-- dump date 20140619_130641 -- class Genbank::misc_feature -- table misc_feature_note -- id note 91891000001 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 91891000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 91891000003 DnaA N-terminal domain; Region: DnaA_N; pfam11638 91891000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891000005 Walker A motif; other site 91891000006 ATP binding site [chemical binding]; other site 91891000007 Walker B motif; other site 91891000008 arginine finger; other site 91891000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 91891000010 DnaA box-binding interface [nucleotide binding]; other site 91891000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 91891000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 91891000013 putative DNA binding surface [nucleotide binding]; other site 91891000014 dimer interface [polypeptide binding]; other site 91891000015 beta-clamp/clamp loader binding surface; other site 91891000016 beta-clamp/translesion DNA polymerase binding surface; other site 91891000017 recombination protein F; Reviewed; Region: recF; PRK00064 91891000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891000019 Walker A/P-loop; other site 91891000020 ATP binding site [chemical binding]; other site 91891000021 Q-loop/lid; other site 91891000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891000023 ABC transporter signature motif; other site 91891000024 Walker B; other site 91891000025 D-loop; other site 91891000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 91891000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891000028 Mg2+ binding site [ion binding]; other site 91891000029 G-X-G motif; other site 91891000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 91891000031 anchoring element; other site 91891000032 dimer interface [polypeptide binding]; other site 91891000033 ATP binding site [chemical binding]; other site 91891000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 91891000035 active site 91891000036 putative metal-binding site [ion binding]; other site 91891000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 91891000038 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 91891000039 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 91891000040 arginine decarboxylase; Provisional; Region: PRK05354 91891000041 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 91891000042 dimer interface [polypeptide binding]; other site 91891000043 active site 91891000044 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 91891000045 catalytic residues [active] 91891000046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 91891000047 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 91891000048 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 91891000049 putative active site; other site 91891000050 catalytic triad [active] 91891000051 putative dimer interface [polypeptide binding]; other site 91891000052 bacterial Hfq-like; Region: Hfq; cd01716 91891000053 hexamer interface [polypeptide binding]; other site 91891000054 Sm1 motif; other site 91891000055 RNA binding site [nucleotide binding]; other site 91891000056 Sm2 motif; other site 91891000057 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 91891000058 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 91891000059 HflX GTPase family; Region: HflX; cd01878 91891000060 G1 box; other site 91891000061 GTP/Mg2+ binding site [chemical binding]; other site 91891000062 Switch I region; other site 91891000063 G2 box; other site 91891000064 G3 box; other site 91891000065 Switch II region; other site 91891000066 G4 box; other site 91891000067 G5 box; other site 91891000068 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 91891000069 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 91891000070 catalytic residues [active] 91891000071 Pirin-related protein [General function prediction only]; Region: COG1741 91891000072 Pirin; Region: Pirin; pfam02678 91891000073 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 91891000074 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 91891000075 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 91891000076 active site 91891000077 nucleophile elbow; other site 91891000078 Patatin phospholipase; Region: DUF3734; pfam12536 91891000079 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 91891000080 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891000081 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891000082 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 91891000083 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 91891000084 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 91891000085 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 91891000086 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 91891000087 active site 91891000088 Zn binding site [ion binding]; other site 91891000089 hypothetical protein; Provisional; Region: PRK05255 91891000090 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 91891000091 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 91891000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891000093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891000094 Protein of unknown function (DUF962); Region: DUF962; cl01879 91891000095 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 91891000096 amino acid transporter; Region: 2A0306; TIGR00909 91891000097 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 91891000098 Phosphate transporter family; Region: PHO4; pfam01384 91891000099 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 91891000100 diiron binding motif [ion binding]; other site 91891000101 PAS domain; Region: PAS_9; pfam13426 91891000102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891000103 putative active site [active] 91891000104 heme pocket [chemical binding]; other site 91891000105 PAS domain S-box; Region: sensory_box; TIGR00229 91891000106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891000107 putative active site [active] 91891000108 heme pocket [chemical binding]; other site 91891000109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891000110 PAS domain; Region: PAS_9; pfam13426 91891000111 putative active site [active] 91891000112 heme pocket [chemical binding]; other site 91891000113 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891000114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891000115 metal binding site [ion binding]; metal-binding site 91891000116 active site 91891000117 I-site; other site 91891000118 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891000119 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 91891000120 Peptidase family M28; Region: Peptidase_M28; pfam04389 91891000121 active site 91891000122 metal binding site [ion binding]; metal-binding site 91891000123 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 91891000124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891000125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891000126 substrate binding pocket [chemical binding]; other site 91891000127 membrane-bound complex binding site; other site 91891000128 hinge residues; other site 91891000129 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891000130 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891000131 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 91891000132 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 91891000133 active site 91891000134 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 91891000135 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 91891000136 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 91891000137 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 91891000138 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 91891000139 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 91891000140 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 91891000141 trimer interface [polypeptide binding]; other site 91891000142 active site 91891000143 substrate binding site [chemical binding]; other site 91891000144 CoA binding site [chemical binding]; other site 91891000145 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 91891000146 amino acid transporter; Region: 2A0306; TIGR00909 91891000147 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 91891000148 Predicted membrane protein [Function unknown]; Region: COG2323 91891000149 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 91891000150 tetramer interface [polypeptide binding]; other site 91891000151 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 91891000152 active site 91891000153 Mg2+/Mn2+ binding site [ion binding]; other site 91891000154 Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981 91891000155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891000156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891000157 LysR substrate binding domain; Region: LysR_substrate; pfam03466 91891000158 dimerization interface [polypeptide binding]; other site 91891000159 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 91891000160 putative active site [active] 91891000161 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 91891000162 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 91891000163 DNA binding residues [nucleotide binding] 91891000164 dimer interface [polypeptide binding]; other site 91891000165 mercury binding site [ion binding]; other site 91891000166 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 91891000167 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891000168 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891000169 Transposase; Region: HTH_Tnp_1; pfam01527 91891000170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 91891000171 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 91891000172 active site 91891000173 SAM binding site [chemical binding]; other site 91891000174 homodimer interface [polypeptide binding]; other site 91891000175 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891000176 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 91891000177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891000178 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 91891000179 Serine hydrolase; Region: Ser_hydrolase; cl17834 91891000180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891000181 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 91891000182 EamA-like transporter family; Region: EamA; pfam00892 91891000183 EamA-like transporter family; Region: EamA; pfam00892 91891000184 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891000185 aspartate aminotransferase; Provisional; Region: PRK05764 91891000186 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 91891000187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891000188 homodimer interface [polypeptide binding]; other site 91891000189 catalytic residue [active] 91891000190 excinuclease ABC subunit B; Provisional; Region: PRK05298 91891000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891000192 ATP binding site [chemical binding]; other site 91891000193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891000194 nucleotide binding region [chemical binding]; other site 91891000195 ATP-binding site [chemical binding]; other site 91891000196 Ultra-violet resistance protein B; Region: UvrB; pfam12344 91891000197 UvrB/uvrC motif; Region: UVR; pfam02151 91891000198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891000199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891000200 metal binding site [ion binding]; metal-binding site 91891000201 active site 91891000202 I-site; other site 91891000203 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891000204 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 91891000205 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 91891000206 active site 91891000207 FMN binding site [chemical binding]; other site 91891000208 substrate binding site [chemical binding]; other site 91891000209 3Fe-4S cluster binding site [ion binding]; other site 91891000210 Cell division protein ZapA; Region: ZapA; pfam05164 91891000211 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 91891000212 proline aminopeptidase P II; Provisional; Region: PRK10879 91891000213 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 91891000214 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 91891000215 active site 91891000216 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 91891000217 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 91891000218 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 91891000219 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 91891000220 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 91891000221 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 91891000222 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 91891000223 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 91891000224 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 91891000225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891000226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891000227 substrate binding pocket [chemical binding]; other site 91891000228 membrane-bound complex binding site; other site 91891000229 hinge residues; other site 91891000230 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 91891000231 ribonuclease R; Region: RNase_R; TIGR02063 91891000232 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 91891000233 RNB domain; Region: RNB; pfam00773 91891000234 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 91891000235 RNA binding site [nucleotide binding]; other site 91891000236 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 91891000237 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 91891000238 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 91891000239 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 91891000240 tetramer (dimer of dimers) interface [polypeptide binding]; other site 91891000241 active site 91891000242 dimer interface [polypeptide binding]; other site 91891000243 5' nucleotidase family; Region: 5_nucleotid; cl17687 91891000244 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 91891000245 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 91891000246 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 91891000247 PhnA protein; Region: PhnA; pfam03831 91891000248 Response regulator receiver domain; Region: Response_reg; pfam00072 91891000249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891000250 active site 91891000251 phosphorylation site [posttranslational modification] 91891000252 intermolecular recognition site; other site 91891000253 DNA polymerase I; Provisional; Region: PRK05755 91891000254 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 91891000255 active site 91891000256 metal binding site 1 [ion binding]; metal-binding site 91891000257 putative 5' ssDNA interaction site; other site 91891000258 metal binding site 3; metal-binding site 91891000259 metal binding site 2 [ion binding]; metal-binding site 91891000260 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 91891000261 putative DNA binding site [nucleotide binding]; other site 91891000262 putative metal binding site [ion binding]; other site 91891000263 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 91891000264 active site 91891000265 catalytic site [active] 91891000266 substrate binding site [chemical binding]; other site 91891000267 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 91891000268 active site 91891000269 DNA binding site [nucleotide binding] 91891000270 catalytic site [active] 91891000271 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 91891000272 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 91891000273 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 91891000274 trimer interface [polypeptide binding]; other site 91891000275 active site 91891000276 UDP-GlcNAc binding site [chemical binding]; other site 91891000277 lipid binding site [chemical binding]; lipid-binding site 91891000278 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 91891000279 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 91891000280 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 91891000281 dimer interface [polypeptide binding]; other site 91891000282 active site 91891000283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891000284 Coenzyme A binding pocket [chemical binding]; other site 91891000285 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 91891000286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891000287 Coenzyme A binding pocket [chemical binding]; other site 91891000288 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 91891000289 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 91891000290 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 91891000291 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 91891000292 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 91891000293 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 91891000294 substrate binding pocket [chemical binding]; other site 91891000295 substrate-Mg2+ binding site; other site 91891000296 aspartate-rich region 1; other site 91891000297 aspartate-rich region 2; other site 91891000298 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891000299 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 91891000300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891000301 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 91891000302 tetramer interface [polypeptide binding]; other site 91891000303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891000304 catalytic residue [active] 91891000305 YCII-related domain; Region: YCII; cl00999 91891000306 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 91891000307 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 91891000308 tetramer interface [polypeptide binding]; other site 91891000309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891000310 catalytic residue [active] 91891000311 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 91891000312 lipoyl attachment site [posttranslational modification]; other site 91891000313 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 91891000314 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 91891000315 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 91891000316 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891000317 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 91891000318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891000319 dimer interface [polypeptide binding]; other site 91891000320 conserved gate region; other site 91891000321 putative PBP binding loops; other site 91891000322 ABC-ATPase subunit interface; other site 91891000323 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 91891000324 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 91891000325 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 91891000326 Walker A/P-loop; other site 91891000327 ATP binding site [chemical binding]; other site 91891000328 Q-loop/lid; other site 91891000329 ABC transporter signature motif; other site 91891000330 Walker B; other site 91891000331 D-loop; other site 91891000332 H-loop/switch region; other site 91891000333 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 91891000334 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 91891000335 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 91891000336 catalytic residues [active] 91891000337 hinge region; other site 91891000338 alpha helical domain; other site 91891000339 Cytochrome c553 [Energy production and conversion]; Region: COG2863 91891000340 Cytochrome c; Region: Cytochrom_C; cl11414 91891000341 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 91891000342 G1 box; other site 91891000343 GTP/Mg2+ binding site [chemical binding]; other site 91891000344 Switch I region; other site 91891000345 G2 box; other site 91891000346 G3 box; other site 91891000347 Switch II region; other site 91891000348 G4 box; other site 91891000349 G5 box; other site 91891000350 acetyl-CoA synthetase; Provisional; Region: PRK00174 91891000351 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 91891000352 active site 91891000353 CoA binding site [chemical binding]; other site 91891000354 acyl-activating enzyme (AAE) consensus motif; other site 91891000355 AMP binding site [chemical binding]; other site 91891000356 acetate binding site [chemical binding]; other site 91891000357 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 91891000358 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 91891000359 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 91891000360 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 91891000361 tetrameric interface [polypeptide binding]; other site 91891000362 NAD binding site [chemical binding]; other site 91891000363 catalytic residues [active] 91891000364 Dodecin; Region: Dodecin; cl01328 91891000365 dihydrodipicolinate reductase; Provisional; Region: PRK00048 91891000366 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 91891000367 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 91891000368 ProQ/FINO family; Region: ProQ; pfam04352 91891000369 pyruvate kinase; Provisional; Region: PRK05826 91891000370 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 91891000371 domain interfaces; other site 91891000372 active site 91891000373 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 91891000374 Phosphoglycerate kinase; Region: PGK; pfam00162 91891000375 substrate binding site [chemical binding]; other site 91891000376 hinge regions; other site 91891000377 ADP binding site [chemical binding]; other site 91891000378 catalytic site [active] 91891000379 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 91891000380 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 91891000381 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 91891000382 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 91891000383 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 91891000384 TPP-binding site [chemical binding]; other site 91891000385 dimer interface [polypeptide binding]; other site 91891000386 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 91891000387 PYR/PP interface [polypeptide binding]; other site 91891000388 dimer interface [polypeptide binding]; other site 91891000389 TPP binding site [chemical binding]; other site 91891000390 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 91891000391 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 91891000392 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 91891000393 active site 91891000394 Zn binding site [ion binding]; other site 91891000395 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 91891000396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891000397 Soluble P-type ATPase [General function prediction only]; Region: COG4087 91891000398 Domain of unknown function DUF302; Region: DUF302; pfam03625 91891000399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891000400 sequence-specific DNA binding site [nucleotide binding]; other site 91891000401 salt bridge; other site 91891000402 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 91891000403 Catalytic site [active] 91891000404 Global regulator protein family; Region: CsrA; pfam02599 91891000405 TrbC/VIRB2 family; Region: TrbC; pfam04956 91891000406 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 91891000407 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 91891000408 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 91891000409 Type IV secretion system proteins; Region: T4SS; pfam07996 91891000410 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 91891000411 VirB8 protein; Region: VirB8; pfam04335 91891000412 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 91891000413 VirB7 interaction site; other site 91891000414 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 91891000415 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 91891000416 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 91891000417 Walker A motif; other site 91891000418 hexamer interface [polypeptide binding]; other site 91891000419 ATP binding site [chemical binding]; other site 91891000420 Walker B motif; other site 91891000421 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 91891000422 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891000423 Walker A motif; other site 91891000424 ATP binding site [chemical binding]; other site 91891000425 Walker B motif; other site 91891000426 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 91891000427 MobA/MobL family; Region: MobA_MobL; pfam03389 91891000428 AAA domain; Region: AAA_30; pfam13604 91891000429 Family description; Region: UvrD_C_2; pfam13538 91891000430 Conjugal transfer protein TraD; Region: TraD; pfam06412 91891000431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891000432 S-adenosylmethionine binding site [chemical binding]; other site 91891000433 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 91891000434 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 91891000435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891000436 non-specific DNA binding site [nucleotide binding]; other site 91891000437 salt bridge; other site 91891000438 sequence-specific DNA binding site [nucleotide binding]; other site 91891000439 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 91891000440 Catalytic site [active] 91891000441 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 91891000442 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 91891000443 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 91891000444 Int/Topo IB signature motif; other site 91891000445 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 91891000446 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 91891000447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891000448 non-specific DNA binding site [nucleotide binding]; other site 91891000449 salt bridge; other site 91891000450 sequence-specific DNA binding site [nucleotide binding]; other site 91891000451 Domain of unknown function (DUF955); Region: DUF955; cl01076 91891000452 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 91891000453 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 91891000454 putative transposase OrfB; Reviewed; Region: PHA02517 91891000455 HTH-like domain; Region: HTH_21; pfam13276 91891000456 Integrase core domain; Region: rve; pfam00665 91891000457 Integrase core domain; Region: rve_2; pfam13333 91891000458 Transposase; Region: HTH_Tnp_1; pfam01527 91891000459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 91891000460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 91891000461 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 91891000462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891000463 Coenzyme A binding pocket [chemical binding]; other site 91891000464 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 91891000465 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 91891000466 potential catalytic triad [active] 91891000467 conserved cys residue [active] 91891000468 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891000469 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891000470 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 91891000471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891000472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891000473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 91891000474 dimerization interface [polypeptide binding]; other site 91891000475 DNA binding residues [nucleotide binding] 91891000476 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 91891000477 Ubiquitin-like proteins; Region: UBQ; cl00155 91891000478 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 91891000479 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 91891000480 ATP binding site [chemical binding]; other site 91891000481 substrate interface [chemical binding]; other site 91891000482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 91891000483 active site residue [active] 91891000484 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 91891000485 YcaO-like family; Region: YcaO; pfam02624 91891000486 TfuA-like protein; Region: TfuA; pfam07812 91891000487 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891000488 Uncharacterized conserved protein [Function unknown]; Region: COG4278 91891000489 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 91891000490 active site 91891000491 iron coordination sites [ion binding]; other site 91891000492 substrate binding pocket [chemical binding]; other site 91891000493 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 91891000494 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 91891000495 Transposase; Region: HTH_Tnp_1; pfam01527 91891000496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 91891000497 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 91891000498 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 91891000499 putative active site [active] 91891000500 putative NTP binding site [chemical binding]; other site 91891000501 putative nucleic acid binding site [nucleotide binding]; other site 91891000502 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 91891000503 putative transposase OrfB; Reviewed; Region: PHA02517 91891000504 HTH-like domain; Region: HTH_21; pfam13276 91891000505 Integrase core domain; Region: rve; pfam00665 91891000506 Integrase core domain; Region: rve_3; pfam13683 91891000507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891000508 Coenzyme A binding pocket [chemical binding]; other site 91891000509 PAS domain; Region: PAS_9; pfam13426 91891000510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891000511 putative active site [active] 91891000512 heme pocket [chemical binding]; other site 91891000513 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891000514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891000515 metal binding site [ion binding]; metal-binding site 91891000516 active site 91891000517 I-site; other site 91891000518 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 91891000519 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 91891000520 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 91891000521 active site 91891000522 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 91891000523 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 91891000524 Uncharacterized conserved protein [Function unknown]; Region: COG0432 91891000525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891000526 Acyl transferase domain; Region: Acyl_transf_1; cl08282 91891000527 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 91891000528 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 91891000529 Protein of unknown function (DUF808); Region: DUF808; pfam05661 91891000530 RF-1 domain; Region: RF-1; pfam00472 91891000531 Protein of unknown function (DUF330); Region: DUF330; pfam03886 91891000532 mce related protein; Region: MCE; pfam02470 91891000533 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 91891000534 Permease; Region: Permease; pfam02405 91891000535 F-box-like; Region: F-box-like; pfam12937 91891000536 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891000537 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891000538 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 91891000539 dimerization interface [polypeptide binding]; other site 91891000540 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 91891000541 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 91891000542 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 91891000543 substrate binding pocket [chemical binding]; other site 91891000544 active site 91891000545 iron coordination sites [ion binding]; other site 91891000546 hypothetical protein; Provisional; Region: PRK07190 91891000547 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 91891000548 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 91891000549 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 91891000550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891000551 putative substrate translocation pore; other site 91891000552 hypothetical protein; Provisional; Region: PRK07206 91891000553 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 91891000554 Methyltransferase domain; Region: Methyltransf_31; pfam13847 91891000555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891000556 S-adenosylmethionine binding site [chemical binding]; other site 91891000557 M48 family peptidase; Provisional; Region: PRK03001 91891000558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 91891000559 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 91891000560 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 91891000561 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 91891000562 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 91891000563 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 91891000564 Walker A/P-loop; other site 91891000565 ATP binding site [chemical binding]; other site 91891000566 Q-loop/lid; other site 91891000567 ABC transporter signature motif; other site 91891000568 Walker B; other site 91891000569 D-loop; other site 91891000570 H-loop/switch region; other site 91891000571 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 91891000572 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 91891000573 TM-ABC transporter signature motif; other site 91891000574 hypothetical protein; Provisional; Region: PRK09133 91891000575 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 91891000576 putative metal binding site [ion binding]; other site 91891000577 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 91891000578 CoA-transferase family III; Region: CoA_transf_3; pfam02515 91891000579 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 91891000580 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 91891000581 putative dimer interface [polypeptide binding]; other site 91891000582 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 91891000583 dimer interface [polypeptide binding]; other site 91891000584 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 91891000585 active site 91891000586 heme binding site [chemical binding]; other site 91891000587 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 91891000588 Uncharacterized conserved protein [Function unknown]; Region: COG0393 91891000589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 91891000590 Chitin binding domain; Region: Chitin_bind_3; pfam03067 91891000591 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 91891000592 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 91891000593 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 91891000594 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 91891000595 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 91891000596 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 91891000597 DAK2 domain; Region: Dak2; pfam02734 91891000598 EDD domain protein, DegV family; Region: DegV; TIGR00762 91891000599 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 91891000600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 91891000601 classical (c) SDRs; Region: SDR_c; cd05233 91891000602 NAD(P) binding site [chemical binding]; other site 91891000603 active site 91891000604 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 91891000605 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 91891000606 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 91891000607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 91891000608 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 91891000609 active site 91891000610 ATP binding site [chemical binding]; other site 91891000611 substrate binding site [chemical binding]; other site 91891000612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 91891000613 substrate binding site [chemical binding]; other site 91891000614 activation loop (A-loop); other site 91891000615 activation loop (A-loop); other site 91891000616 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 91891000617 TspO/MBR family; Region: TspO_MBR; pfam03073 91891000618 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 91891000619 DNA photolyase; Region: DNA_photolyase; pfam00875 91891000620 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 91891000621 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 91891000622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891000623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891000624 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 91891000625 putative dimerization interface [polypeptide binding]; other site 91891000626 Domain of unknown function (DUF329); Region: DUF329; pfam03884 91891000627 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 91891000628 ATP-grasp domain; Region: ATP-grasp; pfam02222 91891000629 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 91891000630 Nitrogen regulatory protein P-II; Region: P-II; cl00412 91891000631 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 91891000632 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 91891000633 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 91891000634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891000635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891000636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 91891000637 dimerization interface [polypeptide binding]; other site 91891000638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891000639 ATP binding site [chemical binding]; other site 91891000640 Q-loop/lid; other site 91891000641 ABC transporter signature motif; other site 91891000642 Walker B; other site 91891000643 D-loop; other site 91891000644 H-loop/switch region; other site 91891000645 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 91891000646 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891000647 Outer membrane efflux protein; Region: OEP; pfam02321 91891000648 Outer membrane efflux protein; Region: OEP; pfam02321 91891000649 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 91891000650 hypothetical protein; Provisional; Region: PHA02764 91891000651 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 91891000652 heme ligand [chemical binding]; other site 91891000653 CHASE3 domain; Region: CHASE3; pfam05227 91891000654 PAS fold; Region: PAS_4; pfam08448 91891000655 GAF domain; Region: GAF_3; pfam13492 91891000656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891000657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891000658 metal binding site [ion binding]; metal-binding site 91891000659 active site 91891000660 I-site; other site 91891000661 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 91891000662 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891000663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891000664 motif II; other site 91891000665 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 91891000666 metal binding site 2 [ion binding]; metal-binding site 91891000667 putative DNA binding helix; other site 91891000668 metal binding site 1 [ion binding]; metal-binding site 91891000669 dimer interface [polypeptide binding]; other site 91891000670 structural Zn2+ binding site [ion binding]; other site 91891000671 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 91891000672 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 91891000673 PYR/PP interface [polypeptide binding]; other site 91891000674 dimer interface [polypeptide binding]; other site 91891000675 TPP binding site [chemical binding]; other site 91891000676 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 91891000677 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 91891000678 TPP-binding site [chemical binding]; other site 91891000679 dimer interface [polypeptide binding]; other site 91891000680 Dot/Icm substrate protein; Region: SidE; pfam12252 91891000681 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 91891000682 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 91891000683 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 91891000684 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 91891000685 tetramerization interface [polypeptide binding]; other site 91891000686 NAD(P) binding site [chemical binding]; other site 91891000687 catalytic residues [active] 91891000688 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 91891000689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 91891000690 inhibitor-cofactor binding pocket; inhibition site 91891000691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891000692 catalytic residue [active] 91891000693 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 91891000694 glutaminase A; Region: Gln_ase; TIGR03814 91891000695 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 91891000696 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 91891000697 NAD binding site [chemical binding]; other site 91891000698 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 91891000699 putative NAD(P) binding site [chemical binding]; other site 91891000700 homodimer interface [polypeptide binding]; other site 91891000701 mercuric reductase; Validated; Region: PRK06370 91891000702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 91891000703 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 91891000704 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 91891000705 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 91891000706 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 91891000707 ArsC family; Region: ArsC; pfam03960 91891000708 catalytic residues [active] 91891000709 Fatty acid desaturase; Region: FA_desaturase; pfam00487 91891000710 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 91891000711 Di-iron ligands [ion binding]; other site 91891000712 Transposase; Region: DDE_Tnp_ISL3; pfam01610 91891000713 helicase 45; Provisional; Region: PTZ00424 91891000714 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 91891000715 ATP binding site [chemical binding]; other site 91891000716 Mg++ binding site [ion binding]; other site 91891000717 motif III; other site 91891000718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891000719 nucleotide binding region [chemical binding]; other site 91891000720 ATP-binding site [chemical binding]; other site 91891000721 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 91891000722 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 91891000723 hypothetical protein; Provisional; Region: PRK11212 91891000724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 91891000725 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 91891000726 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 91891000727 HlyD family secretion protein; Region: HlyD; pfam00529 91891000728 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891000729 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891000730 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 91891000731 GIY-YIG motif/motif A; other site 91891000732 putative active site [active] 91891000733 putative metal binding site [ion binding]; other site 91891000734 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 91891000735 Fe-S cluster binding site [ion binding]; other site 91891000736 active site 91891000737 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 91891000738 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 91891000739 amidase catalytic site [active] 91891000740 Zn binding residues [ion binding]; other site 91891000741 substrate binding site [chemical binding]; other site 91891000742 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 91891000743 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 91891000744 Multicopper oxidase; Region: Cu-oxidase; pfam00394 91891000745 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 91891000746 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 91891000747 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 91891000748 oligomer interface [polypeptide binding]; other site 91891000749 metal binding site [ion binding]; metal-binding site 91891000750 metal binding site [ion binding]; metal-binding site 91891000751 putative Cl binding site [ion binding]; other site 91891000752 aspartate ring; other site 91891000753 hydrophobic gate; other site 91891000754 basic sphincter; other site 91891000755 periplasmic entrance; other site 91891000756 HD domain; Region: HD_3; pfam13023 91891000757 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 91891000758 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 91891000759 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 91891000760 active site 91891000761 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 91891000762 Isochorismatase family; Region: Isochorismatase; pfam00857 91891000763 catalytic triad [active] 91891000764 metal binding site [ion binding]; metal-binding site 91891000765 conserved cis-peptide bond; other site 91891000766 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 91891000767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 91891000768 metal binding site [ion binding]; metal-binding site 91891000769 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 91891000770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891000771 putative substrate translocation pore; other site 91891000772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891000773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891000774 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 91891000775 putative effector binding pocket; other site 91891000776 dimerization interface [polypeptide binding]; other site 91891000777 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 91891000778 Ras interaction site [polypeptide binding]; other site 91891000779 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 91891000780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891000781 active site 91891000782 phosphorylation site [posttranslational modification] 91891000783 intermolecular recognition site; other site 91891000784 dimerization interface [polypeptide binding]; other site 91891000785 PAS domain; Region: PAS; smart00091 91891000786 PAS fold; Region: PAS_7; pfam12860 91891000787 putative active site [active] 91891000788 heme pocket [chemical binding]; other site 91891000789 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891000790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891000791 metal binding site [ion binding]; metal-binding site 91891000792 active site 91891000793 I-site; other site 91891000794 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891000795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891000796 putative active site [active] 91891000797 heme pocket [chemical binding]; other site 91891000798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891000799 ATP binding site [chemical binding]; other site 91891000800 Mg2+ binding site [ion binding]; other site 91891000801 G-X-G motif; other site 91891000802 FIST N domain; Region: FIST; pfam08495 91891000803 Uncharacterized conserved protein [Function unknown]; Region: COG3287 91891000804 FIST C domain; Region: FIST_C; pfam10442 91891000805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891000806 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 91891000807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 91891000808 dimerization interface [polypeptide binding]; other site 91891000809 amino acid transporter; Region: 2A0306; TIGR00909 91891000810 hypothetical protein; Provisional; Region: PRK08317 91891000811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891000812 S-adenosylmethionine binding site [chemical binding]; other site 91891000813 formate dehydrogenase; Provisional; Region: PRK07574 91891000814 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 91891000815 dimerization interface [polypeptide binding]; other site 91891000816 ligand binding site [chemical binding]; other site 91891000817 NAD binding site [chemical binding]; other site 91891000818 catalytic site [active] 91891000819 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 91891000820 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 91891000821 putative NAD(P) binding site [chemical binding]; other site 91891000822 homodimer interface [polypeptide binding]; other site 91891000823 homotetramer interface [polypeptide binding]; other site 91891000824 active site 91891000825 elongation factor P; Validated; Region: PRK00529 91891000826 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 91891000827 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 91891000828 RNA binding site [nucleotide binding]; other site 91891000829 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 91891000830 RNA binding site [nucleotide binding]; other site 91891000831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 91891000832 Radical SAM superfamily; Region: Radical_SAM; pfam04055 91891000833 FeS/SAM binding site; other site 91891000834 polyphosphate kinase; Provisional; Region: PRK05443 91891000835 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 91891000836 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 91891000837 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 91891000838 putative active site [active] 91891000839 catalytic site [active] 91891000840 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 91891000841 putative domain interface [polypeptide binding]; other site 91891000842 putative active site [active] 91891000843 catalytic site [active] 91891000844 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 91891000845 nucleophile elbow; other site 91891000846 Chromate transporter; Region: Chromate_transp; pfam02417 91891000847 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 91891000848 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 91891000849 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 91891000850 active site 91891000851 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 91891000852 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 91891000853 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 91891000854 Substrate binding site; other site 91891000855 metal-binding site 91891000856 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 91891000857 Phosphotransferase enzyme family; Region: APH; pfam01636 91891000858 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 91891000859 OstA-like protein; Region: OstA; cl00844 91891000860 Organic solvent tolerance protein; Region: OstA_C; pfam04453 91891000861 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 91891000862 SurA N-terminal domain; Region: SurA_N; pfam09312 91891000863 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 91891000864 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 91891000865 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 91891000866 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 91891000867 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 91891000868 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 91891000869 folate binding site [chemical binding]; other site 91891000870 NADP+ binding site [chemical binding]; other site 91891000871 Repeats found in Drosophila proteins; Region: DM9; smart00696 91891000872 Protein of unknown function (DUF3421); Region: DUF3421; pfam11901 91891000873 Repeats found in Drosophila proteins; Region: DM9; smart00696 91891000874 elongation factor Tu; Reviewed; Region: PRK00049 91891000875 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 91891000876 G1 box; other site 91891000877 GEF interaction site [polypeptide binding]; other site 91891000878 GTP/Mg2+ binding site [chemical binding]; other site 91891000879 Switch I region; other site 91891000880 G2 box; other site 91891000881 G3 box; other site 91891000882 Switch II region; other site 91891000883 G4 box; other site 91891000884 G5 box; other site 91891000885 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 91891000886 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 91891000887 Antibiotic Binding Site [chemical binding]; other site 91891000888 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 91891000889 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 91891000890 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 91891000891 putative homodimer interface [polypeptide binding]; other site 91891000892 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 91891000893 heterodimer interface [polypeptide binding]; other site 91891000894 homodimer interface [polypeptide binding]; other site 91891000895 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 91891000896 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 91891000897 23S rRNA interface [nucleotide binding]; other site 91891000898 L7/L12 interface [polypeptide binding]; other site 91891000899 putative thiostrepton binding site; other site 91891000900 L25 interface [polypeptide binding]; other site 91891000901 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 91891000902 mRNA/rRNA interface [nucleotide binding]; other site 91891000903 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 91891000904 23S rRNA interface [nucleotide binding]; other site 91891000905 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 91891000906 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 91891000907 peripheral dimer interface [polypeptide binding]; other site 91891000908 core dimer interface [polypeptide binding]; other site 91891000909 L10 interface [polypeptide binding]; other site 91891000910 L11 interface [polypeptide binding]; other site 91891000911 putative EF-Tu interaction site [polypeptide binding]; other site 91891000912 putative EF-G interaction site [polypeptide binding]; other site 91891000913 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 91891000914 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 91891000915 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 91891000916 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 91891000917 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 91891000918 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 91891000919 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 91891000920 RPB3 interaction site [polypeptide binding]; other site 91891000921 RPB1 interaction site [polypeptide binding]; other site 91891000922 RPB11 interaction site [polypeptide binding]; other site 91891000923 RPB10 interaction site [polypeptide binding]; other site 91891000924 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 91891000925 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 91891000926 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 91891000927 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 91891000928 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 91891000929 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 91891000930 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 91891000931 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 91891000932 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 91891000933 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 91891000934 DNA binding site [nucleotide binding] 91891000935 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 91891000936 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 91891000937 S17 interaction site [polypeptide binding]; other site 91891000938 S8 interaction site; other site 91891000939 16S rRNA interaction site [nucleotide binding]; other site 91891000940 streptomycin interaction site [chemical binding]; other site 91891000941 23S rRNA interaction site [nucleotide binding]; other site 91891000942 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 91891000943 30S ribosomal protein S7; Validated; Region: PRK05302 91891000944 elongation factor G; Reviewed; Region: PRK00007 91891000945 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 91891000946 G1 box; other site 91891000947 putative GEF interaction site [polypeptide binding]; other site 91891000948 GTP/Mg2+ binding site [chemical binding]; other site 91891000949 Switch I region; other site 91891000950 G2 box; other site 91891000951 G3 box; other site 91891000952 Switch II region; other site 91891000953 G4 box; other site 91891000954 G5 box; other site 91891000955 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 91891000956 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 91891000957 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 91891000958 elongation factor Tu; Reviewed; Region: PRK00049 91891000959 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 91891000960 G1 box; other site 91891000961 GEF interaction site [polypeptide binding]; other site 91891000962 GTP/Mg2+ binding site [chemical binding]; other site 91891000963 Switch I region; other site 91891000964 G2 box; other site 91891000965 G3 box; other site 91891000966 Switch II region; other site 91891000967 G4 box; other site 91891000968 G5 box; other site 91891000969 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 91891000970 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 91891000971 Antibiotic Binding Site [chemical binding]; other site 91891000972 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 91891000973 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 91891000974 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 91891000975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 91891000976 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 91891000977 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 91891000978 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 91891000979 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 91891000980 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 91891000981 putative translocon binding site; other site 91891000982 protein-rRNA interface [nucleotide binding]; other site 91891000983 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 91891000984 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 91891000985 G-X-X-G motif; other site 91891000986 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 91891000987 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 91891000988 23S rRNA interface [nucleotide binding]; other site 91891000989 5S rRNA interface [nucleotide binding]; other site 91891000990 putative antibiotic binding site [chemical binding]; other site 91891000991 L25 interface [polypeptide binding]; other site 91891000992 L27 interface [polypeptide binding]; other site 91891000993 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 91891000994 putative translocon interaction site; other site 91891000995 23S rRNA interface [nucleotide binding]; other site 91891000996 signal recognition particle (SRP54) interaction site; other site 91891000997 L23 interface [polypeptide binding]; other site 91891000998 trigger factor interaction site; other site 91891000999 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 91891001000 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 91891001001 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 91891001002 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 91891001003 RNA binding site [nucleotide binding]; other site 91891001004 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 91891001005 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 91891001006 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 91891001007 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 91891001008 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 91891001009 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 91891001010 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 91891001011 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 91891001012 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 91891001013 23S rRNA interface [nucleotide binding]; other site 91891001014 L21e interface [polypeptide binding]; other site 91891001015 5S rRNA interface [nucleotide binding]; other site 91891001016 L27 interface [polypeptide binding]; other site 91891001017 L5 interface [polypeptide binding]; other site 91891001018 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 91891001019 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 91891001020 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 91891001021 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 91891001022 23S rRNA binding site [nucleotide binding]; other site 91891001023 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 91891001024 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 91891001025 SecY translocase; Region: SecY; pfam00344 91891001026 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 91891001027 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 91891001028 30S ribosomal protein S13; Region: bact_S13; TIGR03631 91891001029 30S ribosomal protein S11; Validated; Region: PRK05309 91891001030 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 91891001031 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 91891001032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 91891001033 RNA binding surface [nucleotide binding]; other site 91891001034 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 91891001035 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 91891001036 alphaNTD homodimer interface [polypeptide binding]; other site 91891001037 alphaNTD - beta interaction site [polypeptide binding]; other site 91891001038 alphaNTD - beta' interaction site [polypeptide binding]; other site 91891001039 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 91891001040 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 91891001041 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 91891001042 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 91891001043 dimer interface [polypeptide binding]; other site 91891001044 ssDNA binding site [nucleotide binding]; other site 91891001045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 91891001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891001048 putative substrate translocation pore; other site 91891001049 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 91891001050 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 91891001051 putative NAD(P) binding site [chemical binding]; other site 91891001052 active site 91891001053 Phosphopantetheine attachment site; Region: PP-binding; cl09936 91891001054 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 91891001055 active site 2 [active] 91891001056 active site 1 [active] 91891001057 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 91891001058 active site 2 [active] 91891001059 dimer interface [polypeptide binding]; other site 91891001060 active site 1 [active] 91891001061 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 91891001062 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 91891001063 dimer interface [polypeptide binding]; other site 91891001064 active site 91891001065 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 91891001066 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 91891001067 active site 91891001068 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 91891001069 putative acyl-acceptor binding pocket; other site 91891001070 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 91891001071 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 91891001072 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 91891001073 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 91891001074 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 91891001075 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 91891001076 putative coenzyme Q binding site [chemical binding]; other site 91891001077 hypothetical protein; Validated; Region: PRK01777 91891001078 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 91891001079 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 91891001080 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 91891001081 metal binding site 2 [ion binding]; metal-binding site 91891001082 putative DNA binding helix; other site 91891001083 metal binding site 1 [ion binding]; metal-binding site 91891001084 dimer interface [polypeptide binding]; other site 91891001085 structural Zn2+ binding site [ion binding]; other site 91891001086 Evidence 7 : Gene remnant; Product type e : enzyme 91891001087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891001088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891001089 metal binding site [ion binding]; metal-binding site 91891001090 active site 91891001091 I-site; other site 91891001092 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 91891001093 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 91891001094 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 91891001095 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 91891001096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 91891001097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 91891001098 CoenzymeA binding site [chemical binding]; other site 91891001099 subunit interaction site [polypeptide binding]; other site 91891001100 PHB binding site; other site 91891001101 BON domain; Region: BON; pfam04972 91891001102 BON domain; Region: BON; pfam04972 91891001103 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891001104 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 91891001105 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 91891001106 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 91891001107 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 91891001108 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 91891001109 heat shock protein HtpX; Provisional; Region: PRK02870 91891001110 inner membrane transport permease; Provisional; Region: PRK15066 91891001111 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 91891001112 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 91891001113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891001114 Walker A/P-loop; other site 91891001115 ATP binding site [chemical binding]; other site 91891001116 Q-loop/lid; other site 91891001117 ABC transporter signature motif; other site 91891001118 Walker B; other site 91891001119 D-loop; other site 91891001120 H-loop/switch region; other site 91891001121 hypothetical protein; Provisional; Region: PRK11281 91891001122 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 91891001123 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 91891001124 Protein of unknown function DUF45; Region: DUF45; pfam01863 91891001125 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 91891001126 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 91891001127 DNA binding site [nucleotide binding] 91891001128 active site 91891001129 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 91891001130 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 91891001131 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 91891001132 RimM N-terminal domain; Region: RimM; pfam01782 91891001133 PRC-barrel domain; Region: PRC; pfam05239 91891001134 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 91891001135 signal recognition particle protein; Provisional; Region: PRK10867 91891001136 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 91891001137 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 91891001138 P loop; other site 91891001139 GTP binding site [chemical binding]; other site 91891001140 Signal peptide binding domain; Region: SRP_SPB; pfam02978 91891001141 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891001143 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891001144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001145 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 91891001146 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 91891001147 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 91891001148 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 91891001149 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 91891001150 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 91891001151 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 91891001152 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 91891001153 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 91891001154 UbiA prenyltransferase family; Region: UbiA; pfam01040 91891001155 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 91891001156 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 91891001157 Cu(I) binding site [ion binding]; other site 91891001158 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 91891001159 RimK-like ATP-grasp domain; Region: RimK; pfam08443 91891001160 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 91891001161 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 91891001162 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 91891001163 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 91891001164 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 91891001165 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 91891001166 putative active site [active] 91891001167 phosphogluconate dehydratase; Validated; Region: PRK09054 91891001168 6-phosphogluconate dehydratase; Region: edd; TIGR01196 91891001169 Glucokinase; Region: Glucokinase; pfam02685 91891001170 glucokinase, proteobacterial type; Region: glk; TIGR00749 91891001171 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 91891001172 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 91891001173 active site 91891001174 intersubunit interface [polypeptide binding]; other site 91891001175 catalytic residue [active] 91891001176 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 91891001177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001178 putative substrate translocation pore; other site 91891001179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001180 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 91891001181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891001182 salt bridge; other site 91891001183 non-specific DNA binding site [nucleotide binding]; other site 91891001184 sequence-specific DNA binding site [nucleotide binding]; other site 91891001185 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 91891001186 ferrochelatase; Reviewed; Region: hemH; PRK00035 91891001187 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 91891001188 C-terminal domain interface [polypeptide binding]; other site 91891001189 active site 91891001190 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 91891001191 active site 91891001192 N-terminal domain interface [polypeptide binding]; other site 91891001193 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891001194 DNA-binding site [nucleotide binding]; DNA binding site 91891001195 RNA-binding motif; other site 91891001196 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 91891001197 HIT family signature motif; other site 91891001198 catalytic residue [active] 91891001199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 91891001200 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 91891001201 active site 91891001202 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 91891001203 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 91891001204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891001205 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891001206 Predicted membrane protein [Function unknown]; Region: COG1289 91891001207 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 91891001208 Predicted transcriptional regulators [Transcription]; Region: COG1733 91891001209 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 91891001210 Uncharacterized conserved protein [Function unknown]; Region: COG4278 91891001211 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891001212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891001213 S-adenosylmethionine binding site [chemical binding]; other site 91891001214 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001215 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891001216 Protein of unknown function (DUF3773); Region: DUF3773; pfam12608 91891001217 Dot/Icm secretion system protein (dot_icm_IcmQ); Region: Dot_icm_IcmQ; pfam09475 91891001218 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 91891001219 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 91891001220 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 91891001221 ligand binding site [chemical binding]; other site 91891001222 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891001223 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 91891001224 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 91891001225 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 91891001226 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 91891001227 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 91891001228 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 91891001229 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 91891001230 HNH nucleases; Region: HNHc; smart00507 91891001231 AAA-like domain; Region: AAA_10; pfam12846 91891001232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001233 metabolite-proton symporter; Region: 2A0106; TIGR00883 91891001234 putative substrate translocation pore; other site 91891001235 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 91891001236 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 91891001237 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 91891001238 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 91891001239 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 91891001240 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 91891001241 purine monophosphate binding site [chemical binding]; other site 91891001242 dimer interface [polypeptide binding]; other site 91891001243 putative catalytic residues [active] 91891001244 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 91891001245 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 91891001246 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 91891001247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891001248 S-adenosylmethionine binding site [chemical binding]; other site 91891001249 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 91891001250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 91891001251 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 91891001252 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 91891001253 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 91891001254 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 91891001255 carboxyltransferase (CT) interaction site; other site 91891001256 biotinylation site [posttranslational modification]; other site 91891001257 Dehydroquinase class II; Region: DHquinase_II; pfam01220 91891001258 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 91891001259 trimer interface [polypeptide binding]; other site 91891001260 active site 91891001261 dimer interface [polypeptide binding]; other site 91891001262 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891001263 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891001264 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 91891001265 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 91891001266 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 91891001267 active site 91891001268 Zn binding site [ion binding]; other site 91891001269 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891001270 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 91891001271 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 91891001272 putative catalytic site [active] 91891001273 putative metal binding site [ion binding]; other site 91891001274 putative phosphate binding site [ion binding]; other site 91891001275 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 91891001276 active site 91891001277 intersubunit interface [polypeptide binding]; other site 91891001278 catalytic residue [active] 91891001279 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 91891001280 ferredoxin-NADP reductase; Provisional; Region: PRK10926 91891001281 FAD binding pocket [chemical binding]; other site 91891001282 FAD binding motif [chemical binding]; other site 91891001283 phosphate binding motif [ion binding]; other site 91891001284 beta-alpha-beta structure motif; other site 91891001285 NAD binding pocket [chemical binding]; other site 91891001286 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 91891001287 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 91891001288 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 91891001289 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 91891001290 dimerization domain swap beta strand [polypeptide binding]; other site 91891001291 regulatory protein interface [polypeptide binding]; other site 91891001292 active site 91891001293 regulatory phosphorylation site [posttranslational modification]; other site 91891001294 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 91891001295 30S subunit binding site; other site 91891001296 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 91891001297 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 91891001298 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 91891001299 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 91891001300 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 91891001301 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 91891001302 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 91891001303 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 91891001304 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 91891001305 oligomer interface [polypeptide binding]; other site 91891001306 active site 91891001307 metal binding site [ion binding]; metal-binding site 91891001308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891001309 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001310 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891001311 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 91891001312 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 91891001313 HflK protein; Region: hflK; TIGR01933 91891001314 FtsH protease regulator HflC; Provisional; Region: PRK11029 91891001315 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 91891001316 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 91891001317 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 91891001318 GDP-binding site [chemical binding]; other site 91891001319 ACT binding site; other site 91891001320 IMP binding site; other site 91891001321 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 91891001322 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 91891001323 Arginine repressor [Transcription]; Region: ArgR; COG1438 91891001324 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 91891001325 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891001326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891001327 substrate binding pocket [chemical binding]; other site 91891001328 membrane-bound complex binding site; other site 91891001329 hinge residues; other site 91891001330 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 91891001331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891001332 dimer interface [polypeptide binding]; other site 91891001333 conserved gate region; other site 91891001334 putative PBP binding loops; other site 91891001335 ABC-ATPase subunit interface; other site 91891001336 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 91891001337 ATP-binding cassette domain of the binding protein-dependent transport systems; Region: ABC_Class3; cd03229 91891001338 Walker A/P-loop; other site 91891001339 ATP binding site [chemical binding]; other site 91891001340 Q-loop/lid; other site 91891001341 ABC transporter signature motif; other site 91891001342 Walker B; other site 91891001343 D-loop; other site 91891001344 H-loop/switch region; other site 91891001345 argininosuccinate synthase; Provisional; Region: PRK13820 91891001346 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 91891001347 ANP binding site [chemical binding]; other site 91891001348 Substrate Binding Site II [chemical binding]; other site 91891001349 Substrate Binding Site I [chemical binding]; other site 91891001350 Lyase; Region: Lyase_1; pfam00206 91891001351 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 91891001352 active sites [active] 91891001353 tetramer interface [polypeptide binding]; other site 91891001354 ornithine carbamoyltransferase; Provisional; Region: PRK00779 91891001355 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 91891001356 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 91891001357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 91891001358 active site 91891001359 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 91891001360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 91891001361 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 91891001362 C-terminal peptidase (prc); Region: prc; TIGR00225 91891001363 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 91891001364 protein binding site [polypeptide binding]; other site 91891001365 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 91891001366 Catalytic dyad [active] 91891001367 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 91891001368 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 91891001369 Peptidase family M23; Region: Peptidase_M23; pfam01551 91891001370 phosphoglyceromutase; Provisional; Region: PRK05434 91891001371 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 91891001372 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 91891001373 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 91891001374 catalytic residue [active] 91891001375 putative FPP diphosphate binding site; other site 91891001376 putative FPP binding hydrophobic cleft; other site 91891001377 dimer interface [polypeptide binding]; other site 91891001378 putative IPP diphosphate binding site; other site 91891001379 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 91891001380 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 91891001381 zinc metallopeptidase RseP; Provisional; Region: PRK10779 91891001382 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 91891001383 active site 91891001384 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 91891001385 protein binding site [polypeptide binding]; other site 91891001386 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 91891001387 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 91891001388 putative substrate binding region [chemical binding]; other site 91891001389 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 91891001390 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 91891001391 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 91891001392 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 91891001393 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 91891001394 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 91891001395 Surface antigen; Region: Bac_surface_Ag; pfam01103 91891001396 periplasmic chaperone; Provisional; Region: PRK10780 91891001397 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 91891001398 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 91891001399 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 91891001400 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 91891001401 trimer interface [polypeptide binding]; other site 91891001402 active site 91891001403 UDP-GlcNAc binding site [chemical binding]; other site 91891001404 lipid binding site [chemical binding]; lipid-binding site 91891001405 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 91891001406 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 91891001407 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 91891001408 active site 91891001409 camphor resistance protein CrcB; Provisional; Region: PRK14217 91891001410 seryl-tRNA synthetase; Provisional; Region: PRK05431 91891001411 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 91891001412 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 91891001413 dimer interface [polypeptide binding]; other site 91891001414 active site 91891001415 motif 1; other site 91891001416 motif 2; other site 91891001417 motif 3; other site 91891001418 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 91891001419 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 91891001420 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891001421 Methyltransferase domain; Region: Methyltransf_12; pfam08242 91891001422 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 91891001423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 91891001424 active site 91891001425 catalytic tetrad [active] 91891001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891001427 S-adenosylmethionine binding site [chemical binding]; other site 91891001428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891001429 hypothetical protein; Provisional; Region: PRK08233 91891001430 AAA domain; Region: AAA_18; pfam13238 91891001431 active site 91891001432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 91891001433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891001434 Coenzyme A binding pocket [chemical binding]; other site 91891001435 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 91891001436 Phosphotransferase enzyme family; Region: APH; pfam01636 91891001437 active site 91891001438 substrate binding site [chemical binding]; other site 91891001439 ATP binding site [chemical binding]; other site 91891001440 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 91891001441 substrate binding site [chemical binding]; other site 91891001442 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 91891001443 dimer interface [polypeptide binding]; other site 91891001444 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 91891001445 Mn binding site [ion binding]; other site 91891001446 K binding site [ion binding]; other site 91891001447 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 91891001448 RDD family; Region: RDD; pfam06271 91891001449 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 91891001450 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 91891001451 Iron-sulfur protein interface; other site 91891001452 proximal quinone binding site [chemical binding]; other site 91891001453 SdhD (CybS) interface [polypeptide binding]; other site 91891001454 proximal heme binding site [chemical binding]; other site 91891001455 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 91891001456 SdhC subunit interface [polypeptide binding]; other site 91891001457 proximal heme binding site [chemical binding]; other site 91891001458 cardiolipin binding site; other site 91891001459 Iron-sulfur protein interface; other site 91891001460 proximal quinone binding site [chemical binding]; other site 91891001461 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 91891001462 L-aspartate oxidase; Provisional; Region: PRK06175 91891001463 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 91891001464 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 91891001465 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 91891001466 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 91891001467 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 91891001468 TPP-binding site [chemical binding]; other site 91891001469 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 91891001470 dimer interface [polypeptide binding]; other site 91891001471 PYR/PP interface [polypeptide binding]; other site 91891001472 TPP binding site [chemical binding]; other site 91891001473 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 91891001474 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 91891001475 E3 interaction surface; other site 91891001476 lipoyl attachment site [posttranslational modification]; other site 91891001477 e3 binding domain; Region: E3_binding; pfam02817 91891001478 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 91891001479 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 91891001480 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 91891001481 CoA-ligase; Region: Ligase_CoA; pfam00549 91891001482 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 91891001483 CoA binding domain; Region: CoA_binding; smart00881 91891001484 CoA-ligase; Region: Ligase_CoA; pfam00549 91891001485 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 91891001486 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 91891001487 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 91891001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001489 D-galactonate transporter; Region: 2A0114; TIGR00893 91891001490 putative substrate translocation pore; other site 91891001491 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 91891001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 91891001493 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 91891001494 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 91891001495 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 91891001496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891001497 active site 91891001498 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 91891001499 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 91891001500 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 91891001501 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 91891001502 active site 91891001503 (T/H)XGH motif; other site 91891001504 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 91891001505 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 91891001506 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 91891001507 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 91891001508 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 91891001509 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 91891001510 ligand binding site [chemical binding]; other site 91891001511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 91891001512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 91891001513 putative acyl-acceptor binding pocket; other site 91891001514 multidrug efflux system protein; Provisional; Region: PRK11431 91891001515 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 91891001516 active site 91891001517 DNA polymerase IV; Validated; Region: PRK02406 91891001518 DNA binding site [nucleotide binding] 91891001519 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 91891001520 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 91891001521 DNA binding site [nucleotide binding] 91891001522 catalytic residue [active] 91891001523 H2TH interface [polypeptide binding]; other site 91891001524 putative catalytic residues [active] 91891001525 turnover-facilitating residue; other site 91891001526 intercalation triad [nucleotide binding]; other site 91891001527 8OG recognition residue [nucleotide binding]; other site 91891001528 putative reading head residues; other site 91891001529 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 91891001530 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 91891001531 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 91891001532 Fatty acid desaturase; Region: FA_desaturase; pfam00487 91891001533 Di-iron ligands [ion binding]; other site 91891001534 Transposase; Region: DDE_Tnp_ISL3; pfam01610 91891001535 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 91891001536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891001537 NAD(P) binding site [chemical binding]; other site 91891001538 active site 91891001539 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 91891001540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891001541 NAD(P) binding site [chemical binding]; other site 91891001542 active site 91891001543 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 91891001544 Phasin protein; Region: Phasin_2; cl11491 91891001545 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 91891001546 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 91891001547 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 91891001548 putative peptidase; Provisional; Region: PRK11649 91891001549 Peptidase family M23; Region: Peptidase_M23; pfam01551 91891001550 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 91891001551 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 91891001552 active site 91891001553 HIGH motif; other site 91891001554 dimer interface [polypeptide binding]; other site 91891001555 KMSKS motif; other site 91891001556 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 91891001557 RNA binding surface [nucleotide binding]; other site 91891001558 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 91891001559 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 91891001560 hinge; other site 91891001561 active site 91891001562 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 91891001563 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 91891001564 trimer interface [polypeptide binding]; other site 91891001565 putative metal binding site [ion binding]; other site 91891001566 glutathione reductase; Validated; Region: PRK06116 91891001567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 91891001568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 91891001569 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 91891001570 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 91891001571 adenosine deaminase; Provisional; Region: PRK09358 91891001572 active site 91891001573 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 91891001574 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 91891001575 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 91891001576 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 91891001577 hypothetical protein; Validated; Region: PRK00228 91891001578 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 91891001579 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 91891001580 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 91891001581 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 91891001582 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 91891001583 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 91891001584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891001585 Walker A motif; other site 91891001586 ATP binding site [chemical binding]; other site 91891001587 Walker B motif; other site 91891001588 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 91891001589 Membrane fusogenic activity; Region: BMFP; pfam04380 91891001590 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 91891001591 Nitrogen regulatory protein P-II; Region: P-II; smart00938 91891001592 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 91891001593 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 91891001594 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 91891001595 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 91891001596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891001597 catalytic residue [active] 91891001598 Uncharacterized conserved protein [Function unknown]; Region: COG0398 91891001599 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 91891001600 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 91891001601 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 91891001602 putative acyl-acceptor binding pocket; other site 91891001603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 91891001604 acyl-activating enzyme (AAE) consensus motif; other site 91891001605 AMP binding site [chemical binding]; other site 91891001606 active site 91891001607 CoA binding site [chemical binding]; other site 91891001608 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 91891001609 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 91891001610 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 91891001611 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 91891001612 Transcriptional regulator; Region: Rrf2; pfam02082 91891001613 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 91891001614 putative ABC transporter; Region: ycf24; CHL00085 91891001615 FeS assembly ATPase SufC; Region: sufC; TIGR01978 91891001616 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 91891001617 Walker A/P-loop; other site 91891001618 ATP binding site [chemical binding]; other site 91891001619 Q-loop/lid; other site 91891001620 ABC transporter signature motif; other site 91891001621 Walker B; other site 91891001622 D-loop; other site 91891001623 H-loop/switch region; other site 91891001624 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 91891001625 FeS assembly protein SufD; Region: sufD; TIGR01981 91891001626 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 91891001627 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 91891001628 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 91891001629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891001630 catalytic residue [active] 91891001631 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 91891001632 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 91891001633 trimerization site [polypeptide binding]; other site 91891001634 active site 91891001635 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 91891001636 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 91891001637 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 91891001638 motif 1; other site 91891001639 dimer interface [polypeptide binding]; other site 91891001640 active site 91891001641 motif 2; other site 91891001642 motif 3; other site 91891001643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891001644 S-adenosylmethionine binding site [chemical binding]; other site 91891001645 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 91891001646 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 91891001647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001648 putative substrate translocation pore; other site 91891001649 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 91891001650 Domain of unknown function DUF21; Region: DUF21; pfam01595 91891001651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 91891001652 Transporter associated domain; Region: CorC_HlyC; smart01091 91891001653 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 91891001654 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 91891001655 putative NAD(P) binding site [chemical binding]; other site 91891001656 putative substrate binding site [chemical binding]; other site 91891001657 catalytic Zn binding site [ion binding]; other site 91891001658 structural Zn binding site [ion binding]; other site 91891001659 dimer interface [polypeptide binding]; other site 91891001660 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 91891001661 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 91891001662 active site 91891001663 catalytic residues [active] 91891001664 metal binding site [ion binding]; metal-binding site 91891001665 CoA binding domain; Region: CoA_binding_2; pfam13380 91891001666 7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138 91891001667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 91891001668 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 91891001669 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 91891001670 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 91891001671 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 91891001672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 91891001673 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 91891001674 Cupin domain; Region: Cupin_2; cl17218 91891001675 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 91891001676 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 91891001677 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 91891001678 Competence protein; Region: Competence; pfam03772 91891001679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 91891001680 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 91891001681 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 91891001682 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 91891001683 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 91891001684 PilX N-terminal; Region: PilX_N; pfam14341 91891001685 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 91891001686 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 91891001687 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 91891001688 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 91891001689 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 91891001690 Type II transport protein GspH; Region: GspH; pfam12019 91891001691 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 91891001692 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 91891001693 putative active site [active] 91891001694 NodB motif; other site 91891001695 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 91891001696 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 91891001697 thymidine kinase; Provisional; Region: PRK04296 91891001698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891001700 putative substrate translocation pore; other site 91891001701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001702 putative substrate translocation pore; other site 91891001703 D-galactonate transporter; Region: 2A0114; TIGR00893 91891001704 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 91891001705 phosphopentomutase; Provisional; Region: PRK05362 91891001706 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891001707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891001708 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891001709 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891001710 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 91891001711 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 91891001712 active site 91891001713 HslU subunit interaction site [polypeptide binding]; other site 91891001714 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 91891001715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891001716 Walker A motif; other site 91891001717 ATP binding site [chemical binding]; other site 91891001718 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 91891001719 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 91891001720 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 91891001721 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 91891001722 metal ion-dependent adhesion site (MIDAS); other site 91891001723 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 91891001724 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 91891001725 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 91891001726 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 91891001727 putative active site [active] 91891001728 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 91891001729 putative active site [active] 91891001730 putative catalytic site [active] 91891001731 putative DNA binding site [nucleotide binding]; other site 91891001732 putative phosphate binding site [ion binding]; other site 91891001733 metal binding site A [ion binding]; metal-binding site 91891001734 putative AP binding site [nucleotide binding]; other site 91891001735 putative metal binding site B [ion binding]; other site 91891001736 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 91891001737 putative catalytic site [active] 91891001738 putative phosphate binding site [ion binding]; other site 91891001739 active site 91891001740 metal binding site A [ion binding]; metal-binding site 91891001741 DNA binding site [nucleotide binding] 91891001742 putative AP binding site [nucleotide binding]; other site 91891001743 putative metal binding site B [ion binding]; other site 91891001744 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 91891001745 Malic enzyme, N-terminal domain; Region: malic; pfam00390 91891001746 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 91891001747 putative NAD(P) binding site [chemical binding]; other site 91891001748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001749 putative substrate translocation pore; other site 91891001750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891001751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891001752 putative substrate translocation pore; other site 91891001753 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891001754 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 91891001755 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 91891001756 aromatic amino acid transport protein; Region: araaP; TIGR00837 91891001757 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 91891001758 aromatic amino acid transport protein; Region: araaP; TIGR00837 91891001759 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 91891001760 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 91891001761 ligand binding site [chemical binding]; other site 91891001762 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891001763 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 91891001764 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891001765 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 91891001766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891001767 Walker A/P-loop; other site 91891001768 ATP binding site [chemical binding]; other site 91891001769 Q-loop/lid; other site 91891001770 ABC transporter signature motif; other site 91891001771 Walker B; other site 91891001772 D-loop; other site 91891001773 H-loop/switch region; other site 91891001774 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 91891001775 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 91891001776 Walker A/P-loop; other site 91891001777 ATP binding site [chemical binding]; other site 91891001778 Q-loop/lid; other site 91891001779 ABC transporter signature motif; other site 91891001780 Walker B; other site 91891001781 D-loop; other site 91891001782 H-loop/switch region; other site 91891001783 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 91891001784 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 91891001785 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 91891001786 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 91891001787 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 91891001788 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 91891001789 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 91891001790 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 91891001791 N-acetyl-D-glucosamine binding site [chemical binding]; other site 91891001792 catalytic residue [active] 91891001793 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 91891001794 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 91891001795 substrate binding site [chemical binding]; other site 91891001796 hexamer interface [polypeptide binding]; other site 91891001797 metal binding site [ion binding]; metal-binding site 91891001798 DoxX; Region: DoxX; pfam07681 91891001799 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 91891001800 hypothetical protein; Provisional; Region: PRK05409 91891001801 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 91891001802 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 91891001803 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 91891001804 nucleophile elbow; other site 91891001805 DoxX; Region: DoxX; pfam07681 91891001806 Predicted membrane protein [Function unknown]; Region: COG2259 91891001807 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 91891001808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 91891001809 acetoacetate decarboxylase; Provisional; Region: PRK02265 91891001810 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 91891001811 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 91891001812 cyclase homology domain; Region: CHD; cd07302 91891001813 nucleotidyl binding site; other site 91891001814 metal binding site [ion binding]; metal-binding site 91891001815 dimer interface [polypeptide binding]; other site 91891001816 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 91891001817 hypothetical protein; Provisional; Region: PRK05409 91891001818 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891001819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891001820 substrate binding pocket [chemical binding]; other site 91891001821 membrane-bound complex binding site; other site 91891001822 hinge residues; other site 91891001823 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 91891001824 metal binding triad; other site 91891001825 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 91891001826 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 91891001827 metal binding triad; other site 91891001828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891001829 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891001830 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 91891001831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891001832 Walker A/P-loop; other site 91891001833 ATP binding site [chemical binding]; other site 91891001834 Q-loop/lid; other site 91891001835 ABC transporter signature motif; other site 91891001836 Walker B; other site 91891001837 D-loop; other site 91891001838 H-loop/switch region; other site 91891001839 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 91891001840 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 91891001841 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 91891001842 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 91891001843 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 91891001844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891001845 FeS/SAM binding site; other site 91891001846 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891001847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891001848 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891001849 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891001850 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 91891001851 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 91891001852 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 91891001853 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 91891001854 DsbD alpha interface [polypeptide binding]; other site 91891001855 catalytic residues [active] 91891001856 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 91891001857 oligomerisation interface [polypeptide binding]; other site 91891001858 mobile loop; other site 91891001859 roof hairpin; other site 91891001860 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 91891001861 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 91891001862 ring oligomerisation interface [polypeptide binding]; other site 91891001863 ATP/Mg binding site [chemical binding]; other site 91891001864 stacking interactions; other site 91891001865 hinge regions; other site 91891001866 Ferritin-like domain; Region: Ferritin; pfam00210 91891001867 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 91891001868 dimerization interface [polypeptide binding]; other site 91891001869 DPS ferroxidase diiron center [ion binding]; other site 91891001870 ion pore; other site 91891001871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891001872 Transposase, Mutator family; Region: Transposase_mut; pfam00872 91891001873 MULE transposase domain; Region: MULE; pfam10551 91891001874 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891001875 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 91891001876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891001877 Mg2+ binding site [ion binding]; other site 91891001878 G-X-G motif; other site 91891001879 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 91891001880 anchoring element; other site 91891001881 dimer interface [polypeptide binding]; other site 91891001882 ATP binding site [chemical binding]; other site 91891001883 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 91891001884 active site 91891001885 metal binding site [ion binding]; metal-binding site 91891001886 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 91891001887 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 91891001888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 91891001889 Walker A/P-loop; other site 91891001890 ATP binding site [chemical binding]; other site 91891001891 Q-loop/lid; other site 91891001892 ABC transporter signature motif; other site 91891001893 Walker B; other site 91891001894 D-loop; other site 91891001895 H-loop/switch region; other site 91891001896 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 91891001897 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 91891001898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 91891001899 Walker A/P-loop; other site 91891001900 ATP binding site [chemical binding]; other site 91891001901 Q-loop/lid; other site 91891001902 ABC transporter signature motif; other site 91891001903 Walker B; other site 91891001904 D-loop; other site 91891001905 H-loop/switch region; other site 91891001906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 91891001907 prolyl-tRNA synthetase; Provisional; Region: PRK09194 91891001908 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 91891001909 dimer interface [polypeptide binding]; other site 91891001910 motif 1; other site 91891001911 active site 91891001912 motif 2; other site 91891001913 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 91891001914 putative deacylase active site [active] 91891001915 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 91891001916 active site 91891001917 motif 3; other site 91891001918 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 91891001919 anticodon binding site; other site 91891001920 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 91891001921 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001922 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891001923 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001924 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891001925 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891001926 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 91891001927 Sulfate transporter family; Region: Sulfate_transp; pfam00916 91891001928 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 91891001929 active site clefts [active] 91891001930 zinc binding site [ion binding]; other site 91891001931 dimer interface [polypeptide binding]; other site 91891001932 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 91891001933 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 91891001934 Ligand Binding Site [chemical binding]; other site 91891001935 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 91891001936 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 91891001937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891001938 S-adenosylmethionine binding site [chemical binding]; other site 91891001939 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 91891001940 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 91891001941 substrate-cofactor binding pocket; other site 91891001942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891001943 catalytic residue [active] 91891001944 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 91891001945 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 91891001946 NAD(P) binding site [chemical binding]; other site 91891001947 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 91891001948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891001949 Walker A/P-loop; other site 91891001950 ATP binding site [chemical binding]; other site 91891001951 Q-loop/lid; other site 91891001952 ABC transporter signature motif; other site 91891001953 Walker B; other site 91891001954 D-loop; other site 91891001955 H-loop/switch region; other site 91891001956 ABC transporter; Region: ABC_tran_2; pfam12848 91891001957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891001958 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891001959 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 91891001960 Predicted transporter component [General function prediction only]; Region: COG2391 91891001961 Sulphur transport; Region: Sulf_transp; pfam04143 91891001962 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 91891001963 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891001964 formimidoylglutamase; Provisional; Region: PRK13775 91891001965 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 91891001966 putative active site [active] 91891001967 putative metal binding site [ion binding]; other site 91891001968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891001969 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 91891001970 NAD(P) binding site [chemical binding]; other site 91891001971 active site 91891001972 imidazolonepropionase; Validated; Region: PRK09356 91891001973 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 91891001974 active site 91891001975 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 91891001976 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 91891001977 Predicted membrane protein [Function unknown]; Region: COG1297 91891001978 putative oligopeptide transporter, OPT family; Region: TIGR00733 91891001979 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891001980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 91891001981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891001982 dimer interface [polypeptide binding]; other site 91891001983 phosphorylation site [posttranslational modification] 91891001984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891001985 ATP binding site [chemical binding]; other site 91891001986 Mg2+ binding site [ion binding]; other site 91891001987 G-X-G motif; other site 91891001988 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 91891001989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891001990 active site 91891001991 phosphorylation site [posttranslational modification] 91891001992 intermolecular recognition site; other site 91891001993 dimerization interface [polypeptide binding]; other site 91891001994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 91891001995 DNA binding site [nucleotide binding] 91891001996 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 91891001997 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 91891001998 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 91891001999 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 91891002000 HIGH motif; other site 91891002001 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 91891002002 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 91891002003 active site 91891002004 KMSKS motif; other site 91891002005 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 91891002006 tRNA binding surface [nucleotide binding]; other site 91891002007 anticodon binding site; other site 91891002008 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 91891002009 multidrug efflux protein; Reviewed; Region: PRK09579 91891002010 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 91891002011 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891002012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891002013 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891002014 BON domain; Region: BON; pfam04972 91891002015 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 91891002016 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 91891002017 dimer interface [polypeptide binding]; other site 91891002018 active site 91891002019 glycine-pyridoxal phosphate binding site [chemical binding]; other site 91891002020 folate binding site [chemical binding]; other site 91891002021 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 91891002022 ATP cone domain; Region: ATP-cone; pfam03477 91891002023 transcription antitermination factor NusB; Region: nusB; TIGR01951 91891002024 putative RNA binding site [nucleotide binding]; other site 91891002025 thiamine monophosphate kinase; Provisional; Region: PRK05731 91891002026 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 91891002027 ATP binding site [chemical binding]; other site 91891002028 dimerization interface [polypeptide binding]; other site 91891002029 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 91891002030 tetramer interfaces [polypeptide binding]; other site 91891002031 binuclear metal-binding site [ion binding]; other site 91891002032 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 91891002033 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 91891002034 NAD synthetase; Provisional; Region: PRK13981 91891002035 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 91891002036 multimer interface [polypeptide binding]; other site 91891002037 active site 91891002038 catalytic triad [active] 91891002039 protein interface 1 [polypeptide binding]; other site 91891002040 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 91891002041 homodimer interface [polypeptide binding]; other site 91891002042 NAD binding pocket [chemical binding]; other site 91891002043 ATP binding pocket [chemical binding]; other site 91891002044 Mg binding site [ion binding]; other site 91891002045 active-site loop [active] 91891002046 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 91891002047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891002048 ATP binding site [chemical binding]; other site 91891002049 putative Mg++ binding site [ion binding]; other site 91891002050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891002051 nucleotide binding region [chemical binding]; other site 91891002052 ATP-binding site [chemical binding]; other site 91891002053 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 91891002054 replicative DNA helicase; Region: DnaB; TIGR00665 91891002055 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 91891002056 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 91891002057 Walker A motif; other site 91891002058 ATP binding site [chemical binding]; other site 91891002059 Walker B motif; other site 91891002060 DNA binding loops [nucleotide binding] 91891002061 alanine racemase; Reviewed; Region: alr; PRK00053 91891002062 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 91891002063 active site 91891002064 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 91891002065 substrate binding site [chemical binding]; other site 91891002066 catalytic residues [active] 91891002067 dimer interface [polypeptide binding]; other site 91891002068 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 91891002069 FOG: CBS domain [General function prediction only]; Region: COG0517 91891002070 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 91891002071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 91891002072 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 91891002073 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 91891002074 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891002075 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891002076 metal binding site [ion binding]; metal-binding site 91891002077 active site 91891002078 I-site; other site 91891002079 lipoyl synthase; Provisional; Region: PRK05481 91891002080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891002081 FeS/SAM binding site; other site 91891002082 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 91891002083 GIY-YIG motif/motif A; other site 91891002084 putative active site [active] 91891002085 putative metal binding site [ion binding]; other site 91891002086 POT family; Region: PTR2; cl17359 91891002087 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 91891002088 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891002089 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891002090 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891002091 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891002092 Methyltransferase domain; Region: Methyltransf_11; pfam08241 91891002093 S-adenosylmethionine binding site [chemical binding]; other site 91891002094 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 91891002095 Ligand Binding Site [chemical binding]; other site 91891002096 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 91891002097 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 91891002098 substrate binding site [chemical binding]; other site 91891002099 glutamase interaction surface [polypeptide binding]; other site 91891002100 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 91891002101 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 91891002102 putative active site [active] 91891002103 oxyanion strand; other site 91891002104 catalytic triad [active] 91891002105 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 91891002106 ligand binding site; other site 91891002107 tetramer interface; other site 91891002108 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 91891002109 NeuB family; Region: NeuB; pfam03102 91891002110 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 91891002111 NeuB binding interface [polypeptide binding]; other site 91891002112 putative substrate binding site [chemical binding]; other site 91891002113 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 91891002114 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 91891002115 active site 91891002116 homodimer interface [polypeptide binding]; other site 91891002117 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 91891002118 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 91891002119 putative trimer interface [polypeptide binding]; other site 91891002120 putative CoA binding site [chemical binding]; other site 91891002121 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 91891002122 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 91891002123 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 91891002124 inhibitor-cofactor binding pocket; inhibition site 91891002125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891002126 catalytic residue [active] 91891002127 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 91891002128 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 91891002129 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 91891002130 NADP binding site [chemical binding]; other site 91891002131 active site 91891002132 putative substrate binding site [chemical binding]; other site 91891002133 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 91891002134 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 91891002135 NAD binding site [chemical binding]; other site 91891002136 substrate binding site [chemical binding]; other site 91891002137 homodimer interface [polypeptide binding]; other site 91891002138 active site 91891002139 Phosphoglucose isomerase; Region: PGI; pfam00342 91891002140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891002141 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 91891002142 active site 91891002143 dimer interface [polypeptide binding]; other site 91891002144 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 91891002145 dimer interface [polypeptide binding]; other site 91891002146 active site 91891002147 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 91891002148 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 91891002149 substrate binding site; other site 91891002150 tetramer interface; other site 91891002151 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 91891002152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891002153 NAD(P) binding site [chemical binding]; other site 91891002154 active site 91891002155 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 91891002156 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 91891002157 Mg++ binding site [ion binding]; other site 91891002158 putative catalytic motif [active] 91891002159 putative substrate binding site [chemical binding]; other site 91891002160 Radical SAM superfamily; Region: Radical_SAM; pfam04055 91891002161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891002162 FeS/SAM binding site; other site 91891002163 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 91891002164 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 91891002165 substrate binding site [chemical binding]; other site 91891002166 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 91891002167 NeuB family; Region: NeuB; pfam03102 91891002168 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 91891002169 NeuB binding interface [polypeptide binding]; other site 91891002170 putative substrate binding site [chemical binding]; other site 91891002171 Methyltransferase domain; Region: Methyltransf_31; pfam13847 91891002172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891002173 S-adenosylmethionine binding site [chemical binding]; other site 91891002174 Transposase; Region: HTH_Tnp_1; pfam01527 91891002175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 91891002176 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 91891002177 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 91891002178 putative active site [active] 91891002179 putative NTP binding site [chemical binding]; other site 91891002180 putative nucleic acid binding site [nucleotide binding]; other site 91891002181 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 91891002182 putative transposase OrfB; Reviewed; Region: PHA02517 91891002183 HTH-like domain; Region: HTH_21; pfam13276 91891002184 Integrase core domain; Region: rve; pfam00665 91891002185 Integrase core domain; Region: rve_2; pfam13333 91891002186 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891002187 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891002188 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891002189 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891002190 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 91891002191 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 91891002192 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 91891002193 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 91891002194 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 91891002195 Walker A/P-loop; other site 91891002196 ATP binding site [chemical binding]; other site 91891002197 Q-loop/lid; other site 91891002198 ABC transporter signature motif; other site 91891002199 Walker B; other site 91891002200 D-loop; other site 91891002201 H-loop/switch region; other site 91891002202 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 91891002203 putative carbohydrate binding site [chemical binding]; other site 91891002204 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 91891002205 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 91891002206 Probable Catalytic site; other site 91891002207 metal-binding site 91891002208 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 91891002209 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 91891002210 Probable Catalytic site; other site 91891002211 metal-binding site 91891002212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 91891002213 carbon storage regulator; Provisional; Region: PRK01712 91891002214 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 91891002215 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 91891002216 Biotin operon repressor [Transcription]; Region: BirA; COG1654 91891002217 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 91891002218 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 91891002219 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 91891002220 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 91891002221 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 91891002222 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 91891002223 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 91891002224 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 91891002225 Ligand Binding Site [chemical binding]; other site 91891002226 TilS substrate binding domain; Region: TilS; pfam09179 91891002227 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 91891002228 Transposase IS200 like; Region: Y1_Tnp; cl00848 91891002229 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 91891002230 active site 91891002231 oxyanion hole [active] 91891002232 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 91891002233 catalytic triad [active] 91891002234 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 91891002235 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 91891002236 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 91891002237 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 91891002238 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 91891002239 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 91891002240 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 91891002241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891002242 muropeptide transporter; Reviewed; Region: ampG; PRK11902 91891002243 putative substrate translocation pore; other site 91891002244 Protein of unknown function (DUF3757); Region: DUF3757; pfam12582 91891002245 Quinolinate synthetase A protein; Region: NadA; pfam02445 91891002246 L-aspartate oxidase; Provisional; Region: PRK09077 91891002247 L-aspartate oxidase; Provisional; Region: PRK06175 91891002248 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 91891002249 adenylosuccinate lyase; Provisional; Region: PRK09285 91891002250 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 91891002251 tetramer interface [polypeptide binding]; other site 91891002252 active site 91891002253 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 91891002254 putative transporter; Provisional; Region: PRK11660 91891002255 Sulfate transporter family; Region: Sulfate_transp; pfam00916 91891002256 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 91891002257 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 91891002258 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 91891002259 active site 91891002260 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 91891002261 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 91891002262 active site 91891002263 phosphoenolpyruvate synthase; Validated; Region: PRK06464 91891002264 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 91891002265 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 91891002266 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 91891002267 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 91891002268 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 91891002269 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 91891002270 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 91891002271 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 91891002272 dimerization interface [polypeptide binding]; other site 91891002273 active site 91891002274 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 91891002275 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 91891002276 active site 91891002277 homodimer interface [polypeptide binding]; other site 91891002278 hypothetical protein; Provisional; Region: PRK08201 91891002279 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 91891002280 metal binding site [ion binding]; metal-binding site 91891002281 putative dimer interface [polypeptide binding]; other site 91891002282 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 91891002283 rod shape-determining protein MreB; Provisional; Region: PRK13927 91891002284 MreB and similar proteins; Region: MreB_like; cd10225 91891002285 nucleotide binding site [chemical binding]; other site 91891002286 Mg binding site [ion binding]; other site 91891002287 putative protofilament interaction site [polypeptide binding]; other site 91891002288 RodZ interaction site [polypeptide binding]; other site 91891002289 rod shape-determining protein MreC; Provisional; Region: PRK13922 91891002290 rod shape-determining protein MreC; Region: MreC; pfam04085 91891002291 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 91891002292 pseudouridine synthase; Region: TIGR00093 91891002293 active site 91891002294 isocitrate dehydrogenase; Validated; Region: PRK07362 91891002295 isocitrate dehydrogenase; Reviewed; Region: PRK07006 91891002296 Uncharacterized conserved protein [Function unknown]; Region: COG2127 91891002297 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 91891002298 Clp amino terminal domain; Region: Clp_N; pfam02861 91891002299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891002300 Walker A motif; other site 91891002301 ATP binding site [chemical binding]; other site 91891002302 Walker B motif; other site 91891002303 arginine finger; other site 91891002304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891002305 Walker A motif; other site 91891002306 ATP binding site [chemical binding]; other site 91891002307 Walker B motif; other site 91891002308 arginine finger; other site 91891002309 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 91891002310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891002311 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 91891002312 GIY-YIG motif/motif A; other site 91891002313 putative active site [active] 91891002314 putative metal binding site [ion binding]; other site 91891002315 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 91891002316 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 91891002317 putative metal binding site; other site 91891002318 O-Antigen ligase; Region: Wzy_C; cl04850 91891002319 Rhomboid family; Region: Rhomboid; cl11446 91891002320 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 91891002321 Peptidase family M23; Region: Peptidase_M23; pfam01551 91891002322 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 91891002323 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 91891002324 generic binding surface II; other site 91891002325 generic binding surface I; other site 91891002326 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 91891002327 Sporulation related domain; Region: SPOR; pfam05036 91891002328 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 91891002329 biofilm formation regulator HmsP; Provisional; Region: PRK11829 91891002330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 91891002331 dimerization interface [polypeptide binding]; other site 91891002332 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891002333 metal binding site [ion binding]; metal-binding site 91891002334 active site 91891002335 I-site; other site 91891002336 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891002337 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 91891002338 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 91891002339 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 91891002340 hypothetical protein; Provisional; Region: PRK06194 91891002341 classical (c) SDRs; Region: SDR_c; cd05233 91891002342 NAD(P) binding site [chemical binding]; other site 91891002343 active site 91891002344 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 91891002345 active site 91891002346 ribulose/triose binding site [chemical binding]; other site 91891002347 phosphate binding site [ion binding]; other site 91891002348 substrate (anthranilate) binding pocket [chemical binding]; other site 91891002349 product (indole) binding pocket [chemical binding]; other site 91891002350 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 91891002351 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 91891002352 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 91891002353 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 91891002354 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 91891002355 glutamine binding [chemical binding]; other site 91891002356 catalytic triad [active] 91891002357 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 91891002358 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 91891002359 Walker A/P-loop; other site 91891002360 ATP binding site [chemical binding]; other site 91891002361 Q-loop/lid; other site 91891002362 ABC transporter signature motif; other site 91891002363 Walker B; other site 91891002364 D-loop; other site 91891002365 H-loop/switch region; other site 91891002366 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 91891002367 OstA-like protein; Region: OstA; pfam03968 91891002368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 91891002369 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 91891002370 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 91891002371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891002372 active site 91891002373 motif I; other site 91891002374 motif II; other site 91891002375 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 91891002376 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 91891002377 putative active site [active] 91891002378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 91891002379 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 91891002380 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 91891002381 Walker A/P-loop; other site 91891002382 ATP binding site [chemical binding]; other site 91891002383 Q-loop/lid; other site 91891002384 ABC transporter signature motif; other site 91891002385 Walker B; other site 91891002386 D-loop; other site 91891002387 H-loop/switch region; other site 91891002388 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 91891002389 Permease; Region: Permease; cl00510 91891002390 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 91891002391 mce related protein; Region: MCE; pfam02470 91891002392 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 91891002393 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 91891002394 anti sigma factor interaction site; other site 91891002395 regulatory phosphorylation site [posttranslational modification]; other site 91891002396 BolA-like protein; Region: BolA; cl00386 91891002397 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 91891002398 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 91891002399 hinge; other site 91891002400 active site 91891002401 Uncharacterized conserved protein [Function unknown]; Region: COG0327 91891002402 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 91891002403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 91891002404 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 91891002405 Walker A/P-loop; other site 91891002406 ATP binding site [chemical binding]; other site 91891002407 Q-loop/lid; other site 91891002408 ABC transporter signature motif; other site 91891002409 Walker B; other site 91891002410 D-loop; other site 91891002411 H-loop/switch region; other site 91891002412 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 91891002413 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 91891002414 FtsX-like permease family; Region: FtsX; pfam02687 91891002415 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891002416 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891002417 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891002418 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 91891002419 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 91891002420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891002421 Walker A motif; other site 91891002422 ATP binding site [chemical binding]; other site 91891002423 Walker B motif; other site 91891002424 arginine finger; other site 91891002425 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 91891002426 putative inner membrane peptidase; Provisional; Region: PRK11778 91891002427 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 91891002428 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 91891002429 tandem repeat interface [polypeptide binding]; other site 91891002430 oligomer interface [polypeptide binding]; other site 91891002431 active site residues [active] 91891002432 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 91891002433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891002434 Walker A/P-loop; other site 91891002435 ATP binding site [chemical binding]; other site 91891002436 Q-loop/lid; other site 91891002437 ABC transporter signature motif; other site 91891002438 Walker B; other site 91891002439 D-loop; other site 91891002440 H-loop/switch region; other site 91891002441 CcmB protein; Region: CcmB; cl17444 91891002442 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 91891002443 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 91891002444 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 91891002445 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 91891002446 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 91891002447 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 91891002448 catalytic residues [active] 91891002449 central insert; other site 91891002450 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 91891002451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891002452 binding surface 91891002453 TPR motif; other site 91891002454 Dodecin; Region: Dodecin; pfam07311 91891002455 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 91891002456 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 91891002457 active site 91891002458 DNA binding site [nucleotide binding] 91891002459 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 91891002460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891002461 ATP binding site [chemical binding]; other site 91891002462 putative Mg++ binding site [ion binding]; other site 91891002463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891002464 nucleotide binding region [chemical binding]; other site 91891002465 ATP-binding site [chemical binding]; other site 91891002466 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 91891002467 HRDC domain; Region: HRDC; pfam00570 91891002468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 91891002469 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 91891002470 active site 91891002471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 91891002472 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 91891002473 substrate binding site [chemical binding]; other site 91891002474 oxyanion hole (OAH) forming residues; other site 91891002475 trimer interface [polypeptide binding]; other site 91891002476 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 91891002477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 91891002478 substrate binding site [chemical binding]; other site 91891002479 oxyanion hole (OAH) forming residues; other site 91891002480 trimer interface [polypeptide binding]; other site 91891002481 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 91891002482 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 91891002483 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 91891002484 G1 box; other site 91891002485 putative GEF interaction site [polypeptide binding]; other site 91891002486 GTP/Mg2+ binding site [chemical binding]; other site 91891002487 Switch I region; other site 91891002488 G2 box; other site 91891002489 G3 box; other site 91891002490 Switch II region; other site 91891002491 G4 box; other site 91891002492 G5 box; other site 91891002493 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 91891002494 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 91891002495 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 91891002496 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 91891002497 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 91891002498 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 91891002499 ligand binding site [chemical binding]; other site 91891002500 homodimer interface [polypeptide binding]; other site 91891002501 NAD(P) binding site [chemical binding]; other site 91891002502 trimer interface B [polypeptide binding]; other site 91891002503 trimer interface A [polypeptide binding]; other site 91891002504 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 91891002505 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 91891002506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 91891002507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891002508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891002509 metal binding site [ion binding]; metal-binding site 91891002510 active site 91891002511 I-site; other site 91891002512 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 91891002513 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 91891002514 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 91891002515 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 91891002516 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 91891002517 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 91891002518 metal binding site [ion binding]; metal-binding site 91891002519 dimer interface [polypeptide binding]; other site 91891002520 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 91891002521 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 91891002522 trimer interface [polypeptide binding]; other site 91891002523 active site 91891002524 substrate binding site [chemical binding]; other site 91891002525 CoA binding site [chemical binding]; other site 91891002526 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 91891002527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 91891002528 putative acyl-acceptor binding pocket; other site 91891002529 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 91891002530 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 91891002531 homodimer interface [polypeptide binding]; other site 91891002532 substrate-cofactor binding pocket; other site 91891002533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891002534 catalytic residue [active] 91891002535 PAS fold; Region: PAS_7; pfam12860 91891002536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891002537 PAS domain; Region: PAS_9; pfam13426 91891002538 putative active site [active] 91891002539 heme pocket [chemical binding]; other site 91891002540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891002541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891002542 metal binding site [ion binding]; metal-binding site 91891002543 active site 91891002544 I-site; other site 91891002545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891002546 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 91891002547 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 91891002548 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 91891002549 FAD binding domain; Region: FAD_binding_4; pfam01565 91891002550 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 91891002551 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 91891002552 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891002553 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 91891002554 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 91891002555 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 91891002556 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 91891002557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 91891002558 minor groove reading motif; other site 91891002559 helix-hairpin-helix signature motif; other site 91891002560 substrate binding pocket [chemical binding]; other site 91891002561 active site 91891002562 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 91891002563 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 91891002564 DNA binding and oxoG recognition site [nucleotide binding] 91891002565 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 91891002566 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 91891002567 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 91891002568 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 91891002569 protein binding site [polypeptide binding]; other site 91891002570 Isochorismatase family; Region: Isochorismatase; pfam00857 91891002571 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 91891002572 catalytic triad [active] 91891002573 dimer interface [polypeptide binding]; other site 91891002574 conserved cis-peptide bond; other site 91891002575 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 91891002576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891002577 NAD(P) binding site [chemical binding]; other site 91891002578 active site 91891002579 FlgN protein; Region: FlgN; pfam05130 91891002580 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 91891002581 SAF-like; Region: SAF_2; pfam13144 91891002582 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 91891002583 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 91891002584 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891002585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 91891002586 nucleotide binding site [chemical binding]; other site 91891002587 Type III pantothenate kinase; Region: Pan_kinase; cl17198 91891002588 cell division protein MraZ; Reviewed; Region: PRK00326 91891002589 MraZ protein; Region: MraZ; pfam02381 91891002590 MraZ protein; Region: MraZ; pfam02381 91891002591 MraW methylase family; Region: Methyltransf_5; cl17771 91891002592 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 91891002593 Cell division protein FtsL; Region: FtsL; pfam04999 91891002594 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 91891002595 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 91891002596 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 91891002597 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 91891002598 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 91891002599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 91891002600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 91891002601 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 91891002602 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 91891002603 ligand binding site [chemical binding]; other site 91891002604 NAD binding site [chemical binding]; other site 91891002605 catalytic site [active] 91891002606 homodimer interface [polypeptide binding]; other site 91891002607 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 91891002608 Peptidase family M50; Region: Peptidase_M50; pfam02163 91891002609 active site 91891002610 putative substrate binding region [chemical binding]; other site 91891002611 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 91891002612 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 91891002613 active site 91891002614 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 91891002615 Ligand binding site [chemical binding]; other site 91891002616 Electron transfer flavoprotein domain; Region: ETF; pfam01012 91891002617 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 91891002618 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 91891002619 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 91891002620 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 91891002621 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 91891002622 hexamer interface [polypeptide binding]; other site 91891002623 ligand binding site [chemical binding]; other site 91891002624 putative active site [active] 91891002625 NAD(P) binding site [chemical binding]; other site 91891002626 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 91891002627 Transglycosylase; Region: Transgly; pfam00912 91891002628 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 91891002629 Cell division protein FtsA; Region: FtsA; cl17206 91891002630 Competence protein A; Region: Competence_A; pfam11104 91891002631 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 91891002632 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 91891002633 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 91891002634 Pilus assembly protein, PilO; Region: PilO; pfam04350 91891002635 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 91891002636 Pilus assembly protein, PilP; Region: PilP; pfam04351 91891002637 AMIN domain; Region: AMIN; pfam11741 91891002638 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 91891002639 Secretin and TonB N terminus short domain; Region: STN; smart00965 91891002640 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 91891002641 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 91891002642 shikimate kinase; Reviewed; Region: aroK; PRK00131 91891002643 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 91891002644 ADP binding site [chemical binding]; other site 91891002645 magnesium binding site [ion binding]; other site 91891002646 putative shikimate binding site; other site 91891002647 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 91891002648 active site 91891002649 dimer interface [polypeptide binding]; other site 91891002650 metal binding site [ion binding]; metal-binding site 91891002651 AAA domain; Region: AAA_22; pfam13401 91891002652 Sporulation related domain; Region: SPOR; pfam05036 91891002653 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 91891002654 Ligand Binding Site [chemical binding]; other site 91891002655 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 91891002656 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 91891002657 active site 91891002658 Riboflavin kinase; Region: Flavokinase; smart00904 91891002659 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 91891002660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 91891002661 active site 91891002662 HIGH motif; other site 91891002663 nucleotide binding site [chemical binding]; other site 91891002664 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 91891002665 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 91891002666 active site 91891002667 KMSKS motif; other site 91891002668 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 91891002669 tRNA binding surface [nucleotide binding]; other site 91891002670 anticodon binding site; other site 91891002671 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 91891002672 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 91891002673 lipoprotein signal peptidase; Provisional; Region: PRK14787 91891002674 Class I aldolases; Region: Aldolase_Class_I; cl17187 91891002675 catalytic residue [active] 91891002676 GTPase Era; Reviewed; Region: era; PRK00089 91891002677 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 91891002678 G1 box; other site 91891002679 GTP/Mg2+ binding site [chemical binding]; other site 91891002680 Switch I region; other site 91891002681 G2 box; other site 91891002682 Switch II region; other site 91891002683 G3 box; other site 91891002684 G4 box; other site 91891002685 G5 box; other site 91891002686 KH domain; Region: KH_2; pfam07650 91891002687 Recombination protein O N terminal; Region: RecO_N; pfam11967 91891002688 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 91891002689 Recombination protein O C terminal; Region: RecO_C; pfam02565 91891002690 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891002691 Leucine-rich repeats; other site 91891002692 Substrate binding site [chemical binding]; other site 91891002693 Leucine rich repeat; Region: LRR_8; pfam13855 91891002694 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 91891002695 active site 91891002696 hydrophilic channel; other site 91891002697 dimerization interface [polypeptide binding]; other site 91891002698 catalytic residues [active] 91891002699 active site lid [active] 91891002700 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 91891002701 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 91891002702 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 91891002703 dimer interface [polypeptide binding]; other site 91891002704 PYR/PP interface [polypeptide binding]; other site 91891002705 TPP binding site [chemical binding]; other site 91891002706 substrate binding site [chemical binding]; other site 91891002707 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 91891002708 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 91891002709 TPP-binding site [chemical binding]; other site 91891002710 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 91891002711 YccA-like proteins; Region: YccA_like; cd10433 91891002712 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 91891002713 nitrilase; Region: PLN02798 91891002714 putative active site [active] 91891002715 catalytic triad [active] 91891002716 dimer interface [polypeptide binding]; other site 91891002717 protease TldD; Provisional; Region: tldD; PRK10735 91891002718 hypothetical protein; Provisional; Region: PRK10279 91891002719 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 91891002720 active site 91891002721 nucleophile elbow; other site 91891002722 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 91891002723 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 91891002724 acyl-activating enzyme (AAE) consensus motif; other site 91891002725 putative AMP binding site [chemical binding]; other site 91891002726 putative active site [active] 91891002727 putative CoA binding site [chemical binding]; other site 91891002728 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 91891002729 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 91891002730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891002731 ATP binding site [chemical binding]; other site 91891002732 putative Mg++ binding site [ion binding]; other site 91891002733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891002734 nucleotide binding region [chemical binding]; other site 91891002735 ATP-binding site [chemical binding]; other site 91891002736 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 91891002737 RmuC family; Region: RmuC; pfam02646 91891002738 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 91891002739 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 91891002740 nucleotide binding pocket [chemical binding]; other site 91891002741 K-X-D-G motif; other site 91891002742 catalytic site [active] 91891002743 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 91891002744 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 91891002745 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 91891002746 Dimer interface [polypeptide binding]; other site 91891002747 BRCT sequence motif; other site 91891002748 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505 91891002749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 91891002750 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 91891002751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891002752 dimer interface [polypeptide binding]; other site 91891002753 conserved gate region; other site 91891002754 putative PBP binding loops; other site 91891002755 ABC-ATPase subunit interface; other site 91891002756 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 91891002757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891002758 dimer interface [polypeptide binding]; other site 91891002759 conserved gate region; other site 91891002760 putative PBP binding loops; other site 91891002761 ABC-ATPase subunit interface; other site 91891002762 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 91891002763 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 91891002764 putative active site [active] 91891002765 putative PHP Thumb interface [polypeptide binding]; other site 91891002766 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 91891002767 generic binding surface II; other site 91891002768 generic binding surface I; other site 91891002769 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 91891002770 UbiA prenyltransferase family; Region: UbiA; pfam01040 91891002771 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 91891002772 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 91891002773 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 91891002774 NAD(P) binding site [chemical binding]; other site 91891002775 homodimer interface [polypeptide binding]; other site 91891002776 substrate binding site [chemical binding]; other site 91891002777 active site 91891002778 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 91891002779 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 91891002780 nucleotide binding site [chemical binding]; other site 91891002781 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 91891002782 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 91891002783 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 91891002784 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 91891002785 Catalytic site [active] 91891002786 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 91891002787 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 91891002788 active site 91891002789 DNA binding site [nucleotide binding] 91891002790 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 91891002791 Antirestriction protein (ArdA); Region: ArdA; pfam07275 91891002792 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 91891002793 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 91891002794 dimer interface [polypeptide binding]; other site 91891002795 ssDNA binding site [nucleotide binding]; other site 91891002796 tetramer (dimer of dimers) interface [polypeptide binding]; other site 91891002797 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 91891002798 Integrase; Region: Integrase_1; pfam12835 91891002799 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 91891002800 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 91891002801 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 91891002802 putative active site [active] 91891002803 putative NTP binding site [chemical binding]; other site 91891002804 putative nucleic acid binding site [nucleotide binding]; other site 91891002805 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 91891002806 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 91891002807 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 91891002808 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 91891002809 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 91891002810 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 91891002811 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 91891002812 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 91891002813 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 91891002814 Domain of unknown function DUF87; Region: DUF87; pfam01935 91891002815 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 91891002816 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 91891002817 basic region leucin zipper; Region: BRLZ; smart00338 91891002818 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 91891002819 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 91891002820 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 91891002821 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 91891002822 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 91891002823 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 91891002824 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 91891002825 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 91891002826 Global regulator protein family; Region: CsrA; pfam02599 91891002827 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 91891002828 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 91891002829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891002830 non-specific DNA binding site [nucleotide binding]; other site 91891002831 salt bridge; other site 91891002832 sequence-specific DNA binding site [nucleotide binding]; other site 91891002833 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 91891002834 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 91891002835 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891002836 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 91891002837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891002838 motif II; other site 91891002839 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 91891002840 Outer membrane efflux protein; Region: OEP; pfam02321 91891002841 Outer membrane efflux protein; Region: OEP; pfam02321 91891002842 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891002843 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891002844 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 91891002845 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 91891002846 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 91891002847 Beta-Casp domain; Region: Beta-Casp; smart01027 91891002848 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 91891002849 thymidine phosphorylase; Provisional; Region: PRK04350 91891002850 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 91891002851 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 91891002852 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 91891002853 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 91891002854 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 91891002855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891002856 active site 91891002857 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 91891002858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891002859 Soluble P-type ATPase [General function prediction only]; Region: COG4087 91891002860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891002861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891002862 metal binding site [ion binding]; metal-binding site 91891002863 active site 91891002864 I-site; other site 91891002865 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 91891002866 Outer membrane efflux protein; Region: OEP; pfam02321 91891002867 Outer membrane efflux protein; Region: OEP; pfam02321 91891002868 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 91891002869 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 91891002870 carboxyltransferase (CT) interaction site; other site 91891002871 biotinylation site [posttranslational modification]; other site 91891002872 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891002873 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 91891002874 Protein export membrane protein; Region: SecD_SecF; cl14618 91891002875 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 91891002876 Leucine carboxyl methyltransferase; Region: LCM; cl01306 91891002877 Uncharacterized conserved protein [Function unknown]; Region: COG4278 91891002878 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 91891002879 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 91891002880 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891002881 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891002882 Outer membrane efflux protein; Region: OEP; pfam02321 91891002883 Outer membrane efflux protein; Region: OEP; pfam02321 91891002884 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 91891002885 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 91891002886 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 91891002887 Multicopper oxidase; Region: Cu-oxidase; pfam00394 91891002888 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 91891002889 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 91891002890 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 91891002891 Predicted membrane protein [Function unknown]; Region: COG3212 91891002892 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 91891002893 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 91891002894 Evidence 7 : Gene remnant; Product type t : transporter 91891002895 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 91891002896 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 91891002897 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891002898 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 91891002899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 91891002900 dimerization interface [polypeptide binding]; other site 91891002901 putative DNA binding site [nucleotide binding]; other site 91891002902 putative Zn2+ binding site [ion binding]; other site 91891002903 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 91891002904 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 91891002905 metal-binding site [ion binding] 91891002906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891002907 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 91891002908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891002909 non-specific DNA binding site [nucleotide binding]; other site 91891002910 salt bridge; other site 91891002911 sequence-specific DNA binding site [nucleotide binding]; other site 91891002912 Heme NO binding; Region: HNOB; pfam07700 91891002913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891002914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891002915 metal binding site [ion binding]; metal-binding site 91891002916 active site 91891002917 I-site; other site 91891002918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891002919 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 91891002920 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 91891002921 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 91891002922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891002923 NAD(P) binding site [chemical binding]; other site 91891002924 active site 91891002925 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891002926 DNA-binding site [nucleotide binding]; DNA binding site 91891002927 RNA-binding motif; other site 91891002928 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891002929 Sel1-like repeats; Region: SEL1; smart00671 91891002930 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891002931 Sel1-like repeats; Region: SEL1; smart00671 91891002932 Sel1-like repeats; Region: SEL1; smart00671 91891002933 Sel1-like repeats; Region: SEL1; smart00671 91891002934 Sel1-like repeats; Region: SEL1; smart00671 91891002935 Sel1-like repeats; Region: SEL1; smart00671 91891002936 citrate-proton symporter; Provisional; Region: PRK15075 91891002937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891002938 putative substrate translocation pore; other site 91891002939 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 91891002940 active site 91891002941 catalytic residues [active] 91891002942 metal binding site [ion binding]; metal-binding site 91891002943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891002944 non-specific DNA binding site [nucleotide binding]; other site 91891002945 salt bridge; other site 91891002946 sequence-specific DNA binding site [nucleotide binding]; other site 91891002947 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 91891002948 integrase; Provisional; Region: PRK09692 91891002949 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 91891002950 active site 91891002951 Int/Topo IB signature motif; other site 91891002952 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 91891002953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891002954 non-specific DNA binding site [nucleotide binding]; other site 91891002955 salt bridge; other site 91891002956 sequence-specific DNA binding site [nucleotide binding]; other site 91891002957 YcfA-like protein; Region: YcfA; pfam07927 91891002958 Domain of unknown function (DUF927); Region: DUF927; pfam06048 91891002959 Helix-turn-helix domain; Region: HTH_17; pfam12728 91891002960 DNA binding domain, excisionase family; Region: excise; TIGR01764 91891002961 PIN domain; Region: PIN_3; pfam13470 91891002962 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 91891002963 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 91891002964 active site 91891002965 DNA binding site [nucleotide binding] 91891002966 Int/Topo IB signature motif; other site 91891002967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 91891002968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891002969 Coenzyme A binding pocket [chemical binding]; other site 91891002970 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 91891002971 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 91891002972 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891002973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891002974 S-adenosylmethionine binding site [chemical binding]; other site 91891002975 Fic family protein [Function unknown]; Region: COG3177 91891002976 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 91891002977 Fic/DOC family; Region: Fic; pfam02661 91891002978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891002979 Coenzyme A binding pocket [chemical binding]; other site 91891002980 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 91891002981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891002982 motif II; other site 91891002983 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 91891002984 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891002985 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 91891002986 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 91891002987 putative active site [active] 91891002988 putative NTP binding site [chemical binding]; other site 91891002989 putative nucleic acid binding site [nucleotide binding]; other site 91891002990 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 91891002991 Transposase; Region: HTH_Tnp_1; pfam01527 91891002992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 91891002993 Integrase core domain; Region: rve; pfam00665 91891002994 Integrase core domain; Region: rve_2; pfam13333 91891002995 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 91891002996 Phosphotransferase enzyme family; Region: APH; pfam01636 91891002997 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 91891002998 methionine sulfoxide reductase B; Provisional; Region: PRK00222 91891002999 SelR domain; Region: SelR; pfam01641 91891003000 EamA-like transporter family; Region: EamA; cl17759 91891003001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891003002 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 91891003003 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891003004 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 91891003005 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 91891003006 GIY-YIG motif/motif A; other site 91891003007 putative active site [active] 91891003008 putative metal binding site [ion binding]; other site 91891003009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891003010 PAS domain; Region: PAS_9; pfam13426 91891003011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891003012 PAS domain; Region: PAS_9; pfam13426 91891003013 putative active site [active] 91891003014 heme pocket [chemical binding]; other site 91891003015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891003016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891003017 metal binding site [ion binding]; metal-binding site 91891003018 active site 91891003019 I-site; other site 91891003020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891003021 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 91891003022 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 91891003023 tetramer interface [polypeptide binding]; other site 91891003024 dimer interface [polypeptide binding]; other site 91891003025 circadian clock protein KaiC; Reviewed; Region: PRK09302 91891003026 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891003027 Walker A motif; other site 91891003028 ATP binding site [chemical binding]; other site 91891003029 Walker B motif; other site 91891003030 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891003031 Walker A motif; other site 91891003032 ATP binding site [chemical binding]; other site 91891003033 Walker B motif; other site 91891003034 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 91891003035 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 91891003036 active site 91891003037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891003038 Coenzyme A binding pocket [chemical binding]; other site 91891003039 Beta-lactamase; Region: Beta-lactamase; pfam00144 91891003040 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 91891003041 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 91891003042 catalytic core [active] 91891003043 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 91891003044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 91891003045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 91891003046 catalytic residue [active] 91891003047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891003048 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 91891003049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891003050 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891003051 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891003052 substrate binding pocket [chemical binding]; other site 91891003053 membrane-bound complex binding site; other site 91891003054 hinge residues; other site 91891003055 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891003056 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891003057 substrate binding pocket [chemical binding]; other site 91891003058 membrane-bound complex binding site; other site 91891003059 hinge residues; other site 91891003060 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 91891003061 Soluble P-type ATPase [General function prediction only]; Region: COG4087 91891003062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 91891003063 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 91891003064 acyl-activating enzyme (AAE) consensus motif; other site 91891003065 AMP binding site [chemical binding]; other site 91891003066 active site 91891003067 CoA binding site [chemical binding]; other site 91891003068 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 91891003069 nucleoside/Zn binding site; other site 91891003070 dimer interface [polypeptide binding]; other site 91891003071 catalytic motif [active] 91891003072 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 91891003073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 91891003074 dimerization interface [polypeptide binding]; other site 91891003075 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 91891003076 cyclase homology domain; Region: CHD; cd07302 91891003077 nucleotidyl binding site; other site 91891003078 metal binding site [ion binding]; metal-binding site 91891003079 dimer interface [polypeptide binding]; other site 91891003080 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 91891003081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891003083 S-adenosylmethionine binding site [chemical binding]; other site 91891003084 Nitronate monooxygenase; Region: NMO; pfam03060 91891003085 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 91891003086 FMN binding site [chemical binding]; other site 91891003087 substrate binding site [chemical binding]; other site 91891003088 putative catalytic residue [active] 91891003089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 91891003090 COQ9; Region: COQ9; pfam08511 91891003091 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 91891003092 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 91891003093 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 91891003094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 91891003095 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 91891003096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891003097 dimer interface [polypeptide binding]; other site 91891003098 conserved gate region; other site 91891003099 putative PBP binding loops; other site 91891003100 ABC-ATPase subunit interface; other site 91891003101 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 91891003102 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 91891003103 Walker A/P-loop; other site 91891003104 ATP binding site [chemical binding]; other site 91891003105 Q-loop/lid; other site 91891003106 ABC transporter signature motif; other site 91891003107 Walker B; other site 91891003108 D-loop; other site 91891003109 H-loop/switch region; other site 91891003110 TOBE domain; Region: TOBE_2; pfam08402 91891003111 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 91891003112 GIY-YIG motif/motif A; other site 91891003113 putative active site [active] 91891003114 putative metal binding site [ion binding]; other site 91891003115 short chain dehydrogenase; Provisional; Region: PRK08219 91891003116 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 91891003117 NADP binding site [chemical binding]; other site 91891003118 active site 91891003119 steroid binding site; other site 91891003120 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 91891003121 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 91891003122 active site 91891003123 Zn binding site [ion binding]; other site 91891003124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891003125 Coenzyme A binding pocket [chemical binding]; other site 91891003126 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 91891003127 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 91891003128 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 91891003129 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 91891003130 DNA binding site [nucleotide binding] 91891003131 active site 91891003132 probable polyamine oxidase; Region: PLN02268 91891003133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 91891003134 pyruvate decarboxylase; Region: PLN02573 91891003135 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 91891003136 dimer interface [polypeptide binding]; other site 91891003137 PYR/PP interface [polypeptide binding]; other site 91891003138 TPP binding site [chemical binding]; other site 91891003139 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 91891003140 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 91891003141 TPP-binding site [chemical binding]; other site 91891003142 dimer interface [polypeptide binding]; other site 91891003143 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 91891003144 Peptidase family M28; Region: Peptidase_M28; pfam04389 91891003145 metal binding site [ion binding]; metal-binding site 91891003146 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 91891003147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891003148 nucleophilic elbow; other site 91891003149 catalytic triad; other site 91891003150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891003151 active site 91891003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003153 metabolite-proton symporter; Region: 2A0106; TIGR00883 91891003154 putative substrate translocation pore; other site 91891003155 acetylornithine deacetylase; Provisional; Region: PRK07522 91891003156 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 91891003157 metal binding site [ion binding]; metal-binding site 91891003158 putative dimer interface [polypeptide binding]; other site 91891003159 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 91891003160 7kD viral coat protein; Region: 7kD_coat; pfam02495 91891003161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 91891003162 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 91891003163 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891003164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891003165 metal binding site [ion binding]; metal-binding site 91891003166 active site 91891003167 I-site; other site 91891003168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891003169 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 91891003170 putative ligand binding pocket/active site [active] 91891003171 putative metal binding site [ion binding]; other site 91891003172 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 91891003173 AMMECR1; Region: AMMECR1; pfam01871 91891003174 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 91891003175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891003176 FeS/SAM binding site; other site 91891003177 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891003178 Sel1-like repeats; Region: SEL1; smart00671 91891003179 Sel1-like repeats; Region: SEL1; smart00671 91891003180 Sel1-like repeats; Region: SEL1; smart00671 91891003181 Sel1-like repeats; Region: SEL1; smart00671 91891003182 Sel1-like repeats; Region: SEL1; smart00671 91891003183 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891003184 Sel1-like repeats; Region: SEL1; smart00671 91891003185 Sel1-like repeats; Region: SEL1; smart00671 91891003186 Sel1-like repeats; Region: SEL1; smart00671 91891003187 Sel1-like repeats; Region: SEL1; smart00671 91891003188 Sel1-like repeats; Region: SEL1; smart00671 91891003189 Sel1-like repeats; Region: SEL1; smart00671 91891003190 Sel1-like repeats; Region: SEL1; smart00671 91891003191 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 91891003192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891003193 dimer interface [polypeptide binding]; other site 91891003194 phosphorylation site [posttranslational modification] 91891003195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891003196 ATP binding site [chemical binding]; other site 91891003197 Mg2+ binding site [ion binding]; other site 91891003198 G-X-G motif; other site 91891003199 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 91891003200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891003201 active site 91891003202 phosphorylation site [posttranslational modification] 91891003203 intermolecular recognition site; other site 91891003204 dimerization interface [polypeptide binding]; other site 91891003205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891003206 Walker A motif; other site 91891003207 ATP binding site [chemical binding]; other site 91891003208 Walker B motif; other site 91891003209 arginine finger; other site 91891003210 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 91891003211 AsnC family; Region: AsnC_trans_reg; pfam01037 91891003212 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891003213 Peptidase family M48; Region: Peptidase_M48; pfam01435 91891003214 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 91891003215 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 91891003216 catalytic motif [active] 91891003217 Zn binding site [ion binding]; other site 91891003218 RibD C-terminal domain; Region: RibD_C; cl17279 91891003219 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 91891003220 Lumazine binding domain; Region: Lum_binding; pfam00677 91891003221 Lumazine binding domain; Region: Lum_binding; pfam00677 91891003222 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 91891003223 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 91891003224 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 91891003225 dimerization interface [polypeptide binding]; other site 91891003226 active site 91891003227 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 91891003228 homopentamer interface [polypeptide binding]; other site 91891003229 active site 91891003230 CTP synthetase; Validated; Region: pyrG; PRK05380 91891003231 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 91891003232 Catalytic site [active] 91891003233 active site 91891003234 UTP binding site [chemical binding]; other site 91891003235 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 91891003236 active site 91891003237 putative oxyanion hole; other site 91891003238 catalytic triad [active] 91891003239 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 91891003240 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 91891003241 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 91891003242 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 91891003243 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 91891003244 Putative exonuclease, RdgC; Region: RdgC; pfam04381 91891003245 K+ potassium transporter; Region: K_trans; pfam02705 91891003246 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 91891003247 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 91891003248 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 91891003249 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 91891003250 putative RNA binding site [nucleotide binding]; other site 91891003251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891003252 S-adenosylmethionine binding site [chemical binding]; other site 91891003253 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 91891003254 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 91891003255 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 91891003256 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 91891003257 conserved cys residue [active] 91891003258 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 91891003259 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 91891003260 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 91891003261 metal binding site [ion binding]; metal-binding site 91891003262 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 91891003263 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 91891003264 substrate binding site [chemical binding]; other site 91891003265 glutamase interaction surface [polypeptide binding]; other site 91891003266 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 91891003267 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 91891003268 catalytic residues [active] 91891003269 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 91891003270 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 91891003271 putative active site [active] 91891003272 oxyanion strand; other site 91891003273 catalytic triad [active] 91891003274 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 91891003275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891003276 active site 91891003277 motif I; other site 91891003278 motif II; other site 91891003279 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 91891003280 putative active site pocket [active] 91891003281 4-fold oligomerization interface [polypeptide binding]; other site 91891003282 metal binding residues [ion binding]; metal-binding site 91891003283 3-fold/trimer interface [polypeptide binding]; other site 91891003284 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 91891003285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 91891003286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891003287 homodimer interface [polypeptide binding]; other site 91891003288 catalytic residue [active] 91891003289 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 91891003290 histidinol dehydrogenase; Region: hisD; TIGR00069 91891003291 NAD binding site [chemical binding]; other site 91891003292 dimerization interface [polypeptide binding]; other site 91891003293 product binding site; other site 91891003294 substrate binding site [chemical binding]; other site 91891003295 zinc binding site [ion binding]; other site 91891003296 catalytic residues [active] 91891003297 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 91891003298 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 91891003299 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 91891003300 Trp repressor protein; Region: Trp_repressor; cl17266 91891003301 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 91891003302 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 91891003303 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 91891003304 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 91891003305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891003306 active site 91891003307 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891003308 DNA-binding site [nucleotide binding]; DNA binding site 91891003309 RNA-binding motif; other site 91891003310 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 91891003311 30S subunit binding site; other site 91891003312 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 91891003313 putative deacylase active site [active] 91891003314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 91891003315 MarR family; Region: MarR_2; pfam12802 91891003316 MarR family; Region: MarR_2; cl17246 91891003317 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 91891003318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 91891003319 LysE type translocator; Region: LysE; cl00565 91891003320 Transcriptional regulators [Transcription]; Region: MarR; COG1846 91891003321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891003322 Coenzyme A binding pocket [chemical binding]; other site 91891003323 Predicted ATPase [General function prediction only]; Region: COG3911 91891003324 AAA domain; Region: AAA_28; pfam13521 91891003325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891003326 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 91891003327 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 91891003328 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12619 91891003329 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 91891003330 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12628 91891003331 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 91891003332 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634 91891003333 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 91891003334 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 91891003335 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 91891003336 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 91891003337 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 91891003338 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 91891003339 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 91891003340 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 91891003341 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 91891003342 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 91891003343 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 91891003344 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12701 91891003345 Flagellar L-ring protein; Region: FlgH; pfam02107 91891003346 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 91891003347 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 91891003348 Rod binding protein; Region: Rod-binding; cl01626 91891003349 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12710 91891003350 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 91891003351 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12715 91891003352 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 91891003353 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 91891003354 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 91891003355 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 91891003356 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 91891003357 active site 91891003358 nucleophile elbow; other site 91891003359 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 91891003360 Helix-turn-helix domain; Region: HTH_38; pfam13936 91891003361 Homeodomain-like domain; Region: HTH_32; pfam13565 91891003362 Integrase core domain; Region: rve; pfam00665 91891003363 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 91891003364 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 91891003365 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 91891003366 transmembrane helices; other site 91891003367 TrkA-C domain; Region: TrkA_C; pfam02080 91891003368 TrkA-C domain; Region: TrkA_C; pfam02080 91891003369 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 91891003370 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 91891003371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 91891003372 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 91891003373 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 91891003374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 91891003375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891003376 Walker A/P-loop; other site 91891003377 ATP binding site [chemical binding]; other site 91891003378 Q-loop/lid; other site 91891003379 ABC transporter signature motif; other site 91891003380 Walker B; other site 91891003381 D-loop; other site 91891003382 H-loop/switch region; other site 91891003383 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 91891003384 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 91891003385 malate dehydrogenase; Provisional; Region: PRK13529 91891003386 Malic enzyme, N-terminal domain; Region: malic; pfam00390 91891003387 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 91891003388 NAD(P) binding site [chemical binding]; other site 91891003389 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 91891003390 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891003391 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 91891003392 Peptidase family M23; Region: Peptidase_M23; pfam01551 91891003393 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 91891003394 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 91891003395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 91891003396 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 91891003397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 91891003398 DNA binding residues [nucleotide binding] 91891003399 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 91891003400 hypothetical protein; Validated; Region: PRK00110 91891003401 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 91891003402 active site 91891003403 putative DNA-binding cleft [nucleotide binding]; other site 91891003404 dimer interface [polypeptide binding]; other site 91891003405 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 91891003406 RuvA N terminal domain; Region: RuvA_N; pfam01330 91891003407 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 91891003408 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 91891003409 sensor protein QseC; Provisional; Region: PRK10337 91891003410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891003411 dimer interface [polypeptide binding]; other site 91891003412 phosphorylation site [posttranslational modification] 91891003413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891003414 ATP binding site [chemical binding]; other site 91891003415 Mg2+ binding site [ion binding]; other site 91891003416 G-X-G motif; other site 91891003417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891003418 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 91891003419 active site 91891003420 phosphorylation site [posttranslational modification] 91891003421 intermolecular recognition site; other site 91891003422 dimerization interface [polypeptide binding]; other site 91891003423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 91891003424 DNA binding site [nucleotide binding] 91891003425 intracellular septation protein A; Reviewed; Region: PRK00259 91891003426 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 91891003427 N-acetyl-D-glucosamine binding site [chemical binding]; other site 91891003428 catalytic residue [active] 91891003429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891003430 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891003431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891003432 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 91891003433 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 91891003434 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 91891003435 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 91891003436 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 91891003437 homodimer interface [polypeptide binding]; other site 91891003438 NADP binding site [chemical binding]; other site 91891003439 substrate binding site [chemical binding]; other site 91891003440 FimV N-terminal domain; Region: FimV_core; TIGR03505 91891003441 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 91891003442 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 91891003443 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 91891003444 NADH(P)-binding; Region: NAD_binding_10; pfam13460 91891003445 putative NAD(P) binding site [chemical binding]; other site 91891003446 active site 91891003447 DoxX-like family; Region: DoxX_3; pfam13781 91891003448 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 91891003449 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 91891003450 dimerization interface 3.5A [polypeptide binding]; other site 91891003451 active site 91891003452 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 91891003453 active site 91891003454 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 91891003455 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 91891003456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891003457 catalytic residue [active] 91891003458 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 91891003459 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 91891003460 substrate binding site [chemical binding]; other site 91891003461 active site 91891003462 catalytic residues [active] 91891003463 heterodimer interface [polypeptide binding]; other site 91891003464 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 91891003465 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 91891003466 active site 91891003467 HIGH motif; other site 91891003468 nucleotide binding site [chemical binding]; other site 91891003469 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 91891003470 KMSKS motif; other site 91891003471 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 91891003472 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 91891003473 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 91891003474 active site 91891003475 HIGH motif; other site 91891003476 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 91891003477 KMSKS motif; other site 91891003478 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 91891003479 tRNA binding surface [nucleotide binding]; other site 91891003480 anticodon binding site; other site 91891003481 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 91891003482 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 91891003483 Sulfatase; Region: Sulfatase; pfam00884 91891003484 type II secretion system protein E; Region: type_II_gspE; TIGR02533 91891003485 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 91891003486 Walker A motif; other site 91891003487 ATP binding site [chemical binding]; other site 91891003488 Walker B motif; other site 91891003489 Sporulation related domain; Region: SPOR; pfam05036 91891003490 type II secretion system protein D; Region: type_II_gspD; TIGR02517 91891003491 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 91891003492 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 91891003493 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 91891003494 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 91891003495 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 91891003496 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 91891003497 Cache domain; Region: Cache_1; pfam02743 91891003498 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 91891003499 cyclase homology domain; Region: CHD; cd07302 91891003500 nucleotidyl binding site; other site 91891003501 metal binding site [ion binding]; metal-binding site 91891003502 dimer interface [polypeptide binding]; other site 91891003503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003504 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 91891003505 putative substrate translocation pore; other site 91891003506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891003508 putative substrate translocation pore; other site 91891003509 IucA / IucC family; Region: IucA_IucC; pfam04183 91891003510 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 91891003511 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 91891003512 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 91891003513 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 91891003514 Evidence 4 : Homologs of previously reported genes of unknown function 91891003515 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pcp : putative cell process 91891003516 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 91891003517 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 91891003518 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 91891003519 protein binding site [polypeptide binding]; other site 91891003520 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 91891003521 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 91891003522 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 91891003523 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 91891003524 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 91891003525 RNA binding surface [nucleotide binding]; other site 91891003526 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 91891003527 active site 91891003528 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 91891003529 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 91891003530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891003531 FeS/SAM binding site; other site 91891003532 TRAM domain; Region: TRAM; pfam01938 91891003533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003534 putative substrate translocation pore; other site 91891003535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891003536 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891003537 Flagellar protein FliS; Region: FliS; cl00654 91891003538 flagellar capping protein; Provisional; Region: PRK12765 91891003539 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 91891003540 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 91891003541 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 91891003542 flagellin; Provisional; Region: PRK12806 91891003543 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 91891003544 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 91891003545 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 91891003546 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 91891003547 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 91891003548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 91891003549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 91891003550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 91891003551 Sporulation related domain; Region: SPOR; pfam05036 91891003552 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 91891003553 Colicin V production protein; Region: Colicin_V; pfam02674 91891003554 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 91891003555 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 91891003556 active site 91891003557 (T/H)XGH motif; other site 91891003558 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 91891003559 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 91891003560 Lipopolysaccharide-assembly; Region: LptE; cl01125 91891003561 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 91891003562 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 91891003563 HIGH motif; other site 91891003564 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 91891003565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 91891003566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 91891003567 active site 91891003568 KMSKS motif; other site 91891003569 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 91891003570 tRNA binding surface [nucleotide binding]; other site 91891003571 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 91891003572 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 91891003573 putative active site [active] 91891003574 catalytic triad [active] 91891003575 putative dimer interface [polypeptide binding]; other site 91891003576 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 91891003577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891003578 aldehyde dehydrogenase family 7 member; Region: PLN02315 91891003579 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 91891003580 tetrameric interface [polypeptide binding]; other site 91891003581 NAD binding site [chemical binding]; other site 91891003582 catalytic residues [active] 91891003583 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 91891003584 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 91891003585 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 91891003586 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 91891003587 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 91891003588 substrate binding site [chemical binding]; other site 91891003589 oxyanion hole (OAH) forming residues; other site 91891003590 trimer interface [polypeptide binding]; other site 91891003591 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 91891003592 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 91891003593 dimer interface [polypeptide binding]; other site 91891003594 active site 91891003595 DNA-directed RNA polymerase subunit A''; Validated; Region: PRK04309 91891003596 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891003597 Sel1-like repeats; Region: SEL1; smart00671 91891003598 Sel1-like repeats; Region: SEL1; smart00671 91891003599 Sel1-like repeats; Region: SEL1; smart00671 91891003600 Sel1-like repeats; Region: SEL1; smart00671 91891003601 Sel1-like repeats; Region: SEL1; smart00671 91891003602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891003603 PAS domain; Region: PAS_9; pfam13426 91891003604 putative active site [active] 91891003605 heme pocket [chemical binding]; other site 91891003606 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891003607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891003608 metal binding site [ion binding]; metal-binding site 91891003609 active site 91891003610 I-site; other site 91891003611 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891003612 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 91891003613 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 91891003614 type II secretion system protein J; Region: gspJ; TIGR01711 91891003615 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 91891003616 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 91891003617 Type II transport protein GspH; Region: GspH; pfam12019 91891003618 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 91891003619 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 91891003620 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 91891003621 type II secretion system protein F; Region: GspF; TIGR02120 91891003622 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 91891003623 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 91891003624 glutamine synthetase; Provisional; Region: glnA; PRK09469 91891003625 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 91891003626 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 91891003627 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 91891003628 hypothetical protein; Validated; Region: PRK02101 91891003629 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 91891003630 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 91891003631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891003632 catalytic residue [active] 91891003633 heat shock protein 90; Provisional; Region: PRK05218 91891003634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891003635 ATP binding site [chemical binding]; other site 91891003636 Mg2+ binding site [ion binding]; other site 91891003637 G-X-G motif; other site 91891003638 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 91891003639 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 91891003640 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 91891003641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 91891003642 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 91891003643 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 91891003644 RNA/DNA hybrid binding site [nucleotide binding]; other site 91891003645 active site 91891003646 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 91891003647 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 91891003648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 91891003649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 91891003650 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 91891003651 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 91891003652 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 91891003653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003654 urocanate hydratase; Provisional; Region: PRK05414 91891003655 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 91891003656 active sites [active] 91891003657 tetramer interface [polypeptide binding]; other site 91891003658 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 91891003659 NAD(P) binding site [chemical binding]; other site 91891003660 catalytic residues [active] 91891003661 short chain dehydrogenase; Provisional; Region: PRK08278 91891003662 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 91891003663 NAD(P) binding site [chemical binding]; other site 91891003664 homodimer interface [polypeptide binding]; other site 91891003665 active site 91891003666 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 91891003667 RNA/DNA hybrid binding site [nucleotide binding]; other site 91891003668 active site 91891003669 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 91891003670 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 91891003671 active site 91891003672 catalytic site [active] 91891003673 substrate binding site [chemical binding]; other site 91891003674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 91891003675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891003676 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 91891003677 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 91891003678 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 91891003679 Ligand Binding Site [chemical binding]; other site 91891003680 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 91891003681 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 91891003682 putative phosphate acyltransferase; Provisional; Region: PRK05331 91891003683 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 91891003684 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 91891003685 dimer interface [polypeptide binding]; other site 91891003686 active site 91891003687 CoA binding pocket [chemical binding]; other site 91891003688 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 91891003689 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 91891003690 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 91891003691 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 91891003692 NAD(P) binding site [chemical binding]; other site 91891003693 homotetramer interface [polypeptide binding]; other site 91891003694 homodimer interface [polypeptide binding]; other site 91891003695 active site 91891003696 acyl carrier protein; Provisional; Region: acpP; PRK00982 91891003697 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 91891003698 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 91891003699 dimer interface [polypeptide binding]; other site 91891003700 active site 91891003701 YceG-like family; Region: YceG; pfam02618 91891003702 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 91891003703 dimerization interface [polypeptide binding]; other site 91891003704 thymidylate kinase; Validated; Region: tmk; PRK00698 91891003705 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 91891003706 TMP-binding site; other site 91891003707 ATP-binding site [chemical binding]; other site 91891003708 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 91891003709 DNA polymerase III subunit delta'; Validated; Region: PRK08485 91891003710 PilZ domain; Region: PilZ; cl01260 91891003711 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 91891003712 active site 91891003713 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 91891003714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891003715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003716 putative substrate translocation pore; other site 91891003717 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 91891003718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003719 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 91891003720 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 91891003721 Ligand binding site; other site 91891003722 Putative Catalytic site; other site 91891003723 DXD motif; other site 91891003724 Predicted membrane protein [Function unknown]; Region: COG2246 91891003725 GtrA-like protein; Region: GtrA; pfam04138 91891003726 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 91891003727 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 91891003728 Phosphotransferase enzyme family; Region: APH; pfam01636 91891003729 active site 91891003730 ATP binding site [chemical binding]; other site 91891003731 substrate binding site [chemical binding]; other site 91891003732 dimer interface [polypeptide binding]; other site 91891003733 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 91891003734 active site 91891003735 catalytic site [active] 91891003736 substrate binding site [chemical binding]; other site 91891003737 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 91891003738 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 91891003739 N-acetyl-D-glucosamine binding site [chemical binding]; other site 91891003740 catalytic residue [active] 91891003741 adenylate kinase; Reviewed; Region: adk; PRK00279 91891003742 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 91891003743 AMP-binding site [chemical binding]; other site 91891003744 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 91891003745 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 91891003746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 91891003747 catalytic residues [active] 91891003748 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 91891003749 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 91891003750 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 91891003751 N- and C-terminal domain interface [polypeptide binding]; other site 91891003752 active site 91891003753 MgATP binding site [chemical binding]; other site 91891003754 catalytic site [active] 91891003755 metal binding site [ion binding]; metal-binding site 91891003756 glycerol binding site [chemical binding]; other site 91891003757 homotetramer interface [polypeptide binding]; other site 91891003758 homodimer interface [polypeptide binding]; other site 91891003759 FBP binding site [chemical binding]; other site 91891003760 protein IIAGlc interface [polypeptide binding]; other site 91891003761 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 91891003762 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 91891003763 dimer interface [polypeptide binding]; other site 91891003764 active site 91891003765 citrylCoA binding site [chemical binding]; other site 91891003766 NADH binding [chemical binding]; other site 91891003767 cationic pore residues; other site 91891003768 oxalacetate/citrate binding site [chemical binding]; other site 91891003769 coenzyme A binding site [chemical binding]; other site 91891003770 catalytic triad [active] 91891003771 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 91891003772 DNA gyrase subunit A; Validated; Region: PRK05560 91891003773 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 91891003774 CAP-like domain; other site 91891003775 active site 91891003776 primary dimer interface [polypeptide binding]; other site 91891003777 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 91891003778 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 91891003779 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 91891003780 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 91891003781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 91891003782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 91891003783 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 91891003784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891003785 catalytic residue [active] 91891003786 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 91891003787 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 91891003788 hinge; other site 91891003789 active site 91891003790 cytidylate kinase; Provisional; Region: cmk; PRK00023 91891003791 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 91891003792 CMP-binding site; other site 91891003793 The sites determining sugar specificity; other site 91891003794 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 91891003795 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 91891003796 RNA binding site [nucleotide binding]; other site 91891003797 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 91891003798 RNA binding site [nucleotide binding]; other site 91891003799 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 91891003800 RNA binding site [nucleotide binding]; other site 91891003801 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 91891003802 RNA binding site [nucleotide binding]; other site 91891003803 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 91891003804 RNA binding site [nucleotide binding]; other site 91891003805 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 91891003806 RNA binding site [nucleotide binding]; other site 91891003807 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 91891003808 tetratricopeptide repeat protein; Provisional; Region: PRK11788 91891003809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891003810 TPR motif; other site 91891003811 binding surface 91891003812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 91891003813 binding surface 91891003814 TPR motif; other site 91891003815 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 91891003816 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 91891003817 inhibitor-cofactor binding pocket; inhibition site 91891003818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891003819 catalytic residue [active] 91891003820 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 91891003821 active site 91891003822 dimer interface [polypeptide binding]; other site 91891003823 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 91891003824 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 91891003825 active site 91891003826 nucleophile elbow; other site 91891003827 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 91891003828 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891003829 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891003830 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 91891003831 Chorismate lyase; Region: Chor_lyase; cl01230 91891003832 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 91891003833 UbiA prenyltransferase family; Region: UbiA; pfam01040 91891003834 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 91891003835 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 91891003836 FAD binding domain; Region: FAD_binding_4; pfam01565 91891003837 Berberine and berberine like; Region: BBE; pfam08031 91891003838 Class I aldolases; Region: Aldolase_Class_I; cl17187 91891003839 catalytic residue [active] 91891003840 purine nucleoside phosphorylase; Provisional; Region: PRK08202 91891003841 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 91891003842 active site 91891003843 catalytic motif [active] 91891003844 Zn binding site [ion binding]; other site 91891003845 two-component sensor protein; Provisional; Region: cpxA; PRK09470 91891003846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 91891003847 dimerization interface [polypeptide binding]; other site 91891003848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891003849 dimer interface [polypeptide binding]; other site 91891003850 phosphorylation site [posttranslational modification] 91891003851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891003852 ATP binding site [chemical binding]; other site 91891003853 Mg2+ binding site [ion binding]; other site 91891003854 G-X-G motif; other site 91891003855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891003856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 91891003857 active site 91891003858 phosphorylation site [posttranslational modification] 91891003859 intermolecular recognition site; other site 91891003860 dimerization interface [polypeptide binding]; other site 91891003861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 91891003862 DNA binding site [nucleotide binding] 91891003863 FOG: CBS domain [General function prediction only]; Region: COG0517 91891003864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 91891003865 Transporter associated domain; Region: CorC_HlyC; smart01091 91891003866 metal-binding heat shock protein; Provisional; Region: PRK00016 91891003867 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 91891003868 PhoH-like protein; Region: PhoH; pfam02562 91891003869 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 91891003870 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 91891003871 active site 91891003872 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 91891003873 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 91891003874 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 91891003875 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 91891003876 active site 91891003877 HIGH motif; other site 91891003878 dimer interface [polypeptide binding]; other site 91891003879 KMSKS motif; other site 91891003880 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 91891003881 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 91891003882 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 91891003883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 91891003884 RNA binding surface [nucleotide binding]; other site 91891003885 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 91891003886 probable active site [active] 91891003887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 91891003888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 91891003889 DNA binding residues [nucleotide binding] 91891003890 dimerization interface [polypeptide binding]; other site 91891003891 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 91891003892 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 91891003893 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 91891003894 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 91891003895 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 91891003896 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 91891003897 substrate binding site [chemical binding]; other site 91891003898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891003899 putative transporter; Provisional; Region: PRK10504 91891003900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003901 putative substrate translocation pore; other site 91891003902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891003903 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 91891003904 TRAM domain; Region: TRAM; pfam01938 91891003905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891003906 S-adenosylmethionine binding site [chemical binding]; other site 91891003907 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 91891003908 HD domain; Region: HD_4; pfam13328 91891003909 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 91891003910 synthetase active site [active] 91891003911 NTP binding site [chemical binding]; other site 91891003912 metal binding site [ion binding]; metal-binding site 91891003913 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 91891003914 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 91891003915 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 91891003916 aminotransferase; Validated; Region: PRK08175 91891003917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 91891003918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891003919 homodimer interface [polypeptide binding]; other site 91891003920 catalytic residue [active] 91891003921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 91891003922 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 91891003923 DHH family; Region: DHH; pfam01368 91891003924 DHHA1 domain; Region: DHHA1; pfam02272 91891003925 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 91891003926 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 91891003927 FMN binding site [chemical binding]; other site 91891003928 active site 91891003929 catalytic residues [active] 91891003930 substrate binding site [chemical binding]; other site 91891003931 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13104 91891003932 DEAD/DEAH box helicase; Region: DEAD; pfam00270 91891003933 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 91891003934 SEC-C motif; Region: SEC-C; pfam02810 91891003935 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 91891003936 active site 91891003937 8-oxo-dGMP binding site [chemical binding]; other site 91891003938 nudix motif; other site 91891003939 metal binding site [ion binding]; metal-binding site 91891003940 putative transposase OrfB; Reviewed; Region: PHA02517 91891003941 Integrase core domain; Region: rve; pfam00665 91891003942 Integrase core domain; Region: rve_3; pfam13683 91891003943 Evidence 4 : Homologs of previously reported genes of unknown function 91891003944 hypothetical protein; Provisional; Region: PRK05287 91891003945 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 91891003946 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 91891003947 CoA-binding site [chemical binding]; other site 91891003948 ATP-binding [chemical binding]; other site 91891003949 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891003950 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 91891003951 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 91891003952 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 91891003953 inhibitor-cofactor binding pocket; inhibition site 91891003954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891003955 catalytic residue [active] 91891003956 biotin synthase; Region: bioB; TIGR00433 91891003957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891003958 FeS/SAM binding site; other site 91891003959 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 91891003960 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 91891003961 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 91891003962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891003963 catalytic residue [active] 91891003964 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 91891003965 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 91891003966 AAA domain; Region: AAA_26; pfam13500 91891003967 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 91891003968 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 91891003969 Uncharacterized conserved protein [Function unknown]; Region: COG2928 91891003970 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 91891003971 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 91891003972 dimer interface [polypeptide binding]; other site 91891003973 anticodon binding site; other site 91891003974 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 91891003975 homodimer interface [polypeptide binding]; other site 91891003976 motif 1; other site 91891003977 active site 91891003978 motif 2; other site 91891003979 GAD domain; Region: GAD; pfam02938 91891003980 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 91891003981 motif 3; other site 91891003982 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 91891003983 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 91891003984 Mechanosensitive ion channel; Region: MS_channel; pfam00924 91891003985 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 91891003986 putative DNA-binding cleft [nucleotide binding]; other site 91891003987 putative DNA clevage site; other site 91891003988 molecular lever; other site 91891003989 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 91891003990 Catalytic domain of Protein Kinases; Region: PKc; cd00180 91891003991 active site 91891003992 ATP binding site [chemical binding]; other site 91891003993 substrate binding site [chemical binding]; other site 91891003994 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 91891003995 substrate binding site [chemical binding]; other site 91891003996 activation loop (A-loop); other site 91891003997 activation loop (A-loop); other site 91891003998 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 91891003999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 91891004000 putative DNA binding site [nucleotide binding]; other site 91891004001 putative Zn2+ binding site [ion binding]; other site 91891004002 AsnC family; Region: AsnC_trans_reg; pfam01037 91891004003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891004004 Coenzyme A binding pocket [chemical binding]; other site 91891004005 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 91891004006 GAF domain; Region: GAF; pfam01590 91891004007 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 91891004008 cyclase homology domain; Region: CHD; cd07302 91891004009 nucleotidyl binding site; other site 91891004010 metal binding site [ion binding]; metal-binding site 91891004011 dimer interface [polypeptide binding]; other site 91891004012 Phosphotransferase enzyme family; Region: APH; pfam01636 91891004013 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 91891004014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 91891004015 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 91891004016 putative active site pocket [active] 91891004017 dimerization interface [polypeptide binding]; other site 91891004018 putative catalytic residue [active] 91891004019 Dot/Icm substrate protein; Region: SidE; pfam12252 91891004020 aminopeptidase N; Provisional; Region: pepN; PRK14015 91891004021 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 91891004022 Zn binding site [ion binding]; other site 91891004023 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891004024 putative transposase OrfB; Reviewed; Region: PHA02517 91891004025 Integrase core domain; Region: rve; pfam00665 91891004026 Integrase core domain; Region: rve_3; pfam13683 91891004027 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891004028 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 91891004029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 91891004030 Coenzyme A binding pocket [chemical binding]; other site 91891004031 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 91891004032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 91891004033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 91891004034 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 91891004035 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 91891004036 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 91891004037 E3 interaction surface; other site 91891004038 lipoyl attachment site [posttranslational modification]; other site 91891004039 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 91891004040 E3 interaction surface; other site 91891004041 lipoyl attachment site [posttranslational modification]; other site 91891004042 e3 binding domain; Region: E3_binding; pfam02817 91891004043 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 91891004044 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 91891004045 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 91891004046 dimer interface [polypeptide binding]; other site 91891004047 TPP-binding site [chemical binding]; other site 91891004048 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 91891004049 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 91891004050 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 91891004051 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 91891004052 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 91891004053 Sporulation related domain; Region: SPOR; pfam05036 91891004054 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 91891004055 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 91891004056 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 91891004057 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 91891004058 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 91891004059 homodimer interface [polypeptide binding]; other site 91891004060 substrate-cofactor binding pocket; other site 91891004061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891004062 catalytic residue [active] 91891004063 Protein of unknown function (DUF493); Region: DUF493; pfam04359 91891004064 lipoate-protein ligase B; Provisional; Region: PRK14342 91891004065 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 91891004066 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 91891004067 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 91891004068 active site 91891004069 LssY C-terminus; Region: LssY_C; pfam14067 91891004070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 91891004071 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 91891004072 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 91891004073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 91891004074 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 91891004075 Walker A/P-loop; other site 91891004076 ATP binding site [chemical binding]; other site 91891004077 Q-loop/lid; other site 91891004078 ABC transporter signature motif; other site 91891004079 Walker B; other site 91891004080 D-loop; other site 91891004081 H-loop/switch region; other site 91891004082 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 91891004083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891004084 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891004085 PAS domain S-box; Region: sensory_box; TIGR00229 91891004086 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891004087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891004088 metal binding site [ion binding]; metal-binding site 91891004089 active site 91891004090 I-site; other site 91891004091 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891004092 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891004093 active site 91891004094 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 91891004095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891004096 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 91891004097 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 91891004098 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 91891004099 Walker A motif; other site 91891004100 ATP binding site [chemical binding]; other site 91891004101 Walker B motif; other site 91891004102 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 91891004103 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 91891004104 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 91891004105 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 91891004106 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 91891004107 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 91891004108 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 91891004109 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 91891004110 ligand binding site [chemical binding]; other site 91891004111 CAAX protease self-immunity; Region: Abi; pfam02517 91891004112 PEP synthetase regulatory protein; Provisional; Region: PRK05339 91891004113 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 91891004114 2-methylcitrate dehydratase; Region: prpD; TIGR02330 91891004115 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 91891004116 dimer interface [polypeptide binding]; other site 91891004117 Citrate synthase; Region: Citrate_synt; pfam00285 91891004118 active site 91891004119 citrylCoA binding site [chemical binding]; other site 91891004120 oxalacetate/citrate binding site [chemical binding]; other site 91891004121 coenzyme A binding site [chemical binding]; other site 91891004122 catalytic triad [active] 91891004123 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 91891004124 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 91891004125 Uncharacterized conserved protein [Function unknown]; Region: COG4121 91891004126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 91891004127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004128 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 91891004129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004130 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 91891004131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 91891004132 inhibitor-cofactor binding pocket; inhibition site 91891004133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891004134 catalytic residue [active] 91891004135 Rubredoxin [Energy production and conversion]; Region: COG1773 91891004136 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 91891004137 iron binding site [ion binding]; other site 91891004138 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 91891004139 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 91891004140 poly(A) polymerase; Region: pcnB; TIGR01942 91891004141 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 91891004142 active site 91891004143 NTP binding site [chemical binding]; other site 91891004144 metal binding triad [ion binding]; metal-binding site 91891004145 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 91891004146 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 91891004147 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 91891004148 catalytic center binding site [active] 91891004149 ATP binding site [chemical binding]; other site 91891004150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 91891004151 Ligand Binding Site [chemical binding]; other site 91891004152 GTP-binding protein Der; Reviewed; Region: PRK00093 91891004153 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 91891004154 G1 box; other site 91891004155 GTP/Mg2+ binding site [chemical binding]; other site 91891004156 Switch I region; other site 91891004157 G2 box; other site 91891004158 Switch II region; other site 91891004159 G3 box; other site 91891004160 G4 box; other site 91891004161 G5 box; other site 91891004162 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 91891004163 G1 box; other site 91891004164 GTP/Mg2+ binding site [chemical binding]; other site 91891004165 Switch I region; other site 91891004166 G2 box; other site 91891004167 G3 box; other site 91891004168 Switch II region; other site 91891004169 G4 box; other site 91891004170 G5 box; other site 91891004171 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 91891004172 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 91891004173 Trp docking motif [polypeptide binding]; other site 91891004174 active site 91891004175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 91891004176 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 91891004177 histidyl-tRNA synthetase; Region: hisS; TIGR00442 91891004178 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 91891004179 dimer interface [polypeptide binding]; other site 91891004180 motif 1; other site 91891004181 active site 91891004182 motif 2; other site 91891004183 motif 3; other site 91891004184 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 91891004185 anticodon binding site; other site 91891004186 Helix-turn-helix domain; Region: HTH_25; pfam13413 91891004187 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 91891004188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891004189 binding surface 91891004190 TPR motif; other site 91891004191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891004192 binding surface 91891004193 TPR motif; other site 91891004194 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 91891004195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891004196 FeS/SAM binding site; other site 91891004197 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 91891004198 active site 91891004199 multimer interface [polypeptide binding]; other site 91891004200 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891004201 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891004202 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891004203 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891004204 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 91891004205 active site 91891004206 dinuclear metal binding site [ion binding]; other site 91891004207 dimerization interface [polypeptide binding]; other site 91891004208 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 91891004209 putative active site [active] 91891004210 putative metal binding site [ion binding]; other site 91891004211 septum formation inhibitor; Reviewed; Region: minC; PRK00339 91891004212 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 91891004213 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 91891004214 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 91891004215 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 91891004216 acyl-activating enzyme (AAE) consensus motif; other site 91891004217 putative AMP binding site [chemical binding]; other site 91891004218 putative active site [active] 91891004219 putative CoA binding site [chemical binding]; other site 91891004220 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 91891004221 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 91891004222 substrate binding pocket [chemical binding]; other site 91891004223 membrane-bound complex binding site; other site 91891004224 hinge residues; other site 91891004225 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 91891004226 putative active site [active] 91891004227 putative CoA binding site [chemical binding]; other site 91891004228 nudix motif; other site 91891004229 metal binding site [ion binding]; metal-binding site 91891004230 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 91891004231 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 91891004232 chorismate binding enzyme; Region: Chorismate_bind; cl10555 91891004233 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 91891004234 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 91891004235 TPP-binding site [chemical binding]; other site 91891004236 tetramer interface [polypeptide binding]; other site 91891004237 heterodimer interface [polypeptide binding]; other site 91891004238 phosphorylation loop region [posttranslational modification] 91891004239 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 91891004240 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 91891004241 alpha subunit interface [polypeptide binding]; other site 91891004242 TPP binding site [chemical binding]; other site 91891004243 heterodimer interface [polypeptide binding]; other site 91891004244 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 91891004245 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 91891004246 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 91891004247 E3 interaction surface; other site 91891004248 lipoyl attachment site [posttranslational modification]; other site 91891004249 e3 binding domain; Region: E3_binding; pfam02817 91891004250 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 91891004251 Mechanosensitive ion channel; Region: MS_channel; pfam00924 91891004252 Uncharacterized conserved protein [Function unknown]; Region: COG0398 91891004253 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 91891004254 mercuric reductase; Validated; Region: PRK06370 91891004255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 91891004256 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 91891004257 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_3; cd02434 91891004258 NMT1/THI5 like; Region: NMT1; pfam09084 91891004259 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 91891004260 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 91891004261 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 91891004262 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 91891004263 thiS-thiF/thiG interaction site; other site 91891004264 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 91891004265 ThiS interaction site; other site 91891004266 putative active site [active] 91891004267 tetramer interface [polypeptide binding]; other site 91891004268 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 91891004269 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 91891004270 dimer interface [polypeptide binding]; other site 91891004271 substrate binding site [chemical binding]; other site 91891004272 ATP binding site [chemical binding]; other site 91891004273 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 91891004274 thiamine phosphate binding site [chemical binding]; other site 91891004275 active site 91891004276 pyrophosphate binding site [ion binding]; other site 91891004277 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 91891004278 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 91891004279 ATP binding site [chemical binding]; other site 91891004280 substrate interface [chemical binding]; other site 91891004281 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 91891004282 active site residue [active] 91891004283 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 91891004284 active site 91891004285 Zn binding site [ion binding]; other site 91891004286 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 91891004287 TolB amino-terminal domain; Region: TolB_N; pfam04052 91891004288 Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042 91891004289 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 91891004290 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 91891004291 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 91891004292 TolA protein; Region: tolA_full; TIGR02794 91891004293 TolA protein; Region: tolA_full; TIGR02794 91891004294 TonB C terminal; Region: TonB_2; pfam13103 91891004295 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 91891004296 TolR protein; Region: tolR; TIGR02801 91891004297 TolQ protein; Region: tolQ; TIGR02796 91891004298 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 91891004299 active site 91891004300 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 91891004301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891004302 Walker A motif; other site 91891004303 ATP binding site [chemical binding]; other site 91891004304 Walker B motif; other site 91891004305 arginine finger; other site 91891004306 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 91891004307 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 91891004308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 91891004309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 91891004310 DNA binding residues [nucleotide binding] 91891004311 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 91891004312 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 91891004313 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 91891004314 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 91891004315 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 91891004316 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 91891004317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 91891004318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891004319 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 91891004320 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 91891004321 NAD(P) binding site [chemical binding]; other site 91891004322 catalytic residues [active] 91891004323 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 91891004324 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 91891004325 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 91891004326 putative catalytic residue [active] 91891004327 chromosome segregation protein; Provisional; Region: PRK03918 91891004328 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 91891004329 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 91891004330 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 91891004331 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 91891004332 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 91891004333 Global regulator protein family; Region: CsrA; pfam02599 91891004334 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 91891004335 active site 91891004336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 91891004337 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891004338 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 91891004339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 91891004340 substrate binding site [chemical binding]; other site 91891004341 oxyanion hole (OAH) forming residues; other site 91891004342 trimer interface [polypeptide binding]; other site 91891004343 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 91891004344 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 91891004345 acetyl-CoA acetyltransferase; Provisional; Region: PRK08170 91891004346 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 91891004347 dimer interface [polypeptide binding]; other site 91891004348 active site 91891004349 integrase; Provisional; Region: int; PHA02601 91891004350 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 91891004351 active site 91891004352 DNA binding site [nucleotide binding] 91891004353 Int/Topo IB signature motif; other site 91891004354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891004355 Coenzyme A binding pocket [chemical binding]; other site 91891004356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004357 metabolite-proton symporter; Region: 2A0106; TIGR00883 91891004358 putative substrate translocation pore; other site 91891004359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891004360 Coenzyme A binding pocket [chemical binding]; other site 91891004361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891004362 Serine hydrolase; Region: Ser_hydrolase; cl17834 91891004363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 91891004364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 91891004365 DNA binding residues [nucleotide binding] 91891004366 dimerization interface [polypeptide binding]; other site 91891004367 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891004368 DNA-binding site [nucleotide binding]; DNA binding site 91891004369 RNA-binding motif; other site 91891004370 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 91891004371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891004372 NAD(P) binding site [chemical binding]; other site 91891004373 active site 91891004374 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 91891004375 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 91891004376 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 91891004377 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891004378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891004379 metal binding site [ion binding]; metal-binding site 91891004380 active site 91891004381 I-site; other site 91891004382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891004383 Heme NO binding; Region: HNOB; pfam07700 91891004384 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 91891004385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891004386 non-specific DNA binding site [nucleotide binding]; other site 91891004387 salt bridge; other site 91891004388 sequence-specific DNA binding site [nucleotide binding]; other site 91891004389 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 91891004390 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 91891004391 alpha subunit interaction interface [polypeptide binding]; other site 91891004392 Walker A motif; other site 91891004393 ATP binding site [chemical binding]; other site 91891004394 Walker B motif; other site 91891004395 inhibitor binding site; inhibition site 91891004396 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 91891004397 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 91891004398 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 91891004399 gamma subunit interface [polypeptide binding]; other site 91891004400 epsilon subunit interface [polypeptide binding]; other site 91891004401 LBP interface [polypeptide binding]; other site 91891004402 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 91891004403 F0F1 ATP synthase subunit A; Provisional; Region: PRK13420 91891004404 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 91891004405 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 91891004406 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 91891004407 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 91891004408 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891004409 Walker A motif; other site 91891004410 ATP binding site [chemical binding]; other site 91891004411 Walker B motif; other site 91891004412 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 91891004413 core domain interface [polypeptide binding]; other site 91891004414 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 91891004415 delta subunit interface [polypeptide binding]; other site 91891004416 epsilon subunit interface [polypeptide binding]; other site 91891004417 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 91891004418 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 91891004419 FAD binding pocket [chemical binding]; other site 91891004420 FAD binding motif [chemical binding]; other site 91891004421 phosphate binding motif [ion binding]; other site 91891004422 beta-alpha-beta structure motif; other site 91891004423 NAD binding pocket [chemical binding]; other site 91891004424 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 91891004425 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 91891004426 catalytic loop [active] 91891004427 iron binding site [ion binding]; other site 91891004428 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 91891004429 heme-binding residues [chemical binding]; other site 91891004430 Phospholipid methyltransferase; Region: PEMT; cl17370 91891004431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 91891004432 dimer interface [polypeptide binding]; other site 91891004433 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 91891004434 putative CheW interface [polypeptide binding]; other site 91891004435 putative transposase OrfB; Reviewed; Region: PHA02517 91891004436 Integrase core domain; Region: rve; pfam00665 91891004437 Integrase core domain; Region: rve_3; pfam13683 91891004438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891004439 Response regulator receiver domain; Region: Response_reg; pfam00072 91891004440 active site 91891004441 phosphorylation site [posttranslational modification] 91891004442 intermolecular recognition site; other site 91891004443 dimerization interface [polypeptide binding]; other site 91891004444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 91891004445 Heavy-metal-associated domain; Region: HMA; pfam00403 91891004446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891004447 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 91891004448 Double zinc ribbon; Region: DZR; pfam12773 91891004449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 91891004450 dimerization interface [polypeptide binding]; other site 91891004451 putative DNA binding site [nucleotide binding]; other site 91891004452 putative Zn2+ binding site [ion binding]; other site 91891004453 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 91891004454 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 91891004455 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 91891004456 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891004457 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 91891004458 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 91891004459 Multicopper oxidase; Region: Cu-oxidase; pfam00394 91891004460 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 91891004461 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 91891004462 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 91891004463 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 91891004464 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 91891004465 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 91891004466 Protein export membrane protein; Region: SecD_SecF; cl14618 91891004467 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 91891004468 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 91891004469 carboxyltransferase (CT) interaction site; other site 91891004470 biotinylation site [posttranslational modification]; other site 91891004471 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891004472 Outer membrane efflux protein; Region: OEP; pfam02321 91891004473 Outer membrane efflux protein; Region: OEP; pfam02321 91891004474 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 91891004475 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891004476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891004477 metal binding site [ion binding]; metal-binding site 91891004478 active site 91891004479 I-site; other site 91891004480 Evidence 7 : Gene remnant; Product type e : enzyme 91891004481 C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; Region: W2; cl17013 91891004482 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 91891004483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891004484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891004485 motif II; other site 91891004486 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 91891004487 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 91891004488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891004489 active site 91891004490 thymidine phosphorylase; Provisional; Region: PRK04350 91891004491 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 91891004492 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 91891004493 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 91891004494 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 91891004495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 91891004496 Beta-Casp domain; Region: Beta-Casp; smart01027 91891004497 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 91891004498 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 91891004499 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891004500 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891004501 Outer membrane efflux protein; Region: OEP; pfam02321 91891004502 Outer membrane efflux protein; Region: OEP; pfam02321 91891004503 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 91891004504 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 91891004505 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891004506 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 91891004507 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 91891004508 Soluble P-type ATPase [General function prediction only]; Region: COG4087 91891004509 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 91891004510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891004511 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 91891004512 non-specific DNA binding site [nucleotide binding]; other site 91891004513 salt bridge; other site 91891004514 sequence-specific DNA binding site [nucleotide binding]; other site 91891004515 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 91891004516 Catalytic site [active] 91891004517 Global regulator protein family; Region: CsrA; pfam02599 91891004518 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 91891004519 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 91891004520 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 91891004521 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 91891004522 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 91891004523 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 91891004524 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 91891004525 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 91891004526 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 91891004527 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 91891004528 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 91891004529 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 91891004530 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 91891004531 Domain of unknown function DUF87; Region: DUF87; pfam01935 91891004532 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 91891004533 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 91891004534 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 91891004535 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 91891004536 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 91891004537 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 91891004538 Integrase; Region: Integrase_1; pfam12835 91891004539 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 91891004540 Antirestriction protein (ArdA); Region: ArdA; pfam07275 91891004541 Helix-turn-helix domain; Region: HTH_17; pfam12728 91891004542 integrase; Provisional; Region: int; PHA02601 91891004543 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 91891004544 active site 91891004545 DNA binding site [nucleotide binding] 91891004546 Int/Topo IB signature motif; other site 91891004547 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 91891004548 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 91891004549 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891004550 Leucine-rich repeats; other site 91891004551 Substrate binding site [chemical binding]; other site 91891004552 RES domain; Region: RES; smart00953 91891004553 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 91891004554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891004555 S-adenosylmethionine binding site [chemical binding]; other site 91891004556 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 91891004557 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 91891004558 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 91891004559 nudix motif; other site 91891004560 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 91891004561 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 91891004562 putative catalytic cysteine [active] 91891004563 gamma-glutamyl kinase; Provisional; Region: PRK05429 91891004564 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 91891004565 nucleotide binding site [chemical binding]; other site 91891004566 homotetrameric interface [polypeptide binding]; other site 91891004567 putative phosphate binding site [ion binding]; other site 91891004568 putative allosteric binding site; other site 91891004569 PUA domain; Region: PUA; pfam01472 91891004570 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 91891004571 DNA binding residues [nucleotide binding] 91891004572 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 91891004573 dimer interface [polypeptide binding]; other site 91891004574 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 91891004575 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 91891004576 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 91891004577 DNA binding residues [nucleotide binding] 91891004578 dimer interface [polypeptide binding]; other site 91891004579 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 91891004580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891004581 Coenzyme A binding pocket [chemical binding]; other site 91891004582 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 91891004583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891004584 Coenzyme A binding pocket [chemical binding]; other site 91891004585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 91891004586 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 91891004587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891004588 Walker A/P-loop; other site 91891004589 ATP binding site [chemical binding]; other site 91891004590 Q-loop/lid; other site 91891004591 ABC transporter signature motif; other site 91891004592 Walker B; other site 91891004593 D-loop; other site 91891004594 H-loop/switch region; other site 91891004595 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 91891004596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891004597 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 91891004598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891004599 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 91891004600 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 91891004601 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 91891004602 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 91891004603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 91891004604 Penicillinase repressor; Region: Pencillinase_R; pfam03965 91891004605 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 91891004606 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 91891004607 Permutation of conserved domain; other site 91891004608 active site 91891004609 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 91891004610 putative hydrolase; Provisional; Region: PRK10985 91891004611 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 91891004612 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891004613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891004614 motif II; other site 91891004615 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 91891004616 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 91891004617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 91891004618 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 91891004619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891004620 NAD(P) binding site [chemical binding]; other site 91891004621 active site 91891004622 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 91891004623 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 91891004624 dimer interface [polypeptide binding]; other site 91891004625 active site 91891004626 CoA binding pocket [chemical binding]; other site 91891004627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 91891004628 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 91891004629 putative ADP-binding pocket [chemical binding]; other site 91891004630 PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360 91891004631 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 91891004632 FAD binding domain; Region: FAD_binding_4; pfam01565 91891004633 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 91891004634 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891004635 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 91891004636 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 91891004637 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 91891004638 active site 91891004639 catalytic site [active] 91891004640 tetramer interface [polypeptide binding]; other site 91891004641 enterobactin exporter EntS; Provisional; Region: PRK10489 91891004642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004643 putative substrate translocation pore; other site 91891004644 Predicted membrane protein [Function unknown]; Region: COG2119 91891004645 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 91891004646 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 91891004647 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 91891004648 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 91891004649 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 91891004650 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 91891004651 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 91891004652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891004653 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 91891004654 threonine synthase; Validated; Region: PRK09225 91891004655 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891004656 catalytic residue [active] 91891004657 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 91891004658 YceI-like domain; Region: YceI; pfam04264 91891004659 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 91891004660 YceI-like domain; Region: YceI; smart00867 91891004661 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 91891004662 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 91891004663 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 91891004664 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 91891004665 PYR/PP interface [polypeptide binding]; other site 91891004666 dimer interface [polypeptide binding]; other site 91891004667 TPP binding site [chemical binding]; other site 91891004668 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 91891004669 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 91891004670 TPP-binding site; other site 91891004671 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 91891004672 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 91891004673 substrate binding site [chemical binding]; other site 91891004674 ATP binding site [chemical binding]; other site 91891004675 KduI/IolB family; Region: KduI; pfam04962 91891004676 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 91891004677 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 91891004678 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 91891004679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004680 putative substrate translocation pore; other site 91891004681 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 91891004682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004683 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 91891004684 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 91891004685 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 91891004686 active site 91891004687 Zn binding site [ion binding]; other site 91891004688 ATP-grasp domain; Region: ATP-grasp_4; cl17255 91891004689 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 91891004690 Amidinotransferase; Region: Amidinotransf; cl12043 91891004691 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 91891004692 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891004693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 91891004694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891004695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891004696 putative substrate translocation pore; other site 91891004697 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 91891004698 Transglycosylase; Region: Transgly; pfam00912 91891004699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 91891004700 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 91891004701 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 91891004702 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 91891004703 MG2 domain; Region: A2M_N; pfam01835 91891004704 Alpha-2-macroglobulin family; Region: A2M; pfam00207 91891004705 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 91891004706 surface patch; other site 91891004707 thioester region; other site 91891004708 specificity defining residues; other site 91891004709 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891004710 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891004711 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891004712 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891004713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891004714 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 91891004715 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 91891004716 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 91891004717 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 91891004718 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 91891004719 active site 91891004720 catalytic site [active] 91891004721 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 91891004722 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 91891004723 active site 91891004724 substrate binding site [chemical binding]; other site 91891004725 cosubstrate binding site; other site 91891004726 catalytic site [active] 91891004727 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 91891004728 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 91891004729 ATP-grasp domain; Region: ATP-grasp_4; cl17255 91891004730 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 91891004731 amidophosphoribosyltransferase; Provisional; Region: PRK09246 91891004732 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 91891004733 active site 91891004734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891004735 active site 91891004736 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 91891004737 ATP binding site [chemical binding]; other site 91891004738 active site 91891004739 substrate binding site [chemical binding]; other site 91891004740 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 91891004741 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 91891004742 putative active site [active] 91891004743 catalytic triad [active] 91891004744 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 91891004745 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 91891004746 dimerization interface [polypeptide binding]; other site 91891004747 putative ATP binding site [chemical binding]; other site 91891004748 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 91891004749 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 91891004750 dimerization interface [polypeptide binding]; other site 91891004751 ATP binding site [chemical binding]; other site 91891004752 Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824 91891004753 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 91891004754 dimerization interface [polypeptide binding]; other site 91891004755 ATP binding site [chemical binding]; other site 91891004756 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 91891004757 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 91891004758 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 91891004759 DsbD alpha interface [polypeptide binding]; other site 91891004760 catalytic residues [active] 91891004761 short chain dehydrogenase; Provisional; Region: PRK05993 91891004762 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 91891004763 NADP binding site [chemical binding]; other site 91891004764 active site 91891004765 steroid binding site; other site 91891004766 D123; Region: D123; pfam07065 91891004767 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 91891004768 aconitate hydratase; Validated; Region: PRK09277 91891004769 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 91891004770 substrate binding site [chemical binding]; other site 91891004771 ligand binding site [chemical binding]; other site 91891004772 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 91891004773 substrate binding site [chemical binding]; other site 91891004774 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 91891004775 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 91891004776 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 91891004777 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 91891004778 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 91891004779 putative NAD(P) binding site [chemical binding]; other site 91891004780 active site 91891004781 putative substrate binding site [chemical binding]; other site 91891004782 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 91891004783 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 91891004784 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 91891004785 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 91891004786 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 91891004787 Proline dehydrogenase; Region: Pro_dh; pfam01619 91891004788 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 91891004789 Glutamate binding site [chemical binding]; other site 91891004790 NAD binding site [chemical binding]; other site 91891004791 catalytic residues [active] 91891004792 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 91891004793 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 91891004794 ProQ/FINO family; Region: ProQ; pfam04352 91891004795 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 91891004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891004797 S-adenosylmethionine binding site [chemical binding]; other site 91891004798 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 91891004799 ligand binding site [chemical binding]; other site 91891004800 active site 91891004801 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 91891004802 cell division protein MukB; Provisional; Region: mukB; PRK04863 91891004803 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 91891004804 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 91891004805 active site 91891004806 DNA binding site [nucleotide binding] 91891004807 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 91891004808 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 91891004809 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 91891004810 Catalytic site [active] 91891004811 hypothetical protein; Provisional; Region: PRK07338 91891004812 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 91891004813 metal binding site [ion binding]; metal-binding site 91891004814 dimer interface [polypeptide binding]; other site 91891004815 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 91891004816 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 91891004817 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 91891004818 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 91891004819 NAD(P) binding site [chemical binding]; other site 91891004820 catalytic residues [active] 91891004821 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891004822 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891004823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891004824 Cytochrome c; Region: Cytochrom_C; cl11414 91891004825 ribosome recycling factor; Reviewed; Region: frr; PRK00083 91891004826 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 91891004827 hinge region; other site 91891004828 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 91891004829 putative nucleotide binding site [chemical binding]; other site 91891004830 uridine monophosphate binding site [chemical binding]; other site 91891004831 homohexameric interface [polypeptide binding]; other site 91891004832 elongation factor Ts; Provisional; Region: tsf; PRK09377 91891004833 UBA/TS-N domain; Region: UBA; pfam00627 91891004834 Elongation factor TS; Region: EF_TS; pfam00889 91891004835 Elongation factor TS; Region: EF_TS; pfam00889 91891004836 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 91891004837 rRNA interaction site [nucleotide binding]; other site 91891004838 S8 interaction site; other site 91891004839 putative laminin-1 binding site; other site 91891004840 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 91891004841 dimer interface [polypeptide binding]; other site 91891004842 SET domain; Region: SET; pfam00856 91891004843 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891004844 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891004845 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 91891004846 active site 91891004847 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 91891004848 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 91891004849 metal binding triad; other site 91891004850 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 91891004851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 91891004852 Zn2+ binding site [ion binding]; other site 91891004853 Mg2+ binding site [ion binding]; other site 91891004854 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 91891004855 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 91891004856 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 91891004857 nucleoside/Zn binding site; other site 91891004858 dimer interface [polypeptide binding]; other site 91891004859 catalytic motif [active] 91891004860 GMP synthase; Reviewed; Region: guaA; PRK00074 91891004861 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 91891004862 AMP/PPi binding site [chemical binding]; other site 91891004863 candidate oxyanion hole; other site 91891004864 catalytic triad [active] 91891004865 potential glutamine specificity residues [chemical binding]; other site 91891004866 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 91891004867 ATP Binding subdomain [chemical binding]; other site 91891004868 Ligand Binding sites [chemical binding]; other site 91891004869 Dimerization subdomain; other site 91891004870 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 91891004871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 91891004872 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 91891004873 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 91891004874 active site 91891004875 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 91891004876 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 91891004877 Switch I; other site 91891004878 Switch II; other site 91891004879 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 91891004880 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 91891004881 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 91891004882 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 91891004883 active site 91891004884 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 91891004885 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891004886 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 91891004887 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 91891004888 Walker A/P-loop; other site 91891004889 ATP binding site [chemical binding]; other site 91891004890 Q-loop/lid; other site 91891004891 ABC transporter signature motif; other site 91891004892 Walker B; other site 91891004893 D-loop; other site 91891004894 H-loop/switch region; other site 91891004895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 91891004896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891004897 dimer interface [polypeptide binding]; other site 91891004898 conserved gate region; other site 91891004899 putative PBP binding loops; other site 91891004900 ABC-ATPase subunit interface; other site 91891004901 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 91891004902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891004903 dimer interface [polypeptide binding]; other site 91891004904 conserved gate region; other site 91891004905 putative PBP binding loops; other site 91891004906 ABC-ATPase subunit interface; other site 91891004907 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 91891004908 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 91891004909 NAD(P) binding site [chemical binding]; other site 91891004910 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 91891004911 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 91891004912 Cl- selectivity filter; other site 91891004913 Cl- binding residues [ion binding]; other site 91891004914 pore gating glutamate residue; other site 91891004915 dimer interface [polypeptide binding]; other site 91891004916 H+/Cl- coupling transport residue; other site 91891004917 anthranilate synthase; Provisional; Region: PRK13566 91891004918 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 91891004919 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 91891004920 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 91891004921 glutamine binding [chemical binding]; other site 91891004922 catalytic triad [active] 91891004923 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 91891004924 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 91891004925 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 91891004926 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 91891004927 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 91891004928 GatB domain; Region: GatB_Yqey; smart00845 91891004929 Autotransporter beta-domain; Region: Autotransporter; smart00869 91891004930 CHASE2 domain; Region: CHASE2; pfam05226 91891004931 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 91891004932 cyclase homology domain; Region: CHD; cd07302 91891004933 nucleotidyl binding site; other site 91891004934 metal binding site [ion binding]; metal-binding site 91891004935 dimer interface [polypeptide binding]; other site 91891004936 FecR protein; Region: FecR; pfam04773 91891004937 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 91891004938 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 91891004939 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 91891004940 trimerization site [polypeptide binding]; other site 91891004941 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 91891004942 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 91891004943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891004944 catalytic residue [active] 91891004945 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 91891004946 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 91891004947 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 91891004948 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 91891004949 active site 91891004950 dimerization interface [polypeptide binding]; other site 91891004951 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 91891004952 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 91891004953 tandem repeat interface [polypeptide binding]; other site 91891004954 oligomer interface [polypeptide binding]; other site 91891004955 active site residues [active] 91891004956 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 91891004957 Clp amino terminal domain; Region: Clp_N; pfam02861 91891004958 Clp amino terminal domain; Region: Clp_N; pfam02861 91891004959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891004960 Walker A motif; other site 91891004961 ATP binding site [chemical binding]; other site 91891004962 Walker B motif; other site 91891004963 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 91891004964 arginine finger; other site 91891004965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891004966 Walker A motif; other site 91891004967 ATP binding site [chemical binding]; other site 91891004968 Walker B motif; other site 91891004969 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 91891004970 Winged helix-turn helix; Region: HTH_29; pfam13551 91891004971 Helix-turn-helix domain; Region: HTH_28; pfam13518 91891004972 Integrase core domain; Region: rve; pfam00665 91891004973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 91891004974 Integrase core domain; Region: rve_3; pfam13683 91891004975 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 91891004976 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 91891004977 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 91891004978 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 91891004979 TIGR02099 family protein; Region: TIGR02099 91891004980 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 91891004981 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 91891004982 Flagellar FliJ protein; Region: FliJ; pfam02050 91891004983 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 91891004984 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 91891004985 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 91891004986 Walker A motif/ATP binding site; other site 91891004987 Walker B motif; other site 91891004988 Flagellar assembly protein FliH; Region: FliH; pfam02108 91891004989 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 91891004990 FliG C-terminal domain; Region: FliG_C; pfam01706 91891004991 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 91891004992 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 91891004993 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 91891004994 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 91891004995 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 91891004996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891004997 active site 91891004998 phosphorylation site [posttranslational modification] 91891004999 intermolecular recognition site; other site 91891005000 dimerization interface [polypeptide binding]; other site 91891005001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891005002 Walker A motif; other site 91891005003 ATP binding site [chemical binding]; other site 91891005004 Walker B motif; other site 91891005005 arginine finger; other site 91891005006 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 91891005007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 91891005008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891005009 putative active site [active] 91891005010 heme pocket [chemical binding]; other site 91891005011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891005012 dimer interface [polypeptide binding]; other site 91891005013 phosphorylation site [posttranslational modification] 91891005014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891005015 ATP binding site [chemical binding]; other site 91891005016 G-X-G motif; other site 91891005017 recombination factor protein RarA; Reviewed; Region: PRK13342 91891005018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891005019 Walker A motif; other site 91891005020 ATP binding site [chemical binding]; other site 91891005021 Walker B motif; other site 91891005022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 91891005023 arginine finger; other site 91891005024 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 91891005025 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 91891005026 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 91891005027 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 91891005028 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 91891005029 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 91891005030 thioredoxin reductase; Provisional; Region: PRK10262 91891005031 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 91891005032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 91891005033 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 91891005034 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 91891005035 active site residue [active] 91891005036 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 91891005037 rRNA binding site [nucleotide binding]; other site 91891005038 predicted 30S ribosome binding site; other site 91891005039 peptidase PmbA; Provisional; Region: PRK11040 91891005040 Predicted periplasmic protein [Function unknown]; Region: COG3698 91891005041 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 91891005042 Cupin-like domain; Region: Cupin_8; pfam13621 91891005043 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 91891005044 ATP cone domain; Region: ATP-cone; pfam03477 91891005045 ATP cone domain; Region: ATP-cone; pfam03477 91891005046 Class I ribonucleotide reductase; Region: RNR_I; cd01679 91891005047 active site 91891005048 dimer interface [polypeptide binding]; other site 91891005049 catalytic residues [active] 91891005050 effector binding site; other site 91891005051 R2 peptide binding site; other site 91891005052 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 91891005053 dimer interface [polypeptide binding]; other site 91891005054 putative radical transfer pathway; other site 91891005055 diiron center [ion binding]; other site 91891005056 tyrosyl radical; other site 91891005057 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 91891005058 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 91891005059 dimer interface [polypeptide binding]; other site 91891005060 putative anticodon binding site; other site 91891005061 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 91891005062 motif 1; other site 91891005063 active site 91891005064 motif 2; other site 91891005065 motif 3; other site 91891005066 peptide chain release factor 2; Validated; Region: prfB; PRK00578 91891005067 This domain is found in peptide chain release factors; Region: PCRF; smart00937 91891005068 RF-1 domain; Region: RF-1; pfam00472 91891005069 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 91891005070 flagellar motor protein MotD; Reviewed; Region: PRK09038 91891005071 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 91891005072 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 91891005073 ligand binding site [chemical binding]; other site 91891005074 flagellar motor protein; Reviewed; Region: motC; PRK09109 91891005075 flagellar motor protein MotA; Validated; Region: PRK08124 91891005076 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 91891005077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 91891005078 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 91891005079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 91891005080 DNA binding residues [nucleotide binding] 91891005081 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 91891005082 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 91891005083 P-loop; other site 91891005084 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 91891005085 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 91891005086 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 91891005087 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 91891005088 FHIPEP family; Region: FHIPEP; pfam00771 91891005089 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 91891005090 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 91891005091 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 91891005092 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 91891005093 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 91891005094 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 91891005095 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 91891005096 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 91891005097 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 91891005098 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 91891005099 FAD binding domain; Region: FAD_binding_4; pfam01565 91891005100 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 91891005101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891005102 NAD(P) binding site [chemical binding]; other site 91891005103 active site 91891005104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891005105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891005106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 91891005107 dimerization interface [polypeptide binding]; other site 91891005108 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 91891005109 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 91891005110 motif 1; other site 91891005111 active site 91891005112 motif 2; other site 91891005113 motif 3; other site 91891005114 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 91891005115 recombination regulator RecX; Reviewed; Region: recX; PRK00117 91891005116 recombinase A; Provisional; Region: recA; PRK09354 91891005117 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 91891005118 hexamer interface [polypeptide binding]; other site 91891005119 Walker A motif; other site 91891005120 ATP binding site [chemical binding]; other site 91891005121 Walker B motif; other site 91891005122 Competence-damaged protein; Region: CinA; pfam02464 91891005123 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 91891005124 MutS domain I; Region: MutS_I; pfam01624 91891005125 MutS domain II; Region: MutS_II; pfam05188 91891005126 MutS domain III; Region: MutS_III; pfam05192 91891005127 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 91891005128 Walker A/P-loop; other site 91891005129 ATP binding site [chemical binding]; other site 91891005130 Q-loop/lid; other site 91891005131 ABC transporter signature motif; other site 91891005132 Walker B; other site 91891005133 D-loop; other site 91891005134 H-loop/switch region; other site 91891005135 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 91891005136 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 91891005137 Surface antigen; Region: Bac_surface_Ag; pfam01103 91891005138 Family of unknown function (DUF490); Region: DUF490; pfam04357 91891005139 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 91891005140 dimer interface [polypeptide binding]; other site 91891005141 active site 91891005142 Schiff base residues; other site 91891005143 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 91891005144 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 91891005145 AAK_AK-DapDC: Amino Acid Kinase Superfamily (AAK), AK-DapDC; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the bifunctional enzyme AK - DAP decarboxylase (DapDC) found in some bacteria. Aspartokinase is the first enzyme in the...; Region: AAK_AK-DapDC; cd04259 91891005146 putative catalytic residues [active] 91891005147 putative nucleotide binding site [chemical binding]; other site 91891005148 putative aspartate binding site [chemical binding]; other site 91891005149 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC) bacterial protein; Region: ACT_AKiii-DAPDC_1; cd04935 91891005150 ACT domains of a bifunctional AKIII (LysC)-like aspartokinase/meso-diaminopimelate decarboxylase (DAPDC); Region: ACT_AKiii-DAPDC_2; cd04920 91891005151 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bifunctional Aspartate Kinase/Diaminopimelate Decarboxylase; Region: PLPDE_III_Bif_AspK_DapDC; cd06840 91891005152 active site 91891005153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 91891005154 substrate binding site [chemical binding]; other site 91891005155 catalytic residues [active] 91891005156 dimer interface [polypeptide binding]; other site 91891005157 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 91891005158 Part of AAA domain; Region: AAA_19; pfam13245 91891005159 Family description; Region: UvrD_C_2; pfam13538 91891005160 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 91891005161 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 91891005162 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 91891005163 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 91891005164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891005165 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 91891005166 dimerization interface [polypeptide binding]; other site 91891005167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891005168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891005169 putative substrate translocation pore; other site 91891005170 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 91891005171 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 91891005172 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 91891005173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 91891005174 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 91891005175 Walker A/P-loop; other site 91891005176 ATP binding site [chemical binding]; other site 91891005177 Q-loop/lid; other site 91891005178 ABC transporter signature motif; other site 91891005179 Walker B; other site 91891005180 D-loop; other site 91891005181 H-loop/switch region; other site 91891005182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891005183 Coenzyme A binding pocket [chemical binding]; other site 91891005184 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 91891005185 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 91891005186 quinone interaction residues [chemical binding]; other site 91891005187 active site 91891005188 catalytic residues [active] 91891005189 FMN binding site [chemical binding]; other site 91891005190 substrate binding site [chemical binding]; other site 91891005191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891005192 isovaleryl-CoA dehydrogenase; Region: PLN02519 91891005193 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 91891005194 substrate binding site [chemical binding]; other site 91891005195 FAD binding site [chemical binding]; other site 91891005196 catalytic base [active] 91891005197 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 91891005198 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 91891005199 dimer interface [polypeptide binding]; other site 91891005200 active site 91891005201 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 91891005202 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 91891005203 enoyl-CoA hydratase; Provisional; Region: PRK05995 91891005204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 91891005205 substrate binding site [chemical binding]; other site 91891005206 oxyanion hole (OAH) forming residues; other site 91891005207 trimer interface [polypeptide binding]; other site 91891005208 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 91891005209 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 91891005210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 91891005211 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 91891005212 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 91891005213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 91891005214 carboxyltransferase (CT) interaction site; other site 91891005215 biotinylation site [posttranslational modification]; other site 91891005216 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 91891005217 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 91891005218 active site 91891005219 catalytic residues [active] 91891005220 metal binding site [ion binding]; metal-binding site 91891005221 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 91891005222 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 91891005223 acyl-activating enzyme (AAE) consensus motif; other site 91891005224 putative AMP binding site [chemical binding]; other site 91891005225 putative active site [active] 91891005226 putative CoA binding site [chemical binding]; other site 91891005227 VirK protein; Region: VirK; pfam06903 91891005228 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 91891005229 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 91891005230 Walker A/P-loop; other site 91891005231 ATP binding site [chemical binding]; other site 91891005232 Q-loop/lid; other site 91891005233 ABC transporter signature motif; other site 91891005234 Walker B; other site 91891005235 D-loop; other site 91891005236 H-loop/switch region; other site 91891005237 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 91891005238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 91891005239 dimer interface [polypeptide binding]; other site 91891005240 conserved gate region; other site 91891005241 ABC-ATPase subunit interface; other site 91891005242 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 91891005243 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 91891005244 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 91891005245 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 91891005246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891005247 active site 91891005248 motif I; other site 91891005249 motif II; other site 91891005250 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 91891005251 DALR anticodon binding domain; Region: DALR_1; pfam05746 91891005252 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 91891005253 dimer interface [polypeptide binding]; other site 91891005254 motif 1; other site 91891005255 active site 91891005256 motif 2; other site 91891005257 motif 3; other site 91891005258 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 91891005259 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 91891005260 catalytic residues [active] 91891005261 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 91891005262 Part of AAA domain; Region: AAA_19; pfam13245 91891005263 Family description; Region: UvrD_C_2; pfam13538 91891005264 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 91891005265 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 91891005266 putative active site [active] 91891005267 dimerization interface [polypeptide binding]; other site 91891005268 putative tRNAtyr binding site [nucleotide binding]; other site 91891005269 VacJ like lipoprotein; Region: VacJ; cl01073 91891005270 glutathione synthetase; Provisional; Region: PRK05246 91891005271 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 91891005272 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 91891005273 Glutamate-cysteine ligase; Region: GshA; pfam08886 91891005274 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 91891005275 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 91891005276 EamA-like transporter family; Region: EamA; pfam00892 91891005277 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 91891005278 active site residue [active] 91891005279 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 91891005280 PglZ domain; Region: PglZ; pfam08665 91891005281 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 91891005282 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 91891005283 Sugar specificity; other site 91891005284 Pyrimidine base specificity; other site 91891005285 ATP-binding site [chemical binding]; other site 91891005286 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 91891005287 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 91891005288 NAD binding site [chemical binding]; other site 91891005289 homotetramer interface [polypeptide binding]; other site 91891005290 homodimer interface [polypeptide binding]; other site 91891005291 substrate binding site [chemical binding]; other site 91891005292 active site 91891005293 periplasmic folding chaperone; Provisional; Region: PRK10788 91891005294 SurA N-terminal domain; Region: SurA_N_3; cl07813 91891005295 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 91891005296 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 91891005297 IHF dimer interface [polypeptide binding]; other site 91891005298 IHF - DNA interface [nucleotide binding]; other site 91891005299 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 91891005300 Found in ATP-dependent protease La (LON); Region: LON; smart00464 91891005301 Found in ATP-dependent protease La (LON); Region: LON; smart00464 91891005302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891005303 Walker A motif; other site 91891005304 ATP binding site [chemical binding]; other site 91891005305 Walker B motif; other site 91891005306 arginine finger; other site 91891005307 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 91891005308 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 91891005309 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 91891005310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891005311 Walker A motif; other site 91891005312 ATP binding site [chemical binding]; other site 91891005313 Walker B motif; other site 91891005314 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 91891005315 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 91891005316 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 91891005317 oligomer interface [polypeptide binding]; other site 91891005318 active site residues [active] 91891005319 trigger factor; Provisional; Region: tig; PRK01490 91891005320 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 91891005321 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 91891005322 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 91891005323 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 91891005324 Int/Topo IB signature motif; other site 91891005325 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 91891005326 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891005327 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891005328 ABC transporter; Region: ABC_tran_2; pfam12848 91891005329 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891005330 ribonuclease III; Reviewed; Region: rnc; PRK00102 91891005331 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 91891005332 dimerization interface [polypeptide binding]; other site 91891005333 active site 91891005334 metal binding site [ion binding]; metal-binding site 91891005335 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 91891005336 dsRNA binding site [nucleotide binding]; other site 91891005337 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 91891005338 signal peptidase I; Provisional; Region: PRK10861 91891005339 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 91891005340 Catalytic site [active] 91891005341 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 91891005342 GTP-binding protein LepA; Provisional; Region: PRK05433 91891005343 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 91891005344 G1 box; other site 91891005345 putative GEF interaction site [polypeptide binding]; other site 91891005346 GTP/Mg2+ binding site [chemical binding]; other site 91891005347 Switch I region; other site 91891005348 G2 box; other site 91891005349 G3 box; other site 91891005350 Switch II region; other site 91891005351 G4 box; other site 91891005352 G5 box; other site 91891005353 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 91891005354 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 91891005355 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 91891005356 Transglycosylase SLT domain; Region: SLT_2; pfam13406 91891005357 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 91891005358 N-acetyl-D-glucosamine binding site [chemical binding]; other site 91891005359 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 91891005360 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 91891005361 GspL periplasmic domain; Region: GspL_C; cl14909 91891005362 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 91891005363 Sporulation related domain; Region: SPOR; cl10051 91891005364 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 91891005365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 91891005366 Zn2+ binding site [ion binding]; other site 91891005367 Mg2+ binding site [ion binding]; other site 91891005368 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 91891005369 DNA repair protein RecN; Region: recN; TIGR00634 91891005370 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 91891005371 Trehalase; Region: Trehalase; cl17346 91891005372 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 91891005373 dimer interface [polypeptide binding]; other site 91891005374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 91891005375 active site 91891005376 metal binding site [ion binding]; metal-binding site 91891005377 glutathione binding site [chemical binding]; other site 91891005378 hypothetical protein; Provisional; Region: PRK05208 91891005379 JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744 91891005380 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 91891005381 acylphosphatase; Provisional; Region: PRK14451 91891005382 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 91891005383 putative active site [active] 91891005384 catalytic site [active] 91891005385 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 91891005386 PLD-like domain; Region: PLDc_2; pfam13091 91891005387 putative active site [active] 91891005388 catalytic site [active] 91891005389 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 91891005390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 91891005391 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891005392 Leucine-rich repeats; other site 91891005393 Substrate binding site [chemical binding]; other site 91891005394 Leucine rich repeat; Region: LRR_8; pfam13855 91891005395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891005396 D-galactonate transporter; Region: 2A0114; TIGR00893 91891005397 putative substrate translocation pore; other site 91891005398 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 91891005399 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 91891005400 putative ion selectivity filter; other site 91891005401 putative pore gating glutamate residue; other site 91891005402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 91891005403 SEC-C motif; Region: SEC-C; pfam02810 91891005404 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 91891005405 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 91891005406 TrkA-N domain; Region: TrkA_N; pfam02254 91891005407 Uncharacterized conserved protein [Function unknown]; Region: COG2850 91891005408 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891005409 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 91891005410 EamA-like transporter family; Region: EamA; pfam00892 91891005411 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 91891005412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 91891005413 nucleotide binding site [chemical binding]; other site 91891005414 Protein of unknown function, DUF462; Region: DUF462; pfam04315 91891005415 glutathionine S-transferase; Provisional; Region: PRK10542 91891005416 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 91891005417 C-terminal domain interface [polypeptide binding]; other site 91891005418 GSH binding site (G-site) [chemical binding]; other site 91891005419 dimer interface [polypeptide binding]; other site 91891005420 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 91891005421 N-terminal domain interface [polypeptide binding]; other site 91891005422 dimer interface [polypeptide binding]; other site 91891005423 substrate binding pocket (H-site) [chemical binding]; other site 91891005424 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 91891005425 Beta-lactamase; Region: Beta-lactamase; pfam00144 91891005426 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 91891005427 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 91891005428 HIGH motif; other site 91891005429 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 91891005430 active site 91891005431 KMSKS motif; other site 91891005432 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 91891005433 HAMP domain; Region: HAMP; pfam00672 91891005434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891005435 dimer interface [polypeptide binding]; other site 91891005436 phosphorylation site [posttranslational modification] 91891005437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891005438 ATP binding site [chemical binding]; other site 91891005439 Mg2+ binding site [ion binding]; other site 91891005440 G-X-G motif; other site 91891005441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891005442 active site 91891005443 phosphorylation site [posttranslational modification] 91891005444 intermolecular recognition site; other site 91891005445 dimerization interface [polypeptide binding]; other site 91891005446 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 91891005447 putative binding surface; other site 91891005448 active site 91891005449 6-phosphofructokinase; Provisional; Region: PRK14072 91891005450 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 91891005451 active site 91891005452 ADP/pyrophosphate binding site [chemical binding]; other site 91891005453 dimerization interface [polypeptide binding]; other site 91891005454 allosteric effector site; other site 91891005455 fructose-1,6-bisphosphate binding site; other site 91891005456 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 91891005457 Pilin (bacterial filament); Region: Pilin; pfam00114 91891005458 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 91891005459 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 91891005460 Pilin (bacterial filament); Region: Pilin; pfam00114 91891005461 BolA-like protein; Region: BolA; cl00386 91891005462 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 91891005463 Calcium-activated chloride channel; Region: Anoctamin; pfam04547 91891005464 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 91891005465 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 91891005466 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 91891005467 Ligand binding site; other site 91891005468 oligomer interface; other site 91891005469 Uncharacterized conserved protein [Function unknown]; Region: COG2835 91891005470 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 91891005471 Glycoprotease family; Region: Peptidase_M22; pfam00814 91891005472 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 91891005473 DEAD/DEAH box helicase; Region: DEAD; pfam00270 91891005474 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 91891005475 Ferredoxin [Energy production and conversion]; Region: COG1146 91891005476 4Fe-4S binding domain; Region: Fer4; cl02805 91891005477 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 91891005478 HipA-like N-terminal domain; Region: HipA_N; pfam07805 91891005479 PilZ domain; Region: PilZ; pfam07238 91891005480 oxidative damage protection protein; Provisional; Region: PRK05408 91891005481 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 91891005482 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 91891005483 Integrase; Region: Integrase_1; pfam12835 91891005484 Domain of unknown function (DUF927); Region: DUF927; pfam06048 91891005485 Helix-turn-helix domain; Region: HTH_17; pfam12728 91891005486 LabA_like proteins; Region: LabA_like; cd06167 91891005487 putative metal binding site [ion binding]; other site 91891005488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 91891005489 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 91891005490 active site 91891005491 DNA binding site [nucleotide binding] 91891005492 Int/Topo IB signature motif; other site 91891005493 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 91891005494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 91891005495 Transposase; Region: DDE_Tnp_ISL3; pfam01610 91891005496 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 91891005497 Integrase; Region: Integrase_1; pfam12835 91891005498 AAA domain; Region: AAA_14; pfam13173 91891005499 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 91891005500 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 91891005501 Methyltransferase domain; Region: Methyltransf_31; pfam13847 91891005502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891005503 S-adenosylmethionine binding site [chemical binding]; other site 91891005504 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 91891005505 Transposase; Region: DEDD_Tnp_IS110; pfam01548 91891005506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 91891005507 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 91891005508 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 91891005509 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 91891005510 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 91891005511 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 91891005512 active site 91891005513 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 91891005514 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 91891005515 acyl-activating enzyme (AAE) consensus motif; other site 91891005516 AMP binding site [chemical binding]; other site 91891005517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 91891005518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 91891005519 active site 91891005520 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 91891005521 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 91891005522 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 91891005523 Phosphopantetheine attachment site; Region: PP-binding; cl09936 91891005524 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 91891005525 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 91891005526 active site 91891005527 nucleophile elbow; other site 91891005528 Patatin phospholipase; Region: DUF3734; pfam12536 91891005529 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 91891005530 PAS fold; Region: PAS_4; pfam08448 91891005531 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 91891005532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 91891005533 DNA binding residues [nucleotide binding] 91891005534 dimerization interface [polypeptide binding]; other site 91891005535 Evidence 7 : Gene remnant 91891005536 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891005537 Leucine-rich repeats; other site 91891005538 Substrate binding site [chemical binding]; other site 91891005539 Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; Region: Sec7; cd00171 91891005540 active site/putative ARF binding site [active] 91891005541 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 91891005542 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 91891005543 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 91891005544 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 91891005545 active site 91891005546 metal binding site [ion binding]; metal-binding site 91891005547 DctM-like transporters; Region: DctM; pfam06808 91891005548 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 91891005549 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 91891005550 active site 91891005551 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891005552 Leucine-rich repeats; other site 91891005553 Substrate binding site [chemical binding]; other site 91891005554 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891005555 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 91891005556 RasGEF domain; Region: RasGEF; pfam00617 91891005557 Ras interaction site [polypeptide binding]; other site 91891005558 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 91891005559 putative active site [active] 91891005560 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 91891005561 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 91891005562 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 91891005563 active site 91891005564 chromosome segregation protein; Provisional; Region: PRK03918 91891005565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 91891005566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 91891005567 POT family; Region: PTR2; cl17359 91891005568 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 91891005569 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 91891005570 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 91891005571 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 91891005572 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891005573 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 91891005574 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891005575 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 91891005576 EPTP domain; Region: EPTP; pfam03736 91891005577 EPTP domain; Region: EPTP; pfam03736 91891005578 TPR repeat; Region: TPR_11; pfam13414 91891005579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891005580 binding surface 91891005581 TPR motif; other site 91891005582 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 91891005583 guanine deaminase; Provisional; Region: PRK09228 91891005584 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 91891005585 active site 91891005586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 91891005587 Toprim domain; Region: Toprim_3; pfam13362 91891005588 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 91891005589 catalytic core [active] 91891005590 RibD C-terminal domain; Region: RibD_C; cl17279 91891005591 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 91891005592 MAPEG family; Region: MAPEG; cl09190 91891005593 YhhN-like protein; Region: YhhN; pfam07947 91891005594 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 91891005595 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 91891005596 NodB motif; other site 91891005597 putative active site [active] 91891005598 putative catalytic site [active] 91891005599 putative Zn binding site [ion binding]; other site 91891005600 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 91891005601 MltA specific insert domain; Region: MltA; pfam03562 91891005602 3D domain; Region: 3D; pfam06725 91891005603 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 91891005604 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 91891005605 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 91891005606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 91891005607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891005608 homodimer interface [polypeptide binding]; other site 91891005609 catalytic residue [active] 91891005610 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 91891005611 aromatic arch; other site 91891005612 DCoH dimer interaction site [polypeptide binding]; other site 91891005613 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 91891005614 DCoH tetramer interaction site [polypeptide binding]; other site 91891005615 substrate binding site [chemical binding]; other site 91891005616 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 91891005617 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 91891005618 Protein export membrane protein; Region: SecD_SecF; pfam02355 91891005619 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 91891005620 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 91891005621 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 91891005622 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 91891005623 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 91891005624 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 91891005625 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 91891005626 ABC transporter ATPase component; Reviewed; Region: PRK11147 91891005627 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891005628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891005629 ABC transporter; Region: ABC_tran_2; pfam12848 91891005630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 91891005631 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 91891005632 catalytic motif [active] 91891005633 Catalytic residue [active] 91891005634 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 91891005635 homotrimer interaction site [polypeptide binding]; other site 91891005636 putative active site [active] 91891005637 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 91891005638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 91891005639 Zn2+ binding site [ion binding]; other site 91891005640 Mg2+ binding site [ion binding]; other site 91891005641 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 91891005642 synthetase active site [active] 91891005643 NTP binding site [chemical binding]; other site 91891005644 metal binding site [ion binding]; metal-binding site 91891005645 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 91891005646 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 91891005647 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 91891005648 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 91891005649 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 91891005650 catalytic site [active] 91891005651 G-X2-G-X-G-K; other site 91891005652 hypothetical protein; Provisional; Region: PRK11820 91891005653 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 91891005654 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 91891005655 ribonuclease PH; Reviewed; Region: rph; PRK00173 91891005656 Ribonuclease PH; Region: RNase_PH_bact; cd11362 91891005657 hexamer interface [polypeptide binding]; other site 91891005658 active site 91891005659 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 91891005660 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 91891005661 Walker A motif; other site 91891005662 ATP binding site [chemical binding]; other site 91891005663 Walker B motif; other site 91891005664 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 91891005665 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 91891005666 catalytic residue [active] 91891005667 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 91891005668 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 91891005669 YGGT family; Region: YGGT; pfam02325 91891005670 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 91891005671 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 91891005672 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 91891005673 active site 91891005674 catalytic residues [active] 91891005675 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 91891005676 Helix-turn-helix domain; Region: HTH_18; pfam12833 91891005677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 91891005678 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 91891005679 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 91891005680 homotetramer interface [polypeptide binding]; other site 91891005681 ligand binding site [chemical binding]; other site 91891005682 catalytic site [active] 91891005683 NAD binding site [chemical binding]; other site 91891005684 S-adenosylmethionine synthetase; Validated; Region: PRK05250 91891005685 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 91891005686 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 91891005687 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 91891005688 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 91891005689 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 91891005690 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 91891005691 catalytic site [active] 91891005692 subunit interface [polypeptide binding]; other site 91891005693 chaperone protein DnaJ; Provisional; Region: PRK10767 91891005694 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 91891005695 HSP70 interaction site [polypeptide binding]; other site 91891005696 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 91891005697 substrate binding site [polypeptide binding]; other site 91891005698 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 91891005699 Zn binding sites [ion binding]; other site 91891005700 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 91891005701 dimer interface [polypeptide binding]; other site 91891005702 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 91891005703 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 91891005704 nucleotide binding site [chemical binding]; other site 91891005705 GrpE; Region: GrpE; pfam01025 91891005706 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 91891005707 dimer interface [polypeptide binding]; other site 91891005708 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 91891005709 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 91891005710 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 91891005711 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 91891005712 substrate binding site [chemical binding]; other site 91891005713 active site 91891005714 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 91891005715 homooctamer interface [polypeptide binding]; other site 91891005716 active site 91891005717 Sporulation related domain; Region: SPOR; pfam05036 91891005718 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 91891005719 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 91891005720 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 91891005721 active site 91891005722 HIGH motif; other site 91891005723 nucleotide binding site [chemical binding]; other site 91891005724 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 91891005725 KMSK motif region; other site 91891005726 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 91891005727 tRNA binding surface [nucleotide binding]; other site 91891005728 anticodon binding site; other site 91891005729 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 91891005730 Domain of unknown function DUF20; Region: UPF0118; pfam01594 91891005731 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 91891005732 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 91891005733 generic binding surface II; other site 91891005734 ssDNA binding site; other site 91891005735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891005736 ATP binding site [chemical binding]; other site 91891005737 putative Mg++ binding site [ion binding]; other site 91891005738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891005739 nucleotide binding region [chemical binding]; other site 91891005740 ATP-binding site [chemical binding]; other site 91891005741 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 91891005742 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 91891005743 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 91891005744 ZIP Zinc transporter; Region: Zip; pfam02535 91891005745 Maf-like protein; Region: Maf; pfam02545 91891005746 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 91891005747 active site 91891005748 dimer interface [polypeptide binding]; other site 91891005749 enolase; Provisional; Region: eno; PRK00077 91891005750 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 91891005751 dimer interface [polypeptide binding]; other site 91891005752 metal binding site [ion binding]; metal-binding site 91891005753 substrate binding pocket [chemical binding]; other site 91891005754 Septum formation initiator; Region: DivIC; cl17659 91891005755 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 91891005756 mevalonate kinase; Region: mevalon_kin; TIGR00549 91891005757 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 91891005758 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 91891005759 diphosphomevalonate decarboxylase; Region: PLN02407 91891005760 diphosphomevalonate decarboxylase; Region: PLN02407 91891005761 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 91891005762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891005763 FeS/SAM binding site; other site 91891005764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891005765 binding surface 91891005766 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 91891005767 TPR motif; other site 91891005768 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 91891005769 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 91891005770 ligand binding site [chemical binding]; other site 91891005771 Protein of unknown function (DUF330); Region: DUF330; cl01135 91891005772 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 91891005773 mce related protein; Region: MCE; pfam02470 91891005774 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 91891005775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891005776 Walker A/P-loop; other site 91891005777 ATP binding site [chemical binding]; other site 91891005778 Q-loop/lid; other site 91891005779 ABC transporter signature motif; other site 91891005780 Walker B; other site 91891005781 D-loop; other site 91891005782 H-loop/switch region; other site 91891005783 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 91891005784 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 91891005785 Permease; Region: Permease; pfam02405 91891005786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 91891005787 active site 91891005788 ATP binding site [chemical binding]; other site 91891005789 substrate binding site [chemical binding]; other site 91891005790 activation loop (A-loop); other site 91891005791 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 91891005792 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 91891005793 homotetramer interface [polypeptide binding]; other site 91891005794 FMN binding site [chemical binding]; other site 91891005795 homodimer contacts [polypeptide binding]; other site 91891005796 putative active site [active] 91891005797 putative substrate binding site [chemical binding]; other site 91891005798 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 91891005799 homodimer interface [polypeptide binding]; other site 91891005800 catalytic residues [active] 91891005801 NAD binding site [chemical binding]; other site 91891005802 substrate binding pocket [chemical binding]; other site 91891005803 flexible flap; other site 91891005804 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 91891005805 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 91891005806 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891005807 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 91891005808 transposase/IS protein; Provisional; Region: PRK09183 91891005809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891005810 Walker A motif; other site 91891005811 ATP binding site [chemical binding]; other site 91891005812 Walker B motif; other site 91891005813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 91891005814 Helix-turn-helix domain; Region: HTH_38; pfam13936 91891005815 Integrase core domain; Region: rve; pfam00665 91891005816 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891005817 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891005818 DNA-binding site [nucleotide binding]; DNA binding site 91891005819 RNA-binding motif; other site 91891005820 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 91891005821 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 91891005822 ATP binding site [chemical binding]; other site 91891005823 Mg++ binding site [ion binding]; other site 91891005824 motif III; other site 91891005825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891005826 nucleotide binding region [chemical binding]; other site 91891005827 ATP-binding site [chemical binding]; other site 91891005828 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 91891005829 putative RNA binding site [nucleotide binding]; other site 91891005830 Cation efflux family; Region: Cation_efflux; cl00316 91891005831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 91891005832 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 91891005833 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 91891005834 ligand binding site [chemical binding]; other site 91891005835 K+ potassium transporter; Region: K_trans; pfam02705 91891005836 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891005837 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891005838 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891005839 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891005840 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 91891005841 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891005842 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891005843 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891005844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891005845 metabolite-proton symporter; Region: 2A0106; TIGR00883 91891005846 putative substrate translocation pore; other site 91891005847 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 91891005848 Protein export membrane protein; Region: SecD_SecF; cl14618 91891005849 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 91891005850 carboxyltransferase (CT) interaction site; other site 91891005851 biotinylation site [posttranslational modification]; other site 91891005852 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891005853 Outer membrane efflux protein; Region: OEP; pfam02321 91891005854 Outer membrane efflux protein; Region: OEP; pfam02321 91891005855 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 91891005856 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 91891005857 active site 91891005858 ATP binding site [chemical binding]; other site 91891005859 substrate binding site [chemical binding]; other site 91891005860 activation loop (A-loop); other site 91891005861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891005862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891005863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 91891005864 dimerization interface [polypeptide binding]; other site 91891005865 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 91891005866 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 91891005867 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 91891005868 Predicted transcriptional regulators [Transcription]; Region: COG1733 91891005869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 91891005870 classical (c) SDRs; Region: SDR_c; cd05233 91891005871 NAD(P) binding site [chemical binding]; other site 91891005872 active site 91891005873 F-box-like; Region: F-box-like; pfam12937 91891005874 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 91891005875 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891005876 Response regulator receiver domain; Region: Response_reg; pfam00072 91891005877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891005878 active site 91891005879 phosphorylation site [posttranslational modification] 91891005880 intermolecular recognition site; other site 91891005881 dimerization interface [polypeptide binding]; other site 91891005882 PAS domain; Region: PAS; smart00091 91891005883 PAS fold; Region: PAS_4; pfam08448 91891005884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 91891005885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891005886 dimer interface [polypeptide binding]; other site 91891005887 phosphorylation site [posttranslational modification] 91891005888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891005889 ATP binding site [chemical binding]; other site 91891005890 Mg2+ binding site [ion binding]; other site 91891005891 G-X-G motif; other site 91891005892 Response regulator receiver domain; Region: Response_reg; pfam00072 91891005893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891005894 active site 91891005895 phosphorylation site [posttranslational modification] 91891005896 intermolecular recognition site; other site 91891005897 dimerization interface [polypeptide binding]; other site 91891005898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891005899 dimer interface [polypeptide binding]; other site 91891005900 phosphorylation site [posttranslational modification] 91891005901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891005902 ATP binding site [chemical binding]; other site 91891005903 Mg2+ binding site [ion binding]; other site 91891005904 G-X-G motif; other site 91891005905 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 91891005906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 91891005907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 91891005908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891005909 Walker A/P-loop; other site 91891005910 ATP binding site [chemical binding]; other site 91891005911 Q-loop/lid; other site 91891005912 ABC transporter signature motif; other site 91891005913 Walker B; other site 91891005914 D-loop; other site 91891005915 H-loop/switch region; other site 91891005916 Dot/Icm substrate protein; Region: SidE; pfam12252 91891005917 Dot/Icm substrate protein; Region: SidE; pfam12252 91891005918 Evidence 2b : Function of strongly homologous gene; Product type f : factor 91891005919 Evidence 2b : Function of strongly homologous gene; Product type f : factor 91891005920 Dot/Icm substrate protein; Region: SidE; pfam12252 91891005921 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 91891005922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891005923 S-adenosylmethionine binding site [chemical binding]; other site 91891005924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891005925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891005926 S-adenosylmethionine binding site [chemical binding]; other site 91891005927 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 91891005928 Helix-turn-helix domain; Region: HTH_18; pfam12833 91891005929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 91891005930 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 91891005931 Predicted transcriptional regulator [Transcription]; Region: COG2378 91891005932 HTH domain; Region: HTH_11; pfam08279 91891005933 WYL domain; Region: WYL; pfam13280 91891005934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 91891005935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891005936 Coenzyme A binding pocket [chemical binding]; other site 91891005937 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 91891005938 putative dimer interface [polypeptide binding]; other site 91891005939 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 91891005940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891005941 Coenzyme A binding pocket [chemical binding]; other site 91891005942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891005943 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 91891005944 Coenzyme A binding pocket [chemical binding]; other site 91891005945 S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Region: SAM1; COG0499 91891005946 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 91891005947 NAD binding site [chemical binding]; other site 91891005948 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 91891005949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 91891005950 active site 91891005951 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 91891005952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891005953 catalytic residue [active] 91891005954 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891005955 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891005956 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891005957 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 91891005958 N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649 91891005959 putative active site [active] 91891005960 putative substrate binding site [chemical binding]; other site 91891005961 putative cosubstrate binding site; other site 91891005962 catalytic site [active] 91891005963 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 91891005964 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 91891005965 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 91891005966 acyl-activating enzyme (AAE) consensus motif; other site 91891005967 AMP binding site [chemical binding]; other site 91891005968 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 91891005969 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 91891005970 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 91891005971 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 91891005972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891005973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 91891005974 dimer interface [polypeptide binding]; other site 91891005975 phosphorylation site [posttranslational modification] 91891005976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891005977 ATP binding site [chemical binding]; other site 91891005978 Mg2+ binding site [ion binding]; other site 91891005979 G-X-G motif; other site 91891005980 Response regulator receiver domain; Region: Response_reg; pfam00072 91891005981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891005982 active site 91891005983 phosphorylation site [posttranslational modification] 91891005984 intermolecular recognition site; other site 91891005985 dimerization interface [polypeptide binding]; other site 91891005986 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 91891005987 putative binding surface; other site 91891005988 active site 91891005989 PAS fold; Region: PAS_4; pfam08448 91891005990 Response regulator receiver domain; Region: Response_reg; pfam00072 91891005991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891005992 active site 91891005993 phosphorylation site [posttranslational modification] 91891005994 intermolecular recognition site; other site 91891005995 dimerization interface [polypeptide binding]; other site 91891005996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891005997 Methyltransferase domain; Region: Methyltransf_31; pfam13847 91891005998 S-adenosylmethionine binding site [chemical binding]; other site 91891005999 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 91891006000 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 91891006001 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 91891006002 active site 91891006003 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 91891006004 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 91891006005 active site 91891006006 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 91891006007 KR domain; Region: KR; pfam08659 91891006008 NADP binding site [chemical binding]; other site 91891006009 active site 91891006010 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 91891006011 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 91891006012 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 91891006013 active site 91891006014 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 91891006015 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 91891006016 KR domain; Region: KR; pfam08659 91891006017 putative NADP binding site [chemical binding]; other site 91891006018 active site 91891006019 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 91891006020 Condensation domain; Region: Condensation; pfam00668 91891006021 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 91891006022 Peptidase C80 family; Region: Peptidase_C80; pfam11713 91891006023 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891006024 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891006025 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 91891006026 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 91891006027 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 91891006028 putative dimer interface [polypeptide binding]; other site 91891006029 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 91891006030 Sulfate transporter family; Region: Sulfate_transp; pfam00916 91891006031 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 91891006032 active site clefts [active] 91891006033 zinc binding site [ion binding]; other site 91891006034 dimer interface [polypeptide binding]; other site 91891006035 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 91891006036 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 91891006037 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 91891006038 SnoaL-like domain; Region: SnoaL_3; pfam13474 91891006039 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891006040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006041 S-adenosylmethionine binding site [chemical binding]; other site 91891006042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006043 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 91891006044 putative substrate translocation pore; other site 91891006045 POT family; Region: PTR2; cl17359 91891006046 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 91891006047 hypothetical protein; Reviewed; Region: PRK09588 91891006048 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 91891006049 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 91891006050 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 91891006051 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 91891006052 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 91891006053 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 91891006054 putative NAD(P) binding site [chemical binding]; other site 91891006055 dimer interface [polypeptide binding]; other site 91891006056 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 91891006057 substrate binding site [chemical binding]; other site 91891006058 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 91891006059 YARHG domain; Region: YARHG; pfam13308 91891006060 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 91891006061 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 91891006062 active site 91891006063 metal binding site [ion binding]; metal-binding site 91891006064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891006065 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 91891006066 NAD(P) binding site [chemical binding]; other site 91891006067 active site 91891006068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891006069 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891006070 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891006071 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 91891006072 iron-sulfur cluster [ion binding]; other site 91891006073 [2Fe-2S] cluster binding site [ion binding]; other site 91891006074 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 91891006075 hydrophobic ligand binding site; other site 91891006076 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 91891006077 putative trimer interface [polypeptide binding]; other site 91891006078 putative CoA binding site [chemical binding]; other site 91891006079 Sel1 repeat; Region: Sel1; pfam08238 91891006080 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891006081 Sel1-like repeats; Region: SEL1; smart00671 91891006082 Sel1 repeat; Region: Sel1; pfam08238 91891006083 Sel1-like repeats; Region: SEL1; smart00671 91891006084 Sel1-like repeats; Region: SEL1; smart00671 91891006085 Sel1-like repeats; Region: SEL1; smart00671 91891006086 Evidence 4 : Homologs of previously reported genes of unknown function 91891006087 Evidence 4 : Homologs of previously reported genes of unknown function 91891006088 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 91891006089 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 91891006090 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 91891006091 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 91891006092 GH3 auxin-responsive promoter; Region: GH3; pfam03321 91891006093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 91891006094 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 91891006095 active site 91891006096 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 91891006097 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 91891006098 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 91891006099 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 91891006100 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 91891006101 active site 91891006102 acyl-CoA synthetase; Validated; Region: PRK05850 91891006103 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 91891006104 acyl-activating enzyme (AAE) consensus motif; other site 91891006105 active site 91891006106 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 91891006107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 91891006108 acyl-activating enzyme (AAE) consensus motif; other site 91891006109 AMP binding site [chemical binding]; other site 91891006110 active site 91891006111 CoA binding site [chemical binding]; other site 91891006112 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 91891006113 classical (c) SDRs; Region: SDR_c; cd05233 91891006114 NAD(P) binding site [chemical binding]; other site 91891006115 active site 91891006116 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 91891006117 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 91891006118 dimer interface [polypeptide binding]; other site 91891006119 active site 91891006120 CoA binding pocket [chemical binding]; other site 91891006121 Phosphopantetheine attachment site; Region: PP-binding; cl09936 91891006122 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 91891006123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006124 putative substrate translocation pore; other site 91891006125 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 91891006126 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 91891006127 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 91891006128 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 91891006129 Binuclear center (active site) [active] 91891006130 K-pathway; other site 91891006131 Putative proton exit pathway; other site 91891006132 Putative water exit pathway; other site 91891006133 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 91891006134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 91891006135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891006136 Walker A/P-loop; other site 91891006137 ATP binding site [chemical binding]; other site 91891006138 Q-loop/lid; other site 91891006139 ABC transporter signature motif; other site 91891006140 Walker B; other site 91891006141 D-loop; other site 91891006142 H-loop/switch region; other site 91891006143 MAPEG family; Region: MAPEG; cl09190 91891006144 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 91891006145 active site 91891006146 nucleophile elbow; other site 91891006147 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891006148 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 91891006149 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891006150 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 91891006151 hypothetical protein; Validated; Region: PRK07198 91891006152 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 91891006153 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 91891006154 dimerization interface [polypeptide binding]; other site 91891006155 active site 91891006156 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 91891006157 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891006158 active site 91891006159 Evidence 4 : Homologs of previously reported genes of unknown function 91891006160 putative transposase OrfB; Reviewed; Region: PHA02517 91891006161 Integrase core domain; Region: rve; pfam00665 91891006162 Integrase core domain; Region: rve_3; pfam13683 91891006163 Evidence 4 : Homologs of previously reported genes of unknown function 91891006164 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 91891006165 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 91891006166 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 91891006167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 91891006168 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 91891006169 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 91891006170 catalytic triad [active] 91891006171 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 91891006172 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 91891006173 putative active site [active] 91891006174 metal binding site [ion binding]; metal-binding site 91891006175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 91891006176 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 91891006177 NAD(P) binding site [chemical binding]; other site 91891006178 catalytic residues [active] 91891006179 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 91891006180 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 91891006181 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 91891006182 hypothetical protein; Provisional; Region: PRK05409 91891006183 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 91891006184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 91891006185 Beta-Casp domain; Region: Beta-Casp; pfam10996 91891006186 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 91891006187 BON domain; Region: BON; pfam04972 91891006188 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 91891006189 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 91891006190 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 91891006191 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 91891006192 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 91891006193 dimer interaction site [polypeptide binding]; other site 91891006194 substrate-binding tunnel; other site 91891006195 active site 91891006196 catalytic site [active] 91891006197 substrate binding site [chemical binding]; other site 91891006198 phosphate acetyltransferase; Provisional; Region: PRK11890 91891006199 Acetokinase family; Region: Acetate_kinase; cl17229 91891006200 propionate/acetate kinase; Provisional; Region: PRK12379 91891006201 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 91891006202 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 91891006203 HSP70 interaction site [polypeptide binding]; other site 91891006204 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 91891006205 substrate binding site [polypeptide binding]; other site 91891006206 dimer interface [polypeptide binding]; other site 91891006207 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 91891006208 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 91891006209 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 91891006210 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 91891006211 putative acyl-acceptor binding pocket; other site 91891006212 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 91891006213 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 91891006214 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 91891006215 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 91891006216 active site 91891006217 probable DNA repair protein; Region: TIGR03623 91891006218 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 91891006219 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 91891006220 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 91891006221 putative NAD(P) binding site [chemical binding]; other site 91891006222 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 91891006223 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 91891006224 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 91891006225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 91891006226 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 91891006227 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 91891006228 putative active site [active] 91891006229 catalytic site [active] 91891006230 putative metal binding site [ion binding]; other site 91891006231 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 91891006232 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 91891006233 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 91891006234 NAD binding site [chemical binding]; other site 91891006235 Phe binding site; other site 91891006236 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 91891006237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006238 S-adenosylmethionine binding site [chemical binding]; other site 91891006239 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 91891006240 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 91891006241 dimer interface [polypeptide binding]; other site 91891006242 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 91891006243 active site 91891006244 Fe binding site [ion binding]; other site 91891006245 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 91891006246 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 91891006247 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 91891006248 maleylacetoacetate isomerase; Region: maiA; TIGR01262 91891006249 C-terminal domain interface [polypeptide binding]; other site 91891006250 GSH binding site (G-site) [chemical binding]; other site 91891006251 putative dimer interface [polypeptide binding]; other site 91891006252 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 91891006253 dimer interface [polypeptide binding]; other site 91891006254 N-terminal domain interface [polypeptide binding]; other site 91891006255 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 91891006256 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 91891006257 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 91891006258 putative dimer interface [polypeptide binding]; other site 91891006259 putative anticodon binding site; other site 91891006260 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 91891006261 homodimer interface [polypeptide binding]; other site 91891006262 motif 1; other site 91891006263 motif 2; other site 91891006264 active site 91891006265 motif 3; other site 91891006266 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 91891006267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 91891006268 Walker A/P-loop; other site 91891006269 ATP binding site [chemical binding]; other site 91891006270 Q-loop/lid; other site 91891006271 ABC transporter signature motif; other site 91891006272 Walker B; other site 91891006273 D-loop; other site 91891006274 H-loop/switch region; other site 91891006275 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 91891006276 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 91891006277 FtsX-like permease family; Region: FtsX; pfam02687 91891006278 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 91891006279 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 91891006280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891006281 motif II; other site 91891006282 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 91891006283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 91891006284 RNA binding surface [nucleotide binding]; other site 91891006285 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 91891006286 active site 91891006287 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 91891006288 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 91891006289 homodimer interface [polypeptide binding]; other site 91891006290 oligonucleotide binding site [chemical binding]; other site 91891006291 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 91891006292 ATP-dependent helicase HepA; Validated; Region: PRK04914 91891006293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891006294 ATP binding site [chemical binding]; other site 91891006295 putative Mg++ binding site [ion binding]; other site 91891006296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891006297 nucleotide binding region [chemical binding]; other site 91891006298 ATP-binding site [chemical binding]; other site 91891006299 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891006300 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 91891006301 Smr domain; Region: Smr; pfam01713 91891006302 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 91891006303 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 91891006304 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 91891006305 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 91891006306 Tetramer interface [polypeptide binding]; other site 91891006307 active site 91891006308 FMN-binding site [chemical binding]; other site 91891006309 HemK family putative methylases; Region: hemK_fam; TIGR00536 91891006310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006311 S-adenosylmethionine binding site [chemical binding]; other site 91891006312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 91891006313 Smr domain; Region: Smr; pfam01713 91891006314 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 91891006315 active site residue [active] 91891006316 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 91891006317 GSH binding site [chemical binding]; other site 91891006318 catalytic residues [active] 91891006319 preprotein translocase subunit SecB; Validated; Region: PRK05751 91891006320 SecA binding site; other site 91891006321 Preprotein binding site; other site 91891006322 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 91891006323 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 91891006324 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 91891006325 glutamate racemase; Provisional; Region: PRK00865 91891006326 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 91891006327 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 91891006328 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 91891006329 dihydrodipicolinate synthase; Region: dapA; TIGR00674 91891006330 dimer interface [polypeptide binding]; other site 91891006331 active site 91891006332 catalytic residue [active] 91891006333 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 91891006334 classical (c) SDRs; Region: SDR_c; cd05233 91891006335 NAD(P) binding site [chemical binding]; other site 91891006336 active site 91891006337 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 91891006338 nucleophile elbow; other site 91891006339 Patatin phospholipase; Region: DUF3734; pfam12536 91891006340 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 91891006341 flagellar motor protein MotA; Validated; Region: PRK09110 91891006342 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 91891006343 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 91891006344 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 91891006345 ligand binding site [chemical binding]; other site 91891006346 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 91891006347 serine transporter; Region: stp; TIGR00814 91891006348 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 91891006349 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891006350 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 91891006351 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891006352 ATP binding site [chemical binding]; other site 91891006353 Walker B motif; other site 91891006354 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 91891006355 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 91891006356 DNA repair protein RadA; Provisional; Region: PRK11823 91891006357 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891006358 Walker A motif; other site 91891006359 ATP binding site [chemical binding]; other site 91891006360 Walker B motif; other site 91891006361 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 91891006362 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 91891006363 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 91891006364 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 91891006365 substrate binding pocket [chemical binding]; other site 91891006366 chain length determination region; other site 91891006367 substrate-Mg2+ binding site; other site 91891006368 catalytic residues [active] 91891006369 aspartate-rich region 1; other site 91891006370 active site lid residues [active] 91891006371 aspartate-rich region 2; other site 91891006372 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 91891006373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006374 S-adenosylmethionine binding site [chemical binding]; other site 91891006375 comF family protein; Region: comF; TIGR00201 91891006376 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 91891006377 active site 91891006378 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 91891006379 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 91891006380 active site 91891006381 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 91891006382 protein binding site [polypeptide binding]; other site 91891006383 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 91891006384 putative substrate binding region [chemical binding]; other site 91891006385 GrpE; Region: GrpE; pfam01025 91891006386 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 91891006387 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 91891006388 tRNA; other site 91891006389 putative tRNA binding site [nucleotide binding]; other site 91891006390 putative NADP binding site [chemical binding]; other site 91891006391 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 91891006392 peptide chain release factor 1; Validated; Region: prfA; PRK00591 91891006393 This domain is found in peptide chain release factors; Region: PCRF; smart00937 91891006394 RF-1 domain; Region: RF-1; pfam00472 91891006395 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 91891006396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006397 S-adenosylmethionine binding site [chemical binding]; other site 91891006398 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 91891006399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 91891006400 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 91891006401 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 91891006402 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 91891006403 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 91891006404 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 91891006405 putative metal binding site [ion binding]; other site 91891006406 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 91891006407 HSP70 interaction site [polypeptide binding]; other site 91891006408 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 91891006409 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 91891006410 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 91891006411 active site 91891006412 catalytic triad [active] 91891006413 oxyanion hole [active] 91891006414 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 91891006415 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 91891006416 ATP binding site [chemical binding]; other site 91891006417 Mg++ binding site [ion binding]; other site 91891006418 motif III; other site 91891006419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 91891006420 nucleotide binding region [chemical binding]; other site 91891006421 ATP-binding site [chemical binding]; other site 91891006422 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 91891006423 putative RNA binding site [nucleotide binding]; other site 91891006424 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 91891006425 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 91891006426 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 91891006427 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 91891006428 active site 91891006429 FMN binding site [chemical binding]; other site 91891006430 2,4-decadienoyl-CoA binding site; other site 91891006431 catalytic residue [active] 91891006432 4Fe-4S cluster binding site [ion binding]; other site 91891006433 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 91891006434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 91891006435 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 91891006436 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 91891006437 E-class dimer interface [polypeptide binding]; other site 91891006438 P-class dimer interface [polypeptide binding]; other site 91891006439 active site 91891006440 Cu2+ binding site [ion binding]; other site 91891006441 Zn2+ binding site [ion binding]; other site 91891006442 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 91891006443 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 91891006444 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 91891006445 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 91891006446 dimer interface [polypeptide binding]; other site 91891006447 decamer (pentamer of dimers) interface [polypeptide binding]; other site 91891006448 catalytic triad [active] 91891006449 peroxidatic and resolving cysteines [active] 91891006450 malate dehydrogenase; Provisional; Region: PRK05442 91891006451 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 91891006452 NAD(P) binding site [chemical binding]; other site 91891006453 dimer interface [polypeptide binding]; other site 91891006454 malate binding site [chemical binding]; other site 91891006455 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 91891006456 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 91891006457 dimer interface [polypeptide binding]; other site 91891006458 ADP-ribose binding site [chemical binding]; other site 91891006459 active site 91891006460 nudix motif; other site 91891006461 metal binding site [ion binding]; metal-binding site 91891006462 HemN family oxidoreductase; Provisional; Region: PRK05660 91891006463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 91891006464 FeS/SAM binding site; other site 91891006465 HemN C-terminal domain; Region: HemN_C; pfam06969 91891006466 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 91891006467 Amidase; Region: Amidase; pfam01425 91891006468 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 91891006469 UGMP family protein; Validated; Region: PRK09604 91891006470 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 91891006471 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 91891006472 Yqey-like protein; Region: YqeY; pfam09424 91891006473 DNA primase; Validated; Region: dnaG; PRK05667 91891006474 CHC2 zinc finger; Region: zf-CHC2; pfam01807 91891006475 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 91891006476 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 91891006477 active site 91891006478 metal binding site [ion binding]; metal-binding site 91891006479 interdomain interaction site; other site 91891006480 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 91891006481 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 91891006482 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891006483 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891006484 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891006485 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891006486 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 91891006487 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 91891006488 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 91891006489 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 91891006490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 91891006491 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 91891006492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 91891006493 DNA binding residues [nucleotide binding] 91891006494 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 91891006495 active site 91891006496 NTP binding site [chemical binding]; other site 91891006497 metal binding triad [ion binding]; metal-binding site 91891006498 hypothetical protein; Provisional; Region: PRK01184 91891006499 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 91891006500 catalytic motif [active] 91891006501 Zn binding site [ion binding]; other site 91891006502 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process 91891006503 Evidence 2b : Function of strongly homologous gene; Product type cp : cell process 91891006504 Domain of unknown function (DUF927); Region: DUF927; pfam06048 91891006505 Helix-turn-helix domain; Region: HTH_17; pfam12728 91891006506 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 91891006507 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 91891006508 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891006509 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 91891006510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 91891006511 Transposase; Region: DDE_Tnp_ISL3; pfam01610 91891006512 Helix-turn-helix domain; Region: HTH_38; pfam13936 91891006513 Winged helix-turn helix; Region: HTH_29; pfam13551 91891006514 Homeodomain-like domain; Region: HTH_32; pfam13565 91891006515 Integrase core domain; Region: rve; pfam00665 91891006516 AAA domain; Region: AAA_14; pfam13173 91891006517 AAA domain; Region: AAA_22; pfam13401 91891006518 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 91891006519 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 91891006520 Protein of unknown function (DUF2433); Region: DUF2433; pfam10360 91891006521 Evidence 5 : No homology to any previously reported sequences 91891006522 Evidence 5 : No homology to any previously reported sequences 91891006523 Evidence 5 : No homology to any previously reported sequences 91891006524 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 91891006525 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin 91891006526 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin 91891006527 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 91891006528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891006529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891006530 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 91891006531 substrate binding pocket [chemical binding]; other site 91891006532 dimerization interface [polypeptide binding]; other site 91891006533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891006534 salt bridge; other site 91891006535 non-specific DNA binding site [nucleotide binding]; other site 91891006536 sequence-specific DNA binding site [nucleotide binding]; other site 91891006537 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator 91891006538 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type r : regulator 91891006539 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 91891006540 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 91891006541 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891006542 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 91891006543 Soluble P-type ATPase [General function prediction only]; Region: COG4087 91891006544 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 91891006545 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 91891006546 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 91891006547 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891006548 Soluble P-type ATPase [General function prediction only]; Region: COG4087 91891006549 Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in...; Region: t_SNARE; cd00193 91891006550 flanking leucine-zipper layers; other site 91891006551 zero layer; other site 91891006552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891006553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891006554 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 91891006555 putative effector binding pocket; other site 91891006556 dimerization interface [polypeptide binding]; other site 91891006557 Protein required for attachment to host cells; Region: Host_attach; pfam10116 91891006558 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 91891006559 putative FMN binding site [chemical binding]; other site 91891006560 NADPH bind site [chemical binding]; other site 91891006561 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 91891006562 potassium uptake protein; Region: kup; TIGR00794 91891006563 K+ potassium transporter; Region: K_trans; pfam02705 91891006564 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 91891006565 AAA domain; Region: AAA_18; pfam13238 91891006566 active site 91891006567 outer membrane protease; Reviewed; Region: PRK10993 91891006568 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 91891006569 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 91891006570 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 91891006571 dimer interface [polypeptide binding]; other site 91891006572 active site 91891006573 heme binding site [chemical binding]; other site 91891006574 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 91891006575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006576 metabolite-proton symporter; Region: 2A0106; TIGR00883 91891006577 putative substrate translocation pore; other site 91891006578 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 91891006579 Substrate binding site [chemical binding]; other site 91891006580 Ferritin-like domain; Region: Ferritin; pfam00210 91891006581 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 91891006582 dinuclear metal binding motif [ion binding]; other site 91891006583 Methyltransferase domain; Region: Methyltransf_31; pfam13847 91891006584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006585 S-adenosylmethionine binding site [chemical binding]; other site 91891006586 Peptidase family M23; Region: Peptidase_M23; pfam01551 91891006587 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 91891006588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 91891006589 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 91891006590 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 91891006591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 91891006592 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 91891006593 Beta-lactamase; Region: Beta-lactamase; pfam00144 91891006594 Transcriptional regulator [Transcription]; Region: LysR; COG0583 91891006595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 91891006596 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 91891006597 putative substrate binding pocket [chemical binding]; other site 91891006598 putative dimerization interface [polypeptide binding]; other site 91891006599 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 91891006600 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 91891006601 nudix motif; other site 91891006602 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 91891006603 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 91891006604 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 91891006605 GAF domain; Region: GAF; pfam01590 91891006606 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 91891006607 GAF domain; Region: GAF; cl17456 91891006608 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891006609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891006610 metal binding site [ion binding]; metal-binding site 91891006611 active site 91891006612 I-site; other site 91891006613 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 91891006614 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 91891006615 active site 91891006616 nucleophile elbow; other site 91891006617 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 91891006618 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 91891006619 Ras GTPase Activating Domain; Region: RasGAP; cl02569 91891006620 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 91891006621 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 91891006622 Beta-lactamase; Region: Beta-lactamase; pfam00144 91891006623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 91891006624 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 91891006625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891006626 Coenzyme A binding pocket [chemical binding]; other site 91891006627 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 91891006628 Coenzyme A transferase; Region: CoA_trans; cl17247 91891006629 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 91891006630 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 91891006631 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 91891006632 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 91891006633 malonate decarboxylase holo-[acyl-carrier-protein] synthase; Region: malonate_mdcG; TIGR03135 91891006634 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 91891006635 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 91891006636 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 91891006637 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891006638 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891006639 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891006640 Transposase; Region: DEDD_Tnp_IS110; pfam01548 91891006641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 91891006642 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 91891006643 Cupin domain; Region: Cupin_2; cl17218 91891006644 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 91891006645 Evidence 4 : Homologs of previously reported genes of unknown function 91891006646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006647 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 91891006648 putative substrate translocation pore; other site 91891006649 Predicted flavoprotein [General function prediction only]; Region: COG0431 91891006650 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 91891006651 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 91891006652 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 91891006653 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 91891006654 putative dimer interface [polypeptide binding]; other site 91891006655 N-terminal domain interface [polypeptide binding]; other site 91891006656 putative substrate binding pocket (H-site) [chemical binding]; other site 91891006657 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 91891006658 dimer interface [polypeptide binding]; other site 91891006659 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 91891006660 dimer interface [polypeptide binding]; other site 91891006661 Evidence 4 : Homologs of previously reported genes of unknown function 91891006662 Evidence 4 : Homologs of previously reported genes of unknown function 91891006663 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 91891006664 N-acetyltransferase; Region: Acetyltransf_2; cl00949 91891006665 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 91891006666 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 91891006667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 91891006668 Coenzyme A binding pocket [chemical binding]; other site 91891006669 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 91891006670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891006671 active site 91891006672 phosphorylation site [posttranslational modification] 91891006673 intermolecular recognition site; other site 91891006674 dimerization interface [polypeptide binding]; other site 91891006675 PAS domain S-box; Region: sensory_box; TIGR00229 91891006676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891006677 putative active site [active] 91891006678 heme pocket [chemical binding]; other site 91891006679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891006680 dimer interface [polypeptide binding]; other site 91891006681 phosphorylation site [posttranslational modification] 91891006682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891006683 ATP binding site [chemical binding]; other site 91891006684 Mg2+ binding site [ion binding]; other site 91891006685 G-X-G motif; other site 91891006686 Heme NO binding; Region: HNOB; pfam07700 91891006687 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 91891006688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006689 S-adenosylmethionine binding site [chemical binding]; other site 91891006690 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 91891006691 guanine nucleotide-exchange factor domain of Legionella SidM/DrrA; Region: SidM_DrrA_GEF; cd11689 91891006692 Rab1 interaction interface [polypeptide binding]; other site 91891006693 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 91891006694 nickel binding site [ion binding]; other site 91891006695 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 91891006696 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 91891006697 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 91891006698 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 91891006699 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 91891006700 FAD binding pocket [chemical binding]; other site 91891006701 FAD binding motif [chemical binding]; other site 91891006702 phosphate binding motif [ion binding]; other site 91891006703 beta-alpha-beta structure motif; other site 91891006704 NAD binding pocket [chemical binding]; other site 91891006705 Iron coordination center [ion binding]; other site 91891006706 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 91891006707 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 91891006708 dimerization interface [polypeptide binding]; other site 91891006709 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 91891006710 ATP binding site [chemical binding]; other site 91891006711 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 91891006712 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 91891006713 HupF/HypC family; Region: HupF_HypC; pfam01455 91891006714 Acylphosphatase; Region: Acylphosphatase; pfam00708 91891006715 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 91891006716 HypF finger; Region: zf-HYPF; pfam07503 91891006717 HypF finger; Region: zf-HYPF; pfam07503 91891006718 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 91891006719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 91891006720 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 91891006721 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 91891006722 High-affinity nickel-transport protein; Region: NicO; cl00964 91891006723 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 91891006724 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 91891006725 Ligand binding site; other site 91891006726 Putative Catalytic site; other site 91891006727 DXD motif; other site 91891006728 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 91891006729 putative active site [active] 91891006730 YdjC motif; other site 91891006731 Mg binding site [ion binding]; other site 91891006732 putative homodimer interface [polypeptide binding]; other site 91891006733 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 91891006734 EamA-like transporter family; Region: EamA; pfam00892 91891006735 EamA-like transporter family; Region: EamA; pfam00892 91891006736 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor 91891006737 Evidence 2b : Function of strongly homologous gene; Product type f : factor 91891006738 Uncharacterized conserved protein [Function unknown]; Region: COG2128 91891006739 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 91891006740 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 91891006741 active site 91891006742 dimerization interface [polypeptide binding]; other site 91891006743 TPR repeat; Region: TPR_11; pfam13414 91891006744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891006745 binding surface 91891006746 TPR motif; other site 91891006747 TPR repeat; Region: TPR_11; pfam13414 91891006748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891006749 binding surface 91891006750 TPR repeat; Region: TPR_11; pfam13414 91891006751 TPR motif; other site 91891006752 TPR repeat; Region: TPR_11; pfam13414 91891006753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891006754 binding surface 91891006755 TPR repeat; Region: TPR_11; pfam13414 91891006756 TPR motif; other site 91891006757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891006758 binding surface 91891006759 TPR motif; other site 91891006760 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 91891006761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 91891006762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006763 S-adenosylmethionine binding site [chemical binding]; other site 91891006764 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 91891006765 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 91891006766 active site 91891006767 substrate binding site [chemical binding]; other site 91891006768 metal binding site [ion binding]; metal-binding site 91891006769 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 91891006770 trimer interface [polypeptide binding]; other site 91891006771 active site 91891006772 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 91891006773 Flavoprotein; Region: Flavoprotein; pfam02441 91891006774 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 91891006775 hypothetical protein; Reviewed; Region: PRK00024 91891006776 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 91891006777 MPN+ (JAMM) motif; other site 91891006778 Zinc-binding site [ion binding]; other site 91891006779 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 91891006780 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 91891006781 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 91891006782 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 91891006783 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 91891006784 FOG: CBS domain [General function prediction only]; Region: COG0517 91891006785 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 91891006786 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 91891006787 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 91891006788 putative NAD(P) binding site [chemical binding]; other site 91891006789 putative substrate binding site [chemical binding]; other site 91891006790 catalytic Zn binding site [ion binding]; other site 91891006791 structural Zn binding site [ion binding]; other site 91891006792 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 91891006793 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 91891006794 putative dimer interface [polypeptide binding]; other site 91891006795 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 91891006796 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 91891006797 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 91891006798 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 91891006799 Thiamine pyrophosphokinase; Region: TPK; cd07995 91891006800 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 91891006801 active site 91891006802 dimerization interface [polypeptide binding]; other site 91891006803 thiamine binding site [chemical binding]; other site 91891006804 PQ loop repeat; Region: PQ-loop; pfam04193 91891006805 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 91891006806 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 91891006807 active site clefts [active] 91891006808 zinc binding site [ion binding]; other site 91891006809 dimer interface [polypeptide binding]; other site 91891006810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 91891006812 putative substrate translocation pore; other site 91891006813 Evidence 4 : Homologs of previously reported genes of unknown function 91891006814 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891006815 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891006816 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891006817 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891006818 Evidence 4 : Homologs of previously reported genes of unknown function 91891006819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 91891006820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 91891006821 dimer interface [polypeptide binding]; other site 91891006822 phosphorylation site [posttranslational modification] 91891006823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891006824 ATP binding site [chemical binding]; other site 91891006825 Mg2+ binding site [ion binding]; other site 91891006826 G-X-G motif; other site 91891006827 Dot/Icm substrate protein; Region: SidE; pfam12252 91891006828 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 91891006829 Protein export membrane protein; Region: SecD_SecF; cl14618 91891006830 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891006831 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891006832 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891006833 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 91891006834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 91891006835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006836 D-galactonate transporter; Region: 2A0114; TIGR00893 91891006837 putative substrate translocation pore; other site 91891006838 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 91891006839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 91891006840 putative DNA binding site [nucleotide binding]; other site 91891006841 putative Zn2+ binding site [ion binding]; other site 91891006842 AsnC family; Region: AsnC_trans_reg; pfam01037 91891006843 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 91891006844 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 91891006845 dimer interface [polypeptide binding]; other site 91891006846 active site 91891006847 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 91891006848 substrate binding site [chemical binding]; other site 91891006849 catalytic residue [active] 91891006850 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 91891006851 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 91891006852 active site 91891006853 catalytic site [active] 91891006854 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 91891006855 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 91891006856 Prephenate dehydratase; Region: PDT; pfam00800 91891006857 Chorismate mutase type II; Region: CM_2; smart00830 91891006858 aspartate aminotransferase; Provisional; Region: PRK05764 91891006859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 91891006860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891006861 homodimer interface [polypeptide binding]; other site 91891006862 catalytic residue [active] 91891006863 tellurite resistance protein TehB; Provisional; Region: PRK12335 91891006864 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 91891006865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006866 S-adenosylmethionine binding site [chemical binding]; other site 91891006867 Transcriptional regulator; Region: Rrf2; cl17282 91891006868 Rrf2 family protein; Region: rrf2_super; TIGR00738 91891006869 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 91891006870 apolar tunnel; other site 91891006871 heme binding site [chemical binding]; other site 91891006872 dimerization interface [polypeptide binding]; other site 91891006873 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 91891006874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 91891006875 catalytic loop [active] 91891006876 iron binding site [ion binding]; other site 91891006877 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 91891006878 FAD binding pocket [chemical binding]; other site 91891006879 FAD binding motif [chemical binding]; other site 91891006880 phosphate binding motif [ion binding]; other site 91891006881 beta-alpha-beta structure motif; other site 91891006882 NAD binding pocket [chemical binding]; other site 91891006883 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 91891006884 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 91891006885 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 91891006886 MltA specific insert domain; Region: MltA; smart00925 91891006887 3D domain; Region: 3D; pfam06725 91891006888 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 91891006889 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology 91891006890 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 91891006891 dimer interface [polypeptide binding]; other site 91891006892 putative tRNA-binding site [nucleotide binding]; other site 91891006893 EamA-like transporter family; Region: EamA; pfam00892 91891006894 EamA-like transporter family; Region: EamA; pfam00892 91891006895 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 91891006896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 91891006897 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 91891006898 putative active site pocket [active] 91891006899 dimerization interface [polypeptide binding]; other site 91891006900 putative catalytic residue [active] 91891006901 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 91891006902 EamA-like transporter family; Region: EamA; pfam00892 91891006903 EamA-like transporter family; Region: EamA; pfam00892 91891006904 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 91891006905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006906 putative substrate translocation pore; other site 91891006907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891006908 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 91891006909 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 91891006910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 91891006911 active site 91891006912 motif I; other site 91891006913 motif II; other site 91891006914 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 91891006915 Catalytic domain of Protein Kinases; Region: PKc; cd00180 91891006916 active site 91891006917 ATP binding site [chemical binding]; other site 91891006918 substrate binding site [chemical binding]; other site 91891006919 activation loop (A-loop); other site 91891006920 PAS domain; Region: PAS_9; pfam13426 91891006921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 91891006922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 91891006923 DNA binding residues [nucleotide binding] 91891006924 dimerization interface [polypeptide binding]; other site 91891006925 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891006926 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 91891006927 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 91891006928 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891006929 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 91891006930 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin 91891006931 Uncharacterized conserved protein [Function unknown]; Region: COG3189 91891006932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 91891006933 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 91891006934 active site 91891006935 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 91891006936 tetramer interface [polypeptide binding]; other site 91891006937 TPP-binding site [chemical binding]; other site 91891006938 heterodimer interface [polypeptide binding]; other site 91891006939 phosphorylation loop region [posttranslational modification] 91891006940 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 91891006941 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 91891006942 PYR/PP interface [polypeptide binding]; other site 91891006943 dimer interface [polypeptide binding]; other site 91891006944 TPP binding site [chemical binding]; other site 91891006945 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 91891006946 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 91891006947 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 91891006948 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 91891006949 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 91891006950 active site 91891006951 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 91891006952 active site 91891006953 catalytic triad [active] 91891006954 oxyanion hole [active] 91891006955 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 91891006956 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 91891006957 active site 91891006958 metal binding site [ion binding]; metal-binding site 91891006959 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 91891006960 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 91891006961 ParB-like nuclease domain; Region: ParBc; pfam02195 91891006962 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 91891006963 16S rRNA methyltransferase B; Provisional; Region: PRK10901 91891006964 NusB family; Region: NusB; pfam01029 91891006965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891006966 S-adenosylmethionine binding site [chemical binding]; other site 91891006967 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 91891006968 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 91891006969 putative active site [active] 91891006970 substrate binding site [chemical binding]; other site 91891006971 putative cosubstrate binding site; other site 91891006972 catalytic site [active] 91891006973 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 91891006974 substrate binding site [chemical binding]; other site 91891006975 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 91891006976 active site 91891006977 catalytic residues [active] 91891006978 metal binding site [ion binding]; metal-binding site 91891006979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891006980 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 91891006981 DNA protecting protein DprA; Region: dprA; TIGR00732 91891006982 Protein of unknown function (DUF494); Region: DUF494; pfam04361 91891006983 DNA topoisomerase I; Validated; Region: PRK06599 91891006984 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 91891006985 active site 91891006986 interdomain interaction site; other site 91891006987 putative metal-binding site [ion binding]; other site 91891006988 nucleotide binding site [chemical binding]; other site 91891006989 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 91891006990 domain I; other site 91891006991 DNA binding groove [nucleotide binding] 91891006992 phosphate binding site [ion binding]; other site 91891006993 domain II; other site 91891006994 domain III; other site 91891006995 nucleotide binding site [chemical binding]; other site 91891006996 catalytic site [active] 91891006997 domain IV; other site 91891006998 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 91891006999 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 91891007000 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 91891007001 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 91891007002 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 91891007003 Bacterial PH domain; Region: DUF304; pfam03703 91891007004 Protein of unknown function (DUF721); Region: DUF721; pfam05258 91891007005 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 91891007006 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 91891007007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 91891007008 Uncharacterized conserved protein [Function unknown]; Region: COG4278 91891007009 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 91891007010 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 91891007011 putative active site [active] 91891007012 putative dimer interface [polypeptide binding]; other site 91891007013 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 91891007014 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 91891007015 active site 91891007016 Zn binding site [ion binding]; other site 91891007017 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 91891007018 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 91891007019 cell division protein FtsZ; Validated; Region: PRK09330 91891007020 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 91891007021 nucleotide binding site [chemical binding]; other site 91891007022 SulA interaction site; other site 91891007023 cell division protein FtsA; Region: ftsA; TIGR01174 91891007024 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 91891007025 nucleotide binding site [chemical binding]; other site 91891007026 Cell division protein FtsA; Region: FtsA; pfam14450 91891007027 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 91891007028 Cell division protein FtsQ; Region: FtsQ; pfam03799 91891007029 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 91891007030 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 91891007031 ATP-grasp domain; Region: ATP-grasp_4; cl17255 91891007032 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 91891007033 FAD binding domain; Region: FAD_binding_4; pfam01565 91891007034 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 91891007035 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 91891007036 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 91891007037 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 91891007038 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 91891007039 cell division protein FtsW; Region: ftsW; TIGR02614 91891007040 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 91891007041 TrkA-N domain; Region: TrkA_N; pfam02254 91891007042 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 91891007043 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 91891007044 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 91891007045 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 91891007046 Mg++ binding site [ion binding]; other site 91891007047 putative catalytic motif [active] 91891007048 putative substrate binding site [chemical binding]; other site 91891007049 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 91891007050 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 91891007051 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 91891007052 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 91891007053 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 91891007054 FtsZ protein binding site [polypeptide binding]; other site 91891007055 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 91891007056 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 91891007057 Walker A/P-loop; other site 91891007058 ATP binding site [chemical binding]; other site 91891007059 Q-loop/lid; other site 91891007060 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 91891007061 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 91891007062 Q-loop/lid; other site 91891007063 ABC transporter signature motif; other site 91891007064 Walker B; other site 91891007065 D-loop; other site 91891007066 H-loop/switch region; other site 91891007067 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 91891007068 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 91891007069 active site 91891007070 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 91891007071 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 91891007072 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 91891007073 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 91891007074 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 91891007075 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 91891007076 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 91891007077 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 91891007078 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 91891007079 ATP-grasp domain; Region: ATP-grasp_4; cl17255 91891007080 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 91891007081 IMP binding site; other site 91891007082 dimer interface [polypeptide binding]; other site 91891007083 interdomain contacts; other site 91891007084 partial ornithine binding site; other site 91891007085 Predicted flavoproteins [General function prediction only]; Region: COG2081 91891007086 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 91891007087 Uncharacterized conserved protein [Function unknown]; Region: COG1434 91891007088 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 91891007089 putative active site [active] 91891007090 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 91891007091 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 91891007092 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 91891007093 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 91891007094 multifunctional aminopeptidase A; Provisional; Region: PRK00913 91891007095 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 91891007096 interface (dimer of trimers) [polypeptide binding]; other site 91891007097 Substrate-binding/catalytic site; other site 91891007098 Zn-binding sites [ion binding]; other site 91891007099 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 91891007100 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 91891007101 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 91891007102 interface (dimer of trimers) [polypeptide binding]; other site 91891007103 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 91891007104 Substrate-binding/catalytic site; other site 91891007105 Zn-binding sites [ion binding]; other site 91891007106 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 91891007107 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 91891007108 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 91891007109 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891007110 Sel1-like repeats; Region: SEL1; smart00671 91891007111 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891007112 Sel1-like repeats; Region: SEL1; smart00671 91891007113 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 91891007114 Sel1-like repeats; Region: SEL1; smart00671 91891007115 Sel1-like repeats; Region: SEL1; smart00671 91891007116 Sel1-like repeats; Region: SEL1; smart00671 91891007117 Sel1-like repeats; Region: SEL1; smart00671 91891007118 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 91891007119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 91891007120 putative active site [active] 91891007121 GAF domain; Region: GAF; pfam01590 91891007122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891007123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891007124 metal binding site [ion binding]; metal-binding site 91891007125 active site 91891007126 I-site; other site 91891007127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 91891007128 Transposase; Region: DEDD_Tnp_IS110; pfam01548 91891007129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 91891007130 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 91891007131 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 91891007132 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 91891007133 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 91891007134 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 91891007135 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 91891007136 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 91891007137 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 91891007138 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 91891007139 GIY-YIG motif/motif A; other site 91891007140 active site 91891007141 catalytic site [active] 91891007142 putative DNA binding site [nucleotide binding]; other site 91891007143 metal binding site [ion binding]; metal-binding site 91891007144 UvrB/uvrC motif; Region: UVR; pfam02151 91891007145 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 91891007146 response regulator; Provisional; Region: PRK09483 91891007147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891007148 active site 91891007149 phosphorylation site [posttranslational modification] 91891007150 intermolecular recognition site; other site 91891007151 dimerization interface [polypeptide binding]; other site 91891007152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 91891007153 DNA binding residues [nucleotide binding] 91891007154 dimerization interface [polypeptide binding]; other site 91891007155 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 91891007156 cofactor binding site; other site 91891007157 metal binding site [ion binding]; metal-binding site 91891007158 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 91891007159 competence damage-inducible protein A; Provisional; Region: PRK01215 91891007160 putative MPT binding site; other site 91891007161 GTPase CgtA; Reviewed; Region: obgE; PRK12299 91891007162 GTP1/OBG; Region: GTP1_OBG; pfam01018 91891007163 Obg GTPase; Region: Obg; cd01898 91891007164 G1 box; other site 91891007165 GTP/Mg2+ binding site [chemical binding]; other site 91891007166 Switch I region; other site 91891007167 G2 box; other site 91891007168 G3 box; other site 91891007169 Switch II region; other site 91891007170 G4 box; other site 91891007171 G5 box; other site 91891007172 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 91891007173 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 91891007174 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 91891007175 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 91891007176 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 91891007177 5S rRNA interface [nucleotide binding]; other site 91891007178 CTC domain interface [polypeptide binding]; other site 91891007179 L16 interface [polypeptide binding]; other site 91891007180 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 91891007181 putative active site [active] 91891007182 catalytic residue [active] 91891007183 GTP-binding protein YchF; Reviewed; Region: PRK09601 91891007184 YchF GTPase; Region: YchF; cd01900 91891007185 G1 box; other site 91891007186 GTP/Mg2+ binding site [chemical binding]; other site 91891007187 Switch I region; other site 91891007188 G2 box; other site 91891007189 Switch II region; other site 91891007190 G3 box; other site 91891007191 G4 box; other site 91891007192 G5 box; other site 91891007193 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 91891007194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 91891007195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 91891007196 metal binding site [ion binding]; metal-binding site 91891007197 active site 91891007198 I-site; other site 91891007199 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 91891007200 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 91891007201 substrate binding pocket [chemical binding]; other site 91891007202 chain length determination region; other site 91891007203 substrate-Mg2+ binding site; other site 91891007204 catalytic residues [active] 91891007205 aspartate-rich region 1; other site 91891007206 active site lid residues [active] 91891007207 aspartate-rich region 2; other site 91891007208 FeoC like transcriptional regulator; Region: FeoC; pfam09012 91891007209 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 91891007210 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 91891007211 G1 box; other site 91891007212 GTP/Mg2+ binding site [chemical binding]; other site 91891007213 Switch I region; other site 91891007214 G2 box; other site 91891007215 G3 box; other site 91891007216 Switch II region; other site 91891007217 G4 box; other site 91891007218 G5 box; other site 91891007219 Nucleoside recognition; Region: Gate; pfam07670 91891007220 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 91891007221 Nucleoside recognition; Region: Gate; pfam07670 91891007222 FeoA domain; Region: FeoA; pfam04023 91891007223 Predicted ATPase [General function prediction only]; Region: COG1485 91891007224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 91891007225 Walker A motif; other site 91891007226 ATP binding site [chemical binding]; other site 91891007227 Walker B motif; other site 91891007228 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 91891007229 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 91891007230 oligomerization interface [polypeptide binding]; other site 91891007231 active site 91891007232 metal binding site [ion binding]; metal-binding site 91891007233 pantoate--beta-alanine ligase; Region: panC; TIGR00018 91891007234 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 91891007235 active site 91891007236 nucleotide binding site [chemical binding]; other site 91891007237 HIGH motif; other site 91891007238 KMSKS motif; other site 91891007239 AAA domain; Region: AAA_28; pfam13521 91891007240 Predicted ATPase [General function prediction only]; Region: COG3911 91891007241 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 91891007242 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 91891007243 Dienelactone hydrolase family; Region: DLH; pfam01738 91891007244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 91891007245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891007246 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 91891007247 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 91891007248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 91891007249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 91891007250 DNA binding residues [nucleotide binding] 91891007251 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 91891007252 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 91891007253 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 91891007254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891007255 Walker A/P-loop; other site 91891007256 ATP binding site [chemical binding]; other site 91891007257 Q-loop/lid; other site 91891007258 ABC transporter signature motif; other site 91891007259 Walker B; other site 91891007260 D-loop; other site 91891007261 H-loop/switch region; other site 91891007262 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 91891007263 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 91891007264 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 91891007265 P loop; other site 91891007266 GTP binding site [chemical binding]; other site 91891007267 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 91891007268 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 91891007269 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 91891007270 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 91891007271 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 91891007272 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 91891007273 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 91891007274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007275 S-adenosylmethionine binding site [chemical binding]; other site 91891007276 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 91891007277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 91891007278 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 91891007279 Walker A motif; other site 91891007280 Walker A/P-loop; other site 91891007281 ATP binding site [chemical binding]; other site 91891007282 ATP binding site [chemical binding]; other site 91891007283 Walker B motif; other site 91891007284 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 91891007285 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 91891007286 putative active site [active] 91891007287 putative metal binding site [ion binding]; other site 91891007288 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 91891007289 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891007290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007291 S-adenosylmethionine binding site [chemical binding]; other site 91891007292 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 91891007293 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 91891007294 NAD binding site [chemical binding]; other site 91891007295 ATP-grasp domain; Region: ATP-grasp_4; cl17255 91891007296 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 91891007297 active site 91891007298 catalytic residues [active] 91891007299 metal binding site [ion binding]; metal-binding site 91891007300 tartrate dehydrogenase; Provisional; Region: PRK08194 91891007301 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 91891007302 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 91891007303 Dienelactone hydrolase family; Region: DLH; pfam01738 91891007304 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 91891007305 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 91891007306 Phagosome trafficking protein DotA; Region: DotA; pfam11388 91891007307 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 91891007308 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 91891007309 putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539 91891007310 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 91891007311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 91891007312 metal-binding site [ion binding] 91891007313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 91891007314 Methyltransferase domain; Region: Methyltransf_31; pfam13847 91891007315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007316 S-adenosylmethionine binding site [chemical binding]; other site 91891007317 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 91891007318 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 91891007319 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 91891007320 putative active site [active] 91891007321 Zinc-finger domain; Region: zf-CHCC; cl01821 91891007322 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 91891007323 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 91891007324 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 91891007325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891007326 ATP binding site [chemical binding]; other site 91891007327 Mg2+ binding site [ion binding]; other site 91891007328 G-X-G motif; other site 91891007329 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 91891007330 ATP binding site [chemical binding]; other site 91891007331 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 91891007332 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 91891007333 AMIN domain; Region: AMIN; pfam11741 91891007334 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 91891007335 active site 91891007336 metal binding site [ion binding]; metal-binding site 91891007337 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 91891007338 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 91891007339 putative carbohydrate kinase; Provisional; Region: PRK10565 91891007340 Uncharacterized conserved protein [Function unknown]; Region: COG0062 91891007341 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 91891007342 putative substrate binding site [chemical binding]; other site 91891007343 putative ATP binding site [chemical binding]; other site 91891007344 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 91891007345 stringent starvation protein A; Provisional; Region: sspA; PRK09481 91891007346 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 91891007347 C-terminal domain interface [polypeptide binding]; other site 91891007348 putative GSH binding site (G-site) [chemical binding]; other site 91891007349 dimer interface [polypeptide binding]; other site 91891007350 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 91891007351 dimer interface [polypeptide binding]; other site 91891007352 N-terminal domain interface [polypeptide binding]; other site 91891007353 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 91891007354 cytochrome b; Provisional; Region: CYTB; MTH00145 91891007355 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 91891007356 Qi binding site; other site 91891007357 intrachain domain interface; other site 91891007358 interchain domain interface [polypeptide binding]; other site 91891007359 heme bH binding site [chemical binding]; other site 91891007360 heme bL binding site [chemical binding]; other site 91891007361 Qo binding site; other site 91891007362 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 91891007363 interchain domain interface [polypeptide binding]; other site 91891007364 intrachain domain interface; other site 91891007365 Qi binding site; other site 91891007366 Qo binding site; other site 91891007367 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 91891007368 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 91891007369 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 91891007370 [2Fe-2S] cluster binding site [ion binding]; other site 91891007371 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 91891007372 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 91891007373 23S rRNA interface [nucleotide binding]; other site 91891007374 L3 interface [polypeptide binding]; other site 91891007375 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 91891007376 dimer interface [polypeptide binding]; other site 91891007377 [2Fe-2S] cluster binding site [ion binding]; other site 91891007378 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 91891007379 IHF - DNA interface [nucleotide binding]; other site 91891007380 IHF dimer interface [polypeptide binding]; other site 91891007381 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 91891007382 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 91891007383 putative tRNA-binding site [nucleotide binding]; other site 91891007384 B3/4 domain; Region: B3_4; pfam03483 91891007385 tRNA synthetase B5 domain; Region: B5; pfam03484 91891007386 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 91891007387 dimer interface [polypeptide binding]; other site 91891007388 motif 1; other site 91891007389 motif 3; other site 91891007390 motif 2; other site 91891007391 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 91891007392 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 91891007393 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 91891007394 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 91891007395 dimer interface [polypeptide binding]; other site 91891007396 motif 1; other site 91891007397 active site 91891007398 motif 2; other site 91891007399 motif 3; other site 91891007400 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 91891007401 23S rRNA binding site [nucleotide binding]; other site 91891007402 L21 binding site [polypeptide binding]; other site 91891007403 L13 binding site [polypeptide binding]; other site 91891007404 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 91891007405 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 91891007406 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 91891007407 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 91891007408 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 91891007409 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 91891007410 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 91891007411 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 91891007412 active site 91891007413 dimer interface [polypeptide binding]; other site 91891007414 motif 1; other site 91891007415 motif 2; other site 91891007416 motif 3; other site 91891007417 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 91891007418 anticodon binding site; other site 91891007419 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 91891007420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891007421 non-specific DNA binding site [nucleotide binding]; other site 91891007422 salt bridge; other site 91891007423 sequence-specific DNA binding site [nucleotide binding]; other site 91891007424 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 91891007425 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 91891007426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 91891007427 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 91891007428 ligand binding site [chemical binding]; other site 91891007429 flexible hinge region; other site 91891007430 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 91891007431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 91891007432 ligand binding site [chemical binding]; other site 91891007433 flexible hinge region; other site 91891007434 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 91891007435 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 91891007436 putative active site [active] 91891007437 putative dimer interface [polypeptide binding]; other site 91891007438 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 91891007439 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 91891007440 FMN binding site [chemical binding]; other site 91891007441 active site 91891007442 substrate binding site [chemical binding]; other site 91891007443 catalytic residue [active] 91891007444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 91891007445 dimerization interface [polypeptide binding]; other site 91891007446 putative DNA binding site [nucleotide binding]; other site 91891007447 putative Zn2+ binding site [ion binding]; other site 91891007448 Predicted membrane protein [Function unknown]; Region: COG2860 91891007449 UPF0126 domain; Region: UPF0126; pfam03458 91891007450 UPF0126 domain; Region: UPF0126; pfam03458 91891007451 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 91891007452 substrate binding site [chemical binding]; other site 91891007453 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 91891007454 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 91891007455 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 91891007456 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 91891007457 hypothetical protein; Provisional; Region: PRK07179 91891007458 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 91891007459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 91891007460 catalytic residue [active] 91891007461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891007462 active site 91891007463 phosphorylation site [posttranslational modification] 91891007464 intermolecular recognition site; other site 91891007465 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 91891007466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 91891007467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 91891007468 ATP binding site [chemical binding]; other site 91891007469 Mg2+ binding site [ion binding]; other site 91891007470 G-X-G motif; other site 91891007471 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 91891007472 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 91891007473 domain interfaces; other site 91891007474 active site 91891007475 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 91891007476 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 91891007477 active site 91891007478 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 91891007479 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 91891007480 HemY protein N-terminus; Region: HemY_N; pfam07219 91891007481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891007482 TPR motif; other site 91891007483 binding surface 91891007484 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 91891007485 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 91891007486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 91891007487 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 91891007488 catalytic site [active] 91891007489 putative active site [active] 91891007490 putative substrate binding site [chemical binding]; other site 91891007491 dimer interface [polypeptide binding]; other site 91891007492 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 91891007493 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 91891007494 active site 91891007495 NTP binding site [chemical binding]; other site 91891007496 metal binding triad [ion binding]; metal-binding site 91891007497 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 91891007498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 91891007499 Zn2+ binding site [ion binding]; other site 91891007500 Mg2+ binding site [ion binding]; other site 91891007501 GTPase RsgA; Reviewed; Region: PRK12288 91891007502 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 91891007503 RNA binding site [nucleotide binding]; other site 91891007504 homodimer interface [polypeptide binding]; other site 91891007505 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 91891007506 GTPase/Zn-binding domain interface [polypeptide binding]; other site 91891007507 GTP/Mg2+ binding site [chemical binding]; other site 91891007508 G4 box; other site 91891007509 G5 box; other site 91891007510 G1 box; other site 91891007511 Switch I region; other site 91891007512 G2 box; other site 91891007513 G3 box; other site 91891007514 Switch II region; other site 91891007515 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 91891007516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891007517 Walker A motif; other site 91891007518 ATP binding site [chemical binding]; other site 91891007519 Walker B motif; other site 91891007520 arginine finger; other site 91891007521 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 91891007522 hypothetical protein; Validated; Region: PRK00153 91891007523 recombination protein RecR; Reviewed; Region: recR; PRK00076 91891007524 RecR protein; Region: RecR; pfam02132 91891007525 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 91891007526 putative active site [active] 91891007527 putative metal-binding site [ion binding]; other site 91891007528 tetramer interface [polypeptide binding]; other site 91891007529 Protein of unknown function, DUF547; Region: DUF547; pfam04784 91891007530 Sulfatase; Region: Sulfatase; cl17466 91891007531 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 91891007532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 91891007533 active site 91891007534 dimerization interface [polypeptide binding]; other site 91891007535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 91891007536 DNA binding site [nucleotide binding] 91891007537 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 91891007538 Domain of unknown function DUF21; Region: DUF21; pfam01595 91891007539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 91891007540 Transporter associated domain; Region: CorC_HlyC; smart01091 91891007541 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 91891007542 dimer interface [polypeptide binding]; other site 91891007543 substrate binding site [chemical binding]; other site 91891007544 metal binding sites [ion binding]; metal-binding site 91891007545 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 91891007546 nucleotide binding site/active site [active] 91891007547 HIT family signature motif; other site 91891007548 catalytic residue [active] 91891007549 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 91891007550 GTP cyclohydrolase I; Provisional; Region: PLN03044 91891007551 homodecamer interface [polypeptide binding]; other site 91891007552 active site 91891007553 putative catalytic site residues [active] 91891007554 zinc binding site [ion binding]; other site 91891007555 GTP-CH-I/GFRP interaction surface; other site 91891007556 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 91891007557 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 91891007558 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 91891007559 RNase E interface [polypeptide binding]; other site 91891007560 trimer interface [polypeptide binding]; other site 91891007561 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 91891007562 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 91891007563 RNase E interface [polypeptide binding]; other site 91891007564 trimer interface [polypeptide binding]; other site 91891007565 active site 91891007566 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 91891007567 putative nucleic acid binding region [nucleotide binding]; other site 91891007568 G-X-X-G motif; other site 91891007569 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 91891007570 RNA binding site [nucleotide binding]; other site 91891007571 domain interface; other site 91891007572 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 91891007573 16S/18S rRNA binding site [nucleotide binding]; other site 91891007574 S13e-L30e interaction site [polypeptide binding]; other site 91891007575 25S rRNA binding site [nucleotide binding]; other site 91891007576 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 91891007577 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 91891007578 RNA binding site [nucleotide binding]; other site 91891007579 active site 91891007580 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 91891007581 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 91891007582 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 91891007583 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 91891007584 translation initiation factor IF-2; Region: IF-2; TIGR00487 91891007585 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 91891007586 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 91891007587 G1 box; other site 91891007588 putative GEF interaction site [polypeptide binding]; other site 91891007589 GTP/Mg2+ binding site [chemical binding]; other site 91891007590 Switch I region; other site 91891007591 G2 box; other site 91891007592 G3 box; other site 91891007593 Switch II region; other site 91891007594 G4 box; other site 91891007595 G5 box; other site 91891007596 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 91891007597 Translation-initiation factor 2; Region: IF-2; pfam11987 91891007598 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 91891007599 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 91891007600 NusA N-terminal domain; Region: NusA_N; pfam08529 91891007601 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 91891007602 RNA binding site [nucleotide binding]; other site 91891007603 homodimer interface [polypeptide binding]; other site 91891007604 NusA-like KH domain; Region: KH_5; pfam13184 91891007605 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 91891007606 G-X-X-G motif; other site 91891007607 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 91891007608 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 91891007609 ribosome maturation protein RimP; Reviewed; Region: PRK00092 91891007610 Sm and related proteins; Region: Sm_like; cl00259 91891007611 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 91891007612 putative oligomer interface [polypeptide binding]; other site 91891007613 putative RNA binding site [nucleotide binding]; other site 91891007614 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 91891007615 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 91891007616 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 91891007617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 91891007618 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 91891007619 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 91891007620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 91891007621 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 91891007622 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 91891007623 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 91891007624 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 91891007625 4Fe-4S binding domain; Region: Fer4; cl02805 91891007626 4Fe-4S binding domain; Region: Fer4; pfam00037 91891007627 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 91891007628 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 91891007629 NADH dehydrogenase subunit G; Validated; Region: PRK09129 91891007630 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 91891007631 catalytic loop [active] 91891007632 iron binding site [ion binding]; other site 91891007633 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 91891007634 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 91891007635 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 91891007636 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 91891007637 SLBB domain; Region: SLBB; pfam10531 91891007638 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 91891007639 NADH dehydrogenase subunit E; Validated; Region: PRK07539 91891007640 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 91891007641 putative dimer interface [polypeptide binding]; other site 91891007642 [2Fe-2S] cluster binding site [ion binding]; other site 91891007643 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 91891007644 NADH dehydrogenase subunit D; Validated; Region: PRK06075 91891007645 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 91891007646 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 91891007647 NADH dehydrogenase subunit B; Validated; Region: PRK06411 91891007648 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 91891007649 Preprotein translocase SecG subunit; Region: SecG; pfam03840 91891007650 triosephosphate isomerase; Provisional; Region: PRK14567 91891007651 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 91891007652 substrate binding site [chemical binding]; other site 91891007653 dimer interface [polypeptide binding]; other site 91891007654 catalytic triad [active] 91891007655 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 91891007656 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 91891007657 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 91891007658 active site 91891007659 substrate binding site [chemical binding]; other site 91891007660 metal binding site [ion binding]; metal-binding site 91891007661 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 91891007662 dihydropteroate synthase; Region: DHPS; TIGR01496 91891007663 substrate binding pocket [chemical binding]; other site 91891007664 dimer interface [polypeptide binding]; other site 91891007665 inhibitor binding site; inhibition site 91891007666 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 91891007667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891007668 Walker A motif; other site 91891007669 ATP binding site [chemical binding]; other site 91891007670 Walker B motif; other site 91891007671 arginine finger; other site 91891007672 Peptidase family M41; Region: Peptidase_M41; pfam01434 91891007673 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 91891007674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007675 S-adenosylmethionine binding site [chemical binding]; other site 91891007676 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 91891007677 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 91891007678 IucA / IucC family; Region: IucA_IucC; pfam04183 91891007679 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 91891007680 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 91891007681 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 91891007682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 91891007683 Walker A motif; other site 91891007684 ATP binding site [chemical binding]; other site 91891007685 Walker B motif; other site 91891007686 arginine finger; other site 91891007687 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 91891007688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891007689 putative substrate translocation pore; other site 91891007690 POT family; Region: PTR2; cl17359 91891007691 VIT family; Region: VIT1; pfam01988 91891007692 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 91891007693 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 91891007694 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 91891007695 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 91891007696 shikimate binding site; other site 91891007697 NAD(P) binding site [chemical binding]; other site 91891007698 aminopeptidase N; Provisional; Region: pepN; PRK14015 91891007699 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 91891007700 active site 91891007701 Zn binding site [ion binding]; other site 91891007702 PrkA family serine protein kinase; Provisional; Region: PRK15455 91891007703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 91891007704 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 91891007705 hypothetical protein; Provisional; Region: PRK05325 91891007706 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 91891007707 SpoVR family protein; Provisional; Region: PRK11767 91891007708 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 91891007709 Peptidase family M28; Region: Peptidase_M28; pfam04389 91891007710 active site 91891007711 metal binding site [ion binding]; metal-binding site 91891007712 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 91891007713 Part of AAA domain; Region: AAA_19; pfam13245 91891007714 Family description; Region: UvrD_C_2; pfam13538 91891007715 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 91891007716 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 91891007717 dimerization interface [polypeptide binding]; other site 91891007718 domain crossover interface; other site 91891007719 redox-dependent activation switch; other site 91891007720 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 91891007721 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 91891007722 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 91891007723 active site 91891007724 catalytic tetrad [active] 91891007725 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 91891007726 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 91891007727 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 91891007728 G1 box; other site 91891007729 putative GEF interaction site [polypeptide binding]; other site 91891007730 GTP/Mg2+ binding site [chemical binding]; other site 91891007731 Switch I region; other site 91891007732 G2 box; other site 91891007733 G3 box; other site 91891007734 Switch II region; other site 91891007735 G4 box; other site 91891007736 G5 box; other site 91891007737 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 91891007738 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 91891007739 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 91891007740 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 91891007741 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 91891007742 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 91891007743 Walker A/P-loop; other site 91891007744 ATP binding site [chemical binding]; other site 91891007745 Q-loop/lid; other site 91891007746 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 91891007747 ABC transporter signature motif; other site 91891007748 Walker B; other site 91891007749 D-loop; other site 91891007750 H-loop/switch region; other site 91891007751 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891007752 DNA-binding site [nucleotide binding]; DNA binding site 91891007753 RNA-binding motif; other site 91891007754 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 91891007755 conserved cys residue [active] 91891007756 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 91891007757 Amidinotransferase; Region: Amidinotransf; pfam02274 91891007758 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 91891007759 U-box domain; Region: U-box; cl17544 91891007760 U-box domain; Region: U-box; cl17544 91891007761 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 91891007762 active site 91891007763 nucleophile elbow; other site 91891007764 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 91891007765 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 91891007766 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 91891007767 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 91891007768 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 91891007769 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 91891007770 RNA binding site [nucleotide binding]; other site 91891007771 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 91891007772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007773 S-adenosylmethionine binding site [chemical binding]; other site 91891007774 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 91891007775 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 91891007776 glutaminase active site [active] 91891007777 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 91891007778 dimer interface [polypeptide binding]; other site 91891007779 active site 91891007780 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 91891007781 dimer interface [polypeptide binding]; other site 91891007782 active site 91891007783 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 91891007784 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 91891007785 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 91891007786 active site 91891007787 oxyanion hole [active] 91891007788 catalytic triad [active] 91891007789 rhodanese superfamily protein; Provisional; Region: PRK05320 91891007790 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 91891007791 active site residue [active] 91891007792 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 91891007793 SmpB-tmRNA interface; other site 91891007794 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 91891007795 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 91891007796 catalytic triad [active] 91891007797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 91891007798 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 91891007799 putative substrate translocation pore; other site 91891007800 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 91891007801 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 91891007802 putative active site [active] 91891007803 PhoH-like protein; Region: PhoH; pfam02562 91891007804 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 91891007805 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 91891007806 active site 91891007807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 91891007808 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 91891007809 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 91891007810 B1 nucleotide binding pocket [chemical binding]; other site 91891007811 B2 nucleotide binding pocket [chemical binding]; other site 91891007812 CAS motifs; other site 91891007813 active site 91891007814 TPR repeat; Region: TPR_11; pfam13414 91891007815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891007816 TPR motif; other site 91891007817 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 91891007818 Methyltransferase domain; Region: Methyltransf_24; pfam13578 91891007819 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 91891007820 DNA-binding site [nucleotide binding]; DNA binding site 91891007821 RNA-binding motif; other site 91891007822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 91891007823 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 91891007824 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 91891007825 Amidase; Region: Amidase; cl11426 91891007826 Oxygen tolerance; Region: BatD; pfam13584 91891007827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 91891007828 binding surface 91891007829 TPR motif; other site 91891007830 Tetratricopeptide repeat; Region: TPR_16; pfam13432 91891007831 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 91891007832 metal ion-dependent adhesion site (MIDAS); other site 91891007833 Aerotolerance regulator N-terminal; Region: BatA; cl06567 91891007834 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 91891007835 metal ion-dependent adhesion site (MIDAS); other site 91891007836 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 91891007837 Protein of unknown function DUF58; Region: DUF58; pfam01882 91891007838 MoxR-like ATPases [General function prediction only]; Region: COG0714 91891007839 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 91891007840 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 91891007841 FMN binding site [chemical binding]; other site 91891007842 active site 91891007843 catalytic residues [active] 91891007844 substrate binding site [chemical binding]; other site 91891007845 pteridine reductase; Provisional; Region: PRK09135 91891007846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 91891007847 NAD(P) binding site [chemical binding]; other site 91891007848 active site 91891007849 Uncharacterized conserved protein [Function unknown]; Region: COG1565 91891007850 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 91891007851 primosome assembly protein PriA; Validated; Region: PRK05580 91891007852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 91891007853 ATP binding site [chemical binding]; other site 91891007854 putative Mg++ binding site [ion binding]; other site 91891007855 nucleotide binding region [chemical binding]; other site 91891007856 helicase superfamily c-terminal domain; Region: HELICc; smart00490 91891007857 ATP-binding site [chemical binding]; other site 91891007858 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 91891007859 active site 91891007860 thymidylate synthase; Reviewed; Region: thyA; PRK01827 91891007861 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 91891007862 dimerization interface [polypeptide binding]; other site 91891007863 active site 91891007864 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 91891007865 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 91891007866 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 91891007867 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 91891007868 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 91891007869 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 91891007870 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 91891007871 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 91891007872 putative active site [active] 91891007873 Ap4A binding site [chemical binding]; other site 91891007874 nudix motif; other site 91891007875 putative metal binding site [ion binding]; other site 91891007876 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 91891007877 active site 91891007878 homodimer interface [polypeptide binding]; other site 91891007879 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 91891007880 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 91891007881 Substrate binding site; other site 91891007882 Mg++ binding site; other site 91891007883 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 91891007884 active site 91891007885 substrate binding site [chemical binding]; other site 91891007886 CoA binding site [chemical binding]; other site 91891007887 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 91891007888 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 91891007889 transmembrane helices; other site 91891007890 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 91891007891 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 91891007892 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 91891007893 oligomer interface [polypeptide binding]; other site 91891007894 metal binding site [ion binding]; metal-binding site 91891007895 metal binding site [ion binding]; metal-binding site 91891007896 Cl binding site [ion binding]; other site 91891007897 aspartate ring; other site 91891007898 basic sphincter; other site 91891007899 putative hydrophobic gate; other site 91891007900 periplasmic entrance; other site 91891007901 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 91891007902 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 91891007903 minor groove reading motif; other site 91891007904 helix-hairpin-helix signature motif; other site 91891007905 substrate binding pocket [chemical binding]; other site 91891007906 active site 91891007907 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 91891007908 ferredoxin; Provisional; Region: PRK08764 91891007909 Putative Fe-S cluster; Region: FeS; pfam04060 91891007910 4Fe-4S binding domain; Region: Fer4; pfam00037 91891007911 4Fe-4S binding domain; Region: Fer4; cl02805 91891007912 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 91891007913 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 91891007914 active site 91891007915 HIGH motif; other site 91891007916 KMSKS motif; other site 91891007917 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 91891007918 anticodon binding site; other site 91891007919 tRNA binding surface [nucleotide binding]; other site 91891007920 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 91891007921 dimer interface [polypeptide binding]; other site 91891007922 putative tRNA-binding site [nucleotide binding]; other site 91891007923 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 91891007924 Flavoprotein; Region: Flavoprotein; pfam02441 91891007925 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 91891007926 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 91891007927 Ligand Binding Site [chemical binding]; other site 91891007928 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 91891007929 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 91891007930 Substrate binding site; other site 91891007931 Cupin domain; Region: Cupin_2; cl17218 91891007932 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 91891007933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 91891007934 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 91891007935 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 91891007936 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 91891007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007938 S-adenosylmethionine binding site [chemical binding]; other site 91891007939 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 91891007940 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 91891007941 P-loop; other site 91891007942 Magnesium ion binding site [ion binding]; other site 91891007943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 91891007944 Magnesium ion binding site [ion binding]; other site 91891007945 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 91891007946 ParB-like nuclease domain; Region: ParBc; pfam02195 91891007947 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 91891007948 Subunit III/VIIa interface [polypeptide binding]; other site 91891007949 Phospholipid binding site [chemical binding]; other site 91891007950 Subunit I/III interface [polypeptide binding]; other site 91891007951 Subunit III/VIb interface [polypeptide binding]; other site 91891007952 Subunit III/VIa interface; other site 91891007953 Subunit III/Vb interface [polypeptide binding]; other site 91891007954 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 91891007955 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 91891007956 Subunit I/III interface [polypeptide binding]; other site 91891007957 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 91891007958 D-pathway; other site 91891007959 Subunit I/VIIc interface [polypeptide binding]; other site 91891007960 Subunit I/IV interface [polypeptide binding]; other site 91891007961 Subunit I/II interface [polypeptide binding]; other site 91891007962 Low-spin heme (heme a) binding site [chemical binding]; other site 91891007963 Subunit I/VIIa interface [polypeptide binding]; other site 91891007964 Subunit I/VIa interface [polypeptide binding]; other site 91891007965 Dimer interface; other site 91891007966 Putative water exit pathway; other site 91891007967 Binuclear center (heme a3/CuB) [ion binding]; other site 91891007968 K-pathway; other site 91891007969 Subunit I/Vb interface [polypeptide binding]; other site 91891007970 Putative proton exit pathway; other site 91891007971 Subunit I/VIb interface; other site 91891007972 Subunit I/VIc interface [polypeptide binding]; other site 91891007973 Electron transfer pathway; other site 91891007974 Subunit I/VIIIb interface [polypeptide binding]; other site 91891007975 Subunit I/VIIb interface [polypeptide binding]; other site 91891007976 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 91891007977 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00168 91891007978 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 91891007979 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 91891007980 Cytochrome c; Region: Cytochrom_C; pfam00034 91891007981 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 91891007982 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 91891007983 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 91891007984 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 91891007985 iron-sulfur cluster [ion binding]; other site 91891007986 [2Fe-2S] cluster binding site [ion binding]; other site 91891007987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 91891007988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 91891007989 Lysine efflux permease [General function prediction only]; Region: COG1279 91891007990 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 91891007991 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 91891007992 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 91891007993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891007994 S-adenosylmethionine binding site [chemical binding]; other site 91891007995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 91891007996 SCP-2 sterol transfer family; Region: SCP2; pfam02036 91891007997 SCP-2 sterol transfer family; Region: SCP2; cl01225 91891007998 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 91891007999 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 91891008000 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 91891008001 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 91891008002 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 91891008003 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 91891008004 methionine sulfoxide reductase A; Provisional; Region: PRK14054 91891008005 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 91891008006 tyramine oxidase; Provisional; Region: tynA; PRK11504 91891008007 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 91891008008 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 91891008009 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 91891008010 Serine carboxypeptidase; Region: Peptidase_S10; pfam00450 91891008011 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 91891008012 AAA domain; Region: AAA_14; pfam13173 91891008013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 91891008014 non-specific DNA binding site [nucleotide binding]; other site 91891008015 salt bridge; other site 91891008016 sequence-specific DNA binding site [nucleotide binding]; other site 91891008017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 91891008018 Transglycosylase SLT domain; Region: SLT_2; pfam13406 91891008019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 91891008020 N-acetyl-D-glucosamine binding site [chemical binding]; other site 91891008021 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 91891008022 Beta-lactamase; Region: Beta-lactamase; pfam00144 91891008023 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 91891008024 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 91891008025 active site 91891008026 NTP binding site [chemical binding]; other site 91891008027 metal binding triad [ion binding]; metal-binding site 91891008028 antibiotic binding site [chemical binding]; other site 91891008029 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 91891008030 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 91891008031 FtsX-like permease family; Region: FtsX; pfam02687 91891008032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 91891008033 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 91891008034 Walker A/P-loop; other site 91891008035 ATP binding site [chemical binding]; other site 91891008036 Q-loop/lid; other site 91891008037 ABC transporter signature motif; other site 91891008038 Walker B; other site 91891008039 D-loop; other site 91891008040 H-loop/switch region; other site 91891008041 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 91891008042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 91891008043 HlyD family secretion protein; Region: HlyD_3; pfam13437 91891008044 Outer membrane efflux protein; Region: OEP; pfam02321 91891008045 Outer membrane efflux protein; Region: OEP; pfam02321 91891008046 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 91891008047 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 91891008048 active site 91891008049 metal binding site [ion binding]; metal-binding site 91891008050 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 91891008051 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 91891008052 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 91891008053 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 91891008054 S-adenosylmethionine binding site [chemical binding]; other site 91891008055 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 91891008056 tetramerization interface [polypeptide binding]; other site 91891008057 active site 91891008058 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 91891008059 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 91891008060 FMN reductase; Validated; Region: fre; PRK08051 91891008061 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 91891008062 FAD binding pocket [chemical binding]; other site 91891008063 FAD binding motif [chemical binding]; other site 91891008064 phosphate binding motif [ion binding]; other site 91891008065 beta-alpha-beta structure motif; other site 91891008066 NAD binding pocket [chemical binding]; other site 91891008067 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 91891008068 transcription termination factor Rho; Provisional; Region: rho; PRK09376 91891008069 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 91891008070 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 91891008071 RNA binding site [nucleotide binding]; other site 91891008072 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 91891008073 multimer interface [polypeptide binding]; other site 91891008074 Walker A motif; other site 91891008075 ATP binding site [chemical binding]; other site 91891008076 Walker B motif; other site 91891008077 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 91891008078 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 91891008079 catalytic residues [active] 91891008080 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 91891008081 RNA methyltransferase, RsmE family; Region: TIGR00046 91891008082 fumarate hydratase; Reviewed; Region: fumC; PRK00485 91891008083 Class II fumarases; Region: Fumarase_classII; cd01362 91891008084 active site 91891008085 tetramer interface [polypeptide binding]; other site 91891008086 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 91891008087 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 91891008088 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 91891008089 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 91891008090 putative acyl-acceptor binding pocket; other site 91891008091 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 91891008092 putative acyl-acceptor binding pocket; other site 91891008093 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 91891008094 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 91891008095 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 91891008096 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 91891008097 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 91891008098 trimer interface [polypeptide binding]; other site 91891008099 active site 91891008100 UDP-GlcNAc binding site [chemical binding]; other site 91891008101 lipid binding site [chemical binding]; lipid-binding site 91891008102 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 91891008103 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 91891008104 active site 91891008105 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 91891008106 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 91891008107 Methyltransferase domain; Region: Methyltransf_23; pfam13489 91891008108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 91891008109 S-adenosylmethionine binding site [chemical binding]; other site 91891008110 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 91891008111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 91891008112 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 91891008113 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 91891008114 dimer interface [polypeptide binding]; other site 91891008115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891008116 catalytic residue [active] 91891008117 Histone methylation protein DOT1; Region: DOT1; pfam08123 91891008118 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 91891008119 IHF dimer interface [polypeptide binding]; other site 91891008120 IHF - DNA interface [nucleotide binding]; other site 91891008121 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 91891008122 trimer interface [polypeptide binding]; other site 91891008123 active site 91891008124 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 91891008125 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 91891008126 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 91891008127 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 91891008128 dimer interface [polypeptide binding]; other site 91891008129 active site residues [active] 91891008130 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 91891008131 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 91891008132 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 91891008133 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 91891008134 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 91891008135 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 91891008136 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 91891008137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 91891008138 ligand binding site [chemical binding]; other site 91891008139 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 91891008140 active site 91891008141 substrate binding pocket [chemical binding]; other site 91891008142 dimer interface [polypeptide binding]; other site 91891008143 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 91891008144 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 91891008145 dimer interface [polypeptide binding]; other site 91891008146 catalytic site [active] 91891008147 putative active site [active] 91891008148 putative substrate binding site [chemical binding]; other site 91891008149 peroxidase; Provisional; Region: PRK15000 91891008150 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 91891008151 dimer interface [polypeptide binding]; other site 91891008152 decamer (pentamer of dimers) interface [polypeptide binding]; other site 91891008153 catalytic triad [active] 91891008154 peroxidatic and resolving cysteines [active] 91891008155 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 91891008156 putative GSH binding site [chemical binding]; other site 91891008157 catalytic residues [active] 91891008158 superoxide dismutase; Provisional; Region: PRK10543 91891008159 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 91891008160 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 91891008161 acetylornithine aminotransferase; Provisional; Region: PRK02627 91891008162 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 91891008163 inhibitor-cofactor binding pocket; inhibition site 91891008164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 91891008165 catalytic residue [active] 91891008166 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 91891008167 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 91891008168 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 91891008169 active site 91891008170 catalytic site [active] 91891008171 malate dehydrogenase; Provisional; Region: PRK13529 91891008172 Malic enzyme, N-terminal domain; Region: malic; pfam00390 91891008173 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 91891008174 NAD(P) binding site [chemical binding]; other site 91891008175 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 91891008176 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 91891008177 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 91891008178 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 91891008179 Rossmann-like domain; Region: Rossmann-like; pfam10727 91891008180 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 91891008181 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 91891008182 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 91891008183 CAP-like domain; other site 91891008184 active site 91891008185 primary dimer interface [polypeptide binding]; other site 91891008186 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 91891008187 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 91891008188 gamma subunit interface [polypeptide binding]; other site 91891008189 LBP interface [polypeptide binding]; other site 91891008190 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 91891008191 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 91891008192 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 91891008193 alpha subunit interaction interface [polypeptide binding]; other site 91891008194 Walker A motif; other site 91891008195 ATP binding site [chemical binding]; other site 91891008196 Walker B motif; other site 91891008197 inhibitor binding site; inhibition site 91891008198 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 91891008199 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 91891008200 core domain interface [polypeptide binding]; other site 91891008201 delta subunit interface [polypeptide binding]; other site 91891008202 epsilon subunit interface [polypeptide binding]; other site 91891008203 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 91891008204 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 91891008205 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 91891008206 beta subunit interaction interface [polypeptide binding]; other site 91891008207 Walker A motif; other site 91891008208 ATP binding site [chemical binding]; other site 91891008209 Walker B motif; other site 91891008210 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 91891008211 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 91891008212 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 91891008213 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 91891008214 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 91891008215 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 91891008216 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 91891008217 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 91891008218 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 91891008219 outer membrane lipoprotein; Provisional; Region: PRK11023 91891008220 BON domain; Region: BON; pfam04972 91891008221 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 91891008222 BON domain; Region: BON; pfam04972 91891008223 BON domain; Region: BON; cl02771 91891008224 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 91891008225 dimer interface [polypeptide binding]; other site 91891008226 active site 91891008227 hypothetical protein; Reviewed; Region: PRK12497 91891008228 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 91891008229 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 91891008230 putative ligand binding site [chemical binding]; other site 91891008231 Predicted methyltransferases [General function prediction only]; Region: COG0313 91891008232 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 91891008233 putative SAM binding site [chemical binding]; other site 91891008234 putative homodimer interface [polypeptide binding]; other site 91891008235 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 91891008236 Fatty acid desaturase; Region: FA_desaturase; pfam00487 91891008237 Di-iron ligands [ion binding]; other site 91891008238 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 91891008239 Sulfate transporter family; Region: Sulfate_transp; pfam00916 91891008240 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 91891008241 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 91891008242 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 91891008243 ligand binding site [chemical binding]; other site 91891008244 flexible hinge region; other site 91891008245 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 91891008246 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 91891008247 active site 91891008248 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 91891008249 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 91891008250 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 91891008251 GTP/Mg2+ binding site [chemical binding]; other site 91891008252 G4 box; other site 91891008253 G5 box; other site 91891008254 trmE is a tRNA modification GTPase; Region: trmE; cd04164 91891008255 G1 box; other site 91891008256 G1 box; other site 91891008257 GTP/Mg2+ binding site [chemical binding]; other site 91891008258 Switch I region; other site 91891008259 Switch I region; other site 91891008260 G2 box; other site 91891008261 G2 box; other site 91891008262 Switch II region; other site 91891008263 G3 box; other site 91891008264 G4 box; other site 91891008265 G5 box; other site 91891008266 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 91891008267 membrane protein insertase; Provisional; Region: PRK01318 91891008268 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 91891008269 Ribonuclease P; Region: Ribonuclease_P; cl00457