-- dump date 20140619_130532 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272624000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272624000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272624000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624000004 Walker A motif; other site 272624000005 ATP binding site [chemical binding]; other site 272624000006 Walker B motif; other site 272624000007 arginine finger; other site 272624000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272624000009 DnaA box-binding interface [nucleotide binding]; other site 272624000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 272624000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272624000012 putative DNA binding surface [nucleotide binding]; other site 272624000013 dimer interface [polypeptide binding]; other site 272624000014 beta-clamp/clamp loader binding surface; other site 272624000015 beta-clamp/translesion DNA polymerase binding surface; other site 272624000016 recombination protein F; Reviewed; Region: recF; PRK00064 272624000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624000018 Walker A/P-loop; other site 272624000019 ATP binding site [chemical binding]; other site 272624000020 Q-loop/lid; other site 272624000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624000022 ABC transporter signature motif; other site 272624000023 Walker B; other site 272624000024 D-loop; other site 272624000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272624000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624000027 Mg2+ binding site [ion binding]; other site 272624000028 G-X-G motif; other site 272624000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272624000030 anchoring element; other site 272624000031 dimer interface [polypeptide binding]; other site 272624000032 ATP binding site [chemical binding]; other site 272624000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272624000034 active site 272624000035 putative metal-binding site [ion binding]; other site 272624000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272624000037 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 272624000038 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 272624000039 arginine decarboxylase; Provisional; Region: PRK05354 272624000040 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 272624000041 dimer interface [polypeptide binding]; other site 272624000042 active site 272624000043 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272624000044 catalytic residues [active] 272624000045 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 272624000046 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 272624000047 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 272624000048 putative active site; other site 272624000049 catalytic triad [active] 272624000050 putative dimer interface [polypeptide binding]; other site 272624000051 bacterial Hfq-like; Region: Hfq; cd01716 272624000052 hexamer interface [polypeptide binding]; other site 272624000053 Sm1 motif; other site 272624000054 RNA binding site [nucleotide binding]; other site 272624000055 Sm2 motif; other site 272624000056 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272624000057 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272624000058 HflX GTPase family; Region: HflX; cd01878 272624000059 G1 box; other site 272624000060 GTP/Mg2+ binding site [chemical binding]; other site 272624000061 Switch I region; other site 272624000062 G2 box; other site 272624000063 G3 box; other site 272624000064 Switch II region; other site 272624000065 G4 box; other site 272624000066 G5 box; other site 272624000067 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 272624000068 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272624000069 catalytic residues [active] 272624000070 Pirin-related protein [General function prediction only]; Region: COG1741 272624000071 Pirin; Region: Pirin; pfam02678 272624000072 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272624000073 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272624000074 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272624000075 active site 272624000076 nucleophile elbow; other site 272624000077 Patatin phospholipase; Region: DUF3734; pfam12536 272624000078 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272624000079 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624000080 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624000081 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272624000082 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272624000083 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 272624000084 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272624000085 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 272624000086 active site 272624000087 Zn binding site [ion binding]; other site 272624000088 hypothetical protein; Provisional; Region: PRK05255 272624000089 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 272624000090 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272624000091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624000092 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272624000093 Protein of unknown function (DUF962); Region: DUF962; cl01879 272624000094 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 272624000095 amino acid transporter; Region: 2A0306; TIGR00909 272624000096 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272624000097 Phosphate transporter family; Region: PHO4; pfam01384 272624000098 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 272624000099 diiron binding motif [ion binding]; other site 272624000100 PAS domain; Region: PAS_9; pfam13426 272624000101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624000102 putative active site [active] 272624000103 heme pocket [chemical binding]; other site 272624000104 PAS domain S-box; Region: sensory_box; TIGR00229 272624000105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624000106 putative active site [active] 272624000107 heme pocket [chemical binding]; other site 272624000108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624000109 PAS domain; Region: PAS_9; pfam13426 272624000110 putative active site [active] 272624000111 heme pocket [chemical binding]; other site 272624000112 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624000113 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624000114 metal binding site [ion binding]; metal-binding site 272624000115 active site 272624000116 I-site; other site 272624000117 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624000118 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 272624000119 Peptidase family M28; Region: Peptidase_M28; pfam04389 272624000120 active site 272624000121 metal binding site [ion binding]; metal-binding site 272624000122 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 272624000123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624000124 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624000125 substrate binding pocket [chemical binding]; other site 272624000126 membrane-bound complex binding site; other site 272624000127 hinge residues; other site 272624000128 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624000129 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624000130 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 272624000131 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 272624000132 active site 272624000133 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 272624000134 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272624000135 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 272624000136 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 272624000137 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 272624000138 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272624000139 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 272624000140 trimer interface [polypeptide binding]; other site 272624000141 active site 272624000142 substrate binding site [chemical binding]; other site 272624000143 CoA binding site [chemical binding]; other site 272624000144 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272624000145 amino acid transporter; Region: 2A0306; TIGR00909 272624000146 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 272624000147 Predicted membrane protein [Function unknown]; Region: COG2323 272624000148 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272624000149 tetramer interface [polypeptide binding]; other site 272624000150 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 272624000151 active site 272624000152 Mg2+/Mn2+ binding site [ion binding]; other site 272624000153 Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981 272624000154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624000155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624000156 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272624000157 dimerization interface [polypeptide binding]; other site 272624000158 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 272624000159 putative active site [active] 272624000160 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 272624000161 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 272624000162 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 272624000163 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 272624000164 DNA binding residues [nucleotide binding] 272624000165 dimer interface [polypeptide binding]; other site 272624000166 mercury binding site [ion binding]; other site 272624000167 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 272624000168 Predicted membrane protein [Function unknown]; Region: COG3428 272624000169 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 272624000170 active site 272624000171 SAM binding site [chemical binding]; other site 272624000172 homodimer interface [polypeptide binding]; other site 272624000173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624000174 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 272624000175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624000176 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 272624000177 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 272624000178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624000179 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272624000180 EamA-like transporter family; Region: EamA; pfam00892 272624000181 EamA-like transporter family; Region: EamA; pfam00892 272624000182 aspartate aminotransferase; Provisional; Region: PRK05764 272624000183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272624000184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624000185 homodimer interface [polypeptide binding]; other site 272624000186 catalytic residue [active] 272624000187 excinuclease ABC subunit B; Provisional; Region: PRK05298 272624000188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624000189 ATP binding site [chemical binding]; other site 272624000190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624000191 nucleotide binding region [chemical binding]; other site 272624000192 ATP-binding site [chemical binding]; other site 272624000193 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272624000194 UvrB/uvrC motif; Region: UVR; pfam02151 272624000195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624000196 metal binding site [ion binding]; metal-binding site 272624000197 active site 272624000198 I-site; other site 272624000199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624000200 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 272624000201 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272624000202 active site 272624000203 FMN binding site [chemical binding]; other site 272624000204 substrate binding site [chemical binding]; other site 272624000205 3Fe-4S cluster binding site [ion binding]; other site 272624000206 Cell division protein ZapA; Region: ZapA; pfam05164 272624000207 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 272624000208 proline aminopeptidase P II; Provisional; Region: PRK10879 272624000209 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 272624000210 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 272624000211 active site 272624000212 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272624000213 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 272624000214 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 272624000215 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272624000216 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 272624000217 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 272624000218 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 272624000219 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 272624000220 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 272624000221 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624000222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624000223 substrate binding pocket [chemical binding]; other site 272624000224 membrane-bound complex binding site; other site 272624000225 hinge residues; other site 272624000226 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 272624000227 ribonuclease R; Region: RNase_R; TIGR02063 272624000228 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272624000229 RNB domain; Region: RNB; pfam00773 272624000230 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272624000231 RNA binding site [nucleotide binding]; other site 272624000232 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 272624000233 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272624000234 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272624000235 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272624000236 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272624000237 active site 272624000238 dimer interface [polypeptide binding]; other site 272624000239 5' nucleotidase family; Region: 5_nucleotid; cl17687 272624000240 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 272624000241 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 272624000242 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272624000243 PhnA protein; Region: PhnA; pfam03831 272624000244 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272624000245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624000246 active site 272624000247 phosphorylation site [posttranslational modification] 272624000248 intermolecular recognition site; other site 272624000249 DNA polymerase I; Provisional; Region: PRK05755 272624000250 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272624000251 active site 272624000252 metal binding site 1 [ion binding]; metal-binding site 272624000253 putative 5' ssDNA interaction site; other site 272624000254 metal binding site 3; metal-binding site 272624000255 metal binding site 2 [ion binding]; metal-binding site 272624000256 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272624000257 putative DNA binding site [nucleotide binding]; other site 272624000258 putative metal binding site [ion binding]; other site 272624000259 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 272624000260 active site 272624000261 catalytic site [active] 272624000262 substrate binding site [chemical binding]; other site 272624000263 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272624000264 active site 272624000265 DNA binding site [nucleotide binding] 272624000266 catalytic site [active] 272624000267 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272624000268 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272624000269 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272624000270 trimer interface [polypeptide binding]; other site 272624000271 active site 272624000272 UDP-GlcNAc binding site [chemical binding]; other site 272624000273 lipid binding site [chemical binding]; lipid-binding site 272624000274 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272624000275 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272624000276 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272624000277 dimer interface [polypeptide binding]; other site 272624000278 active site 272624000279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624000280 Coenzyme A binding pocket [chemical binding]; other site 272624000281 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272624000282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624000283 Coenzyme A binding pocket [chemical binding]; other site 272624000284 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 272624000285 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272624000286 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272624000287 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 272624000288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272624000289 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 272624000290 substrate binding pocket [chemical binding]; other site 272624000291 substrate-Mg2+ binding site; other site 272624000292 aspartate-rich region 1; other site 272624000293 aspartate-rich region 2; other site 272624000294 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 272624000295 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624000296 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272624000297 tetramer interface [polypeptide binding]; other site 272624000298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624000299 catalytic residue [active] 272624000300 YCII-related domain; Region: YCII; cl00999 272624000301 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 272624000302 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272624000303 tetramer interface [polypeptide binding]; other site 272624000304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624000305 catalytic residue [active] 272624000306 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272624000307 lipoyl attachment site [posttranslational modification]; other site 272624000308 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 272624000309 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272624000310 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 272624000311 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624000312 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 272624000313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624000314 dimer interface [polypeptide binding]; other site 272624000315 conserved gate region; other site 272624000316 putative PBP binding loops; other site 272624000317 ABC-ATPase subunit interface; other site 272624000318 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 272624000319 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272624000320 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272624000321 Walker A/P-loop; other site 272624000322 ATP binding site [chemical binding]; other site 272624000323 Q-loop/lid; other site 272624000324 ABC transporter signature motif; other site 272624000325 Walker B; other site 272624000326 D-loop; other site 272624000327 H-loop/switch region; other site 272624000328 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 272624000329 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 272624000330 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272624000331 catalytic residues [active] 272624000332 hinge region; other site 272624000333 alpha helical domain; other site 272624000334 Cytochrome c553 [Energy production and conversion]; Region: COG2863 272624000335 Cytochrome c; Region: Cytochrom_C; cl11414 272624000336 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272624000337 G1 box; other site 272624000338 GTP/Mg2+ binding site [chemical binding]; other site 272624000339 Switch I region; other site 272624000340 G2 box; other site 272624000341 G3 box; other site 272624000342 Switch II region; other site 272624000343 G4 box; other site 272624000344 G5 box; other site 272624000345 acetyl-CoA synthetase; Provisional; Region: PRK00174 272624000346 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 272624000347 active site 272624000348 CoA binding site [chemical binding]; other site 272624000349 acyl-activating enzyme (AAE) consensus motif; other site 272624000350 AMP binding site [chemical binding]; other site 272624000351 acetate binding site [chemical binding]; other site 272624000352 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272624000353 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 272624000354 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 272624000355 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 272624000356 tetrameric interface [polypeptide binding]; other site 272624000357 NAD binding site [chemical binding]; other site 272624000358 catalytic residues [active] 272624000359 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272624000360 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272624000361 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272624000362 ProQ/FINO family; Region: ProQ; smart00945 272624000363 putative RNA binding sites [nucleotide binding]; other site 272624000364 MltA specific insert domain; Region: MltA; cl08398 272624000365 Peptidase S46; Region: Peptidase_S46; pfam10459 272624000366 pyruvate kinase; Provisional; Region: PRK05826 272624000367 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272624000368 domain interfaces; other site 272624000369 active site 272624000370 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272624000371 Phosphoglycerate kinase; Region: PGK; pfam00162 272624000372 substrate binding site [chemical binding]; other site 272624000373 hinge regions; other site 272624000374 ADP binding site [chemical binding]; other site 272624000375 catalytic site [active] 272624000376 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272624000377 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272624000378 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272624000379 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272624000380 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272624000381 TPP-binding site [chemical binding]; other site 272624000382 dimer interface [polypeptide binding]; other site 272624000383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272624000384 PYR/PP interface [polypeptide binding]; other site 272624000385 dimer interface [polypeptide binding]; other site 272624000386 TPP binding site [chemical binding]; other site 272624000387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272624000388 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 272624000389 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272624000390 active site 272624000391 Zn binding site [ion binding]; other site 272624000392 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 272624000393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624000394 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624000396 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624000397 Integrase core domain; Region: rve; pfam00665 272624000398 Integrase core domain; Region: rve_2; pfam13333 272624000399 Transposase; Region: HTH_Tnp_1; pfam01527 272624000400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272624000401 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 272624000402 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 272624000403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624000404 Coenzyme A binding pocket [chemical binding]; other site 272624000405 PAS domain; Region: PAS_9; pfam13426 272624000406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624000407 putative active site [active] 272624000408 heme pocket [chemical binding]; other site 272624000409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624000410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624000411 metal binding site [ion binding]; metal-binding site 272624000412 active site 272624000413 I-site; other site 272624000414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624000415 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272624000416 active site 272624000417 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 272624000418 Uncharacterized conserved protein [Function unknown]; Region: COG0432 272624000419 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272624000420 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272624000421 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272624000422 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 272624000423 Protein of unknown function (DUF808); Region: DUF808; pfam05661 272624000424 RF-1 domain; Region: RF-1; pfam00472 272624000425 Protein of unknown function (DUF330); Region: DUF330; pfam03886 272624000426 mce related protein; Region: MCE; pfam02470 272624000427 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272624000428 Permease; Region: Permease; pfam02405 272624000429 F-box-like; Region: F-box-like; pfam12937 272624000430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624000431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624000432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272624000433 dimerization interface [polypeptide binding]; other site 272624000434 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 272624000435 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 272624000436 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 272624000437 substrate binding pocket [chemical binding]; other site 272624000438 active site 272624000439 iron coordination sites [ion binding]; other site 272624000440 hypothetical protein; Provisional; Region: PRK07190 272624000441 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272624000442 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272624000443 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272624000444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624000445 putative substrate translocation pore; other site 272624000446 hypothetical protein; Provisional; Region: PRK07206 272624000447 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 272624000448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624000449 S-adenosylmethionine binding site [chemical binding]; other site 272624000450 M48 family peptidase; Provisional; Region: PRK03001 272624000451 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 272624000452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272624000453 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272624000454 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272624000455 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272624000456 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272624000457 Walker A/P-loop; other site 272624000458 ATP binding site [chemical binding]; other site 272624000459 Q-loop/lid; other site 272624000460 ABC transporter signature motif; other site 272624000461 Walker B; other site 272624000462 D-loop; other site 272624000463 H-loop/switch region; other site 272624000464 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272624000465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272624000466 TM-ABC transporter signature motif; other site 272624000467 hypothetical protein; Provisional; Region: PRK09133 272624000468 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 272624000469 putative metal binding site [ion binding]; other site 272624000470 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 272624000471 CoA-transferase family III; Region: CoA_transf_3; pfam02515 272624000472 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272624000473 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272624000474 putative dimer interface [polypeptide binding]; other site 272624000475 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 272624000476 dimer interface [polypeptide binding]; other site 272624000477 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 272624000478 active site 272624000479 heme binding site [chemical binding]; other site 272624000480 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 272624000481 Uncharacterized conserved protein [Function unknown]; Region: COG0393 272624000482 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272624000483 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272624000484 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272624000485 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 272624000486 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 272624000487 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 272624000488 DAK2 domain; Region: Dak2; pfam02734 272624000489 EDD domain protein, DegV family; Region: DegV; TIGR00762 272624000490 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272624000491 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272624000492 classical (c) SDRs; Region: SDR_c; cd05233 272624000493 NAD(P) binding site [chemical binding]; other site 272624000494 active site 272624000495 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 272624000496 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 272624000497 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 272624000498 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272624000499 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272624000500 active site 272624000501 ATP binding site [chemical binding]; other site 272624000502 substrate binding site [chemical binding]; other site 272624000503 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272624000504 substrate binding site [chemical binding]; other site 272624000505 activation loop (A-loop); other site 272624000506 activation loop (A-loop); other site 272624000507 TspO/MBR family; Region: TspO_MBR; pfam03073 272624000508 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 272624000509 DNA photolyase; Region: DNA_photolyase; pfam00875 272624000510 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 272624000511 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 272624000512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624000513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624000514 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 272624000515 putative dimerization interface [polypeptide binding]; other site 272624000516 Domain of unknown function (DUF329); Region: DUF329; pfam03884 272624000517 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272624000518 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272624000519 NAD binding site [chemical binding]; other site 272624000520 ATP-grasp domain; Region: ATP-grasp; pfam02222 272624000521 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272624000522 Nitrogen regulatory protein P-II; Region: P-II; cl00412 272624000523 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 272624000524 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 272624000525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272624000526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624000527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624000528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272624000529 dimerization interface [polypeptide binding]; other site 272624000530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624000531 ATP binding site [chemical binding]; other site 272624000532 Q-loop/lid; other site 272624000533 ABC transporter signature motif; other site 272624000534 Walker B; other site 272624000535 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272624000536 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624000537 Outer membrane efflux protein; Region: OEP; pfam02321 272624000538 Outer membrane efflux protein; Region: OEP; pfam02321 272624000539 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272624000540 hypothetical protein; Provisional; Region: PHA02764 272624000541 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 272624000542 heme binding pocket [chemical binding]; other site 272624000543 heme ligand [chemical binding]; other site 272624000544 CHASE3 domain; Region: CHASE3; pfam05227 272624000545 GAF domain; Region: GAF_3; pfam13492 272624000546 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624000547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624000548 metal binding site [ion binding]; metal-binding site 272624000549 active site 272624000550 I-site; other site 272624000551 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272624000552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624000553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624000554 motif II; other site 272624000555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272624000556 metal binding site 2 [ion binding]; metal-binding site 272624000557 putative DNA binding helix; other site 272624000558 metal binding site 1 [ion binding]; metal-binding site 272624000559 dimer interface [polypeptide binding]; other site 272624000560 structural Zn2+ binding site [ion binding]; other site 272624000561 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 272624000562 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272624000563 PYR/PP interface [polypeptide binding]; other site 272624000564 dimer interface [polypeptide binding]; other site 272624000565 TPP binding site [chemical binding]; other site 272624000566 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272624000567 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 272624000568 TPP-binding site [chemical binding]; other site 272624000569 dimer interface [polypeptide binding]; other site 272624000570 Dot/Icm substrate protein; Region: SidE; pfam12252 272624000571 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 272624000572 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 272624000573 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 272624000574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272624000575 tetramerization interface [polypeptide binding]; other site 272624000576 NAD(P) binding site [chemical binding]; other site 272624000577 catalytic residues [active] 272624000578 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 272624000579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272624000580 inhibitor-cofactor binding pocket; inhibition site 272624000581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624000582 catalytic residue [active] 272624000583 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 272624000584 glutaminase A; Region: Gln_ase; TIGR03814 272624000585 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272624000586 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272624000587 NAD binding site [chemical binding]; other site 272624000588 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 272624000589 putative NAD(P) binding site [chemical binding]; other site 272624000590 homodimer interface [polypeptide binding]; other site 272624000591 mercuric reductase; Validated; Region: PRK06370 272624000592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624000593 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272624000594 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 272624000595 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 272624000596 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272624000597 ArsC family; Region: ArsC; pfam03960 272624000598 catalytic residues [active] 272624000599 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272624000600 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 272624000601 Di-iron ligands [ion binding]; other site 272624000602 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624000603 helicase 45; Provisional; Region: PTZ00424 272624000604 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272624000605 ATP binding site [chemical binding]; other site 272624000606 Mg++ binding site [ion binding]; other site 272624000607 motif III; other site 272624000608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624000609 nucleotide binding region [chemical binding]; other site 272624000610 ATP-binding site [chemical binding]; other site 272624000611 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 272624000612 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 272624000613 hypothetical protein; Provisional; Region: PRK11212 272624000614 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272624000615 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272624000616 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272624000617 HlyD family secretion protein; Region: HlyD; pfam00529 272624000618 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624000619 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624000620 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272624000621 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272624000622 Fe-S cluster binding site [ion binding]; other site 272624000623 active site 272624000624 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 272624000625 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272624000626 amidase catalytic site [active] 272624000627 Zn binding residues [ion binding]; other site 272624000628 substrate binding site [chemical binding]; other site 272624000629 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272624000630 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 272624000631 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272624000632 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272624000633 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272624000634 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 272624000635 oligomer interface [polypeptide binding]; other site 272624000636 metal binding site [ion binding]; metal-binding site 272624000637 metal binding site [ion binding]; metal-binding site 272624000638 putative Cl binding site [ion binding]; other site 272624000639 aspartate ring; other site 272624000640 hydrophobic gate; other site 272624000641 basic sphincter; other site 272624000642 periplasmic entrance; other site 272624000643 HD domain; Region: HD_3; pfam13023 272624000644 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 272624000645 Zonular occludens toxin (Zot); Region: Zot; cl17485 272624000646 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272624000647 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272624000648 active site 272624000649 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 272624000650 Isochorismatase family; Region: Isochorismatase; pfam00857 272624000651 catalytic triad [active] 272624000652 metal binding site [ion binding]; metal-binding site 272624000653 conserved cis-peptide bond; other site 272624000654 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 272624000655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272624000656 metal binding site [ion binding]; metal-binding site 272624000657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624000658 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272624000659 putative substrate translocation pore; other site 272624000660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624000661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624000662 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272624000663 putative effector binding pocket; other site 272624000664 dimerization interface [polypeptide binding]; other site 272624000665 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 272624000666 Ras interaction site [polypeptide binding]; other site 272624000667 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272624000668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624000669 active site 272624000670 phosphorylation site [posttranslational modification] 272624000671 intermolecular recognition site; other site 272624000672 dimerization interface [polypeptide binding]; other site 272624000673 PAS domain; Region: PAS; smart00091 272624000674 PAS fold; Region: PAS_7; pfam12860 272624000675 putative active site [active] 272624000676 heme pocket [chemical binding]; other site 272624000677 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624000678 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624000679 metal binding site [ion binding]; metal-binding site 272624000680 active site 272624000681 I-site; other site 272624000682 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624000683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624000684 PAS fold; Region: PAS_3; pfam08447 272624000685 putative active site [active] 272624000686 heme pocket [chemical binding]; other site 272624000687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624000688 ATP binding site [chemical binding]; other site 272624000689 Mg2+ binding site [ion binding]; other site 272624000690 G-X-G motif; other site 272624000691 FIST N domain; Region: FIST; pfam08495 272624000692 Uncharacterized conserved protein [Function unknown]; Region: COG3287 272624000693 FIST C domain; Region: FIST_C; pfam10442 272624000694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624000695 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 272624000696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272624000697 dimerization interface [polypeptide binding]; other site 272624000698 amino acid transporter; Region: 2A0306; TIGR00909 272624000699 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272624000700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624000701 S-adenosylmethionine binding site [chemical binding]; other site 272624000702 formate dehydrogenase; Provisional; Region: PRK07574 272624000703 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 272624000704 dimerization interface [polypeptide binding]; other site 272624000705 ligand binding site [chemical binding]; other site 272624000706 NAD binding site [chemical binding]; other site 272624000707 catalytic site [active] 272624000708 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272624000709 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 272624000710 putative NAD(P) binding site [chemical binding]; other site 272624000711 homodimer interface [polypeptide binding]; other site 272624000712 homotetramer interface [polypeptide binding]; other site 272624000713 active site 272624000714 elongation factor P; Validated; Region: PRK00529 272624000715 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272624000716 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272624000717 RNA binding site [nucleotide binding]; other site 272624000718 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272624000719 RNA binding site [nucleotide binding]; other site 272624000720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 272624000721 Radical SAM superfamily; Region: Radical_SAM; pfam04055 272624000722 polyphosphate kinase; Provisional; Region: PRK05443 272624000723 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272624000724 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272624000725 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272624000726 putative active site [active] 272624000727 catalytic site [active] 272624000728 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 272624000729 putative domain interface [polypeptide binding]; other site 272624000730 putative active site [active] 272624000731 catalytic site [active] 272624000732 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272624000733 nucleophile elbow; other site 272624000734 Chromate transporter; Region: Chromate_transp; pfam02417 272624000735 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 272624000736 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 272624000737 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272624000738 active site 272624000739 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 272624000740 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 272624000741 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 272624000742 Substrate binding site; other site 272624000743 metal-binding site 272624000744 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 272624000745 Phosphotransferase enzyme family; Region: APH; pfam01636 272624000746 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 272624000747 OstA-like protein; Region: OstA; cl00844 272624000748 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272624000749 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 272624000750 SurA N-terminal domain; Region: SurA_N; pfam09312 272624000751 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272624000752 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272624000753 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 272624000754 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272624000755 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272624000756 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272624000757 folate binding site [chemical binding]; other site 272624000758 NADP+ binding site [chemical binding]; other site 272624000759 Repeats found in Drosophila proteins; Region: DM9; smart00696 272624000760 Protein of unknown function (DUF3421); Region: DUF3421; pfam11901 272624000761 Repeats found in Drosophila proteins; Region: DM9; smart00696 272624000762 elongation factor Tu; Reviewed; Region: PRK00049 272624000763 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272624000764 G1 box; other site 272624000765 GEF interaction site [polypeptide binding]; other site 272624000766 GTP/Mg2+ binding site [chemical binding]; other site 272624000767 Switch I region; other site 272624000768 G2 box; other site 272624000769 G3 box; other site 272624000770 Switch II region; other site 272624000771 G4 box; other site 272624000772 G5 box; other site 272624000773 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272624000774 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272624000775 Antibiotic Binding Site [chemical binding]; other site 272624000776 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 272624000777 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272624000778 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272624000779 putative homodimer interface [polypeptide binding]; other site 272624000780 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272624000781 heterodimer interface [polypeptide binding]; other site 272624000782 homodimer interface [polypeptide binding]; other site 272624000783 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272624000784 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272624000785 23S rRNA interface [nucleotide binding]; other site 272624000786 L7/L12 interface [polypeptide binding]; other site 272624000787 putative thiostrepton binding site; other site 272624000788 L25 interface [polypeptide binding]; other site 272624000789 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272624000790 mRNA/rRNA interface [nucleotide binding]; other site 272624000791 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272624000792 23S rRNA interface [nucleotide binding]; other site 272624000793 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272624000794 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272624000795 peripheral dimer interface [polypeptide binding]; other site 272624000796 core dimer interface [polypeptide binding]; other site 272624000797 L10 interface [polypeptide binding]; other site 272624000798 L11 interface [polypeptide binding]; other site 272624000799 putative EF-Tu interaction site [polypeptide binding]; other site 272624000800 putative EF-G interaction site [polypeptide binding]; other site 272624000801 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272624000802 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272624000803 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272624000804 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272624000805 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272624000806 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 272624000807 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272624000808 RPB3 interaction site [polypeptide binding]; other site 272624000809 RPB1 interaction site [polypeptide binding]; other site 272624000810 RPB11 interaction site [polypeptide binding]; other site 272624000811 RPB10 interaction site [polypeptide binding]; other site 272624000812 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 272624000813 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272624000814 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272624000815 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272624000816 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272624000817 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 272624000818 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272624000819 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272624000820 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272624000821 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272624000822 DNA binding site [nucleotide binding] 272624000823 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272624000824 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272624000825 S17 interaction site [polypeptide binding]; other site 272624000826 S8 interaction site; other site 272624000827 16S rRNA interaction site [nucleotide binding]; other site 272624000828 streptomycin interaction site [chemical binding]; other site 272624000829 23S rRNA interaction site [nucleotide binding]; other site 272624000830 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272624000831 30S ribosomal protein S7; Validated; Region: PRK05302 272624000832 elongation factor G; Reviewed; Region: PRK00007 272624000833 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272624000834 G1 box; other site 272624000835 putative GEF interaction site [polypeptide binding]; other site 272624000836 GTP/Mg2+ binding site [chemical binding]; other site 272624000837 Switch I region; other site 272624000838 G2 box; other site 272624000839 G3 box; other site 272624000840 Switch II region; other site 272624000841 G4 box; other site 272624000842 G5 box; other site 272624000843 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272624000844 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272624000845 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272624000846 elongation factor Tu; Reviewed; Region: PRK00049 272624000847 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272624000848 G1 box; other site 272624000849 GEF interaction site [polypeptide binding]; other site 272624000850 GTP/Mg2+ binding site [chemical binding]; other site 272624000851 Switch I region; other site 272624000852 G2 box; other site 272624000853 G3 box; other site 272624000854 Switch II region; other site 272624000855 G4 box; other site 272624000856 G5 box; other site 272624000857 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272624000858 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272624000859 Antibiotic Binding Site [chemical binding]; other site 272624000860 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272624000861 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272624000862 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272624000863 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272624000864 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272624000865 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272624000866 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272624000867 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272624000868 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272624000869 putative translocon binding site; other site 272624000870 protein-rRNA interface [nucleotide binding]; other site 272624000871 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272624000872 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272624000873 G-X-X-G motif; other site 272624000874 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272624000875 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272624000876 23S rRNA interface [nucleotide binding]; other site 272624000877 5S rRNA interface [nucleotide binding]; other site 272624000878 putative antibiotic binding site [chemical binding]; other site 272624000879 L25 interface [polypeptide binding]; other site 272624000880 L27 interface [polypeptide binding]; other site 272624000881 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272624000882 putative translocon interaction site; other site 272624000883 23S rRNA interface [nucleotide binding]; other site 272624000884 signal recognition particle (SRP54) interaction site; other site 272624000885 L23 interface [polypeptide binding]; other site 272624000886 trigger factor interaction site; other site 272624000887 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272624000888 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272624000889 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272624000890 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272624000891 RNA binding site [nucleotide binding]; other site 272624000892 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272624000893 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272624000894 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272624000895 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK06911 272624000896 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272624000897 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272624000898 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272624000899 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272624000900 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272624000901 23S rRNA interface [nucleotide binding]; other site 272624000902 L21e interface [polypeptide binding]; other site 272624000903 5S rRNA interface [nucleotide binding]; other site 272624000904 L27 interface [polypeptide binding]; other site 272624000905 L5 interface [polypeptide binding]; other site 272624000906 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272624000907 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272624000908 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272624000909 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272624000910 23S rRNA binding site [nucleotide binding]; other site 272624000911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272624000912 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272624000913 SecY translocase; Region: SecY; pfam00344 272624000914 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272624000915 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272624000916 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272624000917 30S ribosomal protein S11; Validated; Region: PRK05309 272624000918 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272624000919 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272624000920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272624000921 RNA binding surface [nucleotide binding]; other site 272624000922 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272624000923 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272624000924 alphaNTD homodimer interface [polypeptide binding]; other site 272624000925 alphaNTD - beta interaction site [polypeptide binding]; other site 272624000926 alphaNTD - beta' interaction site [polypeptide binding]; other site 272624000927 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272624000928 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272624000929 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272624000930 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272624000931 dimer interface [polypeptide binding]; other site 272624000932 ssDNA binding site [nucleotide binding]; other site 272624000933 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272624000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624000935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624000936 putative substrate translocation pore; other site 272624000937 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 272624000938 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 272624000939 putative NAD(P) binding site [chemical binding]; other site 272624000940 active site 272624000941 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272624000942 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272624000943 active site 2 [active] 272624000944 active site 1 [active] 272624000945 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 272624000946 active site 2 [active] 272624000947 dimer interface [polypeptide binding]; other site 272624000948 active site 1 [active] 272624000949 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272624000950 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272624000951 dimer interface [polypeptide binding]; other site 272624000952 active site 272624000953 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272624000954 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272624000955 active site 272624000956 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272624000957 putative acyl-acceptor binding pocket; other site 272624000958 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272624000959 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272624000960 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272624000961 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 272624000962 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 272624000963 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 272624000964 putative coenzyme Q binding site [chemical binding]; other site 272624000965 hypothetical protein; Validated; Region: PRK01777 272624000966 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 272624000967 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 272624000968 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624000969 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624000970 metal binding site [ion binding]; metal-binding site 272624000971 active site 272624000972 I-site; other site 272624000973 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 272624000974 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 272624000975 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 272624000976 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 272624000977 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272624000978 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272624000979 CoenzymeA binding site [chemical binding]; other site 272624000980 subunit interaction site [polypeptide binding]; other site 272624000981 PHB binding site; other site 272624000982 BON domain; Region: BON; pfam04972 272624000983 BON domain; Region: BON; pfam04972 272624000984 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624000985 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272624000986 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272624000987 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272624000988 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272624000989 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 272624000990 heat shock protein HtpX; Provisional; Region: PRK02870 272624000991 inner membrane transport permease; Provisional; Region: PRK15066 272624000992 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272624000993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272624000994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624000995 Walker A/P-loop; other site 272624000996 ATP binding site [chemical binding]; other site 272624000997 Q-loop/lid; other site 272624000998 ABC transporter signature motif; other site 272624000999 Walker B; other site 272624001000 D-loop; other site 272624001001 H-loop/switch region; other site 272624001002 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272624001003 Protein of unknown function DUF45; Region: DUF45; pfam01863 272624001004 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272624001005 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272624001006 DNA binding site [nucleotide binding] 272624001007 active site 272624001008 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272624001009 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272624001010 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272624001011 RimM N-terminal domain; Region: RimM; pfam01782 272624001012 PRC-barrel domain; Region: PRC; pfam05239 272624001013 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272624001014 signal recognition particle protein; Provisional; Region: PRK10867 272624001015 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272624001016 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272624001017 P loop; other site 272624001018 GTP binding site [chemical binding]; other site 272624001019 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272624001020 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001021 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001022 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001023 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001024 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001025 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 272624001026 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272624001027 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 272624001028 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 272624001029 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 272624001030 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 272624001031 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 272624001032 UbiA prenyltransferase family; Region: UbiA; pfam01040 272624001033 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 272624001034 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 272624001035 Cu(I) binding site [ion binding]; other site 272624001036 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 272624001037 RimK-like ATP-grasp domain; Region: RimK; pfam08443 272624001038 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 272624001039 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272624001040 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272624001041 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272624001042 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272624001043 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 272624001044 putative active site [active] 272624001045 phosphogluconate dehydratase; Validated; Region: PRK09054 272624001046 6-phosphogluconate dehydratase; Region: edd; TIGR01196 272624001047 Glucokinase; Region: Glucokinase; pfam02685 272624001048 glucokinase, proteobacterial type; Region: glk; TIGR00749 272624001049 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 272624001050 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272624001051 active site 272624001052 intersubunit interface [polypeptide binding]; other site 272624001053 catalytic residue [active] 272624001054 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272624001055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001056 putative substrate translocation pore; other site 272624001057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001058 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 272624001059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624001060 salt bridge; other site 272624001061 non-specific DNA binding site [nucleotide binding]; other site 272624001062 sequence-specific DNA binding site [nucleotide binding]; other site 272624001063 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 272624001064 ferrochelatase; Reviewed; Region: hemH; PRK00035 272624001065 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 272624001066 active site 272624001067 C-terminal domain interface [polypeptide binding]; other site 272624001068 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 272624001069 active site 272624001070 N-terminal domain interface [polypeptide binding]; other site 272624001071 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272624001072 DNA-binding site [nucleotide binding]; DNA binding site 272624001073 RNA-binding motif; other site 272624001074 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272624001075 HIT family signature motif; other site 272624001076 catalytic residue [active] 272624001077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272624001078 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272624001079 active site 272624001080 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272624001081 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272624001082 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624001083 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624001084 Predicted membrane protein [Function unknown]; Region: COG1289 272624001085 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272624001086 Predicted transcriptional regulators [Transcription]; Region: COG1733 272624001087 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272624001088 Uncharacterized conserved protein [Function unknown]; Region: COG4278 272624001089 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272624001090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624001091 S-adenosylmethionine binding site [chemical binding]; other site 272624001092 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001093 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001094 Protein of unknown function (DUF3773); Region: DUF3773; pfam12608 272624001095 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; pfam09475 272624001096 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 272624001097 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272624001098 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272624001099 ligand binding site [chemical binding]; other site 272624001100 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624001101 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 272624001102 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272624001103 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272624001104 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272624001105 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272624001106 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 272624001107 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 272624001108 HNH nucleases; Region: HNHc; smart00507 272624001109 AAA-like domain; Region: AAA_10; pfam12846 272624001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001111 metabolite-proton symporter; Region: 2A0106; TIGR00883 272624001112 putative substrate translocation pore; other site 272624001113 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 272624001114 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 272624001115 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 272624001116 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 272624001117 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272624001118 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272624001119 purine monophosphate binding site [chemical binding]; other site 272624001120 dimer interface [polypeptide binding]; other site 272624001121 putative catalytic residues [active] 272624001122 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272624001123 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272624001124 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272624001125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624001126 S-adenosylmethionine binding site [chemical binding]; other site 272624001127 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272624001128 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272624001129 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272624001130 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272624001131 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272624001132 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272624001133 carboxyltransferase (CT) interaction site; other site 272624001134 biotinylation site [posttranslational modification]; other site 272624001135 Dehydroquinase class II; Region: DHquinase_II; pfam01220 272624001136 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272624001137 trimer interface [polypeptide binding]; other site 272624001138 active site 272624001139 dimer interface [polypeptide binding]; other site 272624001140 pyruvate carboxylase subunit B; Provisional; Region: PRK14042 272624001141 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272624001142 active site 272624001143 catalytic residues [active] 272624001144 metal binding site [ion binding]; metal-binding site 272624001145 homodimer binding site [polypeptide binding]; other site 272624001146 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272624001147 carboxyltransferase (CT) interaction site; other site 272624001148 biotinylation site [posttranslational modification]; other site 272624001149 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 272624001150 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272624001151 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 272624001152 active site 272624001153 Zn binding site [ion binding]; other site 272624001154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624001155 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272624001156 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272624001157 putative catalytic site [active] 272624001158 putative metal binding site [ion binding]; other site 272624001159 putative phosphate binding site [ion binding]; other site 272624001160 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 272624001161 active site 272624001162 intersubunit interface [polypeptide binding]; other site 272624001163 catalytic residue [active] 272624001164 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 272624001165 ferredoxin-NADP reductase; Provisional; Region: PRK10926 272624001166 FAD binding pocket [chemical binding]; other site 272624001167 FAD binding motif [chemical binding]; other site 272624001168 phosphate binding motif [ion binding]; other site 272624001169 beta-alpha-beta structure motif; other site 272624001170 NAD binding pocket [chemical binding]; other site 272624001171 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 272624001172 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 272624001173 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272624001174 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272624001175 dimerization domain swap beta strand [polypeptide binding]; other site 272624001176 regulatory protein interface [polypeptide binding]; other site 272624001177 active site 272624001178 regulatory phosphorylation site [posttranslational modification]; other site 272624001179 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272624001180 30S subunit binding site; other site 272624001181 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272624001182 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 272624001183 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272624001184 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272624001185 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272624001186 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272624001187 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272624001188 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 272624001189 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272624001190 oligomer interface [polypeptide binding]; other site 272624001191 active site 272624001192 metal binding site [ion binding]; metal-binding site 272624001193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624001194 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001195 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001196 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 272624001197 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 272624001198 HflK protein; Region: hflK; TIGR01933 272624001199 FtsH protease regulator HflC; Provisional; Region: PRK11029 272624001200 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 272624001201 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272624001202 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272624001203 GDP-binding site [chemical binding]; other site 272624001204 ACT binding site; other site 272624001205 IMP binding site; other site 272624001206 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 272624001207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272624001208 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272624001209 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 272624001210 GIY-YIG motif/motif A; other site 272624001211 putative active site [active] 272624001212 putative metal binding site [ion binding]; other site 272624001213 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272624001214 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624001215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624001216 substrate binding pocket [chemical binding]; other site 272624001217 membrane-bound complex binding site; other site 272624001218 hinge residues; other site 272624001219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624001220 dimer interface [polypeptide binding]; other site 272624001221 conserved gate region; other site 272624001222 putative PBP binding loops; other site 272624001223 ABC-ATPase subunit interface; other site 272624001224 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 272624001225 ATP-binding cassette domain of the binding protein-dependent transport systems; Region: ABC_Class3; cd03229 272624001226 Walker A/P-loop; other site 272624001227 ATP binding site [chemical binding]; other site 272624001228 Q-loop/lid; other site 272624001229 ABC transporter signature motif; other site 272624001230 Walker B; other site 272624001231 D-loop; other site 272624001232 H-loop/switch region; other site 272624001233 argininosuccinate synthase; Provisional; Region: PRK13820 272624001234 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 272624001235 ANP binding site [chemical binding]; other site 272624001236 Substrate Binding Site II [chemical binding]; other site 272624001237 Substrate Binding Site I [chemical binding]; other site 272624001238 Lyase; Region: Lyase_1; pfam00206 272624001239 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272624001240 active sites [active] 272624001241 tetramer interface [polypeptide binding]; other site 272624001242 ornithine carbamoyltransferase; Provisional; Region: PRK00779 272624001243 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272624001244 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272624001245 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272624001246 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272624001247 active site 272624001248 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272624001249 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272624001250 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272624001251 C-terminal peptidase (prc); Region: prc; TIGR00225 272624001252 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272624001253 protein binding site [polypeptide binding]; other site 272624001254 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272624001255 Catalytic dyad [active] 272624001256 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272624001257 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 272624001258 Peptidase family M23; Region: Peptidase_M23; pfam01551 272624001259 phosphoglyceromutase; Provisional; Region: PRK05434 272624001260 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272624001261 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 272624001262 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 272624001263 catalytic residue [active] 272624001264 putative FPP diphosphate binding site; other site 272624001265 putative FPP binding hydrophobic cleft; other site 272624001266 dimer interface [polypeptide binding]; other site 272624001267 putative IPP diphosphate binding site; other site 272624001268 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 272624001269 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272624001270 zinc metallopeptidase RseP; Provisional; Region: PRK10779 272624001271 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272624001272 active site 272624001273 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272624001274 protein binding site [polypeptide binding]; other site 272624001275 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272624001276 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272624001277 putative substrate binding region [chemical binding]; other site 272624001278 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 272624001279 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272624001280 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272624001281 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272624001282 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272624001283 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272624001284 Surface antigen; Region: Bac_surface_Ag; pfam01103 272624001285 periplasmic chaperone; Provisional; Region: PRK10780 272624001286 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 272624001287 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272624001288 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272624001289 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272624001290 trimer interface [polypeptide binding]; other site 272624001291 active site 272624001292 UDP-GlcNAc binding site [chemical binding]; other site 272624001293 lipid binding site [chemical binding]; lipid-binding site 272624001294 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272624001295 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 272624001296 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272624001297 active site 272624001298 camphor resistance protein CrcB; Provisional; Region: PRK14217 272624001299 seryl-tRNA synthetase; Provisional; Region: PRK05431 272624001300 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272624001301 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272624001302 dimer interface [polypeptide binding]; other site 272624001303 active site 272624001304 motif 1; other site 272624001305 motif 2; other site 272624001306 motif 3; other site 272624001307 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272624001308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272624001309 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 272624001310 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 272624001311 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272624001312 Methyltransferase domain; Region: Methyltransf_12; pfam08242 272624001313 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272624001314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272624001315 active site 272624001316 catalytic tetrad [active] 272624001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624001318 S-adenosylmethionine binding site [chemical binding]; other site 272624001319 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272624001320 hypothetical protein; Provisional; Region: PRK08233 272624001321 AAA domain; Region: AAA_18; pfam13238 272624001322 active site 272624001323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272624001324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624001325 Coenzyme A binding pocket [chemical binding]; other site 272624001326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272624001327 RDD family; Region: RDD; pfam06271 272624001328 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 272624001329 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 272624001330 Iron-sulfur protein interface; other site 272624001331 proximal quinone binding site [chemical binding]; other site 272624001332 SdhD (CybS) interface [polypeptide binding]; other site 272624001333 proximal heme binding site [chemical binding]; other site 272624001334 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 272624001335 SdhC subunit interface [polypeptide binding]; other site 272624001336 proximal heme binding site [chemical binding]; other site 272624001337 cardiolipin binding site; other site 272624001338 Iron-sulfur protein interface; other site 272624001339 proximal quinone binding site [chemical binding]; other site 272624001340 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 272624001341 L-aspartate oxidase; Provisional; Region: PRK06175 272624001342 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272624001343 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272624001344 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272624001345 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272624001346 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272624001347 TPP-binding site [chemical binding]; other site 272624001348 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272624001349 dimer interface [polypeptide binding]; other site 272624001350 PYR/PP interface [polypeptide binding]; other site 272624001351 TPP binding site [chemical binding]; other site 272624001352 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272624001353 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272624001354 E3 interaction surface; other site 272624001355 lipoyl attachment site [posttranslational modification]; other site 272624001356 e3 binding domain; Region: E3_binding; pfam02817 272624001357 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272624001358 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272624001359 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272624001360 CoA-ligase; Region: Ligase_CoA; pfam00549 272624001361 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272624001362 CoA binding domain; Region: CoA_binding; smart00881 272624001363 CoA-ligase; Region: Ligase_CoA; pfam00549 272624001364 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 272624001365 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272624001366 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 272624001367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001368 D-galactonate transporter; Region: 2A0114; TIGR00893 272624001369 putative substrate translocation pore; other site 272624001370 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 272624001371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 272624001372 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272624001373 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272624001374 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272624001375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624001376 active site 272624001377 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 272624001378 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 272624001379 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272624001380 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272624001381 active site 272624001382 (T/H)XGH motif; other site 272624001383 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272624001384 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272624001385 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272624001386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272624001387 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272624001388 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272624001389 ligand binding site [chemical binding]; other site 272624001390 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 272624001391 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272624001392 putative acyl-acceptor binding pocket; other site 272624001393 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 272624001394 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 272624001395 Phosphotransferase enzyme family; Region: APH; pfam01636 272624001396 putative active site [active] 272624001397 putative substrate binding site [chemical binding]; other site 272624001398 ATP binding site [chemical binding]; other site 272624001399 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272624001400 active site 272624001401 DNA polymerase IV; Validated; Region: PRK02406 272624001402 DNA binding site [nucleotide binding] 272624001403 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272624001404 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272624001405 DNA binding site [nucleotide binding] 272624001406 catalytic residue [active] 272624001407 H2TH interface [polypeptide binding]; other site 272624001408 putative catalytic residues [active] 272624001409 turnover-facilitating residue; other site 272624001410 intercalation triad [nucleotide binding]; other site 272624001411 8OG recognition residue [nucleotide binding]; other site 272624001412 putative reading head residues; other site 272624001413 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272624001414 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272624001415 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 272624001416 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272624001417 Di-iron ligands [ion binding]; other site 272624001418 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624001419 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 272624001420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624001421 NAD(P) binding site [chemical binding]; other site 272624001422 active site 272624001423 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 272624001424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624001425 NAD(P) binding site [chemical binding]; other site 272624001426 active site 272624001427 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 272624001428 Phasin protein; Region: Phasin_2; cl11491 272624001429 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 272624001430 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 272624001431 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 272624001432 putative peptidase; Provisional; Region: PRK11649 272624001433 Peptidase family M23; Region: Peptidase_M23; pfam01551 272624001434 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272624001435 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272624001436 active site 272624001437 HIGH motif; other site 272624001438 dimer interface [polypeptide binding]; other site 272624001439 KMSKS motif; other site 272624001440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272624001441 RNA binding surface [nucleotide binding]; other site 272624001442 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272624001443 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272624001444 trimer interface [polypeptide binding]; other site 272624001445 putative metal binding site [ion binding]; other site 272624001446 glutathione reductase; Validated; Region: PRK06116 272624001447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272624001448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624001449 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272624001450 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 272624001451 adenosine deaminase; Provisional; Region: PRK09358 272624001452 active site 272624001453 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272624001454 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272624001455 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 272624001456 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272624001457 hypothetical protein; Validated; Region: PRK00228 272624001458 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272624001459 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272624001460 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272624001461 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272624001462 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 272624001463 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272624001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624001465 Walker A motif; other site 272624001466 ATP binding site [chemical binding]; other site 272624001467 Walker B motif; other site 272624001468 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272624001469 Membrane fusogenic activity; Region: BMFP; pfam04380 272624001470 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 272624001471 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272624001472 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272624001473 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272624001474 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272624001475 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 272624001476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624001477 catalytic residue [active] 272624001478 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272624001479 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272624001480 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272624001481 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 272624001482 putative acyl-acceptor binding pocket; other site 272624001483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272624001484 acyl-activating enzyme (AAE) consensus motif; other site 272624001485 AMP binding site [chemical binding]; other site 272624001486 active site 272624001487 CoA binding site [chemical binding]; other site 272624001488 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 272624001489 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272624001490 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272624001491 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 272624001492 Transcriptional regulator; Region: Rrf2; pfam02082 272624001493 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272624001494 putative ABC transporter; Region: ycf24; CHL00085 272624001495 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272624001496 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272624001497 Walker A/P-loop; other site 272624001498 ATP binding site [chemical binding]; other site 272624001499 Q-loop/lid; other site 272624001500 ABC transporter signature motif; other site 272624001501 Walker B; other site 272624001502 D-loop; other site 272624001503 H-loop/switch region; other site 272624001504 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 272624001505 FeS assembly protein SufD; Region: sufD; TIGR01981 272624001506 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 272624001507 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272624001508 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272624001509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624001510 catalytic residue [active] 272624001511 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272624001512 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272624001513 trimerization site [polypeptide binding]; other site 272624001514 active site 272624001515 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 272624001516 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272624001517 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 272624001518 motif 1; other site 272624001519 dimer interface [polypeptide binding]; other site 272624001520 active site 272624001521 motif 2; other site 272624001522 motif 3; other site 272624001523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624001524 S-adenosylmethionine binding site [chemical binding]; other site 272624001525 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 272624001526 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272624001527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001528 putative substrate translocation pore; other site 272624001529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624001530 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272624001531 Domain of unknown function DUF21; Region: DUF21; pfam01595 272624001532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272624001533 Transporter associated domain; Region: CorC_HlyC; smart01091 272624001534 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272624001535 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 272624001536 putative NAD(P) binding site [chemical binding]; other site 272624001537 putative substrate binding site [chemical binding]; other site 272624001538 catalytic Zn binding site [ion binding]; other site 272624001539 structural Zn binding site [ion binding]; other site 272624001540 dimer interface [polypeptide binding]; other site 272624001541 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 272624001542 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272624001543 active site 272624001544 catalytic residues [active] 272624001545 metal binding site [ion binding]; metal-binding site 272624001546 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272624001547 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272624001548 DNA binding residues [nucleotide binding] 272624001549 dimer interface [polypeptide binding]; other site 272624001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 272624001551 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 272624001552 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 272624001553 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 272624001554 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272624001555 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272624001556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272624001557 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 272624001558 Cupin domain; Region: Cupin_2; cl17218 272624001559 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 272624001560 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272624001561 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 272624001562 Competence protein; Region: Competence; pfam03772 272624001563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272624001564 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272624001565 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 272624001566 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 272624001567 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 272624001568 PilX N-terminal; Region: PilX_N; pfam14341 272624001569 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272624001570 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 272624001571 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 272624001572 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272624001573 Type II transport protein GspH; Region: GspH; pfam12019 272624001574 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272624001575 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 272624001576 NodB motif; other site 272624001577 putative active site [active] 272624001578 putative catalytic site [active] 272624001579 putative Zn binding site [ion binding]; other site 272624001580 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272624001581 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272624001582 thymidine kinase; Provisional; Region: PRK04296 272624001583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624001585 putative substrate translocation pore; other site 272624001586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001587 putative substrate translocation pore; other site 272624001588 D-galactonate transporter; Region: 2A0114; TIGR00893 272624001589 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272624001590 phosphopentomutase; Provisional; Region: PRK05362 272624001591 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272624001592 active site 272624001593 HslU subunit interaction site [polypeptide binding]; other site 272624001594 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272624001595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624001596 Walker A motif; other site 272624001597 ATP binding site [chemical binding]; other site 272624001598 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272624001599 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272624001600 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 272624001601 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 272624001602 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272624001603 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272624001604 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 272624001605 putative active site [active] 272624001606 putative catalytic site [active] 272624001607 putative DNA binding site [nucleotide binding]; other site 272624001608 putative phosphate binding site [ion binding]; other site 272624001609 metal binding site A [ion binding]; metal-binding site 272624001610 putative AP binding site [nucleotide binding]; other site 272624001611 putative metal binding site B [ion binding]; other site 272624001612 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272624001613 putative catalytic site [active] 272624001614 putative phosphate binding site [ion binding]; other site 272624001615 active site 272624001616 metal binding site A [ion binding]; metal-binding site 272624001617 DNA binding site [nucleotide binding] 272624001618 putative AP binding site [nucleotide binding]; other site 272624001619 putative metal binding site B [ion binding]; other site 272624001620 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272624001621 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272624001622 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272624001623 putative NAD(P) binding site [chemical binding]; other site 272624001624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001625 putative substrate translocation pore; other site 272624001626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624001627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624001628 putative substrate translocation pore; other site 272624001629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624001630 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 272624001631 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 272624001632 aromatic amino acid transport protein; Region: araaP; TIGR00837 272624001633 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 272624001634 aromatic amino acid transport protein; Region: araaP; TIGR00837 272624001635 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272624001636 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272624001637 ligand binding site [chemical binding]; other site 272624001638 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624001639 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624001640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272624001641 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272624001642 Walker A/P-loop; other site 272624001643 ATP binding site [chemical binding]; other site 272624001644 Q-loop/lid; other site 272624001645 ABC transporter signature motif; other site 272624001646 Walker B; other site 272624001647 D-loop; other site 272624001648 H-loop/switch region; other site 272624001649 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272624001650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624001651 Walker A/P-loop; other site 272624001652 ATP binding site [chemical binding]; other site 272624001653 Q-loop/lid; other site 272624001654 ABC transporter signature motif; other site 272624001655 Walker B; other site 272624001656 D-loop; other site 272624001657 H-loop/switch region; other site 272624001658 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272624001659 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272624001660 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272624001661 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272624001662 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272624001663 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272624001664 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272624001665 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272624001666 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272624001667 catalytic residue [active] 272624001668 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272624001669 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272624001670 substrate binding site [chemical binding]; other site 272624001671 hexamer interface [polypeptide binding]; other site 272624001672 metal binding site [ion binding]; metal-binding site 272624001673 DoxX; Region: DoxX; pfam07681 272624001674 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 272624001675 hypothetical protein; Provisional; Region: PRK05409 272624001676 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 272624001677 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272624001678 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272624001679 nucleophile elbow; other site 272624001680 DoxX; Region: DoxX; pfam07681 272624001681 Predicted membrane protein [Function unknown]; Region: COG2259 272624001682 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272624001683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624001684 acetoacetate decarboxylase; Provisional; Region: PRK02265 272624001685 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 272624001686 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272624001687 cyclase homology domain; Region: CHD; cd07302 272624001688 nucleotidyl binding site; other site 272624001689 metal binding site [ion binding]; metal-binding site 272624001690 dimer interface [polypeptide binding]; other site 272624001691 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 272624001692 hypothetical protein; Provisional; Region: PRK05409 272624001693 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624001694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624001695 substrate binding pocket [chemical binding]; other site 272624001696 membrane-bound complex binding site; other site 272624001697 hinge residues; other site 272624001698 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 272624001699 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272624001700 metal binding triad; other site 272624001701 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272624001702 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272624001703 metal binding triad; other site 272624001704 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624001705 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624001706 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624001707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272624001708 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272624001709 Walker A/P-loop; other site 272624001710 ATP binding site [chemical binding]; other site 272624001711 Q-loop/lid; other site 272624001712 ABC transporter signature motif; other site 272624001713 Walker B; other site 272624001714 D-loop; other site 272624001715 H-loop/switch region; other site 272624001716 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272624001717 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272624001718 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 272624001719 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272624001720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624001721 FeS/SAM binding site; other site 272624001722 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 272624001723 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 272624001724 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 272624001725 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272624001726 DsbD alpha interface [polypeptide binding]; other site 272624001727 catalytic residues [active] 272624001728 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272624001729 oligomerisation interface [polypeptide binding]; other site 272624001730 mobile loop; other site 272624001731 roof hairpin; other site 272624001732 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272624001733 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272624001734 ring oligomerisation interface [polypeptide binding]; other site 272624001735 ATP/Mg binding site [chemical binding]; other site 272624001736 stacking interactions; other site 272624001737 hinge regions; other site 272624001738 Ferritin-like domain; Region: Ferritin; pfam00210 272624001739 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272624001740 dimerization interface [polypeptide binding]; other site 272624001741 DPS ferroxidase diiron center [ion binding]; other site 272624001742 ion pore; other site 272624001743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624001744 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272624001745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624001746 Mg2+ binding site [ion binding]; other site 272624001747 G-X-G motif; other site 272624001748 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272624001749 anchoring element; other site 272624001750 dimer interface [polypeptide binding]; other site 272624001751 ATP binding site [chemical binding]; other site 272624001752 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272624001753 active site 272624001754 metal binding site [ion binding]; metal-binding site 272624001755 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272624001756 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272624001757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272624001758 Walker A/P-loop; other site 272624001759 ATP binding site [chemical binding]; other site 272624001760 Q-loop/lid; other site 272624001761 ABC transporter signature motif; other site 272624001762 Walker B; other site 272624001763 D-loop; other site 272624001764 H-loop/switch region; other site 272624001765 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272624001766 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272624001767 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272624001768 Walker A/P-loop; other site 272624001769 ATP binding site [chemical binding]; other site 272624001770 Q-loop/lid; other site 272624001771 ABC transporter signature motif; other site 272624001772 Walker B; other site 272624001773 D-loop; other site 272624001774 H-loop/switch region; other site 272624001775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272624001776 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272624001777 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272624001778 dimer interface [polypeptide binding]; other site 272624001779 motif 1; other site 272624001780 active site 272624001781 motif 2; other site 272624001782 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272624001783 putative deacylase active site [active] 272624001784 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272624001785 active site 272624001786 motif 3; other site 272624001787 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272624001788 anticodon binding site; other site 272624001789 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 272624001790 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001791 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001792 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001793 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624001794 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624001795 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272624001796 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272624001797 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 272624001798 active site clefts [active] 272624001799 zinc binding site [ion binding]; other site 272624001800 dimer interface [polypeptide binding]; other site 272624001801 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 272624001802 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 272624001803 Ligand Binding Site [chemical binding]; other site 272624001804 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 272624001805 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 272624001806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624001807 S-adenosylmethionine binding site [chemical binding]; other site 272624001808 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272624001809 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272624001810 substrate-cofactor binding pocket; other site 272624001811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624001812 catalytic residue [active] 272624001813 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 272624001814 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272624001815 NAD(P) binding site [chemical binding]; other site 272624001816 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272624001817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624001818 Walker A/P-loop; other site 272624001819 ATP binding site [chemical binding]; other site 272624001820 Q-loop/lid; other site 272624001821 ABC transporter signature motif; other site 272624001822 Walker B; other site 272624001823 D-loop; other site 272624001824 H-loop/switch region; other site 272624001825 ABC transporter; Region: ABC_tran_2; pfam12848 272624001826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624001827 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624001828 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 272624001829 Predicted transporter component [General function prediction only]; Region: COG2391 272624001830 Sulphur transport; Region: Sulf_transp; pfam04143 272624001831 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 272624001832 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624001833 formimidoylglutamase; Provisional; Region: PRK13775 272624001834 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 272624001835 putative active site [active] 272624001836 putative metal binding site [ion binding]; other site 272624001837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624001838 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 272624001839 NAD(P) binding site [chemical binding]; other site 272624001840 active site 272624001841 imidazolonepropionase; Validated; Region: PRK09356 272624001842 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 272624001843 active site 272624001844 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 272624001845 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 272624001846 Predicted membrane protein [Function unknown]; Region: COG1297 272624001847 putative oligopeptide transporter, OPT family; Region: TIGR00733 272624001848 HAMP domain; Region: HAMP; pfam00672 272624001849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624001850 dimer interface [polypeptide binding]; other site 272624001851 phosphorylation site [posttranslational modification] 272624001852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624001853 ATP binding site [chemical binding]; other site 272624001854 Mg2+ binding site [ion binding]; other site 272624001855 G-X-G motif; other site 272624001856 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 272624001857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624001858 active site 272624001859 phosphorylation site [posttranslational modification] 272624001860 intermolecular recognition site; other site 272624001861 dimerization interface [polypeptide binding]; other site 272624001862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272624001863 DNA binding site [nucleotide binding] 272624001864 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 272624001865 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272624001866 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272624001867 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272624001868 HIGH motif; other site 272624001869 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272624001870 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272624001871 active site 272624001872 KMSKS motif; other site 272624001873 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272624001874 tRNA binding surface [nucleotide binding]; other site 272624001875 anticodon binding site; other site 272624001876 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272624001877 multidrug efflux protein; Reviewed; Region: PRK09579 272624001878 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 272624001879 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624001880 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624001881 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624001882 BON domain; Region: BON; pfam04972 272624001883 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272624001884 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272624001885 dimer interface [polypeptide binding]; other site 272624001886 active site 272624001887 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272624001888 folate binding site [chemical binding]; other site 272624001889 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272624001890 ATP cone domain; Region: ATP-cone; pfam03477 272624001891 transcription antitermination factor NusB; Region: nusB; TIGR01951 272624001892 thiamine monophosphate kinase; Provisional; Region: PRK05731 272624001893 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272624001894 ATP binding site [chemical binding]; other site 272624001895 dimerization interface [polypeptide binding]; other site 272624001896 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272624001897 tetramer interfaces [polypeptide binding]; other site 272624001898 binuclear metal-binding site [ion binding]; other site 272624001899 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272624001900 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272624001901 NAD synthetase; Provisional; Region: PRK13981 272624001902 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 272624001903 multimer interface [polypeptide binding]; other site 272624001904 active site 272624001905 catalytic triad [active] 272624001906 protein interface 1 [polypeptide binding]; other site 272624001907 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272624001908 homodimer interface [polypeptide binding]; other site 272624001909 NAD binding pocket [chemical binding]; other site 272624001910 ATP binding pocket [chemical binding]; other site 272624001911 Mg binding site [ion binding]; other site 272624001912 active-site loop [active] 272624001913 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272624001914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624001915 ATP binding site [chemical binding]; other site 272624001916 putative Mg++ binding site [ion binding]; other site 272624001917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624001918 nucleotide binding region [chemical binding]; other site 272624001919 ATP-binding site [chemical binding]; other site 272624001920 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 272624001921 replicative DNA helicase; Region: DnaB; TIGR00665 272624001922 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272624001923 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272624001924 Walker A motif; other site 272624001925 ATP binding site [chemical binding]; other site 272624001926 Walker B motif; other site 272624001927 DNA binding loops [nucleotide binding] 272624001928 alanine racemase; Reviewed; Region: alr; PRK00053 272624001929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 272624001930 active site 272624001931 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272624001932 substrate binding site [chemical binding]; other site 272624001933 catalytic residues [active] 272624001934 dimer interface [polypeptide binding]; other site 272624001935 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 272624001936 FOG: CBS domain [General function prediction only]; Region: COG0517 272624001937 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 272624001938 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272624001939 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 272624001940 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 272624001941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624001942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624001943 metal binding site [ion binding]; metal-binding site 272624001944 active site 272624001945 I-site; other site 272624001946 lipoyl synthase; Provisional; Region: PRK05481 272624001947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624001948 FeS/SAM binding site; other site 272624001949 POT family; Region: PTR2; cl17359 272624001950 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272624001951 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272624001952 S-adenosylmethionine binding site [chemical binding]; other site 272624001953 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 272624001954 Ligand Binding Site [chemical binding]; other site 272624001955 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272624001956 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272624001957 substrate binding site [chemical binding]; other site 272624001958 glutamase interaction surface [polypeptide binding]; other site 272624001959 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 272624001960 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272624001961 putative active site [active] 272624001962 oxyanion strand; other site 272624001963 catalytic triad [active] 272624001964 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 272624001965 ligand binding site; other site 272624001966 tetramer interface; other site 272624001967 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 272624001968 NeuB family; Region: NeuB; pfam03102 272624001969 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 272624001970 NeuB binding interface [polypeptide binding]; other site 272624001971 putative substrate binding site [chemical binding]; other site 272624001972 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 272624001973 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272624001974 active site 272624001975 homodimer interface [polypeptide binding]; other site 272624001976 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 272624001977 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 272624001978 putative trimer interface [polypeptide binding]; other site 272624001979 putative CoA binding site [chemical binding]; other site 272624001980 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 272624001981 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 272624001982 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272624001983 inhibitor-cofactor binding pocket; inhibition site 272624001984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624001985 catalytic residue [active] 272624001986 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 272624001987 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272624001988 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 272624001989 NADP binding site [chemical binding]; other site 272624001990 active site 272624001991 putative substrate binding site [chemical binding]; other site 272624001992 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 272624001993 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272624001994 NAD binding site [chemical binding]; other site 272624001995 substrate binding site [chemical binding]; other site 272624001996 homodimer interface [polypeptide binding]; other site 272624001997 active site 272624001998 Phosphoglucose isomerase; Region: PGI; pfam00342 272624001999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624002000 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272624002001 active site 272624002002 dimer interface [polypeptide binding]; other site 272624002003 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272624002004 dimer interface [polypeptide binding]; other site 272624002005 active site 272624002006 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272624002007 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272624002008 substrate binding site; other site 272624002009 tetramer interface; other site 272624002010 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272624002011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624002012 NAD(P) binding site [chemical binding]; other site 272624002013 active site 272624002014 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 272624002015 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 272624002016 Mg++ binding site [ion binding]; other site 272624002017 putative catalytic motif [active] 272624002018 putative substrate binding site [chemical binding]; other site 272624002019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624002020 binding surface 272624002021 TPR motif; other site 272624002022 Putative methyltransferase; Region: Methyltransf_4; cl17290 272624002023 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272624002024 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272624002025 substrate binding site [chemical binding]; other site 272624002026 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 272624002027 NeuB family; Region: NeuB; pfam03102 272624002028 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 272624002029 NeuB binding interface [polypeptide binding]; other site 272624002030 putative substrate binding site [chemical binding]; other site 272624002031 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272624002032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624002033 S-adenosylmethionine binding site [chemical binding]; other site 272624002034 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 272624002035 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272624002036 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272624002037 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272624002038 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272624002039 Walker A/P-loop; other site 272624002040 ATP binding site [chemical binding]; other site 272624002041 Q-loop/lid; other site 272624002042 ABC transporter signature motif; other site 272624002043 Walker B; other site 272624002044 D-loop; other site 272624002045 H-loop/switch region; other site 272624002046 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 272624002047 putative carbohydrate binding site [chemical binding]; other site 272624002048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272624002049 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272624002050 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272624002051 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272624002052 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272624002053 Probable Catalytic site; other site 272624002054 metal-binding site 272624002055 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272624002056 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272624002057 Probable Catalytic site; other site 272624002058 metal-binding site 272624002059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272624002060 carbon storage regulator; Provisional; Region: PRK01712 272624002061 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272624002062 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 272624002063 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272624002064 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 272624002065 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272624002066 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272624002067 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272624002068 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272624002069 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 272624002070 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 272624002071 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272624002072 Ligand Binding Site [chemical binding]; other site 272624002073 TilS substrate binding domain; Region: TilS; pfam09179 272624002074 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 272624002075 Transposase IS200 like; Region: Y1_Tnp; cl00848 272624002076 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 272624002077 active site 272624002078 oxyanion hole [active] 272624002079 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 272624002080 catalytic triad [active] 272624002081 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272624002082 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 272624002083 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272624002084 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272624002085 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 272624002086 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 272624002087 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272624002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624002089 muropeptide transporter; Reviewed; Region: ampG; PRK11902 272624002090 putative substrate translocation pore; other site 272624002091 Transposase; Region: HTH_Tnp_1; pfam01527 272624002092 HTH-like domain; Region: HTH_21; pfam13276 272624002093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272624002094 Integrase core domain; Region: rve; pfam00665 272624002095 Integrase core domain; Region: rve_3; pfam13683 272624002096 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 272624002097 Quinolinate synthetase A protein; Region: NadA; pfam02445 272624002098 L-aspartate oxidase; Provisional; Region: PRK09077 272624002099 L-aspartate oxidase; Provisional; Region: PRK06175 272624002100 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272624002101 adenylosuccinate lyase; Provisional; Region: PRK09285 272624002102 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 272624002103 tetramer interface [polypeptide binding]; other site 272624002104 active site 272624002105 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272624002106 putative transporter; Provisional; Region: PRK11660 272624002107 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272624002108 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272624002109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272624002110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272624002111 active site 272624002112 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 272624002113 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 272624002114 active site 272624002115 phosphoenolpyruvate synthase; Validated; Region: PRK06464 272624002116 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272624002117 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272624002118 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272624002119 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272624002120 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272624002121 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272624002122 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 272624002123 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272624002124 dimerization interface [polypeptide binding]; other site 272624002125 active site 272624002126 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 272624002127 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272624002128 active site 272624002129 homodimer interface [polypeptide binding]; other site 272624002130 hypothetical protein; Provisional; Region: PRK08201 272624002131 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 272624002132 metal binding site [ion binding]; metal-binding site 272624002133 putative dimer interface [polypeptide binding]; other site 272624002134 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272624002135 rod shape-determining protein MreB; Provisional; Region: PRK13927 272624002136 MreB and similar proteins; Region: MreB_like; cd10225 272624002137 nucleotide binding site [chemical binding]; other site 272624002138 Mg binding site [ion binding]; other site 272624002139 putative protofilament interaction site [polypeptide binding]; other site 272624002140 RodZ interaction site [polypeptide binding]; other site 272624002141 rod shape-determining protein MreC; Provisional; Region: PRK13922 272624002142 rod shape-determining protein MreC; Region: MreC; pfam04085 272624002143 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 272624002144 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 272624002145 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272624002146 active site 272624002147 isocitrate dehydrogenase; Validated; Region: PRK07362 272624002148 isocitrate dehydrogenase; Reviewed; Region: PRK07006 272624002149 Uncharacterized conserved protein [Function unknown]; Region: COG2127 272624002150 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 272624002151 Clp amino terminal domain; Region: Clp_N; pfam02861 272624002152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624002153 Walker A motif; other site 272624002154 ATP binding site [chemical binding]; other site 272624002155 Walker B motif; other site 272624002156 arginine finger; other site 272624002157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624002158 Walker A motif; other site 272624002159 ATP binding site [chemical binding]; other site 272624002160 Walker B motif; other site 272624002161 arginine finger; other site 272624002162 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272624002163 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272624002164 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 272624002165 GIY-YIG motif/motif A; other site 272624002166 putative active site [active] 272624002167 putative metal binding site [ion binding]; other site 272624002168 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272624002169 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272624002170 putative metal binding site; other site 272624002171 O-Antigen ligase; Region: Wzy_C; cl04850 272624002172 Rhomboid family; Region: Rhomboid; cl11446 272624002173 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272624002174 Peptidase family M23; Region: Peptidase_M23; pfam01551 272624002175 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272624002176 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272624002177 generic binding surface II; other site 272624002178 generic binding surface I; other site 272624002179 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272624002180 Sporulation related domain; Region: SPOR; pfam05036 272624002181 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 272624002182 biofilm formation regulator HmsP; Provisional; Region: PRK11829 272624002183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272624002184 dimerization interface [polypeptide binding]; other site 272624002185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624002186 metal binding site [ion binding]; metal-binding site 272624002187 active site 272624002188 I-site; other site 272624002189 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624002190 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 272624002191 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 272624002192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272624002193 hypothetical protein; Provisional; Region: PRK06194 272624002194 classical (c) SDRs; Region: SDR_c; cd05233 272624002195 NAD(P) binding site [chemical binding]; other site 272624002196 active site 272624002197 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272624002198 active site 272624002199 ribulose/triose binding site [chemical binding]; other site 272624002200 phosphate binding site [ion binding]; other site 272624002201 substrate (anthranilate) binding pocket [chemical binding]; other site 272624002202 product (indole) binding pocket [chemical binding]; other site 272624002203 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 272624002204 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272624002205 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272624002206 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272624002207 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272624002208 glutamine binding [chemical binding]; other site 272624002209 catalytic triad [active] 272624002210 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 272624002211 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272624002212 Walker A/P-loop; other site 272624002213 ATP binding site [chemical binding]; other site 272624002214 Q-loop/lid; other site 272624002215 ABC transporter signature motif; other site 272624002216 Walker B; other site 272624002217 D-loop; other site 272624002218 H-loop/switch region; other site 272624002219 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 272624002220 OstA-like protein; Region: OstA; pfam03968 272624002221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 272624002222 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 272624002223 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 272624002224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624002225 active site 272624002226 motif I; other site 272624002227 motif II; other site 272624002228 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 272624002229 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272624002230 putative active site [active] 272624002231 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272624002232 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 272624002233 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272624002234 Walker A/P-loop; other site 272624002235 ATP binding site [chemical binding]; other site 272624002236 Q-loop/lid; other site 272624002237 ABC transporter signature motif; other site 272624002238 Walker B; other site 272624002239 D-loop; other site 272624002240 H-loop/switch region; other site 272624002241 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272624002242 Permease; Region: Permease; cl00510 272624002243 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272624002244 mce related protein; Region: MCE; pfam02470 272624002245 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 272624002246 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272624002247 anti sigma factor interaction site; other site 272624002248 regulatory phosphorylation site [posttranslational modification]; other site 272624002249 BolA-like protein; Region: BolA; cl00386 272624002250 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272624002251 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272624002252 hinge; other site 272624002253 active site 272624002254 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272624002255 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 272624002256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272624002257 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272624002258 Walker A/P-loop; other site 272624002259 ATP binding site [chemical binding]; other site 272624002260 Q-loop/lid; other site 272624002261 ABC transporter signature motif; other site 272624002262 Walker B; other site 272624002263 D-loop; other site 272624002264 H-loop/switch region; other site 272624002265 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272624002266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272624002267 FtsX-like permease family; Region: FtsX; pfam02687 272624002268 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624002269 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624002270 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624002271 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272624002272 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 272624002273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624002274 Walker A motif; other site 272624002275 ATP binding site [chemical binding]; other site 272624002276 Walker B motif; other site 272624002277 arginine finger; other site 272624002278 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272624002279 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 272624002280 putative inner membrane peptidase; Provisional; Region: PRK11778 272624002281 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272624002282 tandem repeat interface [polypeptide binding]; other site 272624002283 oligomer interface [polypeptide binding]; other site 272624002284 active site residues [active] 272624002285 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 272624002286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624002287 Walker A/P-loop; other site 272624002288 ATP binding site [chemical binding]; other site 272624002289 Q-loop/lid; other site 272624002290 ABC transporter signature motif; other site 272624002291 Walker B; other site 272624002292 D-loop; other site 272624002293 H-loop/switch region; other site 272624002294 CcmB protein; Region: CcmB; cl17444 272624002295 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 272624002296 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 272624002297 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 272624002298 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 272624002299 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 272624002300 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 272624002301 catalytic residues [active] 272624002302 central insert; other site 272624002303 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 272624002304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624002305 binding surface 272624002306 TPR motif; other site 272624002307 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 272624002308 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272624002309 active site 272624002310 DNA binding site [nucleotide binding] 272624002311 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 272624002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624002313 ATP binding site [chemical binding]; other site 272624002314 putative Mg++ binding site [ion binding]; other site 272624002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624002316 nucleotide binding region [chemical binding]; other site 272624002317 ATP-binding site [chemical binding]; other site 272624002318 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272624002319 HRDC domain; Region: HRDC; pfam00570 272624002320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272624002321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272624002322 active site 272624002323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272624002324 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 272624002325 substrate binding site [chemical binding]; other site 272624002326 oxyanion hole (OAH) forming residues; other site 272624002327 trimer interface [polypeptide binding]; other site 272624002328 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 272624002329 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272624002330 substrate binding site [chemical binding]; other site 272624002331 oxyanion hole (OAH) forming residues; other site 272624002332 trimer interface [polypeptide binding]; other site 272624002333 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 272624002334 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272624002335 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272624002336 G1 box; other site 272624002337 putative GEF interaction site [polypeptide binding]; other site 272624002338 GTP/Mg2+ binding site [chemical binding]; other site 272624002339 Switch I region; other site 272624002340 G2 box; other site 272624002341 G3 box; other site 272624002342 Switch II region; other site 272624002343 G4 box; other site 272624002344 G5 box; other site 272624002345 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272624002346 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 272624002347 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 272624002348 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272624002349 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272624002350 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 272624002351 ligand binding site [chemical binding]; other site 272624002352 homodimer interface [polypeptide binding]; other site 272624002353 NAD(P) binding site [chemical binding]; other site 272624002354 trimer interface B [polypeptide binding]; other site 272624002355 trimer interface A [polypeptide binding]; other site 272624002356 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 272624002357 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272624002358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272624002359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624002360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624002361 metal binding site [ion binding]; metal-binding site 272624002362 active site 272624002363 I-site; other site 272624002364 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272624002365 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272624002366 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 272624002367 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272624002368 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272624002369 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 272624002370 metal binding site [ion binding]; metal-binding site 272624002371 dimer interface [polypeptide binding]; other site 272624002372 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 272624002373 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272624002374 trimer interface [polypeptide binding]; other site 272624002375 active site 272624002376 substrate binding site [chemical binding]; other site 272624002377 CoA binding site [chemical binding]; other site 272624002378 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272624002379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 272624002380 putative acyl-acceptor binding pocket; other site 272624002381 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 272624002382 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272624002383 homodimer interface [polypeptide binding]; other site 272624002384 substrate-cofactor binding pocket; other site 272624002385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624002386 catalytic residue [active] 272624002387 PAS fold; Region: PAS_7; pfam12860 272624002388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624002389 PAS domain; Region: PAS_9; pfam13426 272624002390 putative active site [active] 272624002391 heme pocket [chemical binding]; other site 272624002392 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624002393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624002394 metal binding site [ion binding]; metal-binding site 272624002395 active site 272624002396 I-site; other site 272624002397 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624002398 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 272624002399 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272624002400 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272624002401 FAD binding domain; Region: FAD_binding_4; pfam01565 272624002402 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 272624002403 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 272624002404 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624002405 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 272624002406 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272624002407 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272624002408 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 272624002409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272624002410 minor groove reading motif; other site 272624002411 helix-hairpin-helix signature motif; other site 272624002412 substrate binding pocket [chemical binding]; other site 272624002413 active site 272624002414 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 272624002415 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272624002416 DNA binding and oxoG recognition site [nucleotide binding] 272624002417 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272624002418 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 272624002419 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272624002420 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272624002421 protein binding site [polypeptide binding]; other site 272624002422 Isochorismatase family; Region: Isochorismatase; pfam00857 272624002423 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 272624002424 catalytic triad [active] 272624002425 dimer interface [polypeptide binding]; other site 272624002426 conserved cis-peptide bond; other site 272624002427 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 272624002428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624002429 NAD(P) binding site [chemical binding]; other site 272624002430 active site 272624002431 FlgN protein; Region: FlgN; pfam05130 272624002432 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 272624002433 SAF-like; Region: SAF_2; pfam13144 272624002434 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 272624002435 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 272624002436 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624002437 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272624002438 nucleotide binding site [chemical binding]; other site 272624002439 Type III pantothenate kinase; Region: Pan_kinase; cl17198 272624002440 cell division protein MraZ; Reviewed; Region: PRK00326 272624002441 MraZ protein; Region: MraZ; pfam02381 272624002442 MraZ protein; Region: MraZ; pfam02381 272624002443 MraW methylase family; Region: Methyltransf_5; cl17771 272624002444 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272624002445 Cell division protein FtsL; Region: FtsL; cl11433 272624002446 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272624002447 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272624002448 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272624002449 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272624002450 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272624002451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272624002452 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272624002453 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 272624002454 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 272624002455 ligand binding site [chemical binding]; other site 272624002456 NAD binding site [chemical binding]; other site 272624002457 catalytic site [active] 272624002458 homodimer interface [polypeptide binding]; other site 272624002459 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 272624002460 Peptidase family M50; Region: Peptidase_M50; pfam02163 272624002461 active site 272624002462 putative substrate binding region [chemical binding]; other site 272624002463 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272624002464 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 272624002465 active site 272624002466 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 272624002467 Ligand binding site [chemical binding]; other site 272624002468 Electron transfer flavoprotein domain; Region: ETF; pfam01012 272624002469 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 272624002470 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 272624002471 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 272624002472 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272624002473 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272624002474 hexamer interface [polypeptide binding]; other site 272624002475 ligand binding site [chemical binding]; other site 272624002476 putative active site [active] 272624002477 NAD(P) binding site [chemical binding]; other site 272624002478 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 272624002479 Transglycosylase; Region: Transgly; pfam00912 272624002480 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272624002481 Cell division protein FtsA; Region: FtsA; cl17206 272624002482 Competence protein A; Region: Competence_A; pfam11104 272624002483 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272624002484 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 272624002485 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 272624002486 Pilus assembly protein, PilO; Region: PilO; pfam04350 272624002487 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 272624002488 Pilus assembly protein, PilP; Region: PilP; pfam04351 272624002489 AMIN domain; Region: AMIN; pfam11741 272624002490 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 272624002491 Secretin and TonB N terminus short domain; Region: STN; smart00965 272624002492 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272624002493 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272624002494 shikimate kinase; Reviewed; Region: aroK; PRK00131 272624002495 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272624002496 ADP binding site [chemical binding]; other site 272624002497 magnesium binding site [ion binding]; other site 272624002498 putative shikimate binding site; other site 272624002499 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272624002500 active site 272624002501 dimer interface [polypeptide binding]; other site 272624002502 metal binding site [ion binding]; metal-binding site 272624002503 AAA domain; Region: AAA_22; pfam13401 272624002504 Sporulation related domain; Region: SPOR; pfam05036 272624002505 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272624002506 Ligand Binding Site [chemical binding]; other site 272624002507 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272624002508 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272624002509 active site 272624002510 Riboflavin kinase; Region: Flavokinase; smart00904 272624002511 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272624002512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272624002513 active site 272624002514 HIGH motif; other site 272624002515 nucleotide binding site [chemical binding]; other site 272624002516 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272624002517 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272624002518 active site 272624002519 KMSKS motif; other site 272624002520 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272624002521 tRNA binding surface [nucleotide binding]; other site 272624002522 anticodon binding site; other site 272624002523 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272624002524 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 272624002525 Class I aldolases; Region: Aldolase_Class_I; cl17187 272624002526 catalytic residue [active] 272624002527 GTPase Era; Reviewed; Region: era; PRK00089 272624002528 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272624002529 G1 box; other site 272624002530 GTP/Mg2+ binding site [chemical binding]; other site 272624002531 Switch I region; other site 272624002532 G2 box; other site 272624002533 Switch II region; other site 272624002534 G3 box; other site 272624002535 G4 box; other site 272624002536 G5 box; other site 272624002537 KH domain; Region: KH_2; pfam07650 272624002538 Recombination protein O N terminal; Region: RecO_N; pfam11967 272624002539 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272624002540 Recombination protein O C terminal; Region: RecO_C; pfam02565 272624002541 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624002542 Leucine-rich repeats; other site 272624002543 Substrate binding site [chemical binding]; other site 272624002544 Leucine rich repeat; Region: LRR_8; pfam13855 272624002545 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 272624002546 active site 272624002547 hydrophilic channel; other site 272624002548 dimerization interface [polypeptide binding]; other site 272624002549 catalytic residues [active] 272624002550 active site lid [active] 272624002551 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272624002552 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 272624002553 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272624002554 dimer interface [polypeptide binding]; other site 272624002555 PYR/PP interface [polypeptide binding]; other site 272624002556 TPP binding site [chemical binding]; other site 272624002557 substrate binding site [chemical binding]; other site 272624002558 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 272624002559 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 272624002560 TPP-binding site [chemical binding]; other site 272624002561 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272624002562 YccA-like proteins; Region: YccA_like; cd10433 272624002563 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 272624002564 nitrilase; Region: PLN02798 272624002565 putative active site [active] 272624002566 catalytic triad [active] 272624002567 dimer interface [polypeptide binding]; other site 272624002568 protease TldD; Provisional; Region: tldD; PRK10735 272624002569 hypothetical protein; Provisional; Region: PRK10279 272624002570 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 272624002571 active site 272624002572 nucleophile elbow; other site 272624002573 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 272624002574 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 272624002575 acyl-activating enzyme (AAE) consensus motif; other site 272624002576 putative AMP binding site [chemical binding]; other site 272624002577 putative active site [active] 272624002578 putative CoA binding site [chemical binding]; other site 272624002579 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272624002580 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272624002581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624002582 ATP binding site [chemical binding]; other site 272624002583 putative Mg++ binding site [ion binding]; other site 272624002584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624002585 nucleotide binding region [chemical binding]; other site 272624002586 ATP-binding site [chemical binding]; other site 272624002587 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272624002588 RmuC family; Region: RmuC; pfam02646 272624002589 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272624002590 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272624002591 nucleotide binding pocket [chemical binding]; other site 272624002592 K-X-D-G motif; other site 272624002593 catalytic site [active] 272624002594 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272624002595 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272624002596 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272624002597 Dimer interface [polypeptide binding]; other site 272624002598 BRCT sequence motif; other site 272624002599 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 272624002600 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272624002601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272624002602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624002603 dimer interface [polypeptide binding]; other site 272624002604 conserved gate region; other site 272624002605 putative PBP binding loops; other site 272624002606 ABC-ATPase subunit interface; other site 272624002607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272624002608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624002609 dimer interface [polypeptide binding]; other site 272624002610 conserved gate region; other site 272624002611 putative PBP binding loops; other site 272624002612 ABC-ATPase subunit interface; other site 272624002613 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272624002614 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 272624002615 putative active site [active] 272624002616 putative PHP Thumb interface [polypeptide binding]; other site 272624002617 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272624002618 generic binding surface II; other site 272624002619 generic binding surface I; other site 272624002620 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 272624002621 UbiA prenyltransferase family; Region: UbiA; pfam01040 272624002622 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 272624002623 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 272624002624 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272624002625 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 272624002626 NAD(P) binding site [chemical binding]; other site 272624002627 homodimer interface [polypeptide binding]; other site 272624002628 substrate binding site [chemical binding]; other site 272624002629 active site 272624002630 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272624002631 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272624002632 nucleotide binding site [chemical binding]; other site 272624002633 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 272624002634 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 272624002635 Antirestriction protein (ArdA); Region: ArdA; pfam07275 272624002636 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272624002637 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272624002638 dimer interface [polypeptide binding]; other site 272624002639 ssDNA binding site [nucleotide binding]; other site 272624002640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272624002641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272624002642 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 272624002643 Integrase; Region: Integrase_1; pfam12835 272624002644 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 272624002645 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 272624002646 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 272624002647 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 272624002648 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 272624002649 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 272624002650 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 272624002651 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 272624002652 Domain of unknown function DUF87; Region: DUF87; pfam01935 272624002653 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 272624002654 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 272624002655 basic region leucin zipper; Region: BRLZ; smart00338 272624002656 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 272624002657 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 272624002658 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 272624002659 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 272624002660 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 272624002661 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 272624002662 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 272624002663 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 272624002664 Global regulator protein family; Region: CsrA; pfam02599 272624002665 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 272624002666 Outer membrane efflux protein; Region: OEP; pfam02321 272624002667 Outer membrane efflux protein; Region: OEP; pfam02321 272624002668 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 272624002669 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 272624002670 lipoyl-biotinyl attachment site [posttranslational modification]; other site 272624002671 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624002672 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 272624002673 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272624002674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624002675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624002676 motif II; other site 272624002677 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272624002678 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624002679 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272624002680 Domain of unknown function DUF302; Region: DUF302; pfam03625 272624002681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624002682 classical (c) SDRs; Region: SDR_c; cd05233 272624002683 active site 272624002684 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272624002685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624002686 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272624002687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624002688 motif II; other site 272624002689 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272624002690 Outer membrane efflux protein; Region: OEP; pfam02321 272624002691 Outer membrane efflux protein; Region: OEP; pfam02321 272624002692 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624002693 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624002694 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272624002695 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 272624002696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272624002697 Beta-Casp domain; Region: Beta-Casp; smart01027 272624002698 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272624002699 thymidine phosphorylase; Provisional; Region: PRK04350 272624002700 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272624002701 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272624002702 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 272624002703 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 272624002704 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272624002705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624002706 active site 272624002707 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272624002708 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624002709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624002710 motif II; other site 272624002711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624002712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624002713 metal binding site [ion binding]; metal-binding site 272624002714 active site 272624002715 I-site; other site 272624002716 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 272624002717 Outer membrane efflux protein; Region: OEP; pfam02321 272624002718 Outer membrane efflux protein; Region: OEP; pfam02321 272624002719 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 272624002720 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272624002721 carboxyltransferase (CT) interaction site; other site 272624002722 biotinylation site [posttranslational modification]; other site 272624002723 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624002724 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272624002725 Protein export membrane protein; Region: SecD_SecF; cl14618 272624002726 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 272624002727 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 272624002728 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272624002729 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272624002730 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272624002731 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 272624002732 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 272624002733 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 272624002734 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 272624002735 heme-binding residues [chemical binding]; other site 272624002736 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 272624002737 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272624002738 FAD binding pocket [chemical binding]; other site 272624002739 FAD binding motif [chemical binding]; other site 272624002740 phosphate binding motif [ion binding]; other site 272624002741 beta-alpha-beta structure motif; other site 272624002742 NAD binding pocket [chemical binding]; other site 272624002743 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272624002744 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272624002745 catalytic loop [active] 272624002746 iron binding site [ion binding]; other site 272624002747 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 272624002748 core domain interface [polypeptide binding]; other site 272624002749 epsilon subunit interface [polypeptide binding]; other site 272624002750 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 272624002751 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624002752 Walker A motif; other site 272624002753 ATP binding site [chemical binding]; other site 272624002754 Walker B motif; other site 272624002755 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272624002756 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 272624002757 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 272624002758 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272624002759 F0F1 ATP synthase subunit A; Provisional; Region: PRK13420 272624002760 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 272624002761 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 272624002762 gamma subunit interface [polypeptide binding]; other site 272624002763 epsilon subunit interface [polypeptide binding]; other site 272624002764 LBP interface [polypeptide binding]; other site 272624002765 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 272624002766 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272624002767 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272624002768 alpha subunit interaction interface [polypeptide binding]; other site 272624002769 Walker A motif; other site 272624002770 ATP binding site [chemical binding]; other site 272624002771 Walker B motif; other site 272624002772 inhibitor binding site; inhibition site 272624002773 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272624002774 Heme NO binding; Region: HNOB; pfam07700 272624002775 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624002776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624002777 metal binding site [ion binding]; metal-binding site 272624002778 active site 272624002779 I-site; other site 272624002780 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624002781 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 272624002782 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272624002783 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272624002784 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 272624002785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624002786 NAD(P) binding site [chemical binding]; other site 272624002787 active site 272624002788 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272624002789 DNA-binding site [nucleotide binding]; DNA binding site 272624002790 RNA-binding motif; other site 272624002791 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624002792 Sel1-like repeats; Region: SEL1; smart00671 272624002793 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624002794 Sel1-like repeats; Region: SEL1; smart00671 272624002795 Sel1-like repeats; Region: SEL1; smart00671 272624002796 Sel1-like repeats; Region: SEL1; smart00671 272624002797 Sel1 repeat; Region: Sel1; pfam08238 272624002798 Sel1-like repeats; Region: SEL1; smart00671 272624002799 citrate-proton symporter; Provisional; Region: PRK15075 272624002800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624002801 putative substrate translocation pore; other site 272624002802 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272624002803 active site 272624002804 catalytic residues [active] 272624002805 metal binding site [ion binding]; metal-binding site 272624002806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624002807 non-specific DNA binding site [nucleotide binding]; other site 272624002808 salt bridge; other site 272624002809 sequence-specific DNA binding site [nucleotide binding]; other site 272624002810 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 272624002811 Abi-like protein; Region: Abi_2; pfam07751 272624002812 integrase; Provisional; Region: PRK09692 272624002813 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272624002814 active site 272624002815 Int/Topo IB signature motif; other site 272624002816 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624002817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624002818 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 272624002819 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624002820 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 272624002821 Domain of unknown function (DUF927); Region: DUF927; pfam06048 272624002822 Helix-turn-helix domain; Region: HTH_17; cl17695 272624002823 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 272624002824 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272624002825 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 272624002826 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272624002827 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272624002828 putative active site [active] 272624002829 putative NTP binding site [chemical binding]; other site 272624002830 putative nucleic acid binding site [nucleotide binding]; other site 272624002831 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272624002832 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 272624002833 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272624002834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272624002835 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272624002836 active site 272624002837 DNA binding site [nucleotide binding] 272624002838 Int/Topo IB signature motif; other site 272624002839 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 272624002840 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272624002841 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272624002842 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272624002843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624002844 Coenzyme A binding pocket [chemical binding]; other site 272624002845 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 272624002846 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 272624002847 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272624002848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624002849 S-adenosylmethionine binding site [chemical binding]; other site 272624002850 Fic family protein [Function unknown]; Region: COG3177 272624002851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624002852 Coenzyme A binding pocket [chemical binding]; other site 272624002853 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 272624002854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624002855 motif II; other site 272624002856 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272624002857 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272624002858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624002859 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272624002860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624002861 motif II; other site 272624002862 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272624002863 Outer membrane efflux protein; Region: OEP; pfam02321 272624002864 Outer membrane efflux protein; Region: OEP; pfam02321 272624002865 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624002866 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624002867 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272624002868 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 272624002869 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272624002870 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272624002871 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 272624002872 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272624002873 Phosphotransferase enzyme family; Region: APH; pfam01636 272624002874 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272624002875 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272624002876 SelR domain; Region: SelR; pfam01641 272624002877 EamA-like transporter family; Region: EamA; cl17759 272624002878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624002879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624002880 PAS domain; Region: PAS_9; pfam13426 272624002881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624002882 PAS domain; Region: PAS_9; pfam13426 272624002883 putative active site [active] 272624002884 heme pocket [chemical binding]; other site 272624002885 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624002886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624002887 metal binding site [ion binding]; metal-binding site 272624002888 active site 272624002889 I-site; other site 272624002890 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624002891 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 272624002892 circadian clock protein KaiC; Reviewed; Region: PRK09302 272624002893 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624002894 Walker A motif; other site 272624002895 ATP binding site [chemical binding]; other site 272624002896 Walker B motif; other site 272624002897 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624002898 Walker A motif; other site 272624002899 ATP binding site [chemical binding]; other site 272624002900 Walker B motif; other site 272624002901 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 272624002902 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 272624002903 active site 272624002904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624002905 Coenzyme A binding pocket [chemical binding]; other site 272624002906 Beta-lactamase; Region: Beta-lactamase; pfam00144 272624002907 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272624002908 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 272624002909 catalytic core [active] 272624002910 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272624002911 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272624002912 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272624002913 catalytic residue [active] 272624002914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624002915 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272624002916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624002917 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624002918 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624002919 substrate binding pocket [chemical binding]; other site 272624002920 membrane-bound complex binding site; other site 272624002921 hinge residues; other site 272624002922 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624002923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624002924 substrate binding pocket [chemical binding]; other site 272624002925 membrane-bound complex binding site; other site 272624002926 hinge residues; other site 272624002927 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272624002928 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272624002929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272624002930 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272624002931 acyl-activating enzyme (AAE) consensus motif; other site 272624002932 AMP binding site [chemical binding]; other site 272624002933 active site 272624002934 CoA binding site [chemical binding]; other site 272624002935 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272624002936 nucleoside/Zn binding site; other site 272624002937 dimer interface [polypeptide binding]; other site 272624002938 catalytic motif [active] 272624002939 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272624002940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272624002941 dimerization interface [polypeptide binding]; other site 272624002942 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272624002943 cyclase homology domain; Region: CHD; cd07302 272624002944 nucleotidyl binding site; other site 272624002945 metal binding site [ion binding]; metal-binding site 272624002946 dimer interface [polypeptide binding]; other site 272624002947 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 272624002948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624002949 S-adenosylmethionine binding site [chemical binding]; other site 272624002950 Nitronate monooxygenase; Region: NMO; pfam03060 272624002951 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272624002952 FMN binding site [chemical binding]; other site 272624002953 substrate binding site [chemical binding]; other site 272624002954 putative catalytic residue [active] 272624002955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272624002956 COQ9; Region: COQ9; pfam08511 272624002957 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 272624002958 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272624002959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272624002960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272624002961 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272624002962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624002963 dimer interface [polypeptide binding]; other site 272624002964 conserved gate region; other site 272624002965 putative PBP binding loops; other site 272624002966 ABC-ATPase subunit interface; other site 272624002967 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 272624002968 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272624002969 Walker A/P-loop; other site 272624002970 ATP binding site [chemical binding]; other site 272624002971 Q-loop/lid; other site 272624002972 ABC transporter signature motif; other site 272624002973 Walker B; other site 272624002974 D-loop; other site 272624002975 H-loop/switch region; other site 272624002976 TOBE domain; Region: TOBE_2; pfam08402 272624002977 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 272624002978 GIY-YIG motif/motif A; other site 272624002979 putative active site [active] 272624002980 putative metal binding site [ion binding]; other site 272624002981 short chain dehydrogenase; Provisional; Region: PRK08219 272624002982 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272624002983 NADP binding site [chemical binding]; other site 272624002984 active site 272624002985 steroid binding site; other site 272624002986 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 272624002987 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272624002988 active site 272624002989 Zn binding site [ion binding]; other site 272624002990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624002991 Coenzyme A binding pocket [chemical binding]; other site 272624002992 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272624002993 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272624002994 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272624002995 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272624002996 DNA binding site [nucleotide binding] 272624002997 active site 272624002998 probable polyamine oxidase; Region: PLN02268 272624002999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272624003000 pyruvate decarboxylase; Region: PLN02573 272624003001 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272624003002 dimer interface [polypeptide binding]; other site 272624003003 PYR/PP interface [polypeptide binding]; other site 272624003004 TPP binding site [chemical binding]; other site 272624003005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272624003006 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 272624003007 TPP-binding site [chemical binding]; other site 272624003008 dimer interface [polypeptide binding]; other site 272624003009 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 272624003010 Peptidase family M28; Region: Peptidase_M28; pfam04389 272624003011 metal binding site [ion binding]; metal-binding site 272624003012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624003013 Putative serine esterase (DUF676); Region: DUF676; pfam05057 272624003014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624003015 active site 272624003016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003017 metabolite-proton symporter; Region: 2A0106; TIGR00883 272624003018 putative substrate translocation pore; other site 272624003019 acetylornithine deacetylase; Provisional; Region: PRK07522 272624003020 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 272624003021 metal binding site [ion binding]; metal-binding site 272624003022 putative dimer interface [polypeptide binding]; other site 272624003023 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272624003024 Sugar specificity; other site 272624003025 Pyrimidine base specificity; other site 272624003026 ATP-binding site [chemical binding]; other site 272624003027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 272624003028 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 272624003029 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624003030 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624003031 metal binding site [ion binding]; metal-binding site 272624003032 active site 272624003033 I-site; other site 272624003034 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624003035 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 272624003036 putative ligand binding pocket/active site [active] 272624003037 putative metal binding site [ion binding]; other site 272624003038 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 272624003039 AMMECR1; Region: AMMECR1; pfam01871 272624003040 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 272624003041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624003042 FeS/SAM binding site; other site 272624003043 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624003044 Sel1-like repeats; Region: SEL1; smart00671 272624003045 Sel1-like repeats; Region: SEL1; smart00671 272624003046 Sel1-like repeats; Region: SEL1; smart00671 272624003047 Sel1-like repeats; Region: SEL1; smart00671 272624003048 Sel1-like repeats; Region: SEL1; smart00671 272624003049 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624003050 Sel1-like repeats; Region: SEL1; smart00671 272624003051 Sel1-like repeats; Region: SEL1; smart00671 272624003052 Sel1-like repeats; Region: SEL1; smart00671 272624003053 Sel1-like repeats; Region: SEL1; smart00671 272624003054 Sel1-like repeats; Region: SEL1; smart00671 272624003055 Sel1-like repeats; Region: SEL1; smart00671 272624003056 Sel1-like repeats; Region: SEL1; smart00671 272624003057 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 272624003058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624003059 dimer interface [polypeptide binding]; other site 272624003060 phosphorylation site [posttranslational modification] 272624003061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624003062 ATP binding site [chemical binding]; other site 272624003063 Mg2+ binding site [ion binding]; other site 272624003064 G-X-G motif; other site 272624003065 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272624003066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624003067 active site 272624003068 phosphorylation site [posttranslational modification] 272624003069 intermolecular recognition site; other site 272624003070 dimerization interface [polypeptide binding]; other site 272624003071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624003072 Walker A motif; other site 272624003073 ATP binding site [chemical binding]; other site 272624003074 Walker B motif; other site 272624003075 arginine finger; other site 272624003076 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272624003077 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624003078 Peptidase family M48; Region: Peptidase_M48; pfam01435 272624003079 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 272624003080 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272624003081 catalytic motif [active] 272624003082 Zn binding site [ion binding]; other site 272624003083 RibD C-terminal domain; Region: RibD_C; cl17279 272624003084 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 272624003085 Lumazine binding domain; Region: Lum_binding; pfam00677 272624003086 Lumazine binding domain; Region: Lum_binding; pfam00677 272624003087 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 272624003088 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 272624003089 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272624003090 dimerization interface [polypeptide binding]; other site 272624003091 active site 272624003092 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272624003093 homopentamer interface [polypeptide binding]; other site 272624003094 active site 272624003095 CTP synthetase; Validated; Region: pyrG; PRK05380 272624003096 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272624003097 Catalytic site [active] 272624003098 active site 272624003099 UTP binding site [chemical binding]; other site 272624003100 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272624003101 active site 272624003102 putative oxyanion hole; other site 272624003103 catalytic triad [active] 272624003104 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 272624003105 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272624003106 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272624003107 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 272624003108 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 272624003109 Putative exonuclease, RdgC; Region: RdgC; pfam04381 272624003110 K+ potassium transporter; Region: K_trans; pfam02705 272624003111 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 272624003112 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 272624003113 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 272624003114 putative RNA binding site [nucleotide binding]; other site 272624003115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624003116 S-adenosylmethionine binding site [chemical binding]; other site 272624003117 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272624003118 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 272624003119 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272624003120 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 272624003121 conserved cys residue [active] 272624003122 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 272624003123 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272624003124 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272624003125 metal binding site [ion binding]; metal-binding site 272624003126 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272624003127 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272624003128 substrate binding site [chemical binding]; other site 272624003129 glutamase interaction surface [polypeptide binding]; other site 272624003130 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272624003131 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 272624003132 catalytic residues [active] 272624003133 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 272624003134 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272624003135 putative active site [active] 272624003136 oxyanion strand; other site 272624003137 catalytic triad [active] 272624003138 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 272624003139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624003140 active site 272624003141 motif I; other site 272624003142 motif II; other site 272624003143 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272624003144 putative active site pocket [active] 272624003145 4-fold oligomerization interface [polypeptide binding]; other site 272624003146 metal binding residues [ion binding]; metal-binding site 272624003147 3-fold/trimer interface [polypeptide binding]; other site 272624003148 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 272624003149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272624003150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624003151 homodimer interface [polypeptide binding]; other site 272624003152 catalytic residue [active] 272624003153 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272624003154 histidinol dehydrogenase; Region: hisD; TIGR00069 272624003155 NAD binding site [chemical binding]; other site 272624003156 dimerization interface [polypeptide binding]; other site 272624003157 product binding site; other site 272624003158 substrate binding site [chemical binding]; other site 272624003159 zinc binding site [ion binding]; other site 272624003160 catalytic residues [active] 272624003161 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 272624003162 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 272624003163 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 272624003164 identified by homology 272624003165 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 272624003166 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 272624003167 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272624003168 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272624003169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624003170 active site 272624003171 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272624003172 DNA-binding site [nucleotide binding]; DNA binding site 272624003173 RNA-binding motif; other site 272624003174 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272624003175 30S subunit binding site; other site 272624003176 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 272624003177 putative deacylase active site [active] 272624003178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272624003179 MarR family; Region: MarR_2; pfam12802 272624003180 MarR family; Region: MarR_2; cl17246 272624003181 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272624003182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272624003183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272624003184 LysE type translocator; Region: LysE; cl00565 272624003185 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272624003186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624003187 Coenzyme A binding pocket [chemical binding]; other site 272624003188 Predicted ATPase [General function prediction only]; Region: COG3911 272624003189 AAA domain; Region: AAA_28; pfam13521 272624003190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624003191 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272624003192 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 272624003193 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12619 272624003194 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 272624003195 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12628 272624003196 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272624003197 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 272624003198 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 272624003199 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 272624003200 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 272624003201 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 272624003202 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272624003203 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 272624003204 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272624003205 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 272624003206 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 272624003207 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272624003208 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 272624003209 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12701 272624003210 Flagellar L-ring protein; Region: FlgH; pfam02107 272624003211 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 272624003212 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 272624003213 Rod binding protein; Region: Rod-binding; cl01626 272624003214 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12710 272624003215 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 272624003216 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715 272624003217 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 272624003218 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 272624003219 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 272624003220 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272624003221 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272624003222 active site 272624003223 nucleophile elbow; other site 272624003224 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272624003225 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 272624003226 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272624003227 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 272624003228 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 272624003229 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272624003230 active site 272624003231 DNA binding site [nucleotide binding] 272624003232 Int/Topo IB signature motif; other site 272624003233 Uncharacterized conserved protein [Function unknown]; Region: COG2135 272624003234 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272624003235 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272624003236 Catalytic site [active] 272624003237 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272624003238 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272624003239 active site 272624003240 DNA binding site [nucleotide binding] 272624003241 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272624003242 Restriction endonuclease; Region: Mrr_cat; pfam04471 272624003243 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 272624003244 additional DNA contacts [nucleotide binding]; other site 272624003245 mismatch recognition site; other site 272624003246 active site 272624003247 zinc binding site [ion binding]; other site 272624003248 DNA intercalation site [nucleotide binding]; other site 272624003249 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 272624003250 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272624003251 DNA binding residues [nucleotide binding] 272624003252 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272624003253 cofactor binding site; other site 272624003254 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 272624003255 DNA binding site [nucleotide binding] 272624003256 substrate interaction site [chemical binding]; other site 272624003257 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 272624003258 Conjugal transfer protein TraD; Region: TraD; pfam06412 272624003259 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 272624003260 MobA/MobL family; Region: MobA_MobL; pfam03389 272624003261 AAA domain; Region: AAA_30; pfam13604 272624003262 Family description; Region: UvrD_C_2; pfam13538 272624003263 Winged helix-turn helix; Region: HTH_29; pfam13551 272624003264 Helix-turn-helix domain; Region: HTH_28; pfam13518 272624003265 Integrase core domain; Region: rve; pfam00665 272624003266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272624003267 Integrase core domain; Region: rve_3; pfam13683 272624003268 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 272624003269 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624003270 Walker A motif; other site 272624003271 ATP binding site [chemical binding]; other site 272624003272 Walker B motif; other site 272624003273 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 272624003274 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 272624003275 Walker A motif; other site 272624003276 hexamer interface [polypeptide binding]; other site 272624003277 ATP binding site [chemical binding]; other site 272624003278 Walker B motif; other site 272624003279 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272624003280 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 272624003281 VirB7 interaction site; other site 272624003282 VirB8 protein; Region: VirB8; pfam04335 272624003283 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 272624003284 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 272624003285 Type IV secretion system proteins; Region: T4SS; pfam07996 272624003286 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 272624003287 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 272624003288 Type IV secretory pathway, VirB3-like protein; Region: VirB3; pfam05101 272624003289 Global regulator protein family; Region: CsrA; pfam02599 272624003290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624003291 non-specific DNA binding site [nucleotide binding]; other site 272624003292 salt bridge; other site 272624003293 sequence-specific DNA binding site [nucleotide binding]; other site 272624003294 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272624003295 Catalytic site [active] 272624003296 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272624003297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003298 POT family; Region: PTR2; cl17359 272624003299 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 272624003300 homodimer interface [polypeptide binding]; other site 272624003301 active site 272624003302 SAM binding site [chemical binding]; other site 272624003303 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272624003304 Zn2+ binding site [ion binding]; other site 272624003305 Mg2+ binding site [ion binding]; other site 272624003306 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 272624003307 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272624003308 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272624003309 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272624003310 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 272624003311 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272624003312 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272624003313 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 272624003314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272624003315 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 272624003316 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272624003317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624003318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624003319 Walker A/P-loop; other site 272624003320 ATP binding site [chemical binding]; other site 272624003321 Q-loop/lid; other site 272624003322 ABC transporter signature motif; other site 272624003323 Walker B; other site 272624003324 D-loop; other site 272624003325 H-loop/switch region; other site 272624003326 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 272624003327 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 272624003328 malate dehydrogenase; Provisional; Region: PRK13529 272624003329 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272624003330 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272624003331 NAD(P) binding site [chemical binding]; other site 272624003332 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 272624003333 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624003334 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272624003335 Peptidase family M23; Region: Peptidase_M23; pfam01551 272624003336 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 272624003337 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272624003338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272624003339 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272624003340 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272624003341 DNA binding residues [nucleotide binding] 272624003342 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 272624003343 hypothetical protein; Validated; Region: PRK00110 272624003344 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272624003345 active site 272624003346 putative DNA-binding cleft [nucleotide binding]; other site 272624003347 dimer interface [polypeptide binding]; other site 272624003348 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272624003349 RuvA N terminal domain; Region: RuvA_N; pfam01330 272624003350 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272624003351 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272624003352 sensor protein QseC; Provisional; Region: PRK10337 272624003353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624003354 dimer interface [polypeptide binding]; other site 272624003355 phosphorylation site [posttranslational modification] 272624003356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624003357 ATP binding site [chemical binding]; other site 272624003358 Mg2+ binding site [ion binding]; other site 272624003359 G-X-G motif; other site 272624003360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624003361 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 272624003362 active site 272624003363 phosphorylation site [posttranslational modification] 272624003364 intermolecular recognition site; other site 272624003365 dimerization interface [polypeptide binding]; other site 272624003366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272624003367 DNA binding site [nucleotide binding] 272624003368 intracellular septation protein A; Reviewed; Region: PRK00259 272624003369 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272624003370 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272624003371 catalytic residue [active] 272624003372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624003373 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272624003374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624003375 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 272624003376 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624003377 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 272624003378 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 272624003379 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 272624003380 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272624003381 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272624003382 homodimer interface [polypeptide binding]; other site 272624003383 NADP binding site [chemical binding]; other site 272624003384 substrate binding site [chemical binding]; other site 272624003385 FimV N-terminal domain; Region: FimV_core; TIGR03505 272624003386 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 272624003387 heterodimer interface [polypeptide binding]; other site 272624003388 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 272624003389 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 272624003390 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 272624003391 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272624003392 putative NAD(P) binding site [chemical binding]; other site 272624003393 active site 272624003394 DoxX-like family; Region: DoxX_3; pfam13781 272624003395 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272624003396 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272624003397 dimerization interface 3.5A [polypeptide binding]; other site 272624003398 active site 272624003399 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272624003400 active site 272624003401 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272624003402 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272624003403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624003404 catalytic residue [active] 272624003405 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 272624003406 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272624003407 substrate binding site [chemical binding]; other site 272624003408 active site 272624003409 catalytic residues [active] 272624003410 heterodimer interface [polypeptide binding]; other site 272624003411 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 272624003412 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272624003413 active site 272624003414 HIGH motif; other site 272624003415 nucleotide binding site [chemical binding]; other site 272624003416 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 272624003417 KMSKS motif; other site 272624003418 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 272624003419 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272624003420 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272624003421 active site 272624003422 HIGH motif; other site 272624003423 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272624003424 KMSKS motif; other site 272624003425 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 272624003426 tRNA binding surface [nucleotide binding]; other site 272624003427 anticodon binding site; other site 272624003428 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 272624003429 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 272624003430 Sulfatase; Region: Sulfatase; pfam00884 272624003431 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 272624003432 GIY-YIG motif/motif A; other site 272624003433 putative active site [active] 272624003434 putative metal binding site [ion binding]; other site 272624003435 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 272624003436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272624003437 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272624003438 type II secretion system protein E; Region: type_II_gspE; TIGR02533 272624003439 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272624003440 Walker A motif; other site 272624003441 ATP binding site [chemical binding]; other site 272624003442 Walker B motif; other site 272624003443 Sporulation related domain; Region: SPOR; pfam05036 272624003444 type II secretion system protein D; Region: type_II_gspD; TIGR02517 272624003445 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272624003446 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272624003447 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272624003448 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272624003449 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272624003450 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272624003451 Cache domain; Region: Cache_1; pfam02743 272624003452 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272624003453 cyclase homology domain; Region: CHD; cd07302 272624003454 nucleotidyl binding site; other site 272624003455 metal binding site [ion binding]; metal-binding site 272624003456 dimer interface [polypeptide binding]; other site 272624003457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003458 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272624003459 putative substrate translocation pore; other site 272624003460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624003462 putative substrate translocation pore; other site 272624003463 IucA / IucC family; Region: IucA_IucC; pfam04183 272624003464 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272624003465 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 272624003466 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 272624003467 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 272624003468 Sporulation related domain; Region: SPOR; pfam05036 272624003469 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272624003470 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 272624003471 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272624003472 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272624003473 protein binding site [polypeptide binding]; other site 272624003474 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272624003475 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 272624003476 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272624003477 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 272624003478 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272624003479 RNA binding surface [nucleotide binding]; other site 272624003480 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272624003481 active site 272624003482 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 272624003483 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272624003484 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624003485 FeS/SAM binding site; other site 272624003486 TRAM domain; Region: TRAM; pfam01938 272624003487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003488 putative substrate translocation pore; other site 272624003489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624003490 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624003491 Flagellar protein FliS; Region: FliS; cl00654 272624003492 flagellar capping protein; Provisional; Region: PRK12765 272624003493 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 272624003494 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 272624003495 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 272624003496 flagellin; Provisional; Region: PRK12806 272624003497 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 272624003498 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 272624003499 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272624003500 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272624003501 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272624003502 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272624003503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 272624003504 Sporulation related domain; Region: SPOR; pfam05036 272624003505 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272624003506 Colicin V production protein; Region: Colicin_V; pfam02674 272624003507 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272624003508 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272624003509 active site 272624003510 (T/H)XGH motif; other site 272624003511 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272624003512 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272624003513 Lipopolysaccharide-assembly; Region: LptE; cl01125 272624003514 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272624003515 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272624003516 HIGH motif; other site 272624003517 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272624003518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272624003519 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272624003520 active site 272624003521 KMSKS motif; other site 272624003522 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272624003523 tRNA binding surface [nucleotide binding]; other site 272624003524 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 272624003525 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272624003526 putative active site [active] 272624003527 catalytic triad [active] 272624003528 putative dimer interface [polypeptide binding]; other site 272624003529 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 272624003530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624003531 aldehyde dehydrogenase family 7 member; Region: PLN02315 272624003532 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 272624003533 tetrameric interface [polypeptide binding]; other site 272624003534 NAD binding site [chemical binding]; other site 272624003535 catalytic residues [active] 272624003536 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272624003537 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272624003538 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272624003539 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 272624003540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272624003541 substrate binding site [chemical binding]; other site 272624003542 oxyanion hole (OAH) forming residues; other site 272624003543 trimer interface [polypeptide binding]; other site 272624003544 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 272624003545 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272624003546 dimer interface [polypeptide binding]; other site 272624003547 active site 272624003548 DNA-directed RNA polymerase subunit A''; Validated; Region: PRK04309 272624003549 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272624003550 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624003551 Sel1-like repeats; Region: SEL1; smart00671 272624003552 Sel1-like repeats; Region: SEL1; smart00671 272624003553 Sel1-like repeats; Region: SEL1; smart00671 272624003554 Sel1-like repeats; Region: SEL1; smart00671 272624003555 Sel1-like repeats; Region: SEL1; smart00671 272624003556 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00152 272624003557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624003558 PAS domain; Region: PAS_9; pfam13426 272624003559 putative active site [active] 272624003560 heme pocket [chemical binding]; other site 272624003561 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624003562 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624003563 metal binding site [ion binding]; metal-binding site 272624003564 active site 272624003565 I-site; other site 272624003566 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624003567 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 272624003568 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272624003569 type II secretion system protein J; Region: gspJ; TIGR01711 272624003570 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 272624003571 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 272624003572 Type II transport protein GspH; Region: GspH; pfam12019 272624003573 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272624003574 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 272624003575 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 272624003576 type II secretion system protein F; Region: GspF; TIGR02120 272624003577 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272624003578 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272624003579 glutamine synthetase; Provisional; Region: glnA; PRK09469 272624003580 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272624003581 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272624003582 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 272624003583 hypothetical protein; Validated; Region: PRK02101 272624003584 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 272624003585 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 272624003586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624003587 catalytic residue [active] 272624003588 heat shock protein 90; Provisional; Region: PRK05218 272624003589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624003590 ATP binding site [chemical binding]; other site 272624003591 Mg2+ binding site [ion binding]; other site 272624003592 G-X-G motif; other site 272624003593 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272624003594 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272624003595 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272624003596 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272624003597 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272624003598 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272624003599 RNA/DNA hybrid binding site [nucleotide binding]; other site 272624003600 active site 272624003601 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272624003602 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 272624003603 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272624003604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272624003605 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272624003606 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 272624003607 POT family; Region: PTR2; cl17359 272624003608 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 272624003609 urocanate hydratase; Provisional; Region: PRK05414 272624003610 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 272624003611 active sites [active] 272624003612 tetramer interface [polypeptide binding]; other site 272624003613 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 272624003614 NAD(P) binding site [chemical binding]; other site 272624003615 catalytic residues [active] 272624003616 short chain dehydrogenase; Provisional; Region: PRK08278 272624003617 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 272624003618 NAD(P) binding site [chemical binding]; other site 272624003619 homodimer interface [polypeptide binding]; other site 272624003620 active site 272624003621 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272624003622 RNA/DNA hybrid binding site [nucleotide binding]; other site 272624003623 active site 272624003624 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272624003625 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272624003626 active site 272624003627 catalytic site [active] 272624003628 substrate binding site [chemical binding]; other site 272624003629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272624003630 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624003631 phosphodiesterase; Provisional; Region: PRK12704 272624003632 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 272624003633 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272624003634 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272624003635 Ligand Binding Site [chemical binding]; other site 272624003636 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 272624003637 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 272624003638 putative phosphate acyltransferase; Provisional; Region: PRK05331 272624003639 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272624003640 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272624003641 dimer interface [polypeptide binding]; other site 272624003642 active site 272624003643 CoA binding pocket [chemical binding]; other site 272624003644 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272624003645 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272624003646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272624003647 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272624003648 NAD(P) binding site [chemical binding]; other site 272624003649 homotetramer interface [polypeptide binding]; other site 272624003650 homodimer interface [polypeptide binding]; other site 272624003651 active site 272624003652 acyl carrier protein; Provisional; Region: acpP; PRK00982 272624003653 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 272624003654 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272624003655 dimer interface [polypeptide binding]; other site 272624003656 active site 272624003657 YceG-like family; Region: YceG; pfam02618 272624003658 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272624003659 dimerization interface [polypeptide binding]; other site 272624003660 thymidylate kinase; Validated; Region: tmk; PRK00698 272624003661 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272624003662 TMP-binding site; other site 272624003663 ATP-binding site [chemical binding]; other site 272624003664 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 272624003665 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272624003666 PilZ domain; Region: PilZ; cl01260 272624003667 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272624003668 active site 272624003669 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 272624003670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624003672 putative substrate translocation pore; other site 272624003673 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 272624003674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003675 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 272624003676 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 272624003677 Ligand binding site; other site 272624003678 Putative Catalytic site; other site 272624003679 DXD motif; other site 272624003680 GtrA-like protein; Region: GtrA; pfam04138 272624003681 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 272624003682 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 272624003683 Phosphotransferase enzyme family; Region: APH; pfam01636 272624003684 active site 272624003685 ATP binding site [chemical binding]; other site 272624003686 substrate binding site [chemical binding]; other site 272624003687 dimer interface [polypeptide binding]; other site 272624003688 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 272624003689 active site 272624003690 catalytic site [active] 272624003691 substrate binding site [chemical binding]; other site 272624003692 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 272624003693 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272624003694 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272624003695 catalytic residue [active] 272624003696 adenylate kinase; Reviewed; Region: adk; PRK00279 272624003697 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272624003698 AMP-binding site [chemical binding]; other site 272624003699 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272624003700 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272624003701 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272624003702 catalytic residues [active] 272624003703 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 272624003704 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 272624003705 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272624003706 N- and C-terminal domain interface [polypeptide binding]; other site 272624003707 active site 272624003708 MgATP binding site [chemical binding]; other site 272624003709 catalytic site [active] 272624003710 metal binding site [ion binding]; metal-binding site 272624003711 glycerol binding site [chemical binding]; other site 272624003712 homotetramer interface [polypeptide binding]; other site 272624003713 homodimer interface [polypeptide binding]; other site 272624003714 FBP binding site [chemical binding]; other site 272624003715 protein IIAGlc interface [polypeptide binding]; other site 272624003716 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272624003717 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272624003718 dimer interface [polypeptide binding]; other site 272624003719 active site 272624003720 citrylCoA binding site [chemical binding]; other site 272624003721 NADH binding [chemical binding]; other site 272624003722 cationic pore residues; other site 272624003723 oxalacetate/citrate binding site [chemical binding]; other site 272624003724 coenzyme A binding site [chemical binding]; other site 272624003725 catalytic triad [active] 272624003726 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 272624003727 DNA gyrase subunit A; Validated; Region: PRK05560 272624003728 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272624003729 CAP-like domain; other site 272624003730 active site 272624003731 primary dimer interface [polypeptide binding]; other site 272624003732 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272624003733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272624003734 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272624003735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272624003736 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272624003737 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272624003738 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 272624003739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624003740 catalytic residue [active] 272624003741 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272624003742 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272624003743 hinge; other site 272624003744 active site 272624003745 cytidylate kinase; Provisional; Region: cmk; PRK00023 272624003746 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272624003747 CMP-binding site; other site 272624003748 The sites determining sugar specificity; other site 272624003749 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272624003750 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 272624003751 RNA binding site [nucleotide binding]; other site 272624003752 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272624003753 RNA binding site [nucleotide binding]; other site 272624003754 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272624003755 RNA binding site [nucleotide binding]; other site 272624003756 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272624003757 RNA binding site [nucleotide binding]; other site 272624003758 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272624003759 RNA binding site [nucleotide binding]; other site 272624003760 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 272624003761 RNA binding site [nucleotide binding]; other site 272624003762 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 272624003763 tetratricopeptide repeat protein; Provisional; Region: PRK11788 272624003764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624003765 TPR motif; other site 272624003766 binding surface 272624003767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272624003768 binding surface 272624003769 TPR motif; other site 272624003770 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272624003771 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272624003772 inhibitor-cofactor binding pocket; inhibition site 272624003773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624003774 catalytic residue [active] 272624003775 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272624003776 active site 272624003777 dimer interface [polypeptide binding]; other site 272624003778 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272624003779 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272624003780 active site 272624003781 nucleophile elbow; other site 272624003782 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272624003783 classical (c) SDRs; Region: SDR_c; cd05233 272624003784 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 272624003785 NAD(P) binding site [chemical binding]; other site 272624003786 active site 272624003787 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 272624003788 Chorismate lyase; Region: Chor_lyase; cl01230 272624003789 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 272624003790 UbiA prenyltransferase family; Region: UbiA; pfam01040 272624003791 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 272624003792 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272624003793 FAD binding domain; Region: FAD_binding_4; pfam01565 272624003794 Berberine and berberine like; Region: BBE; pfam08031 272624003795 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272624003796 intersubunit interface [polypeptide binding]; other site 272624003797 active site 272624003798 catalytic residue [active] 272624003799 purine nucleoside phosphorylase; Provisional; Region: PRK08202 272624003800 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272624003801 active site 272624003802 catalytic motif [active] 272624003803 Zn binding site [ion binding]; other site 272624003804 two-component sensor protein; Provisional; Region: cpxA; PRK09470 272624003805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272624003806 dimerization interface [polypeptide binding]; other site 272624003807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624003808 dimer interface [polypeptide binding]; other site 272624003809 phosphorylation site [posttranslational modification] 272624003810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624003811 ATP binding site [chemical binding]; other site 272624003812 Mg2+ binding site [ion binding]; other site 272624003813 G-X-G motif; other site 272624003814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624003815 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272624003816 active site 272624003817 phosphorylation site [posttranslational modification] 272624003818 intermolecular recognition site; other site 272624003819 dimerization interface [polypeptide binding]; other site 272624003820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272624003821 DNA binding site [nucleotide binding] 272624003822 FOG: CBS domain [General function prediction only]; Region: COG0517 272624003823 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272624003824 Transporter associated domain; Region: CorC_HlyC; smart01091 272624003825 metal-binding heat shock protein; Provisional; Region: PRK00016 272624003826 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272624003827 PhoH-like protein; Region: PhoH; pfam02562 272624003828 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 272624003829 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272624003830 active site 272624003831 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272624003832 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 272624003833 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272624003834 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272624003835 active site 272624003836 HIGH motif; other site 272624003837 dimer interface [polypeptide binding]; other site 272624003838 KMSKS motif; other site 272624003839 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272624003840 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 272624003841 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272624003842 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272624003843 RNA binding surface [nucleotide binding]; other site 272624003844 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 272624003845 probable active site [active] 272624003846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272624003847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272624003848 DNA binding residues [nucleotide binding] 272624003849 dimerization interface [polypeptide binding]; other site 272624003850 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272624003851 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 272624003852 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 272624003853 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 272624003854 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 272624003855 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272624003856 substrate binding site [chemical binding]; other site 272624003857 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624003858 putative transporter; Provisional; Region: PRK10504 272624003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624003860 putative substrate translocation pore; other site 272624003861 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 272624003862 TRAM domain; Region: TRAM; pfam01938 272624003863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624003864 S-adenosylmethionine binding site [chemical binding]; other site 272624003865 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272624003866 HD domain; Region: HD_4; pfam13328 272624003867 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272624003868 synthetase active site [active] 272624003869 NTP binding site [chemical binding]; other site 272624003870 metal binding site [ion binding]; metal-binding site 272624003871 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272624003872 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272624003873 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 272624003874 aminotransferase; Validated; Region: PRK08175 272624003875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272624003876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624003877 homodimer interface [polypeptide binding]; other site 272624003878 catalytic residue [active] 272624003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 272624003880 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 272624003881 DHH family; Region: DHH; pfam01368 272624003882 DHHA1 domain; Region: DHHA1; pfam02272 272624003883 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 272624003884 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272624003885 FMN binding site [chemical binding]; other site 272624003886 active site 272624003887 catalytic residues [active] 272624003888 substrate binding site [chemical binding]; other site 272624003889 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104 272624003890 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272624003891 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272624003892 SEC-C motif; Region: SEC-C; pfam02810 272624003893 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 272624003894 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 272624003895 hypothetical protein; Provisional; Region: PRK05287 272624003896 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272624003897 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272624003898 CoA-binding site [chemical binding]; other site 272624003899 ATP-binding [chemical binding]; other site 272624003900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624003901 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 272624003902 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272624003903 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 272624003904 inhibitor-cofactor binding pocket; inhibition site 272624003905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624003906 catalytic residue [active] 272624003907 biotin synthase; Region: bioB; TIGR00433 272624003908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624003909 FeS/SAM binding site; other site 272624003910 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272624003911 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 272624003912 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272624003913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624003914 catalytic residue [active] 272624003915 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 272624003916 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272624003917 AAA domain; Region: AAA_26; pfam13500 272624003918 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 272624003919 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 272624003920 Uncharacterized conserved protein [Function unknown]; Region: COG2928 272624003921 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272624003922 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272624003923 dimer interface [polypeptide binding]; other site 272624003924 anticodon binding site; other site 272624003925 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272624003926 homodimer interface [polypeptide binding]; other site 272624003927 motif 1; other site 272624003928 active site 272624003929 motif 2; other site 272624003930 GAD domain; Region: GAD; pfam02938 272624003931 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272624003932 motif 3; other site 272624003933 CENP-A-nucleosome distal (CAD) centromere subunit; Region: CENP-Q; pfam13094 272624003934 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 272624003935 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272624003936 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272624003937 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 272624003938 putative DNA-binding cleft [nucleotide binding]; other site 272624003939 putative DNA clevage site; other site 272624003940 molecular lever; other site 272624003941 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272624003942 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272624003943 active site 272624003944 ATP binding site [chemical binding]; other site 272624003945 substrate binding site [chemical binding]; other site 272624003946 activation loop (A-loop); other site 272624003947 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272624003948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272624003949 putative DNA binding site [nucleotide binding]; other site 272624003950 putative Zn2+ binding site [ion binding]; other site 272624003951 AsnC family; Region: AsnC_trans_reg; pfam01037 272624003952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624003953 Coenzyme A binding pocket [chemical binding]; other site 272624003954 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272624003955 GAF domain; Region: GAF; pfam01590 272624003956 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272624003957 cyclase homology domain; Region: CHD; cd07302 272624003958 nucleotidyl binding site; other site 272624003959 metal binding site [ion binding]; metal-binding site 272624003960 dimer interface [polypeptide binding]; other site 272624003961 Phosphotransferase enzyme family; Region: APH; pfam01636 272624003962 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272624003963 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272624003964 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272624003965 putative active site pocket [active] 272624003966 dimerization interface [polypeptide binding]; other site 272624003967 putative catalytic residue [active] 272624003968 Dot/Icm substrate protein; Region: SidE; pfam12252 272624003969 aminopeptidase N; Provisional; Region: pepN; PRK14015 272624003970 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272624003971 Zn binding site [ion binding]; other site 272624003972 C factor cell-cell signaling protein; Provisional; Region: PRK09009 272624003973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624003974 NAD(P) binding site [chemical binding]; other site 272624003975 active site 272624003976 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272624003977 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272624003978 Coenzyme A binding pocket [chemical binding]; other site 272624003979 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 272624003980 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272624003981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624003982 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272624003983 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 272624003984 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272624003985 E3 interaction surface; other site 272624003986 lipoyl attachment site [posttranslational modification]; other site 272624003987 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272624003988 E3 interaction surface; other site 272624003989 lipoyl attachment site [posttranslational modification]; other site 272624003990 e3 binding domain; Region: E3_binding; pfam02817 272624003991 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272624003992 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 272624003993 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 272624003994 dimer interface [polypeptide binding]; other site 272624003995 TPP-binding site [chemical binding]; other site 272624003996 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 272624003997 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272624003998 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272624003999 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272624004000 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272624004001 Sporulation related domain; Region: SPOR; pfam05036 272624004002 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272624004003 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272624004004 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272624004005 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272624004006 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 272624004007 homodimer interface [polypeptide binding]; other site 272624004008 substrate-cofactor binding pocket; other site 272624004009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624004010 catalytic residue [active] 272624004011 lipoate-protein ligase B; Provisional; Region: PRK14342 272624004012 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272624004013 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272624004014 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272624004015 active site 272624004016 LssY C-terminus; Region: LssY_C; pfam14067 272624004017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 272624004018 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 272624004019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624004020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624004021 Walker A/P-loop; other site 272624004022 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 272624004023 ABC transporter; Region: ABC_tran; pfam00005 272624004024 Q-loop/lid; other site 272624004025 ABC transporter signature motif; other site 272624004026 Walker B; other site 272624004027 D-loop; other site 272624004028 H-loop/switch region; other site 272624004029 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272624004030 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624004031 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624004032 PAS domain; Region: PAS_9; pfam13426 272624004033 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624004034 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624004035 metal binding site [ion binding]; metal-binding site 272624004036 active site 272624004037 I-site; other site 272624004038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624004039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624004040 active site 272624004041 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 272624004042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624004043 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 272624004044 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 272624004045 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272624004046 Walker A motif; other site 272624004047 ATP binding site [chemical binding]; other site 272624004048 Walker B motif; other site 272624004049 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 272624004050 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272624004051 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272624004052 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272624004053 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272624004054 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272624004055 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272624004056 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272624004057 ligand binding site [chemical binding]; other site 272624004058 CAAX protease self-immunity; Region: Abi; pfam02517 272624004059 PEP synthetase regulatory protein; Provisional; Region: PRK05339 272624004060 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 272624004061 2-methylcitrate dehydratase; Region: prpD; TIGR02330 272624004062 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 272624004063 dimer interface [polypeptide binding]; other site 272624004064 Citrate synthase; Region: Citrate_synt; pfam00285 272624004065 active site 272624004066 citrylCoA binding site [chemical binding]; other site 272624004067 oxalacetate/citrate binding site [chemical binding]; other site 272624004068 coenzyme A binding site [chemical binding]; other site 272624004069 catalytic triad [active] 272624004070 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272624004071 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 272624004072 Uncharacterized conserved protein [Function unknown]; Region: COG4121 272624004073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272624004074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004075 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272624004076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004077 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272624004078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272624004079 inhibitor-cofactor binding pocket; inhibition site 272624004080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624004081 catalytic residue [active] 272624004082 Rubredoxin [Energy production and conversion]; Region: COG1773 272624004083 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272624004084 iron binding site [ion binding]; other site 272624004085 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 272624004086 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 272624004087 poly(A) polymerase; Region: pcnB; TIGR01942 272624004088 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272624004089 active site 272624004090 NTP binding site [chemical binding]; other site 272624004091 metal binding triad [ion binding]; metal-binding site 272624004092 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272624004093 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 272624004094 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272624004095 catalytic center binding site [active] 272624004096 ATP binding site [chemical binding]; other site 272624004097 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272624004098 Ligand Binding Site [chemical binding]; other site 272624004099 GTP-binding protein Der; Reviewed; Region: PRK00093 272624004100 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272624004101 G1 box; other site 272624004102 GTP/Mg2+ binding site [chemical binding]; other site 272624004103 Switch I region; other site 272624004104 G2 box; other site 272624004105 Switch II region; other site 272624004106 G3 box; other site 272624004107 G4 box; other site 272624004108 G5 box; other site 272624004109 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272624004110 G1 box; other site 272624004111 GTP/Mg2+ binding site [chemical binding]; other site 272624004112 Switch I region; other site 272624004113 G2 box; other site 272624004114 G3 box; other site 272624004115 Switch II region; other site 272624004116 G4 box; other site 272624004117 G5 box; other site 272624004118 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 272624004119 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 272624004120 Trp docking motif [polypeptide binding]; other site 272624004121 active site 272624004122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 272624004123 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 272624004124 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272624004125 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272624004126 dimer interface [polypeptide binding]; other site 272624004127 motif 1; other site 272624004128 active site 272624004129 motif 2; other site 272624004130 motif 3; other site 272624004131 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272624004132 anticodon binding site; other site 272624004133 Helix-turn-helix domain; Region: HTH_25; pfam13413 272624004134 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 272624004135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624004136 binding surface 272624004137 TPR motif; other site 272624004138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624004139 binding surface 272624004140 TPR motif; other site 272624004141 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 272624004142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624004143 FeS/SAM binding site; other site 272624004144 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272624004145 active site 272624004146 multimer interface [polypeptide binding]; other site 272624004147 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 272624004148 active site 272624004149 dinuclear metal binding site [ion binding]; other site 272624004150 dimerization interface [polypeptide binding]; other site 272624004151 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 272624004152 putative active site [active] 272624004153 putative metal binding site [ion binding]; other site 272624004154 septum formation inhibitor; Reviewed; Region: minC; PRK00339 272624004155 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 272624004156 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272624004157 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 272624004158 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 272624004159 acyl-activating enzyme (AAE) consensus motif; other site 272624004160 putative AMP binding site [chemical binding]; other site 272624004161 putative active site [active] 272624004162 putative CoA binding site [chemical binding]; other site 272624004163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272624004164 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272624004165 substrate binding pocket [chemical binding]; other site 272624004166 membrane-bound complex binding site; other site 272624004167 hinge residues; other site 272624004168 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 272624004169 putative active site [active] 272624004170 putative CoA binding site [chemical binding]; other site 272624004171 nudix motif; other site 272624004172 metal binding site [ion binding]; metal-binding site 272624004173 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 272624004174 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272624004175 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272624004176 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 272624004177 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272624004178 TPP-binding site [chemical binding]; other site 272624004179 tetramer interface [polypeptide binding]; other site 272624004180 heterodimer interface [polypeptide binding]; other site 272624004181 phosphorylation loop region [posttranslational modification] 272624004182 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272624004183 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272624004184 alpha subunit interface [polypeptide binding]; other site 272624004185 TPP binding site [chemical binding]; other site 272624004186 heterodimer interface [polypeptide binding]; other site 272624004187 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272624004188 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272624004189 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272624004190 E3 interaction surface; other site 272624004191 lipoyl attachment site [posttranslational modification]; other site 272624004192 e3 binding domain; Region: E3_binding; pfam02817 272624004193 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272624004194 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272624004195 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272624004196 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272624004197 mercuric reductase; Validated; Region: PRK06370 272624004198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624004199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272624004200 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434 272624004201 NMT1/THI5 like; Region: NMT1; pfam09084 272624004202 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 272624004203 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272624004204 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 272624004205 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272624004206 ThiS interaction site; other site 272624004207 putative active site [active] 272624004208 tetramer interface [polypeptide binding]; other site 272624004209 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 272624004210 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272624004211 dimer interface [polypeptide binding]; other site 272624004212 substrate binding site [chemical binding]; other site 272624004213 ATP binding site [chemical binding]; other site 272624004214 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272624004215 thiamine phosphate binding site [chemical binding]; other site 272624004216 active site 272624004217 pyrophosphate binding site [ion binding]; other site 272624004218 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 272624004219 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272624004220 ATP binding site [chemical binding]; other site 272624004221 substrate interface [chemical binding]; other site 272624004222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272624004223 active site residue [active] 272624004224 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 272624004225 active site 272624004226 Zn binding site [ion binding]; other site 272624004227 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 272624004228 TolB amino-terminal domain; Region: TolB_N; pfam04052 272624004229 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 272624004230 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272624004231 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272624004232 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272624004233 TolA protein; Region: tolA_full; TIGR02794 272624004234 TolA protein; Region: tolA_full; TIGR02794 272624004235 TonB C terminal; Region: TonB_2; pfam13103 272624004236 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272624004237 TolR protein; Region: tolR; TIGR02801 272624004238 TolQ protein; Region: tolQ; TIGR02796 272624004239 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272624004240 active site 272624004241 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272624004242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624004243 Walker A motif; other site 272624004244 ATP binding site [chemical binding]; other site 272624004245 Walker B motif; other site 272624004246 arginine finger; other site 272624004247 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272624004248 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 272624004249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272624004250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272624004251 DNA binding residues [nucleotide binding] 272624004252 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 272624004253 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272624004254 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272624004255 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 272624004256 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 272624004257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272624004258 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624004259 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 272624004260 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272624004261 NAD(P) binding site [chemical binding]; other site 272624004262 catalytic residues [active] 272624004263 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 272624004264 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 272624004265 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272624004266 putative catalytic residue [active] 272624004267 chromosome segregation protein; Provisional; Region: PRK03918 272624004268 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272624004269 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272624004270 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272624004271 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272624004272 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272624004273 Global regulator protein family; Region: CsrA; pfam02599 272624004274 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 272624004275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272624004276 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624004277 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 272624004278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272624004279 substrate binding site [chemical binding]; other site 272624004280 oxyanion hole (OAH) forming residues; other site 272624004281 trimer interface [polypeptide binding]; other site 272624004282 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272624004283 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272624004284 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 272624004285 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272624004286 dimer interface [polypeptide binding]; other site 272624004287 active site 272624004288 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624004289 Leucine-rich repeats; other site 272624004290 Substrate binding site [chemical binding]; other site 272624004291 RES domain; Region: RES; smart00953 272624004292 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 272624004293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624004294 S-adenosylmethionine binding site [chemical binding]; other site 272624004295 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 272624004296 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 272624004297 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 272624004298 nudix motif; other site 272624004299 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272624004300 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272624004301 putative catalytic cysteine [active] 272624004302 gamma-glutamyl kinase; Provisional; Region: PRK05429 272624004303 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272624004304 nucleotide binding site [chemical binding]; other site 272624004305 homotetrameric interface [polypeptide binding]; other site 272624004306 putative phosphate binding site [ion binding]; other site 272624004307 putative allosteric binding site; other site 272624004308 PUA domain; Region: PUA; pfam01472 272624004309 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272624004310 DNA binding residues [nucleotide binding] 272624004311 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272624004312 dimer interface [polypeptide binding]; other site 272624004313 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272624004314 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272624004315 DNA binding residues [nucleotide binding] 272624004316 dimer interface [polypeptide binding]; other site 272624004317 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 272624004318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624004319 Coenzyme A binding pocket [chemical binding]; other site 272624004320 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 272624004321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624004322 Coenzyme A binding pocket [chemical binding]; other site 272624004323 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624004324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272624004325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624004326 Walker A/P-loop; other site 272624004327 ATP binding site [chemical binding]; other site 272624004328 Q-loop/lid; other site 272624004329 ABC transporter signature motif; other site 272624004330 Walker B; other site 272624004331 D-loop; other site 272624004332 H-loop/switch region; other site 272624004333 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272624004334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624004335 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272624004336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624004337 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272624004338 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272624004339 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 272624004340 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 272624004341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272624004342 Penicillinase repressor; Region: Pencillinase_R; pfam03965 272624004343 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 272624004344 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 272624004345 Permutation of conserved domain; other site 272624004346 active site 272624004347 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272624004348 putative hydrolase; Provisional; Region: PRK10985 272624004349 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272624004350 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624004351 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272624004352 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 272624004353 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 272624004354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272624004355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272624004356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624004357 NAD(P) binding site [chemical binding]; other site 272624004358 active site 272624004359 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 272624004360 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272624004361 dimer interface [polypeptide binding]; other site 272624004362 active site 272624004363 CoA binding pocket [chemical binding]; other site 272624004364 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272624004365 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272624004366 putative ADP-binding pocket [chemical binding]; other site 272624004367 PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360 272624004368 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272624004369 FAD binding domain; Region: FAD_binding_4; pfam01565 272624004370 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272624004371 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 272624004372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272624004373 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 272624004374 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 272624004375 active site 272624004376 catalytic site [active] 272624004377 tetramer interface [polypeptide binding]; other site 272624004378 enterobactin exporter EntS; Provisional; Region: PRK10489 272624004379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004380 putative substrate translocation pore; other site 272624004381 Predicted membrane protein [Function unknown]; Region: COG2119 272624004382 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 272624004383 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 272624004384 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 272624004385 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272624004386 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272624004387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272624004388 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 272624004389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624004390 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272624004391 threonine synthase; Validated; Region: PRK09225 272624004392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624004393 catalytic residue [active] 272624004394 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272624004395 YceI-like domain; Region: YceI; pfam04264 272624004396 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 272624004397 YceI-like domain; Region: YceI; smart00867 272624004398 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 272624004399 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272624004400 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 272624004401 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272624004402 PYR/PP interface [polypeptide binding]; other site 272624004403 dimer interface [polypeptide binding]; other site 272624004404 TPP binding site [chemical binding]; other site 272624004405 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272624004406 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 272624004407 TPP-binding site; other site 272624004408 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272624004409 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272624004410 substrate binding site [chemical binding]; other site 272624004411 ATP binding site [chemical binding]; other site 272624004412 KduI/IolB family; Region: KduI; pfam04962 272624004413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272624004414 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272624004415 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272624004416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004417 putative substrate translocation pore; other site 272624004418 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272624004419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004420 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 272624004421 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272624004422 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 272624004423 active site 272624004424 Zn binding site [ion binding]; other site 272624004425 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272624004426 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 272624004427 Amidinotransferase; Region: Amidinotransf; cl12043 272624004428 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 272624004429 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624004430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 272624004431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624004432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004433 putative substrate translocation pore; other site 272624004434 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 272624004435 Transglycosylase; Region: Transgly; pfam00912 272624004436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272624004437 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 272624004438 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 272624004439 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 272624004440 MG2 domain; Region: A2M_N; pfam01835 272624004441 Alpha-2-macroglobulin family; Region: A2M; pfam00207 272624004442 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 272624004443 surface patch; other site 272624004444 thioester region; other site 272624004445 specificity defining residues; other site 272624004446 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 272624004447 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272624004448 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272624004449 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 272624004450 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272624004451 active site 272624004452 catalytic site [active] 272624004453 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 272624004454 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272624004455 active site 272624004456 substrate binding site [chemical binding]; other site 272624004457 cosubstrate binding site; other site 272624004458 catalytic site [active] 272624004459 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272624004460 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272624004461 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272624004462 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272624004463 amidophosphoribosyltransferase; Provisional; Region: PRK09246 272624004464 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272624004465 active site 272624004466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624004467 active site 272624004468 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 272624004469 ATP binding site [chemical binding]; other site 272624004470 active site 272624004471 substrate binding site [chemical binding]; other site 272624004472 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 272624004473 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272624004474 putative active site [active] 272624004475 catalytic triad [active] 272624004476 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272624004477 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272624004478 dimerization interface [polypeptide binding]; other site 272624004479 putative ATP binding site [chemical binding]; other site 272624004480 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272624004481 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272624004482 dimerization interface [polypeptide binding]; other site 272624004483 ATP binding site [chemical binding]; other site 272624004484 Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824 272624004485 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272624004486 dimerization interface [polypeptide binding]; other site 272624004487 ATP binding site [chemical binding]; other site 272624004488 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272624004489 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 272624004490 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272624004491 DsbD alpha interface [polypeptide binding]; other site 272624004492 catalytic residues [active] 272624004493 short chain dehydrogenase; Provisional; Region: PRK05993 272624004494 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272624004495 NADP binding site [chemical binding]; other site 272624004496 active site 272624004497 steroid binding site; other site 272624004498 D123; Region: D123; pfam07065 272624004499 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272624004500 aconitate hydratase; Validated; Region: PRK09277 272624004501 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272624004502 substrate binding site [chemical binding]; other site 272624004503 ligand binding site [chemical binding]; other site 272624004504 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272624004505 substrate binding site [chemical binding]; other site 272624004506 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 272624004507 DDE superfamily endonuclease; Region: DDE_3; pfam13358 272624004508 Winged helix-turn helix; Region: HTH_33; pfam13592 272624004509 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 272624004510 Proline dehydrogenase; Region: Pro_dh; pfam01619 272624004511 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 272624004512 Glutamate binding site [chemical binding]; other site 272624004513 NAD binding site [chemical binding]; other site 272624004514 catalytic residues [active] 272624004515 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 272624004516 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 272624004517 ProQ/FINO family; Region: ProQ; pfam04352 272624004518 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 272624004519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624004520 S-adenosylmethionine binding site [chemical binding]; other site 272624004521 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 272624004522 ligand binding site [chemical binding]; other site 272624004523 active site 272624004524 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 272624004525 cell division protein MukB; Provisional; Region: mukB; PRK04863 272624004526 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272624004527 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272624004528 active site 272624004529 DNA binding site [nucleotide binding] 272624004530 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272624004531 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272624004532 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272624004533 Catalytic site [active] 272624004534 hypothetical protein; Provisional; Region: PRK07338 272624004535 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 272624004536 metal binding site [ion binding]; metal-binding site 272624004537 dimer interface [polypeptide binding]; other site 272624004538 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 272624004539 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 272624004540 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 272624004541 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 272624004542 NAD(P) binding site [chemical binding]; other site 272624004543 catalytic residues [active] 272624004544 succinylarginine dihydrolase; Provisional; Region: PRK13281 272624004545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624004546 Cytochrome c; Region: Cytochrom_C; cl11414 272624004547 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272624004548 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272624004549 hinge region; other site 272624004550 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272624004551 putative nucleotide binding site [chemical binding]; other site 272624004552 uridine monophosphate binding site [chemical binding]; other site 272624004553 homohexameric interface [polypeptide binding]; other site 272624004554 elongation factor Ts; Provisional; Region: tsf; PRK09377 272624004555 UBA/TS-N domain; Region: UBA; pfam00627 272624004556 Elongation factor TS; Region: EF_TS; pfam00889 272624004557 Elongation factor TS; Region: EF_TS; pfam00889 272624004558 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272624004559 rRNA interaction site [nucleotide binding]; other site 272624004560 S8 interaction site; other site 272624004561 putative laminin-1 binding site; other site 272624004562 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 272624004563 dimer interface [polypeptide binding]; other site 272624004564 SET domain; Region: SET; pfam00856 272624004565 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624004566 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624004567 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272624004568 active site 272624004569 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 272624004570 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272624004571 metal binding triad; other site 272624004572 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272624004573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272624004574 Zn2+ binding site [ion binding]; other site 272624004575 Mg2+ binding site [ion binding]; other site 272624004576 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 272624004577 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 272624004578 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272624004579 nucleoside/Zn binding site; other site 272624004580 dimer interface [polypeptide binding]; other site 272624004581 catalytic motif [active] 272624004582 GMP synthase; Reviewed; Region: guaA; PRK00074 272624004583 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272624004584 AMP/PPi binding site [chemical binding]; other site 272624004585 candidate oxyanion hole; other site 272624004586 catalytic triad [active] 272624004587 potential glutamine specificity residues [chemical binding]; other site 272624004588 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272624004589 ATP Binding subdomain [chemical binding]; other site 272624004590 Ligand Binding sites [chemical binding]; other site 272624004591 Dimerization subdomain; other site 272624004592 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272624004593 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272624004594 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272624004595 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272624004596 active site 272624004597 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 272624004598 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272624004599 Switch I; other site 272624004600 Switch II; other site 272624004601 similar to cell division inhibitor MinE, pseudogene 272624004602 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 272624004603 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 272624004604 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272624004605 active site 272624004606 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 272624004607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624004608 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272624004609 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272624004610 Walker A/P-loop; other site 272624004611 ATP binding site [chemical binding]; other site 272624004612 Q-loop/lid; other site 272624004613 ABC transporter signature motif; other site 272624004614 Walker B; other site 272624004615 D-loop; other site 272624004616 H-loop/switch region; other site 272624004617 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272624004618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624004619 dimer interface [polypeptide binding]; other site 272624004620 conserved gate region; other site 272624004621 putative PBP binding loops; other site 272624004622 ABC-ATPase subunit interface; other site 272624004623 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272624004624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624004625 dimer interface [polypeptide binding]; other site 272624004626 conserved gate region; other site 272624004627 putative PBP binding loops; other site 272624004628 ABC-ATPase subunit interface; other site 272624004629 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 272624004630 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 272624004631 NAD(P) binding site [chemical binding]; other site 272624004632 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272624004633 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272624004634 Cl- selectivity filter; other site 272624004635 Cl- binding residues [ion binding]; other site 272624004636 pore gating glutamate residue; other site 272624004637 dimer interface [polypeptide binding]; other site 272624004638 H+/Cl- coupling transport residue; other site 272624004639 anthranilate synthase; Provisional; Region: PRK13566 272624004640 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272624004641 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272624004642 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272624004643 glutamine binding [chemical binding]; other site 272624004644 catalytic triad [active] 272624004645 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272624004646 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272624004647 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272624004648 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272624004649 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272624004650 GatB domain; Region: GatB_Yqey; smart00845 272624004651 Autotransporter beta-domain; Region: Autotransporter; smart00869 272624004652 CHASE2 domain; Region: CHASE2; pfam05226 272624004653 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 272624004654 cyclase homology domain; Region: CHD; cd07302 272624004655 nucleotidyl binding site; other site 272624004656 metal binding site [ion binding]; metal-binding site 272624004657 dimer interface [polypeptide binding]; other site 272624004658 FecR protein; Region: FecR; pfam04773 272624004659 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272624004660 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272624004661 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 272624004662 trimerization site [polypeptide binding]; other site 272624004663 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272624004664 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272624004665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624004666 catalytic residue [active] 272624004667 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 272624004668 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 272624004669 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272624004670 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272624004671 active site 272624004672 dimerization interface [polypeptide binding]; other site 272624004673 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272624004674 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 272624004675 tandem repeat interface [polypeptide binding]; other site 272624004676 oligomer interface [polypeptide binding]; other site 272624004677 active site residues [active] 272624004678 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 272624004679 Clp amino terminal domain; Region: Clp_N; pfam02861 272624004680 Clp amino terminal domain; Region: Clp_N; pfam02861 272624004681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624004682 Walker A motif; other site 272624004683 ATP binding site [chemical binding]; other site 272624004684 Walker B motif; other site 272624004685 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 272624004686 arginine finger; other site 272624004687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624004688 Walker A motif; other site 272624004689 ATP binding site [chemical binding]; other site 272624004690 Walker B motif; other site 272624004691 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272624004692 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 272624004693 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272624004694 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272624004695 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272624004696 TIGR02099 family protein; Region: TIGR02099 272624004697 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272624004698 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 272624004699 Flagellar FliJ protein; Region: FliJ; pfam02050 272624004700 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 272624004701 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272624004702 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 272624004703 Walker A motif/ATP binding site; other site 272624004704 Walker B motif; other site 272624004705 Flagellar assembly protein FliH; Region: FliH; pfam02108 272624004706 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 272624004707 FliG C-terminal domain; Region: FliG_C; pfam01706 272624004708 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 272624004709 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 272624004710 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 272624004711 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 272624004712 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272624004713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624004714 active site 272624004715 phosphorylation site [posttranslational modification] 272624004716 intermolecular recognition site; other site 272624004717 dimerization interface [polypeptide binding]; other site 272624004718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624004719 Walker A motif; other site 272624004720 ATP binding site [chemical binding]; other site 272624004721 Walker B motif; other site 272624004722 arginine finger; other site 272624004723 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272624004724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272624004725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624004726 putative active site [active] 272624004727 heme pocket [chemical binding]; other site 272624004728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624004729 dimer interface [polypeptide binding]; other site 272624004730 phosphorylation site [posttranslational modification] 272624004731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624004732 ATP binding site [chemical binding]; other site 272624004733 G-X-G motif; other site 272624004734 recombination factor protein RarA; Reviewed; Region: PRK13342 272624004735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624004736 Walker A motif; other site 272624004737 ATP binding site [chemical binding]; other site 272624004738 Walker B motif; other site 272624004739 arginine finger; other site 272624004740 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272624004741 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 272624004742 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 272624004743 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272624004744 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272624004745 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272624004746 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272624004747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272624004748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624004749 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 272624004750 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272624004751 active site residue [active] 272624004752 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272624004753 rRNA binding site [nucleotide binding]; other site 272624004754 predicted 30S ribosome binding site; other site 272624004755 peptidase PmbA; Provisional; Region: PRK11040 272624004756 Predicted periplasmic protein [Function unknown]; Region: COG3698 272624004757 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272624004758 Cupin-like domain; Region: Cupin_8; pfam13621 272624004759 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 272624004760 ATP cone domain; Region: ATP-cone; pfam03477 272624004761 ATP cone domain; Region: ATP-cone; pfam03477 272624004762 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272624004763 active site 272624004764 dimer interface [polypeptide binding]; other site 272624004765 catalytic residues [active] 272624004766 effector binding site; other site 272624004767 R2 peptide binding site; other site 272624004768 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272624004769 dimer interface [polypeptide binding]; other site 272624004770 putative radical transfer pathway; other site 272624004771 diiron center [ion binding]; other site 272624004772 tyrosyl radical; other site 272624004773 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272624004774 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272624004775 dimer interface [polypeptide binding]; other site 272624004776 putative anticodon binding site; other site 272624004777 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272624004778 motif 1; other site 272624004779 active site 272624004780 motif 2; other site 272624004781 motif 3; other site 272624004782 peptide chain release factor 2; Validated; Region: prfB; PRK00578 272624004783 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272624004784 RF-1 domain; Region: RF-1; pfam00472 272624004785 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 272624004786 flagellar motor protein MotD; Reviewed; Region: PRK09038 272624004787 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272624004788 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272624004789 ligand binding site [chemical binding]; other site 272624004790 flagellar motor protein; Reviewed; Region: motC; PRK09109 272624004791 flagellar motor protein MotA; Validated; Region: PRK08124 272624004792 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 272624004793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272624004794 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272624004795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272624004796 DNA binding residues [nucleotide binding] 272624004797 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 272624004798 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 272624004799 P-loop; other site 272624004800 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 272624004801 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 272624004802 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272624004803 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 272624004804 FHIPEP family; Region: FHIPEP; pfam00771 272624004805 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 272624004806 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272624004807 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 272624004808 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 272624004809 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 272624004810 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 272624004811 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 272624004812 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 272624004813 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 272624004814 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272624004815 FAD binding domain; Region: FAD_binding_4; pfam01565 272624004816 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272624004817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624004818 NAD(P) binding site [chemical binding]; other site 272624004819 active site 272624004820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624004821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624004822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272624004823 dimerization interface [polypeptide binding]; other site 272624004824 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 272624004825 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 272624004826 GTPase interaction site; other site 272624004827 catalytic residue [active] 272624004828 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272624004829 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272624004830 motif 1; other site 272624004831 active site 272624004832 motif 2; other site 272624004833 motif 3; other site 272624004834 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272624004835 recombination regulator RecX; Reviewed; Region: recX; PRK00117 272624004836 recombinase A; Provisional; Region: recA; PRK09354 272624004837 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272624004838 hexamer interface [polypeptide binding]; other site 272624004839 Walker A motif; other site 272624004840 ATP binding site [chemical binding]; other site 272624004841 Walker B motif; other site 272624004842 Competence-damaged protein; Region: CinA; pfam02464 272624004843 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272624004844 MutS domain I; Region: MutS_I; pfam01624 272624004845 MutS domain II; Region: MutS_II; pfam05188 272624004846 MutS domain III; Region: MutS_III; pfam05192 272624004847 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272624004848 Walker A/P-loop; other site 272624004849 ATP binding site [chemical binding]; other site 272624004850 Q-loop/lid; other site 272624004851 ABC transporter signature motif; other site 272624004852 Walker B; other site 272624004853 D-loop; other site 272624004854 H-loop/switch region; other site 272624004855 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 272624004856 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272624004857 Surface antigen; Region: Bac_surface_Ag; pfam01103 272624004858 Family of unknown function (DUF490); Region: DUF490; pfam04357 272624004859 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272624004860 dimer interface [polypeptide binding]; other site 272624004861 active site 272624004862 Schiff base residues; other site 272624004863 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 272624004864 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 272624004865 AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259 272624004866 putative catalytic residues [active] 272624004867 putative nucleotide binding site [chemical binding]; other site 272624004868 putative aspartate binding site [chemical binding]; other site 272624004869 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 272624004870 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920 272624004871 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840 272624004872 active site 272624004873 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272624004874 substrate binding site [chemical binding]; other site 272624004875 catalytic residues [active] 272624004876 dimer interface [polypeptide binding]; other site 272624004877 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 272624004878 Part of AAA domain; Region: AAA_19; pfam13245 272624004879 Family description; Region: UvrD_C_2; pfam13538 272624004880 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272624004881 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272624004882 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 272624004883 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272624004884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624004885 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272624004886 dimerization interface [polypeptide binding]; other site 272624004887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624004888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624004889 putative substrate translocation pore; other site 272624004890 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 272624004891 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 272624004892 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 272624004893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624004894 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272624004895 Walker A/P-loop; other site 272624004896 ATP binding site [chemical binding]; other site 272624004897 Q-loop/lid; other site 272624004898 ABC transporter signature motif; other site 272624004899 Walker B; other site 272624004900 D-loop; other site 272624004901 H-loop/switch region; other site 272624004902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272624004903 Coenzyme A binding pocket [chemical binding]; other site 272624004904 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272624004905 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272624004906 quinone interaction residues [chemical binding]; other site 272624004907 active site 272624004908 catalytic residues [active] 272624004909 FMN binding site [chemical binding]; other site 272624004910 substrate binding site [chemical binding]; other site 272624004911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624004912 isovaleryl-CoA dehydrogenase; Region: PLN02519 272624004913 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 272624004914 substrate binding site [chemical binding]; other site 272624004915 FAD binding site [chemical binding]; other site 272624004916 catalytic base [active] 272624004917 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 272624004918 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272624004919 dimer interface [polypeptide binding]; other site 272624004920 active site 272624004921 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 272624004922 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 272624004923 enoyl-CoA hydratase; Provisional; Region: PRK05995 272624004924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272624004925 substrate binding site [chemical binding]; other site 272624004926 oxyanion hole (OAH) forming residues; other site 272624004927 trimer interface [polypeptide binding]; other site 272624004928 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 272624004929 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 272624004930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272624004931 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272624004932 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272624004933 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272624004934 carboxyltransferase (CT) interaction site; other site 272624004935 biotinylation site [posttranslational modification]; other site 272624004936 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 272624004937 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 272624004938 active site 272624004939 catalytic residues [active] 272624004940 metal binding site [ion binding]; metal-binding site 272624004941 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 272624004942 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 272624004943 acyl-activating enzyme (AAE) consensus motif; other site 272624004944 putative AMP binding site [chemical binding]; other site 272624004945 putative active site [active] 272624004946 putative CoA binding site [chemical binding]; other site 272624004947 VirK protein; Region: VirK; pfam06903 272624004948 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272624004949 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272624004950 Walker A/P-loop; other site 272624004951 ATP binding site [chemical binding]; other site 272624004952 Q-loop/lid; other site 272624004953 ABC transporter signature motif; other site 272624004954 Walker B; other site 272624004955 D-loop; other site 272624004956 H-loop/switch region; other site 272624004957 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 272624004958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272624004959 dimer interface [polypeptide binding]; other site 272624004960 conserved gate region; other site 272624004961 ABC-ATPase subunit interface; other site 272624004962 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272624004963 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272624004964 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 272624004965 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 272624004966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624004967 active site 272624004968 motif I; other site 272624004969 motif II; other site 272624004970 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272624004971 DALR anticodon binding domain; Region: DALR_1; pfam05746 272624004972 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272624004973 dimer interface [polypeptide binding]; other site 272624004974 motif 1; other site 272624004975 active site 272624004976 motif 2; other site 272624004977 motif 3; other site 272624004978 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272624004979 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272624004980 catalytic residues [active] 272624004981 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 272624004982 Part of AAA domain; Region: AAA_19; pfam13245 272624004983 Family description; Region: UvrD_C_2; pfam13538 272624004984 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 272624004985 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272624004986 putative active site [active] 272624004987 dimerization interface [polypeptide binding]; other site 272624004988 putative tRNAtyr binding site [nucleotide binding]; other site 272624004989 VacJ like lipoprotein; Region: VacJ; cl01073 272624004990 glutathione synthetase; Provisional; Region: PRK05246 272624004991 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 272624004992 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 272624004993 Glutamate-cysteine ligase; Region: GshA; pfam08886 272624004994 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 272624004995 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272624004996 EamA-like transporter family; Region: EamA; pfam00892 272624004997 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272624004998 active site residue [active] 272624004999 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 272624005000 PglZ domain; Region: PglZ; pfam08665 272624005001 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 272624005002 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272624005003 Sugar specificity; other site 272624005004 Pyrimidine base specificity; other site 272624005005 ATP-binding site [chemical binding]; other site 272624005006 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 272624005007 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272624005008 NAD binding site [chemical binding]; other site 272624005009 homotetramer interface [polypeptide binding]; other site 272624005010 homodimer interface [polypeptide binding]; other site 272624005011 substrate binding site [chemical binding]; other site 272624005012 active site 272624005013 periplasmic folding chaperone; Provisional; Region: PRK10788 272624005014 SurA N-terminal domain; Region: SurA_N_3; cl07813 272624005015 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272624005016 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272624005017 IHF dimer interface [polypeptide binding]; other site 272624005018 IHF - DNA interface [nucleotide binding]; other site 272624005019 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272624005020 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272624005021 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272624005022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624005023 Walker A motif; other site 272624005024 ATP binding site [chemical binding]; other site 272624005025 Walker B motif; other site 272624005026 arginine finger; other site 272624005027 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272624005028 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272624005029 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272624005030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624005031 Walker A motif; other site 272624005032 ATP binding site [chemical binding]; other site 272624005033 Walker B motif; other site 272624005034 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272624005035 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272624005036 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272624005037 oligomer interface [polypeptide binding]; other site 272624005038 active site residues [active] 272624005039 trigger factor; Provisional; Region: tig; PRK01490 272624005040 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272624005041 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272624005042 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 272624005043 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 272624005044 Int/Topo IB signature motif; other site 272624005045 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 272624005046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624005047 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624005048 ABC transporter; Region: ABC_tran_2; pfam12848 272624005049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624005050 ribonuclease III; Reviewed; Region: rnc; PRK00102 272624005051 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272624005052 dimerization interface [polypeptide binding]; other site 272624005053 active site 272624005054 metal binding site [ion binding]; metal-binding site 272624005055 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272624005056 dsRNA binding site [nucleotide binding]; other site 272624005057 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 272624005058 signal peptidase I; Provisional; Region: PRK10861 272624005059 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272624005060 Catalytic site [active] 272624005061 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272624005062 GTP-binding protein LepA; Provisional; Region: PRK05433 272624005063 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272624005064 G1 box; other site 272624005065 putative GEF interaction site [polypeptide binding]; other site 272624005066 GTP/Mg2+ binding site [chemical binding]; other site 272624005067 Switch I region; other site 272624005068 G2 box; other site 272624005069 G3 box; other site 272624005070 Switch II region; other site 272624005071 G4 box; other site 272624005072 G5 box; other site 272624005073 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272624005074 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272624005075 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272624005076 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272624005077 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272624005078 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272624005079 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 272624005080 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 272624005081 GspL periplasmic domain; Region: GspL_C; cl14909 272624005082 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 272624005083 Sporulation related domain; Region: SPOR; cl10051 272624005084 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 272624005085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272624005086 Zn2+ binding site [ion binding]; other site 272624005087 Mg2+ binding site [ion binding]; other site 272624005088 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272624005089 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272624005090 dimer interface [polypeptide binding]; other site 272624005091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272624005092 active site 272624005093 metal binding site [ion binding]; metal-binding site 272624005094 glutathione binding site [chemical binding]; other site 272624005095 hypothetical protein; Provisional; Region: PRK05208 272624005096 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 272624005097 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 272624005098 acylphosphatase; Provisional; Region: PRK14451 272624005099 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272624005100 putative active site [active] 272624005101 catalytic site [active] 272624005102 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272624005103 PLD-like domain; Region: PLDc_2; pfam13091 272624005104 putative active site [active] 272624005105 catalytic site [active] 272624005106 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272624005107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272624005108 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624005109 Leucine-rich repeats; other site 272624005110 Substrate binding site [chemical binding]; other site 272624005111 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624005112 Leucine-rich repeats; other site 272624005113 Leucine rich repeat; Region: LRR_8; pfam13855 272624005114 Substrate binding site [chemical binding]; other site 272624005115 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 272624005116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624005117 D-galactonate transporter; Region: 2A0114; TIGR00893 272624005118 putative substrate translocation pore; other site 272624005119 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272624005120 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 272624005121 putative ion selectivity filter; other site 272624005122 putative pore gating glutamate residue; other site 272624005123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 272624005124 SEC-C motif; Region: SEC-C; pfam02810 272624005125 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 272624005126 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272624005127 TrkA-N domain; Region: TrkA_N; pfam02254 272624005128 MoxR-like ATPases [General function prediction only]; Region: COG0714 272624005129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624005130 Walker A motif; other site 272624005131 ATP binding site [chemical binding]; other site 272624005132 Walker B motif; other site 272624005133 arginine finger; other site 272624005134 Protein of unknown function DUF58; Region: DUF58; pfam01882 272624005135 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 272624005136 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272624005137 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272624005138 Uncharacterized conserved protein [Function unknown]; Region: COG2850 272624005139 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624005140 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272624005141 EamA-like transporter family; Region: EamA; pfam00892 272624005142 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272624005143 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272624005144 nucleotide binding site [chemical binding]; other site 272624005145 Protein of unknown function, DUF462; Region: DUF462; pfam04315 272624005146 glutathionine S-transferase; Provisional; Region: PRK10542 272624005147 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 272624005148 C-terminal domain interface [polypeptide binding]; other site 272624005149 GSH binding site (G-site) [chemical binding]; other site 272624005150 dimer interface [polypeptide binding]; other site 272624005151 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 272624005152 N-terminal domain interface [polypeptide binding]; other site 272624005153 dimer interface [polypeptide binding]; other site 272624005154 substrate binding pocket (H-site) [chemical binding]; other site 272624005155 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272624005156 Beta-lactamase; Region: Beta-lactamase; pfam00144 272624005157 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272624005158 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272624005159 HIGH motif; other site 272624005160 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272624005161 active site 272624005162 KMSKS motif; other site 272624005163 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 272624005164 HAMP domain; Region: HAMP; pfam00672 272624005165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624005166 dimer interface [polypeptide binding]; other site 272624005167 phosphorylation site [posttranslational modification] 272624005168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624005169 ATP binding site [chemical binding]; other site 272624005170 Mg2+ binding site [ion binding]; other site 272624005171 G-X-G motif; other site 272624005172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624005173 active site 272624005174 phosphorylation site [posttranslational modification] 272624005175 intermolecular recognition site; other site 272624005176 dimerization interface [polypeptide binding]; other site 272624005177 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272624005178 putative binding surface; other site 272624005179 active site 272624005180 6-phosphofructokinase; Provisional; Region: PRK14072 272624005181 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 272624005182 active site 272624005183 ADP/pyrophosphate binding site [chemical binding]; other site 272624005184 dimerization interface [polypeptide binding]; other site 272624005185 allosteric effector site; other site 272624005186 fructose-1,6-bisphosphate binding site; other site 272624005187 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 272624005188 Pilin (bacterial filament); Region: Pilin; pfam00114 272624005189 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 272624005190 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 272624005191 Pilin (bacterial filament); Region: Pilin; pfam00114 272624005192 BolA-like protein; Region: BolA; cl00386 272624005193 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 272624005194 Calcium-activated chloride channel; Region: Anoctamin; pfam04547 272624005195 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 272624005196 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 272624005197 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 272624005198 Ligand binding site; other site 272624005199 oligomer interface; other site 272624005200 Uncharacterized conserved protein [Function unknown]; Region: COG2835 272624005201 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272624005202 Glycoprotease family; Region: Peptidase_M22; pfam00814 272624005203 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272624005204 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272624005205 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272624005206 Ferredoxin [Energy production and conversion]; Region: COG1146 272624005207 4Fe-4S binding domain; Region: Fer4; cl02805 272624005208 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 272624005209 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272624005210 PilZ domain; Region: PilZ; pfam07238 272624005211 oxidative damage protection protein; Provisional; Region: PRK05408 272624005212 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 272624005213 HipA N-terminal domain; Region: Couple_hipA; pfam13657 272624005214 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272624005215 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272624005216 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272624005217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624005218 non-specific DNA binding site [nucleotide binding]; other site 272624005219 salt bridge; other site 272624005220 sequence-specific DNA binding site [nucleotide binding]; other site 272624005221 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 272624005222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624005223 S-adenosylmethionine binding site [chemical binding]; other site 272624005224 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 272624005225 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 272624005226 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 272624005227 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 272624005228 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272624005229 active site 272624005230 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272624005231 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 272624005232 acyl-activating enzyme (AAE) consensus motif; other site 272624005233 AMP binding site [chemical binding]; other site 272624005234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272624005235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272624005236 active site 272624005237 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 272624005238 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272624005239 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272624005240 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272624005241 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272624005242 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272624005243 active site 272624005244 nucleophile elbow; other site 272624005245 Patatin phospholipase; Region: DUF3734; pfam12536 272624005246 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 272624005247 PAS fold; Region: PAS_4; pfam08448 272624005248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272624005249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272624005250 DNA binding residues [nucleotide binding] 272624005251 dimerization interface [polypeptide binding]; other site 272624005252 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624005253 Leucine-rich repeats; other site 272624005254 Substrate binding site [chemical binding]; other site 272624005255 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171 272624005256 active site/putative ARF binding site [active] 272624005257 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272624005258 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272624005259 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272624005260 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272624005261 active site 272624005262 metal binding site [ion binding]; metal-binding site 272624005263 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272624005264 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272624005265 active site 272624005266 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624005267 Leucine-rich repeats; other site 272624005268 Substrate binding site [chemical binding]; other site 272624005269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624005270 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 272624005271 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 272624005272 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 272624005273 active site 272624005274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272624005275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272624005276 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272624005277 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 272624005278 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272624005279 C-terminal domain interface [polypeptide binding]; other site 272624005280 GSH binding site (G-site) [chemical binding]; other site 272624005281 dimer interface [polypeptide binding]; other site 272624005282 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 272624005283 N-terminal domain interface [polypeptide binding]; other site 272624005284 dimer interface [polypeptide binding]; other site 272624005285 substrate binding pocket (H-site) [chemical binding]; other site 272624005286 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 272624005287 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 272624005288 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272624005289 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272624005290 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272624005291 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272624005292 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 272624005293 conserved cys residue [active] 272624005294 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 272624005295 TPR repeat; Region: TPR_11; pfam13414 272624005296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624005297 binding surface 272624005298 TPR motif; other site 272624005299 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272624005300 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272624005301 active site 272624005302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272624005303 Toprim domain; Region: Toprim_3; pfam13362 272624005304 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272624005305 catalytic core [active] 272624005306 RibD C-terminal domain; Region: RibD_C; cl17279 272624005307 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272624005308 MAPEG family; Region: MAPEG; cl09190 272624005309 YhhN-like protein; Region: YhhN; pfam07947 272624005310 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 272624005311 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 272624005312 NodB motif; other site 272624005313 putative active site [active] 272624005314 putative catalytic site [active] 272624005315 putative Zn binding site [ion binding]; other site 272624005316 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 272624005317 MltA specific insert domain; Region: MltA; pfam03562 272624005318 3D domain; Region: 3D; pfam06725 272624005319 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 272624005320 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 272624005321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272624005322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624005323 homodimer interface [polypeptide binding]; other site 272624005324 catalytic residue [active] 272624005325 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 272624005326 aromatic arch; other site 272624005327 DCoH dimer interaction site [polypeptide binding]; other site 272624005328 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 272624005329 DCoH tetramer interaction site [polypeptide binding]; other site 272624005330 substrate binding site [chemical binding]; other site 272624005331 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272624005332 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272624005333 Protein export membrane protein; Region: SecD_SecF; pfam02355 272624005334 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 272624005335 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272624005336 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272624005337 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 272624005338 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 272624005339 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 272624005340 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272624005341 ABC transporter ATPase component; Reviewed; Region: PRK11147 272624005342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624005343 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624005344 ABC transporter; Region: ABC_tran_2; pfam12848 272624005345 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272624005346 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 272624005347 catalytic motif [active] 272624005348 Catalytic residue [active] 272624005349 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272624005350 homotrimer interaction site [polypeptide binding]; other site 272624005351 putative active site [active] 272624005352 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 272624005353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272624005354 Zn2+ binding site [ion binding]; other site 272624005355 Mg2+ binding site [ion binding]; other site 272624005356 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272624005357 synthetase active site [active] 272624005358 NTP binding site [chemical binding]; other site 272624005359 metal binding site [ion binding]; metal-binding site 272624005360 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272624005361 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272624005362 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272624005363 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272624005364 catalytic site [active] 272624005365 G-X2-G-X-G-K; other site 272624005366 hypothetical protein; Provisional; Region: PRK11820 272624005367 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272624005368 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272624005369 ribonuclease PH; Reviewed; Region: rph; PRK00173 272624005370 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272624005371 hexamer interface [polypeptide binding]; other site 272624005372 active site 272624005373 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 272624005374 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 272624005375 Walker A motif; other site 272624005376 ATP binding site [chemical binding]; other site 272624005377 Walker B motif; other site 272624005378 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 272624005379 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272624005380 catalytic residue [active] 272624005381 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 272624005382 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272624005383 YGGT family; Region: YGGT; pfam02325 272624005384 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 272624005385 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 272624005386 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 272624005387 active site 272624005388 catalytic residues [active] 272624005389 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 272624005390 Helix-turn-helix domain; Region: HTH_18; pfam12833 272624005391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272624005392 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 272624005393 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 272624005394 homotetramer interface [polypeptide binding]; other site 272624005395 ligand binding site [chemical binding]; other site 272624005396 catalytic site [active] 272624005397 NAD binding site [chemical binding]; other site 272624005398 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272624005399 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272624005400 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272624005401 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272624005402 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272624005403 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272624005404 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272624005405 catalytic site [active] 272624005406 subunit interface [polypeptide binding]; other site 272624005407 chaperone protein DnaJ; Provisional; Region: PRK10767 272624005408 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272624005409 HSP70 interaction site [polypeptide binding]; other site 272624005410 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 272624005411 substrate binding site [polypeptide binding]; other site 272624005412 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272624005413 Zn binding sites [ion binding]; other site 272624005414 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272624005415 dimer interface [polypeptide binding]; other site 272624005416 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272624005417 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272624005418 nucleotide binding site [chemical binding]; other site 272624005419 GrpE; Region: GrpE; pfam01025 272624005420 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272624005421 dimer interface [polypeptide binding]; other site 272624005422 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272624005423 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 272624005424 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 272624005425 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272624005426 substrate binding site [chemical binding]; other site 272624005427 active site 272624005428 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272624005429 homooctamer interface [polypeptide binding]; other site 272624005430 active site 272624005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 272624005432 Sporulation related domain; Region: SPOR; pfam05036 272624005433 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272624005434 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 272624005435 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272624005436 active site 272624005437 HIGH motif; other site 272624005438 nucleotide binding site [chemical binding]; other site 272624005439 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272624005440 KMSK motif region; other site 272624005441 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272624005442 tRNA binding surface [nucleotide binding]; other site 272624005443 anticodon binding site; other site 272624005444 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272624005445 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272624005446 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272624005447 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272624005448 generic binding surface II; other site 272624005449 ssDNA binding site; other site 272624005450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624005451 ATP binding site [chemical binding]; other site 272624005452 putative Mg++ binding site [ion binding]; other site 272624005453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624005454 nucleotide binding region [chemical binding]; other site 272624005455 ATP-binding site [chemical binding]; other site 272624005456 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272624005457 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 272624005458 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 272624005459 ZIP Zinc transporter; Region: Zip; pfam02535 272624005460 Maf-like protein; Region: Maf; pfam02545 272624005461 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272624005462 active site 272624005463 dimer interface [polypeptide binding]; other site 272624005464 enolase; Provisional; Region: eno; PRK00077 272624005465 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272624005466 dimer interface [polypeptide binding]; other site 272624005467 metal binding site [ion binding]; metal-binding site 272624005468 substrate binding pocket [chemical binding]; other site 272624005469 Septum formation initiator; Region: DivIC; cl17659 272624005470 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272624005471 mevalonate kinase; Region: mevalon_kin; TIGR00549 272624005472 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272624005473 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 272624005474 diphosphomevalonate decarboxylase; Region: PLN02407 272624005475 diphosphomevalonate decarboxylase; Region: PLN02407 272624005476 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 272624005477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624005478 FeS/SAM binding site; other site 272624005479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624005480 binding surface 272624005481 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 272624005482 TPR motif; other site 272624005483 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272624005484 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272624005485 ligand binding site [chemical binding]; other site 272624005486 Protein of unknown function (DUF330); Region: DUF330; cl01135 272624005487 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 272624005488 mce related protein; Region: MCE; pfam02470 272624005489 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 272624005490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624005491 Walker A/P-loop; other site 272624005492 ATP binding site [chemical binding]; other site 272624005493 Q-loop/lid; other site 272624005494 ABC transporter signature motif; other site 272624005495 Walker B; other site 272624005496 D-loop; other site 272624005497 H-loop/switch region; other site 272624005498 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 272624005499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272624005500 Permease; Region: Permease; pfam02405 272624005501 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272624005502 active site 272624005503 ATP binding site [chemical binding]; other site 272624005504 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272624005505 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272624005506 homotetramer interface [polypeptide binding]; other site 272624005507 FMN binding site [chemical binding]; other site 272624005508 homodimer contacts [polypeptide binding]; other site 272624005509 putative active site [active] 272624005510 putative substrate binding site [chemical binding]; other site 272624005511 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 272624005512 homodimer interface [polypeptide binding]; other site 272624005513 catalytic residues [active] 272624005514 NAD binding site [chemical binding]; other site 272624005515 substrate binding pocket [chemical binding]; other site 272624005516 flexible flap; other site 272624005517 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 272624005518 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272624005519 active site 272624005520 DNA binding site [nucleotide binding] 272624005521 Int/Topo IB signature motif; other site 272624005522 DNA binding domain, excisionase family; Region: excise; TIGR01764 272624005523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624005524 non-specific DNA binding site [nucleotide binding]; other site 272624005525 salt bridge; other site 272624005526 sequence-specific DNA binding site [nucleotide binding]; other site 272624005527 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 272624005528 Catalytic site [active] 272624005529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624005530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624005531 putative substrate translocation pore; other site 272624005532 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 272624005533 active site 272624005534 SAM binding site [chemical binding]; other site 272624005535 homodimer interface [polypeptide binding]; other site 272624005536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624005537 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272624005538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624005539 Walker A/P-loop; other site 272624005540 ATP binding site [chemical binding]; other site 272624005541 Q-loop/lid; other site 272624005542 ABC transporter signature motif; other site 272624005543 Walker B; other site 272624005544 D-loop; other site 272624005545 H-loop/switch region; other site 272624005546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624005547 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 272624005548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624005549 Walker A/P-loop; other site 272624005550 ATP binding site [chemical binding]; other site 272624005551 Q-loop/lid; other site 272624005552 ABC transporter signature motif; other site 272624005553 Walker B; other site 272624005554 D-loop; other site 272624005555 H-loop/switch region; other site 272624005556 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272624005557 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272624005558 active site 272624005559 catalytic tetrad [active] 272624005560 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272624005561 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272624005562 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 272624005563 putative metal binding site [ion binding]; other site 272624005564 Uncharacterized conserved protein [Function unknown]; Region: COG1432 272624005565 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 272624005566 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272624005567 homodimer interface [polypeptide binding]; other site 272624005568 active site 272624005569 putative chemical substrate binding site [chemical binding]; other site 272624005570 metal binding site [ion binding]; metal-binding site 272624005571 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 272624005572 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 272624005573 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272624005574 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272624005575 putative active site [active] 272624005576 putative NTP binding site [chemical binding]; other site 272624005577 putative nucleic acid binding site [nucleotide binding]; other site 272624005578 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 272624005579 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 272624005580 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 272624005581 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 272624005582 AAA domain; Region: AAA_30; pfam13604 272624005583 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 272624005584 active site 272624005585 metal binding site [ion binding]; metal-binding site 272624005586 interdomain interaction site; other site 272624005587 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 272624005588 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624005589 Walker A motif; other site 272624005590 ATP binding site [chemical binding]; other site 272624005591 Walker B motif; other site 272624005592 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 272624005593 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 272624005594 type-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB; Region: TrbB; TIGR02738 272624005595 type-F conjugative transfer system pilin assembly protein TraF; Region: TraF; TIGR02739 272624005596 F plasmid transfer operon protein; Region: TraF; pfam13728 272624005597 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 272624005598 type-F conjugative transfer system pilin assembly protein TrbC; Region: TrbC_Ftype; TIGR02742 272624005599 TraU protein; Region: TraU; cl06067 272624005600 type-F conjugative transfer system protein TraW; Region: TraW; TIGR02743 272624005601 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 272624005602 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 272624005603 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 272624005604 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 272624005605 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272624005606 TraK protein; Region: TraK; pfam06586 272624005607 type-F conjugative transfer system secretin TraK; Region: TraK_Ftype; TIGR02756 272624005608 type IV conjugative transfer system protein TraE; Region: TraE_TIGR; TIGR02761 272624005609 type IV conjugative transfer system protein TraL; Region: TraL_TIGR; TIGR02762 272624005610 Global regulator protein family; Region: CsrA; pfam02599 272624005611 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272624005612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624005613 non-specific DNA binding site [nucleotide binding]; other site 272624005614 salt bridge; other site 272624005615 sequence-specific DNA binding site [nucleotide binding]; other site 272624005616 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272624005617 Catalytic site [active] 272624005618 DDE superfamily endonuclease; Region: DDE_5; cl17874 272624005619 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 272624005620 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272624005621 SelR domain; Region: SelR; pfam01641 272624005622 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272624005623 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272624005624 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272624005625 mercuric reductase; Validated; Region: PRK06370 272624005626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272624005627 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272624005628 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 272624005629 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 272624005630 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 272624005631 MAPEG family; Region: MAPEG; cl09190 272624005632 Predicted membrane protein [Function unknown]; Region: COG2259 272624005633 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 272624005634 hypothetical protein; Provisional; Region: PRK05409 272624005635 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 272624005636 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 272624005637 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272624005638 SelR domain; Region: SelR; pfam01641 272624005639 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 272624005640 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 272624005641 Abi-like protein; Region: Abi_2; pfam07751 272624005642 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 272624005643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624005644 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624005645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624005646 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624005647 Helix-turn-helix domain; Region: HTH_28; pfam13518 272624005648 Winged helix-turn helix; Region: HTH_29; pfam13551 272624005649 Homeodomain-like domain; Region: HTH_32; pfam13565 272624005650 Integrase core domain; Region: rve; pfam00665 272624005651 Integrase core domain; Region: rve_3; pfam13683 272624005652 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 272624005653 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272624005654 DNA-binding site [nucleotide binding]; DNA binding site 272624005655 RNA-binding motif; other site 272624005656 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 272624005657 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272624005658 ATP binding site [chemical binding]; other site 272624005659 Mg++ binding site [ion binding]; other site 272624005660 motif III; other site 272624005661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624005662 nucleotide binding region [chemical binding]; other site 272624005663 ATP-binding site [chemical binding]; other site 272624005664 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 272624005665 putative RNA binding site [nucleotide binding]; other site 272624005666 Cation efflux family; Region: Cation_efflux; cl00316 272624005667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272624005668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272624005669 ligand binding site [chemical binding]; other site 272624005670 K+ potassium transporter; Region: K_trans; pfam02705 272624005671 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624005672 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272624005673 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624005674 PAS domain S-box; Region: sensory_box; TIGR00229 272624005675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624005676 putative active site [active] 272624005677 heme pocket [chemical binding]; other site 272624005678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624005679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624005680 metal binding site [ion binding]; metal-binding site 272624005681 active site 272624005682 I-site; other site 272624005683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624005684 metabolite-proton symporter; Region: 2A0106; TIGR00883 272624005685 putative substrate translocation pore; other site 272624005686 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 272624005687 Protein export membrane protein; Region: SecD_SecF; cl14618 272624005688 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272624005689 carboxyltransferase (CT) interaction site; other site 272624005690 biotinylation site [posttranslational modification]; other site 272624005691 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624005692 Outer membrane efflux protein; Region: OEP; pfam02321 272624005693 Outer membrane efflux protein; Region: OEP; pfam02321 272624005694 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272624005695 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272624005696 active site 272624005697 ATP binding site [chemical binding]; other site 272624005698 substrate binding site [chemical binding]; other site 272624005699 activation loop (A-loop); other site 272624005700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624005701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624005702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272624005703 dimerization interface [polypeptide binding]; other site 272624005704 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 272624005705 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272624005706 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272624005707 Predicted transcriptional regulators [Transcription]; Region: COG1733 272624005708 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272624005709 classical (c) SDRs; Region: SDR_c; cd05233 272624005710 NAD(P) binding site [chemical binding]; other site 272624005711 active site 272624005712 F-box-like; Region: F-box-like; pfam12937 272624005713 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 272624005714 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624005715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624005716 active site 272624005717 phosphorylation site [posttranslational modification] 272624005718 intermolecular recognition site; other site 272624005719 dimerization interface [polypeptide binding]; other site 272624005720 PAS domain; Region: PAS; smart00091 272624005721 PAS fold; Region: PAS_4; pfam08448 272624005722 putative active site [active] 272624005723 heme pocket [chemical binding]; other site 272624005724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272624005725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624005726 dimer interface [polypeptide binding]; other site 272624005727 phosphorylation site [posttranslational modification] 272624005728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624005729 ATP binding site [chemical binding]; other site 272624005730 Mg2+ binding site [ion binding]; other site 272624005731 G-X-G motif; other site 272624005732 Response regulator receiver domain; Region: Response_reg; pfam00072 272624005733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624005734 active site 272624005735 phosphorylation site [posttranslational modification] 272624005736 intermolecular recognition site; other site 272624005737 dimerization interface [polypeptide binding]; other site 272624005738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624005739 dimer interface [polypeptide binding]; other site 272624005740 phosphorylation site [posttranslational modification] 272624005741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624005742 ATP binding site [chemical binding]; other site 272624005743 Mg2+ binding site [ion binding]; other site 272624005744 G-X-G motif; other site 272624005745 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 272624005746 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272624005747 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624005748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624005749 Walker A/P-loop; other site 272624005750 ATP binding site [chemical binding]; other site 272624005751 Q-loop/lid; other site 272624005752 ABC transporter signature motif; other site 272624005753 Walker B; other site 272624005754 D-loop; other site 272624005755 H-loop/switch region; other site 272624005756 Dot/Icm substrate protein; Region: SidE; pfam12252 272624005757 Dot/Icm substrate protein; Region: SidE; pfam12252 272624005758 Dot/Icm substrate protein; Region: SidE; pfam12252 272624005759 Dot/Icm substrate protein; Region: SidE; pfam12252 272624005760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624005761 S-adenosylmethionine binding site [chemical binding]; other site 272624005762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624005763 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 272624005764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624005765 S-adenosylmethionine binding site [chemical binding]; other site 272624005766 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 272624005767 Helix-turn-helix domain; Region: HTH_18; pfam12833 272624005768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272624005769 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 272624005770 Predicted transcriptional regulator [Transcription]; Region: COG2378 272624005771 HTH domain; Region: HTH_11; pfam08279 272624005772 WYL domain; Region: WYL; pfam13280 272624005773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272624005774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272624005775 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 272624005776 putative dimer interface [polypeptide binding]; other site 272624005777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272624005778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624005779 Coenzyme A binding pocket [chemical binding]; other site 272624005780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624005781 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272624005782 Coenzyme A binding pocket [chemical binding]; other site 272624005783 S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Region: SAM1; COG0499 272624005784 S-adenosyl-L-homocysteine hydrolase, NAD binding domain; Region: AdoHcyase_NAD; smart00997 272624005785 NAD binding site [chemical binding]; other site 272624005786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624005787 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624005788 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 272624005789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272624005790 active site 272624005791 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 272624005792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624005793 catalytic residue [active] 272624005794 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624005795 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624005796 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624005797 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272624005798 N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649 272624005799 putative active site [active] 272624005800 putative substrate binding site [chemical binding]; other site 272624005801 putative cosubstrate binding site; other site 272624005802 catalytic site [active] 272624005803 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 272624005804 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272624005805 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 272624005806 acyl-activating enzyme (AAE) consensus motif; other site 272624005807 AMP binding site [chemical binding]; other site 272624005808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272624005809 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 272624005810 PAS domain; Region: PAS; smart00091 272624005811 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 272624005812 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 272624005813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624005814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272624005815 dimer interface [polypeptide binding]; other site 272624005816 phosphorylation site [posttranslational modification] 272624005817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624005818 ATP binding site [chemical binding]; other site 272624005819 Mg2+ binding site [ion binding]; other site 272624005820 G-X-G motif; other site 272624005821 Response regulator receiver domain; Region: Response_reg; pfam00072 272624005822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624005823 active site 272624005824 phosphorylation site [posttranslational modification] 272624005825 intermolecular recognition site; other site 272624005826 dimerization interface [polypeptide binding]; other site 272624005827 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272624005828 putative binding surface; other site 272624005829 active site 272624005830 PAS fold; Region: PAS_4; pfam08448 272624005831 Response regulator receiver domain; Region: Response_reg; pfam00072 272624005832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624005833 active site 272624005834 phosphorylation site [posttranslational modification] 272624005835 intermolecular recognition site; other site 272624005836 dimerization interface [polypeptide binding]; other site 272624005837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624005838 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272624005839 S-adenosylmethionine binding site [chemical binding]; other site 272624005840 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272624005841 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 272624005842 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272624005843 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272624005844 active site 272624005845 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272624005846 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272624005847 active site 272624005848 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 272624005849 KR domain; Region: KR; pfam08659 272624005850 NADP binding site [chemical binding]; other site 272624005851 active site 272624005852 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272624005853 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 272624005854 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 272624005855 active site 272624005856 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 272624005857 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 272624005858 KR domain; Region: KR; pfam08659 272624005859 putative NADP binding site [chemical binding]; other site 272624005860 active site 272624005861 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 272624005862 Condensation domain; Region: Condensation; pfam00668 272624005863 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 272624005864 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624005865 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624005866 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 272624005867 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272624005868 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272624005869 putative dimer interface [polypeptide binding]; other site 272624005870 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272624005871 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272624005872 putative dimer interface [polypeptide binding]; other site 272624005873 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272624005874 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272624005875 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272624005876 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 272624005877 active site clefts [active] 272624005878 zinc binding site [ion binding]; other site 272624005879 dimer interface [polypeptide binding]; other site 272624005880 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 272624005881 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 272624005882 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 272624005883 SnoaL-like domain; Region: SnoaL_3; pfam13474 272624005884 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 272624005885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624005886 putative substrate translocation pore; other site 272624005887 POT family; Region: PTR2; cl17359 272624005888 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 272624005889 hypothetical protein; Reviewed; Region: PRK09588 272624005890 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 272624005891 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 272624005892 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 272624005893 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272624005894 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272624005895 putative NAD(P) binding site [chemical binding]; other site 272624005896 dimer interface [polypeptide binding]; other site 272624005897 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272624005898 substrate binding site [chemical binding]; other site 272624005899 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 272624005900 YARHG domain; Region: YARHG; pfam13308 272624005901 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 272624005902 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 272624005903 active site 272624005904 metal binding site [ion binding]; metal-binding site 272624005905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624005906 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272624005907 NAD(P) binding site [chemical binding]; other site 272624005908 active site 272624005909 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624005910 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624005911 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 272624005912 active site 272624005913 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272624005914 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272624005915 [2Fe-2S] cluster binding site [ion binding]; other site 272624005916 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272624005917 hydrophobic ligand binding site; other site 272624005918 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272624005919 putative trimer interface [polypeptide binding]; other site 272624005920 putative CoA binding site [chemical binding]; other site 272624005921 Sel1 repeat; Region: Sel1; pfam08238 272624005922 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624005923 Sel1-like repeats; Region: SEL1; smart00671 272624005924 Sel1 repeat; Region: Sel1; pfam08238 272624005925 Sel1-like repeats; Region: SEL1; smart00671 272624005926 Sel1-like repeats; Region: SEL1; smart00671 272624005927 Sel1-like repeats; Region: SEL1; smart00671 272624005928 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 272624005929 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 272624005930 GH3 auxin-responsive promoter; Region: GH3; pfam03321 272624005931 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 272624005932 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272624005933 active site 272624005934 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 272624005935 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 272624005936 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 272624005937 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 272624005938 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 272624005939 active site 272624005940 acyl-CoA synthetase; Validated; Region: PRK05850 272624005941 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 272624005942 acyl-activating enzyme (AAE) consensus motif; other site 272624005943 active site 272624005944 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272624005945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272624005946 acyl-activating enzyme (AAE) consensus motif; other site 272624005947 AMP binding site [chemical binding]; other site 272624005948 active site 272624005949 CoA binding site [chemical binding]; other site 272624005950 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272624005951 classical (c) SDRs; Region: SDR_c; cd05233 272624005952 NAD(P) binding site [chemical binding]; other site 272624005953 active site 272624005954 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272624005955 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272624005956 dimer interface [polypeptide binding]; other site 272624005957 active site 272624005958 CoA binding pocket [chemical binding]; other site 272624005959 Phosphopantetheine attachment site; Region: PP-binding; cl09936 272624005960 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272624005961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624005962 putative substrate translocation pore; other site 272624005963 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 272624005964 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 272624005965 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 272624005966 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 272624005967 Binuclear center (active site) [active] 272624005968 K-pathway; other site 272624005969 Putative proton exit pathway; other site 272624005970 Putative water exit pathway; other site 272624005971 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272624005972 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272624005973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624005974 Walker A/P-loop; other site 272624005975 ATP binding site [chemical binding]; other site 272624005976 Q-loop/lid; other site 272624005977 ABC transporter signature motif; other site 272624005978 Walker B; other site 272624005979 D-loop; other site 272624005980 H-loop/switch region; other site 272624005981 MAPEG family; Region: MAPEG; cl09190 272624005982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624005983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272624005984 hypothetical protein; Validated; Region: PRK07198 272624005985 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 272624005986 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272624005987 dimerization interface [polypeptide binding]; other site 272624005988 active site 272624005989 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 272624005990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624005991 active site 272624005992 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 272624005993 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272624005994 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272624005995 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272624005996 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272624005997 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272624005998 catalytic triad [active] 272624005999 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272624006000 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 272624006001 putative active site [active] 272624006002 metal binding site [ion binding]; metal-binding site 272624006003 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272624006004 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 272624006005 NAD(P) binding site [chemical binding]; other site 272624006006 catalytic residues [active] 272624006007 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272624006008 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272624006009 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 272624006010 hypothetical protein; Provisional; Region: PRK05409 272624006011 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 272624006012 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272624006013 Beta-Casp domain; Region: Beta-Casp; pfam10996 272624006014 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272624006015 BON domain; Region: BON; pfam04972 272624006016 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 272624006017 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 272624006018 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 272624006019 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 272624006020 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 272624006021 dimer interaction site [polypeptide binding]; other site 272624006022 substrate-binding tunnel; other site 272624006023 active site 272624006024 catalytic site [active] 272624006025 substrate binding site [chemical binding]; other site 272624006026 phosphate acetyltransferase; Provisional; Region: PRK11890 272624006027 propionate/acetate kinase; Provisional; Region: PRK12379 272624006028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272624006029 nucleotide binding site [chemical binding]; other site 272624006030 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 272624006031 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272624006032 HSP70 interaction site [polypeptide binding]; other site 272624006033 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272624006034 substrate binding site [polypeptide binding]; other site 272624006035 dimer interface [polypeptide binding]; other site 272624006036 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 272624006037 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 272624006038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272624006039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 272624006040 putative acyl-acceptor binding pocket; other site 272624006041 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 272624006042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272624006043 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 272624006044 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 272624006045 active site 272624006046 probable DNA repair protein; Region: TIGR03623 272624006047 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272624006048 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272624006049 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 272624006050 putative NAD(P) binding site [chemical binding]; other site 272624006051 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272624006052 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 272624006053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272624006054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272624006055 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 272624006056 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 272624006057 putative active site [active] 272624006058 catalytic site [active] 272624006059 putative metal binding site [ion binding]; other site 272624006060 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 272624006061 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 272624006062 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 272624006063 NAD binding site [chemical binding]; other site 272624006064 Phe binding site; other site 272624006065 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 272624006066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006067 S-adenosylmethionine binding site [chemical binding]; other site 272624006068 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 272624006069 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 272624006070 dimer interface [polypeptide binding]; other site 272624006071 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 272624006072 active site 272624006073 Fe binding site [ion binding]; other site 272624006074 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272624006075 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272624006076 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 272624006077 maleylacetoacetate isomerase; Region: maiA; TIGR01262 272624006078 C-terminal domain interface [polypeptide binding]; other site 272624006079 GSH binding site (G-site) [chemical binding]; other site 272624006080 putative dimer interface [polypeptide binding]; other site 272624006081 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 272624006082 dimer interface [polypeptide binding]; other site 272624006083 N-terminal domain interface [polypeptide binding]; other site 272624006084 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 272624006085 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272624006086 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272624006087 putative dimer interface [polypeptide binding]; other site 272624006088 putative anticodon binding site; other site 272624006089 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272624006090 homodimer interface [polypeptide binding]; other site 272624006091 motif 1; other site 272624006092 motif 2; other site 272624006093 active site 272624006094 motif 3; other site 272624006095 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 272624006096 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272624006097 Walker A/P-loop; other site 272624006098 ATP binding site [chemical binding]; other site 272624006099 Q-loop/lid; other site 272624006100 ABC transporter signature motif; other site 272624006101 Walker B; other site 272624006102 D-loop; other site 272624006103 H-loop/switch region; other site 272624006104 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 272624006105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272624006106 FtsX-like permease family; Region: FtsX; pfam02687 272624006107 Pirin-related protein [General function prediction only]; Region: COG1741 272624006108 Pirin; Region: Pirin; pfam02678 272624006109 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272624006110 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 272624006111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272624006112 LysR family transcriptional regulator; Provisional; Region: PRK14997 272624006113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624006114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272624006115 dimerization interface [polypeptide binding]; other site 272624006116 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272624006117 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272624006118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624006119 motif II; other site 272624006120 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 272624006121 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272624006122 RNA binding surface [nucleotide binding]; other site 272624006123 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272624006124 active site 272624006125 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 272624006126 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272624006127 homodimer interface [polypeptide binding]; other site 272624006128 oligonucleotide binding site [chemical binding]; other site 272624006129 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272624006130 ATP-dependent helicase HepA; Validated; Region: PRK04914 272624006131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624006132 ATP binding site [chemical binding]; other site 272624006133 putative Mg++ binding site [ion binding]; other site 272624006134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624006135 nucleotide binding region [chemical binding]; other site 272624006136 ATP-binding site [chemical binding]; other site 272624006137 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624006138 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272624006139 Smr domain; Region: Smr; pfam01713 272624006140 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272624006141 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272624006142 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272624006143 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272624006144 Tetramer interface [polypeptide binding]; other site 272624006145 active site 272624006146 FMN-binding site [chemical binding]; other site 272624006147 HemK family putative methylases; Region: hemK_fam; TIGR00536 272624006148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006149 S-adenosylmethionine binding site [chemical binding]; other site 272624006150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 272624006151 Smr domain; Region: Smr; pfam01713 272624006152 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272624006153 active site residue [active] 272624006154 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272624006155 GSH binding site [chemical binding]; other site 272624006156 catalytic residues [active] 272624006157 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 272624006158 SecA binding site; other site 272624006159 Preprotein binding site; other site 272624006160 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272624006161 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272624006162 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272624006163 glutamate racemase; Provisional; Region: PRK00865 272624006164 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 272624006165 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272624006166 dihydrodipicolinate synthase; Region: dapA; TIGR00674 272624006167 dimer interface [polypeptide binding]; other site 272624006168 active site 272624006169 catalytic residue [active] 272624006170 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 272624006171 classical (c) SDRs; Region: SDR_c; cd05233 272624006172 NAD(P) binding site [chemical binding]; other site 272624006173 active site 272624006174 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 272624006175 nucleophile elbow; other site 272624006176 Patatin phospholipase; Region: DUF3734; pfam12536 272624006177 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 272624006178 flagellar motor protein MotA; Validated; Region: PRK09110 272624006179 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 272624006180 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 272624006181 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272624006182 ligand binding site [chemical binding]; other site 272624006183 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272624006184 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 272624006185 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624006186 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 272624006187 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 272624006188 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624006189 ATP binding site [chemical binding]; other site 272624006190 Walker B motif; other site 272624006191 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 272624006192 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 272624006193 DNA repair protein RadA; Provisional; Region: PRK11823 272624006194 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624006195 Walker A motif; other site 272624006196 ATP binding site [chemical binding]; other site 272624006197 Walker B motif; other site 272624006198 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272624006199 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272624006200 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272624006201 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272624006202 substrate binding pocket [chemical binding]; other site 272624006203 chain length determination region; other site 272624006204 substrate-Mg2+ binding site; other site 272624006205 catalytic residues [active] 272624006206 aspartate-rich region 1; other site 272624006207 active site lid residues [active] 272624006208 aspartate-rich region 2; other site 272624006209 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 272624006210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006211 S-adenosylmethionine binding site [chemical binding]; other site 272624006212 comF family protein; Region: comF; TIGR00201 272624006213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272624006214 active site 272624006215 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 272624006216 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272624006217 active site 272624006218 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272624006219 protein binding site [polypeptide binding]; other site 272624006220 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272624006221 putative substrate binding region [chemical binding]; other site 272624006222 GrpE; Region: GrpE; pfam01025 272624006223 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 272624006224 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 272624006225 tRNA; other site 272624006226 putative tRNA binding site [nucleotide binding]; other site 272624006227 putative NADP binding site [chemical binding]; other site 272624006228 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 272624006229 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272624006230 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272624006231 RF-1 domain; Region: RF-1; pfam00472 272624006232 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272624006233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006234 S-adenosylmethionine binding site [chemical binding]; other site 272624006235 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 272624006236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272624006237 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 272624006238 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272624006239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272624006240 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 272624006241 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 272624006242 putative metal binding site [ion binding]; other site 272624006243 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272624006244 HSP70 interaction site [polypeptide binding]; other site 272624006245 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 272624006246 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272624006247 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 272624006248 active site 272624006249 catalytic triad [active] 272624006250 oxyanion hole [active] 272624006251 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272624006252 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272624006253 ATP binding site [chemical binding]; other site 272624006254 Mg++ binding site [ion binding]; other site 272624006255 motif III; other site 272624006256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272624006257 nucleotide binding region [chemical binding]; other site 272624006258 ATP-binding site [chemical binding]; other site 272624006259 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 272624006260 putative RNA binding site [nucleotide binding]; other site 272624006261 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272624006262 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272624006263 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272624006264 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 272624006265 active site 272624006266 FMN binding site [chemical binding]; other site 272624006267 2,4-decadienoyl-CoA binding site; other site 272624006268 catalytic residue [active] 272624006269 4Fe-4S cluster binding site [ion binding]; other site 272624006270 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 272624006271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272624006272 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 272624006273 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 272624006274 E-class dimer interface [polypeptide binding]; other site 272624006275 P-class dimer interface [polypeptide binding]; other site 272624006276 active site 272624006277 Cu2+ binding site [ion binding]; other site 272624006278 Zn2+ binding site [ion binding]; other site 272624006279 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 272624006280 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 272624006281 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272624006282 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272624006283 dimer interface [polypeptide binding]; other site 272624006284 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272624006285 catalytic triad [active] 272624006286 peroxidatic and resolving cysteines [active] 272624006287 malate dehydrogenase; Provisional; Region: PRK05442 272624006288 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 272624006289 NAD(P) binding site [chemical binding]; other site 272624006290 dimer interface [polypeptide binding]; other site 272624006291 malate binding site [chemical binding]; other site 272624006292 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 272624006293 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272624006294 dimer interface [polypeptide binding]; other site 272624006295 ADP-ribose binding site [chemical binding]; other site 272624006296 active site 272624006297 nudix motif; other site 272624006298 metal binding site [ion binding]; metal-binding site 272624006299 HemN family oxidoreductase; Provisional; Region: PRK05660 272624006300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272624006301 FeS/SAM binding site; other site 272624006302 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272624006303 Amidase; Region: Amidase; pfam01425 272624006304 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272624006305 UGMP family protein; Validated; Region: PRK09604 272624006306 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272624006307 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272624006308 Yqey-like protein; Region: YqeY; pfam09424 272624006309 DNA primase; Validated; Region: dnaG; PRK05667 272624006310 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272624006311 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272624006312 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272624006313 active site 272624006314 metal binding site [ion binding]; metal-binding site 272624006315 interdomain interaction site; other site 272624006316 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272624006317 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 272624006318 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 272624006319 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272624006320 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272624006321 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 272624006322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272624006323 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272624006324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272624006325 DNA binding residues [nucleotide binding] 272624006326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272624006327 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272624006328 breast cancer carboxy-terminal domain; Region: BRCT; smart00292 272624006329 Dimer interface [polypeptide binding]; other site 272624006330 Domain of unknown function (DUF927); Region: DUF927; pfam06048 272624006331 Helix-turn-helix domain; Region: HTH_17; pfam12728 272624006332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624006333 non-specific DNA binding site [nucleotide binding]; other site 272624006334 salt bridge; other site 272624006335 sequence-specific DNA binding site [nucleotide binding]; other site 272624006336 HipA N-terminal domain; Region: couple_hipA; TIGR03071 272624006337 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 272624006338 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272624006339 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272624006340 Cupin domain; Region: Cupin_2; cl17218 272624006341 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272624006342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624006343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624006344 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 272624006345 substrate binding pocket [chemical binding]; other site 272624006346 dimerization interface [polypeptide binding]; other site 272624006347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624006348 non-specific DNA binding site [nucleotide binding]; other site 272624006349 salt bridge; other site 272624006350 sequence-specific DNA binding site [nucleotide binding]; other site 272624006351 HipA N-terminal domain; Region: Couple_hipA; cl11853 272624006352 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272624006353 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272624006354 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 272624006355 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624006356 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272624006357 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272624006358 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272624006359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624006360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624006361 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272624006362 putative effector binding pocket; other site 272624006363 dimerization interface [polypeptide binding]; other site 272624006364 potassium uptake protein; Region: kup; TIGR00794 272624006365 K+ potassium transporter; Region: K_trans; pfam02705 272624006366 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272624006367 active site 272624006368 outer membrane protease; Reviewed; Region: PRK10993 272624006369 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272624006370 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 272624006371 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 272624006372 dimer interface [polypeptide binding]; other site 272624006373 active site 272624006374 heme binding site [chemical binding]; other site 272624006375 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 272624006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624006377 metabolite-proton symporter; Region: 2A0106; TIGR00883 272624006378 putative substrate translocation pore; other site 272624006379 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624006380 Substrate binding site [chemical binding]; other site 272624006381 Ferritin-like domain; Region: Ferritin; pfam00210 272624006382 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272624006383 dinuclear metal binding motif [ion binding]; other site 272624006384 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272624006385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006386 S-adenosylmethionine binding site [chemical binding]; other site 272624006387 Peptidase family M23; Region: Peptidase_M23; pfam01551 272624006388 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272624006389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272624006390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272624006391 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 272624006392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 272624006393 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 272624006394 Leucine-rich repeats; other site 272624006395 Substrate binding site [chemical binding]; other site 272624006396 Beta-lactamase; Region: Beta-lactamase; pfam00144 272624006397 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272624006398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272624006399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272624006400 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 272624006401 putative substrate binding pocket [chemical binding]; other site 272624006402 putative dimerization interface [polypeptide binding]; other site 272624006403 trans-cinnamate 4-monooxygenase; Region: PLN02394 272624006404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272624006405 nudix motif; other site 272624006406 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 272624006407 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 272624006408 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272624006409 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 272624006410 active site 272624006411 nucleophile elbow; other site 272624006412 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 272624006413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272624006414 Ras GTPase Activating Domain; Region: RasGAP; cl02569 272624006415 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 272624006416 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 272624006417 Beta-lactamase; Region: Beta-lactamase; pfam00144 272624006418 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272624006419 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272624006420 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272624006421 Coenzyme A binding pocket [chemical binding]; other site 272624006422 Winged helix-turn helix; Region: HTH_29; pfam13551 272624006423 Helix-turn-helix domain; Region: HTH_28; pfam13518 272624006424 Integrase core domain; Region: rve; pfam00665 272624006425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272624006426 Integrase core domain; Region: rve_3; pfam13683 272624006427 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 272624006428 Coenzyme A transferase; Region: CoA_trans; cl17247 272624006429 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 272624006430 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 272624006431 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 272624006432 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 272624006433 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 272624006434 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 272624006435 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272624006436 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 272624006437 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272624006438 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272624006439 active site 272624006440 metal binding site [ion binding]; metal-binding site 272624006441 Cupin domain; Region: Cupin_2; cl17218 272624006442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624006443 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272624006444 putative substrate translocation pore; other site 272624006445 Predicted flavoprotein [General function prediction only]; Region: COG0431 272624006446 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272624006447 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 272624006448 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 272624006449 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 272624006450 putative dimer interface [polypeptide binding]; other site 272624006451 N-terminal domain interface [polypeptide binding]; other site 272624006452 putative substrate binding pocket (H-site) [chemical binding]; other site 272624006453 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272624006454 dimer interface [polypeptide binding]; other site 272624006455 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272624006456 dimer interface [polypeptide binding]; other site 272624006457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272624006458 identified by homology, endonuclease containing URI domain, pseudogene 272624006459 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272624006460 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 272624006461 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 272624006462 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 272624006463 N-acetyltransferase; Region: Acetyltransf_2; cl00949 272624006464 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272624006465 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 272624006466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272624006467 Coenzyme A binding pocket [chemical binding]; other site 272624006468 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 272624006469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624006470 active site 272624006471 phosphorylation site [posttranslational modification] 272624006472 intermolecular recognition site; other site 272624006473 dimerization interface [polypeptide binding]; other site 272624006474 PAS domain S-box; Region: sensory_box; TIGR00229 272624006475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624006476 putative active site [active] 272624006477 heme pocket [chemical binding]; other site 272624006478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624006479 dimer interface [polypeptide binding]; other site 272624006480 phosphorylation site [posttranslational modification] 272624006481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624006482 ATP binding site [chemical binding]; other site 272624006483 Mg2+ binding site [ion binding]; other site 272624006484 G-X-G motif; other site 272624006485 Heme NO binding; Region: HNOB; pfam07700 272624006486 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 272624006487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006488 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 272624006489 guanine nucleotide-exchange factor domain of Legionella SidM/DrrA; Region: SidM_DrrA_GEF; cd11689 272624006490 Rab1 interaction interface [polypeptide binding]; other site 272624006491 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 272624006492 nickel binding site [ion binding]; other site 272624006493 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 272624006494 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 272624006495 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 272624006496 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 272624006497 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 272624006498 FAD binding pocket [chemical binding]; other site 272624006499 FAD binding motif [chemical binding]; other site 272624006500 phosphate binding motif [ion binding]; other site 272624006501 beta-alpha-beta structure motif; other site 272624006502 NAD binding pocket [chemical binding]; other site 272624006503 Iron coordination center [ion binding]; other site 272624006504 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 272624006505 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 272624006506 dimerization interface [polypeptide binding]; other site 272624006507 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 272624006508 ATP binding site [chemical binding]; other site 272624006509 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 272624006510 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 272624006511 HupF/HypC family; Region: HupF_HypC; pfam01455 272624006512 Acylphosphatase; Region: Acylphosphatase; pfam00708 272624006513 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 272624006514 HypF finger; Region: zf-HYPF; pfam07503 272624006515 HypF finger; Region: zf-HYPF; pfam07503 272624006516 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272624006517 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272624006518 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 272624006519 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 272624006520 High-affinity nickel-transport protein; Region: NicO; cl00964 272624006521 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272624006522 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272624006523 Ligand binding site; other site 272624006524 Putative Catalytic site; other site 272624006525 DXD motif; other site 272624006526 GtrA-like protein; Region: GtrA; pfam04138 272624006527 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 272624006528 putative active site [active] 272624006529 YdjC motif; other site 272624006530 Mg binding site [ion binding]; other site 272624006531 putative homodimer interface [polypeptide binding]; other site 272624006532 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 272624006533 EamA-like transporter family; Region: EamA; pfam00892 272624006534 EamA-like transporter family; Region: EamA; pfam00892 272624006535 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624006536 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272624006537 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272624006538 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272624006539 active site 272624006540 dimerization interface [polypeptide binding]; other site 272624006541 TPR repeat; Region: TPR_11; pfam13414 272624006542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624006543 binding surface 272624006544 TPR motif; other site 272624006545 TPR repeat; Region: TPR_11; pfam13414 272624006546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624006547 binding surface 272624006548 TPR repeat; Region: TPR_11; pfam13414 272624006549 TPR motif; other site 272624006550 TPR repeat; Region: TPR_11; pfam13414 272624006551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624006552 binding surface 272624006553 TPR repeat; Region: TPR_11; pfam13414 272624006554 TPR motif; other site 272624006555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624006556 binding surface 272624006557 TPR motif; other site 272624006558 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 272624006559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272624006560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006561 S-adenosylmethionine binding site [chemical binding]; other site 272624006562 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272624006563 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 272624006564 active site 272624006565 substrate binding site [chemical binding]; other site 272624006566 metal binding site [ion binding]; metal-binding site 272624006567 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272624006568 trimer interface [polypeptide binding]; other site 272624006569 active site 272624006570 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272624006571 Flavoprotein; Region: Flavoprotein; pfam02441 272624006572 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 272624006573 hypothetical protein; Reviewed; Region: PRK00024 272624006574 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272624006575 MPN+ (JAMM) motif; other site 272624006576 Zinc-binding site [ion binding]; other site 272624006577 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272624006578 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 272624006579 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272624006580 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272624006581 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 272624006582 putative NAD(P) binding site [chemical binding]; other site 272624006583 putative substrate binding site [chemical binding]; other site 272624006584 catalytic Zn binding site [ion binding]; other site 272624006585 structural Zn binding site [ion binding]; other site 272624006586 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272624006587 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272624006588 putative dimer interface [polypeptide binding]; other site 272624006589 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 272624006590 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 272624006591 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 272624006592 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272624006593 Thiamine pyrophosphokinase; Region: TPK; cd07995 272624006594 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 272624006595 active site 272624006596 dimerization interface [polypeptide binding]; other site 272624006597 thiamine binding site [chemical binding]; other site 272624006598 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272624006599 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 272624006600 active site clefts [active] 272624006601 zinc binding site [ion binding]; other site 272624006602 dimer interface [polypeptide binding]; other site 272624006603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624006604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272624006605 putative substrate translocation pore; other site 272624006606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272624006607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272624006608 dimer interface [polypeptide binding]; other site 272624006609 phosphorylation site [posttranslational modification] 272624006610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624006611 ATP binding site [chemical binding]; other site 272624006612 Mg2+ binding site [ion binding]; other site 272624006613 G-X-G motif; other site 272624006614 Dot/Icm substrate protein; Region: SidE; pfam12252 272624006615 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272624006616 Protein export membrane protein; Region: SecD_SecF; cl14618 272624006617 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624006618 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624006619 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624006620 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272624006621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 272624006622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624006623 D-galactonate transporter; Region: 2A0114; TIGR00893 272624006624 putative substrate translocation pore; other site 272624006625 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272624006626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272624006627 putative DNA binding site [nucleotide binding]; other site 272624006628 putative Zn2+ binding site [ion binding]; other site 272624006629 AsnC family; Region: AsnC_trans_reg; pfam01037 272624006630 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 272624006631 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 272624006632 dimer interface [polypeptide binding]; other site 272624006633 active site 272624006634 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272624006635 substrate binding site [chemical binding]; other site 272624006636 catalytic residue [active] 272624006637 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 272624006638 active site 272624006639 conformational flexibility of ligand binding pocket; other site 272624006640 ADP-ribosylating toxin turn-turn motif; other site 272624006641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272624006642 DNA binding residues [nucleotide binding] 272624006643 dimerization interface [polypeptide binding]; other site 272624006644 F-box-like; Region: F-box-like; pfam12937 272624006645 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 272624006646 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272624006647 active site 272624006648 catalytic site [active] 272624006649 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 272624006650 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272624006651 Prephenate dehydratase; Region: PDT; pfam00800 272624006652 aspartate aminotransferase; Provisional; Region: PRK05764 272624006653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272624006654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624006655 homodimer interface [polypeptide binding]; other site 272624006656 catalytic residue [active] 272624006657 tellurite resistance protein TehB; Provisional; Region: PRK12335 272624006658 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 272624006659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006660 S-adenosylmethionine binding site [chemical binding]; other site 272624006661 Transcriptional regulator; Region: Rrf2; cl17282 272624006662 Rrf2 family protein; Region: rrf2_super; TIGR00738 272624006663 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 272624006664 apolar tunnel; other site 272624006665 heme binding site [chemical binding]; other site 272624006666 dimerization interface [polypeptide binding]; other site 272624006667 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 272624006668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272624006669 catalytic loop [active] 272624006670 iron binding site [ion binding]; other site 272624006671 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 272624006672 FAD binding pocket [chemical binding]; other site 272624006673 FAD binding motif [chemical binding]; other site 272624006674 phosphate binding motif [ion binding]; other site 272624006675 beta-alpha-beta structure motif; other site 272624006676 NAD binding pocket [chemical binding]; other site 272624006677 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 272624006678 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 272624006679 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272624006680 MltA specific insert domain; Region: MltA; cl08398 272624006681 3D domain; Region: 3D; pfam06725 272624006682 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 272624006683 dimer interface [polypeptide binding]; other site 272624006684 putative tRNA-binding site [nucleotide binding]; other site 272624006685 EamA-like transporter family; Region: EamA; pfam00892 272624006686 EamA-like transporter family; Region: EamA; pfam00892 272624006687 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272624006688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272624006689 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 272624006690 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272624006691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624006692 putative substrate translocation pore; other site 272624006693 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 272624006694 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272624006695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272624006696 active site 272624006697 motif I; other site 272624006698 motif II; other site 272624006699 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272624006700 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272624006701 active site 272624006702 ATP binding site [chemical binding]; other site 272624006703 substrate binding site [chemical binding]; other site 272624006704 activation loop (A-loop); other site 272624006705 PAS domain; Region: PAS_9; pfam13426 272624006706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272624006707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272624006708 DNA binding residues [nucleotide binding] 272624006709 dimerization interface [polypeptide binding]; other site 272624006710 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272624006711 DNA binding site [nucleotide binding] 272624006712 active site 272624006713 Int/Topo IB signature motif; other site 272624006714 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 272624006715 Divergent AAA domain; Region: AAA_4; pfam04326 272624006716 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 272624006717 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272624006718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624006719 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272624006720 non-specific DNA binding site [nucleotide binding]; other site 272624006721 salt bridge; other site 272624006722 sequence-specific DNA binding site [nucleotide binding]; other site 272624006723 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272624006724 Catalytic site [active] 272624006725 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 272624006726 Transposase; Region: HTH_Tnp_1; pfam01527 272624006727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272624006728 HTH-like domain; Region: HTH_21; pfam13276 272624006729 Integrase core domain; Region: rve; pfam00665 272624006730 Integrase core domain; Region: rve_3; pfam13683 272624006731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272624006732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624006733 non-specific DNA binding site [nucleotide binding]; other site 272624006734 salt bridge; other site 272624006735 sequence-specific DNA binding site [nucleotide binding]; other site 272624006736 transposase (invertase, resolvase), pseudogene 272624006737 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272624006738 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272624006739 catalytic residues [active] 272624006740 catalytic nucleophile [active] 272624006741 Presynaptic Site I dimer interface [polypeptide binding]; other site 272624006742 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272624006743 Synaptic Flat tetramer interface [polypeptide binding]; other site 272624006744 Synaptic Site I dimer interface [polypeptide binding]; other site 272624006745 DNA binding site [nucleotide binding] 272624006746 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272624006747 DNA-binding interface [nucleotide binding]; DNA binding site 272624006748 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 272624006749 Uncharacterized conserved protein [Function unknown]; Region: COG3189 272624006750 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272624006751 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272624006752 active site 272624006753 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272624006754 tetramer interface [polypeptide binding]; other site 272624006755 TPP-binding site [chemical binding]; other site 272624006756 heterodimer interface [polypeptide binding]; other site 272624006757 phosphorylation loop region [posttranslational modification] 272624006758 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272624006759 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 272624006760 PYR/PP interface [polypeptide binding]; other site 272624006761 dimer interface [polypeptide binding]; other site 272624006762 TPP binding site [chemical binding]; other site 272624006763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272624006764 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 272624006765 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 272624006766 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 272624006767 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 272624006768 active site 272624006769 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 272624006770 active site 272624006771 catalytic triad [active] 272624006772 oxyanion hole [active] 272624006773 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272624006774 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272624006775 active site 272624006776 metal binding site [ion binding]; metal-binding site 272624006777 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 272624006778 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 272624006779 ParB-like nuclease domain; Region: ParBc; pfam02195 272624006780 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272624006781 16S rRNA methyltransferase B; Provisional; Region: PRK10901 272624006782 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 272624006783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624006784 S-adenosylmethionine binding site [chemical binding]; other site 272624006785 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272624006786 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272624006787 putative active site [active] 272624006788 substrate binding site [chemical binding]; other site 272624006789 putative cosubstrate binding site; other site 272624006790 catalytic site [active] 272624006791 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272624006792 substrate binding site [chemical binding]; other site 272624006793 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272624006794 active site 272624006795 catalytic residues [active] 272624006796 metal binding site [ion binding]; metal-binding site 272624006797 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624006798 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272624006799 DNA protecting protein DprA; Region: dprA; TIGR00732 272624006800 Protein of unknown function (DUF494); Region: DUF494; cl01103 272624006801 DNA topoisomerase I; Validated; Region: PRK06599 272624006802 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272624006803 active site 272624006804 interdomain interaction site; other site 272624006805 putative metal-binding site [ion binding]; other site 272624006806 nucleotide binding site [chemical binding]; other site 272624006807 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272624006808 domain I; other site 272624006809 DNA binding groove [nucleotide binding] 272624006810 phosphate binding site [ion binding]; other site 272624006811 domain II; other site 272624006812 domain III; other site 272624006813 nucleotide binding site [chemical binding]; other site 272624006814 catalytic site [active] 272624006815 domain IV; other site 272624006816 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272624006817 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 272624006818 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272624006819 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272624006820 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272624006821 Bacterial PH domain; Region: DUF304; pfam03703 272624006822 Protein of unknown function (DUF721); Region: DUF721; pfam05258 272624006823 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272624006824 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272624006825 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272624006826 Uncharacterized conserved protein [Function unknown]; Region: COG4278 272624006827 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 272624006828 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272624006829 putative active site [active] 272624006830 putative dimer interface [polypeptide binding]; other site 272624006831 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272624006832 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272624006833 active site 272624006834 Zn binding site [ion binding]; other site 272624006835 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 272624006836 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272624006837 cell division protein FtsZ; Validated; Region: PRK09330 272624006838 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272624006839 nucleotide binding site [chemical binding]; other site 272624006840 SulA interaction site; other site 272624006841 cell division protein FtsA; Region: ftsA; TIGR01174 272624006842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272624006843 nucleotide binding site [chemical binding]; other site 272624006844 Cell division protein FtsA; Region: FtsA; pfam14450 272624006845 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272624006846 Cell division protein FtsQ; Region: FtsQ; pfam03799 272624006847 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272624006848 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272624006849 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272624006850 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272624006851 FAD binding domain; Region: FAD_binding_4; pfam01565 272624006852 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272624006853 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272624006854 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272624006855 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272624006856 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272624006857 cell division protein FtsW; Region: ftsW; TIGR02614 272624006858 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 272624006859 TrkA-N domain; Region: TrkA_N; pfam02254 272624006860 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272624006861 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272624006862 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 272624006863 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272624006864 Mg++ binding site [ion binding]; other site 272624006865 putative catalytic motif [active] 272624006866 putative substrate binding site [chemical binding]; other site 272624006867 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272624006868 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 272624006869 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272624006870 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272624006871 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 272624006872 FtsZ protein binding site [polypeptide binding]; other site 272624006873 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272624006874 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272624006875 Walker A/P-loop; other site 272624006876 ATP binding site [chemical binding]; other site 272624006877 Q-loop/lid; other site 272624006878 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 272624006879 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272624006880 Q-loop/lid; other site 272624006881 ABC transporter signature motif; other site 272624006882 Walker B; other site 272624006883 D-loop; other site 272624006884 H-loop/switch region; other site 272624006885 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 272624006886 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 272624006887 active site 272624006888 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 272624006889 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272624006890 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272624006891 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272624006892 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272624006893 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272624006894 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272624006895 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272624006896 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272624006897 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272624006898 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272624006899 IMP binding site; other site 272624006900 dimer interface [polypeptide binding]; other site 272624006901 interdomain contacts; other site 272624006902 partial ornithine binding site; other site 272624006903 Predicted flavoproteins [General function prediction only]; Region: COG2081 272624006904 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 272624006905 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272624006906 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272624006907 putative active site [active] 272624006908 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 272624006909 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272624006910 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272624006911 Predicted permeases [General function prediction only]; Region: COG0795 272624006912 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272624006913 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272624006914 interface (dimer of trimers) [polypeptide binding]; other site 272624006915 Substrate-binding/catalytic site; other site 272624006916 Zn-binding sites [ion binding]; other site 272624006917 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 272624006918 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 272624006919 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272624006920 interface (dimer of trimers) [polypeptide binding]; other site 272624006921 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 272624006922 Substrate-binding/catalytic site; other site 272624006923 Zn-binding sites [ion binding]; other site 272624006924 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272624006925 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272624006926 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272624006927 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624006928 Sel1-like repeats; Region: SEL1; smart00671 272624006929 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624006930 Sel1-like repeats; Region: SEL1; smart00671 272624006931 Sel1-like repeats; Region: SEL1; smart00671 272624006932 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272624006933 Sel1-like repeats; Region: SEL1; smart00671 272624006934 Sel1-like repeats; Region: SEL1; smart00671 272624006935 Sel1-like repeats; Region: SEL1; smart00671 272624006936 Sel1-like repeats; Region: SEL1; smart00671 272624006937 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272624006938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272624006939 putative active site [active] 272624006940 GAF domain; Region: GAF; pfam01590 272624006941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624006942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624006943 metal binding site [ion binding]; metal-binding site 272624006944 active site 272624006945 I-site; other site 272624006946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272624006947 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272624006948 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272624006949 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272624006950 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272624006951 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272624006952 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 272624006953 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272624006954 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272624006955 GIY-YIG motif/motif A; other site 272624006956 active site 272624006957 catalytic site [active] 272624006958 putative DNA binding site [nucleotide binding]; other site 272624006959 metal binding site [ion binding]; metal-binding site 272624006960 UvrB/uvrC motif; Region: UVR; pfam02151 272624006961 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272624006962 response regulator; Provisional; Region: PRK09483 272624006963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624006964 active site 272624006965 phosphorylation site [posttranslational modification] 272624006966 intermolecular recognition site; other site 272624006967 dimerization interface [polypeptide binding]; other site 272624006968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272624006969 DNA binding residues [nucleotide binding] 272624006970 dimerization interface [polypeptide binding]; other site 272624006971 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 272624006972 cofactor binding site; other site 272624006973 metal binding site [ion binding]; metal-binding site 272624006974 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272624006975 competence damage-inducible protein A; Provisional; Region: PRK01215 272624006976 putative MPT binding site; other site 272624006977 GTPase CgtA; Reviewed; Region: obgE; PRK12299 272624006978 GTP1/OBG; Region: GTP1_OBG; pfam01018 272624006979 Obg GTPase; Region: Obg; cd01898 272624006980 G1 box; other site 272624006981 GTP/Mg2+ binding site [chemical binding]; other site 272624006982 Switch I region; other site 272624006983 G2 box; other site 272624006984 G3 box; other site 272624006985 Switch II region; other site 272624006986 G4 box; other site 272624006987 G5 box; other site 272624006988 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272624006989 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 272624006990 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272624006991 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 272624006992 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272624006993 5S rRNA interface [nucleotide binding]; other site 272624006994 CTC domain interface [polypeptide binding]; other site 272624006995 L16 interface [polypeptide binding]; other site 272624006996 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272624006997 putative active site [active] 272624006998 catalytic residue [active] 272624006999 GTP-binding protein YchF; Reviewed; Region: PRK09601 272624007000 YchF GTPase; Region: YchF; cd01900 272624007001 G1 box; other site 272624007002 GTP/Mg2+ binding site [chemical binding]; other site 272624007003 Switch I region; other site 272624007004 G2 box; other site 272624007005 Switch II region; other site 272624007006 G3 box; other site 272624007007 G4 box; other site 272624007008 G5 box; other site 272624007009 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272624007010 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272624007011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272624007012 metal binding site [ion binding]; metal-binding site 272624007013 active site 272624007014 I-site; other site 272624007015 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272624007016 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272624007017 substrate binding pocket [chemical binding]; other site 272624007018 chain length determination region; other site 272624007019 substrate-Mg2+ binding site; other site 272624007020 catalytic residues [active] 272624007021 aspartate-rich region 1; other site 272624007022 active site lid residues [active] 272624007023 aspartate-rich region 2; other site 272624007024 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 272624007025 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272624007026 G1 box; other site 272624007027 GTP/Mg2+ binding site [chemical binding]; other site 272624007028 Switch I region; other site 272624007029 G2 box; other site 272624007030 G3 box; other site 272624007031 Switch II region; other site 272624007032 G4 box; other site 272624007033 G5 box; other site 272624007034 Nucleoside recognition; Region: Gate; pfam07670 272624007035 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272624007036 Nucleoside recognition; Region: Gate; pfam07670 272624007037 FeoA domain; Region: FeoA; pfam04023 272624007038 Predicted ATPase [General function prediction only]; Region: COG1485 272624007039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272624007040 Walker A motif; other site 272624007041 ATP binding site [chemical binding]; other site 272624007042 Walker B motif; other site 272624007043 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 272624007044 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272624007045 oligomerization interface [polypeptide binding]; other site 272624007046 active site 272624007047 metal binding site [ion binding]; metal-binding site 272624007048 pantoate--beta-alanine ligase; Region: panC; TIGR00018 272624007049 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272624007050 active site 272624007051 nucleotide binding site [chemical binding]; other site 272624007052 HIGH motif; other site 272624007053 KMSKS motif; other site 272624007054 AAA domain; Region: AAA_28; pfam13521 272624007055 Predicted ATPase [General function prediction only]; Region: COG3911 272624007056 pyruvate carboxylase subunit A; Validated; Region: PRK07178 272624007057 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272624007058 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272624007059 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272624007060 Dienelactone hydrolase family; Region: DLH; pfam01738 272624007061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272624007062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624007063 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 272624007064 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272624007065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272624007066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272624007067 DNA binding residues [nucleotide binding] 272624007068 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272624007069 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 272624007070 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 272624007071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624007072 Walker A/P-loop; other site 272624007073 ATP binding site [chemical binding]; other site 272624007074 Q-loop/lid; other site 272624007075 ABC transporter signature motif; other site 272624007076 Walker B; other site 272624007077 D-loop; other site 272624007078 H-loop/switch region; other site 272624007079 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272624007080 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272624007081 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272624007082 P loop; other site 272624007083 GTP binding site [chemical binding]; other site 272624007084 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272624007085 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272624007086 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272624007087 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272624007088 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272624007089 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272624007090 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 272624007091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007092 S-adenosylmethionine binding site [chemical binding]; other site 272624007093 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 272624007094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624007095 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272624007096 Walker A motif; other site 272624007097 Walker A/P-loop; other site 272624007098 ATP binding site [chemical binding]; other site 272624007099 ATP binding site [chemical binding]; other site 272624007100 Walker B motif; other site 272624007101 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272624007102 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 272624007103 putative active site [active] 272624007104 putative metal binding site [ion binding]; other site 272624007105 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272624007106 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272624007107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007108 S-adenosylmethionine binding site [chemical binding]; other site 272624007109 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272624007110 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272624007111 NAD binding site [chemical binding]; other site 272624007112 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272624007113 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 272624007114 active site 272624007115 catalytic residues [active] 272624007116 metal binding site [ion binding]; metal-binding site 272624007117 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 272624007118 tartrate dehydrogenase; Region: TTC; TIGR02089 272624007119 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 272624007120 Dienelactone hydrolase family; Region: DLH; pfam01738 272624007121 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272624007122 Phagosome trafficking protein DotA; Region: DotA; pfam11388 272624007123 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 272624007124 putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539 272624007125 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 272624007126 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 272624007127 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272624007128 metal-binding site [ion binding] 272624007129 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272624007130 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272624007131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007132 S-adenosylmethionine binding site [chemical binding]; other site 272624007133 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 272624007134 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 272624007135 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 272624007136 putative active site [active] 272624007137 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272624007138 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272624007139 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 272624007140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624007141 ATP binding site [chemical binding]; other site 272624007142 Mg2+ binding site [ion binding]; other site 272624007143 G-X-G motif; other site 272624007144 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 272624007145 ATP binding site [chemical binding]; other site 272624007146 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 272624007147 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 272624007148 AMIN domain; Region: AMIN; pfam11741 272624007149 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272624007150 active site 272624007151 metal binding site [ion binding]; metal-binding site 272624007152 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272624007153 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272624007154 putative carbohydrate kinase; Provisional; Region: PRK10565 272624007155 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272624007156 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272624007157 putative substrate binding site [chemical binding]; other site 272624007158 putative ATP binding site [chemical binding]; other site 272624007159 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 272624007160 stringent starvation protein A; Provisional; Region: sspA; PRK09481 272624007161 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 272624007162 C-terminal domain interface [polypeptide binding]; other site 272624007163 putative GSH binding site (G-site) [chemical binding]; other site 272624007164 dimer interface [polypeptide binding]; other site 272624007165 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 272624007166 dimer interface [polypeptide binding]; other site 272624007167 N-terminal domain interface [polypeptide binding]; other site 272624007168 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 272624007169 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 272624007170 Qi binding site; other site 272624007171 intrachain domain interface; other site 272624007172 interchain domain interface [polypeptide binding]; other site 272624007173 cytochrome b; Validated; Region: CYTB; MTH00016 272624007174 heme bH binding site [chemical binding]; other site 272624007175 heme bL binding site [chemical binding]; other site 272624007176 Qo binding site; other site 272624007177 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 272624007178 interchain domain interface [polypeptide binding]; other site 272624007179 intrachain domain interface; other site 272624007180 Qi binding site; other site 272624007181 Qo binding site; other site 272624007182 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 272624007183 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 272624007184 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 272624007185 [2Fe-2S] cluster binding site [ion binding]; other site 272624007186 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272624007187 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272624007188 23S rRNA interface [nucleotide binding]; other site 272624007189 L3 interface [polypeptide binding]; other site 272624007190 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 272624007191 dimer interface [polypeptide binding]; other site 272624007192 [2Fe-2S] cluster binding site [ion binding]; other site 272624007193 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272624007194 IHF - DNA interface [nucleotide binding]; other site 272624007195 IHF dimer interface [polypeptide binding]; other site 272624007196 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272624007197 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272624007198 putative tRNA-binding site [nucleotide binding]; other site 272624007199 B3/4 domain; Region: B3_4; pfam03483 272624007200 tRNA synthetase B5 domain; Region: B5; pfam03484 272624007201 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272624007202 dimer interface [polypeptide binding]; other site 272624007203 motif 1; other site 272624007204 motif 3; other site 272624007205 motif 2; other site 272624007206 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272624007207 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272624007208 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272624007209 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272624007210 dimer interface [polypeptide binding]; other site 272624007211 motif 1; other site 272624007212 active site 272624007213 motif 2; other site 272624007214 motif 3; other site 272624007215 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272624007216 23S rRNA binding site [nucleotide binding]; other site 272624007217 L21 binding site [polypeptide binding]; other site 272624007218 L13 binding site [polypeptide binding]; other site 272624007219 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272624007220 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272624007221 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272624007222 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272624007223 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272624007224 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272624007225 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272624007226 active site 272624007227 dimer interface [polypeptide binding]; other site 272624007228 motif 1; other site 272624007229 motif 2; other site 272624007230 motif 3; other site 272624007231 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272624007232 anticodon binding site; other site 272624007233 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 272624007234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624007235 non-specific DNA binding site [nucleotide binding]; other site 272624007236 salt bridge; other site 272624007237 sequence-specific DNA binding site [nucleotide binding]; other site 272624007238 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 272624007239 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 272624007240 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272624007241 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272624007242 ligand binding site [chemical binding]; other site 272624007243 flexible hinge region; other site 272624007244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272624007245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272624007246 ligand binding site [chemical binding]; other site 272624007247 flexible hinge region; other site 272624007248 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272624007249 putative dimer interface [polypeptide binding]; other site 272624007250 putative active site [active] 272624007251 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272624007252 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272624007253 FMN binding site [chemical binding]; other site 272624007254 active site 272624007255 substrate binding site [chemical binding]; other site 272624007256 catalytic residue [active] 272624007257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272624007258 dimerization interface [polypeptide binding]; other site 272624007259 putative DNA binding site [nucleotide binding]; other site 272624007260 putative Zn2+ binding site [ion binding]; other site 272624007261 Predicted membrane protein [Function unknown]; Region: COG2860 272624007262 UPF0126 domain; Region: UPF0126; pfam03458 272624007263 UPF0126 domain; Region: UPF0126; pfam03458 272624007264 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 272624007265 substrate binding site [chemical binding]; other site 272624007266 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 272624007267 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 272624007268 similar to protein-disulfide oxidoreductase (disulfide bond formation) 272624007269 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 272624007270 hypothetical protein; Provisional; Region: PRK07179 272624007271 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 272624007272 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272624007273 catalytic residue [active] 272624007274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624007275 active site 272624007276 phosphorylation site [posttranslational modification] 272624007277 intermolecular recognition site; other site 272624007278 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272624007279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272624007280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272624007281 ATP binding site [chemical binding]; other site 272624007282 Mg2+ binding site [ion binding]; other site 272624007283 G-X-G motif; other site 272624007284 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272624007285 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272624007286 domain interfaces; other site 272624007287 active site 272624007288 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 272624007289 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272624007290 active site 272624007291 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 272624007292 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 272624007293 HemY protein N-terminus; Region: HemY_N; pfam07219 272624007294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624007295 TPR motif; other site 272624007296 binding surface 272624007297 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272624007298 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272624007299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 272624007300 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 272624007301 catalytic site [active] 272624007302 putative active site [active] 272624007303 putative substrate binding site [chemical binding]; other site 272624007304 dimer interface [polypeptide binding]; other site 272624007305 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 272624007306 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272624007307 active site 272624007308 NTP binding site [chemical binding]; other site 272624007309 metal binding triad [ion binding]; metal-binding site 272624007310 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272624007311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272624007312 Zn2+ binding site [ion binding]; other site 272624007313 Mg2+ binding site [ion binding]; other site 272624007314 GTPase RsgA; Reviewed; Region: PRK12288 272624007315 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272624007316 RNA binding site [nucleotide binding]; other site 272624007317 homodimer interface [polypeptide binding]; other site 272624007318 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272624007319 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272624007320 GTP/Mg2+ binding site [chemical binding]; other site 272624007321 G4 box; other site 272624007322 G5 box; other site 272624007323 G1 box; other site 272624007324 Switch I region; other site 272624007325 G2 box; other site 272624007326 G3 box; other site 272624007327 Switch II region; other site 272624007328 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 272624007329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624007330 Walker A motif; other site 272624007331 ATP binding site [chemical binding]; other site 272624007332 Walker B motif; other site 272624007333 arginine finger; other site 272624007334 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272624007335 hypothetical protein; Validated; Region: PRK00153 272624007336 recombination protein RecR; Reviewed; Region: recR; PRK00076 272624007337 RecR protein; Region: RecR; pfam02132 272624007338 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272624007339 putative active site [active] 272624007340 putative metal-binding site [ion binding]; other site 272624007341 tetramer interface [polypeptide binding]; other site 272624007342 Protein of unknown function, DUF547; Region: DUF547; pfam04784 272624007343 Sulfatase; Region: Sulfatase; cl17466 272624007344 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 272624007345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272624007346 active site 272624007347 dimerization interface [polypeptide binding]; other site 272624007348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272624007349 DNA binding site [nucleotide binding] 272624007350 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 272624007351 Domain of unknown function DUF21; Region: DUF21; pfam01595 272624007352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272624007353 Transporter associated domain; Region: CorC_HlyC; smart01091 272624007354 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272624007355 dimer interface [polypeptide binding]; other site 272624007356 substrate binding site [chemical binding]; other site 272624007357 metal binding sites [ion binding]; metal-binding site 272624007358 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 272624007359 nucleotide binding site/active site [active] 272624007360 HIT family signature motif; other site 272624007361 catalytic residue [active] 272624007362 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 272624007363 GTP cyclohydrolase I; Provisional; Region: PLN03044 272624007364 homodecamer interface [polypeptide binding]; other site 272624007365 active site 272624007366 putative catalytic site residues [active] 272624007367 zinc binding site [ion binding]; other site 272624007368 GTP-CH-I/GFRP interaction surface; other site 272624007369 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 272624007370 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272624007371 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272624007372 RNase E interface [polypeptide binding]; other site 272624007373 trimer interface [polypeptide binding]; other site 272624007374 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272624007375 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272624007376 RNase E interface [polypeptide binding]; other site 272624007377 trimer interface [polypeptide binding]; other site 272624007378 active site 272624007379 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272624007380 putative nucleic acid binding region [nucleotide binding]; other site 272624007381 G-X-X-G motif; other site 272624007382 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272624007383 RNA binding site [nucleotide binding]; other site 272624007384 domain interface; other site 272624007385 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272624007386 16S/18S rRNA binding site [nucleotide binding]; other site 272624007387 S13e-L30e interaction site [polypeptide binding]; other site 272624007388 25S rRNA binding site [nucleotide binding]; other site 272624007389 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 272624007390 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272624007391 RNA binding site [nucleotide binding]; other site 272624007392 active site 272624007393 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 272624007394 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272624007395 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272624007396 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 272624007397 translation initiation factor IF-2; Region: IF-2; TIGR00487 272624007398 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272624007399 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272624007400 G1 box; other site 272624007401 putative GEF interaction site [polypeptide binding]; other site 272624007402 GTP/Mg2+ binding site [chemical binding]; other site 272624007403 Switch I region; other site 272624007404 G2 box; other site 272624007405 G3 box; other site 272624007406 Switch II region; other site 272624007407 G4 box; other site 272624007408 G5 box; other site 272624007409 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272624007410 Translation-initiation factor 2; Region: IF-2; pfam11987 272624007411 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272624007412 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272624007413 NusA N-terminal domain; Region: NusA_N; pfam08529 272624007414 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272624007415 RNA binding site [nucleotide binding]; other site 272624007416 homodimer interface [polypeptide binding]; other site 272624007417 NusA-like KH domain; Region: KH_5; pfam13184 272624007418 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272624007419 G-X-X-G motif; other site 272624007420 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272624007421 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272624007422 ribosome maturation protein RimP; Reviewed; Region: PRK00092 272624007423 Sm and related proteins; Region: Sm_like; cl00259 272624007424 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272624007425 putative oligomer interface [polypeptide binding]; other site 272624007426 putative RNA binding site [nucleotide binding]; other site 272624007427 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272624007428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272624007429 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 272624007430 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272624007431 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272624007432 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272624007433 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272624007434 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 272624007435 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 272624007436 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272624007437 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272624007438 4Fe-4S binding domain; Region: Fer4; cl02805 272624007439 4Fe-4S binding domain; Region: Fer4; pfam00037 272624007440 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272624007441 NADH dehydrogenase subunit G; Validated; Region: PRK09129 272624007442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272624007443 catalytic loop [active] 272624007444 iron binding site [ion binding]; other site 272624007445 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272624007446 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 272624007447 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 272624007448 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 272624007449 SLBB domain; Region: SLBB; pfam10531 272624007450 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 272624007451 NADH dehydrogenase subunit E; Validated; Region: PRK07539 272624007452 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272624007453 putative dimer interface [polypeptide binding]; other site 272624007454 [2Fe-2S] cluster binding site [ion binding]; other site 272624007455 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 272624007456 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272624007457 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 272624007458 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 272624007459 NADH dehydrogenase subunit B; Validated; Region: PRK06411 272624007460 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 272624007461 Preprotein translocase SecG subunit; Region: SecG; pfam03840 272624007462 triosephosphate isomerase; Provisional; Region: PRK14567 272624007463 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272624007464 substrate binding site [chemical binding]; other site 272624007465 dimer interface [polypeptide binding]; other site 272624007466 catalytic triad [active] 272624007467 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272624007468 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 272624007469 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272624007470 active site 272624007471 substrate binding site [chemical binding]; other site 272624007472 metal binding site [ion binding]; metal-binding site 272624007473 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272624007474 dihydropteroate synthase; Region: DHPS; TIGR01496 272624007475 substrate binding pocket [chemical binding]; other site 272624007476 dimer interface [polypeptide binding]; other site 272624007477 inhibitor binding site; inhibition site 272624007478 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 272624007479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624007480 Walker A motif; other site 272624007481 ATP binding site [chemical binding]; other site 272624007482 Walker B motif; other site 272624007483 arginine finger; other site 272624007484 Peptidase family M41; Region: Peptidase_M41; pfam01434 272624007485 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 272624007486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007487 S-adenosylmethionine binding site [chemical binding]; other site 272624007488 identified by homology, RNA-binding protein containing KH domain, pseudogene 272624007489 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272624007490 IucA / IucC family; Region: IucA_IucC; pfam04183 272624007491 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272624007492 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 272624007493 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272624007494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272624007495 Walker A motif; other site 272624007496 ATP binding site [chemical binding]; other site 272624007497 Walker B motif; other site 272624007498 arginine finger; other site 272624007499 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 272624007500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624007501 putative substrate translocation pore; other site 272624007502 POT family; Region: PTR2; cl17359 272624007503 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272624007504 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 272624007505 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272624007506 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272624007507 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272624007508 shikimate binding site; other site 272624007509 NAD(P) binding site [chemical binding]; other site 272624007510 aminopeptidase N; Provisional; Region: pepN; PRK14015 272624007511 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 272624007512 active site 272624007513 Zn binding site [ion binding]; other site 272624007514 PrkA family serine protein kinase; Provisional; Region: PRK15455 272624007515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272624007516 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 272624007517 hypothetical protein; Provisional; Region: PRK05325 272624007518 SpoVR family protein; Provisional; Region: PRK11767 272624007519 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 272624007520 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 272624007521 Peptidase family M28; Region: Peptidase_M28; pfam04389 272624007522 active site 272624007523 metal binding site [ion binding]; metal-binding site 272624007524 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 272624007525 Part of AAA domain; Region: AAA_19; pfam13245 272624007526 Family description; Region: UvrD_C_2; pfam13538 272624007527 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272624007528 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272624007529 dimerization interface [polypeptide binding]; other site 272624007530 domain crossover interface; other site 272624007531 redox-dependent activation switch; other site 272624007532 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 272624007533 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272624007534 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272624007535 active site 272624007536 catalytic tetrad [active] 272624007537 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 272624007538 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272624007539 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272624007540 G1 box; other site 272624007541 putative GEF interaction site [polypeptide binding]; other site 272624007542 GTP/Mg2+ binding site [chemical binding]; other site 272624007543 Switch I region; other site 272624007544 G2 box; other site 272624007545 G3 box; other site 272624007546 Switch II region; other site 272624007547 G4 box; other site 272624007548 G5 box; other site 272624007549 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272624007550 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272624007551 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 272624007552 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 272624007553 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272624007554 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272624007555 Walker A/P-loop; other site 272624007556 ATP binding site [chemical binding]; other site 272624007557 Q-loop/lid; other site 272624007558 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272624007559 ABC transporter signature motif; other site 272624007560 Walker B; other site 272624007561 D-loop; other site 272624007562 H-loop/switch region; other site 272624007563 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272624007564 DNA-binding site [nucleotide binding]; DNA binding site 272624007565 RNA-binding motif; other site 272624007566 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272624007567 conserved cys residue [active] 272624007568 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 272624007569 Amidinotransferase; Region: Amidinotransf; pfam02274 272624007570 U-box domain; Region: U-box; cl17544 272624007571 U-box domain; Region: U-box; cl17544 272624007572 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272624007573 active site 272624007574 nucleophile elbow; other site 272624007575 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 272624007576 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272624007577 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272624007578 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272624007579 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272624007580 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272624007581 RNA binding site [nucleotide binding]; other site 272624007582 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 272624007583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007584 S-adenosylmethionine binding site [chemical binding]; other site 272624007585 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272624007586 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272624007587 glutaminase active site [active] 272624007588 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272624007589 dimer interface [polypeptide binding]; other site 272624007590 active site 272624007591 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272624007592 dimer interface [polypeptide binding]; other site 272624007593 active site 272624007594 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 272624007595 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 272624007596 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 272624007597 active site 272624007598 oxyanion hole [active] 272624007599 catalytic triad [active] 272624007600 rhodanese superfamily protein; Provisional; Region: PRK05320 272624007601 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272624007602 active site residue [active] 272624007603 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272624007604 SmpB-tmRNA interface; other site 272624007605 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272624007606 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272624007607 catalytic triad [active] 272624007608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272624007609 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272624007610 putative substrate translocation pore; other site 272624007611 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 272624007612 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 272624007613 putative active site [active] 272624007614 PhoH-like protein; Region: PhoH; pfam02562 272624007615 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272624007616 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 272624007617 active site 272624007618 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272624007619 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 272624007620 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 272624007621 B1 nucleotide binding pocket [chemical binding]; other site 272624007622 B2 nucleotide binding pocket [chemical binding]; other site 272624007623 CAS motifs; other site 272624007624 active site 272624007625 TPR repeat; Region: TPR_11; pfam13414 272624007626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624007627 TPR motif; other site 272624007628 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 272624007629 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272624007630 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272624007631 DNA-binding site [nucleotide binding]; DNA binding site 272624007632 RNA-binding motif; other site 272624007633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272624007634 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 272624007635 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272624007636 Amidase; Region: Amidase; cl11426 272624007637 Oxygen tolerance; Region: BatD; pfam13584 272624007638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272624007639 binding surface 272624007640 TPR motif; other site 272624007641 Tetratricopeptide repeat; Region: TPR_16; pfam13432 272624007642 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 272624007643 metal ion-dependent adhesion site (MIDAS); other site 272624007644 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 272624007645 metal ion-dependent adhesion site (MIDAS); other site 272624007646 probably truncated or frameshifted gene 272624007647 Protein of unknown function DUF58; Region: DUF58; pfam01882 272624007648 MoxR-like ATPases [General function prediction only]; Region: COG0714 272624007649 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 272624007650 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272624007651 FMN binding site [chemical binding]; other site 272624007652 active site 272624007653 catalytic residues [active] 272624007654 substrate binding site [chemical binding]; other site 272624007655 pteridine reductase; Provisional; Region: PRK09135 272624007656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272624007657 NAD(P) binding site [chemical binding]; other site 272624007658 active site 272624007659 Uncharacterized conserved protein [Function unknown]; Region: COG1565 272624007660 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272624007661 primosome assembly protein PriA; Validated; Region: PRK05580 272624007662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272624007663 ATP binding site [chemical binding]; other site 272624007664 putative Mg++ binding site [ion binding]; other site 272624007665 nucleotide binding region [chemical binding]; other site 272624007666 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272624007667 ATP-binding site [chemical binding]; other site 272624007668 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272624007669 active site 272624007670 thymidylate synthase; Reviewed; Region: thyA; PRK01827 272624007671 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272624007672 dimerization interface [polypeptide binding]; other site 272624007673 active site 272624007674 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272624007675 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272624007676 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 272624007677 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272624007678 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272624007679 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272624007680 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272624007681 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272624007682 putative active site [active] 272624007683 Ap4A binding site [chemical binding]; other site 272624007684 nudix motif; other site 272624007685 putative metal binding site [ion binding]; other site 272624007686 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 272624007687 active site 272624007688 homodimer interface [polypeptide binding]; other site 272624007689 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 272624007690 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272624007691 Substrate binding site; other site 272624007692 Mg++ binding site; other site 272624007693 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272624007694 active site 272624007695 substrate binding site [chemical binding]; other site 272624007696 CoA binding site [chemical binding]; other site 272624007697 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 272624007698 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 272624007699 transmembrane helices; other site 272624007700 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 272624007701 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272624007702 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 272624007703 oligomer interface [polypeptide binding]; other site 272624007704 metal binding site [ion binding]; metal-binding site 272624007705 metal binding site [ion binding]; metal-binding site 272624007706 Cl binding site [ion binding]; other site 272624007707 aspartate ring; other site 272624007708 basic sphincter; other site 272624007709 putative hydrophobic gate; other site 272624007710 periplasmic entrance; other site 272624007711 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272624007712 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272624007713 minor groove reading motif; other site 272624007714 helix-hairpin-helix signature motif; other site 272624007715 substrate binding pocket [chemical binding]; other site 272624007716 active site 272624007717 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272624007718 ferredoxin; Provisional; Region: PRK08764 272624007719 Putative Fe-S cluster; Region: FeS; pfam04060 272624007720 4Fe-4S binding domain; Region: Fer4; pfam00037 272624007721 4Fe-4S binding domain; Region: Fer4; cl02805 272624007722 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 272624007723 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272624007724 active site 272624007725 HIGH motif; other site 272624007726 KMSKS motif; other site 272624007727 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272624007728 anticodon binding site; other site 272624007729 tRNA binding surface [nucleotide binding]; other site 272624007730 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272624007731 dimer interface [polypeptide binding]; other site 272624007732 putative tRNA-binding site [nucleotide binding]; other site 272624007733 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 272624007734 Flavoprotein; Region: Flavoprotein; pfam02441 272624007735 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272624007736 Ligand Binding Site [chemical binding]; other site 272624007737 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 272624007738 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 272624007739 Substrate binding site; other site 272624007740 Cupin domain; Region: Cupin_2; cl17218 272624007741 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272624007742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272624007743 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272624007744 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272624007745 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 272624007746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007747 S-adenosylmethionine binding site [chemical binding]; other site 272624007748 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272624007749 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272624007750 P-loop; other site 272624007751 Magnesium ion binding site [ion binding]; other site 272624007752 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272624007753 Magnesium ion binding site [ion binding]; other site 272624007754 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272624007755 ParB-like nuclease domain; Region: ParBc; pfam02195 272624007756 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 272624007757 Subunit III/VIIa interface [polypeptide binding]; other site 272624007758 Phospholipid binding site [chemical binding]; other site 272624007759 Subunit I/III interface [polypeptide binding]; other site 272624007760 Subunit III/VIb interface [polypeptide binding]; other site 272624007761 Subunit III/VIa interface; other site 272624007762 Subunit III/Vb interface [polypeptide binding]; other site 272624007763 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 272624007764 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 272624007765 Subunit I/III interface [polypeptide binding]; other site 272624007766 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 272624007767 D-pathway; other site 272624007768 Subunit I/VIIc interface [polypeptide binding]; other site 272624007769 Subunit I/IV interface [polypeptide binding]; other site 272624007770 Subunit I/II interface [polypeptide binding]; other site 272624007771 Low-spin heme (heme a) binding site [chemical binding]; other site 272624007772 Subunit I/VIIa interface [polypeptide binding]; other site 272624007773 Subunit I/VIa interface [polypeptide binding]; other site 272624007774 Dimer interface; other site 272624007775 Putative water exit pathway; other site 272624007776 Binuclear center (heme a3/CuB) [ion binding]; other site 272624007777 K-pathway; other site 272624007778 Subunit I/Vb interface [polypeptide binding]; other site 272624007779 Putative proton exit pathway; other site 272624007780 Subunit I/VIb interface; other site 272624007781 Subunit I/VIc interface [polypeptide binding]; other site 272624007782 Electron transfer pathway; other site 272624007783 Subunit I/VIIIb interface [polypeptide binding]; other site 272624007784 Subunit I/VIIb interface [polypeptide binding]; other site 272624007785 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 272624007786 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168 272624007787 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272624007788 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272624007789 Cytochrome c; Region: Cytochrom_C; pfam00034 272624007790 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272624007791 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 272624007792 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 272624007793 identified by homology, ferredoxin component, pseudogene 272624007794 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272624007795 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272624007796 Lysine efflux permease [General function prediction only]; Region: COG1279 272624007797 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 272624007798 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 272624007799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272624007800 S-adenosylmethionine binding site [chemical binding]; other site 272624007801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 272624007802 SCP-2 sterol transfer family; Region: SCP2; pfam02036 272624007803 SCP-2 sterol transfer family; Region: SCP2; cl01225 272624007804 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 272624007805 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272624007806 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 272624007807 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 272624007808 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 272624007809 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272624007810 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 272624007811 tyramine oxidase; Provisional; Region: tynA; PRK11504 272624007812 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 272624007813 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 272624007814 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 272624007815 Serine carboxypeptidase; Region: Peptidase_S10; pfam00450 272624007816 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272624007817 AAA domain; Region: AAA_14; pfam13173 272624007818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272624007819 non-specific DNA binding site [nucleotide binding]; other site 272624007820 salt bridge; other site 272624007821 sequence-specific DNA binding site [nucleotide binding]; other site 272624007822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272624007823 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272624007824 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272624007825 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272624007826 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272624007827 Beta-lactamase; Region: Beta-lactamase; pfam00144 272624007828 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 272624007829 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272624007830 active site 272624007831 NTP binding site [chemical binding]; other site 272624007832 metal binding triad [ion binding]; metal-binding site 272624007833 antibiotic binding site [chemical binding]; other site 272624007834 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272624007835 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272624007836 FtsX-like permease family; Region: FtsX; pfam02687 272624007837 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272624007838 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272624007839 Walker A/P-loop; other site 272624007840 ATP binding site [chemical binding]; other site 272624007841 Q-loop/lid; other site 272624007842 ABC transporter signature motif; other site 272624007843 Walker B; other site 272624007844 D-loop; other site 272624007845 H-loop/switch region; other site 272624007846 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272624007847 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272624007848 HlyD family secretion protein; Region: HlyD_3; pfam13437 272624007849 Outer membrane efflux protein; Region: OEP; pfam02321 272624007850 Outer membrane efflux protein; Region: OEP; pfam02321 272624007851 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 272624007852 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 272624007853 active site 272624007854 metal binding site [ion binding]; metal-binding site 272624007855 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 272624007856 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 272624007857 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272624007858 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 272624007859 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272624007860 tetramerization interface [polypeptide binding]; other site 272624007861 active site 272624007862 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 272624007863 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 272624007864 FMN reductase; Validated; Region: fre; PRK08051 272624007865 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 272624007866 FAD binding pocket [chemical binding]; other site 272624007867 FAD binding motif [chemical binding]; other site 272624007868 phosphate binding motif [ion binding]; other site 272624007869 beta-alpha-beta structure motif; other site 272624007870 NAD binding pocket [chemical binding]; other site 272624007871 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 272624007872 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272624007873 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 272624007874 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272624007875 RNA binding site [nucleotide binding]; other site 272624007876 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272624007877 multimer interface [polypeptide binding]; other site 272624007878 Walker A motif; other site 272624007879 ATP binding site [chemical binding]; other site 272624007880 Walker B motif; other site 272624007881 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272624007882 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272624007883 catalytic residues [active] 272624007884 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 272624007885 RNA methyltransferase, RsmE family; Region: TIGR00046 272624007886 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272624007887 Class II fumarases; Region: Fumarase_classII; cd01362 272624007888 active site 272624007889 tetramer interface [polypeptide binding]; other site 272624007890 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 272624007891 BNR repeat-like domain; Region: BNR_2; pfam13088 272624007892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272624007893 putative acyl-acceptor binding pocket; other site 272624007894 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272624007895 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272624007896 putative acyl-acceptor binding pocket; other site 272624007897 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 272624007898 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272624007899 active site 272624007900 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272624007901 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272624007902 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272624007903 trimer interface [polypeptide binding]; other site 272624007904 active site 272624007905 UDP-GlcNAc binding site [chemical binding]; other site 272624007906 lipid binding site [chemical binding]; lipid-binding site 272624007907 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272624007908 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272624007909 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 272624007910 active site 272624007911 nucleotide-binding site [chemical binding]; other site 272624007912 metal-binding site [ion binding] 272624007913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272624007914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272624007915 Walker A/P-loop; other site 272624007916 ATP binding site [chemical binding]; other site 272624007917 Q-loop/lid; other site 272624007918 ABC transporter signature motif; other site 272624007919 Walker B; other site 272624007920 D-loop; other site 272624007921 H-loop/switch region; other site 272624007922 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 272624007923 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 272624007924 active site 272624007925 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272624007926 Ligand Binding Site [chemical binding]; other site 272624007927 Molecular Tunnel; other site 272624007928 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272624007929 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272624007930 dimer interface [polypeptide binding]; other site 272624007931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624007932 catalytic residue [active] 272624007933 Histone methylation protein DOT1; Region: DOT1; pfam08123 272624007934 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272624007935 IHF dimer interface [polypeptide binding]; other site 272624007936 IHF - DNA interface [nucleotide binding]; other site 272624007937 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272624007938 trimer interface [polypeptide binding]; other site 272624007939 active site 272624007940 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272624007941 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272624007942 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 272624007943 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 272624007944 dimer interface [polypeptide binding]; other site 272624007945 active site residues [active] 272624007946 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 272624007947 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 272624007948 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 272624007949 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 272624007950 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272624007951 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272624007952 ligand binding site [chemical binding]; other site 272624007953 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 272624007954 active site 272624007955 substrate binding pocket [chemical binding]; other site 272624007956 dimer interface [polypeptide binding]; other site 272624007957 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272624007958 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 272624007959 dimer interface [polypeptide binding]; other site 272624007960 catalytic site [active] 272624007961 putative active site [active] 272624007962 putative substrate binding site [chemical binding]; other site 272624007963 peroxidase; Provisional; Region: PRK15000 272624007964 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272624007965 dimer interface [polypeptide binding]; other site 272624007966 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272624007967 catalytic triad [active] 272624007968 peroxidatic and resolving cysteines [active] 272624007969 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272624007970 putative GSH binding site [chemical binding]; other site 272624007971 catalytic residues [active] 272624007972 superoxide dismutase; Provisional; Region: PRK10543 272624007973 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272624007974 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272624007975 acetylornithine aminotransferase; Provisional; Region: PRK02627 272624007976 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272624007977 inhibitor-cofactor binding pocket; inhibition site 272624007978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272624007979 catalytic residue [active] 272624007980 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272624007981 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272624007982 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272624007983 active site 272624007984 catalytic site [active] 272624007985 malate dehydrogenase; Provisional; Region: PRK13529 272624007986 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272624007987 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272624007988 NAD(P) binding site [chemical binding]; other site 272624007989 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272624007990 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272624007991 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 272624007992 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272624007993 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 272624007994 active site 272624007995 Zn binding site [ion binding]; other site 272624007996 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 272624007997 Rossmann-like domain; Region: Rossmann-like; pfam10727 272624007998 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 272624007999 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272624008000 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272624008001 CAP-like domain; other site 272624008002 active site 272624008003 primary dimer interface [polypeptide binding]; other site 272624008004 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272624008005 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272624008006 gamma subunit interface [polypeptide binding]; other site 272624008007 LBP interface [polypeptide binding]; other site 272624008008 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272624008009 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272624008010 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272624008011 alpha subunit interaction interface [polypeptide binding]; other site 272624008012 Walker A motif; other site 272624008013 ATP binding site [chemical binding]; other site 272624008014 Walker B motif; other site 272624008015 inhibitor binding site; inhibition site 272624008016 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272624008017 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272624008018 core domain interface [polypeptide binding]; other site 272624008019 delta subunit interface [polypeptide binding]; other site 272624008020 epsilon subunit interface [polypeptide binding]; other site 272624008021 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272624008022 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272624008023 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272624008024 beta subunit interaction interface [polypeptide binding]; other site 272624008025 Walker A motif; other site 272624008026 ATP binding site [chemical binding]; other site 272624008027 Walker B motif; other site 272624008028 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272624008029 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272624008030 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272624008031 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272624008032 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272624008033 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 272624008034 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272624008035 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272624008036 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 272624008037 outer membrane lipoprotein; Provisional; Region: PRK11023 272624008038 BON domain; Region: BON; pfam04972 272624008039 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 272624008040 BON domain; Region: BON; pfam04972 272624008041 BON domain; Region: BON; cl02771 272624008042 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 272624008043 dimer interface [polypeptide binding]; other site 272624008044 active site 272624008045 hypothetical protein; Reviewed; Region: PRK12497 272624008046 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 272624008047 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 272624008048 putative ligand binding site [chemical binding]; other site 272624008049 Predicted methyltransferases [General function prediction only]; Region: COG0313 272624008050 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272624008051 putative SAM binding site [chemical binding]; other site 272624008052 putative homodimer interface [polypeptide binding]; other site 272624008053 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 272624008054 Fatty acid desaturase; Region: FA_desaturase; pfam00487 272624008055 Di-iron ligands [ion binding]; other site 272624008056 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272624008057 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272624008058 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272624008059 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272624008060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272624008061 ligand binding site [chemical binding]; other site 272624008062 flexible hinge region; other site 272624008063 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 272624008064 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 272624008065 active site 272624008066 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272624008067 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272624008068 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 272624008069 GTP/Mg2+ binding site [chemical binding]; other site 272624008070 G4 box; other site 272624008071 G5 box; other site 272624008072 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272624008073 G1 box; other site 272624008074 G1 box; other site 272624008075 GTP/Mg2+ binding site [chemical binding]; other site 272624008076 Switch I region; other site 272624008077 Switch I region; other site 272624008078 G2 box; other site 272624008079 G2 box; other site 272624008080 Switch II region; other site 272624008081 G3 box; other site 272624008082 G4 box; other site 272624008083 G5 box; other site 272624008084 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272624008085 membrane protein insertase; Provisional; Region: PRK01318 272624008086 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272624008087 hypothetical protein; Provisional; Region: PRK14380 272624008088 Ribonuclease P; Region: Ribonuclease_P; cl00457 272624008089 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399