297245006528 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 297245006529 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 297245006530 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 297245006531 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 297245006532 FAD binding pocket [chemical binding]; other site 297245006533 FAD binding motif [chemical binding]; other site 297245006534 phosphate binding motif [ion binding]; other site 297245006535 beta-alpha-beta structure motif; other site 297245006536 NAD binding pocket [chemical binding]; other site 297245006537 Iron coordination center [ion binding]; other site 297245006538 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 297245006539 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 297245006540 dimerization interface [polypeptide binding]; other site 297245006541 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 297245006542 ATP binding site [chemical binding]; other site 297245006543 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 297245006544 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 297245006545 HupF/HypC family; Region: HupF_HypC; pfam01455 297245006546 Acylphosphatase; Region: Acylphosphatase; pfam00708 297245006547 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 297245006548 HypF finger; Region: zf-HYPF; pfam07503 297245006549 HypF finger; Region: zf-HYPF; pfam07503 297245006550 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 297245006551 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 297245006552 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 297245006553 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 297245006554 High-affinity nickel-transport protein; Region: NicO; cl00964 297245006555 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 297245006556 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 297245006557 Ligand binding site; other site 297245006558 Putative Catalytic site; other site 297245006559 DXD motif; other site 297245006560 GtrA-like protein; Region: GtrA; pfam04138 297245006561 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 297245006562 putative active site [active] 297245006563 YdjC motif; other site 297245006564 Mg binding site [ion binding]; other site 297245006565 putative homodimer interface [polypeptide binding]; other site 297245006566 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 297245006567 EamA-like transporter family; Region: EamA; pfam00892 297245006568 EamA-like transporter family; Region: EamA; pfam00892 297245006569 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245006570 Uncharacterized conserved protein [Function unknown]; Region: COG2128 297245006571 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 297245006572 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 297245006573 active site 297245006574 dimerization interface [polypeptide binding]; other site 297245006575 TPR repeat; Region: TPR_11; pfam13414 297245006576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245006577 binding surface 297245006578 TPR motif; other site 297245006579 TPR repeat; Region: TPR_11; pfam13414 297245006580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245006581 binding surface 297245006582 TPR repeat; Region: TPR_11; pfam13414 297245006583 TPR motif; other site 297245006584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245006585 TPR motif; other site 297245006586 TPR repeat; Region: TPR_11; pfam13414 297245006587 binding surface 297245006588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245006589 binding surface 297245006590 TPR repeat; Region: TPR_11; pfam13414 297245006591 TPR motif; other site 297245006592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245006593 binding surface 297245006594 TPR motif; other site 297245006595 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 297245006596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 297245006597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006598 S-adenosylmethionine binding site [chemical binding]; other site 297245006599 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 297245006600 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 297245006601 active site 297245006602 substrate binding site [chemical binding]; other site 297245006603 metal binding site [ion binding]; metal-binding site 297245006604 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 297245006605 trimer interface [polypeptide binding]; other site 297245006606 active site 297245006607 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 297245006608 Flavoprotein; Region: Flavoprotein; pfam02441 297245006609 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 297245006610 hypothetical protein; Reviewed; Region: PRK00024 297245006611 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 297245006612 MPN+ (JAMM) motif; other site 297245006613 Zinc-binding site [ion binding]; other site 297245006614 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 297245006615 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 297245006616 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 297245006617 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 297245006618 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 297245006619 putative NAD(P) binding site [chemical binding]; other site 297245006620 putative substrate binding site [chemical binding]; other site 297245006621 catalytic Zn binding site [ion binding]; other site 297245006622 structural Zn binding site [ion binding]; other site 297245006623 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 297245006624 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 297245006625 putative dimer interface [polypeptide binding]; other site 297245006626 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 297245006627 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 297245006628 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 297245006629 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 297245006630 Thiamine pyrophosphokinase; Region: TPK; cd07995 297245006631 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 297245006632 active site 297245006633 dimerization interface [polypeptide binding]; other site 297245006634 thiamine binding site [chemical binding]; other site 297245006635 PQ loop repeat; Region: PQ-loop; pfam04193 297245006636 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 297245006637 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 297245006638 active site clefts [active] 297245006639 zinc binding site [ion binding]; other site 297245006640 dimer interface [polypeptide binding]; other site 297245006641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 297245006643 putative substrate translocation pore; other site 297245006644 acyltransferase PapA5; Provisional; Region: PRK09294 297245006645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 297245006646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 297245006647 dimer interface [polypeptide binding]; other site 297245006648 phosphorylation site [posttranslational modification] 297245006649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245006650 ATP binding site [chemical binding]; other site 297245006651 Mg2+ binding site [ion binding]; other site 297245006652 G-X-G motif; other site 297245006653 Dot/Icm substrate protein; Region: SidE; pfam12252 297245006654 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 297245006655 Protein export membrane protein; Region: SecD_SecF; cl14618 297245006656 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 297245006657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245006658 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245006659 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 297245006660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 297245006661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006662 D-galactonate transporter; Region: 2A0114; TIGR00893 297245006663 putative substrate translocation pore; other site 297245006664 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 297245006665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 297245006666 putative DNA binding site [nucleotide binding]; other site 297245006667 putative Zn2+ binding site [ion binding]; other site 297245006668 AsnC family; Region: AsnC_trans_reg; pfam01037 297245006669 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 297245006670 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 297245006671 dimer interface [polypeptide binding]; other site 297245006672 active site 297245006673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 297245006674 substrate binding site [chemical binding]; other site 297245006675 catalytic residue [active] 297245006676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 297245006677 DNA binding residues [nucleotide binding] 297245006678 dimerization interface [polypeptide binding]; other site 297245006679 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 297245006680 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 297245006681 active site 297245006682 catalytic site [active] 297245006683 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 297245006684 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 297245006685 Prephenate dehydratase; Region: PDT; pfam00800 297245006686 Chorismate mutase type II; Region: CM_2; smart00830 297245006687 aspartate aminotransferase; Provisional; Region: PRK05764 297245006688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 297245006689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245006690 homodimer interface [polypeptide binding]; other site 297245006691 catalytic residue [active] 297245006692 tellurite resistance protein TehB; Provisional; Region: PRK12335 297245006693 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 297245006694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006695 S-adenosylmethionine binding site [chemical binding]; other site 297245006696 Transcriptional regulator; Region: Rrf2; cl17282 297245006697 Rrf2 family protein; Region: rrf2_super; TIGR00738 297245006698 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 297245006699 apolar tunnel; other site 297245006700 heme binding site [chemical binding]; other site 297245006701 dimerization interface [polypeptide binding]; other site 297245006702 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 297245006703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 297245006704 catalytic loop [active] 297245006705 iron binding site [ion binding]; other site 297245006706 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 297245006707 FAD binding pocket [chemical binding]; other site 297245006708 FAD binding motif [chemical binding]; other site 297245006709 phosphate binding motif [ion binding]; other site 297245006710 beta-alpha-beta structure motif; other site 297245006711 NAD binding pocket [chemical binding]; other site 297245006712 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 297245006713 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 297245006714 MltA specific insert domain; Region: MltA; cl08398 297245006715 3D domain; Region: 3D; pfam06725 297245006716 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 297245006717 dimer interface [polypeptide binding]; other site 297245006718 putative tRNA-binding site [nucleotide binding]; other site 297245006719 EamA-like transporter family; Region: EamA; pfam00892 297245006720 EamA-like transporter family; Region: EamA; pfam00892 297245006721 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 297245006722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 297245006723 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 297245006724 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 297245006725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006726 putative substrate translocation pore; other site 297245006727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245006728 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 297245006729 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 297245006730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 297245006731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 297245006732 active site 297245006733 ATP binding site [chemical binding]; other site 297245006734 substrate binding site [chemical binding]; other site 297245006735 activation loop (A-loop); other site 297245006736 Acid Phosphatase; Region: Acid_PPase; cl17256 297245006737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 297245006738 Similar to rare lipoprotein A, truncated;hypothetical protein 297245006739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 297245006740 active site 297245006741 motif I; other site 297245006742 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 297245006743 motif II; other site 297245006744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 297245006745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 297245006746 active site 297245006747 ATP binding site [chemical binding]; other site 297245006748 substrate binding site [chemical binding]; other site 297245006749 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 297245006750 substrate binding site [chemical binding]; other site 297245006751 activation loop (A-loop); other site 297245006752 activation loop (A-loop); other site 297245006753 PAS domain; Region: PAS_9; pfam13426 297245006754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 297245006755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 297245006756 DNA binding residues [nucleotide binding] 297245006757 dimerization interface [polypeptide binding]; other site 297245006758 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 297245006759 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 297245006760 HSP70 interaction site [polypeptide binding]; other site 297245006761 integrase; Provisional; Region: PRK09692 297245006762 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 297245006763 active site 297245006764 Int/Topo IB signature motif; other site 297245006765 Virulence protein [General function prediction only]; Region: COG3943 297245006766 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 297245006767 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 297245006768 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 297245006769 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 297245006770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245006771 ATP binding site [chemical binding]; other site 297245006772 putative Mg++ binding site [ion binding]; other site 297245006773 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 297245006774 putative active site [active] 297245006775 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 297245006776 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 297245006777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245006778 ATP binding site [chemical binding]; other site 297245006779 putative Mg++ binding site [ion binding]; other site 297245006780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 297245006781 nucleotide binding region [chemical binding]; other site 297245006782 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 297245006783 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 297245006784 Uncharacterized conserved protein [Function unknown]; Region: COG3189 297245006785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 297245006786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 297245006787 active site 297245006788 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 297245006789 tetramer interface [polypeptide binding]; other site 297245006790 TPP-binding site [chemical binding]; other site 297245006791 heterodimer interface [polypeptide binding]; other site 297245006792 phosphorylation loop region [posttranslational modification] 297245006793 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 297245006794 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 297245006795 PYR/PP interface [polypeptide binding]; other site 297245006796 dimer interface [polypeptide binding]; other site 297245006797 TPP binding site [chemical binding]; other site 297245006798 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 297245006799 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 297245006800 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 297245006801 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 297245006802 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 297245006803 active site 297245006804 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 297245006805 active site 297245006806 catalytic triad [active] 297245006807 oxyanion hole [active] 297245006808 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 297245006809 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 297245006810 active site 297245006811 metal binding site [ion binding]; metal-binding site 297245006812 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 297245006813 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 297245006814 ParB-like nuclease domain; Region: ParBc; pfam02195 297245006815 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 297245006816 16S rRNA methyltransferase B; Provisional; Region: PRK10901 297245006817 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 297245006818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245006819 S-adenosylmethionine binding site [chemical binding]; other site 297245006820 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 297245006821 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 297245006822 putative active site [active] 297245006823 substrate binding site [chemical binding]; other site 297245006824 putative cosubstrate binding site; other site 297245006825 catalytic site [active] 297245006826 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 297245006827 substrate binding site [chemical binding]; other site 297245006828 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 297245006829 active site 297245006830 catalytic residues [active] 297245006831 metal binding site [ion binding]; metal-binding site 297245006832 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245006833 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 297245006834 DNA protecting protein DprA; Region: dprA; TIGR00732 297245006835 Protein of unknown function (DUF494); Region: DUF494; pfam04361 297245006836 DNA topoisomerase I; Validated; Region: PRK06599 297245006837 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 297245006838 active site 297245006839 interdomain interaction site; other site 297245006840 putative metal-binding site [ion binding]; other site 297245006841 nucleotide binding site [chemical binding]; other site 297245006842 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 297245006843 domain I; other site 297245006844 DNA binding groove [nucleotide binding] 297245006845 phosphate binding site [ion binding]; other site 297245006846 domain II; other site 297245006847 domain III; other site 297245006848 nucleotide binding site [chemical binding]; other site 297245006849 catalytic site [active] 297245006850 domain IV; other site 297245006851 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 297245006852 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 297245006853 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 297245006854 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 297245006855 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 297245006856 Bacterial PH domain; Region: DUF304; pfam03703 297245006857 Protein of unknown function (DUF721); Region: DUF721; pfam05258 297245006858 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 297245006859 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 297245006860 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 297245006861 Uncharacterized conserved protein [Function unknown]; Region: COG4278 297245006862 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 297245006863 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 297245006864 putative active site [active] 297245006865 putative dimer interface [polypeptide binding]; other site 297245006866 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 297245006867 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 297245006868 active site 297245006869 Zn binding site [ion binding]; other site 297245006870 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 297245006871 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 297245006872 cell division protein FtsZ; Validated; Region: PRK09330 297245006873 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 297245006874 nucleotide binding site [chemical binding]; other site 297245006875 SulA interaction site; other site 297245006876 cell division protein FtsA; Region: ftsA; TIGR01174 297245006877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 297245006878 nucleotide binding site [chemical binding]; other site 297245006879 Cell division protein FtsA; Region: FtsA; pfam14450 297245006880 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 297245006881 Cell division protein FtsQ; Region: FtsQ; pfam03799 297245006882 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 297245006883 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 297245006884 ATP-grasp domain; Region: ATP-grasp_4; cl17255 297245006885 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 297245006886 FAD binding domain; Region: FAD_binding_4; pfam01565 297245006887 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 297245006888 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 297245006889 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 297245006890 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 297245006891 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 297245006892 cell division protein FtsW; Region: ftsW; TIGR02614 297245006893 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 297245006894 TrkA-N domain; Region: TrkA_N; pfam02254 297245006895 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 297245006896 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 297245006897 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 297245006898 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 297245006899 Mg++ binding site [ion binding]; other site 297245006900 putative catalytic motif [active] 297245006901 putative substrate binding site [chemical binding]; other site 297245006902 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 297245006903 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 297245006904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 297245006905 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 297245006906 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 297245006907 FtsZ protein binding site [polypeptide binding]; other site 297245006908 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 297245006909 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 297245006910 Walker A/P-loop; other site 297245006911 ATP binding site [chemical binding]; other site 297245006912 Q-loop/lid; other site 297245006913 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 297245006914 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 297245006915 Q-loop/lid; other site 297245006916 ABC transporter signature motif; other site 297245006917 Walker B; other site 297245006918 D-loop; other site 297245006919 H-loop/switch region; other site 297245006920 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 297245006921 OmpW family; Region: OmpW; cl17427 297245006922 Alpha-amylase domain; Region: Aamy; smart00642 297245006923 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 297245006924 active site 297245006925 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 297245006926 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 297245006927 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 297245006928 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 297245006929 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 297245006930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 297245006931 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 297245006932 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 297245006933 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 297245006934 ATP-grasp domain; Region: ATP-grasp_4; cl17255 297245006935 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 297245006936 IMP binding site; other site 297245006937 dimer interface [polypeptide binding]; other site 297245006938 interdomain contacts; other site 297245006939 partial ornithine binding site; other site 297245006940 Predicted flavoproteins [General function prediction only]; Region: COG2081 297245006941 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 297245006942 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 297245006943 putative active site [active] 297245006944 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 297245006945 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 297245006946 Predicted permeases [General function prediction only]; Region: COG0795 297245006947 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 297245006948 multifunctional aminopeptidase A; Provisional; Region: PRK00913 297245006949 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 297245006950 interface (dimer of trimers) [polypeptide binding]; other site 297245006951 Substrate-binding/catalytic site; other site 297245006952 Zn-binding sites [ion binding]; other site 297245006953 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 297245006954 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 297245006955 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 297245006956 interface (dimer of trimers) [polypeptide binding]; other site 297245006957 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 297245006958 Substrate-binding/catalytic site; other site 297245006959 Zn-binding sites [ion binding]; other site 297245006960 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 297245006961 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 297245006962 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 297245006963 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245006964 Sel1-like repeats; Region: SEL1; smart00671 297245006965 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245006966 Sel1-like repeats; Region: SEL1; smart00671 297245006967 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 297245006968 Sel1-like repeats; Region: SEL1; smart00671 297245006969 Sel1-like repeats; Region: SEL1; smart00671 297245006970 Sel1-like repeats; Region: SEL1; smart00671 297245006971 Sel1-like repeats; Region: SEL1; smart00671 297245006972 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 297245006973 Similar to N-terminal part of regulatory protein (GGDEF and EAL domains);hypothetical protein 297245006974 Similar to C-terminal part of regulatory protein (GGDEF and EAL domains);hypothetical protein 297245006975 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 297245006976 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 297245006977 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 297245006978 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 297245006979 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 297245006980 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 297245006981 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 297245006982 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 297245006983 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 297245006984 GIY-YIG motif/motif A; other site 297245006985 active site 297245006986 catalytic site [active] 297245006987 putative DNA binding site [nucleotide binding]; other site 297245006988 metal binding site [ion binding]; metal-binding site 297245006989 UvrB/uvrC motif; Region: UVR; pfam02151 297245006990 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 297245006991 response regulator; Provisional; Region: PRK09483 297245006992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245006993 active site 297245006994 phosphorylation site [posttranslational modification] 297245006995 intermolecular recognition site; other site 297245006996 dimerization interface [polypeptide binding]; other site 297245006997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 297245006998 DNA binding residues [nucleotide binding] 297245006999 dimerization interface [polypeptide binding]; other site 297245007000 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 297245007001 cofactor binding site; other site 297245007002 metal binding site [ion binding]; metal-binding site 297245007003 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 297245007004 competence damage-inducible protein A; Provisional; Region: PRK01215 297245007005 putative MPT binding site; other site 297245007006 GTPase CgtA; Reviewed; Region: obgE; PRK12299 297245007007 GTP1/OBG; Region: GTP1_OBG; pfam01018 297245007008 Obg GTPase; Region: Obg; cd01898 297245007009 G1 box; other site 297245007010 GTP/Mg2+ binding site [chemical binding]; other site 297245007011 Switch I region; other site 297245007012 G2 box; other site 297245007013 G3 box; other site 297245007014 Switch II region; other site 297245007015 G4 box; other site 297245007016 G5 box; other site 297245007017 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 297245007018 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 297245007019 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 297245007020 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 297245007021 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 297245007022 5S rRNA interface [nucleotide binding]; other site 297245007023 CTC domain interface [polypeptide binding]; other site 297245007024 L16 interface [polypeptide binding]; other site 297245007025 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 297245007026 putative active site [active] 297245007027 catalytic residue [active] 297245007028 GTP-binding protein YchF; Reviewed; Region: PRK09601 297245007029 YchF GTPase; Region: YchF; cd01900 297245007030 G1 box; other site 297245007031 GTP/Mg2+ binding site [chemical binding]; other site 297245007032 Switch I region; other site 297245007033 G2 box; other site 297245007034 Switch II region; other site 297245007035 G3 box; other site 297245007036 G4 box; other site 297245007037 G5 box; other site 297245007038 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 297245007039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245007040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245007041 metal binding site [ion binding]; metal-binding site 297245007042 active site 297245007043 I-site; other site 297245007044 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 297245007045 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 297245007046 substrate binding pocket [chemical binding]; other site 297245007047 chain length determination region; other site 297245007048 substrate-Mg2+ binding site; other site 297245007049 catalytic residues [active] 297245007050 aspartate-rich region 1; other site 297245007051 active site lid residues [active] 297245007052 aspartate-rich region 2; other site 297245007053 FeoC like transcriptional regulator; Region: FeoC; pfam09012 297245007054 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 297245007055 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 297245007056 G1 box; other site 297245007057 GTP/Mg2+ binding site [chemical binding]; other site 297245007058 Switch I region; other site 297245007059 G2 box; other site 297245007060 G3 box; other site 297245007061 Switch II region; other site 297245007062 G4 box; other site 297245007063 G5 box; other site 297245007064 Nucleoside recognition; Region: Gate; pfam07670 297245007065 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 297245007066 Nucleoside recognition; Region: Gate; pfam07670 297245007067 FeoA domain; Region: FeoA; pfam04023 297245007068 Predicted ATPase [General function prediction only]; Region: COG1485 297245007069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245007070 Walker A motif; other site 297245007071 ATP binding site [chemical binding]; other site 297245007072 Walker B motif; other site 297245007073 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 297245007074 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 297245007075 oligomerization interface [polypeptide binding]; other site 297245007076 active site 297245007077 metal binding site [ion binding]; metal-binding site 297245007078 pantoate--beta-alanine ligase; Region: panC; TIGR00018 297245007079 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 297245007080 active site 297245007081 nucleotide binding site [chemical binding]; other site 297245007082 HIGH motif; other site 297245007083 KMSKS motif; other site 297245007084 AAA domain; Region: AAA_28; pfam13521 297245007085 Predicted ATPase [General function prediction only]; Region: COG3911 297245007086 pyruvate carboxylase subunit A; Validated; Region: PRK07178 297245007087 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 297245007088 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 297245007089 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 297245007090 Dienelactone hydrolase family; Region: DLH; pfam01738 297245007091 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 297245007092 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245007093 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 297245007094 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 297245007095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 297245007096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 297245007097 DNA binding residues [nucleotide binding] 297245007098 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 297245007099 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 297245007100 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 297245007101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245007102 Walker A/P-loop; other site 297245007103 ATP binding site [chemical binding]; other site 297245007104 Q-loop/lid; other site 297245007105 ABC transporter signature motif; other site 297245007106 Walker B; other site 297245007107 D-loop; other site 297245007108 H-loop/switch region; other site 297245007109 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 297245007110 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 297245007111 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 297245007112 P loop; other site 297245007113 GTP binding site [chemical binding]; other site 297245007114 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 297245007115 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 297245007116 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 297245007117 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 297245007118 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 297245007119 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 297245007120 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 297245007121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007122 S-adenosylmethionine binding site [chemical binding]; other site 297245007123 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 297245007124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 297245007125 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 297245007126 Walker A motif; other site 297245007127 Walker A/P-loop; other site 297245007128 ATP binding site [chemical binding]; other site 297245007129 ATP binding site [chemical binding]; other site 297245007130 Walker B motif; other site 297245007131 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 297245007132 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 297245007133 putative active site [active] 297245007134 putative metal binding site [ion binding]; other site 297245007135 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 297245007136 Methyltransferase domain; Region: Methyltransf_23; pfam13489 297245007137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007138 S-adenosylmethionine binding site [chemical binding]; other site 297245007139 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 297245007140 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 297245007141 NAD binding site [chemical binding]; other site 297245007142 ATP-grasp domain; Region: ATP-grasp_4; cl17255 297245007143 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 297245007144 active site 297245007145 catalytic residues [active] 297245007146 metal binding site [ion binding]; metal-binding site 297245007147 tartrate dehydrogenase; Provisional; Region: PRK08194 297245007148 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 297245007149 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 297245007150 Dienelactone hydrolase family; Region: DLH; pfam01738 297245007151 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 297245007152 Phagosome trafficking protein DotA; Region: DotA; pfam11388 297245007153 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 297245007154 putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539 297245007155 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 297245007156 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 297245007157 metal-binding site [ion binding] 297245007158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 297245007159 Methyltransferase domain; Region: Methyltransf_31; pfam13847 297245007160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007161 S-adenosylmethionine binding site [chemical binding]; other site 297245007162 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 297245007163 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 297245007164 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 297245007165 putative active site [active] 297245007166 Zinc-finger domain; Region: zf-CHCC; cl01821 297245007167 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 297245007168 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 297245007169 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 297245007170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245007171 ATP binding site [chemical binding]; other site 297245007172 Mg2+ binding site [ion binding]; other site 297245007173 G-X-G motif; other site 297245007174 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 297245007175 ATP binding site [chemical binding]; other site 297245007176 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 297245007177 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 297245007178 AMIN domain; Region: AMIN; pfam11741 297245007179 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 297245007180 active site 297245007181 metal binding site [ion binding]; metal-binding site 297245007182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 297245007183 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 297245007184 putative carbohydrate kinase; Provisional; Region: PRK10565 297245007185 Uncharacterized conserved protein [Function unknown]; Region: COG0062 297245007186 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 297245007187 putative substrate binding site [chemical binding]; other site 297245007188 putative ATP binding site [chemical binding]; other site 297245007189 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 297245007190 stringent starvation protein A; Provisional; Region: sspA; PRK09481 297245007191 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 297245007192 C-terminal domain interface [polypeptide binding]; other site 297245007193 putative GSH binding site (G-site) [chemical binding]; other site 297245007194 dimer interface [polypeptide binding]; other site 297245007195 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 297245007196 dimer interface [polypeptide binding]; other site 297245007197 N-terminal domain interface [polypeptide binding]; other site 297245007198 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 297245007199 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 297245007200 Qi binding site; other site 297245007201 intrachain domain interface; other site 297245007202 interchain domain interface [polypeptide binding]; other site 297245007203 cytochrome b; Validated; Region: CYTB; MTH00016 297245007204 heme bH binding site [chemical binding]; other site 297245007205 heme bL binding site [chemical binding]; other site 297245007206 Qo binding site; other site 297245007207 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 297245007208 interchain domain interface [polypeptide binding]; other site 297245007209 intrachain domain interface; other site 297245007210 Qi binding site; other site 297245007211 Qo binding site; other site 297245007212 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 297245007213 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 297245007214 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 297245007215 [2Fe-2S] cluster binding site [ion binding]; other site 297245007216 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 297245007217 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 297245007218 23S rRNA interface [nucleotide binding]; other site 297245007219 L3 interface [polypeptide binding]; other site 297245007220 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 297245007221 dimer interface [polypeptide binding]; other site 297245007222 [2Fe-2S] cluster binding site [ion binding]; other site 297245007223 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 297245007224 IHF - DNA interface [nucleotide binding]; other site 297245007225 IHF dimer interface [polypeptide binding]; other site 297245007226 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 297245007227 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 297245007228 putative tRNA-binding site [nucleotide binding]; other site 297245007229 B3/4 domain; Region: B3_4; pfam03483 297245007230 tRNA synthetase B5 domain; Region: B5; pfam03484 297245007231 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 297245007232 dimer interface [polypeptide binding]; other site 297245007233 motif 1; other site 297245007234 motif 3; other site 297245007235 motif 2; other site 297245007236 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 297245007237 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 297245007238 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 297245007239 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 297245007240 dimer interface [polypeptide binding]; other site 297245007241 motif 1; other site 297245007242 active site 297245007243 motif 2; other site 297245007244 motif 3; other site 297245007245 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 297245007246 23S rRNA binding site [nucleotide binding]; other site 297245007247 L21 binding site [polypeptide binding]; other site 297245007248 L13 binding site [polypeptide binding]; other site 297245007249 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 297245007250 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 297245007251 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 297245007252 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 297245007253 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 297245007254 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 297245007255 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 297245007256 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 297245007257 active site 297245007258 dimer interface [polypeptide binding]; other site 297245007259 motif 1; other site 297245007260 motif 2; other site 297245007261 motif 3; other site 297245007262 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 297245007263 anticodon binding site; other site 297245007264 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 297245007265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245007266 non-specific DNA binding site [nucleotide binding]; other site 297245007267 salt bridge; other site 297245007268 sequence-specific DNA binding site [nucleotide binding]; other site 297245007269 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 297245007270 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 297245007271 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 297245007272 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 297245007273 ligand binding site [chemical binding]; other site 297245007274 flexible hinge region; other site 297245007275 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 297245007276 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 297245007277 ligand binding site [chemical binding]; other site 297245007278 flexible hinge region; other site 297245007279 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 297245007280 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 297245007281 putative active site [active] 297245007282 putative dimer interface [polypeptide binding]; other site 297245007283 Predicted membrane protein [Function unknown]; Region: COG2860 297245007284 UPF0126 domain; Region: UPF0126; pfam03458 297245007285 UPF0126 domain; Region: UPF0126; pfam03458 297245007286 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 297245007287 substrate binding site [chemical binding]; other site 297245007288 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 297245007289 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 297245007290 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 297245007291 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 297245007292 hypothetical protein; Provisional; Region: PRK07179 297245007293 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 297245007294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 297245007295 catalytic residue [active] 297245007296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245007297 active site 297245007298 phosphorylation site [posttranslational modification] 297245007299 intermolecular recognition site; other site 297245007300 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 297245007301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 297245007302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 297245007303 ATP binding site [chemical binding]; other site 297245007304 Mg2+ binding site [ion binding]; other site 297245007305 G-X-G motif; other site 297245007306 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 297245007307 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 297245007308 domain interfaces; other site 297245007309 active site 297245007310 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 297245007311 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 297245007312 active site 297245007313 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 297245007314 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 297245007315 HemY protein N-terminus; Region: HemY_N; pfam07219 297245007316 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 297245007317 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 297245007318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 297245007319 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 297245007320 catalytic site [active] 297245007321 putative active site [active] 297245007322 putative substrate binding site [chemical binding]; other site 297245007323 dimer interface [polypeptide binding]; other site 297245007324 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 297245007325 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 297245007326 active site 297245007327 NTP binding site [chemical binding]; other site 297245007328 metal binding triad [ion binding]; metal-binding site 297245007329 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 297245007330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 297245007331 Zn2+ binding site [ion binding]; other site 297245007332 Mg2+ binding site [ion binding]; other site 297245007333 GTPase RsgA; Reviewed; Region: PRK12288 297245007334 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 297245007335 RNA binding site [nucleotide binding]; other site 297245007336 homodimer interface [polypeptide binding]; other site 297245007337 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 297245007338 GTPase/Zn-binding domain interface [polypeptide binding]; other site 297245007339 GTP/Mg2+ binding site [chemical binding]; other site 297245007340 G4 box; other site 297245007341 G5 box; other site 297245007342 G1 box; other site 297245007343 Switch I region; other site 297245007344 G2 box; other site 297245007345 G3 box; other site 297245007346 Switch II region; other site 297245007347 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 297245007348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245007349 Walker A motif; other site 297245007350 ATP binding site [chemical binding]; other site 297245007351 Walker B motif; other site 297245007352 arginine finger; other site 297245007353 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 297245007354 hypothetical protein; Validated; Region: PRK00153 297245007355 recombination protein RecR; Reviewed; Region: recR; PRK00076 297245007356 RecR protein; Region: RecR; pfam02132 297245007357 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 297245007358 putative active site [active] 297245007359 putative metal-binding site [ion binding]; other site 297245007360 tetramer interface [polypeptide binding]; other site 297245007361 Protein of unknown function, DUF547; Region: DUF547; pfam04784 297245007362 Sulfatase; Region: Sulfatase; cl17466 297245007363 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 297245007364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 297245007365 active site 297245007366 dimerization interface [polypeptide binding]; other site 297245007367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 297245007368 DNA binding site [nucleotide binding] 297245007369 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 297245007370 Domain of unknown function DUF21; Region: DUF21; pfam01595 297245007371 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 297245007372 Transporter associated domain; Region: CorC_HlyC; smart01091 297245007373 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 297245007374 dimer interface [polypeptide binding]; other site 297245007375 substrate binding site [chemical binding]; other site 297245007376 metal binding sites [ion binding]; metal-binding site 297245007377 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 297245007378 nucleotide binding site/active site [active] 297245007379 HIT family signature motif; other site 297245007380 catalytic residue [active] 297245007381 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 297245007382 GTP cyclohydrolase I; Provisional; Region: PLN03044 297245007383 homodecamer interface [polypeptide binding]; other site 297245007384 active site 297245007385 putative catalytic site residues [active] 297245007386 zinc binding site [ion binding]; other site 297245007387 GTP-CH-I/GFRP interaction surface; other site 297245007388 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 297245007389 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 297245007390 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 297245007391 RNase E interface [polypeptide binding]; other site 297245007392 trimer interface [polypeptide binding]; other site 297245007393 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 297245007394 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 297245007395 RNase E interface [polypeptide binding]; other site 297245007396 trimer interface [polypeptide binding]; other site 297245007397 active site 297245007398 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 297245007399 putative nucleic acid binding region [nucleotide binding]; other site 297245007400 G-X-X-G motif; other site 297245007401 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 297245007402 RNA binding site [nucleotide binding]; other site 297245007403 domain interface; other site 297245007404 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 297245007405 16S/18S rRNA binding site [nucleotide binding]; other site 297245007406 S13e-L30e interaction site [polypeptide binding]; other site 297245007407 25S rRNA binding site [nucleotide binding]; other site 297245007408 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 297245007409 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 297245007410 RNA binding site [nucleotide binding]; other site 297245007411 active site 297245007412 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 297245007413 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 297245007414 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 297245007415 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 297245007416 translation initiation factor IF-2; Region: IF-2; TIGR00487 297245007417 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 297245007418 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 297245007419 G1 box; other site 297245007420 putative GEF interaction site [polypeptide binding]; other site 297245007421 GTP/Mg2+ binding site [chemical binding]; other site 297245007422 Switch I region; other site 297245007423 G2 box; other site 297245007424 G3 box; other site 297245007425 Switch II region; other site 297245007426 G4 box; other site 297245007427 G5 box; other site 297245007428 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 297245007429 Translation-initiation factor 2; Region: IF-2; pfam11987 297245007430 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 297245007431 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 297245007432 NusA N-terminal domain; Region: NusA_N; pfam08529 297245007433 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 297245007434 RNA binding site [nucleotide binding]; other site 297245007435 homodimer interface [polypeptide binding]; other site 297245007436 NusA-like KH domain; Region: KH_5; pfam13184 297245007437 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 297245007438 G-X-X-G motif; other site 297245007439 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 297245007440 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 297245007441 ribosome maturation protein RimP; Reviewed; Region: PRK00092 297245007442 hypothetical protein; Provisional; Region: PRK14641 297245007443 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 297245007444 putative oligomer interface [polypeptide binding]; other site 297245007445 putative RNA binding site [nucleotide binding]; other site 297245007446 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 297245007447 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 297245007448 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 297245007449 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 297245007450 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 297245007451 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 297245007452 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 297245007453 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 297245007454 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 297245007455 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 297245007456 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 297245007457 4Fe-4S binding domain; Region: Fer4; cl02805 297245007458 4Fe-4S binding domain; Region: Fer4; pfam00037 297245007459 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 297245007460 NADH dehydrogenase subunit G; Validated; Region: PRK09129 297245007461 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 297245007462 catalytic loop [active] 297245007463 iron binding site [ion binding]; other site 297245007464 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 297245007465 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 297245007466 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 297245007467 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 297245007468 SLBB domain; Region: SLBB; pfam10531 297245007469 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 297245007470 NADH dehydrogenase subunit E; Validated; Region: PRK07539 297245007471 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 297245007472 putative dimer interface [polypeptide binding]; other site 297245007473 [2Fe-2S] cluster binding site [ion binding]; other site 297245007474 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 297245007475 NADH dehydrogenase subunit D; Validated; Region: PRK06075 297245007476 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 297245007477 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 297245007478 NADH dehydrogenase subunit B; Validated; Region: PRK06411 297245007479 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 297245007480 Preprotein translocase SecG subunit; Region: SecG; pfam03840 297245007481 triosephosphate isomerase; Provisional; Region: PRK14567 297245007482 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 297245007483 substrate binding site [chemical binding]; other site 297245007484 dimer interface [polypeptide binding]; other site 297245007485 catalytic triad [active] 297245007486 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 297245007487 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 297245007488 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 297245007489 active site 297245007490 substrate binding site [chemical binding]; other site 297245007491 metal binding site [ion binding]; metal-binding site 297245007492 dihydropteroate synthase; Region: DHPS; TIGR01496 297245007493 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 297245007494 substrate binding pocket [chemical binding]; other site 297245007495 dimer interface [polypeptide binding]; other site 297245007496 inhibitor binding site; inhibition site 297245007497 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 297245007498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245007499 Walker A motif; other site 297245007500 ATP binding site [chemical binding]; other site 297245007501 Walker B motif; other site 297245007502 arginine finger; other site 297245007503 Peptidase family M41; Region: Peptidase_M41; pfam01434 297245007504 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 297245007505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007506 S-adenosylmethionine binding site [chemical binding]; other site 297245007507 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 297245007508 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 297245007509 IucA / IucC family; Region: IucA_IucC; pfam04183 297245007510 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 297245007511 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 297245007512 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 297245007513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 297245007514 Walker A motif; other site 297245007515 ATP binding site [chemical binding]; other site 297245007516 Walker B motif; other site 297245007517 arginine finger; other site 297245007518 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 297245007519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245007520 putative substrate translocation pore; other site 297245007521 POT family; Region: PTR2; cl17359 297245007522 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 297245007523 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 297245007524 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 297245007525 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 297245007526 shikimate binding site; other site 297245007527 NAD(P) binding site [chemical binding]; other site 297245007528 aminopeptidase N; Provisional; Region: pepN; PRK14015 297245007529 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 297245007530 active site 297245007531 Zn binding site [ion binding]; other site 297245007532 PrkA family serine protein kinase; Provisional; Region: PRK15455 297245007533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 297245007534 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 297245007535 hypothetical protein; Provisional; Region: PRK05325 297245007536 SpoVR family protein; Provisional; Region: PRK11767 297245007537 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 297245007538 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 297245007539 Peptidase family M28; Region: Peptidase_M28; pfam04389 297245007540 active site 297245007541 metal binding site [ion binding]; metal-binding site 297245007542 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 297245007543 Part of AAA domain; Region: AAA_19; pfam13245 297245007544 Family description; Region: UvrD_C_2; pfam13538 297245007545 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 297245007546 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 297245007547 dimerization interface [polypeptide binding]; other site 297245007548 domain crossover interface; other site 297245007549 redox-dependent activation switch; other site 297245007550 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 297245007551 Similar to N-terminal part of unknown protein;hypothetical protein 297245007552 Similar to central part of unknown protein;hypothetical protein 297245007553 Similar to C-terminal part of unknown protein;hypothetical protein 297245007554 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 297245007555 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 297245007556 G1 box; other site 297245007557 putative GEF interaction site [polypeptide binding]; other site 297245007558 GTP/Mg2+ binding site [chemical binding]; other site 297245007559 Switch I region; other site 297245007560 G2 box; other site 297245007561 G3 box; other site 297245007562 Switch II region; other site 297245007563 G4 box; other site 297245007564 G5 box; other site 297245007565 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 297245007566 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 297245007567 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 297245007568 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 297245007569 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 297245007570 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 297245007571 Walker A/P-loop; other site 297245007572 ATP binding site [chemical binding]; other site 297245007573 Q-loop/lid; other site 297245007574 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 297245007575 ABC transporter signature motif; other site 297245007576 Walker B; other site 297245007577 D-loop; other site 297245007578 H-loop/switch region; other site 297245007579 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 297245007580 DNA-binding site [nucleotide binding]; DNA binding site 297245007581 RNA-binding motif; other site 297245007582 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 297245007583 conserved cys residue [active] 297245007584 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 297245007585 Amidinotransferase; Region: Amidinotransf; pfam02274 297245007586 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 297245007587 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 297245007588 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 297245007589 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 297245007590 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 297245007591 RNA binding site [nucleotide binding]; other site 297245007592 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 297245007593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007594 S-adenosylmethionine binding site [chemical binding]; other site 297245007595 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 297245007596 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 297245007597 glutaminase active site [active] 297245007598 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 297245007599 dimer interface [polypeptide binding]; other site 297245007600 active site 297245007601 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 297245007602 dimer interface [polypeptide binding]; other site 297245007603 active site 297245007604 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 297245007605 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 297245007606 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 297245007607 active site 297245007608 oxyanion hole [active] 297245007609 catalytic triad [active] 297245007610 rhodanese superfamily protein; Provisional; Region: PRK05320 297245007611 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 297245007612 active site residue [active] 297245007613 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 297245007614 SmpB-tmRNA interface; other site 297245007615 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 297245007616 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 297245007617 catalytic triad [active] 297245007618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 297245007619 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 297245007620 putative substrate translocation pore; other site 297245007621 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 297245007622 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 297245007623 putative active site [active] 297245007624 PhoH-like protein; Region: PhoH; pfam02562 297245007625 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 297245007626 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 297245007627 active site 297245007628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 297245007629 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 297245007630 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 297245007631 B1 nucleotide binding pocket [chemical binding]; other site 297245007632 B2 nucleotide binding pocket [chemical binding]; other site 297245007633 CAS motifs; other site 297245007634 active site 297245007635 TPR repeat; Region: TPR_11; pfam13414 297245007636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245007637 TPR motif; other site 297245007638 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 297245007639 Methyltransferase domain; Region: Methyltransf_24; pfam13578 297245007640 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 297245007641 DNA-binding site [nucleotide binding]; DNA binding site 297245007642 RNA-binding motif; other site 297245007643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 297245007644 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 297245007645 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 297245007646 Amidase; Region: Amidase; cl11426 297245007647 Oxygen tolerance; Region: BatD; pfam13584 297245007648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 297245007649 binding surface 297245007650 TPR motif; other site 297245007651 Tetratricopeptide repeat; Region: TPR_16; pfam13432 297245007652 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 297245007653 metal ion-dependent adhesion site (MIDAS); other site 297245007654 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 297245007655 metal ion-dependent adhesion site (MIDAS); other site 297245007656 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 297245007657 Protein of unknown function DUF58; Region: DUF58; pfam01882 297245007658 MoxR-like ATPases [General function prediction only]; Region: COG0714 297245007659 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 297245007660 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 297245007661 FMN binding site [chemical binding]; other site 297245007662 active site 297245007663 catalytic residues [active] 297245007664 substrate binding site [chemical binding]; other site 297245007665 pteridine reductase; Provisional; Region: PRK09135 297245007666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 297245007667 NAD(P) binding site [chemical binding]; other site 297245007668 active site 297245007669 Uncharacterized conserved protein [Function unknown]; Region: COG1565 297245007670 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 297245007671 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 297245007672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 297245007673 ATP binding site [chemical binding]; other site 297245007674 putative Mg++ binding site [ion binding]; other site 297245007675 nucleotide binding region [chemical binding]; other site 297245007676 helicase superfamily c-terminal domain; Region: HELICc; smart00490 297245007677 ATP-binding site [chemical binding]; other site 297245007678 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 297245007679 active site 297245007680 thymidylate synthase; Reviewed; Region: thyA; PRK01827 297245007681 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 297245007682 dimerization interface [polypeptide binding]; other site 297245007683 active site 297245007684 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 297245007685 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 297245007686 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 297245007687 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 297245007688 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 297245007689 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 297245007690 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 297245007691 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 297245007692 putative active site [active] 297245007693 Ap4A binding site [chemical binding]; other site 297245007694 nudix motif; other site 297245007695 putative metal binding site [ion binding]; other site 297245007696 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 297245007697 active site 297245007698 homodimer interface [polypeptide binding]; other site 297245007699 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 297245007700 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 297245007701 Substrate binding site; other site 297245007702 Mg++ binding site; other site 297245007703 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 297245007704 active site 297245007705 substrate binding site [chemical binding]; other site 297245007706 CoA binding site [chemical binding]; other site 297245007707 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 297245007708 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 297245007709 transmembrane helices; other site 297245007710 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 297245007711 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 297245007712 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 297245007713 oligomer interface [polypeptide binding]; other site 297245007714 metal binding site [ion binding]; metal-binding site 297245007715 metal binding site [ion binding]; metal-binding site 297245007716 Cl binding site [ion binding]; other site 297245007717 aspartate ring; other site 297245007718 basic sphincter; other site 297245007719 putative hydrophobic gate; other site 297245007720 periplasmic entrance; other site 297245007721 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 297245007722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 297245007723 minor groove reading motif; other site 297245007724 helix-hairpin-helix signature motif; other site 297245007725 substrate binding pocket [chemical binding]; other site 297245007726 active site 297245007727 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 297245007728 ferredoxin; Provisional; Region: PRK08764 297245007729 Putative Fe-S cluster; Region: FeS; pfam04060 297245007730 4Fe-4S binding domain; Region: Fer4; pfam00037 297245007731 4Fe-4S binding domain; Region: Fer4; cl02805 297245007732 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 297245007733 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 297245007734 active site 297245007735 HIGH motif; other site 297245007736 KMSKS motif; other site 297245007737 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 297245007738 anticodon binding site; other site 297245007739 tRNA binding surface [nucleotide binding]; other site 297245007740 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 297245007741 dimer interface [polypeptide binding]; other site 297245007742 putative tRNA-binding site [nucleotide binding]; other site 297245007743 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 297245007744 Flavoprotein; Region: Flavoprotein; pfam02441 297245007745 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 297245007746 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 297245007747 Ligand Binding Site [chemical binding]; other site 297245007748 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 297245007749 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 297245007750 Substrate binding site; other site 297245007751 Cupin domain; Region: Cupin_2; cl17218 297245007752 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 297245007753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 297245007754 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 297245007755 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 297245007756 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 297245007757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007758 S-adenosylmethionine binding site [chemical binding]; other site 297245007759 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 297245007760 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 297245007761 P-loop; other site 297245007762 Magnesium ion binding site [ion binding]; other site 297245007763 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 297245007764 Magnesium ion binding site [ion binding]; other site 297245007765 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 297245007766 ParB-like nuclease domain; Region: ParBc; pfam02195 297245007767 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 297245007768 Subunit III/VIIa interface [polypeptide binding]; other site 297245007769 Phospholipid binding site [chemical binding]; other site 297245007770 Subunit I/III interface [polypeptide binding]; other site 297245007771 Subunit III/VIb interface [polypeptide binding]; other site 297245007772 Subunit III/VIa interface; other site 297245007773 Subunit III/Vb interface [polypeptide binding]; other site 297245007774 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 297245007775 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 297245007776 Subunit I/III interface [polypeptide binding]; other site 297245007777 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 297245007778 D-pathway; other site 297245007779 Subunit I/VIIc interface [polypeptide binding]; other site 297245007780 Subunit I/IV interface [polypeptide binding]; other site 297245007781 Subunit I/II interface [polypeptide binding]; other site 297245007782 Low-spin heme (heme a) binding site [chemical binding]; other site 297245007783 Subunit I/VIIa interface [polypeptide binding]; other site 297245007784 Subunit I/VIa interface [polypeptide binding]; other site 297245007785 Dimer interface; other site 297245007786 Putative water exit pathway; other site 297245007787 Binuclear center (heme a3/CuB) [ion binding]; other site 297245007788 K-pathway; other site 297245007789 Subunit I/Vb interface [polypeptide binding]; other site 297245007790 Putative proton exit pathway; other site 297245007791 Subunit I/VIb interface; other site 297245007792 Subunit I/VIc interface [polypeptide binding]; other site 297245007793 Electron transfer pathway; other site 297245007794 Subunit I/VIIIb interface [polypeptide binding]; other site 297245007795 Subunit I/VIIb interface [polypeptide binding]; other site 297245007796 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 297245007797 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168 297245007798 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 297245007799 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 297245007800 Cytochrome c; Region: Cytochrom_C; pfam00034 297245007801 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 297245007802 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 297245007803 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 297245007804 hypothetical protein; Provisional; Region: PTZ00378 297245007805 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 297245007806 iron-sulfur cluster [ion binding]; other site 297245007807 [2Fe-2S] cluster binding site [ion binding]; other site 297245007808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 297245007809 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 297245007810 Lysine efflux permease [General function prediction only]; Region: COG1279 297245007811 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 297245007812 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 297245007813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 297245007814 S-adenosylmethionine binding site [chemical binding]; other site 297245007815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 297245007816 SCP-2 sterol transfer family; Region: SCP2; pfam02036 297245007817 SCP-2 sterol transfer family; Region: SCP2; cl01225 297245007818 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 297245007819 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 297245007820 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 297245007821 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 297245007822 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 297245007823 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 297245007824 methionine sulfoxide reductase A; Provisional; Region: PRK14054 297245007825 GAF domain; Region: GAF_2; pfam13185 297245007826 GAF domain; Region: GAF; pfam01590 297245007827 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 297245007828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 297245007829 metal binding site [ion binding]; metal-binding site 297245007830 active site 297245007831 I-site; other site 297245007832 similar to C-terminal part of copper amine oxidase;hypothetical protein 297245007833 similar to N-terminal part of copper amine oxidase;hypothetical protein 297245007834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 297245007835 non-specific DNA binding site [nucleotide binding]; other site 297245007836 salt bridge; other site 297245007837 sequence-specific DNA binding site [nucleotide binding]; other site 297245007838 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 297245007839 Similar to transposase, truncated;hypothetical protein 297245007840 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 297245007841 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 297245007842 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 297245007843 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 297245007844 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 297245007845 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 297245007846 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 297245007847 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 297245007848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245007849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 297245007850 Transglycosylase SLT domain; Region: SLT_2; pfam13406 297245007851 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 297245007852 N-acetyl-D-glucosamine binding site [chemical binding]; other site 297245007853 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 297245007854 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 297245007855 active site 297245007856 NTP binding site [chemical binding]; other site 297245007857 metal binding triad [ion binding]; metal-binding site 297245007858 antibiotic binding site [chemical binding]; other site 297245007859 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 297245007860 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 297245007861 FtsX-like permease family; Region: FtsX; pfam02687 297245007862 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 297245007863 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 297245007864 Walker A/P-loop; other site 297245007865 ATP binding site [chemical binding]; other site 297245007866 Q-loop/lid; other site 297245007867 ABC transporter signature motif; other site 297245007868 Walker B; other site 297245007869 D-loop; other site 297245007870 H-loop/switch region; other site 297245007871 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 297245007872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 297245007873 HlyD family secretion protein; Region: HlyD_3; pfam13437 297245007874 Outer membrane efflux protein; Region: OEP; pfam02321 297245007875 Outer membrane efflux protein; Region: OEP; pfam02321 297245007876 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 297245007877 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 297245007878 active site 297245007879 metal binding site [ion binding]; metal-binding site 297245007880 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 297245007881 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 297245007882 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 297245007883 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 297245007884 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 297245007885 tetramerization interface [polypeptide binding]; other site 297245007886 active site 297245007887 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 297245007888 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 297245007889 FMN reductase; Validated; Region: fre; PRK08051 297245007890 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 297245007891 FAD binding pocket [chemical binding]; other site 297245007892 FAD binding motif [chemical binding]; other site 297245007893 phosphate binding motif [ion binding]; other site 297245007894 beta-alpha-beta structure motif; other site 297245007895 NAD binding pocket [chemical binding]; other site 297245007896 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 297245007897 transcription termination factor Rho; Provisional; Region: rho; PRK09376 297245007898 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 297245007899 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 297245007900 RNA binding site [nucleotide binding]; other site 297245007901 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 297245007902 multimer interface [polypeptide binding]; other site 297245007903 Walker A motif; other site 297245007904 ATP binding site [chemical binding]; other site 297245007905 Walker B motif; other site 297245007906 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 297245007907 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 297245007908 catalytic residues [active] 297245007909 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 297245007910 RNA methyltransferase, RsmE family; Region: TIGR00046 297245007911 fumarate hydratase; Reviewed; Region: fumC; PRK00485 297245007912 Class II fumarases; Region: Fumarase_classII; cd01362 297245007913 active site 297245007914 tetramer interface [polypeptide binding]; other site 297245007915 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 297245007916 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 297245007917 Homeodomain-like domain; Region: HTH_23; pfam13384 297245007918 Winged helix-turn helix; Region: HTH_29; pfam13551 297245007919 Winged helix-turn helix; Region: HTH_33; pfam13592 297245007920 DDE superfamily endonuclease; Region: DDE_3; pfam13358 297245007921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 297245007922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 297245007923 putative acyl-acceptor binding pocket; other site 297245007924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 297245007925 putative acyl-acceptor binding pocket; other site 297245007926 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 297245007927 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 297245007928 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 297245007929 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 297245007930 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 297245007931 trimer interface [polypeptide binding]; other site 297245007932 active site 297245007933 UDP-GlcNAc binding site [chemical binding]; other site 297245007934 lipid binding site [chemical binding]; lipid-binding site 297245007935 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 297245007936 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 297245007937 active site 297245007938 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 297245007939 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 297245007940 putative active site [active] 297245007941 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 297245007942 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 297245007943 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 297245007944 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 297245007945 dimer interface [polypeptide binding]; other site 297245007946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245007947 catalytic residue [active] 297245007948 Histone methylation protein DOT1; Region: DOT1; pfam08123 297245007949 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 297245007950 IHF dimer interface [polypeptide binding]; other site 297245007951 IHF - DNA interface [nucleotide binding]; other site 297245007952 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 297245007953 trimer interface [polypeptide binding]; other site 297245007954 active site 297245007955 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 297245007956 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 297245007957 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 297245007958 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 297245007959 dimer interface [polypeptide binding]; other site 297245007960 active site residues [active] 297245007961 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 297245007962 FlxA-like protein; Region: FlxA; pfam14282 297245007963 Spc24 subunit of Ndc80; Region: Spc24; pfam08286 297245007964 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245007965 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245007966 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 297245007967 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 297245007968 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 297245007969 ligand binding site [chemical binding]; other site 297245007970 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 297245007971 active site 297245007972 substrate binding pocket [chemical binding]; other site 297245007973 dimer interface [polypeptide binding]; other site 297245007974 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 297245007975 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 297245007976 dimer interface [polypeptide binding]; other site 297245007977 catalytic site [active] 297245007978 putative active site [active] 297245007979 putative substrate binding site [chemical binding]; other site 297245007980 peroxidase; Provisional; Region: PRK15000 297245007981 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 297245007982 dimer interface [polypeptide binding]; other site 297245007983 decamer (pentamer of dimers) interface [polypeptide binding]; other site 297245007984 catalytic triad [active] 297245007985 peroxidatic and resolving cysteines [active] 297245007986 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 297245007987 putative GSH binding site [chemical binding]; other site 297245007988 catalytic residues [active] 297245007989 superoxide dismutase; Provisional; Region: PRK10543 297245007990 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 297245007991 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 297245007992 acetylornithine aminotransferase; Provisional; Region: PRK02627 297245007993 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 297245007994 inhibitor-cofactor binding pocket; inhibition site 297245007995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 297245007996 catalytic residue [active] 297245007997 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 297245007998 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 297245007999 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 297245008000 active site 297245008001 catalytic site [active] 297245008002 malate dehydrogenase; Provisional; Region: PRK13529 297245008003 Malic enzyme, N-terminal domain; Region: malic; pfam00390 297245008004 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 297245008005 NAD(P) binding site [chemical binding]; other site 297245008006 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 297245008007 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 297245008008 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 297245008009 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 297245008010 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 297245008011 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 297245008012 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 297245008013 active site 297245008014 Zn binding site [ion binding]; other site 297245008015 Rossmann-like domain; Region: Rossmann-like; pfam10727 297245008016 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 297245008017 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 297245008018 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 297245008019 CAP-like domain; other site 297245008020 active site 297245008021 primary dimer interface [polypeptide binding]; other site 297245008022 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 297245008023 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 297245008024 gamma subunit interface [polypeptide binding]; other site 297245008025 LBP interface [polypeptide binding]; other site 297245008026 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 297245008027 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 297245008028 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 297245008029 alpha subunit interaction interface [polypeptide binding]; other site 297245008030 Walker A motif; other site 297245008031 ATP binding site [chemical binding]; other site 297245008032 Walker B motif; other site 297245008033 inhibitor binding site; inhibition site 297245008034 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 297245008035 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 297245008036 core domain interface [polypeptide binding]; other site 297245008037 delta subunit interface [polypeptide binding]; other site 297245008038 epsilon subunit interface [polypeptide binding]; other site 297245008039 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 297245008040 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 297245008041 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 297245008042 beta subunit interaction interface [polypeptide binding]; other site 297245008043 Walker A motif; other site 297245008044 ATP binding site [chemical binding]; other site 297245008045 Walker B motif; other site 297245008046 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 297245008047 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 297245008048 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 297245008049 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 297245008050 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 297245008051 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 297245008052 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 297245008053 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 297245008054 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 297245008055 outer membrane lipoprotein; Provisional; Region: PRK11023 297245008056 BON domain; Region: BON; pfam04972 297245008057 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 297245008058 BON domain; Region: BON; pfam04972 297245008059 BON domain; Region: BON; cl02771 297245008060 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 297245008061 dimer interface [polypeptide binding]; other site 297245008062 active site 297245008063 similar to conserved hypothetical protein;hypothetical protein 297245008064 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 297245008065 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 297245008066 putative ligand binding site [chemical binding]; other site 297245008067 Predicted methyltransferases [General function prediction only]; Region: COG0313 297245008068 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 297245008069 putative SAM binding site [chemical binding]; other site 297245008070 putative homodimer interface [polypeptide binding]; other site 297245008071 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 297245008072 Fatty acid desaturase; Region: FA_desaturase; pfam00487 297245008073 Di-iron ligands [ion binding]; other site 297245008074 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 297245008075 Sulfate transporter family; Region: Sulfate_transp; pfam00916 297245008076 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 297245008077 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 297245008078 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 297245008079 ligand binding site [chemical binding]; other site 297245008080 flexible hinge region; other site 297245008081 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 297245008082 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 297245008083 active site 297245008084 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 297245008085 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 297245008086 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 297245008087 GTP/Mg2+ binding site [chemical binding]; other site 297245008088 G4 box; other site 297245008089 G5 box; other site 297245008090 trmE is a tRNA modification GTPase; Region: trmE; cd04164 297245008091 G1 box; other site 297245008092 G1 box; other site 297245008093 GTP/Mg2+ binding site [chemical binding]; other site 297245008094 Switch I region; other site 297245008095 Switch I region; other site 297245008096 G2 box; other site 297245008097 G2 box; other site 297245008098 Switch II region; other site 297245008099 G3 box; other site 297245008100 G4 box; other site 297245008101 G5 box; other site 297245008102 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 297245008103 membrane protein insertase; Provisional; Region: PRK01318 297245008104 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 297245008105 hypothetical protein; Provisional; Region: PRK14380 297245008106 Ribonuclease P; Region: Ribonuclease_P; cl00457 297245008107 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399