-- dump date   	20140619_130345
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
91891000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
91891000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
91891000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891000004	Walker A motif; other site
91891000005	ATP binding site [chemical binding]; other site
91891000006	Walker B motif; other site
91891000007	arginine finger; other site
91891000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
91891000009	DnaA box-binding interface [nucleotide binding]; other site
91891000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
91891000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
91891000012	putative DNA binding surface [nucleotide binding]; other site
91891000013	dimer interface [polypeptide binding]; other site
91891000014	beta-clamp/clamp loader binding surface; other site
91891000015	beta-clamp/translesion DNA polymerase binding surface; other site
91891000016	recombination protein F; Reviewed; Region: recF; PRK00064
91891000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891000018	Walker A/P-loop; other site
91891000019	ATP binding site [chemical binding]; other site
91891000020	Q-loop/lid; other site
91891000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891000022	ABC transporter signature motif; other site
91891000023	Walker B; other site
91891000024	D-loop; other site
91891000025	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
91891000026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891000027	Mg2+ binding site [ion binding]; other site
91891000028	G-X-G motif; other site
91891000029	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
91891000030	anchoring element; other site
91891000031	dimer interface [polypeptide binding]; other site
91891000032	ATP binding site [chemical binding]; other site
91891000033	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
91891000034	active site
91891000035	putative metal-binding site [ion binding]; other site
91891000036	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
91891000037	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
91891000038	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
91891000039	arginine decarboxylase; Provisional; Region: PRK05354
91891000040	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
91891000041	dimer interface [polypeptide binding]; other site
91891000042	active site
91891000043	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
91891000044	catalytic residues [active]
91891000045	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
91891000046	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
91891000047	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
91891000048	putative active site; other site
91891000049	catalytic triad [active]
91891000050	putative dimer interface [polypeptide binding]; other site
91891000051	bacterial Hfq-like; Region: Hfq; cd01716
91891000052	hexamer interface [polypeptide binding]; other site
91891000053	Sm1 motif; other site
91891000054	RNA binding site [nucleotide binding]; other site
91891000055	Sm2 motif; other site
91891000056	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
91891000057	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
91891000058	HflX GTPase family; Region: HflX; cd01878
91891000059	G1 box; other site
91891000060	GTP/Mg2+ binding site [chemical binding]; other site
91891000061	Switch I region; other site
91891000062	G2 box; other site
91891000063	G3 box; other site
91891000064	Switch II region; other site
91891000065	G4 box; other site
91891000066	G5 box; other site
91891000067	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
91891000068	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
91891000069	catalytic residues [active]
91891000070	Pirin; Region: Pirin; pfam02678
91891000071	Pirin-related protein [General function prediction only]; Region: COG1741
91891000072	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
91891000073	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
91891000074	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
91891000075	active site
91891000076	nucleophile elbow; other site
91891000077	Patatin phospholipase; Region: DUF3734; pfam12536
91891000078	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
91891000079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891000080	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891000081	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
91891000082	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
91891000083	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
91891000084	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
91891000085	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
91891000086	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
91891000087	active site
91891000088	Zn binding site [ion binding]; other site
91891000089	hypothetical protein; Provisional; Region: PRK05255
91891000090	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
91891000091	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
91891000092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891000093	Methyltransferase domain; Region: Methyltransf_26; pfam13659
91891000094	Protein of unknown function (DUF962); Region: DUF962; cl01879
91891000095	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
91891000096	amino acid transporter; Region: 2A0306; TIGR00909
91891000097	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
91891000098	Phosphate transporter family; Region: PHO4; pfam01384
91891000099	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
91891000100	diiron binding motif [ion binding]; other site
91891000101	PAS domain; Region: PAS_9; pfam13426
91891000102	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891000103	putative active site [active]
91891000104	heme pocket [chemical binding]; other site
91891000105	PAS domain S-box; Region: sensory_box; TIGR00229
91891000106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891000107	putative active site [active]
91891000108	heme pocket [chemical binding]; other site
91891000109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891000110	PAS domain; Region: PAS_9; pfam13426
91891000111	putative active site [active]
91891000112	heme pocket [chemical binding]; other site
91891000113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891000114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891000115	metal binding site [ion binding]; metal-binding site
91891000116	active site
91891000117	I-site; other site
91891000118	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891000119	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
91891000120	Peptidase family M28; Region: Peptidase_M28; pfam04389
91891000121	active site
91891000122	metal binding site [ion binding]; metal-binding site
91891000123	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891000124	putative active site [active]
91891000125	GIY-YIG motif/motif A; other site
91891000126	putative metal binding site [ion binding]; other site
91891000127	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
91891000128	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891000129	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891000130	substrate binding pocket [chemical binding]; other site
91891000131	membrane-bound complex binding site; other site
91891000132	hinge residues; other site
91891000133	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891000134	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891000135	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
91891000136	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891000137	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
91891000138	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
91891000139	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
91891000140	trimer interface [polypeptide binding]; other site
91891000141	active site
91891000142	substrate binding site [chemical binding]; other site
91891000143	CoA binding site [chemical binding]; other site
91891000144	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
91891000145	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
91891000146	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
91891000147	Predicted membrane protein [Function unknown]; Region: COG2323
91891000148	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891000149	putative active site [active]
91891000150	GIY-YIG motif/motif A; other site
91891000151	putative metal binding site [ion binding]; other site
91891000152	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
91891000153	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
91891000154	tetramer interface [polypeptide binding]; other site
91891000155	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
91891000156	active site
91891000157	Mg2+/Mn2+ binding site [ion binding]; other site
91891000158	Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981
91891000159	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891000160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891000161	LysR substrate binding domain; Region: LysR_substrate; pfam03466
91891000162	dimerization interface [polypeptide binding]; other site
91891000163	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
91891000164	putative active site [active]
91891000165	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
91891000166	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
91891000167	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
91891000168	DNA binding residues [nucleotide binding]
91891000169	dimer interface [polypeptide binding]; other site
91891000170	mercury binding site [ion binding]; other site
91891000171	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
91891000172	Predicted membrane protein [Function unknown]; Region: COG3428
91891000173	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891000174	HipA N-terminal domain; Region: couple_hipA; TIGR03071
91891000175	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
91891000176	HipA-like N-terminal domain; Region: HipA_N; pfam07805
91891000177	HipA-like C-terminal domain; Region: HipA_C; pfam07804
91891000178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891000179	non-specific DNA binding site [nucleotide binding]; other site
91891000180	salt bridge; other site
91891000181	sequence-specific DNA binding site [nucleotide binding]; other site
91891000182	Evidence 2b : Function of strongly homologous gene
91891000183	Evidence 2b : Function of strongly homologous gene
91891000184	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
91891000185	aspartate aminotransferase; Provisional; Region: PRK05764
91891000186	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
91891000187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891000188	homodimer interface [polypeptide binding]; other site
91891000189	catalytic residue [active]
91891000190	excinuclease ABC subunit B; Provisional; Region: PRK05298
91891000191	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891000192	ATP binding site [chemical binding]; other site
91891000193	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891000194	nucleotide binding region [chemical binding]; other site
91891000195	ATP-binding site [chemical binding]; other site
91891000196	Ultra-violet resistance protein B; Region: UvrB; pfam12344
91891000197	UvrB/uvrC motif; Region: UVR; pfam02151
91891000198	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891000199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891000200	metal binding site [ion binding]; metal-binding site
91891000201	active site
91891000202	I-site; other site
91891000203	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891000204	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
91891000205	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
91891000206	active site
91891000207	FMN binding site [chemical binding]; other site
91891000208	substrate binding site [chemical binding]; other site
91891000209	3Fe-4S cluster binding site [ion binding]; other site
91891000210	Cell division protein ZapA; Region: ZapA; pfam05164
91891000211	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
91891000212	proline aminopeptidase P II; Provisional; Region: PRK10879
91891000213	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
91891000214	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
91891000215	active site
91891000216	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
91891000217	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
91891000218	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
91891000219	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
91891000220	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
91891000221	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
91891000222	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
91891000223	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
91891000224	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
91891000225	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
91891000226	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891000227	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891000228	substrate binding pocket [chemical binding]; other site
91891000229	membrane-bound complex binding site; other site
91891000230	hinge residues; other site
91891000231	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
91891000232	ribonuclease R; Region: RNase_R; TIGR02063
91891000233	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
91891000234	RNB domain; Region: RNB; pfam00773
91891000235	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
91891000236	RNA binding site [nucleotide binding]; other site
91891000237	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
91891000238	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
91891000239	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
91891000240	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
91891000241	tetramer (dimer of dimers) interface [polypeptide binding]; other site
91891000242	active site
91891000243	dimer interface [polypeptide binding]; other site
91891000244	5' nucleotidase family; Region: 5_nucleotid; cl17687
91891000245	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
91891000246	Response regulator receiver domain; Region: Response_reg; pfam00072
91891000247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891000248	active site
91891000249	phosphorylation site [posttranslational modification]
91891000250	intermolecular recognition site; other site
91891000251	DNA polymerase I; Provisional; Region: PRK05755
91891000252	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
91891000253	active site
91891000254	metal binding site 1 [ion binding]; metal-binding site
91891000255	putative 5' ssDNA interaction site; other site
91891000256	metal binding site 3; metal-binding site
91891000257	metal binding site 2 [ion binding]; metal-binding site
91891000258	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
91891000259	putative DNA binding site [nucleotide binding]; other site
91891000260	putative metal binding site [ion binding]; other site
91891000261	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
91891000262	active site
91891000263	catalytic site [active]
91891000264	substrate binding site [chemical binding]; other site
91891000265	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
91891000266	active site
91891000267	DNA binding site [nucleotide binding]
91891000268	catalytic site [active]
91891000269	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
91891000270	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
91891000271	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
91891000272	trimer interface [polypeptide binding]; other site
91891000273	active site
91891000274	UDP-GlcNAc binding site [chemical binding]; other site
91891000275	lipid binding site [chemical binding]; lipid-binding site
91891000276	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891000277	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
91891000278	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
91891000279	dimer interface [polypeptide binding]; other site
91891000280	active site
91891000281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891000282	Coenzyme A binding pocket [chemical binding]; other site
91891000283	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
91891000284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891000285	Coenzyme A binding pocket [chemical binding]; other site
91891000286	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
91891000287	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
91891000288	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
91891000289	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
91891000290	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
91891000291	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
91891000292	substrate binding pocket [chemical binding]; other site
91891000293	substrate-Mg2+ binding site; other site
91891000294	aspartate-rich region 1; other site
91891000295	aspartate-rich region 2; other site
91891000296	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
91891000297	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891000298	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
91891000299	tetramer interface [polypeptide binding]; other site
91891000300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891000301	catalytic residue [active]
91891000302	YCII-related domain; Region: YCII; cl00999
91891000303	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
91891000304	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
91891000305	tetramer interface [polypeptide binding]; other site
91891000306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891000307	catalytic residue [active]
91891000308	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
91891000309	lipoyl attachment site [posttranslational modification]; other site
91891000310	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
91891000311	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
91891000312	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
91891000313	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891000314	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
91891000315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891000316	dimer interface [polypeptide binding]; other site
91891000317	conserved gate region; other site
91891000318	putative PBP binding loops; other site
91891000319	ABC-ATPase subunit interface; other site
91891000320	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
91891000321	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
91891000322	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
91891000323	Walker A/P-loop; other site
91891000324	ATP binding site [chemical binding]; other site
91891000325	Q-loop/lid; other site
91891000326	ABC transporter signature motif; other site
91891000327	Walker B; other site
91891000328	D-loop; other site
91891000329	H-loop/switch region; other site
91891000330	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
91891000331	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
91891000332	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
91891000333	catalytic residues [active]
91891000334	hinge region; other site
91891000335	alpha helical domain; other site
91891000336	Cytochrome c553 [Energy production and conversion]; Region: COG2863
91891000337	Cytochrome c; Region: Cytochrom_C; cl11414
91891000338	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
91891000339	G1 box; other site
91891000340	GTP/Mg2+ binding site [chemical binding]; other site
91891000341	Switch I region; other site
91891000342	G2 box; other site
91891000343	G3 box; other site
91891000344	Switch II region; other site
91891000345	G4 box; other site
91891000346	G5 box; other site
91891000347	acetyl-CoA synthetase; Provisional; Region: PRK00174
91891000348	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
91891000349	active site
91891000350	CoA binding site [chemical binding]; other site
91891000351	acyl-activating enzyme (AAE) consensus motif; other site
91891000352	AMP binding site [chemical binding]; other site
91891000353	acetate binding site [chemical binding]; other site
91891000354	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
91891000355	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
91891000356	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
91891000357	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
91891000358	tetrameric interface [polypeptide binding]; other site
91891000359	NAD binding site [chemical binding]; other site
91891000360	catalytic residues [active]
91891000361	Dodecin; Region: Dodecin; cl01328
91891000362	dihydrodipicolinate reductase; Provisional; Region: PRK00048
91891000363	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
91891000364	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
91891000365	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891000366	putative active site [active]
91891000367	GIY-YIG motif/motif A; other site
91891000368	putative metal binding site [ion binding]; other site
91891000369	ProQ/FINO family; Region: ProQ; pfam04352
91891000370	putative RNA binding sites [nucleotide binding]; other site
91891000371	MltA specific insert domain; Region: MltA; cl08398
91891000372	pyruvate kinase; Provisional; Region: PRK05826
91891000373	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
91891000374	domain interfaces; other site
91891000375	active site
91891000376	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
91891000377	Phosphoglycerate kinase; Region: PGK; pfam00162
91891000378	substrate binding site [chemical binding]; other site
91891000379	hinge regions; other site
91891000380	ADP binding site [chemical binding]; other site
91891000381	catalytic site [active]
91891000382	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
91891000383	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
91891000384	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
91891000385	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
91891000386	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
91891000387	TPP-binding site [chemical binding]; other site
91891000388	dimer interface [polypeptide binding]; other site
91891000389	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
91891000390	PYR/PP interface [polypeptide binding]; other site
91891000391	dimer interface [polypeptide binding]; other site
91891000392	TPP binding site [chemical binding]; other site
91891000393	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
91891000394	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
91891000395	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
91891000396	active site
91891000397	Zn binding site [ion binding]; other site
91891000398	integrase; Provisional; Region: PRK09692
91891000399	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
91891000400	active site
91891000401	Int/Topo IB signature motif; other site
91891000402	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
91891000403	AAA domain; Region: AAA_25; pfam13481
91891000404	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891000405	Walker A motif; other site
91891000406	ATP binding site [chemical binding]; other site
91891000407	Walker B motif; other site
91891000408	Homeodomain-like domain; Region: HTH_23; pfam13384
91891000409	Homeodomain-like domain; Region: HTH_23; cl17451
91891000410	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
91891000411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891000412	non-specific DNA binding site [nucleotide binding]; other site
91891000413	salt bridge; other site
91891000414	sequence-specific DNA binding site [nucleotide binding]; other site
91891000415	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
91891000416	DNA methylase; Region: N6_N4_Mtase; pfam01555
91891000417	DNA methylase; Region: N6_N4_Mtase; pfam01555
91891000418	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
91891000419	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
91891000420	BRO family, N-terminal domain; Region: Bro-N; pfam02498
91891000421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891000422	Walker A motif; other site
91891000423	ATP binding site [chemical binding]; other site
91891000424	Walker B motif; other site
91891000425	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
91891000426	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891000427	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
91891000428	Evidence 4 : Homologs of previously reported genes of unknown function
91891000429	Evidence 4 : Homologs of previously reported genes of unknown function
91891000430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891000431	Coenzyme A binding pocket [chemical binding]; other site
91891000432	PAS domain; Region: PAS_9; pfam13426
91891000433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891000434	putative active site [active]
91891000435	heme pocket [chemical binding]; other site
91891000436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891000437	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891000438	metal binding site [ion binding]; metal-binding site
91891000439	active site
91891000440	I-site; other site
91891000441	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891000442	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
91891000443	active site
91891000444	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
91891000445	Uncharacterized conserved protein [Function unknown]; Region: COG0432
91891000446	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
91891000447	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
91891000448	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
91891000449	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
91891000450	Protein of unknown function (DUF808); Region: DUF808; pfam05661
91891000451	RF-1 domain; Region: RF-1; pfam00472
91891000452	Protein of unknown function (DUF330); Region: DUF330; pfam03886
91891000453	mce related protein; Region: MCE; pfam02470
91891000454	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
91891000455	Permease; Region: Permease; pfam02405
91891000456	F-box-like; Region: F-box-like; pfam12937
91891000457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891000458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891000459	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
91891000460	dimerization interface [polypeptide binding]; other site
91891000461	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
91891000462	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
91891000463	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
91891000464	substrate binding pocket [chemical binding]; other site
91891000465	active site
91891000466	iron coordination sites [ion binding]; other site
91891000467	hypothetical protein; Provisional; Region: PRK07190
91891000468	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
91891000469	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
91891000470	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
91891000471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891000472	putative substrate translocation pore; other site
91891000473	hypothetical protein; Provisional; Region: PRK07206
91891000474	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
91891000475	Methyltransferase domain; Region: Methyltransf_31; pfam13847
91891000476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891000477	S-adenosylmethionine binding site [chemical binding]; other site
91891000478	M48 family peptidase; Provisional; Region: PRK03001
91891000479	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
91891000480	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
91891000481	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891000482	putative active site [active]
91891000483	GIY-YIG motif/motif A; other site
91891000484	putative metal binding site [ion binding]; other site
91891000485	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
91891000486	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
91891000487	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
91891000488	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
91891000489	Walker A/P-loop; other site
91891000490	ATP binding site [chemical binding]; other site
91891000491	Q-loop/lid; other site
91891000492	ABC transporter signature motif; other site
91891000493	Walker B; other site
91891000494	D-loop; other site
91891000495	H-loop/switch region; other site
91891000496	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
91891000497	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
91891000498	TM-ABC transporter signature motif; other site
91891000499	hypothetical protein; Provisional; Region: PRK09133
91891000500	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
91891000501	putative metal binding site [ion binding]; other site
91891000502	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
91891000503	CoA-transferase family III; Region: CoA_transf_3; pfam02515
91891000504	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
91891000505	dimer interface [polypeptide binding]; other site
91891000506	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
91891000507	active site
91891000508	heme binding site [chemical binding]; other site
91891000509	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
91891000510	Uncharacterized conserved protein [Function unknown]; Region: COG0393
91891000511	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
91891000512	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
91891000513	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
91891000514	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
91891000515	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
91891000516	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
91891000517	DAK2 domain; Region: Dak2; pfam02734
91891000518	EDD domain protein, DegV family; Region: DegV; TIGR00762
91891000519	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
91891000520	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
91891000521	classical (c) SDRs; Region: SDR_c; cd05233
91891000522	NAD(P) binding site [chemical binding]; other site
91891000523	active site
91891000524	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
91891000525	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
91891000526	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
91891000527	Catalytic domain of Protein Kinases; Region: PKc; cd00180
91891000528	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
91891000529	active site
91891000530	ATP binding site [chemical binding]; other site
91891000531	substrate binding site [chemical binding]; other site
91891000532	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
91891000533	substrate binding site [chemical binding]; other site
91891000534	activation loop (A-loop); other site
91891000535	activation loop (A-loop); other site
91891000536	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
91891000537	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
91891000538	DNA photolyase; Region: DNA_photolyase; pfam00875
91891000539	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
91891000540	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
91891000541	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891000542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891000543	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
91891000544	putative dimerization interface [polypeptide binding]; other site
91891000545	Domain of unknown function (DUF329); Region: DUF329; pfam03884
91891000546	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
91891000547	ATP-grasp domain; Region: ATP-grasp; pfam02222
91891000548	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
91891000549	Nitrogen regulatory protein P-II; Region: P-II; cl00412
91891000550	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
91891000551	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
91891000552	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
91891000553	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891000554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891000555	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
91891000556	dimerization interface [polypeptide binding]; other site
91891000557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891000558	ATP binding site [chemical binding]; other site
91891000559	Q-loop/lid; other site
91891000560	ABC transporter signature motif; other site
91891000561	Walker B; other site
91891000562	D-loop; other site
91891000563	H-loop/switch region; other site
91891000564	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
91891000565	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891000566	Outer membrane efflux protein; Region: OEP; pfam02321
91891000567	Outer membrane efflux protein; Region: OEP; pfam02321
91891000568	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891000569	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
91891000570	hypothetical protein; Provisional; Region: PHA02764
91891000571	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
91891000572	heme ligand [chemical binding]; other site
91891000573	CHASE3 domain; Region: CHASE3; pfam05227
91891000574	PAS domain S-box; Region: sensory_box; TIGR00229
91891000575	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
91891000576	GAF domain; Region: GAF_3; pfam13492
91891000577	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891000578	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891000579	metal binding site [ion binding]; metal-binding site
91891000580	active site
91891000581	I-site; other site
91891000582	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
91891000583	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891000584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891000585	motif II; other site
91891000586	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
91891000587	metal binding site 2 [ion binding]; metal-binding site
91891000588	putative DNA binding helix; other site
91891000589	metal binding site 1 [ion binding]; metal-binding site
91891000590	dimer interface [polypeptide binding]; other site
91891000591	structural Zn2+ binding site [ion binding]; other site
91891000592	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
91891000593	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
91891000594	PYR/PP interface [polypeptide binding]; other site
91891000595	dimer interface [polypeptide binding]; other site
91891000596	TPP binding site [chemical binding]; other site
91891000597	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
91891000598	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
91891000599	TPP-binding site [chemical binding]; other site
91891000600	dimer interface [polypeptide binding]; other site
91891000601	Dot/Icm substrate protein; Region: SidE; pfam12252
91891000602	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
91891000603	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
91891000604	TAP-like protein; Region: Abhydrolase_4; pfam08386
91891000605	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
91891000606	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
91891000607	tetramerization interface [polypeptide binding]; other site
91891000608	NAD(P) binding site [chemical binding]; other site
91891000609	catalytic residues [active]
91891000610	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
91891000611	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
91891000612	inhibitor-cofactor binding pocket; inhibition site
91891000613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891000614	catalytic residue [active]
91891000615	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
91891000616	glutaminase A; Region: Gln_ase; TIGR03814
91891000617	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
91891000618	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
91891000619	NAD binding site [chemical binding]; other site
91891000620	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
91891000621	putative NAD(P) binding site [chemical binding]; other site
91891000622	homodimer interface [polypeptide binding]; other site
91891000623	mercuric reductase; Validated; Region: PRK06370
91891000624	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
91891000625	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
91891000626	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
91891000627	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
91891000628	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
91891000629	ArsC family; Region: ArsC; pfam03960
91891000630	catalytic residues [active]
91891000631	Fatty acid desaturase; Region: FA_desaturase; pfam00487
91891000632	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
91891000633	Di-iron ligands [ion binding]; other site
91891000634	Transposase; Region: DDE_Tnp_ISL3; pfam01610
91891000635	helicase 45; Provisional; Region: PTZ00424
91891000636	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
91891000637	ATP binding site [chemical binding]; other site
91891000638	Mg++ binding site [ion binding]; other site
91891000639	motif III; other site
91891000640	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891000641	nucleotide binding region [chemical binding]; other site
91891000642	ATP-binding site [chemical binding]; other site
91891000643	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
91891000644	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
91891000645	hypothetical protein; Provisional; Region: PRK11212
91891000646	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
91891000647	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
91891000648	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
91891000649	HlyD family secretion protein; Region: HlyD; pfam00529
91891000650	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891000651	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891000652	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891000653	GIY-YIG motif/motif A; other site
91891000654	putative active site [active]
91891000655	putative metal binding site [ion binding]; other site
91891000656	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
91891000657	Fe-S cluster binding site [ion binding]; other site
91891000658	active site
91891000659	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
91891000660	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
91891000661	amidase catalytic site [active]
91891000662	Zn binding residues [ion binding]; other site
91891000663	substrate binding site [chemical binding]; other site
91891000664	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
91891000665	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
91891000666	Multicopper oxidase; Region: Cu-oxidase; pfam00394
91891000667	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
91891000668	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
91891000669	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
91891000670	oligomer interface [polypeptide binding]; other site
91891000671	metal binding site [ion binding]; metal-binding site
91891000672	metal binding site [ion binding]; metal-binding site
91891000673	putative Cl binding site [ion binding]; other site
91891000674	aspartate ring; other site
91891000675	hydrophobic gate; other site
91891000676	basic sphincter; other site
91891000677	periplasmic entrance; other site
91891000678	HD domain; Region: HD_3; pfam13023
91891000679	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
91891000680	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
91891000681	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
91891000682	active site
91891000683	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
91891000684	Isochorismatase family; Region: Isochorismatase; pfam00857
91891000685	catalytic triad [active]
91891000686	metal binding site [ion binding]; metal-binding site
91891000687	conserved cis-peptide bond; other site
91891000688	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
91891000689	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891000690	metal binding site [ion binding]; metal-binding site
91891000691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891000692	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
91891000693	putative substrate translocation pore; other site
91891000694	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891000695	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891000696	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
91891000697	putative effector binding pocket; other site
91891000698	dimerization interface [polypeptide binding]; other site
91891000699	Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485
91891000700	Ras interaction site [polypeptide binding]; other site
91891000701	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
91891000702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891000703	active site
91891000704	phosphorylation site [posttranslational modification]
91891000705	intermolecular recognition site; other site
91891000706	dimerization interface [polypeptide binding]; other site
91891000707	PAS domain; Region: PAS; smart00091
91891000708	PAS fold; Region: PAS_7; pfam12860
91891000709	putative active site [active]
91891000710	heme pocket [chemical binding]; other site
91891000711	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891000712	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891000713	metal binding site [ion binding]; metal-binding site
91891000714	active site
91891000715	I-site; other site
91891000716	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891000717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891000718	PAS fold; Region: PAS_3; pfam08447
91891000719	putative active site [active]
91891000720	heme pocket [chemical binding]; other site
91891000721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891000722	ATP binding site [chemical binding]; other site
91891000723	Mg2+ binding site [ion binding]; other site
91891000724	G-X-G motif; other site
91891000725	FIST N domain; Region: FIST; pfam08495
91891000726	Uncharacterized conserved protein [Function unknown]; Region: COG3287
91891000727	FIST C domain; Region: FIST_C; pfam10442
91891000728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891000729	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
91891000730	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
91891000731	dimerization interface [polypeptide binding]; other site
91891000732	amino acid transporter; Region: 2A0306; TIGR00909
91891000733	Putative methyltransferase; Region: Methyltransf_4; cl17290
91891000734	hypothetical protein; Provisional; Region: PRK08317
91891000735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891000736	S-adenosylmethionine binding site [chemical binding]; other site
91891000737	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891000738	GIY-YIG motif/motif A; other site
91891000739	putative active site [active]
91891000740	putative metal binding site [ion binding]; other site
91891000741	formate dehydrogenase; Provisional; Region: PRK07574
91891000742	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
91891000743	dimerization interface [polypeptide binding]; other site
91891000744	ligand binding site [chemical binding]; other site
91891000745	NAD binding site [chemical binding]; other site
91891000746	catalytic site [active]
91891000747	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
91891000748	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
91891000749	putative NAD(P) binding site [chemical binding]; other site
91891000750	homodimer interface [polypeptide binding]; other site
91891000751	homotetramer interface [polypeptide binding]; other site
91891000752	active site
91891000753	elongation factor P; Validated; Region: PRK00529
91891000754	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
91891000755	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
91891000756	RNA binding site [nucleotide binding]; other site
91891000757	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
91891000758	RNA binding site [nucleotide binding]; other site
91891000759	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
91891000760	Radical SAM superfamily; Region: Radical_SAM; pfam04055
91891000761	FeS/SAM binding site; other site
91891000762	polyphosphate kinase; Provisional; Region: PRK05443
91891000763	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
91891000764	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
91891000765	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
91891000766	putative active site [active]
91891000767	catalytic site [active]
91891000768	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
91891000769	putative domain interface [polypeptide binding]; other site
91891000770	putative active site [active]
91891000771	catalytic site [active]
91891000772	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
91891000773	nucleophile elbow; other site
91891000774	Chromate transporter; Region: Chromate_transp; pfam02417
91891000775	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
91891000776	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
91891000777	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
91891000778	active site
91891000779	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
91891000780	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
91891000781	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
91891000782	Substrate binding site; other site
91891000783	metal-binding site
91891000784	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
91891000785	Phosphotransferase enzyme family; Region: APH; pfam01636
91891000786	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
91891000787	OstA-like protein; Region: OstA; cl00844
91891000788	Organic solvent tolerance protein; Region: OstA_C; pfam04453
91891000789	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
91891000790	SurA N-terminal domain; Region: SurA_N; pfam09312
91891000791	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
91891000792	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
91891000793	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
91891000794	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
91891000795	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
91891000796	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
91891000797	folate binding site [chemical binding]; other site
91891000798	NADP+ binding site [chemical binding]; other site
91891000799	Repeats found in Drosophila proteins; Region: DM9; smart00696
91891000800	Protein of unknown function (DUF3421); Region: DUF3421; pfam11901
91891000801	Repeats found in Drosophila proteins; Region: DM9; smart00696
91891000802	elongation factor Tu; Reviewed; Region: PRK00049
91891000803	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
91891000804	G1 box; other site
91891000805	GEF interaction site [polypeptide binding]; other site
91891000806	GTP/Mg2+ binding site [chemical binding]; other site
91891000807	Switch I region; other site
91891000808	G2 box; other site
91891000809	G3 box; other site
91891000810	Switch II region; other site
91891000811	G4 box; other site
91891000812	G5 box; other site
91891000813	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
91891000814	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
91891000815	Antibiotic Binding Site [chemical binding]; other site
91891000816	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
91891000817	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
91891000818	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
91891000819	putative homodimer interface [polypeptide binding]; other site
91891000820	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
91891000821	heterodimer interface [polypeptide binding]; other site
91891000822	homodimer interface [polypeptide binding]; other site
91891000823	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
91891000824	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
91891000825	23S rRNA interface [nucleotide binding]; other site
91891000826	L7/L12 interface [polypeptide binding]; other site
91891000827	putative thiostrepton binding site; other site
91891000828	L25 interface [polypeptide binding]; other site
91891000829	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
91891000830	mRNA/rRNA interface [nucleotide binding]; other site
91891000831	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
91891000832	23S rRNA interface [nucleotide binding]; other site
91891000833	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
91891000834	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
91891000835	peripheral dimer interface [polypeptide binding]; other site
91891000836	core dimer interface [polypeptide binding]; other site
91891000837	L10 interface [polypeptide binding]; other site
91891000838	L11 interface [polypeptide binding]; other site
91891000839	putative EF-Tu interaction site [polypeptide binding]; other site
91891000840	putative EF-G interaction site [polypeptide binding]; other site
91891000841	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
91891000842	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
91891000843	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
91891000844	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
91891000845	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
91891000846	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
91891000847	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
91891000848	RPB3 interaction site [polypeptide binding]; other site
91891000849	RPB1 interaction site [polypeptide binding]; other site
91891000850	RPB11 interaction site [polypeptide binding]; other site
91891000851	RPB10 interaction site [polypeptide binding]; other site
91891000852	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
91891000853	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
91891000854	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
91891000855	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
91891000856	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
91891000857	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
91891000858	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
91891000859	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
91891000860	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
91891000861	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
91891000862	DNA binding site [nucleotide binding]
91891000863	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
91891000864	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
91891000865	S17 interaction site [polypeptide binding]; other site
91891000866	S8 interaction site; other site
91891000867	16S rRNA interaction site [nucleotide binding]; other site
91891000868	streptomycin interaction site [chemical binding]; other site
91891000869	23S rRNA interaction site [nucleotide binding]; other site
91891000870	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
91891000871	30S ribosomal protein S7; Validated; Region: PRK05302
91891000872	elongation factor G; Reviewed; Region: PRK00007
91891000873	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
91891000874	G1 box; other site
91891000875	putative GEF interaction site [polypeptide binding]; other site
91891000876	GTP/Mg2+ binding site [chemical binding]; other site
91891000877	Switch I region; other site
91891000878	G2 box; other site
91891000879	G3 box; other site
91891000880	Switch II region; other site
91891000881	G4 box; other site
91891000882	G5 box; other site
91891000883	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
91891000884	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
91891000885	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
91891000886	elongation factor Tu; Reviewed; Region: PRK00049
91891000887	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
91891000888	G1 box; other site
91891000889	GEF interaction site [polypeptide binding]; other site
91891000890	GTP/Mg2+ binding site [chemical binding]; other site
91891000891	Switch I region; other site
91891000892	G2 box; other site
91891000893	G3 box; other site
91891000894	Switch II region; other site
91891000895	G4 box; other site
91891000896	G5 box; other site
91891000897	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
91891000898	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
91891000899	Antibiotic Binding Site [chemical binding]; other site
91891000900	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
91891000901	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
91891000902	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
91891000903	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
91891000904	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
91891000905	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
91891000906	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
91891000907	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
91891000908	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
91891000909	putative translocon binding site; other site
91891000910	protein-rRNA interface [nucleotide binding]; other site
91891000911	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
91891000912	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
91891000913	G-X-X-G motif; other site
91891000914	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
91891000915	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
91891000916	23S rRNA interface [nucleotide binding]; other site
91891000917	5S rRNA interface [nucleotide binding]; other site
91891000918	putative antibiotic binding site [chemical binding]; other site
91891000919	L25 interface [polypeptide binding]; other site
91891000920	L27 interface [polypeptide binding]; other site
91891000921	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
91891000922	putative translocon interaction site; other site
91891000923	23S rRNA interface [nucleotide binding]; other site
91891000924	signal recognition particle (SRP54) interaction site; other site
91891000925	L23 interface [polypeptide binding]; other site
91891000926	trigger factor interaction site; other site
91891000927	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
91891000928	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
91891000929	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
91891000930	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
91891000931	RNA binding site [nucleotide binding]; other site
91891000932	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
91891000933	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
91891000934	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
91891000935	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
91891000936	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
91891000937	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
91891000938	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
91891000939	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
91891000940	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
91891000941	23S rRNA interface [nucleotide binding]; other site
91891000942	L21e interface [polypeptide binding]; other site
91891000943	5S rRNA interface [nucleotide binding]; other site
91891000944	L27 interface [polypeptide binding]; other site
91891000945	L5 interface [polypeptide binding]; other site
91891000946	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
91891000947	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
91891000948	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
91891000949	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
91891000950	23S rRNA binding site [nucleotide binding]; other site
91891000951	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
91891000952	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
91891000953	SecY translocase; Region: SecY; pfam00344
91891000954	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
91891000955	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
91891000956	30S ribosomal protein S13; Region: bact_S13; TIGR03631
91891000957	30S ribosomal protein S11; Validated; Region: PRK05309
91891000958	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
91891000959	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
91891000960	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
91891000961	RNA binding surface [nucleotide binding]; other site
91891000962	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
91891000963	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
91891000964	alphaNTD homodimer interface [polypeptide binding]; other site
91891000965	alphaNTD - beta interaction site [polypeptide binding]; other site
91891000966	alphaNTD - beta' interaction site [polypeptide binding]; other site
91891000967	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
91891000968	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
91891000969	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
91891000970	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
91891000971	dimer interface [polypeptide binding]; other site
91891000972	ssDNA binding site [nucleotide binding]; other site
91891000973	tetramer (dimer of dimers) interface [polypeptide binding]; other site
91891000974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891000975	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891000976	putative substrate translocation pore; other site
91891000977	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
91891000978	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
91891000979	putative NAD(P) binding site [chemical binding]; other site
91891000980	active site
91891000981	Phosphopantetheine attachment site; Region: PP-binding; cl09936
91891000982	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
91891000983	active site 2 [active]
91891000984	active site 1 [active]
91891000985	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
91891000986	active site 2 [active]
91891000987	dimer interface [polypeptide binding]; other site
91891000988	active site 1 [active]
91891000989	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
91891000990	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
91891000991	dimer interface [polypeptide binding]; other site
91891000992	active site
91891000993	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
91891000994	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
91891000995	active site
91891000996	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
91891000997	putative acyl-acceptor binding pocket; other site
91891000998	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
91891000999	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
91891001000	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
91891001001	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
91891001002	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
91891001003	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
91891001004	putative coenzyme Q binding site [chemical binding]; other site
91891001005	hypothetical protein; Validated; Region: PRK01777
91891001006	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
91891001007	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
91891001008	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
91891001009	metal binding site 2 [ion binding]; metal-binding site
91891001010	putative DNA binding helix; other site
91891001011	metal binding site 1 [ion binding]; metal-binding site
91891001012	dimer interface [polypeptide binding]; other site
91891001013	structural Zn2+ binding site [ion binding]; other site
91891001014	Evidence 7 : Gene remnant
91891001015	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891001016	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891001017	GIY-YIG motif/motif A; other site
91891001018	putative active site [active]
91891001019	putative metal binding site [ion binding]; other site
91891001020	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
91891001021	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
91891001022	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
91891001023	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
91891001024	ATP-grasp domain; Region: ATP-grasp_4; cl17255
91891001025	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
91891001026	CoenzymeA binding site [chemical binding]; other site
91891001027	subunit interaction site [polypeptide binding]; other site
91891001028	PHB binding site; other site
91891001029	BON domain; Region: BON; pfam04972
91891001030	BON domain; Region: BON; pfam04972
91891001031	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891001032	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
91891001033	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
91891001034	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
91891001035	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
91891001036	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
91891001037	heat shock protein HtpX; Provisional; Region: PRK02870
91891001038	inner membrane transport permease; Provisional; Region: PRK15066
91891001039	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
91891001040	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
91891001041	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891001042	Walker A/P-loop; other site
91891001043	ATP binding site [chemical binding]; other site
91891001044	Q-loop/lid; other site
91891001045	ABC transporter signature motif; other site
91891001046	Walker B; other site
91891001047	D-loop; other site
91891001048	H-loop/switch region; other site
91891001049	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
91891001050	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
91891001051	Protein of unknown function DUF45; Region: DUF45; pfam01863
91891001052	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891001053	putative active site [active]
91891001054	GIY-YIG motif/motif A; other site
91891001055	putative metal binding site [ion binding]; other site
91891001056	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
91891001057	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
91891001058	DNA binding site [nucleotide binding]
91891001059	active site
91891001060	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
91891001061	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
91891001062	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
91891001063	RimM N-terminal domain; Region: RimM; pfam01782
91891001064	PRC-barrel domain; Region: PRC; pfam05239
91891001065	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
91891001066	signal recognition particle protein; Provisional; Region: PRK10867
91891001067	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
91891001068	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
91891001069	P loop; other site
91891001070	GTP binding site [chemical binding]; other site
91891001071	Signal peptide binding domain; Region: SRP_SPB; pfam02978
91891001072	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891001073	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891001074	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891001075	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
91891001076	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
91891001077	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
91891001078	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
91891001079	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
91891001080	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
91891001081	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
91891001082	UbiA prenyltransferase family; Region: UbiA; pfam01040
91891001083	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
91891001084	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
91891001085	Cu(I) binding site [ion binding]; other site
91891001086	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
91891001087	RimK-like ATP-grasp domain; Region: RimK; pfam08443
91891001088	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
91891001089	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
91891001090	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
91891001091	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
91891001092	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
91891001093	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
91891001094	putative active site [active]
91891001095	phosphogluconate dehydratase; Validated; Region: PRK09054
91891001096	6-phosphogluconate dehydratase; Region: edd; TIGR01196
91891001097	Glucokinase; Region: Glucokinase; pfam02685
91891001098	glucokinase, proteobacterial type; Region: glk; TIGR00749
91891001099	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
91891001100	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
91891001101	active site
91891001102	intersubunit interface [polypeptide binding]; other site
91891001103	catalytic residue [active]
91891001104	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
91891001105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001106	putative substrate translocation pore; other site
91891001107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001108	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
91891001109	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891001110	salt bridge; other site
91891001111	non-specific DNA binding site [nucleotide binding]; other site
91891001112	sequence-specific DNA binding site [nucleotide binding]; other site
91891001113	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
91891001114	ferrochelatase; Reviewed; Region: hemH; PRK00035
91891001115	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
91891001116	C-terminal domain interface [polypeptide binding]; other site
91891001117	active site
91891001118	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
91891001119	active site
91891001120	N-terminal domain interface [polypeptide binding]; other site
91891001121	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
91891001122	DNA-binding site [nucleotide binding]; DNA binding site
91891001123	RNA-binding motif; other site
91891001124	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891001125	GIY-YIG motif/motif A; other site
91891001126	putative active site [active]
91891001127	putative metal binding site [ion binding]; other site
91891001128	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
91891001129	HIT family signature motif; other site
91891001130	catalytic residue [active]
91891001131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891001132	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
91891001133	active site
91891001134	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
91891001135	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
91891001136	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891001137	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891001138	Predicted membrane protein [Function unknown]; Region: COG1289
91891001139	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
91891001140	Predicted transcriptional regulators [Transcription]; Region: COG1733
91891001141	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
91891001142	Uncharacterized conserved protein [Function unknown]; Region: COG4278
91891001143	Methyltransferase domain; Region: Methyltransf_23; pfam13489
91891001144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891001145	S-adenosylmethionine binding site [chemical binding]; other site
91891001146	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891001147	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891001148	Protein of unknown function (DUF3773); Region: DUF3773; pfam12608
91891001149	Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; pfam09475
91891001150	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
91891001151	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
91891001152	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891001153	ligand binding site [chemical binding]; other site
91891001154	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891001155	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
91891001156	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
91891001157	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
91891001158	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
91891001159	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
91891001160	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
91891001161	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
91891001162	HNH nucleases; Region: HNHc; smart00507
91891001163	AAA-like domain; Region: AAA_10; pfam12846
91891001164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001165	metabolite-proton symporter; Region: 2A0106; TIGR00883
91891001166	putative substrate translocation pore; other site
91891001167	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
91891001168	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
91891001169	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
91891001170	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
91891001171	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
91891001172	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
91891001173	purine monophosphate binding site [chemical binding]; other site
91891001174	dimer interface [polypeptide binding]; other site
91891001175	putative catalytic residues [active]
91891001176	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
91891001177	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
91891001178	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
91891001179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891001180	S-adenosylmethionine binding site [chemical binding]; other site
91891001181	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
91891001182	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
91891001183	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
91891001184	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
91891001185	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
91891001186	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
91891001187	carboxyltransferase (CT) interaction site; other site
91891001188	biotinylation site [posttranslational modification]; other site
91891001189	Dehydroquinase class II; Region: DHquinase_II; pfam01220
91891001190	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
91891001191	trimer interface [polypeptide binding]; other site
91891001192	active site
91891001193	dimer interface [polypeptide binding]; other site
91891001194	pyruvate carboxylase subunit B; Provisional; Region: PRK14042
91891001195	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
91891001196	active site
91891001197	catalytic residues [active]
91891001198	metal binding site [ion binding]; metal-binding site
91891001199	homodimer binding site [polypeptide binding]; other site
91891001200	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
91891001201	carboxyltransferase (CT) interaction site; other site
91891001202	biotinylation site [posttranslational modification]; other site
91891001203	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
91891001204	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
91891001205	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
91891001206	active site
91891001207	Zn binding site [ion binding]; other site
91891001208	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891001209	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
91891001210	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
91891001211	putative catalytic site [active]
91891001212	putative metal binding site [ion binding]; other site
91891001213	putative phosphate binding site [ion binding]; other site
91891001214	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
91891001215	active site
91891001216	intersubunit interface [polypeptide binding]; other site
91891001217	catalytic residue [active]
91891001218	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
91891001219	ferredoxin-NADP reductase; Provisional; Region: PRK10926
91891001220	FAD binding pocket [chemical binding]; other site
91891001221	FAD binding motif [chemical binding]; other site
91891001222	phosphate binding motif [ion binding]; other site
91891001223	beta-alpha-beta structure motif; other site
91891001224	NAD binding pocket [chemical binding]; other site
91891001225	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
91891001226	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
91891001227	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
91891001228	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
91891001229	dimerization domain swap beta strand [polypeptide binding]; other site
91891001230	regulatory protein interface [polypeptide binding]; other site
91891001231	active site
91891001232	regulatory phosphorylation site [posttranslational modification]; other site
91891001233	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
91891001234	30S subunit binding site; other site
91891001235	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
91891001236	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
91891001237	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
91891001238	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
91891001239	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
91891001240	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
91891001241	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
91891001242	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
91891001243	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
91891001244	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
91891001245	oligomer interface [polypeptide binding]; other site
91891001246	active site
91891001247	metal binding site [ion binding]; metal-binding site
91891001248	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891001249	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
91891001250	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891001251	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
91891001252	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
91891001253	HflK protein; Region: hflK; TIGR01933
91891001254	FtsH protease regulator HflC; Provisional; Region: PRK11029
91891001255	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
91891001256	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
91891001257	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
91891001258	GDP-binding site [chemical binding]; other site
91891001259	ACT binding site; other site
91891001260	IMP binding site; other site
91891001261	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
91891001262	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
91891001263	Arginine repressor [Transcription]; Region: ArgR; COG1438
91891001264	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
91891001265	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891001266	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891001267	substrate binding pocket [chemical binding]; other site
91891001268	membrane-bound complex binding site; other site
91891001269	hinge residues; other site
91891001270	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
91891001271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891001272	dimer interface [polypeptide binding]; other site
91891001273	conserved gate region; other site
91891001274	putative PBP binding loops; other site
91891001275	ABC-ATPase subunit interface; other site
91891001276	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
91891001277	ATP-binding cassette domain of the binding protein-dependent transport systems; Region: ABC_Class3; cd03229
91891001278	Walker A/P-loop; other site
91891001279	ATP binding site [chemical binding]; other site
91891001280	Q-loop/lid; other site
91891001281	ABC transporter signature motif; other site
91891001282	Walker B; other site
91891001283	D-loop; other site
91891001284	H-loop/switch region; other site
91891001285	argininosuccinate synthase; Provisional; Region: PRK13820
91891001286	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
91891001287	ANP binding site [chemical binding]; other site
91891001288	Substrate Binding Site II [chemical binding]; other site
91891001289	Substrate Binding Site I [chemical binding]; other site
91891001290	Lyase; Region: Lyase_1; pfam00206
91891001291	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
91891001292	active sites [active]
91891001293	tetramer interface [polypeptide binding]; other site
91891001294	ornithine carbamoyltransferase; Provisional; Region: PRK00779
91891001295	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
91891001296	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
91891001297	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
91891001298	active site
91891001299	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
91891001300	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
91891001301	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
91891001302	C-terminal peptidase (prc); Region: prc; TIGR00225
91891001303	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
91891001304	protein binding site [polypeptide binding]; other site
91891001305	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
91891001306	Catalytic dyad [active]
91891001307	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
91891001308	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
91891001309	Peptidase family M23; Region: Peptidase_M23; pfam01551
91891001310	phosphoglyceromutase; Provisional; Region: PRK05434
91891001311	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
91891001312	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
91891001313	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
91891001314	catalytic residue [active]
91891001315	putative FPP diphosphate  binding site; other site
91891001316	putative FPP binding hydrophobic cleft; other site
91891001317	dimer interface [polypeptide binding]; other site
91891001318	putative IPP diphosphate binding site; other site
91891001319	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
91891001320	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
91891001321	zinc metallopeptidase RseP; Provisional; Region: PRK10779
91891001322	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
91891001323	active site
91891001324	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
91891001325	protein binding site [polypeptide binding]; other site
91891001326	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
91891001327	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
91891001328	putative substrate binding region [chemical binding]; other site
91891001329	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
91891001330	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
91891001331	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
91891001332	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
91891001333	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
91891001334	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
91891001335	Surface antigen; Region: Bac_surface_Ag; pfam01103
91891001336	periplasmic chaperone; Provisional; Region: PRK10780
91891001337	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
91891001338	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
91891001339	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
91891001340	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
91891001341	trimer interface [polypeptide binding]; other site
91891001342	active site
91891001343	UDP-GlcNAc binding site [chemical binding]; other site
91891001344	lipid binding site [chemical binding]; lipid-binding site
91891001345	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
91891001346	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
91891001347	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
91891001348	active site
91891001349	camphor resistance protein CrcB; Provisional; Region: PRK14217
91891001350	seryl-tRNA synthetase; Provisional; Region: PRK05431
91891001351	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
91891001352	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
91891001353	dimer interface [polypeptide binding]; other site
91891001354	active site
91891001355	motif 1; other site
91891001356	motif 2; other site
91891001357	motif 3; other site
91891001358	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
91891001359	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
91891001360	Methyltransferase domain; Region: Methyltransf_23; pfam13489
91891001361	Methyltransferase domain; Region: Methyltransf_12; pfam08242
91891001362	S-adenosylmethionine binding site [chemical binding]; other site
91891001363	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
91891001364	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
91891001365	active site
91891001366	catalytic tetrad [active]
91891001367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891001368	S-adenosylmethionine binding site [chemical binding]; other site
91891001369	Methyltransferase domain; Region: Methyltransf_23; pfam13489
91891001370	hypothetical protein; Provisional; Region: PRK08233
91891001371	AAA domain; Region: AAA_18; pfam13238
91891001372	active site
91891001373	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
91891001374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891001375	Coenzyme A binding pocket [chemical binding]; other site
91891001376	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
91891001377	Phosphotransferase enzyme family; Region: APH; pfam01636
91891001378	active site
91891001379	ATP binding site [chemical binding]; other site
91891001380	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
91891001381	substrate binding site [chemical binding]; other site
91891001382	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
91891001383	dimer interface [polypeptide binding]; other site
91891001384	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891001385	Mn binding site [ion binding]; other site
91891001386	K binding site [ion binding]; other site
91891001387	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
91891001388	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
91891001389	RDD family; Region: RDD; cl00746
91891001390	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
91891001391	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
91891001392	proximal quinone binding site [chemical binding]; other site
91891001393	SdhD (CybS) interface [polypeptide binding]; other site
91891001394	proximal heme binding site [chemical binding]; other site
91891001395	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
91891001396	SdhC subunit interface [polypeptide binding]; other site
91891001397	proximal heme binding site [chemical binding]; other site
91891001398	cardiolipin binding site; other site
91891001399	Iron-sulfur protein interface; other site
91891001400	proximal quinone binding site [chemical binding]; other site
91891001401	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
91891001402	L-aspartate oxidase; Provisional; Region: PRK06175
91891001403	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
91891001404	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
91891001405	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
91891001406	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
91891001407	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
91891001408	TPP-binding site [chemical binding]; other site
91891001409	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
91891001410	dimer interface [polypeptide binding]; other site
91891001411	PYR/PP interface [polypeptide binding]; other site
91891001412	TPP binding site [chemical binding]; other site
91891001413	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
91891001414	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
91891001415	E3 interaction surface; other site
91891001416	lipoyl attachment site [posttranslational modification]; other site
91891001417	e3 binding domain; Region: E3_binding; pfam02817
91891001418	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
91891001419	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
91891001420	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
91891001421	CoA-ligase; Region: Ligase_CoA; pfam00549
91891001422	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
91891001423	CoA binding domain; Region: CoA_binding; smart00881
91891001424	CoA-ligase; Region: Ligase_CoA; pfam00549
91891001425	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
91891001426	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
91891001427	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
91891001428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001429	D-galactonate transporter; Region: 2A0114; TIGR00893
91891001430	putative substrate translocation pore; other site
91891001431	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
91891001432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
91891001433	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
91891001434	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
91891001435	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
91891001436	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891001437	active site
91891001438	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
91891001439	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
91891001440	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
91891001441	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
91891001442	active site
91891001443	(T/H)XGH motif; other site
91891001444	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
91891001445	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
91891001446	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
91891001447	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
91891001448	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
91891001449	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
91891001450	ligand binding site [chemical binding]; other site
91891001451	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
91891001452	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
91891001453	putative acyl-acceptor binding pocket; other site
91891001454	multidrug efflux system protein; Provisional; Region: PRK11431
91891001455	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
91891001456	active site
91891001457	DNA polymerase IV; Validated; Region: PRK02406
91891001458	DNA binding site [nucleotide binding]
91891001459	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
91891001460	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
91891001461	DNA binding site [nucleotide binding]
91891001462	catalytic residue [active]
91891001463	H2TH interface [polypeptide binding]; other site
91891001464	putative catalytic residues [active]
91891001465	turnover-facilitating residue; other site
91891001466	intercalation triad [nucleotide binding]; other site
91891001467	8OG recognition residue [nucleotide binding]; other site
91891001468	putative reading head residues; other site
91891001469	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
91891001470	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
91891001471	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
91891001472	Fatty acid desaturase; Region: FA_desaturase; pfam00487
91891001473	Di-iron ligands [ion binding]; other site
91891001474	Transposase; Region: DDE_Tnp_ISL3; pfam01610
91891001475	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
91891001476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891001477	NAD(P) binding site [chemical binding]; other site
91891001478	active site
91891001479	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
91891001480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891001481	NAD(P) binding site [chemical binding]; other site
91891001482	active site
91891001483	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
91891001484	Phasin protein; Region: Phasin_2; cl11491
91891001485	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
91891001486	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
91891001487	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
91891001488	putative peptidase; Provisional; Region: PRK11649
91891001489	Peptidase family M23; Region: Peptidase_M23; pfam01551
91891001490	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
91891001491	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
91891001492	active site
91891001493	HIGH motif; other site
91891001494	dimer interface [polypeptide binding]; other site
91891001495	KMSKS motif; other site
91891001496	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
91891001497	RNA binding surface [nucleotide binding]; other site
91891001498	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
91891001499	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
91891001500	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
91891001501	trimer interface [polypeptide binding]; other site
91891001502	putative metal binding site [ion binding]; other site
91891001503	glutathione reductase; Validated; Region: PRK06116
91891001504	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
91891001505	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
91891001506	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
91891001507	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
91891001508	adenosine deaminase; Provisional; Region: PRK09358
91891001509	active site
91891001510	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
91891001511	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
91891001512	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
91891001513	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
91891001514	hypothetical protein; Validated; Region: PRK00228
91891001515	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
91891001516	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
91891001517	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
91891001518	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
91891001519	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
91891001520	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
91891001521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891001522	Walker A motif; other site
91891001523	ATP binding site [chemical binding]; other site
91891001524	Walker B motif; other site
91891001525	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
91891001526	Membrane fusogenic activity; Region: BMFP; pfam04380
91891001527	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
91891001528	Nitrogen regulatory protein P-II; Region: P-II; smart00938
91891001529	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
91891001530	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
91891001531	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
91891001532	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
91891001533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891001534	catalytic residue [active]
91891001535	Uncharacterized conserved protein [Function unknown]; Region: COG0398
91891001536	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
91891001537	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
91891001538	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
91891001539	putative acyl-acceptor binding pocket; other site
91891001540	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
91891001541	acyl-activating enzyme (AAE) consensus motif; other site
91891001542	AMP binding site [chemical binding]; other site
91891001543	active site
91891001544	CoA binding site [chemical binding]; other site
91891001545	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
91891001546	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
91891001547	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
91891001548	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
91891001549	Transcriptional regulator; Region: Rrf2; pfam02082
91891001550	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
91891001551	putative ABC transporter; Region: ycf24; CHL00085
91891001552	FeS assembly ATPase SufC; Region: sufC; TIGR01978
91891001553	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
91891001554	Walker A/P-loop; other site
91891001555	ATP binding site [chemical binding]; other site
91891001556	Q-loop/lid; other site
91891001557	ABC transporter signature motif; other site
91891001558	Walker B; other site
91891001559	D-loop; other site
91891001560	H-loop/switch region; other site
91891001561	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
91891001562	FeS assembly protein SufD; Region: sufD; TIGR01981
91891001563	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
91891001564	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
91891001565	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
91891001566	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891001567	catalytic residue [active]
91891001568	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
91891001569	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
91891001570	trimerization site [polypeptide binding]; other site
91891001571	active site
91891001572	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
91891001573	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
91891001574	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
91891001575	motif 1; other site
91891001576	dimer interface [polypeptide binding]; other site
91891001577	active site
91891001578	motif 2; other site
91891001579	motif 3; other site
91891001580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891001581	S-adenosylmethionine binding site [chemical binding]; other site
91891001582	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
91891001583	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
91891001584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001585	putative substrate translocation pore; other site
91891001586	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
91891001587	Domain of unknown function DUF21; Region: DUF21; pfam01595
91891001588	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
91891001589	Transporter associated domain; Region: CorC_HlyC; smart01091
91891001590	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
91891001591	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
91891001592	putative NAD(P) binding site [chemical binding]; other site
91891001593	putative substrate binding site [chemical binding]; other site
91891001594	catalytic Zn binding site [ion binding]; other site
91891001595	structural Zn binding site [ion binding]; other site
91891001596	dimer interface [polypeptide binding]; other site
91891001597	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
91891001598	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
91891001599	active site
91891001600	catalytic residues [active]
91891001601	metal binding site [ion binding]; metal-binding site
91891001602	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
91891001603	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
91891001604	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
91891001605	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
91891001606	CoA binding domain; Region: CoA_binding_2; pfam13380
91891001607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
91891001608	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
91891001609	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
91891001610	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
91891001611	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
91891001612	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
91891001613	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891001614	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
91891001615	Cupin domain; Region: Cupin_2; cl17218
91891001616	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
91891001617	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
91891001618	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
91891001619	Competence protein; Region: Competence; pfam03772
91891001620	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
91891001621	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
91891001622	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
91891001623	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
91891001624	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
91891001625	PilX N-terminal; Region: PilX_N; pfam14341
91891001626	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
91891001627	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
91891001628	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
91891001629	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
91891001630	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
91891001631	Type II transport protein GspH; Region: GspH; pfam12019
91891001632	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
91891001633	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
91891001634	putative active site [active]
91891001635	NodB motif; other site
91891001636	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
91891001637	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
91891001638	thymidine kinase; Provisional; Region: PRK04296
91891001639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001640	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891001641	putative substrate translocation pore; other site
91891001642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001643	putative substrate translocation pore; other site
91891001644	D-galactonate transporter; Region: 2A0114; TIGR00893
91891001645	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
91891001646	phosphopentomutase; Provisional; Region: PRK05362
91891001647	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
91891001648	active site
91891001649	HslU subunit interaction site [polypeptide binding]; other site
91891001650	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
91891001651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891001652	Walker A motif; other site
91891001653	ATP binding site [chemical binding]; other site
91891001654	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
91891001655	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
91891001656	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
91891001657	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
91891001658	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
91891001659	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
91891001660	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
91891001661	metal ion-dependent adhesion site (MIDAS); other site
91891001662	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
91891001663	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
91891001664	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
91891001665	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
91891001666	putative active site [active]
91891001667	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
91891001668	putative active site [active]
91891001669	putative catalytic site [active]
91891001670	putative DNA binding site [nucleotide binding]; other site
91891001671	putative phosphate binding site [ion binding]; other site
91891001672	metal binding site A [ion binding]; metal-binding site
91891001673	putative AP binding site [nucleotide binding]; other site
91891001674	putative metal binding site B [ion binding]; other site
91891001675	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
91891001676	putative catalytic site [active]
91891001677	putative phosphate binding site [ion binding]; other site
91891001678	active site
91891001679	metal binding site A [ion binding]; metal-binding site
91891001680	DNA binding site [nucleotide binding]
91891001681	putative AP binding site [nucleotide binding]; other site
91891001682	putative metal binding site B [ion binding]; other site
91891001683	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
91891001684	Malic enzyme, N-terminal domain; Region: malic; pfam00390
91891001685	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
91891001686	putative NAD(P) binding site [chemical binding]; other site
91891001687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001688	putative substrate translocation pore; other site
91891001689	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891001690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891001691	putative substrate translocation pore; other site
91891001692	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891001693	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
91891001694	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
91891001695	aromatic amino acid transport protein; Region: araaP; TIGR00837
91891001696	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
91891001697	aromatic amino acid transport protein; Region: araaP; TIGR00837
91891001698	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
91891001699	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891001700	ligand binding site [chemical binding]; other site
91891001701	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
91891001702	putative active site [active]
91891001703	N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
91891001704	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891001705	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
91891001706	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891001707	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
91891001708	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891001709	Walker A/P-loop; other site
91891001710	ATP binding site [chemical binding]; other site
91891001711	Q-loop/lid; other site
91891001712	ABC transporter signature motif; other site
91891001713	Walker B; other site
91891001714	D-loop; other site
91891001715	H-loop/switch region; other site
91891001716	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
91891001717	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
91891001718	Walker A/P-loop; other site
91891001719	ATP binding site [chemical binding]; other site
91891001720	Q-loop/lid; other site
91891001721	ABC transporter signature motif; other site
91891001722	Walker B; other site
91891001723	D-loop; other site
91891001724	H-loop/switch region; other site
91891001725	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
91891001726	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
91891001727	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
91891001728	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
91891001729	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
91891001730	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
91891001731	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
91891001732	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
91891001733	N-acetyl-D-glucosamine binding site [chemical binding]; other site
91891001734	catalytic residue [active]
91891001735	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
91891001736	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
91891001737	substrate binding site [chemical binding]; other site
91891001738	hexamer interface [polypeptide binding]; other site
91891001739	metal binding site [ion binding]; metal-binding site
91891001740	DoxX; Region: DoxX; pfam07681
91891001741	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
91891001742	hypothetical protein; Provisional; Region: PRK05409
91891001743	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
91891001744	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
91891001745	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
91891001746	nucleophile elbow; other site
91891001747	DoxX; Region: DoxX; pfam07681
91891001748	Predicted membrane protein [Function unknown]; Region: COG2259
91891001749	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
91891001750	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
91891001751	acetoacetate decarboxylase; Provisional; Region: PRK02265
91891001752	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
91891001753	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
91891001754	cyclase homology domain; Region: CHD; cd07302
91891001755	nucleotidyl binding site; other site
91891001756	metal binding site [ion binding]; metal-binding site
91891001757	dimer interface [polypeptide binding]; other site
91891001758	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
91891001759	hypothetical protein; Provisional; Region: PRK05409
91891001760	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891001761	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891001762	substrate binding pocket [chemical binding]; other site
91891001763	membrane-bound complex binding site; other site
91891001764	hinge residues; other site
91891001765	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
91891001766	metal binding triad; other site
91891001767	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
91891001768	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
91891001769	metal binding triad; other site
91891001770	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891001771	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891001772	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
91891001773	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
91891001774	Walker A/P-loop; other site
91891001775	ATP binding site [chemical binding]; other site
91891001776	Q-loop/lid; other site
91891001777	ABC transporter signature motif; other site
91891001778	Walker B; other site
91891001779	D-loop; other site
91891001780	H-loop/switch region; other site
91891001781	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
91891001782	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
91891001783	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
91891001784	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
91891001785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891001786	FeS/SAM binding site; other site
91891001787	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
91891001788	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
91891001789	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
91891001790	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
91891001791	DsbD alpha interface [polypeptide binding]; other site
91891001792	catalytic residues [active]
91891001793	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
91891001794	oligomerisation interface [polypeptide binding]; other site
91891001795	mobile loop; other site
91891001796	roof hairpin; other site
91891001797	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
91891001798	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
91891001799	ring oligomerisation interface [polypeptide binding]; other site
91891001800	ATP/Mg binding site [chemical binding]; other site
91891001801	stacking interactions; other site
91891001802	hinge regions; other site
91891001803	Ferritin-like domain; Region: Ferritin; pfam00210
91891001804	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
91891001805	dimerization interface [polypeptide binding]; other site
91891001806	DPS ferroxidase diiron center [ion binding]; other site
91891001807	ion pore; other site
91891001808	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891001809	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
91891001810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891001811	Mg2+ binding site [ion binding]; other site
91891001812	G-X-G motif; other site
91891001813	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
91891001814	anchoring element; other site
91891001815	dimer interface [polypeptide binding]; other site
91891001816	ATP binding site [chemical binding]; other site
91891001817	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
91891001818	active site
91891001819	metal binding site [ion binding]; metal-binding site
91891001820	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
91891001821	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
91891001822	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
91891001823	Walker A/P-loop; other site
91891001824	ATP binding site [chemical binding]; other site
91891001825	Q-loop/lid; other site
91891001826	ABC transporter signature motif; other site
91891001827	Walker B; other site
91891001828	D-loop; other site
91891001829	H-loop/switch region; other site
91891001830	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
91891001831	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
91891001832	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
91891001833	Walker A/P-loop; other site
91891001834	ATP binding site [chemical binding]; other site
91891001835	Q-loop/lid; other site
91891001836	ABC transporter signature motif; other site
91891001837	Walker B; other site
91891001838	D-loop; other site
91891001839	H-loop/switch region; other site
91891001840	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
91891001841	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891001842	prolyl-tRNA synthetase; Provisional; Region: PRK09194
91891001843	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
91891001844	dimer interface [polypeptide binding]; other site
91891001845	motif 1; other site
91891001846	active site
91891001847	motif 2; other site
91891001848	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
91891001849	putative deacylase active site [active]
91891001850	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
91891001851	active site
91891001852	motif 3; other site
91891001853	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
91891001854	anticodon binding site; other site
91891001855	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
91891001856	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891001857	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891001858	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891001859	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891001860	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891001861	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
91891001862	Sulfate transporter family; Region: Sulfate_transp; pfam00916
91891001863	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
91891001864	active site clefts [active]
91891001865	zinc binding site [ion binding]; other site
91891001866	dimer interface [polypeptide binding]; other site
91891001867	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
91891001868	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
91891001869	Ligand Binding Site [chemical binding]; other site
91891001870	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
91891001871	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
91891001872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891001873	S-adenosylmethionine binding site [chemical binding]; other site
91891001874	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
91891001875	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
91891001876	substrate-cofactor binding pocket; other site
91891001877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891001878	catalytic residue [active]
91891001879	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
91891001880	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
91891001881	NAD(P) binding site [chemical binding]; other site
91891001882	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
91891001883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891001884	Walker A/P-loop; other site
91891001885	ATP binding site [chemical binding]; other site
91891001886	Q-loop/lid; other site
91891001887	ABC transporter signature motif; other site
91891001888	Walker B; other site
91891001889	D-loop; other site
91891001890	H-loop/switch region; other site
91891001891	ABC transporter; Region: ABC_tran_2; pfam12848
91891001892	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891001893	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891001894	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
91891001895	Predicted transporter component [General function prediction only]; Region: COG2391
91891001896	Sulphur transport; Region: Sulf_transp; pfam04143
91891001897	Predicted transporter component [General function prediction only]; Region: COG2391
91891001898	Sulphur transport; Region: Sulf_transp; pfam04143
91891001899	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
91891001900	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891001901	formimidoylglutamase; Provisional; Region: PRK13775
91891001902	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
91891001903	putative active site [active]
91891001904	putative metal binding site [ion binding]; other site
91891001905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891001906	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
91891001907	NAD(P) binding site [chemical binding]; other site
91891001908	active site
91891001909	imidazolonepropionase; Validated; Region: PRK09356
91891001910	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
91891001911	active site
91891001912	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
91891001913	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
91891001914	Predicted membrane protein [Function unknown]; Region: COG1297
91891001915	putative oligopeptide transporter, OPT family; Region: TIGR00733
91891001916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
91891001917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891001918	dimer interface [polypeptide binding]; other site
91891001919	phosphorylation site [posttranslational modification]
91891001920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891001921	ATP binding site [chemical binding]; other site
91891001922	Mg2+ binding site [ion binding]; other site
91891001923	G-X-G motif; other site
91891001924	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
91891001925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891001926	active site
91891001927	phosphorylation site [posttranslational modification]
91891001928	intermolecular recognition site; other site
91891001929	dimerization interface [polypeptide binding]; other site
91891001930	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
91891001931	DNA binding site [nucleotide binding]
91891001932	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
91891001933	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
91891001934	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
91891001935	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
91891001936	HIGH motif; other site
91891001937	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
91891001938	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
91891001939	active site
91891001940	KMSKS motif; other site
91891001941	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
91891001942	tRNA binding surface [nucleotide binding]; other site
91891001943	anticodon binding site; other site
91891001944	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
91891001945	multidrug efflux protein; Reviewed; Region: PRK09579
91891001946	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
91891001947	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
91891001948	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891001949	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891001950	BON domain; Region: BON; pfam04972
91891001951	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
91891001952	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
91891001953	dimer interface [polypeptide binding]; other site
91891001954	active site
91891001955	glycine-pyridoxal phosphate binding site [chemical binding]; other site
91891001956	folate binding site [chemical binding]; other site
91891001957	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
91891001958	ATP cone domain; Region: ATP-cone; pfam03477
91891001959	transcription antitermination factor NusB; Region: nusB; TIGR01951
91891001960	putative RNA binding site [nucleotide binding]; other site
91891001961	thiamine monophosphate kinase; Provisional; Region: PRK05731
91891001962	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
91891001963	ATP binding site [chemical binding]; other site
91891001964	dimerization interface [polypeptide binding]; other site
91891001965	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
91891001966	tetramer interfaces [polypeptide binding]; other site
91891001967	binuclear metal-binding site [ion binding]; other site
91891001968	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
91891001969	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
91891001970	NAD synthetase; Provisional; Region: PRK13981
91891001971	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
91891001972	multimer interface [polypeptide binding]; other site
91891001973	active site
91891001974	catalytic triad [active]
91891001975	protein interface 1 [polypeptide binding]; other site
91891001976	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
91891001977	homodimer interface [polypeptide binding]; other site
91891001978	NAD binding pocket [chemical binding]; other site
91891001979	ATP binding pocket [chemical binding]; other site
91891001980	Mg binding site [ion binding]; other site
91891001981	active-site loop [active]
91891001982	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
91891001983	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891001984	ATP binding site [chemical binding]; other site
91891001985	putative Mg++ binding site [ion binding]; other site
91891001986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891001987	nucleotide binding region [chemical binding]; other site
91891001988	ATP-binding site [chemical binding]; other site
91891001989	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
91891001990	replicative DNA helicase; Region: DnaB; TIGR00665
91891001991	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
91891001992	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
91891001993	Walker A motif; other site
91891001994	ATP binding site [chemical binding]; other site
91891001995	Walker B motif; other site
91891001996	DNA binding loops [nucleotide binding]
91891001997	alanine racemase; Reviewed; Region: alr; PRK00053
91891001998	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
91891001999	active site
91891002000	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
91891002001	substrate binding site [chemical binding]; other site
91891002002	catalytic residues [active]
91891002003	dimer interface [polypeptide binding]; other site
91891002004	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
91891002005	FOG: CBS domain [General function prediction only]; Region: COG0517
91891002006	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
91891002007	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
91891002008	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
91891002009	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
91891002010	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891002011	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891002012	metal binding site [ion binding]; metal-binding site
91891002013	active site
91891002014	I-site; other site
91891002015	lipoyl synthase; Provisional; Region: PRK05481
91891002016	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891002017	FeS/SAM binding site; other site
91891002018	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
91891002019	GIY-YIG motif/motif A; other site
91891002020	putative active site [active]
91891002021	putative metal binding site [ion binding]; other site
91891002022	POT family; Region: PTR2; cl17359
91891002023	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
91891002024	Methyltransferase domain; Region: Methyltransf_11; pfam08241
91891002025	S-adenosylmethionine binding site [chemical binding]; other site
91891002026	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
91891002027	Ligand Binding Site [chemical binding]; other site
91891002028	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
91891002029	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
91891002030	substrate binding site [chemical binding]; other site
91891002031	glutamase interaction surface [polypeptide binding]; other site
91891002032	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
91891002033	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
91891002034	putative active site [active]
91891002035	oxyanion strand; other site
91891002036	catalytic triad [active]
91891002037	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
91891002038	ligand binding site; other site
91891002039	tetramer interface; other site
91891002040	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
91891002041	NeuB family; Region: NeuB; pfam03102
91891002042	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
91891002043	NeuB binding interface [polypeptide binding]; other site
91891002044	putative substrate binding site [chemical binding]; other site
91891002045	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
91891002046	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
91891002047	active site
91891002048	homodimer interface [polypeptide binding]; other site
91891002049	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
91891002050	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
91891002051	putative trimer interface [polypeptide binding]; other site
91891002052	putative CoA binding site [chemical binding]; other site
91891002053	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
91891002054	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
91891002055	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
91891002056	inhibitor-cofactor binding pocket; inhibition site
91891002057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891002058	catalytic residue [active]
91891002059	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
91891002060	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
91891002061	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
91891002062	NADP binding site [chemical binding]; other site
91891002063	active site
91891002064	putative substrate binding site [chemical binding]; other site
91891002065	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
91891002066	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
91891002067	NAD binding site [chemical binding]; other site
91891002068	substrate binding site [chemical binding]; other site
91891002069	homodimer interface [polypeptide binding]; other site
91891002070	active site
91891002071	Phosphoglucose isomerase; Region: PGI; pfam00342
91891002072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891002073	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
91891002074	active site
91891002075	dimer interface [polypeptide binding]; other site
91891002076	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
91891002077	dimer interface [polypeptide binding]; other site
91891002078	active site
91891002079	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
91891002080	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
91891002081	substrate binding site; other site
91891002082	tetramer interface; other site
91891002083	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
91891002084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891002085	NAD(P) binding site [chemical binding]; other site
91891002086	active site
91891002087	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
91891002088	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
91891002089	Mg++ binding site [ion binding]; other site
91891002090	putative catalytic motif [active]
91891002091	putative substrate binding site [chemical binding]; other site
91891002092	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
91891002093	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
91891002094	substrate binding site [chemical binding]; other site
91891002095	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
91891002096	NeuB family; Region: NeuB; pfam03102
91891002097	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
91891002098	NeuB binding interface [polypeptide binding]; other site
91891002099	putative substrate binding site [chemical binding]; other site
91891002100	Methyltransferase domain; Region: Methyltransf_31; pfam13847
91891002101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891002102	S-adenosylmethionine binding site [chemical binding]; other site
91891002103	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
91891002104	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
91891002105	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
91891002106	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
91891002107	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
91891002108	Walker A/P-loop; other site
91891002109	ATP binding site [chemical binding]; other site
91891002110	Q-loop/lid; other site
91891002111	ABC transporter signature motif; other site
91891002112	Walker B; other site
91891002113	D-loop; other site
91891002114	H-loop/switch region; other site
91891002115	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
91891002116	putative carbohydrate binding site [chemical binding]; other site
91891002117	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
91891002118	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
91891002119	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
91891002120	Probable Catalytic site; other site
91891002121	metal-binding site
91891002122	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
91891002123	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
91891002124	Probable Catalytic site; other site
91891002125	metal-binding site
91891002126	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
91891002127	carbon storage regulator; Provisional; Region: PRK01712
91891002128	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
91891002129	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
91891002130	Biotin operon repressor [Transcription]; Region: BirA; COG1654
91891002131	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
91891002132	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
91891002133	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
91891002134	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
91891002135	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
91891002136	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
91891002137	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
91891002138	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
91891002139	Ligand Binding Site [chemical binding]; other site
91891002140	TilS substrate binding domain; Region: TilS; pfam09179
91891002141	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
91891002142	Transposase IS200 like; Region: Y1_Tnp; cl00848
91891002143	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
91891002144	active site
91891002145	oxyanion hole [active]
91891002146	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
91891002147	catalytic triad [active]
91891002148	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
91891002149	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
91891002150	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
91891002151	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
91891002152	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
91891002153	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
91891002154	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
91891002155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891002156	muropeptide transporter; Reviewed; Region: ampG; PRK11902
91891002157	putative substrate translocation pore; other site
91891002158	Protein of unknown function (DUF3757); Region: DUF3757; pfam12582
91891002159	Quinolinate synthetase A protein; Region: NadA; pfam02445
91891002160	L-aspartate oxidase; Provisional; Region: PRK09077
91891002161	L-aspartate oxidase; Provisional; Region: PRK06175
91891002162	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
91891002163	adenylosuccinate lyase; Provisional; Region: PRK09285
91891002164	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
91891002165	tetramer interface [polypeptide binding]; other site
91891002166	active site
91891002167	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
91891002168	putative transporter; Provisional; Region: PRK11660
91891002169	Sulfate transporter family; Region: Sulfate_transp; pfam00916
91891002170	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
91891002171	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
91891002172	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
91891002173	active site
91891002174	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
91891002175	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
91891002176	active site
91891002177	phosphoenolpyruvate synthase; Validated; Region: PRK06464
91891002178	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
91891002179	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
91891002180	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
91891002181	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
91891002182	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
91891002183	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
91891002184	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
91891002185	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
91891002186	dimerization interface [polypeptide binding]; other site
91891002187	active site
91891002188	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
91891002189	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
91891002190	active site
91891002191	homodimer interface [polypeptide binding]; other site
91891002192	hypothetical protein; Provisional; Region: PRK08201
91891002193	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
91891002194	metal binding site [ion binding]; metal-binding site
91891002195	putative dimer interface [polypeptide binding]; other site
91891002196	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
91891002197	rod shape-determining protein MreB; Provisional; Region: PRK13927
91891002198	MreB and similar proteins; Region: MreB_like; cd10225
91891002199	nucleotide binding site [chemical binding]; other site
91891002200	Mg binding site [ion binding]; other site
91891002201	putative protofilament interaction site [polypeptide binding]; other site
91891002202	RodZ interaction site [polypeptide binding]; other site
91891002203	rod shape-determining protein MreC; Provisional; Region: PRK13922
91891002204	rod shape-determining protein MreC; Region: MreC; pfam04085
91891002205	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
91891002206	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
91891002207	pseudouridine synthase; Region: TIGR00093
91891002208	active site
91891002209	isocitrate dehydrogenase; Validated; Region: PRK07362
91891002210	isocitrate dehydrogenase; Reviewed; Region: PRK07006
91891002211	Uncharacterized conserved protein [Function unknown]; Region: COG2127
91891002212	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
91891002213	Clp amino terminal domain; Region: Clp_N; pfam02861
91891002214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891002215	Walker A motif; other site
91891002216	ATP binding site [chemical binding]; other site
91891002217	Walker B motif; other site
91891002218	arginine finger; other site
91891002219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891002220	Walker A motif; other site
91891002221	ATP binding site [chemical binding]; other site
91891002222	Walker B motif; other site
91891002223	arginine finger; other site
91891002224	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
91891002225	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
91891002226	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
91891002227	putative metal binding site; other site
91891002228	Rhomboid family; Region: Rhomboid; cl11446
91891002229	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
91891002230	Peptidase family M23; Region: Peptidase_M23; pfam01551
91891002231	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
91891002232	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
91891002233	generic binding surface II; other site
91891002234	generic binding surface I; other site
91891002235	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
91891002236	Sporulation related domain; Region: SPOR; pfam05036
91891002237	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
91891002238	biofilm formation regulator HmsP; Provisional; Region: PRK11829
91891002239	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
91891002240	dimerization interface [polypeptide binding]; other site
91891002241	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891002242	metal binding site [ion binding]; metal-binding site
91891002243	active site
91891002244	I-site; other site
91891002245	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891002246	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
91891002247	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
91891002248	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
91891002249	hypothetical protein; Provisional; Region: PRK06194
91891002250	classical (c) SDRs; Region: SDR_c; cd05233
91891002251	NAD(P) binding site [chemical binding]; other site
91891002252	active site
91891002253	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
91891002254	active site
91891002255	ribulose/triose binding site [chemical binding]; other site
91891002256	phosphate binding site [ion binding]; other site
91891002257	substrate (anthranilate) binding pocket [chemical binding]; other site
91891002258	product (indole) binding pocket [chemical binding]; other site
91891002259	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
91891002260	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
91891002261	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
91891002262	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
91891002263	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
91891002264	glutamine binding [chemical binding]; other site
91891002265	catalytic triad [active]
91891002266	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
91891002267	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
91891002268	Walker A/P-loop; other site
91891002269	ATP binding site [chemical binding]; other site
91891002270	Q-loop/lid; other site
91891002271	ABC transporter signature motif; other site
91891002272	Walker B; other site
91891002273	D-loop; other site
91891002274	H-loop/switch region; other site
91891002275	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
91891002276	OstA-like protein; Region: OstA; pfam03968
91891002277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
91891002278	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
91891002279	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
91891002280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891002281	active site
91891002282	motif I; other site
91891002283	motif II; other site
91891002284	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
91891002285	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
91891002286	putative active site [active]
91891002287	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
91891002288	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
91891002289	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
91891002290	Walker A/P-loop; other site
91891002291	ATP binding site [chemical binding]; other site
91891002292	Q-loop/lid; other site
91891002293	ABC transporter signature motif; other site
91891002294	Walker B; other site
91891002295	D-loop; other site
91891002296	H-loop/switch region; other site
91891002297	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
91891002298	Permease; Region: Permease; cl00510
91891002299	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
91891002300	mce related protein; Region: MCE; pfam02470
91891002301	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
91891002302	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
91891002303	anti sigma factor interaction site; other site
91891002304	regulatory phosphorylation site [posttranslational modification]; other site
91891002305	BolA-like protein; Region: BolA; cl00386
91891002306	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
91891002307	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
91891002308	hinge; other site
91891002309	active site
91891002310	Uncharacterized conserved protein [Function unknown]; Region: COG0327
91891002311	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
91891002312	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
91891002313	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
91891002314	Walker A/P-loop; other site
91891002315	ATP binding site [chemical binding]; other site
91891002316	Q-loop/lid; other site
91891002317	ABC transporter signature motif; other site
91891002318	Walker B; other site
91891002319	D-loop; other site
91891002320	H-loop/switch region; other site
91891002321	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
91891002322	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
91891002323	FtsX-like permease family; Region: FtsX; pfam02687
91891002324	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
91891002325	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891002326	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891002327	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
91891002328	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
91891002329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891002330	Walker A motif; other site
91891002331	ATP binding site [chemical binding]; other site
91891002332	Walker B motif; other site
91891002333	arginine finger; other site
91891002334	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
91891002335	putative inner membrane peptidase; Provisional; Region: PRK11778
91891002336	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
91891002337	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
91891002338	tandem repeat interface [polypeptide binding]; other site
91891002339	oligomer interface [polypeptide binding]; other site
91891002340	active site residues [active]
91891002341	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540
91891002342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891002343	Walker A/P-loop; other site
91891002344	ATP binding site [chemical binding]; other site
91891002345	Q-loop/lid; other site
91891002346	ABC transporter signature motif; other site
91891002347	Walker B; other site
91891002348	D-loop; other site
91891002349	H-loop/switch region; other site
91891002350	CcmB protein; Region: CcmB; cl17444
91891002351	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
91891002352	heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141
91891002353	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
91891002354	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
91891002355	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
91891002356	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
91891002357	catalytic residues [active]
91891002358	central insert; other site
91891002359	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
91891002360	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891002361	binding surface
91891002362	TPR motif; other site
91891002363	Dodecin; Region: Dodecin; pfam07311
91891002364	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
91891002365	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
91891002366	active site
91891002367	DNA binding site [nucleotide binding]
91891002368	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
91891002369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891002370	ATP binding site [chemical binding]; other site
91891002371	putative Mg++ binding site [ion binding]; other site
91891002372	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891002373	nucleotide binding region [chemical binding]; other site
91891002374	ATP-binding site [chemical binding]; other site
91891002375	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
91891002376	HRDC domain; Region: HRDC; pfam00570
91891002377	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
91891002378	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
91891002379	active site
91891002380	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
91891002381	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
91891002382	substrate binding site [chemical binding]; other site
91891002383	oxyanion hole (OAH) forming residues; other site
91891002384	trimer interface [polypeptide binding]; other site
91891002385	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
91891002386	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
91891002387	substrate binding site [chemical binding]; other site
91891002388	oxyanion hole (OAH) forming residues; other site
91891002389	trimer interface [polypeptide binding]; other site
91891002390	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
91891002391	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
91891002392	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
91891002393	G1 box; other site
91891002394	putative GEF interaction site [polypeptide binding]; other site
91891002395	GTP/Mg2+ binding site [chemical binding]; other site
91891002396	Switch I region; other site
91891002397	G2 box; other site
91891002398	G3 box; other site
91891002399	Switch II region; other site
91891002400	G4 box; other site
91891002401	G5 box; other site
91891002402	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
91891002403	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
91891002404	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
91891002405	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
91891002406	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
91891002407	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
91891002408	ligand binding site [chemical binding]; other site
91891002409	homodimer interface [polypeptide binding]; other site
91891002410	NAD(P) binding site [chemical binding]; other site
91891002411	trimer interface B [polypeptide binding]; other site
91891002412	trimer interface A [polypeptide binding]; other site
91891002413	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
91891002414	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
91891002415	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
91891002416	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891002417	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891002418	metal binding site [ion binding]; metal-binding site
91891002419	active site
91891002420	I-site; other site
91891002421	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
91891002422	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
91891002423	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
91891002424	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
91891002425	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
91891002426	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
91891002427	metal binding site [ion binding]; metal-binding site
91891002428	dimer interface [polypeptide binding]; other site
91891002429	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
91891002430	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
91891002431	trimer interface [polypeptide binding]; other site
91891002432	active site
91891002433	substrate binding site [chemical binding]; other site
91891002434	CoA binding site [chemical binding]; other site
91891002435	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
91891002436	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
91891002437	putative acyl-acceptor binding pocket; other site
91891002438	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
91891002439	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
91891002440	homodimer interface [polypeptide binding]; other site
91891002441	substrate-cofactor binding pocket; other site
91891002442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891002443	catalytic residue [active]
91891002444	PAS fold; Region: PAS_7; pfam12860
91891002445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891002446	PAS domain; Region: PAS_9; pfam13426
91891002447	putative active site [active]
91891002448	heme pocket [chemical binding]; other site
91891002449	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891002450	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891002451	metal binding site [ion binding]; metal-binding site
91891002452	active site
91891002453	I-site; other site
91891002454	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891002455	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
91891002456	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
91891002457	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
91891002458	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
91891002459	FAD binding domain; Region: FAD_binding_4; pfam01565
91891002460	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
91891002461	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
91891002462	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891002463	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
91891002464	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
91891002465	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
91891002466	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
91891002467	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
91891002468	minor groove reading motif; other site
91891002469	helix-hairpin-helix signature motif; other site
91891002470	substrate binding pocket [chemical binding]; other site
91891002471	active site
91891002472	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
91891002473	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
91891002474	DNA binding and oxoG recognition site [nucleotide binding]
91891002475	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
91891002476	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
91891002477	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
91891002478	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
91891002479	protein binding site [polypeptide binding]; other site
91891002480	Isochorismatase family; Region: Isochorismatase; pfam00857
91891002481	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
91891002482	catalytic triad [active]
91891002483	dimer interface [polypeptide binding]; other site
91891002484	conserved cis-peptide bond; other site
91891002485	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
91891002486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891002487	NAD(P) binding site [chemical binding]; other site
91891002488	active site
91891002489	FlgN protein; Region: FlgN; pfam05130
91891002490	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
91891002491	SAF-like; Region: SAF_2; pfam13144
91891002492	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
91891002493	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
91891002494	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891002495	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
91891002496	nucleotide binding site [chemical binding]; other site
91891002497	Type III pantothenate kinase; Region: Pan_kinase; cl17198
91891002498	cell division protein MraZ; Reviewed; Region: PRK00326
91891002499	MraZ protein; Region: MraZ; pfam02381
91891002500	MraZ protein; Region: MraZ; pfam02381
91891002501	MraW methylase family; Region: Methyltransf_5; cl17771
91891002502	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
91891002503	Cell division protein FtsL; Region: FtsL; cl11433
91891002504	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
91891002505	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
91891002506	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
91891002507	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
91891002508	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
91891002509	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
91891002510	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
91891002511	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
91891002512	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
91891002513	ligand binding site [chemical binding]; other site
91891002514	NAD binding site [chemical binding]; other site
91891002515	catalytic site [active]
91891002516	homodimer interface [polypeptide binding]; other site
91891002517	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
91891002518	Peptidase family M50; Region: Peptidase_M50; pfam02163
91891002519	active site
91891002520	putative substrate binding region [chemical binding]; other site
91891002521	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
91891002522	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
91891002523	active site
91891002524	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
91891002525	Ligand binding site [chemical binding]; other site
91891002526	Electron transfer flavoprotein domain; Region: ETF; pfam01012
91891002527	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
91891002528	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
91891002529	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
91891002530	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
91891002531	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
91891002532	hexamer interface [polypeptide binding]; other site
91891002533	ligand binding site [chemical binding]; other site
91891002534	putative active site [active]
91891002535	NAD(P) binding site [chemical binding]; other site
91891002536	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
91891002537	Transglycosylase; Region: Transgly; pfam00912
91891002538	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
91891002539	Cell division protein FtsA; Region: FtsA; cl17206
91891002540	Competence protein A; Region: Competence_A; pfam11104
91891002541	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
91891002542	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
91891002543	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
91891002544	Pilus assembly protein, PilO; Region: PilO; pfam04350
91891002545	Pilus assembly protein, PilP; Region: PilP; pfam04351
91891002546	AMIN domain; Region: AMIN; pfam11741
91891002547	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
91891002548	Secretin and TonB N terminus short domain; Region: STN; smart00965
91891002549	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
91891002550	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
91891002551	shikimate kinase; Reviewed; Region: aroK; PRK00131
91891002552	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
91891002553	ADP binding site [chemical binding]; other site
91891002554	magnesium binding site [ion binding]; other site
91891002555	putative shikimate binding site; other site
91891002556	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
91891002557	active site
91891002558	dimer interface [polypeptide binding]; other site
91891002559	metal binding site [ion binding]; metal-binding site
91891002560	AAA domain; Region: AAA_22; pfam13401
91891002561	Sporulation related domain; Region: SPOR; pfam05036
91891002562	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
91891002563	Ligand Binding Site [chemical binding]; other site
91891002564	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
91891002565	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
91891002566	active site
91891002567	Riboflavin kinase; Region: Flavokinase; smart00904
91891002568	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
91891002569	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891002570	active site
91891002571	HIGH motif; other site
91891002572	nucleotide binding site [chemical binding]; other site
91891002573	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
91891002574	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
91891002575	active site
91891002576	KMSKS motif; other site
91891002577	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
91891002578	tRNA binding surface [nucleotide binding]; other site
91891002579	anticodon binding site; other site
91891002580	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
91891002581	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
91891002582	lipoprotein signal peptidase; Provisional; Region: PRK14787
91891002583	Class I aldolases; Region: Aldolase_Class_I; cl17187
91891002584	catalytic residue [active]
91891002585	GTPase Era; Reviewed; Region: era; PRK00089
91891002586	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
91891002587	G1 box; other site
91891002588	GTP/Mg2+ binding site [chemical binding]; other site
91891002589	Switch I region; other site
91891002590	G2 box; other site
91891002591	Switch II region; other site
91891002592	G3 box; other site
91891002593	G4 box; other site
91891002594	G5 box; other site
91891002595	KH domain; Region: KH_2; pfam07650
91891002596	Recombination protein O N terminal; Region: RecO_N; pfam11967
91891002597	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
91891002598	Recombination protein O C terminal; Region: RecO_C; pfam02565
91891002599	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
91891002600	Leucine-rich repeats; other site
91891002601	Substrate binding site [chemical binding]; other site
91891002602	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
91891002603	active site
91891002604	hydrophilic channel; other site
91891002605	dimerization interface [polypeptide binding]; other site
91891002606	catalytic residues [active]
91891002607	active site lid [active]
91891002608	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
91891002609	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
91891002610	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
91891002611	dimer interface [polypeptide binding]; other site
91891002612	PYR/PP interface [polypeptide binding]; other site
91891002613	TPP binding site [chemical binding]; other site
91891002614	substrate binding site [chemical binding]; other site
91891002615	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
91891002616	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
91891002617	TPP-binding site [chemical binding]; other site
91891002618	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
91891002619	YccA-like proteins; Region: YccA_like; cd10433
91891002620	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
91891002621	nitrilase; Region: PLN02798
91891002622	putative active site [active]
91891002623	catalytic triad [active]
91891002624	dimer interface [polypeptide binding]; other site
91891002625	protease TldD; Provisional; Region: tldD; PRK10735
91891002626	hypothetical protein; Provisional; Region: PRK10279
91891002627	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
91891002628	active site
91891002629	nucleophile elbow; other site
91891002630	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
91891002631	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
91891002632	acyl-activating enzyme (AAE) consensus motif; other site
91891002633	putative AMP binding site [chemical binding]; other site
91891002634	putative active site [active]
91891002635	putative CoA binding site [chemical binding]; other site
91891002636	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
91891002637	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
91891002638	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891002639	ATP binding site [chemical binding]; other site
91891002640	putative Mg++ binding site [ion binding]; other site
91891002641	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891002642	nucleotide binding region [chemical binding]; other site
91891002643	ATP-binding site [chemical binding]; other site
91891002644	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
91891002645	RmuC family; Region: RmuC; pfam02646
91891002646	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
91891002647	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
91891002648	nucleotide binding pocket [chemical binding]; other site
91891002649	K-X-D-G motif; other site
91891002650	catalytic site [active]
91891002651	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
91891002652	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
91891002653	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
91891002654	Dimer interface [polypeptide binding]; other site
91891002655	BRCT sequence motif; other site
91891002656	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
91891002657	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
91891002658	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
91891002659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891002660	dimer interface [polypeptide binding]; other site
91891002661	conserved gate region; other site
91891002662	putative PBP binding loops; other site
91891002663	ABC-ATPase subunit interface; other site
91891002664	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
91891002665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891002666	dimer interface [polypeptide binding]; other site
91891002667	conserved gate region; other site
91891002668	putative PBP binding loops; other site
91891002669	ABC-ATPase subunit interface; other site
91891002670	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
91891002671	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
91891002672	putative active site [active]
91891002673	putative PHP Thumb interface [polypeptide binding]; other site
91891002674	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
91891002675	generic binding surface II; other site
91891002676	generic binding surface I; other site
91891002677	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
91891002678	UbiA prenyltransferase family; Region: UbiA; pfam01040
91891002679	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
91891002680	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
91891002681	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
91891002682	NAD(P) binding site [chemical binding]; other site
91891002683	homodimer interface [polypeptide binding]; other site
91891002684	substrate binding site [chemical binding]; other site
91891002685	active site
91891002686	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891002687	GIY-YIG motif/motif A; other site
91891002688	putative active site [active]
91891002689	putative metal binding site [ion binding]; other site
91891002690	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
91891002691	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
91891002692	nucleotide binding site [chemical binding]; other site
91891002693	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
91891002694	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891002695	ATP binding site [chemical binding]; other site
91891002696	putative Mg++ binding site [ion binding]; other site
91891002697	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891002698	nucleotide binding region [chemical binding]; other site
91891002699	ATP-binding site [chemical binding]; other site
91891002700	Restriction endonuclease; Region: Mrr_cat; pfam04471
91891002701	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
91891002702	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891002703	ligand binding site [chemical binding]; other site
91891002704	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
91891002705	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
91891002706	dimer interface [polypeptide binding]; other site
91891002707	putative CheW interface [polypeptide binding]; other site
91891002708	Helix-turn-helix domain; Region: HTH_17; cl17695
91891002709	Domain of unknown function (DUF927); Region: DUF927; pfam06048
91891002710	Integrase; Region: Integrase_1; pfam12835
91891002711	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
91891002712	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
91891002713	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
91891002714	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
91891002715	active site
91891002716	DNA binding site [nucleotide binding]
91891002717	Int/Topo IB signature motif; other site
91891002718	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor
91891002719	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor
91891002720	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
91891002721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891002722	Coenzyme A binding pocket [chemical binding]; other site
91891002723	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
91891002724	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
91891002725	Methyltransferase domain; Region: Methyltransf_23; pfam13489
91891002726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891002727	S-adenosylmethionine binding site [chemical binding]; other site
91891002728	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
91891002729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891002730	Coenzyme A binding pocket [chemical binding]; other site
91891002731	HipA N-terminal domain; Region: Couple_hipA; pfam13657
91891002732	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
91891002733	HipA-like N-terminal domain; Region: HipA_N; pfam07805
91891002734	HipA-like C-terminal domain; Region: HipA_C; pfam07804
91891002735	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891002736	non-specific DNA binding site [nucleotide binding]; other site
91891002737	salt bridge; other site
91891002738	sequence-specific DNA binding site [nucleotide binding]; other site
91891002739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891002740	Coenzyme A binding pocket [chemical binding]; other site
91891002741	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
91891002742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891002743	motif II; other site
91891002744	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
91891002745	Phosphotransferase enzyme family; Region: APH; pfam01636
91891002746	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
91891002747	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
91891002748	methionine sulfoxide reductase B; Provisional; Region: PRK00222
91891002749	SelR domain; Region: SelR; pfam01641
91891002750	Predicted membrane protein [Function unknown]; Region: COG4325
91891002751	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
91891002752	EamA-like transporter family; Region: EamA; cl17759
91891002753	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891002754	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891002755	GIY-YIG motif/motif A; other site
91891002756	putative active site [active]
91891002757	putative metal binding site [ion binding]; other site
91891002758	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891002759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891002760	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891002761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891002762	PAS domain; Region: PAS_9; pfam13426
91891002763	putative active site [active]
91891002764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891002765	PAS domain; Region: PAS_9; pfam13426
91891002766	putative active site [active]
91891002767	heme pocket [chemical binding]; other site
91891002768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891002769	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891002770	metal binding site [ion binding]; metal-binding site
91891002771	active site
91891002772	I-site; other site
91891002773	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891002774	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
91891002775	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
91891002776	tetramer interface [polypeptide binding]; other site
91891002777	dimer interface [polypeptide binding]; other site
91891002778	circadian clock protein KaiC; Reviewed; Region: PRK09302
91891002779	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891002780	Walker A motif; other site
91891002781	ATP binding site [chemical binding]; other site
91891002782	Walker B motif; other site
91891002783	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891002784	Walker A motif; other site
91891002785	ATP binding site [chemical binding]; other site
91891002786	Walker B motif; other site
91891002787	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
91891002788	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
91891002789	active site
91891002790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891002791	Coenzyme A binding pocket [chemical binding]; other site
91891002792	Beta-lactamase; Region: Beta-lactamase; pfam00144
91891002793	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
91891002794	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
91891002795	catalytic core [active]
91891002796	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
91891002797	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
91891002798	N-acetyl-D-glucosamine binding site [chemical binding]; other site
91891002799	catalytic residue [active]
91891002800	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891002801	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
91891002802	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891002803	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891002804	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891002805	substrate binding pocket [chemical binding]; other site
91891002806	membrane-bound complex binding site; other site
91891002807	hinge residues; other site
91891002808	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891002809	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891002810	substrate binding pocket [chemical binding]; other site
91891002811	membrane-bound complex binding site; other site
91891002812	hinge residues; other site
91891002813	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
91891002814	Soluble P-type ATPase [General function prediction only]; Region: COG4087
91891002815	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891002816	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891002817	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891002818	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891002819	putative active site [active]
91891002820	GIY-YIG motif/motif A; other site
91891002821	putative metal binding site [ion binding]; other site
91891002822	putative cation:proton antiport protein; Provisional; Region: PRK10669
91891002823	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
91891002824	TrkA-N domain; Region: TrkA_N; pfam02254
91891002825	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
91891002826	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
91891002827	acyl-activating enzyme (AAE) consensus motif; other site
91891002828	AMP binding site [chemical binding]; other site
91891002829	active site
91891002830	CoA binding site [chemical binding]; other site
91891002831	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
91891002832	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
91891002833	dimerization interface [polypeptide binding]; other site
91891002834	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
91891002835	cyclase homology domain; Region: CHD; cd07302
91891002836	nucleotidyl binding site; other site
91891002837	metal binding site [ion binding]; metal-binding site
91891002838	dimer interface [polypeptide binding]; other site
91891002839	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
91891002840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891002841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891002842	S-adenosylmethionine binding site [chemical binding]; other site
91891002843	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
91891002844	COQ9; Region: COQ9; pfam08511
91891002845	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
91891002846	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
91891002847	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
91891002848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
91891002849	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
91891002850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891002851	dimer interface [polypeptide binding]; other site
91891002852	conserved gate region; other site
91891002853	putative PBP binding loops; other site
91891002854	ABC-ATPase subunit interface; other site
91891002855	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
91891002856	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
91891002857	Walker A/P-loop; other site
91891002858	ATP binding site [chemical binding]; other site
91891002859	Q-loop/lid; other site
91891002860	ABC transporter signature motif; other site
91891002861	Walker B; other site
91891002862	D-loop; other site
91891002863	H-loop/switch region; other site
91891002864	TOBE domain; Region: TOBE_2; pfam08402
91891002865	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
91891002866	NADP binding site [chemical binding]; other site
91891002867	active site
91891002868	steroid binding site; other site
91891002869	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
91891002870	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
91891002871	active site
91891002872	Zn binding site [ion binding]; other site
91891002873	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891002874	Coenzyme A binding pocket [chemical binding]; other site
91891002875	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
91891002876	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
91891002877	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
91891002878	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
91891002879	DNA binding site [nucleotide binding]
91891002880	active site
91891002881	probable polyamine oxidase; Region: PLN02268
91891002882	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
91891002883	pyruvate decarboxylase; Region: PLN02573
91891002884	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
91891002885	dimer interface [polypeptide binding]; other site
91891002886	PYR/PP interface [polypeptide binding]; other site
91891002887	TPP binding site [chemical binding]; other site
91891002888	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
91891002889	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
91891002890	TPP-binding site [chemical binding]; other site
91891002891	dimer interface [polypeptide binding]; other site
91891002892	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
91891002893	Peptidase family M28; Region: Peptidase_M28; pfam04389
91891002894	metal binding site [ion binding]; metal-binding site
91891002895	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891002896	Putative serine esterase (DUF676); Region: DUF676; pfam05057
91891002897	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891002898	active site
91891002899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891002900	metabolite-proton symporter; Region: 2A0106; TIGR00883
91891002901	putative substrate translocation pore; other site
91891002902	acetylornithine deacetylase; Provisional; Region: PRK07522
91891002903	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
91891002904	metal binding site [ion binding]; metal-binding site
91891002905	putative dimer interface [polypeptide binding]; other site
91891002906	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
91891002907	7kD viral coat protein; Region: 7kD_coat; pfam02495
91891002908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
91891002909	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
91891002910	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891002911	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891002912	metal binding site [ion binding]; metal-binding site
91891002913	active site
91891002914	I-site; other site
91891002915	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891002916	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
91891002917	putative ligand binding pocket/active site [active]
91891002918	putative metal binding site [ion binding]; other site
91891002919	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
91891002920	AMMECR1; Region: AMMECR1; pfam01871
91891002921	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
91891002922	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891002923	FeS/SAM binding site; other site
91891002924	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891002925	Sel1-like repeats; Region: SEL1; smart00671
91891002926	Sel1-like repeats; Region: SEL1; smart00671
91891002927	Sel1-like repeats; Region: SEL1; smart00671
91891002928	Sel1-like repeats; Region: SEL1; smart00671
91891002929	Sel1-like repeats; Region: SEL1; smart00671
91891002930	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891002931	Sel1-like repeats; Region: SEL1; smart00671
91891002932	Sel1-like repeats; Region: SEL1; smart00671
91891002933	Sel1-like repeats; Region: SEL1; smart00671
91891002934	Sel1-like repeats; Region: SEL1; smart00671
91891002935	Sel1-like repeats; Region: SEL1; smart00671
91891002936	Sel1-like repeats; Region: SEL1; smart00671
91891002937	Sel1-like repeats; Region: SEL1; smart00671
91891002938	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
91891002939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891002940	dimer interface [polypeptide binding]; other site
91891002941	phosphorylation site [posttranslational modification]
91891002942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891002943	ATP binding site [chemical binding]; other site
91891002944	Mg2+ binding site [ion binding]; other site
91891002945	G-X-G motif; other site
91891002946	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
91891002947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891002948	active site
91891002949	phosphorylation site [posttranslational modification]
91891002950	intermolecular recognition site; other site
91891002951	dimerization interface [polypeptide binding]; other site
91891002952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891002953	Walker A motif; other site
91891002954	ATP binding site [chemical binding]; other site
91891002955	Walker B motif; other site
91891002956	arginine finger; other site
91891002957	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
91891002958	AsnC family; Region: AsnC_trans_reg; pfam01037
91891002959	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891002960	Peptidase family M48; Region: Peptidase_M48; pfam01435
91891002961	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
91891002962	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
91891002963	catalytic motif [active]
91891002964	Zn binding site [ion binding]; other site
91891002965	RibD C-terminal domain; Region: RibD_C; cl17279
91891002966	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
91891002967	Lumazine binding domain; Region: Lum_binding; pfam00677
91891002968	Lumazine binding domain; Region: Lum_binding; pfam00677
91891002969	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
91891002970	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
91891002971	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
91891002972	dimerization interface [polypeptide binding]; other site
91891002973	active site
91891002974	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
91891002975	homopentamer interface [polypeptide binding]; other site
91891002976	active site
91891002977	CTP synthetase; Validated; Region: pyrG; PRK05380
91891002978	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
91891002979	Catalytic site [active]
91891002980	active site
91891002981	UTP binding site [chemical binding]; other site
91891002982	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
91891002983	active site
91891002984	putative oxyanion hole; other site
91891002985	catalytic triad [active]
91891002986	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
91891002987	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
91891002988	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
91891002989	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
91891002990	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
91891002991	Putative exonuclease, RdgC; Region: RdgC; pfam04381
91891002992	K+ potassium transporter; Region: K_trans; pfam02705
91891002993	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
91891002994	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
91891002995	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
91891002996	putative RNA binding site [nucleotide binding]; other site
91891002997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891002998	S-adenosylmethionine binding site [chemical binding]; other site
91891002999	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
91891003000	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
91891003001	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
91891003002	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
91891003003	conserved cys residue [active]
91891003004	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
91891003005	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
91891003006	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
91891003007	metal binding site [ion binding]; metal-binding site
91891003008	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
91891003009	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
91891003010	substrate binding site [chemical binding]; other site
91891003011	glutamase interaction surface [polypeptide binding]; other site
91891003012	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
91891003013	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
91891003014	catalytic residues [active]
91891003015	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
91891003016	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
91891003017	putative active site [active]
91891003018	oxyanion strand; other site
91891003019	catalytic triad [active]
91891003020	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
91891003021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891003022	active site
91891003023	motif I; other site
91891003024	motif II; other site
91891003025	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
91891003026	putative active site pocket [active]
91891003027	4-fold oligomerization interface [polypeptide binding]; other site
91891003028	metal binding residues [ion binding]; metal-binding site
91891003029	3-fold/trimer interface [polypeptide binding]; other site
91891003030	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
91891003031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
91891003032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003033	homodimer interface [polypeptide binding]; other site
91891003034	catalytic residue [active]
91891003035	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
91891003036	histidinol dehydrogenase; Region: hisD; TIGR00069
91891003037	NAD binding site [chemical binding]; other site
91891003038	dimerization interface [polypeptide binding]; other site
91891003039	product binding site; other site
91891003040	substrate binding site [chemical binding]; other site
91891003041	zinc binding site [ion binding]; other site
91891003042	catalytic residues [active]
91891003043	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
91891003044	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
91891003045	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
91891003046	Trp repressor protein; Region: Trp_repressor; cl17266
91891003047	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
91891003048	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
91891003049	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
91891003050	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
91891003051	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891003052	active site
91891003053	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
91891003054	DNA-binding site [nucleotide binding]; DNA binding site
91891003055	RNA-binding motif; other site
91891003056	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
91891003057	30S subunit binding site; other site
91891003058	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
91891003059	putative deacylase active site [active]
91891003060	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
91891003061	MarR family; Region: MarR_2; pfam12802
91891003062	MarR family; Region: MarR_2; cl17246
91891003063	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
91891003064	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
91891003065	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
91891003066	LysE type translocator; Region: LysE; cl00565
91891003067	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
91891003068	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891003069	Coenzyme A binding pocket [chemical binding]; other site
91891003070	Predicted ATPase [General function prediction only]; Region: COG3911
91891003071	AAA domain; Region: AAA_28; pfam13521
91891003072	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891003073	GIY-YIG motif/motif A; other site
91891003074	putative active site [active]
91891003075	putative metal binding site [ion binding]; other site
91891003076	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
91891003077	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
91891003078	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
91891003079	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407
91891003080	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
91891003081	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
91891003082	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
91891003083	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891003084	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
91891003085	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
91891003086	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12619
91891003087	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
91891003088	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12628
91891003089	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
91891003090	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
91891003091	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
91891003092	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
91891003093	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
91891003094	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
91891003095	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
91891003096	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
91891003097	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
91891003098	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
91891003099	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
91891003100	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
91891003101	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
91891003102	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
91891003103	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12701
91891003104	Flagellar L-ring protein; Region: FlgH; pfam02107
91891003105	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
91891003106	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
91891003107	Rod binding protein; Region: Rod-binding; cl01626
91891003108	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12710
91891003109	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
91891003110	flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715
91891003111	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
91891003112	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
91891003113	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
91891003114	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
91891003115	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
91891003116	active site
91891003117	nucleophile elbow; other site
91891003118	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
91891003119	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
91891003120	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
91891003121	transmembrane helices; other site
91891003122	TrkA-C domain; Region: TrkA_C; pfam02080
91891003123	TrkA-C domain; Region: TrkA_C; pfam02080
91891003124	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
91891003125	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
91891003126	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
91891003127	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
91891003128	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891003129	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
91891003130	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891003131	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891003132	GIY-YIG motif/motif A; other site
91891003133	putative active site [active]
91891003134	putative metal binding site [ion binding]; other site
91891003135	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
91891003136	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891003137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891003138	Walker A/P-loop; other site
91891003139	ATP binding site [chemical binding]; other site
91891003140	Q-loop/lid; other site
91891003141	ABC transporter signature motif; other site
91891003142	Walker B; other site
91891003143	D-loop; other site
91891003144	H-loop/switch region; other site
91891003145	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
91891003146	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
91891003147	malate dehydrogenase; Provisional; Region: PRK13529
91891003148	Malic enzyme, N-terminal domain; Region: malic; pfam00390
91891003149	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
91891003150	NAD(P) binding site [chemical binding]; other site
91891003151	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
91891003152	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891003153	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
91891003154	Peptidase family M23; Region: Peptidase_M23; pfam01551
91891003155	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
91891003156	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
91891003157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
91891003158	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
91891003159	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
91891003160	DNA binding residues [nucleotide binding]
91891003161	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
91891003162	hypothetical protein; Validated; Region: PRK00110
91891003163	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
91891003164	active site
91891003165	putative DNA-binding cleft [nucleotide binding]; other site
91891003166	dimer interface [polypeptide binding]; other site
91891003167	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
91891003168	RuvA N terminal domain; Region: RuvA_N; pfam01330
91891003169	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891003170	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
91891003171	sensor protein QseC; Provisional; Region: PRK10337
91891003172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891003173	dimer interface [polypeptide binding]; other site
91891003174	phosphorylation site [posttranslational modification]
91891003175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891003176	ATP binding site [chemical binding]; other site
91891003177	Mg2+ binding site [ion binding]; other site
91891003178	G-X-G motif; other site
91891003179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891003180	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
91891003181	active site
91891003182	phosphorylation site [posttranslational modification]
91891003183	intermolecular recognition site; other site
91891003184	dimerization interface [polypeptide binding]; other site
91891003185	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
91891003186	DNA binding site [nucleotide binding]
91891003187	intracellular septation protein A; Reviewed; Region: PRK00259
91891003188	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
91891003189	N-acetyl-D-glucosamine binding site [chemical binding]; other site
91891003190	catalytic residue [active]
91891003191	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891003192	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
91891003193	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891003194	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
91891003195	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891003196	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
91891003197	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
91891003198	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
91891003199	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
91891003200	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
91891003201	homodimer interface [polypeptide binding]; other site
91891003202	NADP binding site [chemical binding]; other site
91891003203	substrate binding site [chemical binding]; other site
91891003204	FimV N-terminal domain; Region: FimV_core; TIGR03505
91891003205	Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108
91891003206	heterodimer interface [polypeptide binding]; other site
91891003207	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
91891003208	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
91891003209	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
91891003210	NADH(P)-binding; Region: NAD_binding_10; pfam13460
91891003211	putative NAD(P) binding site [chemical binding]; other site
91891003212	active site
91891003213	DoxX-like family; Region: DoxX_3; pfam13781
91891003214	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
91891003215	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
91891003216	dimerization interface 3.5A [polypeptide binding]; other site
91891003217	active site
91891003218	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
91891003219	active site
91891003220	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
91891003221	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
91891003222	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003223	catalytic residue [active]
91891003224	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
91891003225	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
91891003226	substrate binding site [chemical binding]; other site
91891003227	active site
91891003228	catalytic residues [active]
91891003229	heterodimer interface [polypeptide binding]; other site
91891003230	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
91891003231	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891003232	active site
91891003233	HIGH motif; other site
91891003234	nucleotide binding site [chemical binding]; other site
91891003235	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
91891003236	KMSKS motif; other site
91891003237	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
91891003238	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
91891003239	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
91891003240	active site
91891003241	HIGH motif; other site
91891003242	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
91891003243	KMSKS motif; other site
91891003244	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
91891003245	tRNA binding surface [nucleotide binding]; other site
91891003246	anticodon binding site; other site
91891003247	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
91891003248	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
91891003249	Sulfatase; Region: Sulfatase; pfam00884
91891003250	type II secretion system protein E; Region: type_II_gspE; TIGR02533
91891003251	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
91891003252	Walker A motif; other site
91891003253	ATP binding site [chemical binding]; other site
91891003254	Walker B motif; other site
91891003255	Sporulation related domain; Region: SPOR; pfam05036
91891003256	type II secretion system protein D; Region: type_II_gspD; TIGR02517
91891003257	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
91891003258	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
91891003259	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
91891003260	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
91891003261	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
91891003262	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
91891003263	Cache domain; Region: Cache_1; pfam02743
91891003264	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
91891003265	cyclase homology domain; Region: CHD; cd07302
91891003266	nucleotidyl binding site; other site
91891003267	metal binding site [ion binding]; metal-binding site
91891003268	dimer interface [polypeptide binding]; other site
91891003269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003270	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
91891003271	putative substrate translocation pore; other site
91891003272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891003274	putative substrate translocation pore; other site
91891003275	IucA / IucC family; Region: IucA_IucC; pfam04183
91891003276	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
91891003277	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
91891003278	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
91891003279	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
91891003280	Sporulation related domain; Region: SPOR; pfam05036
91891003281	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
91891003282	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891003283	GIY-YIG motif/motif A; other site
91891003284	putative active site [active]
91891003285	putative metal binding site [ion binding]; other site
91891003286	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
91891003287	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
91891003288	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
91891003289	protein binding site [polypeptide binding]; other site
91891003290	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
91891003291	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
91891003292	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
91891003293	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
91891003294	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
91891003295	RNA binding surface [nucleotide binding]; other site
91891003296	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
91891003297	active site
91891003298	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
91891003299	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
91891003300	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891003301	FeS/SAM binding site; other site
91891003302	TRAM domain; Region: TRAM; pfam01938
91891003303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003304	putative substrate translocation pore; other site
91891003305	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891003306	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891003307	Flagellar protein FliS; Region: FliS; cl00654
91891003308	flagellar capping protein; Provisional; Region: PRK12765
91891003309	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
91891003310	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
91891003311	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
91891003312	flagellin; Provisional; Region: PRK12806
91891003313	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
91891003314	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
91891003315	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
91891003316	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
91891003317	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
91891003318	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
91891003319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
91891003320	Sporulation related domain; Region: SPOR; pfam05036
91891003321	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
91891003322	Colicin V production protein; Region: Colicin_V; pfam02674
91891003323	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
91891003324	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
91891003325	active site
91891003326	(T/H)XGH motif; other site
91891003327	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
91891003328	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
91891003329	Lipopolysaccharide-assembly; Region: LptE; cl01125
91891003330	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
91891003331	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
91891003332	HIGH motif; other site
91891003333	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
91891003334	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891003335	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891003336	active site
91891003337	KMSKS motif; other site
91891003338	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
91891003339	tRNA binding surface [nucleotide binding]; other site
91891003340	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
91891003341	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
91891003342	putative active site [active]
91891003343	catalytic triad [active]
91891003344	putative dimer interface [polypeptide binding]; other site
91891003345	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
91891003346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891003347	aldehyde dehydrogenase family 7 member; Region: PLN02315
91891003348	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
91891003349	tetrameric interface [polypeptide binding]; other site
91891003350	NAD binding site [chemical binding]; other site
91891003351	catalytic residues [active]
91891003352	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
91891003353	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
91891003354	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
91891003355	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
91891003356	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
91891003357	substrate binding site [chemical binding]; other site
91891003358	oxyanion hole (OAH) forming residues; other site
91891003359	trimer interface [polypeptide binding]; other site
91891003360	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
91891003361	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
91891003362	dimer interface [polypeptide binding]; other site
91891003363	active site
91891003364	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891003365	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891003366	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891003367	Sel1-like repeats; Region: SEL1; smart00671
91891003368	Sel1-like repeats; Region: SEL1; smart00671
91891003369	Sel1-like repeats; Region: SEL1; smart00671
91891003370	Sel1-like repeats; Region: SEL1; smart00671
91891003371	Sel1-like repeats; Region: SEL1; smart00671
91891003372	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00152
91891003373	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891003374	PAS domain; Region: PAS_9; pfam13426
91891003375	putative active site [active]
91891003376	heme pocket [chemical binding]; other site
91891003377	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891003378	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891003379	metal binding site [ion binding]; metal-binding site
91891003380	active site
91891003381	I-site; other site
91891003382	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891003383	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
91891003384	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
91891003385	type II secretion system protein J; Region: gspJ; TIGR01711
91891003386	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
91891003387	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
91891003388	Type II transport protein GspH; Region: GspH; pfam12019
91891003389	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
91891003390	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
91891003391	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
91891003392	type II secretion system protein F; Region: GspF; TIGR02120
91891003393	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
91891003394	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
91891003395	glutamine synthetase; Provisional; Region: glnA; PRK09469
91891003396	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
91891003397	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
91891003398	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
91891003399	hypothetical protein; Validated; Region: PRK02101
91891003400	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
91891003401	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
91891003402	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891003403	catalytic residue [active]
91891003404	heat shock protein 90; Provisional; Region: PRK05218
91891003405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891003406	ATP binding site [chemical binding]; other site
91891003407	Mg2+ binding site [ion binding]; other site
91891003408	G-X-G motif; other site
91891003409	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
91891003410	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
91891003411	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
91891003412	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
91891003413	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
91891003414	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
91891003415	RNA/DNA hybrid binding site [nucleotide binding]; other site
91891003416	active site
91891003417	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
91891003418	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
91891003419	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
91891003420	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
91891003421	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
91891003422	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
91891003423	POT family; Region: PTR2; cl17359
91891003424	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
91891003425	urocanate hydratase; Provisional; Region: PRK05414
91891003426	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
91891003427	active sites [active]
91891003428	tetramer interface [polypeptide binding]; other site
91891003429	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
91891003430	NAD(P) binding site [chemical binding]; other site
91891003431	catalytic residues [active]
91891003432	short chain dehydrogenase; Provisional; Region: PRK08278
91891003433	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
91891003434	NAD(P) binding site [chemical binding]; other site
91891003435	homodimer interface [polypeptide binding]; other site
91891003436	active site
91891003437	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
91891003438	RNA/DNA hybrid binding site [nucleotide binding]; other site
91891003439	active site
91891003440	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
91891003441	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
91891003442	active site
91891003443	catalytic site [active]
91891003444	substrate binding site [chemical binding]; other site
91891003445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
91891003446	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891003447	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
91891003448	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
91891003449	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
91891003450	Ligand Binding Site [chemical binding]; other site
91891003451	oxidoreductase; Region: PLN02485
91891003452	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
91891003453	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
91891003454	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891003455	GIY-YIG motif/motif A; other site
91891003456	putative active site [active]
91891003457	putative metal binding site [ion binding]; other site
91891003458	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
91891003459	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
91891003460	putative phosphate acyltransferase; Provisional; Region: PRK05331
91891003461	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
91891003462	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
91891003463	dimer interface [polypeptide binding]; other site
91891003464	active site
91891003465	CoA binding pocket [chemical binding]; other site
91891003466	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
91891003467	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
91891003468	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
91891003469	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
91891003470	NAD(P) binding site [chemical binding]; other site
91891003471	homotetramer interface [polypeptide binding]; other site
91891003472	homodimer interface [polypeptide binding]; other site
91891003473	active site
91891003474	acyl carrier protein; Provisional; Region: acpP; PRK00982
91891003475	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
91891003476	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
91891003477	dimer interface [polypeptide binding]; other site
91891003478	active site
91891003479	YceG-like family; Region: YceG; pfam02618
91891003480	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
91891003481	dimerization interface [polypeptide binding]; other site
91891003482	thymidylate kinase; Validated; Region: tmk; PRK00698
91891003483	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
91891003484	TMP-binding site; other site
91891003485	ATP-binding site [chemical binding]; other site
91891003486	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
91891003487	DNA polymerase III subunit delta'; Validated; Region: PRK08485
91891003488	PilZ domain; Region: PilZ; cl01260
91891003489	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
91891003490	active site
91891003491	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
91891003492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891003494	putative substrate translocation pore; other site
91891003495	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
91891003496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003497	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
91891003498	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
91891003499	Ligand binding site; other site
91891003500	Putative Catalytic site; other site
91891003501	DXD motif; other site
91891003502	GtrA-like protein; Region: GtrA; pfam04138
91891003503	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
91891003504	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
91891003505	Phosphotransferase enzyme family; Region: APH; pfam01636
91891003506	active site
91891003507	ATP binding site [chemical binding]; other site
91891003508	substrate binding site [chemical binding]; other site
91891003509	dimer interface [polypeptide binding]; other site
91891003510	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
91891003511	active site
91891003512	catalytic site [active]
91891003513	substrate binding site [chemical binding]; other site
91891003514	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
91891003515	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
91891003516	N-acetyl-D-glucosamine binding site [chemical binding]; other site
91891003517	catalytic residue [active]
91891003518	adenylate kinase; Reviewed; Region: adk; PRK00279
91891003519	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
91891003520	AMP-binding site [chemical binding]; other site
91891003521	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
91891003522	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
91891003523	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
91891003524	catalytic residues [active]
91891003525	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
91891003526	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
91891003527	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
91891003528	N- and C-terminal domain interface [polypeptide binding]; other site
91891003529	active site
91891003530	MgATP binding site [chemical binding]; other site
91891003531	catalytic site [active]
91891003532	metal binding site [ion binding]; metal-binding site
91891003533	glycerol binding site [chemical binding]; other site
91891003534	homotetramer interface [polypeptide binding]; other site
91891003535	homodimer interface [polypeptide binding]; other site
91891003536	FBP binding site [chemical binding]; other site
91891003537	protein IIAGlc interface [polypeptide binding]; other site
91891003538	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
91891003539	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
91891003540	dimer interface [polypeptide binding]; other site
91891003541	active site
91891003542	citrylCoA binding site [chemical binding]; other site
91891003543	NADH binding [chemical binding]; other site
91891003544	cationic pore residues; other site
91891003545	oxalacetate/citrate binding site [chemical binding]; other site
91891003546	coenzyme A binding site [chemical binding]; other site
91891003547	catalytic triad [active]
91891003548	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
91891003549	DNA gyrase subunit A; Validated; Region: PRK05560
91891003550	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
91891003551	CAP-like domain; other site
91891003552	active site
91891003553	primary dimer interface [polypeptide binding]; other site
91891003554	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
91891003555	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
91891003556	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
91891003557	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
91891003558	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
91891003559	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
91891003560	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
91891003561	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891003562	catalytic residue [active]
91891003563	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
91891003564	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
91891003565	hinge; other site
91891003566	active site
91891003567	cytidylate kinase; Provisional; Region: cmk; PRK00023
91891003568	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
91891003569	CMP-binding site; other site
91891003570	The sites determining sugar specificity; other site
91891003571	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
91891003572	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
91891003573	RNA binding site [nucleotide binding]; other site
91891003574	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
91891003575	RNA binding site [nucleotide binding]; other site
91891003576	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
91891003577	RNA binding site [nucleotide binding]; other site
91891003578	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
91891003579	RNA binding site [nucleotide binding]; other site
91891003580	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
91891003581	RNA binding site [nucleotide binding]; other site
91891003582	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
91891003583	RNA binding site [nucleotide binding]; other site
91891003584	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
91891003585	tetratricopeptide repeat protein; Provisional; Region: PRK11788
91891003586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891003587	TPR motif; other site
91891003588	binding surface
91891003589	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
91891003590	binding surface
91891003591	TPR motif; other site
91891003592	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
91891003593	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
91891003594	inhibitor-cofactor binding pocket; inhibition site
91891003595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003596	catalytic residue [active]
91891003597	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
91891003598	active site
91891003599	dimer interface [polypeptide binding]; other site
91891003600	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
91891003601	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
91891003602	active site
91891003603	nucleophile elbow; other site
91891003604	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
91891003605	classical (c) SDRs; Region: SDR_c; cd05233
91891003606	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
91891003607	NAD(P) binding site [chemical binding]; other site
91891003608	active site
91891003609	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
91891003610	Chorismate lyase; Region: Chor_lyase; cl01230
91891003611	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847
91891003612	UbiA prenyltransferase family; Region: UbiA; pfam01040
91891003613	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
91891003614	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
91891003615	FAD binding domain; Region: FAD_binding_4; pfam01565
91891003616	Berberine and berberine like; Region: BBE; pfam08031
91891003617	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
91891003618	intersubunit interface [polypeptide binding]; other site
91891003619	active site
91891003620	catalytic residue [active]
91891003621	purine nucleoside phosphorylase; Provisional; Region: PRK08202
91891003622	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
91891003623	active site
91891003624	catalytic motif [active]
91891003625	Zn binding site [ion binding]; other site
91891003626	two-component sensor protein; Provisional; Region: cpxA; PRK09470
91891003627	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
91891003628	dimerization interface [polypeptide binding]; other site
91891003629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891003630	dimer interface [polypeptide binding]; other site
91891003631	phosphorylation site [posttranslational modification]
91891003632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891003633	ATP binding site [chemical binding]; other site
91891003634	Mg2+ binding site [ion binding]; other site
91891003635	G-X-G motif; other site
91891003636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891003637	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
91891003638	active site
91891003639	phosphorylation site [posttranslational modification]
91891003640	intermolecular recognition site; other site
91891003641	dimerization interface [polypeptide binding]; other site
91891003642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
91891003643	DNA binding site [nucleotide binding]
91891003644	FOG: CBS domain [General function prediction only]; Region: COG0517
91891003645	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
91891003646	Transporter associated domain; Region: CorC_HlyC; smart01091
91891003647	metal-binding heat shock protein; Provisional; Region: PRK00016
91891003648	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
91891003649	PhoH-like protein; Region: PhoH; pfam02562
91891003650	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
91891003651	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
91891003652	active site
91891003653	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
91891003654	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
91891003655	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
91891003656	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
91891003657	active site
91891003658	HIGH motif; other site
91891003659	dimer interface [polypeptide binding]; other site
91891003660	KMSKS motif; other site
91891003661	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
91891003662	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
91891003663	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
91891003664	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
91891003665	RNA binding surface [nucleotide binding]; other site
91891003666	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
91891003667	probable active site [active]
91891003668	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
91891003669	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
91891003670	DNA binding residues [nucleotide binding]
91891003671	dimerization interface [polypeptide binding]; other site
91891003672	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
91891003673	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
91891003674	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
91891003675	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
91891003676	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
91891003677	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
91891003678	substrate binding site [chemical binding]; other site
91891003679	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891003680	putative transporter; Provisional; Region: PRK10504
91891003681	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003682	putative substrate translocation pore; other site
91891003683	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
91891003684	TRAM domain; Region: TRAM; pfam01938
91891003685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891003686	S-adenosylmethionine binding site [chemical binding]; other site
91891003687	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
91891003688	HD domain; Region: HD_4; pfam13328
91891003689	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
91891003690	synthetase active site [active]
91891003691	NTP binding site [chemical binding]; other site
91891003692	metal binding site [ion binding]; metal-binding site
91891003693	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
91891003694	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
91891003695	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
91891003696	aminotransferase; Validated; Region: PRK08175
91891003697	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
91891003698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003699	homodimer interface [polypeptide binding]; other site
91891003700	catalytic residue [active]
91891003701	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
91891003702	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
91891003703	DHH family; Region: DHH; pfam01368
91891003704	DHHA1 domain; Region: DHHA1; pfam02272
91891003705	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
91891003706	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
91891003707	FMN binding site [chemical binding]; other site
91891003708	active site
91891003709	catalytic residues [active]
91891003710	substrate binding site [chemical binding]; other site
91891003711	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104
91891003712	DEAD/DEAH box helicase; Region: DEAD; pfam00270
91891003713	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
91891003714	SEC-C motif; Region: SEC-C; pfam02810
91891003715	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
91891003716	active site
91891003717	8-oxo-dGMP binding site [chemical binding]; other site
91891003718	nudix motif; other site
91891003719	metal binding site [ion binding]; metal-binding site
91891003720	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
91891003721	hypothetical protein; Provisional; Region: PRK05287
91891003722	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
91891003723	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
91891003724	CoA-binding site [chemical binding]; other site
91891003725	ATP-binding [chemical binding]; other site
91891003726	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891003727	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
91891003728	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
91891003729	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
91891003730	inhibitor-cofactor binding pocket; inhibition site
91891003731	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003732	catalytic residue [active]
91891003733	biotin synthase; Region: bioB; TIGR00433
91891003734	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891003735	FeS/SAM binding site; other site
91891003736	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
91891003737	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
91891003738	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
91891003739	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891003740	catalytic residue [active]
91891003741	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
91891003742	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
91891003743	AAA domain; Region: AAA_26; pfam13500
91891003744	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
91891003745	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
91891003746	Uncharacterized conserved protein [Function unknown]; Region: COG2928
91891003747	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
91891003748	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
91891003749	dimer interface [polypeptide binding]; other site
91891003750	anticodon binding site; other site
91891003751	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
91891003752	homodimer interface [polypeptide binding]; other site
91891003753	motif 1; other site
91891003754	active site
91891003755	motif 2; other site
91891003756	GAD domain; Region: GAD; pfam02938
91891003757	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
91891003758	motif 3; other site
91891003759	CENP-A-nucleosome distal (CAD) centromere subunit; Region: CENP-Q; pfam13094
91891003760	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
91891003761	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
91891003762	Mechanosensitive ion channel; Region: MS_channel; pfam00924
91891003763	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
91891003764	putative DNA-binding cleft [nucleotide binding]; other site
91891003765	putative DNA clevage site; other site
91891003766	molecular lever; other site
91891003767	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
91891003768	Catalytic domain of Protein Kinases; Region: PKc; cd00180
91891003769	active site
91891003770	ATP binding site [chemical binding]; other site
91891003771	substrate binding site [chemical binding]; other site
91891003772	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
91891003773	substrate binding site [chemical binding]; other site
91891003774	activation loop (A-loop); other site
91891003775	activation loop (A-loop); other site
91891003776	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
91891003777	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
91891003778	putative DNA binding site [nucleotide binding]; other site
91891003779	putative Zn2+ binding site [ion binding]; other site
91891003780	AsnC family; Region: AsnC_trans_reg; pfam01037
91891003781	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891003782	Coenzyme A binding pocket [chemical binding]; other site
91891003783	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
91891003784	GAF domain; Region: GAF; pfam01590
91891003785	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
91891003786	cyclase homology domain; Region: CHD; cd07302
91891003787	nucleotidyl binding site; other site
91891003788	metal binding site [ion binding]; metal-binding site
91891003789	dimer interface [polypeptide binding]; other site
91891003790	Pathogenicity locus; Region: Cdd1; pfam11731
91891003791	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
91891003792	Phosphotransferase enzyme family; Region: APH; pfam01636
91891003793	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
91891003794	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
91891003795	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891003796	putative active site [active]
91891003797	GIY-YIG motif/motif A; other site
91891003798	putative metal binding site [ion binding]; other site
91891003799	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891003800	Winged helix-turn helix; Region: HTH_29; pfam13551
91891003801	Helix-turn-helix domain; Region: HTH_28; pfam13518
91891003802	Integrase core domain; Region: rve; pfam00665
91891003803	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
91891003804	Integrase core domain; Region: rve_3; pfam13683
91891003805	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891003806	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
91891003807	putative active site pocket [active]
91891003808	dimerization interface [polypeptide binding]; other site
91891003809	putative catalytic residue [active]
91891003810	Dot/Icm substrate protein; Region: SidE; pfam12252
91891003811	aminopeptidase N; Provisional; Region: pepN; PRK14015
91891003812	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
91891003813	Zn binding site [ion binding]; other site
91891003814	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
91891003815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891003816	NAD(P) binding site [chemical binding]; other site
91891003817	active site
91891003818	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891003819	putative active site [active]
91891003820	GIY-YIG motif/motif A; other site
91891003821	putative metal binding site [ion binding]; other site
91891003822	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
91891003823	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
91891003824	Coenzyme A binding pocket [chemical binding]; other site
91891003825	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
91891003826	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
91891003827	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
91891003828	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
91891003829	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
91891003830	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
91891003831	E3 interaction surface; other site
91891003832	lipoyl attachment site [posttranslational modification]; other site
91891003833	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
91891003834	E3 interaction surface; other site
91891003835	lipoyl attachment site [posttranslational modification]; other site
91891003836	e3 binding domain; Region: E3_binding; pfam02817
91891003837	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
91891003838	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
91891003839	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
91891003840	dimer interface [polypeptide binding]; other site
91891003841	TPP-binding site [chemical binding]; other site
91891003842	lipoprotein NlpI; Provisional; Region: PRK11189
91891003843	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
91891003844	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
91891003845	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
91891003846	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
91891003847	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
91891003848	Sporulation related domain; Region: SPOR; pfam05036
91891003849	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
91891003850	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
91891003851	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
91891003852	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
91891003853	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
91891003854	homodimer interface [polypeptide binding]; other site
91891003855	substrate-cofactor binding pocket; other site
91891003856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003857	catalytic residue [active]
91891003858	Protein of unknown function (DUF493); Region: DUF493; pfam04359
91891003859	lipoate-protein ligase B; Provisional; Region: PRK14342
91891003860	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
91891003861	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
91891003862	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
91891003863	active site
91891003864	LssY C-terminus; Region: LssY_C; pfam14067
91891003865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
91891003866	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
91891003867	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
91891003868	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891003869	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
91891003870	Walker A/P-loop; other site
91891003871	ATP binding site [chemical binding]; other site
91891003872	Q-loop/lid; other site
91891003873	ABC transporter signature motif; other site
91891003874	Walker B; other site
91891003875	D-loop; other site
91891003876	H-loop/switch region; other site
91891003877	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
91891003878	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891003879	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891003880	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
91891003881	Amidase; Region: Amidase; cl11426
91891003882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891003883	active site
91891003884	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
91891003885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891003886	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
91891003887	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
91891003888	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
91891003889	Walker A motif; other site
91891003890	ATP binding site [chemical binding]; other site
91891003891	Walker B motif; other site
91891003892	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
91891003893	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
91891003894	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
91891003895	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
91891003896	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
91891003897	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
91891003898	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
91891003899	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
91891003900	ligand binding site [chemical binding]; other site
91891003901	CAAX protease self-immunity; Region: Abi; pfam02517
91891003902	PEP synthetase regulatory protein; Provisional; Region: PRK05339
91891003903	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
91891003904	2-methylcitrate dehydratase; Region: prpD; TIGR02330
91891003905	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
91891003906	dimer interface [polypeptide binding]; other site
91891003907	Citrate synthase; Region: Citrate_synt; pfam00285
91891003908	active site
91891003909	citrylCoA binding site [chemical binding]; other site
91891003910	oxalacetate/citrate binding site [chemical binding]; other site
91891003911	coenzyme A binding site [chemical binding]; other site
91891003912	catalytic triad [active]
91891003913	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
91891003914	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
91891003915	Uncharacterized conserved protein [Function unknown]; Region: COG4121
91891003916	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
91891003917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003918	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
91891003919	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891003920	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
91891003921	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
91891003922	inhibitor-cofactor binding pocket; inhibition site
91891003923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891003924	catalytic residue [active]
91891003925	Rubredoxin [Energy production and conversion]; Region: COG1773
91891003926	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
91891003927	iron binding site [ion binding]; other site
91891003928	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
91891003929	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
91891003930	poly(A) polymerase; Region: pcnB; TIGR01942
91891003931	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
91891003932	active site
91891003933	NTP binding site [chemical binding]; other site
91891003934	metal binding triad [ion binding]; metal-binding site
91891003935	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
91891003936	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
91891003937	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
91891003938	catalytic center binding site [active]
91891003939	ATP binding site [chemical binding]; other site
91891003940	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
91891003941	Ligand Binding Site [chemical binding]; other site
91891003942	GTP-binding protein Der; Reviewed; Region: PRK00093
91891003943	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
91891003944	G1 box; other site
91891003945	GTP/Mg2+ binding site [chemical binding]; other site
91891003946	Switch I region; other site
91891003947	G2 box; other site
91891003948	Switch II region; other site
91891003949	G3 box; other site
91891003950	G4 box; other site
91891003951	G5 box; other site
91891003952	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
91891003953	G1 box; other site
91891003954	GTP/Mg2+ binding site [chemical binding]; other site
91891003955	Switch I region; other site
91891003956	G2 box; other site
91891003957	G3 box; other site
91891003958	Switch II region; other site
91891003959	G4 box; other site
91891003960	G5 box; other site
91891003961	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
91891003962	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
91891003963	Trp docking motif [polypeptide binding]; other site
91891003964	active site
91891003965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
91891003966	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
91891003967	histidyl-tRNA synthetase; Region: hisS; TIGR00442
91891003968	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
91891003969	dimer interface [polypeptide binding]; other site
91891003970	motif 1; other site
91891003971	active site
91891003972	motif 2; other site
91891003973	motif 3; other site
91891003974	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
91891003975	anticodon binding site; other site
91891003976	Helix-turn-helix domain; Region: HTH_25; pfam13413
91891003977	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
91891003978	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891003979	binding surface
91891003980	TPR motif; other site
91891003981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891003982	binding surface
91891003983	TPR motif; other site
91891003984	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
91891003985	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891003986	FeS/SAM binding site; other site
91891003987	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
91891003988	active site
91891003989	multimer interface [polypeptide binding]; other site
91891003990	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
91891003991	active site
91891003992	dinuclear metal binding site [ion binding]; other site
91891003993	dimerization interface [polypeptide binding]; other site
91891003994	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
91891003995	putative active site [active]
91891003996	putative metal binding site [ion binding]; other site
91891003997	septum formation inhibitor; Reviewed; Region: minC; PRK00339
91891003998	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
91891003999	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
91891004000	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
91891004001	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
91891004002	acyl-activating enzyme (AAE) consensus motif; other site
91891004003	putative AMP binding site [chemical binding]; other site
91891004004	putative active site [active]
91891004005	putative CoA binding site [chemical binding]; other site
91891004006	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
91891004007	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
91891004008	substrate binding pocket [chemical binding]; other site
91891004009	membrane-bound complex binding site; other site
91891004010	hinge residues; other site
91891004011	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
91891004012	putative active site [active]
91891004013	putative CoA binding site [chemical binding]; other site
91891004014	nudix motif; other site
91891004015	metal binding site [ion binding]; metal-binding site
91891004016	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
91891004017	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
91891004018	chorismate binding enzyme; Region: Chorismate_bind; cl10555
91891004019	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
91891004020	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
91891004021	TPP-binding site [chemical binding]; other site
91891004022	tetramer interface [polypeptide binding]; other site
91891004023	heterodimer interface [polypeptide binding]; other site
91891004024	phosphorylation loop region [posttranslational modification]
91891004025	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
91891004026	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
91891004027	alpha subunit interface [polypeptide binding]; other site
91891004028	TPP binding site [chemical binding]; other site
91891004029	heterodimer interface [polypeptide binding]; other site
91891004030	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
91891004031	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
91891004032	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
91891004033	E3 interaction surface; other site
91891004034	lipoyl attachment site [posttranslational modification]; other site
91891004035	e3 binding domain; Region: E3_binding; pfam02817
91891004036	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
91891004037	Mechanosensitive ion channel; Region: MS_channel; pfam00924
91891004038	Uncharacterized conserved protein [Function unknown]; Region: COG0398
91891004039	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
91891004040	mercuric reductase; Validated; Region: PRK06370
91891004041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
91891004042	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
91891004043	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434
91891004044	NMT1/THI5 like; Region: NMT1; pfam09084
91891004045	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
91891004046	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
91891004047	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
91891004048	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
91891004049	thiS-thiF/thiG interaction site; other site
91891004050	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
91891004051	ThiS interaction site; other site
91891004052	putative active site [active]
91891004053	tetramer interface [polypeptide binding]; other site
91891004054	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
91891004055	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
91891004056	dimer interface [polypeptide binding]; other site
91891004057	substrate binding site [chemical binding]; other site
91891004058	ATP binding site [chemical binding]; other site
91891004059	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
91891004060	thiamine phosphate binding site [chemical binding]; other site
91891004061	active site
91891004062	pyrophosphate binding site [ion binding]; other site
91891004063	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
91891004064	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
91891004065	ATP binding site [chemical binding]; other site
91891004066	substrate interface [chemical binding]; other site
91891004067	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
91891004068	active site residue [active]
91891004069	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
91891004070	active site
91891004071	Zn binding site [ion binding]; other site
91891004072	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
91891004073	TolB amino-terminal domain; Region: TolB_N; pfam04052
91891004074	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
91891004075	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
91891004076	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
91891004077	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
91891004078	TolA protein; Region: tolA_full; TIGR02794
91891004079	TolA protein; Region: tolA_full; TIGR02794
91891004080	TonB C terminal; Region: TonB_2; pfam13103
91891004081	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
91891004082	TolR protein; Region: tolR; TIGR02801
91891004083	TolQ protein; Region: tolQ; TIGR02796
91891004084	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
91891004085	active site
91891004086	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
91891004087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004088	Walker A motif; other site
91891004089	ATP binding site [chemical binding]; other site
91891004090	Walker B motif; other site
91891004091	arginine finger; other site
91891004092	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
91891004093	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
91891004094	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
91891004095	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
91891004096	DNA binding residues [nucleotide binding]
91891004097	Uncharacterized conserved protein [Function unknown]; Region: COG2938
91891004098	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
91891004099	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
91891004100	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
91891004101	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
91891004102	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
91891004103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
91891004104	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891004105	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
91891004106	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
91891004107	NAD(P) binding site [chemical binding]; other site
91891004108	catalytic residues [active]
91891004109	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
91891004110	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
91891004111	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
91891004112	putative catalytic residue [active]
91891004113	chromosome segregation protein; Provisional; Region: PRK03918
91891004114	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
91891004115	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
91891004116	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
91891004117	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
91891004118	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
91891004119	Global regulator protein family; Region: CsrA; pfam02599
91891004120	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
91891004121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
91891004122	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891004123	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
91891004124	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
91891004125	substrate binding site [chemical binding]; other site
91891004126	oxyanion hole (OAH) forming residues; other site
91891004127	trimer interface [polypeptide binding]; other site
91891004128	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
91891004129	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
91891004130	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
91891004131	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
91891004132	dimer interface [polypeptide binding]; other site
91891004133	active site
91891004134	RES domain; Region: RES; smart00953
91891004135	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
91891004136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891004137	S-adenosylmethionine binding site [chemical binding]; other site
91891004138	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
91891004139	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
91891004140	Cupin domain; Region: Cupin_2; pfam07883
91891004141	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
91891004142	nudix motif; other site
91891004143	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
91891004144	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
91891004145	putative catalytic cysteine [active]
91891004146	gamma-glutamyl kinase; Provisional; Region: PRK05429
91891004147	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
91891004148	nucleotide binding site [chemical binding]; other site
91891004149	homotetrameric interface [polypeptide binding]; other site
91891004150	putative phosphate binding site [ion binding]; other site
91891004151	putative allosteric binding site; other site
91891004152	PUA domain; Region: PUA; pfam01472
91891004153	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891004154	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
91891004155	Coenzyme A binding pocket [chemical binding]; other site
91891004156	Phosphotransferase enzyme family; Region: APH; pfam01636
91891004157	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
91891004158	Evidence 4 : Homologs of previously reported genes of unknown function
91891004159	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891004160	Evidence 4 : Homologs of previously reported genes of unknown function
91891004161	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
91891004162	DNA binding residues [nucleotide binding]
91891004163	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
91891004164	dimer interface [polypeptide binding]; other site
91891004165	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
91891004166	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
91891004167	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
91891004168	DNA binding residues [nucleotide binding]
91891004169	dimer interface [polypeptide binding]; other site
91891004170	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
91891004171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891004172	Coenzyme A binding pocket [chemical binding]; other site
91891004173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891004174	Coenzyme A binding pocket [chemical binding]; other site
91891004175	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
91891004176	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891004177	Coenzyme A binding pocket [chemical binding]; other site
91891004178	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891004179	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
91891004180	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891004181	Walker A/P-loop; other site
91891004182	ATP binding site [chemical binding]; other site
91891004183	Q-loop/lid; other site
91891004184	ABC transporter signature motif; other site
91891004185	Walker B; other site
91891004186	D-loop; other site
91891004187	H-loop/switch region; other site
91891004188	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
91891004189	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891004190	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
91891004191	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891004192	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004193	GIY-YIG motif/motif A; other site
91891004194	putative active site [active]
91891004195	putative metal binding site [ion binding]; other site
91891004196	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
91891004197	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
91891004198	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
91891004199	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
91891004200	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
91891004201	Penicillinase repressor; Region: Pencillinase_R; pfam03965
91891004202	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
91891004203	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
91891004204	Permutation of conserved domain; other site
91891004205	active site
91891004206	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
91891004207	putative hydrolase; Provisional; Region: PRK10985
91891004208	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004209	putative active site [active]
91891004210	GIY-YIG motif/motif A; other site
91891004211	putative metal binding site [ion binding]; other site
91891004212	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
91891004213	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891004214	Soluble P-type ATPase [General function prediction only]; Region: COG4087
91891004215	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
91891004216	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
91891004217	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
91891004218	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891004219	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
91891004220	NAD(P) binding site [chemical binding]; other site
91891004221	active site
91891004222	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
91891004223	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
91891004224	dimer interface [polypeptide binding]; other site
91891004225	active site
91891004226	CoA binding pocket [chemical binding]; other site
91891004227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
91891004228	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
91891004229	putative ADP-binding pocket [chemical binding]; other site
91891004230	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
91891004231	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
91891004232	FAD binding domain; Region: FAD_binding_4; pfam01565
91891004233	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
91891004234	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891004235	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
91891004236	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
91891004237	active site
91891004238	catalytic site [active]
91891004239	tetramer interface [polypeptide binding]; other site
91891004240	enterobactin exporter EntS; Provisional; Region: PRK10489
91891004241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891004242	putative substrate translocation pore; other site
91891004243	Predicted membrane protein [Function unknown]; Region: COG2119
91891004244	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
91891004245	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
91891004246	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
91891004247	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
91891004248	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
91891004249	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
91891004250	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891004251	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891004252	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891004253	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
91891004254	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
91891004255	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
91891004256	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891004257	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
91891004258	threonine synthase; Validated; Region: PRK09225
91891004259	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891004260	catalytic residue [active]
91891004261	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891004262	Dot/Icm substrate protein; Region: SidE; pfam12252
91891004263	YceI-like domain; Region: YceI; pfam04264
91891004264	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
91891004265	YceI-like domain; Region: YceI; smart00867
91891004266	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
91891004267	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
91891004268	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
91891004269	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
91891004270	PYR/PP interface [polypeptide binding]; other site
91891004271	dimer interface [polypeptide binding]; other site
91891004272	TPP binding site [chemical binding]; other site
91891004273	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
91891004274	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
91891004275	TPP-binding site; other site
91891004276	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
91891004277	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
91891004278	substrate binding site [chemical binding]; other site
91891004279	ATP binding site [chemical binding]; other site
91891004280	KduI/IolB family; Region: KduI; pfam04962
91891004281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
91891004282	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
91891004283	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
91891004284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891004285	putative substrate translocation pore; other site
91891004286	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
91891004287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891004288	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
91891004289	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
91891004290	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
91891004291	active site
91891004292	Zn binding site [ion binding]; other site
91891004293	ATP-grasp domain; Region: ATP-grasp_4; cl17255
91891004294	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
91891004295	Amidinotransferase; Region: Amidinotransf; cl12043
91891004296	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
91891004297	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
91891004298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
91891004299	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891004300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891004301	putative substrate translocation pore; other site
91891004302	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
91891004303	Transglycosylase; Region: Transgly; pfam00912
91891004304	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
91891004305	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
91891004306	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
91891004307	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
91891004308	MG2 domain; Region: A2M_N; pfam01835
91891004309	Alpha-2-macroglobulin family; Region: A2M; pfam00207
91891004310	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
91891004311	surface patch; other site
91891004312	thioester region; other site
91891004313	specificity defining residues; other site
91891004314	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
91891004315	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
91891004316	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
91891004317	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
91891004318	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
91891004319	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
91891004320	active site
91891004321	catalytic site [active]
91891004322	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
91891004323	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
91891004324	active site
91891004325	substrate binding site [chemical binding]; other site
91891004326	cosubstrate binding site; other site
91891004327	catalytic site [active]
91891004328	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
91891004329	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
91891004330	ATP-grasp domain; Region: ATP-grasp_4; cl17255
91891004331	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
91891004332	amidophosphoribosyltransferase; Provisional; Region: PRK09246
91891004333	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
91891004334	active site
91891004335	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891004336	active site
91891004337	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
91891004338	ATP binding site [chemical binding]; other site
91891004339	active site
91891004340	substrate binding site [chemical binding]; other site
91891004341	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
91891004342	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
91891004343	putative active site [active]
91891004344	catalytic triad [active]
91891004345	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
91891004346	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
91891004347	dimerization interface [polypeptide binding]; other site
91891004348	putative ATP binding site [chemical binding]; other site
91891004349	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
91891004350	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
91891004351	dimerization interface [polypeptide binding]; other site
91891004352	ATP binding site [chemical binding]; other site
91891004353	Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824
91891004354	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
91891004355	dimerization interface [polypeptide binding]; other site
91891004356	ATP binding site [chemical binding]; other site
91891004357	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
91891004358	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
91891004359	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
91891004360	DsbD alpha interface [polypeptide binding]; other site
91891004361	catalytic residues [active]
91891004362	short chain dehydrogenase; Provisional; Region: PRK05993
91891004363	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
91891004364	NADP binding site [chemical binding]; other site
91891004365	active site
91891004366	steroid binding site; other site
91891004367	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
91891004368	aconitate hydratase; Validated; Region: PRK09277
91891004369	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
91891004370	substrate binding site [chemical binding]; other site
91891004371	ligand binding site [chemical binding]; other site
91891004372	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
91891004373	substrate binding site [chemical binding]; other site
91891004374	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
91891004375	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
91891004376	Proline dehydrogenase; Region: Pro_dh; pfam01619
91891004377	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
91891004378	Glutamate binding site [chemical binding]; other site
91891004379	NAD binding site [chemical binding]; other site
91891004380	catalytic residues [active]
91891004381	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
91891004382	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
91891004383	ProQ/FINO family; Region: ProQ; pfam04352
91891004384	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
91891004385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891004386	S-adenosylmethionine binding site [chemical binding]; other site
91891004387	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
91891004388	ligand binding site [chemical binding]; other site
91891004389	active site
91891004390	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
91891004391	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
91891004392	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
91891004393	active site
91891004394	DNA binding site [nucleotide binding]
91891004395	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
91891004396	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
91891004397	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
91891004398	Catalytic site [active]
91891004399	hypothetical protein; Provisional; Region: PRK07338
91891004400	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
91891004401	metal binding site [ion binding]; metal-binding site
91891004402	dimer interface [polypeptide binding]; other site
91891004403	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
91891004404	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
91891004405	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
91891004406	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
91891004407	NAD(P) binding site [chemical binding]; other site
91891004408	catalytic residues [active]
91891004409	succinylarginine dihydrolase; Provisional; Region: PRK13281
91891004410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891004411	Cytochrome c; Region: Cytochrom_C; cl11414
91891004412	ribosome recycling factor; Reviewed; Region: frr; PRK00083
91891004413	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
91891004414	hinge region; other site
91891004415	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
91891004416	putative nucleotide binding site [chemical binding]; other site
91891004417	uridine monophosphate binding site [chemical binding]; other site
91891004418	homohexameric interface [polypeptide binding]; other site
91891004419	elongation factor Ts; Provisional; Region: tsf; PRK09377
91891004420	UBA/TS-N domain; Region: UBA; pfam00627
91891004421	Elongation factor TS; Region: EF_TS; pfam00889
91891004422	Elongation factor TS; Region: EF_TS; pfam00889
91891004423	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
91891004424	rRNA interaction site [nucleotide binding]; other site
91891004425	S8 interaction site; other site
91891004426	putative laminin-1 binding site; other site
91891004427	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
91891004428	dimer interface [polypeptide binding]; other site
91891004429	Evidence 5 : No homology to any previously reported sequences
91891004430	SET domain; Region: SET; pfam00856
91891004431	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891004432	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891004433	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
91891004434	active site
91891004435	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
91891004436	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
91891004437	metal binding triad; other site
91891004438	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
91891004439	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
91891004440	Zn2+ binding site [ion binding]; other site
91891004441	Mg2+ binding site [ion binding]; other site
91891004442	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
91891004443	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
91891004444	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
91891004445	nucleoside/Zn binding site; other site
91891004446	dimer interface [polypeptide binding]; other site
91891004447	catalytic motif [active]
91891004448	GMP synthase; Reviewed; Region: guaA; PRK00074
91891004449	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
91891004450	AMP/PPi binding site [chemical binding]; other site
91891004451	candidate oxyanion hole; other site
91891004452	catalytic triad [active]
91891004453	potential glutamine specificity residues [chemical binding]; other site
91891004454	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
91891004455	ATP Binding subdomain [chemical binding]; other site
91891004456	Ligand Binding sites [chemical binding]; other site
91891004457	Dimerization subdomain; other site
91891004458	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
91891004459	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
91891004460	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
91891004461	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
91891004462	active site
91891004463	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
91891004464	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
91891004465	Switch I; other site
91891004466	Switch II; other site
91891004467	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
91891004468	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
91891004469	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
91891004470	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
91891004471	active site
91891004472	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
91891004473	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891004474	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
91891004475	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
91891004476	Walker A/P-loop; other site
91891004477	ATP binding site [chemical binding]; other site
91891004478	Q-loop/lid; other site
91891004479	ABC transporter signature motif; other site
91891004480	Walker B; other site
91891004481	D-loop; other site
91891004482	H-loop/switch region; other site
91891004483	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
91891004484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891004485	dimer interface [polypeptide binding]; other site
91891004486	conserved gate region; other site
91891004487	putative PBP binding loops; other site
91891004488	ABC-ATPase subunit interface; other site
91891004489	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
91891004490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891004491	dimer interface [polypeptide binding]; other site
91891004492	conserved gate region; other site
91891004493	putative PBP binding loops; other site
91891004494	ABC-ATPase subunit interface; other site
91891004495	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
91891004496	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
91891004497	NAD(P) binding site [chemical binding]; other site
91891004498	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
91891004499	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
91891004500	Cl- selectivity filter; other site
91891004501	Cl- binding residues [ion binding]; other site
91891004502	pore gating glutamate residue; other site
91891004503	dimer interface [polypeptide binding]; other site
91891004504	H+/Cl- coupling transport residue; other site
91891004505	anthranilate synthase; Provisional; Region: PRK13566
91891004506	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
91891004507	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
91891004508	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
91891004509	glutamine binding [chemical binding]; other site
91891004510	catalytic triad [active]
91891004511	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
91891004512	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
91891004513	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
91891004514	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
91891004515	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
91891004516	GatB domain; Region: GatB_Yqey; smart00845
91891004517	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891004518	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891004519	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891004520	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004521	putative active site [active]
91891004522	GIY-YIG motif/motif A; other site
91891004523	putative metal binding site [ion binding]; other site
91891004524	Autotransporter beta-domain; Region: Autotransporter; smart00869
91891004525	CHASE2 domain; Region: CHASE2; pfam05226
91891004526	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
91891004527	cyclase homology domain; Region: CHD; cd07302
91891004528	nucleotidyl binding site; other site
91891004529	metal binding site [ion binding]; metal-binding site
91891004530	dimer interface [polypeptide binding]; other site
91891004531	FecR protein; Region: FecR; pfam04773
91891004532	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
91891004533	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
91891004534	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
91891004535	trimerization site [polypeptide binding]; other site
91891004536	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
91891004537	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
91891004538	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891004539	catalytic residue [active]
91891004540	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
91891004541	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
91891004542	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
91891004543	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
91891004544	active site
91891004545	dimerization interface [polypeptide binding]; other site
91891004546	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
91891004547	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
91891004548	tandem repeat interface [polypeptide binding]; other site
91891004549	oligomer interface [polypeptide binding]; other site
91891004550	active site residues [active]
91891004551	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
91891004552	Clp amino terminal domain; Region: Clp_N; pfam02861
91891004553	Clp amino terminal domain; Region: Clp_N; pfam02861
91891004554	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004555	Walker A motif; other site
91891004556	ATP binding site [chemical binding]; other site
91891004557	Walker B motif; other site
91891004558	arginine finger; other site
91891004559	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
91891004560	primary dimer interface [polypeptide binding]; other site
91891004561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004562	Walker A motif; other site
91891004563	ATP binding site [chemical binding]; other site
91891004564	Walker B motif; other site
91891004565	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
91891004566	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
91891004567	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
91891004568	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
91891004569	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
91891004570	TIGR02099 family protein; Region: TIGR02099
91891004571	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
91891004572	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
91891004573	Flagellar FliJ protein; Region: FliJ; pfam02050
91891004574	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
91891004575	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
91891004576	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
91891004577	Walker A motif/ATP binding site; other site
91891004578	Walker B motif; other site
91891004579	Flagellar assembly protein FliH; Region: FliH; pfam02108
91891004580	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
91891004581	FliG C-terminal domain; Region: FliG_C; pfam01706
91891004582	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
91891004583	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
91891004584	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
91891004585	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
91891004586	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
91891004587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891004588	active site
91891004589	phosphorylation site [posttranslational modification]
91891004590	intermolecular recognition site; other site
91891004591	dimerization interface [polypeptide binding]; other site
91891004592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004593	Walker A motif; other site
91891004594	ATP binding site [chemical binding]; other site
91891004595	Walker B motif; other site
91891004596	arginine finger; other site
91891004597	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
91891004598	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
91891004599	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891004600	putative active site [active]
91891004601	heme pocket [chemical binding]; other site
91891004602	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891004603	dimer interface [polypeptide binding]; other site
91891004604	phosphorylation site [posttranslational modification]
91891004605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891004606	ATP binding site [chemical binding]; other site
91891004607	G-X-G motif; other site
91891004608	recombination factor protein RarA; Reviewed; Region: PRK13342
91891004609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004610	Walker A motif; other site
91891004611	ATP binding site [chemical binding]; other site
91891004612	Walker B motif; other site
91891004613	arginine finger; other site
91891004614	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
91891004615	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
91891004616	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
91891004617	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
91891004618	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
91891004619	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
91891004620	thioredoxin reductase; Provisional; Region: PRK10262
91891004621	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
91891004622	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
91891004623	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
91891004624	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
91891004625	active site residue [active]
91891004626	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
91891004627	rRNA binding site [nucleotide binding]; other site
91891004628	predicted 30S ribosome binding site; other site
91891004629	peptidase PmbA; Provisional; Region: PRK11040
91891004630	Predicted periplasmic protein [Function unknown]; Region: COG3698
91891004631	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
91891004632	Cupin-like domain; Region: Cupin_8; pfam13621
91891004633	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
91891004634	ATP cone domain; Region: ATP-cone; pfam03477
91891004635	ATP cone domain; Region: ATP-cone; pfam03477
91891004636	Class I ribonucleotide reductase; Region: RNR_I; cd01679
91891004637	active site
91891004638	dimer interface [polypeptide binding]; other site
91891004639	catalytic residues [active]
91891004640	effector binding site; other site
91891004641	R2 peptide binding site; other site
91891004642	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
91891004643	dimer interface [polypeptide binding]; other site
91891004644	putative radical transfer pathway; other site
91891004645	diiron center [ion binding]; other site
91891004646	tyrosyl radical; other site
91891004647	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
91891004648	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
91891004649	dimer interface [polypeptide binding]; other site
91891004650	putative anticodon binding site; other site
91891004651	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
91891004652	motif 1; other site
91891004653	active site
91891004654	motif 2; other site
91891004655	motif 3; other site
91891004656	peptide chain release factor 2; Validated; Region: prfB; PRK00578
91891004657	This domain is found in peptide chain release factors; Region: PCRF; smart00937
91891004658	RF-1 domain; Region: RF-1; pfam00472
91891004659	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
91891004660	flagellar motor protein MotD; Reviewed; Region: PRK09038
91891004661	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
91891004662	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891004663	ligand binding site [chemical binding]; other site
91891004664	flagellar motor protein; Reviewed; Region: motC; PRK09109
91891004665	flagellar motor protein MotA; Validated; Region: PRK08124
91891004666	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
91891004667	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
91891004668	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
91891004669	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
91891004670	DNA binding residues [nucleotide binding]
91891004671	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
91891004672	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
91891004673	P-loop; other site
91891004674	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
91891004675	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
91891004676	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
91891004677	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
91891004678	FHIPEP family; Region: FHIPEP; pfam00771
91891004679	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
91891004680	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
91891004681	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
91891004682	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
91891004683	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
91891004684	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
91891004685	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
91891004686	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
91891004687	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
91891004688	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
91891004689	FAD binding domain; Region: FAD_binding_4; pfam01565
91891004690	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
91891004691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891004692	NAD(P) binding site [chemical binding]; other site
91891004693	active site
91891004694	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891004695	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891004696	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
91891004697	dimerization interface [polypeptide binding]; other site
91891004698	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
91891004699	GTPase interaction site; other site
91891004700	catalytic residue [active]
91891004701	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
91891004702	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
91891004703	motif 1; other site
91891004704	active site
91891004705	motif 2; other site
91891004706	motif 3; other site
91891004707	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
91891004708	recombination regulator RecX; Reviewed; Region: recX; PRK00117
91891004709	recombinase A; Provisional; Region: recA; PRK09354
91891004710	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
91891004711	hexamer interface [polypeptide binding]; other site
91891004712	Walker A motif; other site
91891004713	ATP binding site [chemical binding]; other site
91891004714	Walker B motif; other site
91891004715	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004716	GIY-YIG motif/motif A; other site
91891004717	putative active site [active]
91891004718	putative metal binding site [ion binding]; other site
91891004719	Competence-damaged protein; Region: CinA; pfam02464
91891004720	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
91891004721	MutS domain I; Region: MutS_I; pfam01624
91891004722	MutS domain II; Region: MutS_II; pfam05188
91891004723	MutS domain III; Region: MutS_III; pfam05192
91891004724	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
91891004725	Walker A/P-loop; other site
91891004726	ATP binding site [chemical binding]; other site
91891004727	Q-loop/lid; other site
91891004728	ABC transporter signature motif; other site
91891004729	Walker B; other site
91891004730	D-loop; other site
91891004731	H-loop/switch region; other site
91891004732	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
91891004733	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
91891004734	Surface antigen; Region: Bac_surface_Ag; pfam01103
91891004735	Family of unknown function (DUF490); Region: DUF490; pfam04357
91891004736	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
91891004737	dimer interface [polypeptide binding]; other site
91891004738	active site
91891004739	Schiff base residues; other site
91891004740	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
91891004741	bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961
91891004742	AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259
91891004743	putative catalytic residues [active]
91891004744	putative nucleotide binding site [chemical binding]; other site
91891004745	putative aspartate binding site [chemical binding]; other site
91891004746	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935
91891004747	ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920
91891004748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840
91891004749	active site
91891004750	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
91891004751	substrate binding site [chemical binding]; other site
91891004752	catalytic residues [active]
91891004753	dimer interface [polypeptide binding]; other site
91891004754	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
91891004755	Part of AAA domain; Region: AAA_19; pfam13245
91891004756	Family description; Region: UvrD_C_2; pfam13538
91891004757	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
91891004758	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
91891004759	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
91891004760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891004761	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
91891004762	dimerization interface [polypeptide binding]; other site
91891004763	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891004764	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891004765	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891004766	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004767	putative active site [active]
91891004768	GIY-YIG motif/motif A; other site
91891004769	putative metal binding site [ion binding]; other site
91891004770	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
91891004771	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891004772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891004773	putative substrate translocation pore; other site
91891004774	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
91891004775	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
91891004776	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
91891004777	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891004778	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
91891004779	Walker A/P-loop; other site
91891004780	ATP binding site [chemical binding]; other site
91891004781	Q-loop/lid; other site
91891004782	ABC transporter signature motif; other site
91891004783	Walker B; other site
91891004784	D-loop; other site
91891004785	H-loop/switch region; other site
91891004786	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891004787	Coenzyme A binding pocket [chemical binding]; other site
91891004788	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
91891004789	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
91891004790	quinone interaction residues [chemical binding]; other site
91891004791	active site
91891004792	catalytic residues [active]
91891004793	FMN binding site [chemical binding]; other site
91891004794	substrate binding site [chemical binding]; other site
91891004795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891004796	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004797	GIY-YIG motif/motif A; other site
91891004798	putative active site [active]
91891004799	putative metal binding site [ion binding]; other site
91891004800	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891004801	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891004802	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891004803	isovaleryl-CoA dehydrogenase; Region: PLN02519
91891004804	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
91891004805	substrate binding site [chemical binding]; other site
91891004806	FAD binding site [chemical binding]; other site
91891004807	catalytic base [active]
91891004808	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
91891004809	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
91891004810	dimer interface [polypeptide binding]; other site
91891004811	active site
91891004812	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
91891004813	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
91891004814	enoyl-CoA hydratase; Provisional; Region: PRK05995
91891004815	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
91891004816	substrate binding site [chemical binding]; other site
91891004817	oxyanion hole (OAH) forming residues; other site
91891004818	trimer interface [polypeptide binding]; other site
91891004819	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
91891004820	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
91891004821	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
91891004822	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
91891004823	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
91891004824	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
91891004825	carboxyltransferase (CT) interaction site; other site
91891004826	biotinylation site [posttranslational modification]; other site
91891004827	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
91891004828	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
91891004829	active site
91891004830	catalytic residues [active]
91891004831	metal binding site [ion binding]; metal-binding site
91891004832	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
91891004833	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
91891004834	acyl-activating enzyme (AAE) consensus motif; other site
91891004835	putative AMP binding site [chemical binding]; other site
91891004836	putative active site [active]
91891004837	putative CoA binding site [chemical binding]; other site
91891004838	VirK protein; Region: VirK; pfam06903
91891004839	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
91891004840	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
91891004841	Walker A/P-loop; other site
91891004842	ATP binding site [chemical binding]; other site
91891004843	Q-loop/lid; other site
91891004844	ABC transporter signature motif; other site
91891004845	Walker B; other site
91891004846	D-loop; other site
91891004847	H-loop/switch region; other site
91891004848	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
91891004849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
91891004850	dimer interface [polypeptide binding]; other site
91891004851	conserved gate region; other site
91891004852	ABC-ATPase subunit interface; other site
91891004853	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
91891004854	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
91891004855	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
91891004856	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
91891004857	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891004858	active site
91891004859	motif I; other site
91891004860	motif II; other site
91891004861	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
91891004862	DALR anticodon binding domain; Region: DALR_1; pfam05746
91891004863	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
91891004864	dimer interface [polypeptide binding]; other site
91891004865	motif 1; other site
91891004866	active site
91891004867	motif 2; other site
91891004868	motif 3; other site
91891004869	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
91891004870	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
91891004871	catalytic residues [active]
91891004872	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
91891004873	Part of AAA domain; Region: AAA_19; pfam13245
91891004874	Family description; Region: UvrD_C_2; pfam13538
91891004875	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
91891004876	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
91891004877	putative active site [active]
91891004878	dimerization interface [polypeptide binding]; other site
91891004879	putative tRNAtyr binding site [nucleotide binding]; other site
91891004880	VacJ like lipoprotein; Region: VacJ; cl01073
91891004881	glutathione synthetase; Provisional; Region: PRK05246
91891004882	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
91891004883	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
91891004884	Glutamate-cysteine ligase; Region: GshA; pfam08886
91891004885	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
91891004886	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
91891004887	EamA-like transporter family; Region: EamA; pfam00892
91891004888	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
91891004889	active site residue [active]
91891004890	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
91891004891	PglZ domain; Region: PglZ; pfam08665
91891004892	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
91891004893	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
91891004894	Sugar specificity; other site
91891004895	Pyrimidine base specificity; other site
91891004896	ATP-binding site [chemical binding]; other site
91891004897	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
91891004898	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
91891004899	NAD binding site [chemical binding]; other site
91891004900	homotetramer interface [polypeptide binding]; other site
91891004901	homodimer interface [polypeptide binding]; other site
91891004902	substrate binding site [chemical binding]; other site
91891004903	active site
91891004904	periplasmic folding chaperone; Provisional; Region: PRK10788
91891004905	SurA N-terminal domain; Region: SurA_N_3; cl07813
91891004906	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
91891004907	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
91891004908	IHF dimer interface [polypeptide binding]; other site
91891004909	IHF - DNA interface [nucleotide binding]; other site
91891004910	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
91891004911	Found in ATP-dependent protease La (LON); Region: LON; smart00464
91891004912	Found in ATP-dependent protease La (LON); Region: LON; smart00464
91891004913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004914	Walker A motif; other site
91891004915	ATP binding site [chemical binding]; other site
91891004916	Walker B motif; other site
91891004917	arginine finger; other site
91891004918	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
91891004919	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
91891004920	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
91891004921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891004922	Walker A motif; other site
91891004923	ATP binding site [chemical binding]; other site
91891004924	Walker B motif; other site
91891004925	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
91891004926	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
91891004927	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
91891004928	oligomer interface [polypeptide binding]; other site
91891004929	active site residues [active]
91891004930	trigger factor; Provisional; Region: tig; PRK01490
91891004931	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
91891004932	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
91891004933	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
91891004934	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
91891004935	Int/Topo IB signature motif; other site
91891004936	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
91891004937	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891004938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891004939	ABC transporter; Region: ABC_tran_2; pfam12848
91891004940	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891004941	ribonuclease III; Reviewed; Region: rnc; PRK00102
91891004942	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
91891004943	dimerization interface [polypeptide binding]; other site
91891004944	active site
91891004945	metal binding site [ion binding]; metal-binding site
91891004946	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
91891004947	dsRNA binding site [nucleotide binding]; other site
91891004948	signal peptidase I; Provisional; Region: PRK10861
91891004949	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
91891004950	Catalytic site [active]
91891004951	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
91891004952	GTP-binding protein LepA; Provisional; Region: PRK05433
91891004953	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
91891004954	G1 box; other site
91891004955	putative GEF interaction site [polypeptide binding]; other site
91891004956	GTP/Mg2+ binding site [chemical binding]; other site
91891004957	Switch I region; other site
91891004958	G2 box; other site
91891004959	G3 box; other site
91891004960	Switch II region; other site
91891004961	G4 box; other site
91891004962	G5 box; other site
91891004963	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
91891004964	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
91891004965	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
91891004966	Transglycosylase SLT domain; Region: SLT_2; pfam13406
91891004967	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
91891004968	N-acetyl-D-glucosamine binding site [chemical binding]; other site
91891004969	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
91891004970	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
91891004971	GspL periplasmic domain; Region: GspL_C; cl14909
91891004972	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
91891004973	Sporulation related domain; Region: SPOR; cl10051
91891004974	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
91891004975	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
91891004976	Zn2+ binding site [ion binding]; other site
91891004977	Mg2+ binding site [ion binding]; other site
91891004978	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
91891004979	Trehalase; Region: Trehalase; cl17346
91891004980	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
91891004981	dimer interface [polypeptide binding]; other site
91891004982	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891004983	active site
91891004984	metal binding site [ion binding]; metal-binding site
91891004985	glutathione binding site [chemical binding]; other site
91891004986	hypothetical protein; Provisional; Region: PRK05208
91891004987	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
91891004988	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
91891004989	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891004990	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891004991	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891004992	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891004993	GIY-YIG motif/motif A; other site
91891004994	putative active site [active]
91891004995	putative metal binding site [ion binding]; other site
91891004996	acylphosphatase; Provisional; Region: PRK14451
91891004997	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
91891004998	putative active site [active]
91891004999	catalytic site [active]
91891005000	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
91891005001	PLD-like domain; Region: PLDc_2; pfam13091
91891005002	putative active site [active]
91891005003	catalytic site [active]
91891005004	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
91891005005	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
91891005006	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
91891005007	Leucine-rich repeats; other site
91891005008	Substrate binding site [chemical binding]; other site
91891005009	Leucine rich repeat; Region: LRR_8; pfam13855
91891005010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891005011	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
91891005012	putative substrate translocation pore; other site
91891005013	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
91891005014	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
91891005015	putative ion selectivity filter; other site
91891005016	putative pore gating glutamate residue; other site
91891005017	Transposase domain (DUF772); Region: DUF772; pfam05598
91891005018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
91891005019	SEC-C motif; Region: SEC-C; pfam02810
91891005020	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
91891005021	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
91891005022	TrkA-N domain; Region: TrkA_N; pfam02254
91891005023	MoxR-like ATPases [General function prediction only]; Region: COG0714
91891005024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891005025	Walker A motif; other site
91891005026	ATP binding site [chemical binding]; other site
91891005027	Walker B motif; other site
91891005028	arginine finger; other site
91891005029	Protein of unknown function DUF58; Region: DUF58; pfam01882
91891005030	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
91891005031	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
91891005032	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
91891005033	Uncharacterized conserved protein [Function unknown]; Region: COG2850
91891005034	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891005035	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
91891005036	EamA-like transporter family; Region: EamA; pfam00892
91891005037	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
91891005038	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
91891005039	nucleotide binding site [chemical binding]; other site
91891005040	Protein of unknown function, DUF462; Region: DUF462; pfam04315
91891005041	glutathionine S-transferase; Provisional; Region: PRK10542
91891005042	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
91891005043	C-terminal domain interface [polypeptide binding]; other site
91891005044	GSH binding site (G-site) [chemical binding]; other site
91891005045	dimer interface [polypeptide binding]; other site
91891005046	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
91891005047	N-terminal domain interface [polypeptide binding]; other site
91891005048	dimer interface [polypeptide binding]; other site
91891005049	substrate binding pocket (H-site) [chemical binding]; other site
91891005050	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
91891005051	Beta-lactamase; Region: Beta-lactamase; pfam00144
91891005052	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891005053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891005054	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891005055	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891005056	GIY-YIG motif/motif A; other site
91891005057	putative active site [active]
91891005058	putative metal binding site [ion binding]; other site
91891005059	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
91891005060	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
91891005061	HIGH motif; other site
91891005062	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
91891005063	active site
91891005064	KMSKS motif; other site
91891005065	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
91891005066	HAMP domain; Region: HAMP; pfam00672
91891005067	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891005068	dimer interface [polypeptide binding]; other site
91891005069	phosphorylation site [posttranslational modification]
91891005070	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891005071	ATP binding site [chemical binding]; other site
91891005072	Mg2+ binding site [ion binding]; other site
91891005073	G-X-G motif; other site
91891005074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891005075	active site
91891005076	phosphorylation site [posttranslational modification]
91891005077	intermolecular recognition site; other site
91891005078	dimerization interface [polypeptide binding]; other site
91891005079	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
91891005080	putative binding surface; other site
91891005081	active site
91891005082	6-phosphofructokinase; Provisional; Region: PRK14072
91891005083	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
91891005084	active site
91891005085	ADP/pyrophosphate binding site [chemical binding]; other site
91891005086	dimerization interface [polypeptide binding]; other site
91891005087	allosteric effector site; other site
91891005088	fructose-1,6-bisphosphate binding site; other site
91891005089	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
91891005090	Pilin (bacterial filament); Region: Pilin; pfam00114
91891005091	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
91891005092	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
91891005093	Pilin (bacterial filament); Region: Pilin; pfam00114
91891005094	BolA-like protein; Region: BolA; cl00386
91891005095	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
91891005096	Calcium-activated chloride channel; Region: Anoctamin; pfam04547
91891005097	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
91891005098	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
91891005099	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
91891005100	Ligand binding site; other site
91891005101	oligomer interface; other site
91891005102	Uncharacterized conserved protein [Function unknown]; Region: COG2835
91891005103	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
91891005104	Glycoprotease family; Region: Peptidase_M22; pfam00814
91891005105	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
91891005106	DEAD/DEAH box helicase; Region: DEAD; pfam00270
91891005107	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
91891005108	Ferredoxin [Energy production and conversion]; Region: COG1146
91891005109	4Fe-4S binding domain; Region: Fer4; cl02805
91891005110	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
91891005111	PilZ domain; Region: PilZ; pfam07238
91891005112	oxidative damage protection protein; Provisional; Region: PRK05408
91891005113	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
91891005114	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
91891005115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891005116	dimer interface [polypeptide binding]; other site
91891005117	phosphorylation site [posttranslational modification]
91891005118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891005119	ATP binding site [chemical binding]; other site
91891005120	Mg2+ binding site [ion binding]; other site
91891005121	G-X-G motif; other site
91891005122	Evidence 4 : Homologs of previously reported genes of unknown function
91891005123	Evidence 4 : Homologs of previously reported genes of unknown function
91891005124	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
91891005125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891005126	active site
91891005127	phosphorylation site [posttranslational modification]
91891005128	intermolecular recognition site; other site
91891005129	dimerization interface [polypeptide binding]; other site
91891005130	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
91891005131	DNA binding site [nucleotide binding]
91891005132	flagellar motor protein MotS; Reviewed; Region: PRK06925
91891005133	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
91891005134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891005135	S-adenosylmethionine binding site [chemical binding]; other site
91891005136	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
91891005137	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
91891005138	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
91891005139	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
91891005140	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
91891005141	active site
91891005142	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
91891005143	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
91891005144	acyl-activating enzyme (AAE) consensus motif; other site
91891005145	AMP binding site [chemical binding]; other site
91891005146	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
91891005147	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
91891005148	active site
91891005149	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
91891005150	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
91891005151	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
91891005152	Phosphopantetheine attachment site; Region: PP-binding; cl09936
91891005153	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
91891005154	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
91891005155	active site
91891005156	nucleophile elbow; other site
91891005157	Patatin phospholipase; Region: DUF3734; pfam12536
91891005158	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
91891005159	active site
91891005160	metal binding site [ion binding]; metal-binding site
91891005161	interdomain interaction site; other site
91891005162	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
91891005163	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator
91891005164	Winged helix-turn helix; Region: HTH_29; pfam13551
91891005165	Helix-turn-helix domain; Region: HTH_28; pfam13518
91891005166	Integrase core domain; Region: rve; pfam00665
91891005167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
91891005168	Integrase core domain; Region: rve_3; pfam13683
91891005169	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
91891005170	Leucine-rich repeats; other site
91891005171	Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171
91891005172	active site/putative ARF binding site [active]
91891005173	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
91891005174	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
91891005175	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
91891005176	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
91891005177	active site
91891005178	metal binding site [ion binding]; metal-binding site
91891005179	DctM-like transporters; Region: DctM; pfam06808
91891005180	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
91891005181	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
91891005182	active site
91891005183	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
91891005184	Leucine-rich repeats; other site
91891005185	Substrate binding site [chemical binding]; other site
91891005186	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891005187	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
91891005188	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891005189	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891005190	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891005191	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891005192	putative active site [active]
91891005193	GIY-YIG motif/motif A; other site
91891005194	putative metal binding site [ion binding]; other site
91891005195	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
91891005196	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
91891005197	active site
91891005198	chromosome segregation protein; Provisional; Region: PRK03918
91891005199	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
91891005200	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
91891005201	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
91891005202	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
91891005203	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
91891005204	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
91891005205	active site
91891005206	AMP binding site [chemical binding]; other site
91891005207	acyl-activating enzyme (AAE) consensus motif; other site
91891005208	Transcriptional regulators [Transcription]; Region: GntR; COG1802
91891005209	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
91891005210	DNA-binding site [nucleotide binding]; DNA binding site
91891005211	FCD domain; Region: FCD; pfam07729
91891005212	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
91891005213	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891005214	active site
91891005215	nucleotide binding site [chemical binding]; other site
91891005216	HIGH motif; other site
91891005217	KMSKS motif; other site
91891005218	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
91891005219	Cupin domain; Region: Cupin_2; pfam07883
91891005220	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
91891005221	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
91891005222	C-terminal domain interface [polypeptide binding]; other site
91891005223	GSH binding site (G-site) [chemical binding]; other site
91891005224	dimer interface [polypeptide binding]; other site
91891005225	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
91891005226	N-terminal domain interface [polypeptide binding]; other site
91891005227	putative dimer interface [polypeptide binding]; other site
91891005228	active site
91891005229	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
91891005230	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
91891005231	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
91891005232	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
91891005233	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
91891005234	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
91891005235	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
91891005236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
91891005237	TPR repeat; Region: TPR_11; pfam13414
91891005238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891005239	binding surface
91891005240	TPR motif; other site
91891005241	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
91891005242	guanine deaminase; Provisional; Region: PRK09228
91891005243	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
91891005244	active site
91891005245	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
91891005246	Toprim domain; Region: Toprim_3; pfam13362
91891005247	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
91891005248	catalytic core [active]
91891005249	RibD C-terminal domain; Region: RibD_C; cl17279
91891005250	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
91891005251	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891005252	GIY-YIG motif/motif A; other site
91891005253	putative active site [active]
91891005254	putative metal binding site [ion binding]; other site
91891005255	MAPEG family; Region: MAPEG; cl09190
91891005256	YhhN-like protein; Region: YhhN; pfam07947
91891005257	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
91891005258	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
91891005259	NodB motif; other site
91891005260	putative active site [active]
91891005261	putative catalytic site [active]
91891005262	putative Zn binding site [ion binding]; other site
91891005263	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
91891005264	MltA specific insert domain; Region: MltA; pfam03562
91891005265	3D domain; Region: 3D; pfam06725
91891005266	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
91891005267	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
91891005268	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
91891005269	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
91891005270	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891005271	homodimer interface [polypeptide binding]; other site
91891005272	catalytic residue [active]
91891005273	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
91891005274	aromatic arch; other site
91891005275	DCoH dimer interaction site [polypeptide binding]; other site
91891005276	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
91891005277	DCoH tetramer interaction site [polypeptide binding]; other site
91891005278	substrate binding site [chemical binding]; other site
91891005279	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
91891005280	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
91891005281	Protein export membrane protein; Region: SecD_SecF; pfam02355
91891005282	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
91891005283	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
91891005284	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
91891005285	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
91891005286	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
91891005287	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
91891005288	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
91891005289	ABC transporter ATPase component; Reviewed; Region: PRK11147
91891005290	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891005291	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891005292	ABC transporter; Region: ABC_tran_2; pfam12848
91891005293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
91891005294	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
91891005295	catalytic motif [active]
91891005296	Catalytic residue [active]
91891005297	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
91891005298	homotrimer interaction site [polypeptide binding]; other site
91891005299	putative active site [active]
91891005300	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
91891005301	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
91891005302	Zn2+ binding site [ion binding]; other site
91891005303	Mg2+ binding site [ion binding]; other site
91891005304	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
91891005305	synthetase active site [active]
91891005306	NTP binding site [chemical binding]; other site
91891005307	metal binding site [ion binding]; metal-binding site
91891005308	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
91891005309	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
91891005310	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
91891005311	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
91891005312	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
91891005313	catalytic site [active]
91891005314	G-X2-G-X-G-K; other site
91891005315	hypothetical protein; Provisional; Region: PRK11820
91891005316	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
91891005317	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
91891005318	ribonuclease PH; Reviewed; Region: rph; PRK00173
91891005319	Ribonuclease PH; Region: RNase_PH_bact; cd11362
91891005320	hexamer interface [polypeptide binding]; other site
91891005321	active site
91891005322	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
91891005323	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
91891005324	Walker A motif; other site
91891005325	ATP binding site [chemical binding]; other site
91891005326	Walker B motif; other site
91891005327	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
91891005328	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
91891005329	catalytic residue [active]
91891005330	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
91891005331	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
91891005332	YGGT family; Region: YGGT; pfam02325
91891005333	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
91891005334	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
91891005335	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
91891005336	active site
91891005337	catalytic residues [active]
91891005338	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
91891005339	Helix-turn-helix domain; Region: HTH_18; pfam12833
91891005340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
91891005341	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
91891005342	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
91891005343	homotetramer interface [polypeptide binding]; other site
91891005344	ligand binding site [chemical binding]; other site
91891005345	catalytic site [active]
91891005346	NAD binding site [chemical binding]; other site
91891005347	S-adenosylmethionine synthetase; Validated; Region: PRK05250
91891005348	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
91891005349	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
91891005350	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
91891005351	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
91891005352	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
91891005353	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
91891005354	catalytic site [active]
91891005355	subunit interface [polypeptide binding]; other site
91891005356	chaperone protein DnaJ; Provisional; Region: PRK10767
91891005357	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
91891005358	HSP70 interaction site [polypeptide binding]; other site
91891005359	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
91891005360	substrate binding site [polypeptide binding]; other site
91891005361	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
91891005362	Zn binding sites [ion binding]; other site
91891005363	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
91891005364	dimer interface [polypeptide binding]; other site
91891005365	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
91891005366	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
91891005367	nucleotide binding site [chemical binding]; other site
91891005368	GrpE; Region: GrpE; pfam01025
91891005369	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
91891005370	dimer interface [polypeptide binding]; other site
91891005371	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
91891005372	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
91891005373	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
91891005374	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
91891005375	substrate binding site [chemical binding]; other site
91891005376	active site
91891005377	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
91891005378	homooctamer interface [polypeptide binding]; other site
91891005379	active site
91891005380	Sporulation related domain; Region: SPOR; pfam05036
91891005381	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
91891005382	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
91891005383	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891005384	active site
91891005385	HIGH motif; other site
91891005386	nucleotide binding site [chemical binding]; other site
91891005387	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
91891005388	KMSK motif region; other site
91891005389	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
91891005390	tRNA binding surface [nucleotide binding]; other site
91891005391	anticodon binding site; other site
91891005392	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
91891005393	Domain of unknown function DUF20; Region: UPF0118; pfam01594
91891005394	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
91891005395	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
91891005396	generic binding surface II; other site
91891005397	ssDNA binding site; other site
91891005398	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891005399	ATP binding site [chemical binding]; other site
91891005400	putative Mg++ binding site [ion binding]; other site
91891005401	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891005402	nucleotide binding region [chemical binding]; other site
91891005403	ATP-binding site [chemical binding]; other site
91891005404	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
91891005405	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
91891005406	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
91891005407	ZIP Zinc transporter; Region: Zip; pfam02535
91891005408	Maf-like protein; Region: Maf; pfam02545
91891005409	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
91891005410	active site
91891005411	dimer interface [polypeptide binding]; other site
91891005412	enolase; Provisional; Region: eno; PRK00077
91891005413	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
91891005414	dimer interface [polypeptide binding]; other site
91891005415	metal binding site [ion binding]; metal-binding site
91891005416	substrate binding pocket [chemical binding]; other site
91891005417	Septum formation initiator; Region: DivIC; cl17659
91891005418	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
91891005419	mevalonate kinase; Region: mevalon_kin; TIGR00549
91891005420	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
91891005421	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
91891005422	diphosphomevalonate decarboxylase; Region: PLN02407
91891005423	diphosphomevalonate decarboxylase; Region: PLN02407
91891005424	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
91891005425	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891005426	FeS/SAM binding site; other site
91891005427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891005428	binding surface
91891005429	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
91891005430	TPR motif; other site
91891005431	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
91891005432	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891005433	ligand binding site [chemical binding]; other site
91891005434	Protein of unknown function (DUF330); Region: DUF330; cl01135
91891005435	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
91891005436	mce related protein; Region: MCE; pfam02470
91891005437	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
91891005438	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891005439	Walker A/P-loop; other site
91891005440	ATP binding site [chemical binding]; other site
91891005441	Q-loop/lid; other site
91891005442	ABC transporter signature motif; other site
91891005443	Walker B; other site
91891005444	D-loop; other site
91891005445	H-loop/switch region; other site
91891005446	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
91891005447	Permease; Region: Permease; pfam02405
91891005448	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
91891005449	active site
91891005450	ATP binding site [chemical binding]; other site
91891005451	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
91891005452	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
91891005453	homotetramer interface [polypeptide binding]; other site
91891005454	FMN binding site [chemical binding]; other site
91891005455	homodimer contacts [polypeptide binding]; other site
91891005456	putative active site [active]
91891005457	putative substrate binding site [chemical binding]; other site
91891005458	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
91891005459	homodimer interface [polypeptide binding]; other site
91891005460	catalytic residues [active]
91891005461	NAD binding site [chemical binding]; other site
91891005462	substrate binding pocket [chemical binding]; other site
91891005463	flexible flap; other site
91891005464	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
91891005465	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891005466	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
91891005467	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891005468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891005469	Walker A/P-loop; other site
91891005470	ATP binding site [chemical binding]; other site
91891005471	Q-loop/lid; other site
91891005472	ABC transporter signature motif; other site
91891005473	Walker B; other site
91891005474	D-loop; other site
91891005475	H-loop/switch region; other site
91891005476	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
91891005477	DNA-binding site [nucleotide binding]; DNA binding site
91891005478	RNA-binding motif; other site
91891005479	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
91891005480	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
91891005481	ATP binding site [chemical binding]; other site
91891005482	Mg++ binding site [ion binding]; other site
91891005483	motif III; other site
91891005484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891005485	nucleotide binding region [chemical binding]; other site
91891005486	ATP-binding site [chemical binding]; other site
91891005487	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
91891005488	putative RNA binding site [nucleotide binding]; other site
91891005489	Cation efflux family; Region: Cation_efflux; cl00316
91891005490	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
91891005491	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
91891005492	Winged helix-turn helix; Region: HTH_29; pfam13551
91891005493	Helix-turn-helix domain; Region: HTH_28; pfam13518
91891005494	Integrase core domain; Region: rve; pfam00665
91891005495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
91891005496	Integrase core domain; Region: rve_3; pfam13683
91891005497	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
91891005498	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891005499	GIY-YIG motif/motif A; other site
91891005500	putative active site [active]
91891005501	putative metal binding site [ion binding]; other site
91891005502	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891005503	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891005504	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
91891005505	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005506	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005507	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005508	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005509	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005510	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005511	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005512	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891005513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891005514	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
91891005515	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005516	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005517	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005518	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005519	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005520	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005521	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005522	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005523	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005524	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005525	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
91891005526	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
91891005527	ligand binding site [chemical binding]; other site
91891005528	K+ potassium transporter; Region: K_trans; pfam02705
91891005529	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005530	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005531	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
91891005532	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891005533	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005534	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
91891005535	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005536	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005537	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005538	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
91891005539	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005540	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005541	PAS domain S-box; Region: sensory_box; TIGR00229
91891005542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891005543	putative active site [active]
91891005544	heme pocket [chemical binding]; other site
91891005545	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891005546	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891005547	metal binding site [ion binding]; metal-binding site
91891005548	active site
91891005549	I-site; other site
91891005550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891005551	metabolite-proton symporter; Region: 2A0106; TIGR00883
91891005552	putative substrate translocation pore; other site
91891005553	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
91891005554	Protein export membrane protein; Region: SecD_SecF; cl14618
91891005555	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
91891005556	carboxyltransferase (CT) interaction site; other site
91891005557	biotinylation site [posttranslational modification]; other site
91891005558	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891005559	Outer membrane efflux protein; Region: OEP; pfam02321
91891005560	Outer membrane efflux protein; Region: OEP; pfam02321
91891005561	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
91891005562	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
91891005563	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891005564	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891005565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
91891005566	dimerization interface [polypeptide binding]; other site
91891005567	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
91891005568	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
91891005569	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
91891005570	classical (c) SDRs; Region: SDR_c; cd05233
91891005571	NAD(P) binding site [chemical binding]; other site
91891005572	active site
91891005573	F-box-like; Region: F-box-like; pfam12937
91891005574	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
91891005575	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005576	Response regulator receiver domain; Region: Response_reg; pfam00072
91891005577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891005578	active site
91891005579	phosphorylation site [posttranslational modification]
91891005580	intermolecular recognition site; other site
91891005581	dimerization interface [polypeptide binding]; other site
91891005582	PAS fold; Region: PAS_4; pfam08448
91891005583	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891005584	putative active site [active]
91891005585	heme pocket [chemical binding]; other site
91891005586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
91891005587	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891005588	dimer interface [polypeptide binding]; other site
91891005589	phosphorylation site [posttranslational modification]
91891005590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891005591	ATP binding site [chemical binding]; other site
91891005592	Mg2+ binding site [ion binding]; other site
91891005593	G-X-G motif; other site
91891005594	Response regulator receiver domain; Region: Response_reg; pfam00072
91891005595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891005596	active site
91891005597	phosphorylation site [posttranslational modification]
91891005598	intermolecular recognition site; other site
91891005599	dimerization interface [polypeptide binding]; other site
91891005600	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891005601	dimer interface [polypeptide binding]; other site
91891005602	phosphorylation site [posttranslational modification]
91891005603	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891005604	ATP binding site [chemical binding]; other site
91891005605	Mg2+ binding site [ion binding]; other site
91891005606	G-X-G motif; other site
91891005607	Ribosomal protein L19e.  L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment; Region: Ribosomal_L19e; cl00232
91891005608	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
91891005609	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
91891005610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891005611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891005612	Walker A/P-loop; other site
91891005613	ATP binding site [chemical binding]; other site
91891005614	Q-loop/lid; other site
91891005615	ABC transporter signature motif; other site
91891005616	Walker B; other site
91891005617	D-loop; other site
91891005618	H-loop/switch region; other site
91891005619	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005620	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005621	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005622	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005623	Dot/Icm substrate protein; Region: SidE; pfam12252
91891005624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891005625	S-adenosylmethionine binding site [chemical binding]; other site
91891005626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891005627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891005628	S-adenosylmethionine binding site [chemical binding]; other site
91891005629	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
91891005630	Predicted transcriptional regulator [Transcription]; Region: COG2378
91891005631	HTH domain; Region: HTH_11; pfam08279
91891005632	WYL domain; Region: WYL; pfam13280
91891005633	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
91891005634	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891005635	Coenzyme A binding pocket [chemical binding]; other site
91891005636	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
91891005637	putative dimer interface [polypeptide binding]; other site
91891005638	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891005639	PAS fold; Region: PAS_4; pfam08448
91891005640	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
91891005641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
91891005642	DNA binding residues [nucleotide binding]
91891005643	dimerization interface [polypeptide binding]; other site
91891005644	S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Region: SAM1; COG0499
91891005645	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
91891005646	NAD binding site [chemical binding]; other site
91891005647	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891005648	GIY-YIG motif/motif A; other site
91891005649	putative active site [active]
91891005650	putative metal binding site [ion binding]; other site
91891005651	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891005652	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891005653	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891005654	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
91891005655	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
91891005656	active site
91891005657	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
91891005658	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891005659	catalytic residue [active]
91891005660	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
91891005661	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891005662	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891005663	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
91891005664	N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649
91891005665	putative active site [active]
91891005666	putative substrate binding site [chemical binding]; other site
91891005667	putative cosubstrate binding site; other site
91891005668	catalytic site [active]
91891005669	C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700
91891005670	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
91891005671	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
91891005672	acyl-activating enzyme (AAE) consensus motif; other site
91891005673	AMP binding site [chemical binding]; other site
91891005674	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
91891005675	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
91891005676	PAS domain; Region: PAS; smart00091
91891005677	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
91891005678	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891005679	putative active site [active]
91891005680	heme pocket [chemical binding]; other site
91891005681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891005682	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
91891005683	dimer interface [polypeptide binding]; other site
91891005684	phosphorylation site [posttranslational modification]
91891005685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891005686	ATP binding site [chemical binding]; other site
91891005687	Mg2+ binding site [ion binding]; other site
91891005688	G-X-G motif; other site
91891005689	Response regulator receiver domain; Region: Response_reg; pfam00072
91891005690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891005691	active site
91891005692	phosphorylation site [posttranslational modification]
91891005693	intermolecular recognition site; other site
91891005694	dimerization interface [polypeptide binding]; other site
91891005695	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
91891005696	putative binding surface; other site
91891005697	active site
91891005698	PAS fold; Region: PAS_4; pfam08448
91891005699	Response regulator receiver domain; Region: Response_reg; pfam00072
91891005700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891005701	active site
91891005702	phosphorylation site [posttranslational modification]
91891005703	intermolecular recognition site; other site
91891005704	dimerization interface [polypeptide binding]; other site
91891005705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891005706	Methyltransferase domain; Region: Methyltransf_31; pfam13847
91891005707	S-adenosylmethionine binding site [chemical binding]; other site
91891005708	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
91891005709	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
91891005710	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
91891005711	active site
91891005712	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
91891005713	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
91891005714	active site
91891005715	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
91891005716	KR domain; Region: KR; pfam08659
91891005717	NADP binding site [chemical binding]; other site
91891005718	active site
91891005719	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
91891005720	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
91891005721	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
91891005722	active site
91891005723	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
91891005724	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
91891005725	KR domain; Region: KR; pfam08659
91891005726	NADP binding site [chemical binding]; other site
91891005727	active site
91891005728	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
91891005729	Condensation domain; Region: Condensation; pfam00668
91891005730	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
91891005731	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891005732	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891005733	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
91891005734	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
91891005735	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
91891005736	putative dimer interface [polypeptide binding]; other site
91891005737	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
91891005738	Sulfate transporter family; Region: Sulfate_transp; pfam00916
91891005739	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
91891005740	active site clefts [active]
91891005741	zinc binding site [ion binding]; other site
91891005742	dimer interface [polypeptide binding]; other site
91891005743	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
91891005744	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
91891005745	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
91891005746	SnoaL-like domain; Region: SnoaL_3; pfam13474
91891005747	Methyltransferase domain; Region: Methyltransf_23; pfam13489
91891005748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891005749	S-adenosylmethionine binding site [chemical binding]; other site
91891005750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891005751	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
91891005752	putative substrate translocation pore; other site
91891005753	POT family; Region: PTR2; cl17359
91891005754	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
91891005755	hypothetical protein; Reviewed; Region: PRK09588
91891005756	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
91891005757	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
91891005758	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
91891005759	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
91891005760	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
91891005761	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
91891005762	putative NAD(P) binding site [chemical binding]; other site
91891005763	dimer interface [polypeptide binding]; other site
91891005764	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
91891005765	substrate binding site [chemical binding]; other site
91891005766	Domain of unknown function (DUF4424); Region: DUF4424; pfam14415
91891005767	YARHG domain; Region: YARHG; pfam13308
91891005768	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
91891005769	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
91891005770	active site
91891005771	metal binding site [ion binding]; metal-binding site
91891005772	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891005773	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
91891005774	NAD(P) binding site [chemical binding]; other site
91891005775	active site
91891005776	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005777	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005778	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891005779	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
91891005780	iron-sulfur cluster [ion binding]; other site
91891005781	[2Fe-2S] cluster binding site [ion binding]; other site
91891005782	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
91891005783	hydrophobic ligand binding site; other site
91891005784	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
91891005785	putative trimer interface [polypeptide binding]; other site
91891005786	putative CoA binding site [chemical binding]; other site
91891005787	Sel1 repeat; Region: Sel1; pfam08238
91891005788	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891005789	Sel1-like repeats; Region: SEL1; smart00671
91891005790	Sel1 repeat; Region: Sel1; pfam08238
91891005791	Sel1-like repeats; Region: SEL1; smart00671
91891005792	Sel1-like repeats; Region: SEL1; smart00671
91891005793	Sel1-like repeats; Region: SEL1; smart00671
91891005794	GH3 auxin-responsive promoter; Region: GH3; pfam03321
91891005795	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
91891005796	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
91891005797	active site
91891005798	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
91891005799	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
91891005800	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
91891005801	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
91891005802	active site
91891005803	acyl-CoA synthetase; Validated; Region: PRK05850
91891005804	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
91891005805	acyl-activating enzyme (AAE) consensus motif; other site
91891005806	active site
91891005807	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
91891005808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
91891005809	acyl-activating enzyme (AAE) consensus motif; other site
91891005810	AMP binding site [chemical binding]; other site
91891005811	active site
91891005812	CoA binding site [chemical binding]; other site
91891005813	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
91891005814	classical (c) SDRs; Region: SDR_c; cd05233
91891005815	NAD(P) binding site [chemical binding]; other site
91891005816	active site
91891005817	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
91891005818	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
91891005819	dimer interface [polypeptide binding]; other site
91891005820	active site
91891005821	CoA binding pocket [chemical binding]; other site
91891005822	Phosphopantetheine attachment site; Region: PP-binding; cl09936
91891005823	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
91891005824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891005825	putative substrate translocation pore; other site
91891005826	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
91891005827	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
91891005828	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
91891005829	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
91891005830	Binuclear center (active site) [active]
91891005831	K-pathway; other site
91891005832	Putative proton exit pathway; other site
91891005833	Putative water exit pathway; other site
91891005834	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
91891005835	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
91891005836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891005837	Walker A/P-loop; other site
91891005838	ATP binding site [chemical binding]; other site
91891005839	Q-loop/lid; other site
91891005840	ABC transporter signature motif; other site
91891005841	Walker B; other site
91891005842	D-loop; other site
91891005843	H-loop/switch region; other site
91891005844	MAPEG family; Region: MAPEG; cl09190
91891005845	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891005846	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
91891005847	hypothetical protein; Validated; Region: PRK07198
91891005848	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
91891005849	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
91891005850	dimerization interface [polypeptide binding]; other site
91891005851	active site
91891005852	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
91891005853	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891005854	active site
91891005855	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
91891005856	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
91891005857	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
91891005858	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
91891005859	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
91891005860	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
91891005861	catalytic triad [active]
91891005862	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
91891005863	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
91891005864	putative active site [active]
91891005865	metal binding site [ion binding]; metal-binding site
91891005866	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
91891005867	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
91891005868	NAD(P) binding site [chemical binding]; other site
91891005869	catalytic residues [active]
91891005870	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
91891005871	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
91891005872	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
91891005873	hypothetical protein; Provisional; Region: PRK05409
91891005874	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
91891005875	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
91891005876	Beta-Casp domain; Region: Beta-Casp; smart01027
91891005877	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
91891005878	BON domain; Region: BON; pfam04972
91891005879	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
91891005880	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
91891005881	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
91891005882	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
91891005883	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
91891005884	dimer interaction site [polypeptide binding]; other site
91891005885	substrate-binding tunnel; other site
91891005886	active site
91891005887	catalytic site [active]
91891005888	substrate binding site [chemical binding]; other site
91891005889	phosphate acetyltransferase; Provisional; Region: PRK11890
91891005890	propionate/acetate kinase; Provisional; Region: PRK12379
91891005891	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
91891005892	nucleotide binding site [chemical binding]; other site
91891005893	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
91891005894	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
91891005895	HSP70 interaction site [polypeptide binding]; other site
91891005896	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
91891005897	substrate binding site [polypeptide binding]; other site
91891005898	dimer interface [polypeptide binding]; other site
91891005899	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
91891005900	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
91891005901	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
91891005902	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
91891005903	putative acyl-acceptor binding pocket; other site
91891005904	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
91891005905	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
91891005906	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
91891005907	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
91891005908	active site
91891005909	probable DNA repair protein; Region: TIGR03623
91891005910	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
91891005911	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
91891005912	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
91891005913	putative NAD(P) binding site [chemical binding]; other site
91891005914	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
91891005915	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891005916	GIY-YIG motif/motif A; other site
91891005917	putative active site [active]
91891005918	putative metal binding site [ion binding]; other site
91891005919	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
91891005920	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
91891005921	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
91891005922	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
91891005923	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
91891005924	putative active site [active]
91891005925	catalytic site [active]
91891005926	putative metal binding site [ion binding]; other site
91891005927	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
91891005928	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
91891005929	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
91891005930	NAD binding site [chemical binding]; other site
91891005931	Phe binding site; other site
91891005932	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
91891005933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891005934	S-adenosylmethionine binding site [chemical binding]; other site
91891005935	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
91891005936	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
91891005937	dimer interface [polypeptide binding]; other site
91891005938	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
91891005939	active site
91891005940	Fe binding site [ion binding]; other site
91891005941	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
91891005942	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
91891005943	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
91891005944	maleylacetoacetate isomerase; Region: maiA; TIGR01262
91891005945	C-terminal domain interface [polypeptide binding]; other site
91891005946	GSH binding site (G-site) [chemical binding]; other site
91891005947	putative dimer interface [polypeptide binding]; other site
91891005948	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
91891005949	dimer interface [polypeptide binding]; other site
91891005950	N-terminal domain interface [polypeptide binding]; other site
91891005951	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
91891005952	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
91891005953	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
91891005954	putative dimer interface [polypeptide binding]; other site
91891005955	putative anticodon binding site; other site
91891005956	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
91891005957	homodimer interface [polypeptide binding]; other site
91891005958	motif 1; other site
91891005959	motif 2; other site
91891005960	active site
91891005961	motif 3; other site
91891005962	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
91891005963	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
91891005964	Walker A/P-loop; other site
91891005965	ATP binding site [chemical binding]; other site
91891005966	Q-loop/lid; other site
91891005967	ABC transporter signature motif; other site
91891005968	Walker B; other site
91891005969	D-loop; other site
91891005970	H-loop/switch region; other site
91891005971	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
91891005972	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
91891005973	FtsX-like permease family; Region: FtsX; pfam02687
91891005974	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
91891005975	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
91891005976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891005977	motif II; other site
91891005978	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
91891005979	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
91891005980	RNA binding surface [nucleotide binding]; other site
91891005981	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
91891005982	active site
91891005983	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
91891005984	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
91891005985	homodimer interface [polypeptide binding]; other site
91891005986	oligonucleotide binding site [chemical binding]; other site
91891005987	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
91891005988	ATP-dependent helicase HepA; Validated; Region: PRK04914
91891005989	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891005990	ATP binding site [chemical binding]; other site
91891005991	putative Mg++ binding site [ion binding]; other site
91891005992	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891005993	nucleotide binding region [chemical binding]; other site
91891005994	ATP-binding site [chemical binding]; other site
91891005995	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891005996	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891005997	Smr domain; Region: Smr; pfam01713
91891005998	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
91891005999	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
91891006000	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
91891006001	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
91891006002	Tetramer interface [polypeptide binding]; other site
91891006003	active site
91891006004	FMN-binding site [chemical binding]; other site
91891006005	HemK family putative methylases; Region: hemK_fam; TIGR00536
91891006006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006007	S-adenosylmethionine binding site [chemical binding]; other site
91891006008	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891006009	GIY-YIG motif/motif A; other site
91891006010	putative active site [active]
91891006011	putative metal binding site [ion binding]; other site
91891006012	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
91891006013	Smr domain; Region: Smr; pfam01713
91891006014	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
91891006015	active site residue [active]
91891006016	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
91891006017	GSH binding site [chemical binding]; other site
91891006018	catalytic residues [active]
91891006019	preprotein translocase subunit SecB; Validated; Region: PRK05751
91891006020	SecA binding site; other site
91891006021	Preprotein binding site; other site
91891006022	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
91891006023	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
91891006024	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
91891006025	glutamate racemase; Provisional; Region: PRK00865
91891006026	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
91891006027	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
91891006028	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
91891006029	dihydrodipicolinate synthase; Region: dapA; TIGR00674
91891006030	dimer interface [polypeptide binding]; other site
91891006031	active site
91891006032	catalytic residue [active]
91891006033	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
91891006034	classical (c) SDRs; Region: SDR_c; cd05233
91891006035	NAD(P) binding site [chemical binding]; other site
91891006036	active site
91891006037	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
91891006038	nucleophile elbow; other site
91891006039	Patatin phospholipase; Region: DUF3734; pfam12536
91891006040	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
91891006041	flagellar motor protein MotA; Validated; Region: PRK09110
91891006042	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
91891006043	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
91891006044	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891006045	ligand binding site [chemical binding]; other site
91891006046	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
91891006047	serine transporter; Region: stp; TIGR00814
91891006048	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
91891006049	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891006050	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
91891006051	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891006052	ATP binding site [chemical binding]; other site
91891006053	Walker B motif; other site
91891006054	sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678
91891006055	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
91891006056	DNA repair protein RadA; Provisional; Region: PRK11823
91891006057	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891006058	Walker A motif; other site
91891006059	ATP binding site [chemical binding]; other site
91891006060	Walker B motif; other site
91891006061	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
91891006062	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
91891006063	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
91891006064	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
91891006065	substrate binding pocket [chemical binding]; other site
91891006066	chain length determination region; other site
91891006067	substrate-Mg2+ binding site; other site
91891006068	catalytic residues [active]
91891006069	aspartate-rich region 1; other site
91891006070	active site lid residues [active]
91891006071	aspartate-rich region 2; other site
91891006072	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
91891006073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006074	S-adenosylmethionine binding site [chemical binding]; other site
91891006075	comF family protein; Region: comF; TIGR00201
91891006076	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891006077	active site
91891006078	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
91891006079	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
91891006080	active site
91891006081	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
91891006082	protein binding site [polypeptide binding]; other site
91891006083	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
91891006084	putative substrate binding region [chemical binding]; other site
91891006085	GrpE; Region: GrpE; pfam01025
91891006086	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
91891006087	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
91891006088	tRNA; other site
91891006089	putative tRNA binding site [nucleotide binding]; other site
91891006090	putative NADP binding site [chemical binding]; other site
91891006091	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
91891006092	peptide chain release factor 1; Validated; Region: prfA; PRK00591
91891006093	This domain is found in peptide chain release factors; Region: PCRF; smart00937
91891006094	RF-1 domain; Region: RF-1; pfam00472
91891006095	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
91891006096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006097	S-adenosylmethionine binding site [chemical binding]; other site
91891006098	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
91891006099	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
91891006100	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
91891006101	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
91891006102	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
91891006103	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
91891006104	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
91891006105	putative metal binding site [ion binding]; other site
91891006106	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
91891006107	HSP70 interaction site [polypeptide binding]; other site
91891006108	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
91891006109	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
91891006110	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
91891006111	active site
91891006112	catalytic triad [active]
91891006113	oxyanion hole [active]
91891006114	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
91891006115	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
91891006116	ATP binding site [chemical binding]; other site
91891006117	Mg++ binding site [ion binding]; other site
91891006118	motif III; other site
91891006119	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
91891006120	nucleotide binding region [chemical binding]; other site
91891006121	ATP-binding site [chemical binding]; other site
91891006122	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
91891006123	putative RNA binding site [nucleotide binding]; other site
91891006124	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
91891006125	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
91891006126	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
91891006127	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
91891006128	active site
91891006129	FMN binding site [chemical binding]; other site
91891006130	2,4-decadienoyl-CoA binding site; other site
91891006131	catalytic residue [active]
91891006132	4Fe-4S cluster binding site [ion binding]; other site
91891006133	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
91891006134	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
91891006135	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
91891006136	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
91891006137	E-class dimer interface [polypeptide binding]; other site
91891006138	P-class dimer interface [polypeptide binding]; other site
91891006139	active site
91891006140	Cu2+ binding site [ion binding]; other site
91891006141	Zn2+ binding site [ion binding]; other site
91891006142	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
91891006143	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
91891006144	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
91891006145	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
91891006146	dimer interface [polypeptide binding]; other site
91891006147	decamer (pentamer of dimers) interface [polypeptide binding]; other site
91891006148	catalytic triad [active]
91891006149	peroxidatic and resolving cysteines [active]
91891006150	malate dehydrogenase; Provisional; Region: PRK05442
91891006151	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
91891006152	NAD(P) binding site [chemical binding]; other site
91891006153	dimer interface [polypeptide binding]; other site
91891006154	malate binding site [chemical binding]; other site
91891006155	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
91891006156	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
91891006157	dimer interface [polypeptide binding]; other site
91891006158	ADP-ribose binding site [chemical binding]; other site
91891006159	active site
91891006160	nudix motif; other site
91891006161	metal binding site [ion binding]; metal-binding site
91891006162	HemN family oxidoreductase; Provisional; Region: PRK05660
91891006163	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
91891006164	FeS/SAM binding site; other site
91891006165	HemN C-terminal domain; Region: HemN_C; pfam06969
91891006166	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
91891006167	Amidase; Region: Amidase; pfam01425
91891006168	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
91891006169	UGMP family protein; Validated; Region: PRK09604
91891006170	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
91891006171	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
91891006172	Yqey-like protein; Region: YqeY; pfam09424
91891006173	DNA primase; Validated; Region: dnaG; PRK05667
91891006174	CHC2 zinc finger; Region: zf-CHC2; pfam01807
91891006175	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
91891006176	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
91891006177	active site
91891006178	metal binding site [ion binding]; metal-binding site
91891006179	interdomain interaction site; other site
91891006180	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
91891006181	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
91891006182	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
91891006183	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
91891006184	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
91891006185	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
91891006186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
91891006187	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
91891006188	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
91891006189	DNA binding residues [nucleotide binding]
91891006190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
91891006191	active site
91891006192	DNA binding site [nucleotide binding]
91891006193	Int/Topo IB signature motif; other site
91891006194	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
91891006195	active site
91891006196	homodimer interface [polypeptide binding]; other site
91891006197	SAM binding site [chemical binding]; other site
91891006198	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
91891006199	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
91891006200	POT family; Region: PTR2; cl17359
91891006201	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
91891006202	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891006203	non-specific DNA binding site [nucleotide binding]; other site
91891006204	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
91891006205	salt bridge; other site
91891006206	sequence-specific DNA binding site [nucleotide binding]; other site
91891006207	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
91891006208	Catalytic site [active]
91891006209	PaRep2b protein; Region: PaRep2b; pfam07775
91891006210	Global regulator protein family; Region: CsrA; pfam02599
91891006211	conjugal transfer ATPase TrbB; Provisional; Region: PRK13894
91891006212	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
91891006213	ATP binding site [chemical binding]; other site
91891006214	Walker A motif; other site
91891006215	hexamer interface [polypeptide binding]; other site
91891006216	Walker B motif; other site
91891006217	TrbC/VIRB2 family; Region: TrbC; cl01583
91891006218	conjugal transfer protein TrbD; Provisional; Region: PRK13823
91891006219	conjugal transfer protein TrbE; Provisional; Region: PRK13891
91891006220	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
91891006221	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
91891006222	VirB8 protein; Region: VirB8; cl01500
91891006223	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
91891006224	VirB7 interaction site; other site
91891006225	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
91891006226	conjugal transfer protein TrbI; Provisional; Region: PRK13881
91891006227	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
91891006228	conjugal transfer protein TrbJ; Provisional; Region: PRK13879
91891006229	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
91891006230	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
91891006231	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891006232	Walker A motif; other site
91891006233	ATP binding site [chemical binding]; other site
91891006234	Walker B motif; other site
91891006235	conjugal transfer peptidase TraF; Provisional; Region: PRK13884
91891006236	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
91891006237	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
91891006238	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
91891006239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
91891006240	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
91891006241	active site
91891006242	metal binding site [ion binding]; metal-binding site
91891006243	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
91891006244	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
91891006245	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
91891006246	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
91891006247	P-loop; other site
91891006248	Transcriptional activator TraM; Region: Activator-TraM; cl11943
91891006249	Evidence 7 : Gene remnant; Product type e : enzyme
91891006250	Evidence 7 : Gene remnant; Product type e : enzyme
91891006251	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
91891006252	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
91891006253	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
91891006254	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
91891006255	multiple promoter invertase; Provisional; Region: mpi; PRK13413
91891006256	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
91891006257	catalytic residues [active]
91891006258	catalytic nucleophile [active]
91891006259	Presynaptic Site I dimer interface [polypeptide binding]; other site
91891006260	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
91891006261	Synaptic Flat tetramer interface [polypeptide binding]; other site
91891006262	Synaptic Site I dimer interface [polypeptide binding]; other site
91891006263	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
91891006264	DNA-binding interface [nucleotide binding]; DNA binding site
91891006265	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
91891006266	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
91891006267	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
91891006268	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
91891006269	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
91891006270	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
91891006271	Evidence 4 : Homologs of previously reported genes of unknown function
91891006272	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
91891006273	CsbD-like; Region: CsbD; cl17424
91891006274	PRC-barrel domain; Region: PRC; pfam05239
91891006275	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
91891006276	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
91891006277	acetylornithine deacetylase; Provisional; Region: PRK07522
91891006278	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
91891006279	metal binding site [ion binding]; metal-binding site
91891006280	putative dimer interface [polypeptide binding]; other site
91891006281	Fatty acid desaturase; Region: FA_desaturase; pfam00487
91891006282	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
91891006283	Di-iron ligands [ion binding]; other site
91891006284	Transposase; Region: DDE_Tnp_ISL3; pfam01610
91891006285	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
91891006286	transmembrane helices; other site
91891006287	TrkA-C domain; Region: TrkA_C; pfam02080
91891006288	TrkA-C domain; Region: TrkA_C; pfam02080
91891006289	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
91891006290	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
91891006291	Domain of unknown function (DUF389); Region: DUF389; cl00781
91891006292	Transposase; Region: HTH_Tnp_IS630; pfam01710
91891006293	DDE superfamily endonuclease; Region: DDE_3; pfam13358
91891006294	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
91891006295	Fatty acid desaturase; Region: FA_desaturase; pfam00487
91891006296	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
91891006297	putative di-iron ligands [ion binding]; other site
91891006298	putative transporter; Provisional; Region: PRK10504
91891006299	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
91891006300	Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131
91891006301	active site
91891006302	Zn binding site [ion binding]; other site
91891006303	Domain of unknown function (DUF927); Region: DUF927; pfam06048
91891006304	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
91891006305	Helix-turn-helix domain; Region: HTH_17; cl17695
91891006306	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
91891006307	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
91891006308	active site
91891006309	metal binding site [ion binding]; metal-binding site
91891006310	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
91891006311	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
91891006312	active site
91891006313	DNA binding site [nucleotide binding]
91891006314	Int/Topo IB signature motif; other site
91891006315	Cupin domain; Region: Cupin_2; cl17218
91891006316	hypothetical protein; Provisional; Region: PRK07206
91891006317	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
91891006318	H+ Antiporter protein; Region: 2A0121; TIGR00900
91891006319	Evidence 7 : Gene remnant; Product type e : enzyme
91891006320	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
91891006321	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
91891006322	active site
91891006323	SAM binding site [chemical binding]; other site
91891006324	homodimer interface [polypeptide binding]; other site
91891006325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006326	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891006327	putative substrate translocation pore; other site
91891006328	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891006329	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891006330	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
91891006331	substrate binding pocket [chemical binding]; other site
91891006332	dimerization interface [polypeptide binding]; other site
91891006333	HipA-like C-terminal domain; Region: HipA_C; pfam07804
91891006334	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891006335	SNARE domain; Region: SNARE; pfam05739
91891006336	flanking leucine-zipper layers; other site
91891006337	zero layer; other site
91891006338	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891006339	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891006340	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
91891006341	putative effector binding pocket; other site
91891006342	dimerization interface [polypeptide binding]; other site
91891006343	potassium uptake protein; Region: kup; TIGR00794
91891006344	K+ potassium transporter; Region: K_trans; pfam02705
91891006345	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854
91891006346	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
91891006347	Ligand Binding Site [chemical binding]; other site
91891006348	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
91891006349	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
91891006350	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891006351	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
91891006352	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
91891006353	Soluble P-type ATPase [General function prediction only]; Region: COG4087
91891006354	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
91891006355	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
91891006356	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
91891006357	TrkA-N domain; Region: TrkA_N; pfam02254
91891006358	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
91891006359	Ligand Binding Site [chemical binding]; other site
91891006360	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
91891006361	Ligand Binding Site [chemical binding]; other site
91891006362	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
91891006363	AAA domain; Region: AAA_18; pfam13238
91891006364	active site
91891006365	outer membrane protease; Reviewed; Region: PRK10993
91891006366	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
91891006367	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
91891006368	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
91891006369	dimer interface [polypeptide binding]; other site
91891006370	active site
91891006371	heme binding site [chemical binding]; other site
91891006372	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
91891006373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006374	metabolite-proton symporter; Region: 2A0106; TIGR00883
91891006375	putative substrate translocation pore; other site
91891006376	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
91891006377	Substrate binding site [chemical binding]; other site
91891006378	Ferritin-like domain; Region: Ferritin; pfam00210
91891006379	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
91891006380	dinuclear metal binding motif [ion binding]; other site
91891006381	Methyltransferase domain; Region: Methyltransf_31; pfam13847
91891006382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006383	S-adenosylmethionine binding site [chemical binding]; other site
91891006384	Peptidase family M23; Region: Peptidase_M23; pfam01551
91891006385	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
91891006386	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
91891006387	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
91891006388	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
91891006389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
91891006390	Evidence 4 : Homologs of previously reported genes of unknown function
91891006391	Evidence 4 : Homologs of previously reported genes of unknown function
91891006392	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
91891006393	Beta-lactamase; Region: Beta-lactamase; pfam00144
91891006394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891006395	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891006396	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
91891006397	putative substrate binding pocket [chemical binding]; other site
91891006398	putative dimerization interface [polypeptide binding]; other site
91891006399	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
91891006400	Cytochrome P450; Region: p450; cl12078
91891006401	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
91891006402	nudix motif; other site
91891006403	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
91891006404	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
91891006405	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
91891006406	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
91891006407	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
91891006408	GAF domain; Region: GAF_3; pfam13492
91891006409	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891006410	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891006411	metal binding site [ion binding]; metal-binding site
91891006412	active site
91891006413	I-site; other site
91891006414	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
91891006415	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
91891006416	active site
91891006417	nucleophile elbow; other site
91891006418	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
91891006419	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
91891006420	Ras GTPase Activating Domain; Region: RasGAP; cl02569
91891006421	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
91891006422	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
91891006423	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
91891006424	Beta-lactamase; Region: Beta-lactamase; pfam00144
91891006425	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
91891006426	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
91891006427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891006428	Coenzyme A binding pocket [chemical binding]; other site
91891006429	Winged helix-turn helix; Region: HTH_29; pfam13551
91891006430	Helix-turn-helix domain; Region: HTH_28; pfam13518
91891006431	Integrase core domain; Region: rve; pfam00665
91891006432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
91891006433	Integrase core domain; Region: rve_3; pfam13683
91891006434	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
91891006435	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
91891006436	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
91891006437	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891006438	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
91891006439	Transcriptional regulator [Transcription]; Region: LysR; COG0583
91891006440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
91891006441	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
91891006442	dimerization interface [polypeptide binding]; other site
91891006443	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
91891006444	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
91891006445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891006446	homodimer interface [polypeptide binding]; other site
91891006447	catalytic residue [active]
91891006448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006449	metabolite-proton symporter; Region: 2A0106; TIGR00883
91891006450	putative substrate translocation pore; other site
91891006451	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
91891006452	Coenzyme A transferase; Region: CoA_trans; cl17247
91891006453	malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130
91891006454	malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133
91891006455	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
91891006456	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
91891006457	malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135
91891006458	triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132
91891006459	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
91891006460	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
91891006461	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
91891006462	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
91891006463	active site
91891006464	metal binding site [ion binding]; metal-binding site
91891006465	Cupin domain; Region: Cupin_2; cl17218
91891006466	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
91891006467	Evidence 7 : Gene remnant
91891006468	Evidence 7 : Gene remnant
91891006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006470	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
91891006471	putative substrate translocation pore; other site
91891006472	Predicted flavoprotein [General function prediction only]; Region: COG0431
91891006473	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
91891006474	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
91891006475	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
91891006476	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
91891006477	putative dimer interface [polypeptide binding]; other site
91891006478	N-terminal domain interface [polypeptide binding]; other site
91891006479	putative substrate binding pocket (H-site) [chemical binding]; other site
91891006480	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
91891006481	dimer interface [polypeptide binding]; other site
91891006482	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
91891006483	dimer interface [polypeptide binding]; other site
91891006484	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
91891006485	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
91891006486	N-acetyltransferase; Region: Acetyltransf_2; cl00949
91891006487	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
91891006488	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
91891006489	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
91891006490	Coenzyme A binding pocket [chemical binding]; other site
91891006491	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
91891006492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891006493	active site
91891006494	phosphorylation site [posttranslational modification]
91891006495	intermolecular recognition site; other site
91891006496	dimerization interface [polypeptide binding]; other site
91891006497	PAS domain S-box; Region: sensory_box; TIGR00229
91891006498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891006499	putative active site [active]
91891006500	heme pocket [chemical binding]; other site
91891006501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891006502	dimer interface [polypeptide binding]; other site
91891006503	phosphorylation site [posttranslational modification]
91891006504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891006505	ATP binding site [chemical binding]; other site
91891006506	Mg2+ binding site [ion binding]; other site
91891006507	G-X-G motif; other site
91891006508	Heme NO binding; Region: HNOB; pfam07700
91891006509	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
91891006510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006511	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
91891006512	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
91891006513	nickel binding site [ion binding]; other site
91891006514	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
91891006515	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
91891006516	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
91891006517	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
91891006518	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
91891006519	FAD binding pocket [chemical binding]; other site
91891006520	FAD binding motif [chemical binding]; other site
91891006521	phosphate binding motif [ion binding]; other site
91891006522	beta-alpha-beta structure motif; other site
91891006523	NAD binding pocket [chemical binding]; other site
91891006524	Iron coordination center [ion binding]; other site
91891006525	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
91891006526	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
91891006527	dimerization interface [polypeptide binding]; other site
91891006528	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
91891006529	ATP binding site [chemical binding]; other site
91891006530	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
91891006531	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
91891006532	HupF/HypC family; Region: HupF_HypC; pfam01455
91891006533	Acylphosphatase; Region: Acylphosphatase; pfam00708
91891006534	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
91891006535	HypF finger; Region: zf-HYPF; pfam07503
91891006536	HypF finger; Region: zf-HYPF; pfam07503
91891006537	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
91891006538	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
91891006539	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
91891006540	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
91891006541	High-affinity nickel-transport protein; Region: NicO; cl00964
91891006542	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
91891006543	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
91891006544	Ligand binding site; other site
91891006545	Putative Catalytic site; other site
91891006546	DXD motif; other site
91891006547	GtrA-like protein; Region: GtrA; pfam04138
91891006548	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
91891006549	putative active site [active]
91891006550	YdjC motif; other site
91891006551	Mg binding site [ion binding]; other site
91891006552	putative homodimer interface [polypeptide binding]; other site
91891006553	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
91891006554	EamA-like transporter family; Region: EamA; pfam00892
91891006555	EamA-like transporter family; Region: EamA; pfam00892
91891006556	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891006557	Uncharacterized conserved protein [Function unknown]; Region: COG2128
91891006558	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
91891006559	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
91891006560	active site
91891006561	dimerization interface [polypeptide binding]; other site
91891006562	TPR repeat; Region: TPR_11; pfam13414
91891006563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891006564	binding surface
91891006565	TPR motif; other site
91891006566	TPR repeat; Region: TPR_11; pfam13414
91891006567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891006568	binding surface
91891006569	TPR repeat; Region: TPR_11; pfam13414
91891006570	TPR motif; other site
91891006571	TPR repeat; Region: TPR_11; pfam13414
91891006572	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891006573	binding surface
91891006574	TPR repeat; Region: TPR_11; pfam13414
91891006575	TPR motif; other site
91891006576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891006577	binding surface
91891006578	TPR motif; other site
91891006579	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
91891006580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
91891006581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006582	S-adenosylmethionine binding site [chemical binding]; other site
91891006583	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
91891006584	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
91891006585	active site
91891006586	substrate binding site [chemical binding]; other site
91891006587	metal binding site [ion binding]; metal-binding site
91891006588	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
91891006589	trimer interface [polypeptide binding]; other site
91891006590	active site
91891006591	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
91891006592	Flavoprotein; Region: Flavoprotein; pfam02441
91891006593	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
91891006594	hypothetical protein; Reviewed; Region: PRK00024
91891006595	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
91891006596	MPN+ (JAMM) motif; other site
91891006597	Zinc-binding site [ion binding]; other site
91891006598	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
91891006599	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
91891006600	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
91891006601	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
91891006602	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
91891006603	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
91891006604	putative NAD(P) binding site [chemical binding]; other site
91891006605	putative substrate binding site [chemical binding]; other site
91891006606	catalytic Zn binding site [ion binding]; other site
91891006607	structural Zn binding site [ion binding]; other site
91891006608	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
91891006609	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
91891006610	putative dimer interface [polypeptide binding]; other site
91891006611	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
91891006612	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
91891006613	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
91891006614	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
91891006615	Thiamine pyrophosphokinase; Region: TPK; cd07995
91891006616	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
91891006617	active site
91891006618	dimerization interface [polypeptide binding]; other site
91891006619	thiamine binding site [chemical binding]; other site
91891006620	PQ loop repeat; Region: PQ-loop; pfam04193
91891006621	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
91891006622	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
91891006623	active site clefts [active]
91891006624	zinc binding site [ion binding]; other site
91891006625	dimer interface [polypeptide binding]; other site
91891006626	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891006627	GIY-YIG motif/motif A; other site
91891006628	putative active site [active]
91891006629	putative metal binding site [ion binding]; other site
91891006630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006631	Major Facilitator Superfamily; Region: MFS_1; pfam07690
91891006632	putative substrate translocation pore; other site
91891006633	acyltransferase PapA5; Provisional; Region: PRK09294
91891006634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
91891006635	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
91891006636	dimer interface [polypeptide binding]; other site
91891006637	phosphorylation site [posttranslational modification]
91891006638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891006639	ATP binding site [chemical binding]; other site
91891006640	Mg2+ binding site [ion binding]; other site
91891006641	G-X-G motif; other site
91891006642	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891006643	GIY-YIG motif/motif A; other site
91891006644	putative active site [active]
91891006645	putative metal binding site [ion binding]; other site
91891006646	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891006647	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
91891006648	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891006649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891006650	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891006651	Dot/Icm substrate protein; Region: SidE; pfam12252
91891006652	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
91891006653	Protein export membrane protein; Region: SecD_SecF; cl14618
91891006654	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
91891006655	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891006656	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
91891006657	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
91891006658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006659	D-galactonate transporter; Region: 2A0114; TIGR00893
91891006660	putative substrate translocation pore; other site
91891006661	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
91891006662	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
91891006663	putative DNA binding site [nucleotide binding]; other site
91891006664	putative Zn2+ binding site [ion binding]; other site
91891006665	AsnC family; Region: AsnC_trans_reg; pfam01037
91891006666	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
91891006667	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
91891006668	dimer interface [polypeptide binding]; other site
91891006669	active site
91891006670	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
91891006671	substrate binding site [chemical binding]; other site
91891006672	catalytic residue [active]
91891006673	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
91891006674	active site
91891006675	conformational flexibility of ligand binding pocket; other site
91891006676	ADP-ribosylating toxin turn-turn motif; other site
91891006677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
91891006678	DNA binding residues [nucleotide binding]
91891006679	dimerization interface [polypeptide binding]; other site
91891006680	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891006681	GIY-YIG motif/motif A; other site
91891006682	putative active site [active]
91891006683	putative metal binding site [ion binding]; other site
91891006684	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
91891006685	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
91891006686	active site
91891006687	catalytic site [active]
91891006688	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
91891006689	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
91891006690	Prephenate dehydratase; Region: PDT; pfam00800
91891006691	Chorismate mutase type II; Region: CM_2; smart00830
91891006692	aspartate aminotransferase; Provisional; Region: PRK05764
91891006693	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
91891006694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891006695	homodimer interface [polypeptide binding]; other site
91891006696	catalytic residue [active]
91891006697	tellurite resistance protein TehB; Provisional; Region: PRK12335
91891006698	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
91891006699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006700	S-adenosylmethionine binding site [chemical binding]; other site
91891006701	Transcriptional regulator; Region: Rrf2; cl17282
91891006702	Rrf2 family protein; Region: rrf2_super; TIGR00738
91891006703	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
91891006704	apolar tunnel; other site
91891006705	heme binding site [chemical binding]; other site
91891006706	dimerization interface [polypeptide binding]; other site
91891006707	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
91891006708	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
91891006709	catalytic loop [active]
91891006710	iron binding site [ion binding]; other site
91891006711	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194
91891006712	FAD binding pocket [chemical binding]; other site
91891006713	FAD binding motif [chemical binding]; other site
91891006714	phosphate binding motif [ion binding]; other site
91891006715	beta-alpha-beta structure motif; other site
91891006716	NAD binding pocket [chemical binding]; other site
91891006717	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
91891006718	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
91891006719	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
91891006720	MltA specific insert domain; Region: MltA; smart00925
91891006721	3D domain; Region: 3D; pfam06725
91891006722	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
91891006723	dimer interface [polypeptide binding]; other site
91891006724	putative tRNA-binding site [nucleotide binding]; other site
91891006725	EamA-like transporter family; Region: EamA; pfam00892
91891006726	EamA-like transporter family; Region: EamA; pfam00892
91891006727	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
91891006728	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
91891006729	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
91891006730	putative active site pocket [active]
91891006731	dimerization interface [polypeptide binding]; other site
91891006732	putative catalytic residue [active]
91891006733	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
91891006734	EamA-like transporter family; Region: EamA; pfam00892
91891006735	EamA-like transporter family; Region: EamA; pfam00892
91891006736	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
91891006737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006738	putative substrate translocation pore; other site
91891006739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006740	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
91891006741	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
91891006742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
91891006743	active site
91891006744	motif I; other site
91891006745	motif II; other site
91891006746	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
91891006747	Catalytic domain of Protein Kinases; Region: PKc; cd00180
91891006748	active site
91891006749	ATP binding site [chemical binding]; other site
91891006750	substrate binding site [chemical binding]; other site
91891006751	activation loop (A-loop); other site
91891006752	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
91891006753	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
91891006754	DNA binding residues [nucleotide binding]
91891006755	dimerization interface [polypeptide binding]; other site
91891006756	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
91891006757	active site
91891006758	Int/Topo IB signature motif; other site
91891006759	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
91891006760	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891006761	non-specific DNA binding site [nucleotide binding]; other site
91891006762	salt bridge; other site
91891006763	sequence-specific DNA binding site [nucleotide binding]; other site
91891006764	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
91891006765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891006766	non-specific DNA binding site [nucleotide binding]; other site
91891006767	salt bridge; other site
91891006768	sequence-specific DNA binding site [nucleotide binding]; other site
91891006769	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
91891006770	active site
91891006771	catalytic residues [active]
91891006772	metal binding site [ion binding]; metal-binding site
91891006773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891006774	metabolite-proton symporter; Region: 2A0106; TIGR00883
91891006775	putative substrate translocation pore; other site
91891006776	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
91891006777	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
91891006778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891006779	non-specific DNA binding site [nucleotide binding]; other site
91891006780	salt bridge; other site
91891006781	sequence-specific DNA binding site [nucleotide binding]; other site
91891006782	Global regulator protein family; Region: CsrA; pfam02599
91891006783	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
91891006784	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
91891006785	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
91891006786	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
91891006787	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
91891006788	Protein of unknown function (DUF2895); Region: DUF2895; cl12968
91891006789	integrating conjugative element protein, PFL_4704 family; Region: conj_TIGR03749
91891006790	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
91891006791	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
91891006792	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
91891006793	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
91891006794	Domain of unknown function DUF87; Region: DUF87; pfam01935
91891006795	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
91891006796	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
91891006797	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
91891006798	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
91891006799	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
91891006800	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
91891006801	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
91891006802	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891006803	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
91891006804	Soluble P-type ATPase [General function prediction only]; Region: COG4087
91891006805	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
91891006806	Outer membrane efflux protein; Region: OEP; pfam02321
91891006807	Outer membrane efflux protein; Region: OEP; pfam02321
91891006808	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
91891006809	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891006810	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
91891006811	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
91891006812	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
91891006813	Beta-Casp domain; Region: Beta-Casp; smart01027
91891006814	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
91891006815	thymidine phosphorylase; Provisional; Region: PRK04350
91891006816	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
91891006817	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
91891006818	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
91891006819	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
91891006820	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
91891006821	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
91891006822	active site
91891006823	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
91891006824	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891006825	Soluble P-type ATPase [General function prediction only]; Region: COG4087
91891006826	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
91891006827	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
91891006828	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
91891006829	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891006830	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
91891006831	Domain of unknown function DUF302; Region: DUF302; pfam03625
91891006832	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
91891006833	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
91891006834	metal-binding site [ion binding]
91891006835	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891006836	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
91891006837	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
91891006838	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
91891006839	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
91891006840	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
91891006841	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
91891006842	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
91891006843	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
91891006844	dimer interaction site [polypeptide binding]; other site
91891006845	substrate-binding tunnel; other site
91891006846	active site
91891006847	catalytic site [active]
91891006848	substrate binding site [chemical binding]; other site
91891006849	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
91891006850	Acetokinase family; Region: Acetate_kinase; cl17229
91891006851	propionate/acetate kinase; Provisional; Region: PRK12379
91891006852	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
91891006853	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
91891006854	NAD binding site [chemical binding]; other site
91891006855	homotetramer interface [polypeptide binding]; other site
91891006856	homodimer interface [polypeptide binding]; other site
91891006857	substrate binding site [chemical binding]; other site
91891006858	active site
91891006859	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
91891006860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891006861	NAD(P) binding site [chemical binding]; other site
91891006862	active site
91891006863	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
91891006864	DNA-binding site [nucleotide binding]; DNA binding site
91891006865	RNA-binding motif; other site
91891006866	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
91891006867	Integrase; Region: Integrase_1; pfam12835
91891006868	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
91891006869	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
91891006870	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
91891006871	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
91891006872	dimer interface [polypeptide binding]; other site
91891006873	ssDNA binding site [nucleotide binding]; other site
91891006874	tetramer (dimer of dimers) interface [polypeptide binding]; other site
91891006875	Antirestriction protein (ArdA); Region: ArdA; pfam07275
91891006876	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
91891006877	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
91891006878	Uncharacterized conserved protein [Function unknown]; Region: COG3189
91891006879	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
91891006880	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
91891006881	active site
91891006882	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
91891006883	tetramer interface [polypeptide binding]; other site
91891006884	TPP-binding site [chemical binding]; other site
91891006885	heterodimer interface [polypeptide binding]; other site
91891006886	phosphorylation loop region [posttranslational modification]
91891006887	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
91891006888	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
91891006889	PYR/PP interface [polypeptide binding]; other site
91891006890	dimer interface [polypeptide binding]; other site
91891006891	TPP binding site [chemical binding]; other site
91891006892	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
91891006893	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
91891006894	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
91891006895	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
91891006896	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
91891006897	active site
91891006898	Transposase; Region: DEDD_Tnp_IS110; pfam01548
91891006899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
91891006900	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
91891006901	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891006902	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891006903	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
91891006904	active site
91891006905	catalytic triad [active]
91891006906	oxyanion hole [active]
91891006907	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
91891006908	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
91891006909	active site
91891006910	metal binding site [ion binding]; metal-binding site
91891006911	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
91891006912	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
91891006913	ParB-like nuclease domain; Region: ParBc; pfam02195
91891006914	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
91891006915	16S rRNA methyltransferase B; Provisional; Region: PRK10901
91891006916	NusB family; Region: NusB; pfam01029
91891006917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891006918	S-adenosylmethionine binding site [chemical binding]; other site
91891006919	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
91891006920	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
91891006921	putative active site [active]
91891006922	substrate binding site [chemical binding]; other site
91891006923	putative cosubstrate binding site; other site
91891006924	catalytic site [active]
91891006925	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
91891006926	substrate binding site [chemical binding]; other site
91891006927	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
91891006928	active site
91891006929	catalytic residues [active]
91891006930	metal binding site [ion binding]; metal-binding site
91891006931	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891006932	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
91891006933	DNA protecting protein DprA; Region: dprA; TIGR00732
91891006934	Protein of unknown function (DUF494); Region: DUF494; pfam04361
91891006935	DNA topoisomerase I; Validated; Region: PRK06599
91891006936	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
91891006937	active site
91891006938	interdomain interaction site; other site
91891006939	putative metal-binding site [ion binding]; other site
91891006940	nucleotide binding site [chemical binding]; other site
91891006941	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
91891006942	domain I; other site
91891006943	DNA binding groove [nucleotide binding]
91891006944	phosphate binding site [ion binding]; other site
91891006945	domain II; other site
91891006946	domain III; other site
91891006947	nucleotide binding site [chemical binding]; other site
91891006948	catalytic site [active]
91891006949	domain IV; other site
91891006950	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
91891006951	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
91891006952	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
91891006953	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
91891006954	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
91891006955	Bacterial PH domain; Region: DUF304; pfam03703
91891006956	Protein of unknown function (DUF721); Region: DUF721; pfam05258
91891006957	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
91891006958	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
91891006959	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
91891006960	Uncharacterized conserved protein [Function unknown]; Region: COG4278
91891006961	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
91891006962	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
91891006963	putative active site [active]
91891006964	putative dimer interface [polypeptide binding]; other site
91891006965	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
91891006966	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
91891006967	active site
91891006968	Zn binding site [ion binding]; other site
91891006969	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
91891006970	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
91891006971	cell division protein FtsZ; Validated; Region: PRK09330
91891006972	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
91891006973	nucleotide binding site [chemical binding]; other site
91891006974	SulA interaction site; other site
91891006975	cell division protein FtsA; Region: ftsA; TIGR01174
91891006976	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
91891006977	nucleotide binding site [chemical binding]; other site
91891006978	Cell division protein FtsA; Region: FtsA; pfam14450
91891006979	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
91891006980	Cell division protein FtsQ; Region: FtsQ; pfam03799
91891006981	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
91891006982	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
91891006983	ATP-grasp domain; Region: ATP-grasp_4; cl17255
91891006984	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
91891006985	FAD binding domain; Region: FAD_binding_4; pfam01565
91891006986	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
91891006987	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
91891006988	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
91891006989	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
91891006990	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
91891006991	cell division protein FtsW; Region: ftsW; TIGR02614
91891006992	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
91891006993	TrkA-N domain; Region: TrkA_N; pfam02254
91891006994	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
91891006995	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
91891006996	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
91891006997	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
91891006998	Mg++ binding site [ion binding]; other site
91891006999	putative catalytic motif [active]
91891007000	putative substrate binding site [chemical binding]; other site
91891007001	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
91891007002	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
91891007003	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
91891007004	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
91891007005	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
91891007006	FtsZ protein binding site [polypeptide binding]; other site
91891007007	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
91891007008	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
91891007009	Walker A/P-loop; other site
91891007010	ATP binding site [chemical binding]; other site
91891007011	Q-loop/lid; other site
91891007012	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
91891007013	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
91891007014	Q-loop/lid; other site
91891007015	ABC transporter signature motif; other site
91891007016	Walker B; other site
91891007017	D-loop; other site
91891007018	H-loop/switch region; other site
91891007019	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767
91891007020	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
91891007021	active site
91891007022	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
91891007023	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
91891007024	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
91891007025	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
91891007026	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
91891007027	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
91891007028	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
91891007029	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
91891007030	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
91891007031	ATP-grasp domain; Region: ATP-grasp_4; cl17255
91891007032	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
91891007033	IMP binding site; other site
91891007034	dimer interface [polypeptide binding]; other site
91891007035	interdomain contacts; other site
91891007036	partial ornithine binding site; other site
91891007037	Predicted flavoproteins [General function prediction only]; Region: COG2081
91891007038	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
91891007039	Uncharacterized conserved protein [Function unknown]; Region: COG1434
91891007040	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
91891007041	putative active site [active]
91891007042	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
91891007043	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
91891007044	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
91891007045	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
91891007046	multifunctional aminopeptidase A; Provisional; Region: PRK00913
91891007047	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
91891007048	interface (dimer of trimers) [polypeptide binding]; other site
91891007049	Substrate-binding/catalytic site; other site
91891007050	Zn-binding sites [ion binding]; other site
91891007051	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
91891007052	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
91891007053	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
91891007054	interface (dimer of trimers) [polypeptide binding]; other site
91891007055	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
91891007056	Substrate-binding/catalytic site; other site
91891007057	Zn-binding sites [ion binding]; other site
91891007058	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
91891007059	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
91891007060	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
91891007061	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891007062	Sel1-like repeats; Region: SEL1; smart00671
91891007063	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891007064	Sel1-like repeats; Region: SEL1; smart00671
91891007065	Sel1-like repeats; Region: SEL1; smart00671
91891007066	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891007067	Sel1-like repeats; Region: SEL1; smart00671
91891007068	Sel1-like repeats; Region: SEL1; smart00671
91891007069	Sel1-like repeats; Region: SEL1; smart00671
91891007070	Sel1-like repeats; Region: SEL1; smart00671
91891007071	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
91891007072	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
91891007073	putative active site [active]
91891007074	GAF domain; Region: GAF; pfam01590
91891007075	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891007076	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891007077	metal binding site [ion binding]; metal-binding site
91891007078	active site
91891007079	I-site; other site
91891007080	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
91891007081	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
91891007082	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
91891007083	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
91891007084	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
91891007085	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
91891007086	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
91891007087	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
91891007088	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
91891007089	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
91891007090	GIY-YIG motif/motif A; other site
91891007091	active site
91891007092	catalytic site [active]
91891007093	putative DNA binding site [nucleotide binding]; other site
91891007094	metal binding site [ion binding]; metal-binding site
91891007095	UvrB/uvrC motif; Region: UVR; pfam02151
91891007096	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
91891007097	response regulator; Provisional; Region: PRK09483
91891007098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891007099	active site
91891007100	phosphorylation site [posttranslational modification]
91891007101	intermolecular recognition site; other site
91891007102	dimerization interface [polypeptide binding]; other site
91891007103	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
91891007104	DNA binding residues [nucleotide binding]
91891007105	dimerization interface [polypeptide binding]; other site
91891007106	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
91891007107	cofactor binding site; other site
91891007108	metal binding site [ion binding]; metal-binding site
91891007109	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
91891007110	competence damage-inducible protein A; Provisional; Region: PRK01215
91891007111	putative MPT binding site; other site
91891007112	GTPase CgtA; Reviewed; Region: obgE; PRK12299
91891007113	GTP1/OBG; Region: GTP1_OBG; pfam01018
91891007114	Obg GTPase; Region: Obg; cd01898
91891007115	G1 box; other site
91891007116	GTP/Mg2+ binding site [chemical binding]; other site
91891007117	Switch I region; other site
91891007118	G2 box; other site
91891007119	G3 box; other site
91891007120	Switch II region; other site
91891007121	G4 box; other site
91891007122	G5 box; other site
91891007123	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
91891007124	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
91891007125	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
91891007126	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
91891007127	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
91891007128	5S rRNA interface [nucleotide binding]; other site
91891007129	CTC domain interface [polypeptide binding]; other site
91891007130	L16 interface [polypeptide binding]; other site
91891007131	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
91891007132	putative active site [active]
91891007133	catalytic residue [active]
91891007134	GTP-binding protein YchF; Reviewed; Region: PRK09601
91891007135	YchF GTPase; Region: YchF; cd01900
91891007136	G1 box; other site
91891007137	GTP/Mg2+ binding site [chemical binding]; other site
91891007138	Switch I region; other site
91891007139	G2 box; other site
91891007140	Switch II region; other site
91891007141	G3 box; other site
91891007142	G4 box; other site
91891007143	G5 box; other site
91891007144	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
91891007145	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891007146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891007147	metal binding site [ion binding]; metal-binding site
91891007148	active site
91891007149	I-site; other site
91891007150	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
91891007151	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
91891007152	substrate binding pocket [chemical binding]; other site
91891007153	chain length determination region; other site
91891007154	substrate-Mg2+ binding site; other site
91891007155	catalytic residues [active]
91891007156	aspartate-rich region 1; other site
91891007157	active site lid residues [active]
91891007158	aspartate-rich region 2; other site
91891007159	FeoC like transcriptional regulator; Region: FeoC; pfam09012
91891007160	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
91891007161	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
91891007162	G1 box; other site
91891007163	GTP/Mg2+ binding site [chemical binding]; other site
91891007164	Switch I region; other site
91891007165	G2 box; other site
91891007166	G3 box; other site
91891007167	Switch II region; other site
91891007168	G4 box; other site
91891007169	G5 box; other site
91891007170	Nucleoside recognition; Region: Gate; pfam07670
91891007171	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
91891007172	Nucleoside recognition; Region: Gate; pfam07670
91891007173	FeoA domain; Region: FeoA; pfam04023
91891007174	Predicted ATPase [General function prediction only]; Region: COG1485
91891007175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
91891007176	Walker A motif; other site
91891007177	ATP binding site [chemical binding]; other site
91891007178	Walker B motif; other site
91891007179	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
91891007180	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
91891007181	oligomerization interface [polypeptide binding]; other site
91891007182	active site
91891007183	metal binding site [ion binding]; metal-binding site
91891007184	pantoate--beta-alanine ligase; Region: panC; TIGR00018
91891007185	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
91891007186	active site
91891007187	nucleotide binding site [chemical binding]; other site
91891007188	HIGH motif; other site
91891007189	KMSKS motif; other site
91891007190	AAA domain; Region: AAA_28; pfam13521
91891007191	Predicted ATPase [General function prediction only]; Region: COG3911
91891007192	pyruvate carboxylase subunit A; Validated; Region: PRK07178
91891007193	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
91891007194	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
91891007195	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
91891007196	Dienelactone hydrolase family; Region: DLH; pfam01738
91891007197	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
91891007198	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891007199	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
91891007200	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
91891007201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
91891007202	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
91891007203	DNA binding residues [nucleotide binding]
91891007204	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
91891007205	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
91891007206	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
91891007207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891007208	Walker A/P-loop; other site
91891007209	ATP binding site [chemical binding]; other site
91891007210	Q-loop/lid; other site
91891007211	ABC transporter signature motif; other site
91891007212	Walker B; other site
91891007213	D-loop; other site
91891007214	H-loop/switch region; other site
91891007215	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
91891007216	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
91891007217	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
91891007218	P loop; other site
91891007219	GTP binding site [chemical binding]; other site
91891007220	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
91891007221	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
91891007222	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
91891007223	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
91891007224	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
91891007225	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
91891007226	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
91891007227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007228	S-adenosylmethionine binding site [chemical binding]; other site
91891007229	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
91891007230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
91891007231	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
91891007232	Walker A motif; other site
91891007233	Walker A/P-loop; other site
91891007234	ATP binding site [chemical binding]; other site
91891007235	ATP binding site [chemical binding]; other site
91891007236	Walker B motif; other site
91891007237	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
91891007238	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
91891007239	putative active site [active]
91891007240	putative metal binding site [ion binding]; other site
91891007241	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
91891007242	Methyltransferase domain; Region: Methyltransf_23; pfam13489
91891007243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007244	S-adenosylmethionine binding site [chemical binding]; other site
91891007245	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
91891007246	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
91891007247	NAD binding site [chemical binding]; other site
91891007248	ATP-grasp domain; Region: ATP-grasp_4; cl17255
91891007249	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
91891007250	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
91891007251	active site
91891007252	substrate binding site [chemical binding]; other site
91891007253	FMN binding site [chemical binding]; other site
91891007254	putative catalytic residues [active]
91891007255	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
91891007256	active site
91891007257	catalytic residues [active]
91891007258	metal binding site [ion binding]; metal-binding site
91891007259	tartrate dehydrogenase; Provisional; Region: PRK08194
91891007260	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
91891007261	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
91891007262	Dienelactone hydrolase family; Region: DLH; pfam01738
91891007263	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
91891007264	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
91891007265	Phagosome trafficking protein DotA; Region: DotA; pfam11388
91891007266	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
91891007267	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
91891007268	putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539
91891007269	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
91891007270	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
91891007271	metal-binding site [ion binding]
91891007272	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
91891007273	Methyltransferase domain; Region: Methyltransf_31; pfam13847
91891007274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007275	S-adenosylmethionine binding site [chemical binding]; other site
91891007276	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
91891007277	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
91891007278	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
91891007279	putative active site [active]
91891007280	Zinc-finger domain; Region: zf-CHCC; cl01821
91891007281	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
91891007282	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
91891007283	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
91891007284	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891007285	ATP binding site [chemical binding]; other site
91891007286	Mg2+ binding site [ion binding]; other site
91891007287	G-X-G motif; other site
91891007288	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
91891007289	ATP binding site [chemical binding]; other site
91891007290	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
91891007291	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
91891007292	AMIN domain; Region: AMIN; pfam11741
91891007293	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
91891007294	active site
91891007295	metal binding site [ion binding]; metal-binding site
91891007296	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
91891007297	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
91891007298	putative carbohydrate kinase; Provisional; Region: PRK10565
91891007299	Uncharacterized conserved protein [Function unknown]; Region: COG0062
91891007300	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
91891007301	putative substrate binding site [chemical binding]; other site
91891007302	putative ATP binding site [chemical binding]; other site
91891007303	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
91891007304	stringent starvation protein A; Provisional; Region: sspA; PRK09481
91891007305	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
91891007306	C-terminal domain interface [polypeptide binding]; other site
91891007307	putative GSH binding site (G-site) [chemical binding]; other site
91891007308	dimer interface [polypeptide binding]; other site
91891007309	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
91891007310	dimer interface [polypeptide binding]; other site
91891007311	N-terminal domain interface [polypeptide binding]; other site
91891007312	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
91891007313	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
91891007314	Qi binding site; other site
91891007315	intrachain domain interface; other site
91891007316	interchain domain interface [polypeptide binding]; other site
91891007317	cytochrome b; Validated; Region: CYTB; MTH00016
91891007318	heme bH binding site [chemical binding]; other site
91891007319	heme bL binding site [chemical binding]; other site
91891007320	Qo binding site; other site
91891007321	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
91891007322	interchain domain interface [polypeptide binding]; other site
91891007323	intrachain domain interface; other site
91891007324	Qi binding site; other site
91891007325	Qo binding site; other site
91891007326	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
91891007327	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
91891007328	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
91891007329	[2Fe-2S] cluster binding site [ion binding]; other site
91891007330	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
91891007331	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
91891007332	23S rRNA interface [nucleotide binding]; other site
91891007333	L3 interface [polypeptide binding]; other site
91891007334	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
91891007335	dimer interface [polypeptide binding]; other site
91891007336	[2Fe-2S] cluster binding site [ion binding]; other site
91891007337	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
91891007338	IHF - DNA interface [nucleotide binding]; other site
91891007339	IHF dimer interface [polypeptide binding]; other site
91891007340	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
91891007341	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
91891007342	putative tRNA-binding site [nucleotide binding]; other site
91891007343	B3/4 domain; Region: B3_4; pfam03483
91891007344	tRNA synthetase B5 domain; Region: B5; pfam03484
91891007345	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
91891007346	dimer interface [polypeptide binding]; other site
91891007347	motif 1; other site
91891007348	motif 3; other site
91891007349	motif 2; other site
91891007350	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
91891007351	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
91891007352	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
91891007353	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
91891007354	dimer interface [polypeptide binding]; other site
91891007355	motif 1; other site
91891007356	active site
91891007357	motif 2; other site
91891007358	motif 3; other site
91891007359	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
91891007360	23S rRNA binding site [nucleotide binding]; other site
91891007361	L21 binding site [polypeptide binding]; other site
91891007362	L13 binding site [polypeptide binding]; other site
91891007363	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
91891007364	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
91891007365	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
91891007366	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
91891007367	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
91891007368	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
91891007369	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
91891007370	active site
91891007371	dimer interface [polypeptide binding]; other site
91891007372	motif 1; other site
91891007373	motif 2; other site
91891007374	motif 3; other site
91891007375	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
91891007376	anticodon binding site; other site
91891007377	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
91891007378	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
91891007379	non-specific DNA binding site [nucleotide binding]; other site
91891007380	salt bridge; other site
91891007381	sequence-specific DNA binding site [nucleotide binding]; other site
91891007382	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
91891007383	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
91891007384	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
91891007385	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
91891007386	ligand binding site [chemical binding]; other site
91891007387	flexible hinge region; other site
91891007388	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
91891007389	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
91891007390	ligand binding site [chemical binding]; other site
91891007391	flexible hinge region; other site
91891007392	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
91891007393	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
91891007394	putative active site [active]
91891007395	putative dimer interface [polypeptide binding]; other site
91891007396	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
91891007397	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
91891007398	FMN binding site [chemical binding]; other site
91891007399	active site
91891007400	substrate binding site [chemical binding]; other site
91891007401	catalytic residue [active]
91891007402	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
91891007403	dimerization interface [polypeptide binding]; other site
91891007404	putative DNA binding site [nucleotide binding]; other site
91891007405	putative Zn2+ binding site [ion binding]; other site
91891007406	Predicted membrane protein [Function unknown]; Region: COG2860
91891007407	UPF0126 domain; Region: UPF0126; pfam03458
91891007408	UPF0126 domain; Region: UPF0126; pfam03458
91891007409	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
91891007410	substrate binding site [chemical binding]; other site
91891007411	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
91891007412	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
91891007413	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
91891007414	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
91891007415	hypothetical protein; Provisional; Region: PRK07179
91891007416	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
91891007417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
91891007418	catalytic residue [active]
91891007419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891007420	active site
91891007421	phosphorylation site [posttranslational modification]
91891007422	intermolecular recognition site; other site
91891007423	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
91891007424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
91891007425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
91891007426	ATP binding site [chemical binding]; other site
91891007427	Mg2+ binding site [ion binding]; other site
91891007428	G-X-G motif; other site
91891007429	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
91891007430	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
91891007431	domain interfaces; other site
91891007432	active site
91891007433	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
91891007434	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
91891007435	active site
91891007436	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
91891007437	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
91891007438	HemY protein N-terminus; Region: HemY_N; pfam07219
91891007439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
91891007440	TPR motif; other site
91891007441	binding surface
91891007442	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
91891007443	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
91891007444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
91891007445	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
91891007446	catalytic site [active]
91891007447	putative active site [active]
91891007448	putative substrate binding site [chemical binding]; other site
91891007449	dimer interface [polypeptide binding]; other site
91891007450	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
91891007451	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
91891007452	active site
91891007453	NTP binding site [chemical binding]; other site
91891007454	metal binding triad [ion binding]; metal-binding site
91891007455	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
91891007456	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
91891007457	Zn2+ binding site [ion binding]; other site
91891007458	Mg2+ binding site [ion binding]; other site
91891007459	GTPase RsgA; Reviewed; Region: PRK12288
91891007460	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
91891007461	RNA binding site [nucleotide binding]; other site
91891007462	homodimer interface [polypeptide binding]; other site
91891007463	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
91891007464	GTPase/Zn-binding domain interface [polypeptide binding]; other site
91891007465	GTP/Mg2+ binding site [chemical binding]; other site
91891007466	G4 box; other site
91891007467	G5 box; other site
91891007468	G1 box; other site
91891007469	Switch I region; other site
91891007470	G2 box; other site
91891007471	G3 box; other site
91891007472	Switch II region; other site
91891007473	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891007474	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme
91891007475	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
91891007476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891007477	Walker A motif; other site
91891007478	ATP binding site [chemical binding]; other site
91891007479	Walker B motif; other site
91891007480	arginine finger; other site
91891007481	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
91891007482	hypothetical protein; Validated; Region: PRK00153
91891007483	recombination protein RecR; Reviewed; Region: recR; PRK00076
91891007484	RecR protein; Region: RecR; pfam02132
91891007485	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
91891007486	putative active site [active]
91891007487	putative metal-binding site [ion binding]; other site
91891007488	tetramer interface [polypeptide binding]; other site
91891007489	Protein of unknown function, DUF547; Region: DUF547; pfam04784
91891007490	Sulfatase; Region: Sulfatase; cl17466
91891007491	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
91891007492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
91891007493	active site
91891007494	dimerization interface [polypeptide binding]; other site
91891007495	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
91891007496	DNA binding site [nucleotide binding]
91891007497	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
91891007498	Domain of unknown function DUF21; Region: DUF21; pfam01595
91891007499	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
91891007500	Transporter associated domain; Region: CorC_HlyC; smart01091
91891007501	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
91891007502	dimer interface [polypeptide binding]; other site
91891007503	substrate binding site [chemical binding]; other site
91891007504	metal binding sites [ion binding]; metal-binding site
91891007505	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
91891007506	nucleotide binding site/active site [active]
91891007507	HIT family signature motif; other site
91891007508	catalytic residue [active]
91891007509	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
91891007510	GTP cyclohydrolase I; Provisional; Region: PLN03044
91891007511	homodecamer interface [polypeptide binding]; other site
91891007512	active site
91891007513	putative catalytic site residues [active]
91891007514	zinc binding site [ion binding]; other site
91891007515	GTP-CH-I/GFRP interaction surface; other site
91891007516	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
91891007517	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
91891007518	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
91891007519	RNase E interface [polypeptide binding]; other site
91891007520	trimer interface [polypeptide binding]; other site
91891007521	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
91891007522	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
91891007523	RNase E interface [polypeptide binding]; other site
91891007524	trimer interface [polypeptide binding]; other site
91891007525	active site
91891007526	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
91891007527	putative nucleic acid binding region [nucleotide binding]; other site
91891007528	G-X-X-G motif; other site
91891007529	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
91891007530	RNA binding site [nucleotide binding]; other site
91891007531	domain interface; other site
91891007532	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
91891007533	16S/18S rRNA binding site [nucleotide binding]; other site
91891007534	S13e-L30e interaction site [polypeptide binding]; other site
91891007535	25S rRNA binding site [nucleotide binding]; other site
91891007536	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
91891007537	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
91891007538	RNA binding site [nucleotide binding]; other site
91891007539	active site
91891007540	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
91891007541	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
91891007542	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
91891007543	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
91891007544	translation initiation factor IF-2; Region: IF-2; TIGR00487
91891007545	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
91891007546	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
91891007547	G1 box; other site
91891007548	putative GEF interaction site [polypeptide binding]; other site
91891007549	GTP/Mg2+ binding site [chemical binding]; other site
91891007550	Switch I region; other site
91891007551	G2 box; other site
91891007552	G3 box; other site
91891007553	Switch II region; other site
91891007554	G4 box; other site
91891007555	G5 box; other site
91891007556	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
91891007557	Translation-initiation factor 2; Region: IF-2; pfam11987
91891007558	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
91891007559	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
91891007560	NusA N-terminal domain; Region: NusA_N; pfam08529
91891007561	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
91891007562	RNA binding site [nucleotide binding]; other site
91891007563	homodimer interface [polypeptide binding]; other site
91891007564	NusA-like KH domain; Region: KH_5; pfam13184
91891007565	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
91891007566	G-X-X-G motif; other site
91891007567	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
91891007568	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
91891007569	ribosome maturation protein RimP; Reviewed; Region: PRK00092
91891007570	Sm and related proteins; Region: Sm_like; cl00259
91891007571	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
91891007572	putative oligomer interface [polypeptide binding]; other site
91891007573	putative RNA binding site [nucleotide binding]; other site
91891007574	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
91891007575	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
91891007576	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
91891007577	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
91891007578	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
91891007579	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
91891007580	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
91891007581	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
91891007582	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
91891007583	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
91891007584	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
91891007585	4Fe-4S binding domain; Region: Fer4; cl02805
91891007586	4Fe-4S binding domain; Region: Fer4; pfam00037
91891007587	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
91891007588	NADH dehydrogenase subunit G; Validated; Region: PRK09129
91891007589	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
91891007590	catalytic loop [active]
91891007591	iron binding site [ion binding]; other site
91891007592	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
91891007593	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
91891007594	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
91891007595	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
91891007596	SLBB domain; Region: SLBB; pfam10531
91891007597	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
91891007598	NADH dehydrogenase subunit E; Validated; Region: PRK07539
91891007599	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
91891007600	putative dimer interface [polypeptide binding]; other site
91891007601	[2Fe-2S] cluster binding site [ion binding]; other site
91891007602	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
91891007603	NADH dehydrogenase subunit D; Validated; Region: PRK06075
91891007604	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
91891007605	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
91891007606	NADH dehydrogenase subunit B; Validated; Region: PRK06411
91891007607	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
91891007608	Preprotein translocase SecG subunit; Region: SecG; pfam03840
91891007609	triosephosphate isomerase; Provisional; Region: PRK14567
91891007610	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
91891007611	substrate binding site [chemical binding]; other site
91891007612	dimer interface [polypeptide binding]; other site
91891007613	catalytic triad [active]
91891007614	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
91891007615	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
91891007616	active site
91891007617	substrate binding site [chemical binding]; other site
91891007618	metal binding site [ion binding]; metal-binding site
91891007619	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
91891007620	dihydropteroate synthase; Region: DHPS; TIGR01496
91891007621	substrate binding pocket [chemical binding]; other site
91891007622	dimer interface [polypeptide binding]; other site
91891007623	inhibitor binding site; inhibition site
91891007624	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
91891007625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891007626	Walker A motif; other site
91891007627	ATP binding site [chemical binding]; other site
91891007628	Walker B motif; other site
91891007629	arginine finger; other site
91891007630	Peptidase family M41; Region: Peptidase_M41; pfam01434
91891007631	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
91891007632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007633	S-adenosylmethionine binding site [chemical binding]; other site
91891007634	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
91891007635	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
91891007636	IucA / IucC family; Region: IucA_IucC; pfam04183
91891007637	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
91891007638	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
91891007639	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
91891007640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
91891007641	Walker A motif; other site
91891007642	ATP binding site [chemical binding]; other site
91891007643	Walker B motif; other site
91891007644	arginine finger; other site
91891007645	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
91891007646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891007647	putative substrate translocation pore; other site
91891007648	POT family; Region: PTR2; cl17359
91891007649	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
91891007650	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
91891007651	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
91891007652	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
91891007653	shikimate binding site; other site
91891007654	NAD(P) binding site [chemical binding]; other site
91891007655	aminopeptidase N; Provisional; Region: pepN; PRK14015
91891007656	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
91891007657	active site
91891007658	Zn binding site [ion binding]; other site
91891007659	PrkA family serine protein kinase; Provisional; Region: PRK15455
91891007660	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
91891007661	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
91891007662	hypothetical protein; Provisional; Region: PRK05325
91891007663	SpoVR family protein; Provisional; Region: PRK11767
91891007664	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
91891007665	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
91891007666	Peptidase family M28; Region: Peptidase_M28; pfam04389
91891007667	active site
91891007668	metal binding site [ion binding]; metal-binding site
91891007669	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
91891007670	Part of AAA domain; Region: AAA_19; pfam13245
91891007671	Family description; Region: UvrD_C_2; pfam13538
91891007672	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
91891007673	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
91891007674	dimerization interface [polypeptide binding]; other site
91891007675	domain crossover interface; other site
91891007676	redox-dependent activation switch; other site
91891007677	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
91891007678	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
91891007679	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
91891007680	active site
91891007681	catalytic tetrad [active]
91891007682	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
91891007683	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
91891007684	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
91891007685	G1 box; other site
91891007686	putative GEF interaction site [polypeptide binding]; other site
91891007687	GTP/Mg2+ binding site [chemical binding]; other site
91891007688	Switch I region; other site
91891007689	G2 box; other site
91891007690	G3 box; other site
91891007691	Switch II region; other site
91891007692	G4 box; other site
91891007693	G5 box; other site
91891007694	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
91891007695	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
91891007696	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
91891007697	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
91891007698	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
91891007699	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
91891007700	Walker A/P-loop; other site
91891007701	ATP binding site [chemical binding]; other site
91891007702	Q-loop/lid; other site
91891007703	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
91891007704	ABC transporter signature motif; other site
91891007705	Walker B; other site
91891007706	D-loop; other site
91891007707	H-loop/switch region; other site
91891007708	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
91891007709	DNA-binding site [nucleotide binding]; DNA binding site
91891007710	RNA-binding motif; other site
91891007711	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
91891007712	conserved cys residue [active]
91891007713	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
91891007714	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
91891007715	Amidinotransferase; Region: Amidinotransf; pfam02274
91891007716	U-box domain; Region: U-box; cl17544
91891007717	U-box domain; Region: U-box; cl17544
91891007718	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
91891007719	active site
91891007720	nucleophile elbow; other site
91891007721	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
91891007722	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
91891007723	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
91891007724	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
91891007725	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
91891007726	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
91891007727	RNA binding site [nucleotide binding]; other site
91891007728	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
91891007729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007730	S-adenosylmethionine binding site [chemical binding]; other site
91891007731	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
91891007732	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
91891007733	glutaminase active site [active]
91891007734	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
91891007735	dimer interface [polypeptide binding]; other site
91891007736	active site
91891007737	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
91891007738	dimer interface [polypeptide binding]; other site
91891007739	active site
91891007740	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
91891007741	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
91891007742	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
91891007743	active site
91891007744	oxyanion hole [active]
91891007745	catalytic triad [active]
91891007746	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891007747	GIY-YIG motif/motif A; other site
91891007748	putative active site [active]
91891007749	putative metal binding site [ion binding]; other site
91891007750	rhodanese superfamily protein; Provisional; Region: PRK05320
91891007751	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
91891007752	active site residue [active]
91891007753	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
91891007754	SmpB-tmRNA interface; other site
91891007755	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
91891007756	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
91891007757	catalytic triad [active]
91891007758	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
91891007759	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
91891007760	putative substrate translocation pore; other site
91891007761	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
91891007762	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
91891007763	putative active site [active]
91891007764	PhoH-like protein; Region: PhoH; pfam02562
91891007765	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
91891007766	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
91891007767	active site
91891007768	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
91891007769	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
91891007770	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
91891007771	B1 nucleotide binding pocket [chemical binding]; other site
91891007772	B2 nucleotide binding pocket [chemical binding]; other site
91891007773	CAS motifs; other site
91891007774	active site
91891007775	TPR repeat; Region: TPR_11; pfam13414
91891007776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891007777	TPR motif; other site
91891007778	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
91891007779	Methyltransferase domain; Region: Methyltransf_24; pfam13578
91891007780	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
91891007781	DNA-binding site [nucleotide binding]; DNA binding site
91891007782	RNA-binding motif; other site
91891007783	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
91891007784	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
91891007785	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
91891007786	Amidase; Region: Amidase; cl11426
91891007787	Oxygen tolerance; Region: BatD; pfam13584
91891007788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
91891007789	binding surface
91891007790	TPR motif; other site
91891007791	Tetratricopeptide repeat; Region: TPR_16; pfam13432
91891007792	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
91891007793	metal ion-dependent adhesion site (MIDAS); other site
91891007794	Aerotolerance regulator N-terminal; Region: BatA; cl06567
91891007795	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
91891007796	metal ion-dependent adhesion site (MIDAS); other site
91891007797	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
91891007798	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
91891007799	Protein of unknown function DUF58; Region: DUF58; pfam01882
91891007800	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
91891007801	metal ion-dependent adhesion site (MIDAS); other site
91891007802	MoxR-like ATPases [General function prediction only]; Region: COG0714
91891007803	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
91891007804	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
91891007805	FMN binding site [chemical binding]; other site
91891007806	active site
91891007807	catalytic residues [active]
91891007808	substrate binding site [chemical binding]; other site
91891007809	pteridine reductase; Provisional; Region: PRK09135
91891007810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
91891007811	NAD(P) binding site [chemical binding]; other site
91891007812	active site
91891007813	Uncharacterized conserved protein [Function unknown]; Region: COG1565
91891007814	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
91891007815	primosome assembly protein PriA; Validated; Region: PRK05580
91891007816	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
91891007817	ATP binding site [chemical binding]; other site
91891007818	putative Mg++ binding site [ion binding]; other site
91891007819	nucleotide binding region [chemical binding]; other site
91891007820	helicase superfamily c-terminal domain; Region: HELICc; smart00490
91891007821	ATP-binding site [chemical binding]; other site
91891007822	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
91891007823	active site
91891007824	thymidylate synthase; Reviewed; Region: thyA; PRK01827
91891007825	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
91891007826	dimerization interface [polypeptide binding]; other site
91891007827	active site
91891007828	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
91891007829	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
91891007830	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
91891007831	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
91891007832	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
91891007833	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
91891007834	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
91891007835	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
91891007836	putative active site [active]
91891007837	Ap4A binding site [chemical binding]; other site
91891007838	nudix motif; other site
91891007839	putative metal binding site [ion binding]; other site
91891007840	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
91891007841	active site
91891007842	homodimer interface [polypeptide binding]; other site
91891007843	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
91891007844	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
91891007845	Substrate binding site; other site
91891007846	Mg++ binding site; other site
91891007847	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
91891007848	active site
91891007849	substrate binding site [chemical binding]; other site
91891007850	CoA binding site [chemical binding]; other site
91891007851	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component
91891007852	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
91891007853	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
91891007854	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
91891007855	oligomer interface [polypeptide binding]; other site
91891007856	metal binding site [ion binding]; metal-binding site
91891007857	metal binding site [ion binding]; metal-binding site
91891007858	Cl binding site [ion binding]; other site
91891007859	aspartate ring; other site
91891007860	basic sphincter; other site
91891007861	putative hydrophobic gate; other site
91891007862	periplasmic entrance; other site
91891007863	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
91891007864	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
91891007865	minor groove reading motif; other site
91891007866	helix-hairpin-helix signature motif; other site
91891007867	substrate binding pocket [chemical binding]; other site
91891007868	active site
91891007869	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
91891007870	ferredoxin; Provisional; Region: PRK08764
91891007871	Putative Fe-S cluster; Region: FeS; pfam04060
91891007872	4Fe-4S binding domain; Region: Fer4; pfam00037
91891007873	4Fe-4S binding domain; Region: Fer4; cl02805
91891007874	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
91891007875	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
91891007876	active site
91891007877	HIGH motif; other site
91891007878	KMSKS motif; other site
91891007879	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
91891007880	anticodon binding site; other site
91891007881	tRNA binding surface [nucleotide binding]; other site
91891007882	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
91891007883	dimer interface [polypeptide binding]; other site
91891007884	putative tRNA-binding site [nucleotide binding]; other site
91891007885	polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421
91891007886	Flavoprotein; Region: Flavoprotein; pfam02441
91891007887	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
91891007888	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
91891007889	Ligand Binding Site [chemical binding]; other site
91891007890	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
91891007891	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
91891007892	Substrate binding site; other site
91891007893	Cupin domain; Region: Cupin_2; cl17218
91891007894	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891007895	putative active site [active]
91891007896	GIY-YIG motif/motif A; other site
91891007897	putative metal binding site [ion binding]; other site
91891007898	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
91891007899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
91891007900	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
91891007901	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
91891007902	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
91891007903	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007904	S-adenosylmethionine binding site [chemical binding]; other site
91891007905	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
91891007906	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
91891007907	P-loop; other site
91891007908	Magnesium ion binding site [ion binding]; other site
91891007909	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
91891007910	Magnesium ion binding site [ion binding]; other site
91891007911	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
91891007912	ParB-like nuclease domain; Region: ParBc; pfam02195
91891007913	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
91891007914	Subunit III/VIIa interface [polypeptide binding]; other site
91891007915	Phospholipid binding site [chemical binding]; other site
91891007916	Subunit I/III interface [polypeptide binding]; other site
91891007917	Subunit III/VIb interface [polypeptide binding]; other site
91891007918	Subunit III/VIa interface; other site
91891007919	Subunit III/Vb interface [polypeptide binding]; other site
91891007920	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
91891007921	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
91891007922	Subunit I/III interface [polypeptide binding]; other site
91891007923	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
91891007924	D-pathway; other site
91891007925	Subunit I/VIIc interface [polypeptide binding]; other site
91891007926	Subunit I/IV interface [polypeptide binding]; other site
91891007927	Subunit I/II interface [polypeptide binding]; other site
91891007928	Low-spin heme (heme a) binding site [chemical binding]; other site
91891007929	Subunit I/VIIa interface [polypeptide binding]; other site
91891007930	Subunit I/VIa interface [polypeptide binding]; other site
91891007931	Dimer interface; other site
91891007932	Putative water exit pathway; other site
91891007933	Binuclear center (heme a3/CuB) [ion binding]; other site
91891007934	K-pathway; other site
91891007935	Subunit I/Vb interface [polypeptide binding]; other site
91891007936	Putative proton exit pathway; other site
91891007937	Subunit I/VIb interface; other site
91891007938	Subunit I/VIc interface [polypeptide binding]; other site
91891007939	Electron transfer pathway; other site
91891007940	Subunit I/VIIIb interface [polypeptide binding]; other site
91891007941	Subunit I/VIIb interface [polypeptide binding]; other site
91891007942	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
91891007943	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168
91891007944	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
91891007945	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
91891007946	Cytochrome c; Region: Cytochrom_C; pfam00034
91891007947	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
91891007948	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
91891007949	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
91891007950	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
91891007951	iron-sulfur cluster [ion binding]; other site
91891007952	[2Fe-2S] cluster binding site [ion binding]; other site
91891007953	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
91891007954	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
91891007955	Lysine efflux permease [General function prediction only]; Region: COG1279
91891007956	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
91891007957	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
91891007958	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
91891007959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
91891007960	S-adenosylmethionine binding site [chemical binding]; other site
91891007961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
91891007962	SCP-2 sterol transfer family; Region: SCP2; pfam02036
91891007963	SCP-2 sterol transfer family; Region: SCP2; cl01225
91891007964	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
91891007965	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
91891007966	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
91891007967	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
91891007968	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
91891007969	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
91891007970	methionine sulfoxide reductase A; Provisional; Region: PRK14054
91891007971	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
91891007972	GAF domain; Region: GAF; pfam01590
91891007973	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
91891007974	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
91891007975	metal binding site [ion binding]; metal-binding site
91891007976	active site
91891007977	I-site; other site
91891007978	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
91891007979	tyramine oxidase; Provisional; Region: tynA; PRK11504
91891007980	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
91891007981	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
91891007982	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
91891007983	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
91891007984	Sel1-like repeats; Region: SEL1; smart00671
91891007985	Sel1-like repeats; Region: SEL1; smart00671
91891007986	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
91891007987	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
91891007988	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
91891007989	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
91891007990	Transglycosylase SLT domain; Region: SLT_2; pfam13406
91891007991	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
91891007992	N-acetyl-D-glucosamine binding site [chemical binding]; other site
91891007993	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
91891007994	Beta-lactamase; Region: Beta-lactamase; pfam00144
91891007995	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
91891007996	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
91891007997	active site
91891007998	NTP binding site [chemical binding]; other site
91891007999	metal binding triad [ion binding]; metal-binding site
91891008000	antibiotic binding site [chemical binding]; other site
91891008001	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
91891008002	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
91891008003	FtsX-like permease family; Region: FtsX; pfam02687
91891008004	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
91891008005	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
91891008006	Walker A/P-loop; other site
91891008007	ATP binding site [chemical binding]; other site
91891008008	Q-loop/lid; other site
91891008009	ABC transporter signature motif; other site
91891008010	Walker B; other site
91891008011	D-loop; other site
91891008012	H-loop/switch region; other site
91891008013	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
91891008014	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
91891008015	HlyD family secretion protein; Region: HlyD_3; pfam13437
91891008016	Outer membrane efflux protein; Region: OEP; pfam02321
91891008017	Outer membrane efflux protein; Region: OEP; pfam02321
91891008018	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
91891008019	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
91891008020	active site
91891008021	metal binding site [ion binding]; metal-binding site
91891008022	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
91891008023	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
91891008024	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
91891008025	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
91891008026	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
91891008027	tetramerization interface [polypeptide binding]; other site
91891008028	active site
91891008029	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
91891008030	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
91891008031	FMN reductase; Validated; Region: fre; PRK08051
91891008032	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
91891008033	FAD binding pocket [chemical binding]; other site
91891008034	FAD binding motif [chemical binding]; other site
91891008035	phosphate binding motif [ion binding]; other site
91891008036	beta-alpha-beta structure motif; other site
91891008037	NAD binding pocket [chemical binding]; other site
91891008038	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
91891008039	transcription termination factor Rho; Provisional; Region: rho; PRK09376
91891008040	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
91891008041	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
91891008042	RNA binding site [nucleotide binding]; other site
91891008043	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
91891008044	multimer interface [polypeptide binding]; other site
91891008045	Walker A motif; other site
91891008046	ATP binding site [chemical binding]; other site
91891008047	Walker B motif; other site
91891008048	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
91891008049	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
91891008050	catalytic residues [active]
91891008051	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
91891008052	RNA methyltransferase, RsmE family; Region: TIGR00046
91891008053	fumarate hydratase; Reviewed; Region: fumC; PRK00485
91891008054	Class II fumarases; Region: Fumarase_classII; cd01362
91891008055	active site
91891008056	tetramer interface [polypeptide binding]; other site
91891008057	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
91891008058	BNR repeat-like domain; Region: BNR_2; pfam13088
91891008059	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
91891008060	putative acyl-acceptor binding pocket; other site
91891008061	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
91891008062	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
91891008063	putative acyl-acceptor binding pocket; other site
91891008064	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
91891008065	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
91891008066	active site
91891008067	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
91891008068	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
91891008069	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
91891008070	trimer interface [polypeptide binding]; other site
91891008071	active site
91891008072	UDP-GlcNAc binding site [chemical binding]; other site
91891008073	lipid binding site [chemical binding]; lipid-binding site
91891008074	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
91891008075	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
91891008076	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
91891008077	active site
91891008078	nucleotide-binding site [chemical binding]; other site
91891008079	metal-binding site [ion binding]
91891008080	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
91891008081	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
91891008082	Walker A/P-loop; other site
91891008083	ATP binding site [chemical binding]; other site
91891008084	Q-loop/lid; other site
91891008085	ABC transporter signature motif; other site
91891008086	Walker B; other site
91891008087	D-loop; other site
91891008088	H-loop/switch region; other site
91891008089	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
91891008090	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
91891008091	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
91891008092	active site
91891008093	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
91891008094	Ligand Binding Site [chemical binding]; other site
91891008095	Molecular Tunnel; other site
91891008096	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
91891008097	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
91891008098	dimer interface [polypeptide binding]; other site
91891008099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891008100	catalytic residue [active]
91891008101	Histone methylation protein DOT1; Region: DOT1; pfam08123
91891008102	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
91891008103	IHF dimer interface [polypeptide binding]; other site
91891008104	IHF - DNA interface [nucleotide binding]; other site
91891008105	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
91891008106	trimer interface [polypeptide binding]; other site
91891008107	active site
91891008108	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891008109	GIY-YIG motif/motif A; other site
91891008110	putative active site [active]
91891008111	putative metal binding site [ion binding]; other site
91891008112	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
91891008113	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
91891008114	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
91891008115	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
91891008116	dimer interface [polypeptide binding]; other site
91891008117	active site residues [active]
91891008118	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
91891008119	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
91891008120	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
91891008121	Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150
91891008122	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
91891008123	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
91891008124	ligand binding site [chemical binding]; other site
91891008125	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
91891008126	active site
91891008127	substrate binding pocket [chemical binding]; other site
91891008128	dimer interface [polypeptide binding]; other site
91891008129	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
91891008130	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
91891008131	dimer interface [polypeptide binding]; other site
91891008132	catalytic site [active]
91891008133	putative active site [active]
91891008134	putative substrate binding site [chemical binding]; other site
91891008135	peroxidase; Provisional; Region: PRK15000
91891008136	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
91891008137	dimer interface [polypeptide binding]; other site
91891008138	decamer (pentamer of dimers) interface [polypeptide binding]; other site
91891008139	catalytic triad [active]
91891008140	peroxidatic and resolving cysteines [active]
91891008141	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
91891008142	putative GSH binding site [chemical binding]; other site
91891008143	catalytic residues [active]
91891008144	superoxide dismutase; Provisional; Region: PRK10543
91891008145	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
91891008146	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
91891008147	acetylornithine aminotransferase; Provisional; Region: PRK02627
91891008148	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
91891008149	inhibitor-cofactor binding pocket; inhibition site
91891008150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
91891008151	catalytic residue [active]
91891008152	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
91891008153	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
91891008154	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
91891008155	active site
91891008156	catalytic site [active]
91891008157	malate dehydrogenase; Provisional; Region: PRK13529
91891008158	Malic enzyme, N-terminal domain; Region: malic; pfam00390
91891008159	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
91891008160	NAD(P) binding site [chemical binding]; other site
91891008161	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
91891008162	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
91891008163	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
91891008164	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
91891008165	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
91891008166	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
91891008167	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
91891008168	active site
91891008169	Zn binding site [ion binding]; other site
91891008170	Rossmann-like domain; Region: Rossmann-like; pfam10727
91891008171	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
91891008172	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
91891008173	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
91891008174	CAP-like domain; other site
91891008175	active site
91891008176	primary dimer interface [polypeptide binding]; other site
91891008177	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891008178	putative active site [active]
91891008179	GIY-YIG motif/motif A; other site
91891008180	putative metal binding site [ion binding]; other site
91891008181	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
91891008182	Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin
91891008183	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
91891008184	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
91891008185	gamma subunit interface [polypeptide binding]; other site
91891008186	LBP interface [polypeptide binding]; other site
91891008187	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
91891008188	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
91891008189	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
91891008190	alpha subunit interaction interface [polypeptide binding]; other site
91891008191	Walker A motif; other site
91891008192	ATP binding site [chemical binding]; other site
91891008193	Walker B motif; other site
91891008194	inhibitor binding site; inhibition site
91891008195	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
91891008196	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
91891008197	core domain interface [polypeptide binding]; other site
91891008198	delta subunit interface [polypeptide binding]; other site
91891008199	epsilon subunit interface [polypeptide binding]; other site
91891008200	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
91891008201	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
91891008202	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
91891008203	beta subunit interaction interface [polypeptide binding]; other site
91891008204	Walker A motif; other site
91891008205	ATP binding site [chemical binding]; other site
91891008206	Walker B motif; other site
91891008207	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
91891008208	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
91891008209	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
91891008210	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
91891008211	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
91891008212	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
91891008213	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
91891008214	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
91891008215	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
91891008216	outer membrane lipoprotein; Provisional; Region: PRK11023
91891008217	BON domain; Region: BON; pfam04972
91891008218	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
91891008219	BON domain; Region: BON; pfam04972
91891008220	BON domain; Region: BON; cl02771
91891008221	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
91891008222	dimer interface [polypeptide binding]; other site
91891008223	active site
91891008224	hypothetical protein; Reviewed; Region: PRK12497
91891008225	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
91891008226	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
91891008227	putative ligand binding site [chemical binding]; other site
91891008228	Predicted methyltransferases [General function prediction only]; Region: COG0313
91891008229	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
91891008230	putative SAM binding site [chemical binding]; other site
91891008231	putative homodimer interface [polypeptide binding]; other site
91891008232	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
91891008233	Fatty acid desaturase; Region: FA_desaturase; pfam00487
91891008234	Di-iron ligands [ion binding]; other site
91891008235	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
91891008236	Sulfate transporter family; Region: Sulfate_transp; pfam00916
91891008237	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
91891008238	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
91891008239	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
91891008240	ligand binding site [chemical binding]; other site
91891008241	flexible hinge region; other site
91891008242	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
91891008243	putative active site [active]
91891008244	GIY-YIG motif/motif A; other site
91891008245	putative metal binding site [ion binding]; other site
91891008246	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
91891008247	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
91891008248	active site
91891008249	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
91891008250	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
91891008251	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
91891008252	GTP/Mg2+ binding site [chemical binding]; other site
91891008253	G4 box; other site
91891008254	G5 box; other site
91891008255	trmE is a tRNA modification GTPase; Region: trmE; cd04164
91891008256	G1 box; other site
91891008257	G1 box; other site
91891008258	GTP/Mg2+ binding site [chemical binding]; other site
91891008259	Switch I region; other site
91891008260	Switch I region; other site
91891008261	G2 box; other site
91891008262	G2 box; other site
91891008263	Switch II region; other site
91891008264	G3 box; other site
91891008265	G4 box; other site
91891008266	G5 box; other site
91891008267	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
91891008268	membrane protein insertase; Provisional; Region: PRK01318
91891008269	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
91891008270	Ribonuclease P; Region: Ribonuclease_P; cl00457
91891008271	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1046632008272	AAA domain; Region: AAA_31; pfam13614
1046632008273	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1046632008274	P-loop; other site
1046632008275	Magnesium ion binding site [ion binding]; other site
1046632008276	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1046632008277	Magnesium ion binding site [ion binding]; other site
1046632008278	ParB-like nuclease domain; Region: ParB; smart00470
1046632008279	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1046632008280	Initiator Replication protein; Region: Rep_3; pfam01051
1046632008281	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1046632008282	ParB-like nuclease domain; Region: ParB; smart00470
1046632008283	WGR domain; Region: WGR; cl01581
1046632008284	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1046632008285	active site
1046632008286	catalytic residues [active]
1046632008287	DNA binding site [nucleotide binding]
1046632008288	Int/Topo IB signature motif; other site
1046632008289	RecX family; Region: RecX; pfam02631
1046632008290	topology modulation protein; Reviewed; Region: PRK08118
1046632008291	AAA domain; Region: AAA_17; pfam13207
1046632008292	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1046632008293	active site
1046632008294	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1046632008295	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1046632008296	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1046632008297	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1046632008298	Phosphotransferase enzyme family; Region: APH; pfam01636
1046632008299	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1046632008300	substrate binding site [chemical binding]; other site
1046632008301	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1046632008302	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1046632008303	non-specific DNA binding site [nucleotide binding]; other site
1046632008304	salt bridge; other site
1046632008305	sequence-specific DNA binding site [nucleotide binding]; other site
1046632008306	Cupin domain; Region: Cupin_2; pfam07883
1046632008307	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
1046632008308	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1046632008309	putative deacylase active site [active]
1046632008310	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1046632008311	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1046632008312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
1046632008313	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1046632008314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008315	Coenzyme A binding pocket [chemical binding]; other site
1046632008316	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1046632008317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008318	Coenzyme A binding pocket [chemical binding]; other site
1046632008319	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1046632008320	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1046632008321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1046632008322	S-adenosylmethionine binding site [chemical binding]; other site
1046632008323	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1046632008324	dimer interface [polypeptide binding]; other site
1046632008325	catalytic triad [active]
1046632008326	Cupin domain; Region: Cupin_2; cl17218
1046632008327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008328	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1046632008329	Coenzyme A binding pocket [chemical binding]; other site
1046632008330	Cupin domain; Region: Cupin_2; pfam07883
1046632008331	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1046632008332	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008333	Coenzyme A binding pocket [chemical binding]; other site
1046632008334	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1046632008335	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008336	Coenzyme A binding pocket [chemical binding]; other site
1046632008337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008338	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1046632008339	Coenzyme A binding pocket [chemical binding]; other site
1046632008340	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1046632008341	Phosphotransferase enzyme family; Region: APH; pfam01636
1046632008342	active site
1046632008343	substrate binding site [chemical binding]; other site
1046632008344	ATP binding site [chemical binding]; other site
1046632008345	classical (c) SDRs; Region: SDR_c; cd05233
1046632008346	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1046632008347	NAD(P) binding site [chemical binding]; other site
1046632008348	active site
1046632008349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008350	Coenzyme A binding pocket [chemical binding]; other site
1046632008351	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1046632008352	potential frameshift: common BLAST hit: gi|289163859|ref|YP_003453997.1| GTP cyclohydrolase
1046632008353	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1046632008354	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1046632008355	DNA binding residues [nucleotide binding]
1046632008356	dimer interface [polypeptide binding]; other site
1046632008357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1046632008358	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1046632008359	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1046632008360	Phosphotransferase enzyme family; Region: APH; pfam01636
1046632008361	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1046632008362	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1046632008363	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
1046632008364	Phosphotransferase enzyme family; Region: APH; pfam01636
1046632008365	putative active site [active]
1046632008366	putative substrate binding site [chemical binding]; other site
1046632008367	ATP binding site [chemical binding]; other site
1046632008368	shikimate kinase; Reviewed; Region: aroK; PRK00131
1046632008369	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1046632008370	ADP binding site [chemical binding]; other site
1046632008371	magnesium binding site [ion binding]; other site
1046632008372	putative shikimate binding site; other site
1046632008373	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1046632008374	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1046632008375	DNA binding residues [nucleotide binding]
1046632008376	dimerization interface [polypeptide binding]; other site
1046632008377	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1046632008378	active site
1046632008379	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1046632008380	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1046632008381	hypothetical protein; Provisional; Region: PRK02268
1046632008382	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
1046632008383	putative dimer interface [polypeptide binding]; other site
1046632008384	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1046632008385	Predicted transcriptional regulator [Transcription]; Region: COG2378
1046632008386	HTH domain; Region: HTH_11; pfam08279
1046632008387	WYL domain; Region: WYL; pfam13280
1046632008388	Phosphotransferase enzyme family; Region: APH; pfam01636
1046632008389	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
1046632008390	Evidence 5 : No homology to any previously reported sequences
1046632008391	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1046632008392	active site
1046632008393	NTP binding site [chemical binding]; other site
1046632008394	metal binding triad [ion binding]; metal-binding site
1046632008395	antibiotic binding site [chemical binding]; other site
1046632008396	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1046632008397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1046632008398	dimer interface [polypeptide binding]; other site
1046632008399	phosphorylation site [posttranslational modification]
1046632008400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1046632008401	ATP binding site [chemical binding]; other site
1046632008402	Mg2+ binding site [ion binding]; other site
1046632008403	G-X-G motif; other site
1046632008404	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1046632008405	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1046632008406	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1046632008407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1046632008408	active site
1046632008409	phosphorylation site [posttranslational modification]
1046632008410	intermolecular recognition site; other site
1046632008411	dimerization interface [polypeptide binding]; other site
1046632008412	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1046632008413	DNA binding site [nucleotide binding]
1046632008414	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1046632008415	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1046632008416	dimerization interface [polypeptide binding]; other site
1046632008417	putative DNA binding site [nucleotide binding]; other site
1046632008418	putative Zn2+ binding site [ion binding]; other site
1046632008419	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1046632008420	active site
1046632008421	NTP binding site [chemical binding]; other site
1046632008422	metal binding triad [ion binding]; metal-binding site
1046632008423	antibiotic binding site [chemical binding]; other site
1046632008424	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1046632008425	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1046632008426	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1046632008427	Coenzyme A binding pocket [chemical binding]; other site
1046632008428	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1046632008429	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008430	Coenzyme A binding pocket [chemical binding]; other site
1046632008431	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
1046632008432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1046632008433	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1046632008434	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1046632008435	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
1046632008436	RibD C-terminal domain; Region: RibD_C; cl17279
1046632008437	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1046632008438	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1046632008439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1046632008440	S-adenosylmethionine binding site [chemical binding]; other site
1046632008441	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1046632008442	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
1046632008443	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1046632008444	NodB motif; other site
1046632008445	putative active site [active]
1046632008446	putative catalytic site [active]
1046632008447	putative Zn binding site [ion binding]; other site
1046632008448	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1046632008449	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1046632008450	nucleophilic elbow; other site
1046632008451	catalytic triad; other site
1046632008452	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1046632008453	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1046632008454	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1046632008455	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1046632008456	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1046632008457	Beta-lactamase; Region: Beta-lactamase; pfam00144
1046632008458	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1046632008459	Beta-lactamase; Region: Beta-lactamase; pfam00144
1046632008460	Beta-lactamase; Region: Beta-lactamase; cl17358
1046632008461	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1046632008462	DNA binding residues [nucleotide binding]
1046632008463	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1046632008464	dimer interface [polypeptide binding]; other site
1046632008465	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1046632008466	Predicted ATPase [General function prediction only]; Region: COG3911
1046632008467	AAA domain; Region: AAA_28; pfam13521
1046632008468	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1046632008469	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008470	Coenzyme A binding pocket [chemical binding]; other site
1046632008471	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008472	Coenzyme A binding pocket [chemical binding]; other site
1046632008473	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008474	Coenzyme A binding pocket [chemical binding]; other site
1046632008475	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1046632008476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1046632008477	Coenzyme A binding pocket [chemical binding]; other site
1046632008478	aminoglycoside resistance protein; Provisional; Region: PRK13746
1046632008479	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1046632008480	active site
1046632008481	NTP binding site [chemical binding]; other site
1046632008482	metal binding triad [ion binding]; metal-binding site
1046632008483	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1046632008484	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1046632008485	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1046632008486	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1046632008487	Walker A/P-loop; other site
1046632008488	ATP binding site [chemical binding]; other site
1046632008489	Q-loop/lid; other site
1046632008490	ABC transporter signature motif; other site
1046632008491	Walker B; other site
1046632008492	D-loop; other site
1046632008493	H-loop/switch region; other site
1046632008494	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1046632008495	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1046632008496	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1046632008497	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1046632008498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1046632008499	PAS domain; Region: PAS_9; pfam13426
1046632008500	putative active site [active]
1046632008501	heme pocket [chemical binding]; other site
1046632008502	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1046632008503	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1046632008504	metal binding site [ion binding]; metal-binding site
1046632008505	active site
1046632008506	I-site; other site
1046632008507	potential frameshift: common BLAST hit: gi|328542935|ref|YP_004303044.1| PAS/PAC sensor-containing diguanylate cyclase
1046632008508	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
1046632008509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1046632008510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1046632008511	metal binding site [ion binding]; metal-binding site
1046632008512	active site
1046632008513	I-site; other site
1046632008514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1046632008515	phosphorylation site [posttranslational modification]
1046632008516	intermolecular recognition site; other site
1046632008517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1046632008518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1046632008519	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854
1046632008520	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
1046632008521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1046632008522	NAD(P) binding site [chemical binding]; other site
1046632008523	active site
1046632008524	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1046632008525	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1046632008526	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1046632008527	Domain of unknown function DUF302; Region: DUF302; pfam03625
1046632008528	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1046632008529	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1046632008530	catalytic residues [active]
1046632008531	catalytic nucleophile [active]
1046632008532	Presynaptic Site I dimer interface [polypeptide binding]; other site
1046632008533	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1046632008534	Synaptic Flat tetramer interface [polypeptide binding]; other site
1046632008535	Synaptic Site I dimer interface [polypeptide binding]; other site
1046632008536	DNA binding site [nucleotide binding]
1046632008537	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1046632008538	DNA-binding interface [nucleotide binding]; DNA binding site
1046632008539	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1046632008540	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1046632008541	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1046632008542	Ligand Binding Site [chemical binding]; other site
1046632008543	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1046632008544	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1046632008545	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1046632008546	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1046632008547	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1046632008548	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1046632008549	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1046632008550	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1046632008551	FIST N domain; Region: FIST; pfam08495
1046632008552	FIST C domain; Region: FIST_C; pfam10442
1046632008553	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1046632008554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1046632008555	putative substrate translocation pore; other site
1046632008556	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1046632008557	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1046632008558	HlyD family secretion protein; Region: HlyD_3; pfam13437
1046632008559	MarR family; Region: MarR_2; pfam12802
1046632008560	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1046632008561	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1046632008562	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
1046632008563	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1046632008564	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1046632008565	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1046632008566	metal binding site [ion binding]; metal-binding site
1046632008567	active site
1046632008568	I-site; other site
1046632008569	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1046632008570	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1046632008571	HlyD family secretion protein; Region: HlyD_3; pfam13437
1046632008572	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1046632008573	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1046632008574	Walker A/P-loop; other site
1046632008575	ATP binding site [chemical binding]; other site
1046632008576	Q-loop/lid; other site
1046632008577	ABC transporter signature motif; other site
1046632008578	Walker B; other site
1046632008579	D-loop; other site
1046632008580	H-loop/switch region; other site
1046632008581	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1046632008582	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1046632008583	Walker A/P-loop; other site
1046632008584	ATP binding site [chemical binding]; other site
1046632008585	Q-loop/lid; other site
1046632008586	ABC transporter signature motif; other site
1046632008587	Walker B; other site
1046632008588	D-loop; other site
1046632008589	H-loop/switch region; other site
1046632008590	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1046632008591	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1046632008592	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1046632008593	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1046632008594	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1046632008595	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
1046632008596	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
1046632008597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1046632008598	Transposase; Region: HTH_Tnp_1; cl17663
1046632008599	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1046632008600	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1046632008601	putative dimer interface [polypeptide binding]; other site
1046632008602	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
1046632008603	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin
1046632008604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1046632008605	PemK-like protein; Region: PemK; pfam02452
1046632008606	WGR domain; Region: WGR; cl01581
1046632008607	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1046632008608	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1046632008609	catalytic residues [active]
1046632008610	catalytic nucleophile [active]
1046632008611	Presynaptic Site I dimer interface [polypeptide binding]; other site
1046632008612	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1046632008613	Synaptic Flat tetramer interface [polypeptide binding]; other site
1046632008614	Synaptic Site I dimer interface [polypeptide binding]; other site
1046632008615	DNA binding site [nucleotide binding]
1046632008616	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
1046632008617	RelB antitoxin; Region: RelB; cl01171
1046632008618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
1046632008619	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1046632008620	ATP binding site [chemical binding]; other site
1046632008621	putative Mg++ binding site [ion binding]; other site
1046632008622	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1046632008623	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1046632008624	salt bridge; other site
1046632008625	non-specific DNA binding site [nucleotide binding]; other site
1046632008626	sequence-specific DNA binding site [nucleotide binding]; other site
1046632008627	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1046632008628	Domain of unknown function (DUF932); Region: DUF932; cl12129
1046632008629	Plasmid conjugative transfer entry exclusion protein TraS; Region: TraS; pfam10624
1046632008630	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
1046632008631	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
1046632008632	AAA domain; Region: AAA_30; pfam13604
1046632008633	AAA domain; Region: AAA_30; pfam13604
1046632008634	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1046632008635	active site
1046632008636	metal binding site [ion binding]; metal-binding site
1046632008637	interdomain interaction site; other site
1046632008638	type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759
1046632008639	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1046632008640	Walker A motif; other site
1046632008641	ATP binding site [chemical binding]; other site
1046632008642	Walker B motif; other site
1046632008643	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
1046632008644	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
1046632008645	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1046632008646	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1046632008647	catalytic residues [active]
1046632008648	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
1046632008649	F plasmid transfer operon protein; Region: TraF; pfam13728
1046632008650	type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750
1046632008651	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
1046632008652	TraU protein; Region: TraU; cl06067
1046632008653	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
1046632008654	Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; cl11515
1046632008655	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
1046632008656	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
1046632008657	Domain of unknown function DUF87; Region: DUF87; pfam01935
1046632008658	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1046632008659	TraK protein; Region: TraK; pfam06586
1046632008660	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
1046632008661	TraE protein; Region: TraE; cl05060
1046632008662	TraL protein; Region: TraL; cl06278
1046632008663	TraA; Region: TraA; cl11503
1046632008664	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
1046632008665	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
1046632008666	Global regulator protein family; Region: CsrA; pfam02599
1046632008667	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1046632008668	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1046632008669	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1046632008670	ligand binding site [chemical binding]; other site
1046632008671	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1046632008672	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1046632008673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1046632008674	ATP binding site [chemical binding]; other site
1046632008675	Mg2+ binding site [ion binding]; other site
1046632008676	G-X-G motif; other site
1046632008677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1046632008678	active site
1046632008679	phosphorylation site [posttranslational modification]
1046632008680	intermolecular recognition site; other site