-- dump date 20140619_130712 -- class Genbank::CDS -- table cds_note -- id note YP_061214.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_061215.1 binds the polymerase to DNA and acts as a sliding clamp YP_061216.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_061217.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_061218.1 identified by sequence similarity YP_061219.1 negatively supercoils closed circular double-stranded DNA YP_061220.1 negatively supercoils closed circular double-stranded DNA YP_061221.1 identified by sequence similarity YP_061222.1 identified by sequence similarity YP_061223.1 identified by sequence similarity YP_061225.1 identified by sequence similarity YP_061226.1 identified by sequence similarity YP_061227.1 identified by sequence similarity YP_061228.1 identified by sequence similarity YP_061229.1 identified by sequence similarity YP_061230.1 identified by sequence similarity YP_061231.1 identified by sequence similarity YP_061232.1 identified by sequence similarity YP_061233.1 identified by sequence similarity YP_061234.1 identified by sequence similarity YP_061235.1 identified by sequence similarity YP_061236.1 identified by sequence similarity YP_061237.1 identified by sequence similarity YP_061238.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_061239.1 identified by sequence similarity YP_061240.1 identified by sequence similarity YP_061241.1 identified by sequence similarity YP_061242.1 identified by sequence similarity YP_061243.1 identified by sequence similarity YP_061244.1 identified by sequence similarity YP_061245.1 identified by sequence similarity YP_061247.1 identified by sequence similarity YP_061248.1 identified by sequence similarity YP_061249.1 identified by sequence similarity YP_061250.1 identified by sequence similarity YP_061251.1 identified by sequence similarity YP_061252.1 identified by sequence similarity YP_061253.1 identified by sequence similarity YP_061254.1 identified by sequence similarity YP_061255.1 identified by sequence similarity YP_061256.1 identified by sequence similarity YP_061257.1 identified by sequence similarity YP_061259.1 identified by sequence similarity YP_061260.1 identified by sequence similarity YP_061261.1 identified by sequence similarity YP_061262.1 identified by sequence similarity YP_061265.1 identified by sequence similarity YP_061266.1 identified by sequence similarity YP_061268.1 identified by sequence similarity YP_061269.1 identified by sequence similarity YP_061271.1 identified by sequence similarity YP_061272.1 identified by sequence similarity YP_061273.1 identified by sequence similarity YP_061274.1 identified by sequence similarity YP_061275.1 identified by sequence similarity YP_061276.1 identified by sequence similarity YP_061277.1 identified by sequence similarity YP_061278.1 identified by sequence similarity YP_061279.1 identified by sequence similarity YP_061280.1 identified by sequence similarity YP_061281.1 identified by sequence similarity YP_061283.1 identified by sequence similarity YP_061284.1 identified by sequence similarity YP_061286.1 identified by sequence similarity YP_061291.1 identified by sequence similarity YP_061292.1 identified by sequence similarity YP_061293.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_061294.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_061295.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_061296.1 identified by sequence similarity YP_061298.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_061299.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_061300.1 identified by sequence similarity YP_061301.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_061302.1 identified by sequence similarity YP_061306.1 identified by sequence similarity YP_061307.1 identified by sequence similarity YP_061308.1 identified by sequence similarity YP_061311.1 identified by sequence similarity YP_061312.1 identified by sequence similarity YP_061313.1 identified by sequence similarity YP_061314.1 identified by sequence similarity YP_061315.1 identified by sequence similarity YP_061316.1 identified by sequence similarity YP_061317.1 identified by sequence similarity YP_061318.1 identified by sequence similarity YP_061319.1 identified by sequence similarity YP_061320.1 identified by sequence similarity YP_061321.1 identified by sequence similarity YP_061322.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_061323.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_061324.1 identified by sequence similarity YP_061325.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_061327.1 identified by sequence similarity YP_061328.1 identified by sequence similarity; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase YP_061329.1 identified by sequence similarity YP_061330.1 identified by sequence similarity YP_061331.1 identified by sequence similarity YP_061332.1 identified by sequence similarity YP_061333.1 identified by sequence similarity YP_061334.1 identified by sequence similarity YP_061335.1 identified by sequence similarity YP_061336.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_061337.1 identified by sequence similarity YP_061340.1 identified by sequence similarity YP_061341.1 identified by sequence similarity YP_061342.1 identified by sequence similarity YP_061343.1 identified by sequence similarity YP_061344.1 identified by sequence similarity YP_061345.1 identified by sequence similarity YP_061346.1 identified by sequence similarity YP_061347.1 identified by sequence similarity YP_061348.1 identified by sequence similarity YP_061349.1 identified by sequence similarity YP_061350.1 identified by sequence similarity YP_061351.1 identified by sequence similarity YP_061352.1 catalyzes the formation of menaquinol or 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol from S-adenosyl-L-methionine and demethylmenaquinol or 2-polyprenyl-6-methoxy-1,4-benzoquinol YP_061353.1 identified by sequence similarity YP_061354.1 identified by sequence similarity YP_061355.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_061356.1 identified by sequence similarity YP_061364.1 identified by sequence similarity YP_061365.1 identified by sequence similarity YP_061367.1 identified by sequence similarity YP_061369.1 identified by sequence similarity YP_061370.1 identified by sequence similarity YP_061371.1 identified by sequence similarity YP_061372.1 identified by sequence similarity YP_061373.1 identified by sequence similarity YP_061374.1 identified by sequence similarity YP_061375.1 identified by sequence similarity YP_061376.1 identified by sequence similarity YP_061377.1 identified by sequence similarity YP_061378.1 identified by sequence similarity YP_061379.1 identified by sequence similarity YP_061380.1 identified by sequence similarity YP_061382.1 identified by sequence similarity YP_061386.1 identified by sequence similarity YP_061387.1 identified by sequence similarity YP_061388.1 identified by sequence similarity YP_061389.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_061390.1 identified by sequence similarity YP_061391.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_061392.1 identified by sequence similarity YP_061393.1 identified by sequence similarity YP_061395.1 identified by sequence similarity YP_061396.1 identified by sequence similarity YP_061397.1 identified by sequence similarity YP_061398.1 identified by sequence similarity YP_061400.1 identified by sequence similarity YP_061401.1 identified by sequence similarity YP_061402.1 identified by sequence similarity YP_061403.1 identified by sequence similarity YP_061404.1 identified by sequence similarity YP_061405.1 identified by sequence similarity YP_061406.1 identified by sequence similarity YP_061407.1 identified by sequence similarity YP_061408.1 identified by sequence similarity YP_061409.1 identified by sequence similarity YP_061411.1 identified by sequence similarity YP_061412.1 identified by sequence similarity YP_061413.1 identified by sequence similarity YP_061414.1 identified by sequence similarity YP_061415.1 identified by sequence similarity YP_061416.1 identified by sequence similarity YP_061417.1 identified by sequence similarity YP_061418.1 identified by sequence similarity YP_061419.1 identified by sequence similarity YP_061420.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_061421.1 identified by sequence similarity YP_061422.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_061423.1 identified by sequence similarity YP_061424.1 binds directly to 23S ribosomal RNA YP_061425.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_061427.1 identified by sequence similarity YP_061429.1 identified by sequence similarity YP_061430.1 identified by sequence similarity YP_061431.1 identified by sequence similarity YP_061432.1 identified by sequence similarity YP_061433.1 identified by sequence similarity YP_061434.1 identified by sequence similarity YP_061435.1 identified by sequence similarity YP_061436.1 identified by sequence similarity YP_061437.1 identified by sequence similarity YP_061438.1 identified by sequence similarity YP_061439.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_061440.1 identified by sequence similarity YP_061443.1 identified by sequence similarity YP_061444.1 identified by sequence similarity YP_061445.1 identified by sequence similarity YP_061446.1 identified by sequence similarity YP_061447.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_061450.1 identified by sequence similarity YP_061451.1 identified by sequence similarity YP_061458.1 identified by sequence similarity YP_061459.1 catalyzes the interconversion of D-xylose to D-xylulose YP_061462.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_061463.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_061464.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_061465.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_061466.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_061467.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_061468.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_061469.1 identified by sequence similarity YP_061471.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_061472.1 identified by sequence similarity YP_061473.1 identified by sequence similarity YP_061474.1 identified by sequence similarity YP_061475.1 identified by sequence similarity YP_061476.1 identified by sequence similarity YP_061477.1 identified by sequence similarity YP_061478.1 identified by sequence similarity YP_061479.1 identified by sequence similarity YP_061480.1 identified by sequence similarity YP_061481.1 identified by sequence similarity YP_061484.1 identified by sequence similarity YP_061485.1 identified by sequence similarity YP_061488.1 identified by sequence similarity YP_061493.1 identified by sequence similarity YP_061494.1 identified by sequence similarity YP_061496.1 identified by sequence similarity YP_061498.1 identified by sequence similarity YP_061502.1 identified by sequence similarity YP_061503.1 identified by sequence similarity YP_061504.1 identified by sequence similarity YP_061505.1 identified by sequence similarity YP_061509.1 identified by sequence similarity YP_061510.1 identified by sequence similarity YP_061512.1 identified by sequence similarity YP_061514.1 identified by sequence similarity YP_061515.1 identified by sequence similarity YP_061516.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_061517.1 identified by sequence similarity YP_061518.1 identified by sequence similarity YP_061519.1 identified by sequence similarity YP_061522.1 penicillin binding protein; identified by sequence similarity YP_061523.1 identified by sequence similarity YP_061525.1 identified by sequence similarity YP_061526.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_061527.1 identified by sequence similarity YP_061528.1 identified by sequence similarity YP_061529.1 identified by sequence similarity YP_061530.1 identified by sequence similarity YP_061531.1 identified by sequence similarity YP_061533.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_061534.1 identified by sequence similarity; GTP cyclohydrolase II YP_061535.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_061536.1 bifunctional; identified by sequence similarity; riboflavin-specific reductase YP_061539.1 identified by sequence similarity YP_061540.1 identified by sequence similarity YP_061542.1 identified by sequence similarity YP_061543.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_061544.1 identified by sequence similarity YP_061545.1 identified by sequence similarity YP_061547.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_061548.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_061549.1 identified by sequence similarity YP_061550.1 identified by sequence similarity YP_061552.1 identified by sequence similarity YP_061553.1 identified by sequence similarity YP_061554.1 identified by sequence similarity YP_061555.1 identified by sequence similarity YP_061556.1 identified by sequence similarity YP_061557.1 identified by sequence similarity YP_061558.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_061559.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_061560.1 catalyzes the formation of inosine from adenosine YP_061561.1 identified by sequence similarity YP_061562.1 identified by sequence similarity YP_061563.1 identified by sequence similarity YP_061564.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_061565.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity YP_061566.1 identified by sequence similarity YP_061567.1 identified by sequence similarity YP_061568.1 identified by sequence similarity YP_061571.1 identified by sequence similarity YP_061572.1 identified by sequence similarity YP_061573.1 identified by sequence similarity YP_061574.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_061575.1 identified by sequence similarity YP_061577.1 identified by sequence similarity YP_061578.1 identified by sequence similarity YP_061579.1 identified by sequence similarity YP_061580.1 identified by sequence similarity YP_061581.1 identified by sequence similarity YP_061582.1 identified by sequence similarity YP_061583.1 identified by sequence similarity YP_061584.1 identified by sequence similarity YP_061585.1 identified by sequence similarity YP_061586.1 identified by sequence similarity YP_061587.1 identified by sequence similarity YP_061588.1 identified by sequence similarity YP_061589.1 identified by sequence similarity YP_061590.1 identified by sequence similarity YP_061592.1 identified by sequence similarity YP_061593.1 identified by sequence similarity YP_061594.1 identified by sequence similarity YP_061595.1 identified by sequence similarity YP_061596.1 identified by sequence similarity YP_061597.1 identified by sequence similarity YP_061598.1 identified by sequence similarity YP_061599.1 identified by sequence similarity YP_061600.1 identified by sequence similarity YP_061601.1 identified by sequence similarity YP_061602.1 identified by sequence similarity YP_061603.1 identified by sequence similarity YP_061604.1 identified by sequence similarity YP_061605.1 identified by sequence similarity YP_061607.1 identified by sequence similarity YP_061608.1 identified by sequence similarity YP_061609.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells YP_061610.1 identified by sequence similarity YP_061611.1 identified by sequence similarity YP_061612.1 identified by sequence similarity YP_061613.1 identified by sequence similarity YP_061614.1 identified by sequence similarity YP_061615.1 identified by sequence similarity YP_061616.1 identified by sequence similarity YP_061617.1 identified by sequence similarity YP_061618.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_061619.1 identified by sequence similarity YP_061620.1 identified by sequence similarity YP_061621.1 identified by sequence similarity YP_061622.1 identified by sequence similarity YP_061624.1 identified by sequence similarity YP_061625.1 identified by sequence similarity YP_061627.1 identified by sequence similarity YP_061628.1 identified by sequence similarity YP_061632.1 identified by sequence similarity YP_061633.1 catalyzes the phosphorylation of NAD to NADP YP_061634.1 identified by sequence similarity YP_061635.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_061636.1 identified by sequence similarity YP_061637.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_061638.1 identified by sequence similarity YP_061639.1 identified by sequence similarity YP_061640.1 identified by sequence similarity YP_061641.1 identified by sequence similarity YP_061642.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_061643.1 identified by sequence similarity YP_061644.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_061646.1 identified by sequence similarity YP_061647.1 identified by sequence similarity YP_061648.1 identified by sequence similarity YP_061649.1 identified by sequence similarity YP_061650.1 identified by sequence similarity YP_061652.1 identified by sequence similarity YP_061653.1 identified by sequence similarity YP_061654.1 identified by sequence similarity YP_061655.1 identified by sequence similarity YP_061656.1 identified by sequence similarity YP_061657.1 identified by sequence similarity YP_061658.1 identified by sequence similarity YP_061659.1 identified by sequence similarity YP_061660.1 identified by sequence similarity YP_061661.1 identified by sequence similarity YP_061662.1 identified by sequence similarity YP_061663.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_061664.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_061667.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_061668.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_061669.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_061670.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_061671.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_061672.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_061674.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_061677.1 identified by sequence similarity YP_061678.1 identified by sequence similarity YP_061680.1 identified by sequence similarity YP_061681.1 identified by sequence similarity YP_061683.1 identified by sequence similarity YP_061685.1 identified by sequence similarity YP_061686.1 identified by sequence similarity YP_061687.1 identified by sequence similarity YP_061690.1 identified by sequence similarity YP_061691.1 identified by sequence similarity YP_061692.1 identified by sequence similarity YP_061693.1 identified by sequence similarity YP_061695.1 identified by sequence similarity YP_061696.1 identified by sequence similarity YP_061698.1 identified by sequence similarity YP_061699.1 identified by sequence similarity YP_061700.1 identified by sequence similarity YP_061701.1 identified by sequence similarity YP_061702.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_061703.1 identified by sequence similarity YP_061704.1 identified by sequence similarity YP_061705.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_061706.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_061707.1 identified by sequence similarity YP_061708.1 identified by sequence similarity YP_061709.1 identified by sequence similarity YP_061711.1 identified by sequence similarity YP_061712.1 identified by sequence similarity YP_061713.1 identified by sequence similarity YP_061714.1 identified by sequence similarity YP_061715.1 identified by sequence similarity YP_061716.1 identified by sequence similarity YP_061717.1 identified by sequence similarity YP_061718.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_061719.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_061721.1 identified by sequence similarity YP_061722.1 identified by sequence similarity YP_061723.1 identified by sequence similarity YP_061724.1 identified by sequence similarity YP_061725.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_061726.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_061727.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_061728.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_061729.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_061730.1 identified by sequence similarity YP_061731.1 identified by sequence similarity YP_061732.1 identified by sequence similarity YP_061733.1 identified by sequence similarity YP_061734.1 identified by sequence similarity YP_061735.1 identified by sequence similarity YP_061736.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_061737.1 identified by sequence similarity YP_061738.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_061739.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_061740.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_061741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_061742.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_061743.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_061744.1 identified by sequence similarity YP_061745.1 identified by sequence similarity YP_061746.1 identified by sequence similarity YP_061747.1 identified by sequence similarity YP_061748.1 identified by sequence similarity YP_061749.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_061750.1 identified by sequence similarity YP_061751.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_061752.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_061753.1 identified by sequence similarity YP_061754.1 identified by sequence similarity YP_061755.1 identified by sequence similarity YP_061756.1 identified by sequence similarity YP_061757.1 identified by sequence similarity YP_061758.1 identified by sequence similarity YP_061759.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_061760.1 identified by sequence similarity YP_061761.1 identified by sequence similarity YP_061762.1 identified by sequence similarity YP_061763.1 identified by sequence similarity YP_061764.1 identified by sequence similarity YP_061765.1 identified by sequence similarity YP_061766.1 identified by sequence similarity YP_061767.1 identified by sequence similarity YP_061768.1 identified by sequence similarity YP_061769.1 identified by sequence similarity YP_061770.1 identified by sequence similarity YP_061771.1 identified by sequence similarity YP_061772.1 identified by sequence similarity YP_061773.1 identified by sequence similarity YP_061774.1 identified by sequence similarity YP_061775.1 identified by sequence similarity YP_061776.1 identified by sequence similarity YP_061777.1 identified by sequence similarity YP_061778.1 identified by sequence similarity YP_061779.1 identified by sequence similarity YP_061781.1 identified by sequence similarity YP_061782.1 identified by sequence similarity YP_061784.1 identified by sequence similarity YP_061789.1 identified by sequence similarity YP_061790.1 identified by sequence similarity YP_061791.1 identified by sequence similarity YP_061792.1 identified by sequence similarity YP_061793.1 identified by sequence similarity YP_061794.1 identified by sequence similarity YP_061795.1 identified by sequence similarity YP_061796.1 identified by sequence similarity YP_061798.1 identified by sequence similarity YP_061799.1 identified by sequence similarity YP_061800.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_061801.1 identified by sequence similarity YP_061802.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_061803.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_061804.1 binds and unfolds substrates as part of the ClpXP protease YP_061806.1 identified by sequence similarity YP_061807.1 identified by sequence similarity YP_061808.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_061809.1 identified by sequence similarity YP_061810.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_061811.1 identified by sequence similarity YP_061812.1 identified by sequence similarity YP_061813.1 identified by sequence similarity YP_061814.1 identified by sequence similarity YP_061815.1 identified by sequence similarity YP_061816.1 identified by sequence similarity YP_061817.2 identified by sequence similarity YP_061818.1 involved in the peptidyltransferase reaction during translation YP_061819.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_061820.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_061821.1 identified by sequence similarity YP_061823.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_061824.1 identified by sequence similarity YP_061825.1 identified by sequence similarity YP_061826.1 identified by sequence similarity YP_061827.1 identified by sequence similarity YP_061828.1 identified by sequence similarity YP_061829.1 identified by sequence similarity YP_061830.1 identified by sequence similarity YP_061831.1 identified by sequence similarity YP_061832.1 identified by sequence similarity YP_061833.1 identified by sequence similarity YP_061834.1 identified by sequence similarity YP_061835.1 identified by sequence similarity YP_061836.1 identified by sequence similarity YP_061837.1 identified by sequence similarity YP_061838.1 identified by sequence similarity YP_061839.1 identified by sequence similarity YP_061840.1 identified by sequence similarity YP_061841.1 identified by sequence similarity YP_061842.1 identified by sequence similarity YP_061843.1 identified by sequence similarity YP_061844.1 identified by sequence similarity YP_061846.1 identified by sequence similarity YP_061847.1 identified by sequence similarity YP_061848.1 identified by sequence similarity YP_061849.1 identified by sequence similarity YP_061850.1 identified by sequence similarity YP_061851.1 identified by sequence similarity YP_061852.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_061854.1 synthesizes RNA primers at the replication forks YP_061855.1 identified by sequence similarity YP_061856.1 identified by sequence similarity YP_061857.1 identified by sequence similarity YP_061858.1 identified by sequence similarity YP_061859.1 identified by sequence similarity YP_061860.1 identified by sequence similarity YP_061861.1 identified by sequence similarity YP_061862.1 identified by sequence similarity YP_061863.1 identified by sequence similarity YP_061864.1 identified by sequence similarity YP_061865.1 identified by sequence similarity YP_061866.1 identified by sequence similarity YP_061867.1 identified by sequence similarity YP_061868.1 identified by sequence similarity YP_061869.1 identified by sequence similarity YP_061870.1 identified by sequence similarity YP_061871.1 identified by sequence similarity YP_061872.1 identified by sequence similarity YP_061873.1 identified by sequence similarity YP_061874.1 identified by sequence similarity YP_061875.1 identified by sequence similarity YP_061876.1 identified by sequence similarity YP_061877.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_061878.1 identified by sequence similarity YP_061879.1 identified by sequence similarity YP_061880.1 identified by sequence similarity YP_061881.1 identified by sequence similarity YP_061882.1 identified by sequence similarity YP_061885.1 identified by sequence similarity YP_061886.1 identified by sequence similarity YP_061888.1 identified by sequence similarity YP_061889.1 identified by sequence similarity YP_061890.1 identified by sequence similarity YP_061891.1 catalyzes the formation of fumarate from aspartate YP_061892.1 identified by sequence similarity YP_061893.1 identified by sequence similarity YP_061894.1 identified by sequence similarity YP_061895.1 identified by sequence similarity YP_061896.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_061897.1 identified by sequence similarity YP_061898.1 identified by sequence similarity YP_061899.1 identified by sequence similarity YP_061900.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate YP_061901.1 identified by sequence similarity YP_061902.1 identified by sequence similarity YP_061903.1 identified by sequence similarity YP_061905.1 identified by sequence similarity YP_061906.1 identified by sequence similarity YP_061907.1 identified by sequence similarity YP_061908.1 identified by sequence similarity YP_061909.1 identified by sequence similarity YP_061910.1 identified by sequence similarity YP_061911.1 identified by sequence similarity YP_061912.1 identified by sequence similarity YP_061913.1 identified by sequence similarity YP_061915.1 identified by sequence similarity YP_061916.1 identified by sequence similarity YP_061917.1 identified by sequence similarity YP_061918.1 identified by sequence similarity YP_061919.1 identified by sequence similarity YP_061920.1 identified by sequence similarity YP_061922.1 identified by sequence similarity YP_061923.1 identified by sequence similarity YP_061924.1 identified by sequence similarity YP_061925.1 identified by sequence similarity YP_061926.1 identified by sequence similarity YP_061927.1 identified by sequence similarity YP_061928.1 identified by sequence similarity YP_061929.1 identified by sequence similarity YP_061930.1 identified by sequence similarity YP_061931.1 identified by sequence similarity YP_061932.1 identified by sequence similarity YP_061934.1 identified by sequence similarity YP_061935.1 identified by sequence similarity YP_061936.1 identified by sequence similarity YP_061937.1 identified by sequence similarity YP_061938.1 identified by sequence similarity YP_061939.1 identified by sequence similarity YP_061940.1 identified by sequence similarity YP_061941.1 identified by sequence similarity YP_061942.1 identified by sequence similarity YP_061943.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_061944.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_061945.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_061946.1 identified by sequence similarity YP_061947.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_061948.1 identified by sequence similarity YP_061949.1 identified by sequence similarity YP_061950.1 identified by sequence similarity YP_061951.1 identified by sequence similarity YP_061952.1 identified by sequence similarity YP_061953.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_061954.1 identified by sequence similarity YP_061955.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_061956.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_061957.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_061958.1 identified by sequence similarity YP_061959.1 identified by sequence similarity YP_061960.1 identified by sequence similarity YP_061961.1 identified by sequence similarity YP_061962.1 identified by sequence similarity YP_061963.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_061964.1 identified by sequence similarity YP_061965.1 identified by sequence similarity YP_061966.1 identified by sequence similarity YP_061967.1 identified by sequence similarity YP_061968.1 identified by sequence similarity YP_061969.1 identified by sequence similarity YP_061970.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_061971.1 identified by sequence similarity YP_061972.1 identified by sequence similarity YP_061973.1 identified by sequence similarity YP_061974.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_061976.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_061977.1 identified by sequence similarity YP_061978.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_061979.1 identified by sequence similarity YP_061980.1 identified by sequence similarity YP_061981.1 identified by sequence similarity YP_061982.1 identified by sequence similarity YP_061983.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_061984.1 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism YP_061985.1 identified by sequence similarity YP_061986.1 identified by sequence similarity YP_061987.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_061988.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_061989.1 identified by sequence similarity YP_061990.1 identified by sequence similarity YP_061991.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_061992.1 identified by sequence similarity YP_061993.1 identified by sequence similarity YP_061994.1 identified by sequence similarity YP_061995.1 identified by sequence similarity YP_061996.1 identified by sequence similarity YP_061997.1 identified by sequence similarity YP_061998.1 identified by sequence similarity YP_062001.1 identified by sequence similarity YP_062002.1 identified by sequence similarity YP_062003.1 identified by sequence similarity YP_062004.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_062005.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_062006.1 identified by sequence similarity YP_062007.1 identified by sequence similarity YP_062008.1 identified by sequence similarity YP_062009.1 identified by sequence similarity YP_062010.1 identified by sequence similarity YP_062011.1 identified by sequence similarity YP_062012.1 identified by sequence similarity YP_062013.1 identified by sequence similarity YP_062014.1 Catalyzes the conversion of citrate to isocitrate YP_062015.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_062016.1 identified by sequence similarity YP_062017.1 identified by sequence similarity YP_062018.1 identified by sequence similarity YP_062019.1 identified by sequence similarity YP_062020.1 identified by sequence similarity YP_062021.1 identified by sequence similarity YP_062022.1 identified by sequence similarity YP_062023.1 identified by sequence similarity YP_062024.1 identified by sequence similarity YP_062025.1 identified by sequence similarity YP_062026.1 identified by sequence similarity YP_062027.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_062028.1 identified by sequence similarity YP_062029.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_062030.1 identified by sequence similarity YP_062031.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_062032.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_062033.1 identified by sequence similarity YP_062034.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_062035.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_062036.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_062037.1 identified by sequence similarity YP_062038.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_062039.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_062040.1 identified by sequence similarity YP_062041.1 identified by sequence similarity YP_062042.1 identified by sequence similarity YP_062043.1 identified by sequence similarity YP_062044.1 identified by sequence similarity YP_062045.1 identified by sequence similarity YP_062046.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_062047.1 identified by sequence similarity YP_062048.1 identified by sequence similarity YP_062049.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_062050.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_062051.1 identified by sequence similarity YP_062052.1 identified by sequence similarity YP_062053.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_062054.1 identified by sequence similarity YP_062055.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_062057.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_062058.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_062059.1 identified by sequence similarity YP_062060.1 shows similarity to disulfide isomerases YP_062061.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_062062.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_062063.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_062065.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_062066.1 identified by sequence similarity YP_062067.1 identified by sequence similarity YP_062068.1 identified by sequence similarity YP_062069.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_062070.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_062071.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_062072.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_062073.1 identified by sequence similarity YP_062074.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_062075.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_062076.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_062077.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_062078.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_062079.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_062080.1 identified by sequence similarity YP_062081.1 identified by sequence similarity YP_062082.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_062083.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_062084.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_062085.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_062086.1 identified by sequence similarity YP_062087.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_062088.1 identified by sequence similarity YP_062089.1 identified by sequence similarity YP_062092.1 identified by sequence similarity YP_062093.1 identified by sequence similarity YP_062094.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_062095.1 identified by sequence similarity YP_062096.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_062097.1 identified by sequence similarity YP_062098.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_062100.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_062101.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_062102.1 identified by sequence similarity YP_062103.1 identified by sequence similarity YP_062104.1 identified by sequence similarity YP_062105.1 identified by sequence similarity YP_062106.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_062107.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_062108.1 identified by sequence similarity YP_062109.1 identified by sequence similarity YP_062110.1 identified by sequence similarity YP_062111.1 identified by sequence similarity YP_062112.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_062113.1 identified by sequence similarity YP_062114.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_062115.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_062116.1 converts protoheme IX and farnesyl diphosphate to heme O YP_062117.1 identified by sequence similarity YP_062118.1 identified by sequence similarity YP_062119.1 identified by sequence similarity YP_062120.1 identified by sequence similarity YP_062121.1 identified by sequence similarity YP_062122.1 identified by sequence similarity YP_062123.1 identified by sequence similarity YP_062124.1 identified by sequence similarity YP_062125.1 identified by sequence similarity YP_062126.1 identified by sequence similarity YP_062127.1 identified by sequence similarity YP_062128.1 identified by sequence similarity YP_062129.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_062130.1 identified by sequence similarity YP_062131.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_062132.1 identified by sequence similarity YP_062133.1 3'-5' exonuclease of DNA polymerase III YP_062134.1 identified by sequence similarity YP_062135.1 identified by sequence similarity YP_062136.1 identified by sequence similarity YP_062137.1 identified by sequence similarity YP_062138.1 identified by sequence similarity YP_062139.1 identified by sequence similarity YP_062140.1 identified by sequence similarity YP_062141.1 identified by sequence similarity YP_062143.1 identified by sequence similarity YP_062144.1 identified by sequence similarity YP_062145.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_062146.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_062147.1 identified by sequence similarity YP_062148.1 identified by sequence similarity YP_062149.1 identified by sequence similarity YP_062150.1 identified by sequence similarity YP_062151.1 identified by sequence similarity YP_062152.1 identified by sequence similarity YP_062153.1 identified by sequence similarity YP_062154.1 identified by sequence similarity YP_062155.1 identified by sequence similarity YP_062156.1 identified by sequence similarity YP_062157.1 identified by sequence similarity YP_062158.1 identified by sequence similarity YP_062159.1 identified by sequence similarity YP_062160.1 identified by sequence similarity YP_062161.1 identified by sequence similarity YP_062162.1 identified by sequence similarity YP_062163.1 identified by sequence similarity YP_062164.1 identified by sequence similarity YP_062165.1 identified by sequence similarity YP_062166.1 identified by sequence similarity YP_062167.1 identified by sequence similarity YP_062168.1 identified by sequence similarity YP_062169.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_062170.1 identified by sequence similarity YP_062171.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_062172.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_062173.1 identified by sequence similarity YP_062174.1 identified by sequence similarity YP_062175.1 identified by sequence similarity YP_062176.1 identified by sequence similarity YP_062177.1 identified by sequence similarity YP_062178.1 identified by sequence similarity YP_062179.1 identified by sequence similarity YP_062180.1 identified by sequence similarity YP_062181.1 identified by sequence similarity YP_062182.1 identified by sequence similarity YP_062183.1 identified by sequence similarity YP_062184.1 identified by sequence similarity YP_062185.1 identified by sequence similarity YP_062186.1 identified by sequence similarity YP_062187.1 identified by sequence similarity YP_062188.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_062189.1 identified by sequence similarity YP_062190.1 identified by sequence similarity YP_062192.1 identified by sequence similarity YP_062193.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_062194.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_062195.1 Catalyzes the phosphorylation of UMP to UDP YP_062196.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_062197.1 identified by sequence similarity YP_062198.1 identified by sequence similarity YP_062199.1 identified by sequence similarity YP_062200.1 identified by sequence similarity YP_062201.1 identified by sequence similarity YP_062202.1 identified by sequence similarity YP_062203.1 identified by sequence similarity YP_062204.1 identified by sequence similarity YP_062205.1 identified by sequence similarity YP_062206.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_062207.1 identified by sequence similarity YP_062210.1 identified by sequence similarity YP_062213.1 identified by sequence similarity YP_062214.1 identified by sequence similarity YP_062215.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_062216.1 identified by sequence similarity YP_062217.1 identified by sequence similarity YP_062218.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_062219.1 carries the fatty acid chain in fatty acid biosynthesis YP_062220.1 identified by sequence similarity YP_062221.1 identified by sequence similarity YP_062222.1 identified by sequence similarity YP_062223.1 identified by sequence similarity YP_062225.1 identified by sequence similarity YP_062226.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_062228.1 identified by sequence similarity YP_062229.1 identified by sequence similarity YP_062231.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_062232.1 identified by sequence similarity YP_062233.1 identified by sequence similarity YP_062235.1 identified by sequence similarity YP_062239.1 identified by sequence similarity YP_062240.1 identified by sequence similarity YP_062241.1 identified by sequence similarity YP_062243.1 identified by sequence similarity YP_062244.1 identified by sequence similarity YP_062245.1 identified by sequence similarity YP_062246.1 identified by sequence similarity YP_062247.1 identified by sequence similarity YP_062248.1 identified by sequence similarity YP_062249.1 identified by sequence similarity YP_062250.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_062251.1 identified by sequence similarity YP_062252.1 identified by sequence similarity YP_062253.1 identified by sequence similarity YP_062254.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_062255.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_062256.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_062258.1 identified by sequence similarity YP_062259.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_062260.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_062261.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_062262.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_062263.1 identified by sequence similarity YP_062264.1 identified by sequence similarity YP_062265.1 identified by sequence similarity YP_062266.1 identified by sequence similarity YP_062268.1 identified by sequence similarity YP_062269.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_062270.1 identified by sequence similarity YP_062271.1 identified by sequence similarity YP_062274.1 identified by sequence similarity YP_062275.1 identified by sequence similarity YP_062276.1 identified by sequence similarity YP_062277.1 identified by sequence similarity YP_062278.1 catalyzes the formation of inosine from adenosine YP_062279.1 identified by sequence similarity YP_062280.1 identified by sequence similarity YP_062281.1 identified by sequence similarity YP_062283.1 identified by sequence similarity YP_062284.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_062285.1 identified by sequence similarity YP_062286.1 identified by sequence similarity YP_062287.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_062288.1 identified by sequence similarity YP_062290.1 identified by sequence similarity YP_062291.1 identified by sequence similarity YP_062292.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_062293.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_062294.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_062295.1 identified by sequence similarity YP_062296.1 identified by sequence similarity YP_062297.1 identified by sequence similarity YP_062298.1 identified by sequence similarity YP_062299.1 identified by sequence similarity YP_062301.1 identified by sequence similarity YP_062302.1 identified by sequence similarity YP_062303.1 identified by sequence similarity YP_062304.1 identified by sequence similarity YP_062305.1 identified by sequence similarity YP_062306.1 identified by sequence similarity YP_062307.1 identified by sequence similarity YP_062308.1 identified by sequence similarity YP_062310.1 identified by sequence similarity YP_062311.1 identified by sequence similarity YP_062312.1 identified by sequence similarity YP_062315.1 identified by sequence similarity YP_062316.1 identified by sequence similarity YP_062317.1 identified by sequence similarity YP_062320.1 identified by sequence similarity YP_062323.1 identified by sequence similarity YP_062325.1 identified by sequence similarity YP_062326.1 identified by sequence similarity YP_062327.1 identified by sequence similarity YP_062328.1 identified by sequence similarity YP_062329.1 identified by sequence similarity YP_062330.1 identified by sequence similarity YP_062332.1 identified by sequence similarity YP_062333.1 identified by sequence similarity YP_062335.1 identified by sequence similarity YP_062336.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_062337.1 identified by sequence similarity YP_062338.1 identified by sequence similarity YP_062339.1 identified by sequence similarity YP_062340.1 identified by sequence similarity YP_062342.1 identified by sequence similarity YP_062343.1 identified by sequence similarity YP_062344.1 identified by sequence similarity YP_062345.1 identified by sequence similarity YP_062346.1 identified by sequence similarity YP_062347.1 identified by sequence similarity YP_062348.1 identified by sequence similarity YP_062349.1 identified by sequence similarity YP_062350.1 identified by sequence similarity YP_062351.1 identified by sequence similarity YP_062352.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_062353.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_062354.1 identified by sequence similarity YP_062355.1 identified by sequence similarity YP_062356.2 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_062357.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_062359.1 identified by sequence similarity YP_062360.1 identified by sequence similarity YP_062361.1 identified by sequence similarity YP_062363.1 identified by sequence similarity YP_062364.1 identified by sequence similarity YP_062365.1 identified by sequence similarity YP_062366.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_062367.1 identified by sequence similarity YP_062368.2 identified by sequence similarity YP_062369.1 identified by sequence similarity YP_062370.1 identified by sequence similarity YP_062371.1 identified by sequence similarity YP_062372.1 identified by sequence similarity YP_062373.1 identified by sequence similarity YP_062374.1 identified by sequence similarity YP_062375.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_062376.1 identified by sequence similarity YP_062377.1 identified by sequence similarity YP_062378.1 identified by sequence similarity YP_062379.1 identified by sequence similarity YP_062380.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_062381.1 identified by sequence similarity YP_062382.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_062383.1 identified by sequence similarity YP_062384.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_062385.1 identified by sequence similarity YP_062386.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_062387.1 identified by sequence similarity YP_062388.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_062389.1 identified by sequence similarity YP_062390.1 identified by sequence similarity YP_062391.1 identified by sequence similarity YP_062392.1 identified by sequence similarity YP_062393.1 identified by sequence similarity YP_062394.1 identified by sequence similarity YP_062395.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_062396.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_062397.1 identified by sequence similarity YP_062398.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_062399.1 identified by sequence similarity YP_062400.1 identified by sequence similarity YP_062401.1 Essential for efficient processing of 16S rRNA YP_062402.1 identified by sequence similarity YP_062403.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_062404.1 identified by sequence similarity YP_062405.1 identified by sequence similarity YP_062406.1 identified by sequence similarity YP_062407.1 identified by sequence similarity YP_062408.1 identified by sequence similarity YP_062410.1 identified by sequence similarity YP_062411.1 identified by sequence similarity YP_062412.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_062413.1 identified by sequence similarity YP_062414.1 identified by sequence similarity YP_062415.1 identified by sequence similarity YP_062416.1 identified by sequence similarity YP_062417.1 identified by sequence similarity YP_062418.1 identified by sequence similarity YP_062419.1 identified by sequence similarity YP_062420.1 identified by sequence similarity YP_062421.1 identified by sequence similarity YP_062422.1 catalyzes the endonucleolytic cleavage to 5'-phosphomonomer YP_062423.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_062424.1 identified by sequence similarity YP_062425.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_062426.1 identified by sequence similarity YP_062427.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_062428.1 identified by sequence similarity YP_062429.1 identified by sequence similarity YP_062430.1 identified by sequence similarity YP_062431.1 identified by sequence similarity YP_062432.1 identified by sequence similarity YP_062433.1 identified by sequence similarity YP_062434.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_062435.1 identified by sequence similarity YP_062436.1 identified by sequence similarity YP_062437.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_062438.1 identified by sequence similarity YP_062439.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_062440.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_062441.1 identified by sequence similarity YP_062442.1 identified by sequence similarity YP_062443.1 identified by sequence similarity YP_062444.1 identified by sequence similarity YP_062445.1 identified by sequence similarity YP_062446.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_062447.1 identified by sequence similarity YP_062448.1 identified by sequence similarity YP_062449.1 identified by sequence similarity YP_062450.1 identified by sequence similarity YP_062451.1 identified by sequence similarity YP_062452.1 identified by sequence similarity YP_062453.1 identified by sequence similarity YP_062454.1 identified by sequence similarity YP_062455.1 identified by sequence similarity YP_062456.1 identified by sequence similarity YP_062457.1 identified by sequence similarity YP_062458.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_062459.1 identified by sequence similarity YP_062460.1 identified by sequence similarity YP_062461.1 identified by sequence similarity YP_062462.1 identified by sequence similarity YP_062463.1 identified by sequence similarity YP_062464.1 identified by sequence similarity YP_062465.1 identified by sequence similarity YP_062466.1 identified by sequence similarity YP_062467.1 identified by sequence similarity YP_062468.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_062469.1 identified by sequence similarity YP_062470.1 identified by sequence similarity YP_062471.1 identified by sequence similarity YP_062472.1 identified by sequence similarity YP_062473.1 identified by sequence similarity YP_062474.1 identified by sequence similarity YP_062475.1 identified by sequence similarity YP_062477.1 identified by sequence similarity YP_062478.1 identified by sequence similarity YP_062479.1 identified by sequence similarity YP_062480.1 identified by sequence similarity YP_062481.1 identified by sequence similarity YP_062482.1 identified by sequence similarity YP_062484.1 identified by sequence similarity YP_062485.1 identified by sequence similarity YP_062486.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis YP_062487.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_062488.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_062489.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_062490.1 identified by sequence similarity YP_062491.1 Represses a number of genes involved in the response to DNA damage YP_062492.1 identified by sequence similarity YP_062493.1 identified by sequence similarity YP_062494.1 identified by sequence similarity YP_062495.1 identified by sequence similarity YP_062496.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_062497.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_062498.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_062501.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_062502.1 identified by sequence similarity YP_062503.1 identified by sequence similarity YP_062504.1 identified by sequence similarity YP_062505.1 identified by sequence similarity YP_062506.1 identified by sequence similarity YP_062507.1 identified by sequence similarity YP_062508.1 identified by sequence similarity YP_062509.1 identified by sequence similarity YP_062510.1 identified by sequence similarity YP_062511.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_062512.1 identified by sequence similarity YP_062513.1 identified by sequence similarity YP_062514.1 identified by sequence similarity YP_062515.1 identified by sequence similarity YP_062516.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_062517.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis YP_062518.1 identified by sequence similarity YP_062519.1 identified by sequence similarity YP_062520.1 identified by sequence similarity YP_062521.1 identified by sequence similarity YP_062522.1 identified by sequence similarity YP_062523.1 identified by sequence similarity YP_062524.1 identified by sequence similarity YP_062525.1 identified by sequence similarity YP_062526.1 identified by sequence similarity YP_062527.1 identified by sequence similarity YP_062528.1 identified by sequence similarity YP_062529.1 identified by sequence similarity YP_062530.1 identified by sequence similarity YP_062531.1 identified by sequence similarity YP_062532.1 identified by sequence similarity YP_062533.1 identified by sequence similarity YP_062535.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_062536.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_062537.1 identified by sequence similarity YP_062538.1 identified by sequence similarity YP_062539.1 identified by sequence similarity YP_062541.1 identified by sequence similarity YP_062543.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_062544.1 identified by sequence similarity YP_062545.1 identified by sequence similarity YP_062546.1 identified by sequence similarity YP_062547.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_062548.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_062550.1 identified by sequence similarity YP_062551.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_062552.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_062553.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_062554.1 identified by sequence similarity YP_062555.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_062557.1 identified by sequence similarity YP_062558.1 identified by sequence similarity YP_062559.1 identified by sequence similarity YP_062560.1 identified by sequence similarity YP_062562.1 identified by sequence similarity YP_062563.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_062564.1 identified by sequence similarity YP_062566.1 identified by sequence similarity YP_062567.1 identified by sequence similarity YP_062568.1 identified by sequence similarity YP_062569.1 identified by sequence similarity YP_062570.1 identified by sequence similarity YP_062572.1 identified by sequence similarity YP_062573.1 identified by sequence similarity YP_062574.1 identified by sequence similarity YP_062575.1 identified by sequence similarity YP_062576.1 identified by sequence similarity YP_062577.1 identified by sequence similarity YP_062578.1 identified by sequence similarity YP_062579.1 identified by sequence similarity YP_062580.1 identified by sequence similarity YP_062581.1 identified by sequence similarity YP_062582.1 identified by sequence similarity YP_062583.1 identified by sequence similarity YP_062585.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_062586.1 identified by sequence similarity YP_062587.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_062588.1 identified by sequence similarity YP_062589.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_062590.1 identified by sequence similarity YP_062591.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_062592.1 identified by sequence similarity YP_062593.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_062594.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_062595.1 identified by sequence similarity YP_062596.1 identified by sequence similarity YP_062597.1 identified by sequence similarity YP_062598.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_062600.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_062602.1 identified by sequence similarity YP_062603.1 identified by sequence similarity YP_062604.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_062605.1 identified by sequence similarity YP_062606.1 identified by sequence similarity YP_062607.1 identified by sequence similarity YP_062608.1 identified by sequence similarity YP_062609.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis YP_062610.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_062611.1 identified by sequence similarity YP_062612.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_062614.1 identified by sequence similarity YP_062615.1 identified by sequence similarity YP_062616.1 identified by sequence similarity YP_062617.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_062618.1 identified by sequence similarity YP_062619.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_062621.1 identified by sequence similarity YP_062622.1 identified by sequence similarity YP_062627.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_062628.1 Catalyzes the rate-limiting step in dNTP synthesis YP_062629.1 identified by sequence similarity YP_062630.1 identified by sequence similarity YP_062631.1 identified by sequence similarity YP_062632.1 identified by sequence similarity YP_062633.1 identified by sequence similarity YP_062634.1 identified by sequence similarity YP_062635.1 identified by sequence similarity YP_062636.1 identified by sequence similarity YP_062637.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_062638.1 identified by sequence similarity YP_062639.1 identified by sequence similarity YP_062640.1 identified by sequence similarity YP_062642.1 identified by sequence similarity YP_062643.1 identified by sequence similarity YP_062644.1 identified by sequence similarity YP_062645.1 identified by sequence similarity YP_062646.1 identified by sequence similarity YP_062647.1 identified by sequence similarity YP_062648.1 identified by sequence similarity YP_062649.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_062650.1 identified by sequence similarity YP_062651.1 identified by sequence similarity YP_062652.1 identified by sequence similarity YP_062653.1 identified by sequence similarity YP_062654.1 identified by sequence similarity YP_062655.1 identified by sequence similarity YP_062656.1 identified by sequence similarity YP_062657.1 identified by sequence similarity YP_062658.1 identified by sequence similarity YP_062659.1 identified by sequence similarity YP_062660.1 identified by sequence similarity YP_062661.1 identified by sequence similarity YP_062662.1 identified by sequence similarity YP_062663.1 identified by sequence similarity YP_062664.1 identified by sequence similarity YP_062665.1 identified by sequence similarity YP_062666.1 identified by sequence similarity YP_062667.1 identified by sequence similarity YP_062668.1 identified by sequence similarity YP_062669.1 identified by sequence similarity YP_062670.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_062671.1 identified by sequence similarity; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_062672.1 identified by sequence similarity YP_062674.1 identified by sequence similarity YP_062675.1 identified by sequence similarity YP_062676.1 identified by sequence similarity YP_062678.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_062679.1 identified by sequence similarity YP_062680.1 identified by sequence similarity YP_062681.1 identified by sequence similarity YP_062683.1 identified by sequence similarity YP_062684.1 identified by sequence similarity YP_062685.1 identified by sequence similarity YP_062686.1 identified by sequence similarity YP_062687.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_062688.1 identified by sequence similarity YP_062689.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins YP_062690.1 identified by sequence similarity YP_062691.1 identified by sequence similarity YP_062692.1 identified by sequence similarity YP_062693.1 identified by sequence similarity YP_062694.1 identified by sequence similarity YP_062695.1 identified by sequence similarity YP_062696.1 identified by sequence similarity YP_062697.1 identified by sequence similarity YP_062698.1 identified by sequence similarity YP_062699.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_062700.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_062701.1 identified by sequence similarity YP_062702.1 identified by sequence similarity YP_062704.1 identified by sequence similarity YP_062708.1 identified by sequence similarity YP_062709.1 identified by sequence similarity YP_062710.1 identified by sequence similarity YP_062711.1 identified by sequence similarity YP_062712.1 identified by sequence similarity YP_062713.1 identified by sequence similarity YP_062714.1 identified by sequence similarity YP_062717.1 identified by sequence similarity YP_062718.1 identified by sequence similarity YP_062720.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_062721.1 identified by sequence similarity YP_062722.1 identified by sequence similarity YP_062723.1 identified by sequence similarity YP_062724.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_062725.1 identified by sequence similarity YP_062728.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_062729.1 identified by sequence similarity YP_062730.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_062731.1 identified by sequence similarity YP_062733.1 identified by sequence similarity YP_062734.1 identified by sequence similarity YP_062736.1 identified by sequence similarity YP_062737.1 identified by sequence similarity YP_062738.1 identified by sequence similarity YP_062739.1 identified by sequence similarity YP_062740.1 identified by sequence similarity YP_062741.1 identified by sequence similarity YP_062742.1 identified by sequence similarity YP_062743.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_062744.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth YP_062745.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_062746.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_062747.1 identified by sequence similarity YP_062748.1 identified by sequence similarity YP_062749.1 identified by sequence similarity YP_062750.1 identified by sequence similarity YP_062751.1 identified by sequence similarity YP_062752.1 identified by sequence similarity YP_062754.1 identified by sequence similarity YP_062755.1 identified by sequence similarity YP_062756.1 identified by sequence similarity YP_062757.1 identified by sequence similarity YP_062758.1 identified by sequence similarity YP_062759.1 identified by sequence similarity YP_062760.1 identified by sequence similarity YP_062761.1 identified by sequence similarity YP_062763.1 identified by sequence similarity YP_062764.1 identified by sequence similarity YP_062765.1 identified by sequence similarity YP_062766.1 identified by sequence similarity YP_062771.1 identified by sequence similarity YP_062773.1 identified by sequence similarity YP_062774.1 Converts isocitrate to alpha ketoglutarate YP_062775.1 identified by sequence similarity YP_062776.1 identified by sequence similarity YP_062779.1 identified by sequence similarity YP_062780.1 identified by sequence similarity YP_062781.1 identified by sequence similarity YP_062782.1 identified by sequence similarity YP_062783.1 identified by sequence similarity YP_062784.1 identified by sequence similarity YP_062785.1 identified by sequence similarity YP_062786.1 identified by sequence similarity YP_062787.1 involved in de novo purine biosynthesis YP_062788.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_062789.1 identified by sequence similarity YP_062790.1 identified by sequence similarity YP_062791.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_062792.1 catalyzes the interconversion of succinyl-CoA and succinate YP_062793.1 identified by sequence similarity YP_062794.1 identified by sequence similarity YP_062795.1 identified by sequence similarity YP_062797.1 identified by sequence similarity YP_062798.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_062799.1 identified by sequence similarity YP_062800.1 identified by sequence similarity YP_062801.1 identified by sequence similarity YP_062802.1 identified by sequence similarity YP_062803.1 identified by sequence similarity YP_062804.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_062805.1 identified by sequence similarity YP_062806.1 identified by sequence similarity YP_062808.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_062809.1 identified by sequence similarity YP_062810.1 identified by sequence similarity YP_062811.1 identified by sequence similarity YP_062812.1 identified by sequence similarity YP_062813.1 identified by sequence similarity YP_062814.1 identified by sequence similarity YP_062815.1 identified by sequence similarity YP_062816.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_062817.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_062818.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_062819.1 identified by sequence similarity YP_062820.1 identified by sequence similarity YP_062821.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_062822.1 forms a direct contact with the tRNA during translation YP_062823.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_062824.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_062825.1 identified by sequence similarity YP_062827.1 is a component of the macrolide binding site in the peptidyl transferase center YP_062828.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_062829.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_062830.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_062831.1 identified by sequence similarity YP_062832.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_062833.1 identified by sequence similarity YP_062834.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_062835.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_062836.1 late assembly protein YP_062837.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_062838.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_062839.1 binds 5S rRNA along with protein L5 and L25 YP_062840.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_062841.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_062842.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_062843.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_062844.1 identified by sequence similarity YP_062845.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_062846.1 identified by sequence similarity YP_062847.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_062848.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_062849.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_062850.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_062851.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_062852.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_062853.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_062854.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_062855.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_062856.1 identified by sequence similarity YP_062857.1 identified by sequence similarity YP_062858.1 identified by sequence similarity YP_062859.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_062860.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_062861.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_062862.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_062865.1 identified by sequence similarity YP_062871.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_062872.1 identified by sequence similarity YP_062873.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_062874.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_062875.1 identified by sequence similarity YP_062876.1 identified by sequence similarity YP_062877.1 identified by sequence similarity YP_062881.1 identified by sequence similarity YP_062882.1 identified by sequence similarity YP_062883.1 identified by sequence similarity YP_062885.1 identified by sequence similarity YP_062886.1 identified by sequence similarity YP_062887.1 identified by sequence similarity YP_062888.1 identified by sequence similarity YP_062889.1 identified by sequence similarity YP_062890.1 identified by sequence similarity YP_062891.1 identified by sequence similarity YP_062892.1 identified by sequence similarity YP_062893.1 identified by sequence similarity YP_062894.1 identified by sequence similarity YP_062895.1 identified by sequence similarity YP_062896.1 identified by sequence similarity YP_062897.1 identified by sequence similarity YP_062898.1 identified by sequence similarity YP_062899.1 identified by sequence similarity YP_062901.1 identified by sequence similarity YP_062902.1 identified by sequence similarity YP_062903.1 identified by sequence similarity YP_062904.1 identified by sequence similarity YP_062905.1 identified by sequence similarity YP_062907.1 identified by sequence similarity YP_062911.1 identified by sequence similarity YP_062912.1 identified by sequence similarity YP_062915.1 identified by sequence similarity YP_062916.1 identified by sequence similarity YP_062917.1 identified by sequence similarity YP_062919.1 identified by sequence similarity YP_062920.1 identified by sequence similarity YP_062923.1 identified by sequence similarity YP_062924.1 identified by sequence similarity YP_062925.1 identified by sequence similarity YP_062926.1 identified by sequence similarity YP_062928.1 identified by sequence similarity YP_062931.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_062932.1 identified by sequence similarity YP_062933.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis YP_062934.1 identified by sequence similarity YP_062936.1 identified by sequence similarity YP_062938.1 identified by sequence similarity YP_062939.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_062940.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_062941.1 identified by sequence similarity YP_062942.1 identified by sequence similarity YP_062943.1 identified by sequence similarity YP_062944.1 identified by sequence similarity YP_062945.1 identified by sequence similarity YP_062946.1 identified by sequence similarity YP_062947.1 identified by sequence similarity YP_062948.1 identified by sequence similarity YP_062949.1 identified by sequence similarity YP_062950.1 identified by sequence similarity YP_062951.1 identified by sequence similarity YP_062952.1 identified by sequence similarity YP_062953.1 identified by sequence similarity YP_062954.1 identified by sequence similarity YP_062956.1 identified by sequence similarity YP_062957.1 identified by sequence similarity YP_062958.1 identified by sequence similarity YP_062959.1 identified by sequence similarity YP_062961.1 identified by sequence similarity YP_062962.1 identified by sequence similarity YP_062963.1 identified by sequence similarity YP_062965.1 identified by sequence similarity YP_062966.1 identified by sequence similarity YP_062969.1 identified by sequence similarity YP_062970.1 identified by sequence similarity YP_062972.1 identified by sequence similarity YP_062973.1 identified by sequence similarity YP_062974.1 identified by sequence similarity YP_062975.1 identified by sequence similarity YP_062976.1 identified by sequence similarity YP_062977.1 identified by sequence similarity YP_062978.1 identified by sequence similarity YP_062979.1 identified by sequence similarity YP_062980.1 identified by sequence similarity YP_062981.1 identified by sequence similarity YP_062982.1 identified by sequence similarity YP_062983.1 identified by sequence similarity YP_062984.1 identified by sequence similarity YP_062985.1 identified by sequence similarity YP_062986.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_062987.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_062988.1 identified by sequence similarity YP_062990.1 identified by sequence similarity YP_062991.1 identified by sequence similarity YP_062993.1 identified by sequence similarity YP_062994.1 identified by sequence similarity YP_062995.1 identified by sequence similarity YP_062996.1 identified by sequence similarity YP_062998.1 identified by sequence similarity YP_062999.1 identified by sequence similarity YP_063001.1 identified by sequence similarity YP_063002.1 identified by sequence similarity YP_063003.1 identified by sequence similarity YP_063004.1 identified by sequence similarity YP_063005.1 identified by sequence similarity YP_063006.1 identified by sequence similarity YP_063007.1 identified by sequence similarity YP_063010.1 identified by sequence similarity YP_063011.1 identified by sequence similarity YP_063012.1 identified by sequence similarity YP_063013.1 identified by sequence similarity YP_063015.1 identified by sequence similarity YP_063016.1 identified by sequence similarity YP_063017.1 identified by sequence similarity YP_063018.1 identified by sequence similarity YP_063019.1 identified by sequence similarity YP_063020.1 identified by sequence similarity YP_063021.1 identified by sequence similarity YP_063023.1 identified by sequence similarity YP_063024.1 identified by sequence similarity YP_063025.1 identified by sequence similarity YP_063027.1 identified by sequence similarity YP_063028.1 identified by sequence similarity YP_063029.1 identified by sequence similarity YP_063030.1 identified by sequence similarity YP_063031.1 identified by sequence similarity YP_063032.1 identified by sequence similarity YP_063033.1 identified by sequence similarity YP_063034.1 identified by sequence similarity YP_063036.1 identified by sequence similarity YP_063037.1 identified by sequence similarity YP_063038.1 identified by sequence similarity YP_063039.1 identified by sequence similarity YP_063040.1 identified by sequence similarity YP_063041.1 identified by sequence similarity YP_063042.1 identified by sequence similarity YP_063043.1 identified by sequence similarity YP_063044.1 identified by sequence similarity YP_063045.1 identified by sequence similarity YP_063046.1 identified by sequence similarity YP_063047.1 identified by sequence similarity YP_063048.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_063049.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_063051.1 identified by sequence similarity YP_063052.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_063053.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_063054.1 identified by sequence similarity YP_063055.1 identified by sequence similarity YP_063056.1 identified by sequence similarity YP_063058.1 identified by sequence similarity YP_063061.1 identified by sequence similarity YP_063062.1 identified by sequence similarity YP_063063.1 identified by sequence similarity YP_063064.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_063066.1 identified by sequence similarity YP_063068.1 identified by sequence similarity YP_063069.1 identified by sequence similarity YP_063070.1 identified by sequence similarity YP_063071.1 identified by sequence similarity YP_063073.1 identified by sequence similarity YP_063075.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_063076.1 identified by sequence similarity YP_063078.1 identified by sequence similarity YP_063079.1 identified by sequence similarity YP_063080.1 identified by sequence similarity YP_063082.1 identified by sequence similarity YP_063084.1 catalyzes the interconversion of chorismate to prephenate YP_063085.1 identified by sequence similarity YP_063086.1 identified by sequence similarity YP_063087.1 identified by sequence similarity YP_063088.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_063089.1 identified by sequence similarity YP_063090.1 identified by sequence similarity YP_063091.1 identified by sequence similarity YP_063092.1 identified by sequence similarity YP_063093.1 identified by sequence similarity YP_063094.1 identified by sequence similarity YP_063095.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_063096.1 identified by sequence similarity YP_063098.1 identified by sequence similarity YP_063100.1 identified by sequence similarity YP_063101.1 identified by sequence similarity YP_063102.1 identified by sequence similarity YP_063104.1 identified by sequence similarity YP_063105.1 identified by sequence similarity YP_063106.1 identified by sequence similarity YP_063107.1 identified by sequence similarity YP_063108.1 identified by sequence similarity YP_063109.1 identified by sequence similarity YP_063111.1 identified by sequence similarity YP_063112.1 identified by sequence similarity YP_063113.1 identified by sequence similarity YP_063114.1 identified by sequence similarity YP_063116.1 identified by sequence similarity YP_063117.1 identified by sequence similarity YP_063118.1 identified by sequence similarity YP_063119.1 identified by sequence similarity YP_063120.1 identified by sequence similarity YP_063121.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_063123.1 identified by sequence similarity YP_063124.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_063125.1 identified by sequence similarity YP_063126.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_063129.1 identified by sequence similarity YP_063130.1 identified by sequence similarity YP_063132.1 identified by sequence similarity YP_063133.1 identified by sequence similarity YP_063134.1 identified by sequence similarity YP_063142.1 identified by sequence similarity YP_063144.1 identified by sequence similarity YP_063145.1 identified by sequence similarity YP_063146.1 identified by sequence similarity YP_063150.1 identified by sequence similarity YP_063155.1 identified by sequence similarity YP_063156.1 identified by sequence similarity YP_063157.1 identified by sequence similarity YP_063158.1 identified by sequence similarity YP_063160.1 identified by sequence similarity YP_063162.1 identified by sequence similarity YP_063163.1 identified by sequence similarity YP_063165.1 identified by sequence similarity YP_063166.1 identified by sequence similarity YP_063170.1 identified by sequence similarity YP_063171.1 identified by sequence similarity YP_063172.1 identified by sequence similarity YP_063173.1 identified by sequence similarity YP_063176.1 identified by sequence similarity YP_063177.1 identified by sequence similarity YP_063178.1 identified by sequence similarity YP_063179.1 identified by sequence similarity YP_063181.1 identified by sequence similarity YP_063182.1 identified by sequence similarity YP_063183.1 identified by sequence similarity YP_063184.1 identified by sequence similarity YP_063185.1 identified by sequence similarity YP_063186.1 identified by sequence similarity YP_063187.1 identified by sequence similarity YP_063192.1 identified by sequence similarity YP_063193.1 identified by sequence similarity YP_063199.1 identified by sequence similarity YP_063203.1 identified by sequence similarity YP_063204.1 identified by sequence similarity YP_063205.1 identified by sequence similarity YP_063206.1 identified by sequence similarity YP_063209.1 identified by sequence similarity YP_063210.1 identified by sequence similarity YP_063211.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_063212.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_063213.1 required for 70S ribosome assembly YP_063214.1 identified by sequence similarity YP_063215.1 identified by sequence similarity YP_063216.1 identified by sequence similarity YP_063217.1 identified by sequence similarity YP_063218.1 identified by sequence similarity YP_063219.1 identified by sequence similarity YP_063220.1 identified by sequence similarity YP_063221.1 identified by sequence similarity YP_063222.1 identified by sequence similarity YP_063223.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_063225.1 identified by sequence similarity YP_063226.1 identified by sequence similarity YP_063227.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_063228.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_063229.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_063230.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_063231.1 identified by sequence similarity; tRNA nucleotidyltransferase YP_063232.1 identified by sequence similarity YP_063233.1 identified by sequence similarity YP_063234.1 identified by sequence similarity YP_063235.1 identified by sequence similarity YP_063236.1 identified by sequence similarity YP_063237.1 identified by sequence similarity YP_063238.1 identified by sequence similarity YP_063239.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_063240.1 identified by sequence similarity YP_063241.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_063242.1 identified by sequence similarity YP_063243.1 in Escherichia coli transcription of this gene is enhanced by polyamines