-- dump date 20140619_130711 -- class Genbank::misc_feature -- table misc_feature_note -- id note 281090000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 281090000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090000003 Walker A motif; other site 281090000004 ATP binding site [chemical binding]; other site 281090000005 Walker B motif; other site 281090000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 281090000007 arginine finger; other site 281090000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 281090000009 DnaA box-binding interface [nucleotide binding]; other site 281090000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 281090000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 281090000012 putative DNA binding surface [nucleotide binding]; other site 281090000013 dimer interface [polypeptide binding]; other site 281090000014 beta-clamp/clamp loader binding surface; other site 281090000015 beta-clamp/translesion DNA polymerase binding surface; other site 281090000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 281090000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 281090000018 recombination protein F; Reviewed; Region: recF; PRK00064 281090000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 281090000020 Walker A/P-loop; other site 281090000021 ATP binding site [chemical binding]; other site 281090000022 Q-loop/lid; other site 281090000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090000024 ABC transporter signature motif; other site 281090000025 Walker B; other site 281090000026 D-loop; other site 281090000027 H-loop/switch region; other site 281090000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 281090000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 281090000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090000031 Mg2+ binding site [ion binding]; other site 281090000032 G-X-G motif; other site 281090000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 281090000034 anchoring element; other site 281090000035 dimer interface [polypeptide binding]; other site 281090000036 ATP binding site [chemical binding]; other site 281090000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 281090000038 active site 281090000039 putative metal-binding site [ion binding]; other site 281090000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 281090000041 DNA gyrase subunit A; Validated; Region: PRK05560 281090000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 281090000043 CAP-like domain; other site 281090000044 active site 281090000045 primary dimer interface [polypeptide binding]; other site 281090000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281090000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281090000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281090000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281090000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 281090000051 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 281090000052 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 281090000053 putative DNA binding site [nucleotide binding]; other site 281090000054 catalytic residue [active] 281090000055 putative H2TH interface [polypeptide binding]; other site 281090000056 putative catalytic residues [active] 281090000057 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 281090000058 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 281090000059 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 281090000060 nudix motif; other site 281090000061 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 281090000062 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 281090000063 active site 281090000064 Rhomboid family; Region: Rhomboid; cl11446 281090000065 Rhomboid family; Region: Rhomboid; pfam01694 281090000066 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 281090000067 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 281090000068 active site 281090000069 catalytic site [active] 281090000070 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 281090000071 Glutamine amidotransferase class-I; Region: GATase; pfam00117 281090000072 glutamine binding [chemical binding]; other site 281090000073 catalytic triad [active] 281090000074 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 281090000075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281090000076 active site 281090000077 ATP binding site [chemical binding]; other site 281090000078 substrate binding site [chemical binding]; other site 281090000079 activation loop (A-loop); other site 281090000080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090000081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090000082 PASTA domain; Region: PASTA; smart00740 281090000083 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281090000084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 281090000085 active site 281090000086 ATP binding site [chemical binding]; other site 281090000087 substrate binding site [chemical binding]; other site 281090000088 activation loop (A-loop); other site 281090000089 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281090000090 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281090000091 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 281090000092 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 281090000093 active site 281090000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 281090000095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 281090000096 phosphopeptide binding site; other site 281090000097 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 281090000098 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 281090000099 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 281090000100 phosphopeptide binding site; other site 281090000101 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 281090000102 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 281090000103 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 281090000104 shikimate binding site; other site 281090000105 NAD(P) binding site [chemical binding]; other site 281090000106 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 281090000107 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281090000108 Walker A/P-loop; other site 281090000109 ATP binding site [chemical binding]; other site 281090000110 Q-loop/lid; other site 281090000111 ABC transporter signature motif; other site 281090000112 Walker B; other site 281090000113 D-loop; other site 281090000114 H-loop/switch region; other site 281090000115 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281090000116 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281090000117 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281090000118 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 281090000119 TM-ABC transporter signature motif; other site 281090000120 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 281090000121 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 281090000122 putative ligand binding site [chemical binding]; other site 281090000123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281090000124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090000125 non-specific DNA binding site [nucleotide binding]; other site 281090000126 salt bridge; other site 281090000127 sequence-specific DNA binding site [nucleotide binding]; other site 281090000128 Domain of unknown function (DUF955); Region: DUF955; cl01076 281090000129 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 281090000130 active site 281090000131 catalytic triad [active] 281090000132 oxyanion hole [active] 281090000133 Protein of unknown function (DUF2746); Region: DUF2746; pfam10874 281090000134 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 281090000135 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090000136 active site 281090000137 Homeodomain-like domain; Region: HTH_23; cl17451 281090000138 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 281090000139 nudix motif; other site 281090000140 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090000141 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281090000142 DNA binding site [nucleotide binding] 281090000143 Int/Topo IB signature motif; other site 281090000144 active site 281090000145 catalytic residues [active] 281090000146 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281090000147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090000148 DNA-binding site [nucleotide binding]; DNA binding site 281090000149 Transcriptional regulators [Transcription]; Region: FadR; COG2186 281090000150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090000151 DNA-binding site [nucleotide binding]; DNA binding site 281090000152 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 281090000153 CopC domain; Region: CopC; cl01012 281090000154 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 281090000155 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090000156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281090000157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090000158 dimer interface [polypeptide binding]; other site 281090000159 conserved gate region; other site 281090000160 putative PBP binding loops; other site 281090000161 ABC-ATPase subunit interface; other site 281090000162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281090000163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090000164 dimer interface [polypeptide binding]; other site 281090000165 conserved gate region; other site 281090000166 putative PBP binding loops; other site 281090000167 ABC-ATPase subunit interface; other site 281090000168 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090000169 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090000170 Integrase core domain; Region: rve; pfam00665 281090000171 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 281090000172 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 281090000173 substrate binding site [chemical binding]; other site 281090000174 ATP binding site [chemical binding]; other site 281090000175 Transcriptional regulator [Transcription]; Region: IclR; COG1414 281090000176 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 281090000177 Bacterial transcriptional regulator; Region: IclR; pfam01614 281090000178 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 281090000179 homotrimer interaction site [polypeptide binding]; other site 281090000180 putative active site [active] 281090000181 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 281090000182 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 281090000183 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 281090000184 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 281090000185 CrcB-like protein; Region: CRCB; pfam02537 281090000186 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 281090000187 Ligand Binding Site [chemical binding]; other site 281090000188 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 281090000189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281090000190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090000191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090000192 active site 281090000193 phosphorylation site [posttranslational modification] 281090000194 intermolecular recognition site; other site 281090000195 dimerization interface [polypeptide binding]; other site 281090000196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090000197 DNA binding residues [nucleotide binding] 281090000198 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 281090000199 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 281090000200 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 281090000201 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 281090000202 active site 281090000203 phosphorylation site [posttranslational modification] 281090000204 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 281090000205 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 281090000206 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 281090000207 active site 281090000208 P-loop; other site 281090000209 phosphorylation site [posttranslational modification] 281090000210 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 281090000211 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 281090000212 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 281090000213 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 281090000214 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 281090000215 dimerization domain swap beta strand [polypeptide binding]; other site 281090000216 regulatory protein interface [polypeptide binding]; other site 281090000217 active site 281090000218 regulatory phosphorylation site [posttranslational modification]; other site 281090000219 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 281090000220 active site 281090000221 P-loop; other site 281090000222 phosphorylation site [posttranslational modification] 281090000223 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 281090000224 HTH domain; Region: HTH_11; cl17392 281090000225 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 281090000226 PRD domain; Region: PRD; pfam00874 281090000227 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 281090000228 active site 281090000229 P-loop; other site 281090000230 phosphorylation site [posttranslational modification] 281090000231 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 281090000232 active site 281090000233 phosphorylation site [posttranslational modification] 281090000234 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 281090000235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090000236 motif II; other site 281090000237 hypothetical protein; Provisional; Region: PRK03298 281090000238 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 281090000239 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 281090000240 putative efflux protein, MATE family; Region: matE; TIGR00797 281090000241 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 281090000242 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 281090000243 active site 281090000244 Zn binding site [ion binding]; other site 281090000245 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 281090000246 glycyl-tRNA synthetase; Provisional; Region: PRK04173 281090000247 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 281090000248 motif 1; other site 281090000249 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 281090000250 active site 281090000251 motif 2; other site 281090000252 motif 3; other site 281090000253 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 281090000254 anticodon binding site; other site 281090000255 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 281090000256 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 281090000257 NAD(P) binding pocket [chemical binding]; other site 281090000258 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 281090000259 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 281090000260 substrate binding site [chemical binding]; other site 281090000261 active site 281090000262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281090000263 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 281090000264 ferrochelatase; Reviewed; Region: hemH; PRK00035 281090000265 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 281090000266 C-terminal domain interface [polypeptide binding]; other site 281090000267 active site 281090000268 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 281090000269 active site 281090000270 N-terminal domain interface [polypeptide binding]; other site 281090000271 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 281090000272 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 281090000273 domain interfaces; other site 281090000274 active site 281090000275 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 281090000276 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 281090000277 active site 281090000278 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 281090000279 dimer interface [polypeptide binding]; other site 281090000280 active site 281090000281 Schiff base residues; other site 281090000282 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281090000283 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 281090000284 inhibitor-cofactor binding pocket; inhibition site 281090000285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090000286 catalytic residue [active] 281090000287 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 281090000288 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 281090000289 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 281090000290 NADP binding site [chemical binding]; other site 281090000291 dimer interface [polypeptide binding]; other site 281090000292 LssY C-terminus; Region: LssY_C; pfam14067 281090000293 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 281090000294 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 281090000295 Ligand binding site; other site 281090000296 Putative Catalytic site; other site 281090000297 DXD motif; other site 281090000298 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 281090000299 substrate binding site [chemical binding]; other site 281090000300 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 281090000301 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 281090000302 tetramer interface [polypeptide binding]; other site 281090000303 active site 281090000304 Mg2+/Mn2+ binding site [ion binding]; other site 281090000305 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 281090000306 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 281090000307 Dimer interface [polypeptide binding]; other site 281090000308 anticodon binding site; other site 281090000309 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 281090000310 motif 1; other site 281090000311 dimer interface [polypeptide binding]; other site 281090000312 active site 281090000313 motif 2; other site 281090000314 motif 3; other site 281090000315 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281090000316 catalytic core [active] 281090000317 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 281090000318 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 281090000319 catalytic residues [active] 281090000320 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 281090000321 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 281090000322 ResB-like family; Region: ResB; pfam05140 281090000323 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 281090000324 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 281090000325 transcription termination factor Rho; Provisional; Region: PRK12678 281090000326 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 281090000327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090000328 active site 281090000329 motif I; other site 281090000330 motif II; other site 281090000331 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 281090000332 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 281090000333 O-succinylbenzoate synthase; Provisional; Region: PRK05105 281090000334 active site 281090000335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281090000336 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 281090000337 substrate binding site [chemical binding]; other site 281090000338 oxyanion hole (OAH) forming residues; other site 281090000339 trimer interface [polypeptide binding]; other site 281090000340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281090000341 acyl-activating enzyme (AAE) consensus motif; other site 281090000342 AMP binding site [chemical binding]; other site 281090000343 active site 281090000344 CoA binding site [chemical binding]; other site 281090000345 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 281090000346 UbiA prenyltransferase family; Region: UbiA; pfam01040 281090000347 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 281090000348 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 281090000349 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 281090000350 dimer interface [polypeptide binding]; other site 281090000351 tetramer interface [polypeptide binding]; other site 281090000352 PYR/PP interface [polypeptide binding]; other site 281090000353 TPP binding site [chemical binding]; other site 281090000354 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 281090000355 TPP-binding site; other site 281090000356 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090000357 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 281090000358 DNA methylase; Region: N6_N4_Mtase; pfam01555 281090000359 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 281090000360 active site 281090000361 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 281090000362 Homeodomain-like domain; Region: HTH_23; cl17451 281090000363 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090000364 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281090000365 nucleotide binding site [chemical binding]; other site 281090000366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090000367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090000368 DNA binding site [nucleotide binding] 281090000369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090000370 active site 281090000371 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 281090000372 nucleoside/Zn binding site; other site 281090000373 dimer interface [polypeptide binding]; other site 281090000374 catalytic motif [active] 281090000375 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 281090000376 Cation efflux family; Region: Cation_efflux; pfam01545 281090000377 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 281090000378 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 281090000379 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 281090000380 TrkA-N domain; Region: TrkA_N; pfam02254 281090000381 TrkA-C domain; Region: TrkA_C; pfam02080 281090000382 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 281090000383 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 281090000384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090000385 dimerization interface [polypeptide binding]; other site 281090000386 putative DNA binding site [nucleotide binding]; other site 281090000387 putative Zn2+ binding site [ion binding]; other site 281090000388 DNA binding domain, excisionase family; Region: excise; TIGR01764 281090000389 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 281090000390 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 281090000391 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281090000392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090000393 DNA-binding site [nucleotide binding]; DNA binding site 281090000394 FCD domain; Region: FCD; pfam07729 281090000395 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281090000396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090000397 DNA-binding site [nucleotide binding]; DNA binding site 281090000398 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 281090000399 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 281090000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090000401 S-adenosylmethionine binding site [chemical binding]; other site 281090000402 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 281090000403 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 281090000404 substrate binding pocket [chemical binding]; other site 281090000405 chain length determination region; other site 281090000406 substrate-Mg2+ binding site; other site 281090000407 catalytic residues [active] 281090000408 aspartate-rich region 1; other site 281090000409 active site lid residues [active] 281090000410 aspartate-rich region 2; other site 281090000411 ferredoxin-NADP+ reductase; Region: PLN02852 281090000412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 281090000413 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 281090000414 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 281090000415 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 281090000416 active site 281090000417 catalytic triad [active] 281090000418 oxyanion hole [active] 281090000419 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 281090000420 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 281090000421 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 281090000422 active site 281090000423 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 281090000424 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 281090000425 Ligand binding site; other site 281090000426 Putative Catalytic site; other site 281090000427 DXD motif; other site 281090000428 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 281090000429 Ligand binding site; other site 281090000430 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 281090000431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090000432 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281090000433 MarR family; Region: MarR_2; pfam12802 281090000434 MarR family; Region: MarR_2; cl17246 281090000435 Transglycosylase; Region: Transgly; pfam00912 281090000436 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281090000437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 281090000438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281090000439 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 281090000440 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 281090000441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281090000442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281090000443 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 281090000444 Walker A/P-loop; other site 281090000445 ATP binding site [chemical binding]; other site 281090000446 Q-loop/lid; other site 281090000447 ABC transporter signature motif; other site 281090000448 Walker B; other site 281090000449 D-loop; other site 281090000450 H-loop/switch region; other site 281090000451 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281090000452 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281090000453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090000454 Walker A/P-loop; other site 281090000455 ATP binding site [chemical binding]; other site 281090000456 Q-loop/lid; other site 281090000457 ABC transporter signature motif; other site 281090000458 Walker B; other site 281090000459 D-loop; other site 281090000460 H-loop/switch region; other site 281090000461 RibD C-terminal domain; Region: RibD_C; cl17279 281090000462 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 281090000463 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 281090000464 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 281090000465 active site 281090000466 catalytic site [active] 281090000467 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 281090000468 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 281090000469 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 281090000470 catalytic site [active] 281090000471 active site 281090000472 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 281090000473 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 281090000474 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 281090000475 active site 281090000476 catalytic site [active] 281090000477 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 281090000478 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 281090000479 active site 281090000480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090000481 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 281090000482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090000483 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 281090000484 active site 281090000485 motif I; other site 281090000486 motif II; other site 281090000487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090000488 seryl-tRNA synthetase; Provisional; Region: PRK05431 281090000489 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 281090000490 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 281090000491 dimer interface [polypeptide binding]; other site 281090000492 active site 281090000493 motif 1; other site 281090000494 motif 2; other site 281090000495 motif 3; other site 281090000496 Prephenate dehydratase; Region: PDT; pfam00800 281090000497 prephenate dehydratase; Provisional; Region: PRK11898 281090000498 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 281090000499 putative L-Phe binding site [chemical binding]; other site 281090000500 phosphoglucomutase; Validated; Region: PRK07564 281090000501 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 281090000502 active site 281090000503 substrate binding site [chemical binding]; other site 281090000504 metal binding site [ion binding]; metal-binding site 281090000505 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 281090000506 Putative amidase domain; Region: Amidase_6; pfam12671 281090000507 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 281090000508 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090000509 active site 281090000510 Protein of unknown function (DUF2746); Region: DUF2746; pfam10874 281090000511 Domain of unknown function (DUF955); Region: DUF955; cl01076 281090000512 DNA methylase; Region: N6_N4_Mtase; cl17433 281090000513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281090000514 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 281090000515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281090000516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281090000517 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 281090000518 putative dimerization interface [polypeptide binding]; other site 281090000519 Proline dehydrogenase; Region: Pro_dh; cl03282 281090000520 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 281090000521 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 281090000522 NAD(P) binding site [chemical binding]; other site 281090000523 catalytic residues [active] 281090000524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090000525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 281090000526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090000527 dimer interface [polypeptide binding]; other site 281090000528 phosphorylation site [posttranslational modification] 281090000529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090000530 ATP binding site [chemical binding]; other site 281090000531 Mg2+ binding site [ion binding]; other site 281090000532 G-X-G motif; other site 281090000533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090000534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090000535 active site 281090000536 phosphorylation site [posttranslational modification] 281090000537 intermolecular recognition site; other site 281090000538 dimerization interface [polypeptide binding]; other site 281090000539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090000540 DNA binding site [nucleotide binding] 281090000541 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 281090000542 POT family; Region: PTR2; cl17359 281090000543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090000544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 281090000545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090000546 dimer interface [polypeptide binding]; other site 281090000547 conserved gate region; other site 281090000548 putative PBP binding loops; other site 281090000549 ABC-ATPase subunit interface; other site 281090000550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281090000551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090000552 dimer interface [polypeptide binding]; other site 281090000553 conserved gate region; other site 281090000554 putative PBP binding loops; other site 281090000555 ABC-ATPase subunit interface; other site 281090000556 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 281090000557 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 281090000558 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 281090000559 putative active site [active] 281090000560 H+ Antiporter protein; Region: 2A0121; TIGR00900 281090000561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090000562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281090000563 MarR family; Region: MarR_2; pfam12802 281090000564 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 281090000565 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 281090000566 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 281090000567 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 281090000568 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 281090000569 heme binding pocket [chemical binding]; other site 281090000570 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 281090000571 metal binding site 2 [ion binding]; metal-binding site 281090000572 putative DNA binding helix; other site 281090000573 metal binding site 1 [ion binding]; metal-binding site 281090000574 dimer interface [polypeptide binding]; other site 281090000575 structural Zn2+ binding site [ion binding]; other site 281090000576 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 281090000577 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 281090000578 active site 281090000579 catalytic site [active] 281090000580 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 281090000581 active site 281090000582 catalytic site [active] 281090000583 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 281090000584 FAD binding domain; Region: FAD_binding_4; pfam01565 281090000585 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 281090000586 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 281090000587 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 281090000588 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 281090000589 putative homodimer interface [polypeptide binding]; other site 281090000590 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 281090000591 heterodimer interface [polypeptide binding]; other site 281090000592 homodimer interface [polypeptide binding]; other site 281090000593 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 281090000594 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 281090000595 23S rRNA interface [nucleotide binding]; other site 281090000596 L7/L12 interface [polypeptide binding]; other site 281090000597 putative thiostrepton binding site; other site 281090000598 L25 interface [polypeptide binding]; other site 281090000599 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 281090000600 mRNA/rRNA interface [nucleotide binding]; other site 281090000601 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 281090000602 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 281090000603 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 281090000604 putative NAD(P) binding site [chemical binding]; other site 281090000605 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 281090000606 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 281090000607 conserved cys residue [active] 281090000608 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281090000609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281090000610 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281090000611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 281090000612 dimerization interface [polypeptide binding]; other site 281090000613 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 281090000614 putative Zn2+ binding site [ion binding]; other site 281090000615 putative DNA binding site [nucleotide binding]; other site 281090000616 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090000617 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281090000618 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 281090000619 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281090000620 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281090000621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281090000622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281090000623 Walker A/P-loop; other site 281090000624 ATP binding site [chemical binding]; other site 281090000625 Q-loop/lid; other site 281090000626 ABC transporter signature motif; other site 281090000627 Walker B; other site 281090000628 D-loop; other site 281090000629 H-loop/switch region; other site 281090000630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281090000631 FtsX-like permease family; Region: FtsX; pfam02687 281090000632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090000633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090000634 active site 281090000635 phosphorylation site [posttranslational modification] 281090000636 intermolecular recognition site; other site 281090000637 dimerization interface [polypeptide binding]; other site 281090000638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090000639 DNA binding site [nucleotide binding] 281090000640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090000641 HAMP domain; Region: HAMP; pfam00672 281090000642 dimerization interface [polypeptide binding]; other site 281090000643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090000644 dimer interface [polypeptide binding]; other site 281090000645 phosphorylation site [posttranslational modification] 281090000646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090000647 ATP binding site [chemical binding]; other site 281090000648 Mg2+ binding site [ion binding]; other site 281090000649 G-X-G motif; other site 281090000650 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 281090000651 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 281090000652 23S rRNA interface [nucleotide binding]; other site 281090000653 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 281090000654 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 281090000655 core dimer interface [polypeptide binding]; other site 281090000656 peripheral dimer interface [polypeptide binding]; other site 281090000657 L10 interface [polypeptide binding]; other site 281090000658 L11 interface [polypeptide binding]; other site 281090000659 putative EF-Tu interaction site [polypeptide binding]; other site 281090000660 putative EF-G interaction site [polypeptide binding]; other site 281090000661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281090000662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281090000663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281090000664 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 281090000665 Walker A/P-loop; other site 281090000666 ATP binding site [chemical binding]; other site 281090000667 Q-loop/lid; other site 281090000668 ABC transporter signature motif; other site 281090000669 Walker B; other site 281090000670 D-loop; other site 281090000671 H-loop/switch region; other site 281090000672 Septum formation; Region: Septum_form; pfam13845 281090000673 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 281090000674 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 281090000675 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 281090000676 FeoA domain; Region: FeoA; pfam04023 281090000677 Acyltransferase family; Region: Acyl_transf_3; pfam01757 281090000678 cystathionine gamma-synthase; Provisional; Region: PRK07811 281090000679 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281090000680 homodimer interface [polypeptide binding]; other site 281090000681 substrate-cofactor binding pocket; other site 281090000682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090000683 catalytic residue [active] 281090000684 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 281090000685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281090000686 active site 281090000687 Predicted membrane protein [Function unknown]; Region: COG2246 281090000688 GtrA-like protein; Region: GtrA; pfam04138 281090000689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281090000690 D-xylulose kinase; Region: XylB; TIGR01312 281090000691 nucleotide binding site [chemical binding]; other site 281090000692 xylose isomerase; Provisional; Region: PRK12677 281090000693 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 281090000694 phosphate acetyltransferase; Reviewed; Region: PRK05632 281090000695 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 281090000696 DRTGG domain; Region: DRTGG; pfam07085 281090000697 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 281090000698 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 281090000699 propionate/acetate kinase; Provisional; Region: PRK12379 281090000700 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 281090000701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090000702 Walker A motif; other site 281090000703 ATP binding site [chemical binding]; other site 281090000704 Walker B motif; other site 281090000705 arginine finger; other site 281090000706 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 281090000707 recombination protein RecR; Reviewed; Region: recR; PRK00076 281090000708 RecR protein; Region: RecR; pfam02132 281090000709 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 281090000710 putative active site [active] 281090000711 putative metal-binding site [ion binding]; other site 281090000712 tetramer interface [polypeptide binding]; other site 281090000713 aspartate kinase; Reviewed; Region: PRK06635 281090000714 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 281090000715 putative nucleotide binding site [chemical binding]; other site 281090000716 putative catalytic residues [active] 281090000717 putative Mg ion binding site [ion binding]; other site 281090000718 putative aspartate binding site [chemical binding]; other site 281090000719 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 281090000720 putative allosteric regulatory site; other site 281090000721 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 281090000722 putative allosteric regulatory residue; other site 281090000723 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 281090000724 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 281090000725 malate:quinone oxidoreductase; Validated; Region: PRK05257 281090000726 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 281090000727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281090000728 Radical SAM superfamily; Region: Radical_SAM; pfam04055 281090000729 FeS/SAM binding site; other site 281090000730 thymidine kinase; Provisional; Region: PRK04296 281090000731 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 281090000732 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 281090000733 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 281090000734 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 281090000735 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 281090000736 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 281090000737 Fic family protein [Function unknown]; Region: COG3177 281090000738 Fic/DOC family; Region: Fic; pfam02661 281090000739 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090000740 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281090000741 DNA binding site [nucleotide binding] 281090000742 Int/Topo IB signature motif; other site 281090000743 active site 281090000744 catalytic residues [active] 281090000745 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 281090000746 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 281090000747 active site 281090000748 metal binding site [ion binding]; metal-binding site 281090000749 Transglycosylase; Region: Transgly; pfam00912 281090000750 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281090000751 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 281090000752 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090000753 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090000754 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 281090000755 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 281090000756 homotrimer interaction site [polypeptide binding]; other site 281090000757 putative active site [active] 281090000758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281090000759 Transposase; Region: HTH_Tnp_1; cl17663 281090000760 Transposase; Region: DEDD_Tnp_IS110; pfam01548 281090000761 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 281090000762 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 281090000763 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090000764 active site 281090000765 Phage-related protein [Function unknown]; Region: COG5412 281090000766 Phage-related protein [Function unknown]; Region: COG5412 281090000767 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 281090000768 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 281090000769 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 281090000770 Phage terminase large subunit; Region: Terminase_3; cl12054 281090000771 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 281090000772 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 281090000773 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 281090000774 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 281090000775 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 281090000776 active site 281090000777 metal binding site [ion binding]; metal-binding site 281090000778 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 281090000779 domain I; other site 281090000780 phosphate binding site [ion binding]; other site 281090000781 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 281090000782 domain II; other site 281090000783 domain III; other site 281090000784 nucleotide binding site [chemical binding]; other site 281090000785 DNA binding groove [nucleotide binding] 281090000786 catalytic site [active] 281090000787 domain IV; other site 281090000788 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 281090000789 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 281090000790 thymidylate kinase; Validated; Region: tmk; PRK00698 281090000791 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 281090000792 TMP-binding site; other site 281090000793 ATP-binding site [chemical binding]; other site 281090000794 DNA polymerase III subunit delta'; Validated; Region: PRK07940 281090000795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090000796 Walker A motif; other site 281090000797 ATP binding site [chemical binding]; other site 281090000798 Walker B motif; other site 281090000799 arginine finger; other site 281090000800 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 281090000801 TAP-like protein; Region: Abhydrolase_4; pfam08386 281090000802 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 281090000803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090000804 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 281090000805 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 281090000806 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 281090000807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090000808 NAD(P) binding site [chemical binding]; other site 281090000809 active site 281090000810 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 281090000811 phosphopeptide binding site; other site 281090000812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281090000813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090000814 non-specific DNA binding site [nucleotide binding]; other site 281090000815 salt bridge; other site 281090000816 sequence-specific DNA binding site [nucleotide binding]; other site 281090000817 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 281090000818 Domain of unknown function (DUF955); Region: DUF955; pfam06114 281090000819 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 281090000820 active site 281090000821 substrate-binding site [chemical binding]; other site 281090000822 metal-binding site [ion binding] 281090000823 GTP binding site [chemical binding]; other site 281090000824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281090000825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090000826 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 281090000827 Walker A/P-loop; other site 281090000828 ATP binding site [chemical binding]; other site 281090000829 Q-loop/lid; other site 281090000830 ABC transporter signature motif; other site 281090000831 Walker B; other site 281090000832 D-loop; other site 281090000833 H-loop/switch region; other site 281090000834 Sensors of blue-light using FAD; Region: BLUF; pfam04940 281090000835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090000836 non-specific DNA binding site [nucleotide binding]; other site 281090000837 salt bridge; other site 281090000838 sequence-specific DNA binding site [nucleotide binding]; other site 281090000839 Integrase core domain; Region: rve; pfam00665 281090000840 Integrase core domain; Region: rve_3; cl15866 281090000841 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090000842 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090000843 Integrase core domain; Region: rve; pfam00665 281090000844 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 281090000845 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 281090000846 homopentamer interface [polypeptide binding]; other site 281090000847 active site 281090000848 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 281090000849 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 281090000850 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 281090000851 dimerization interface [polypeptide binding]; other site 281090000852 active site 281090000853 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 281090000854 Lumazine binding domain; Region: Lum_binding; pfam00677 281090000855 Lumazine binding domain; Region: Lum_binding; pfam00677 281090000856 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 281090000857 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 281090000858 catalytic motif [active] 281090000859 Zn binding site [ion binding]; other site 281090000860 RibD C-terminal domain; Region: RibD_C; pfam01872 281090000861 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 281090000862 amphipathic channel; other site 281090000863 Asn-Pro-Ala signature motifs; other site 281090000864 glycerol kinase; Provisional; Region: glpK; PRK00047 281090000865 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 281090000866 N- and C-terminal domain interface [polypeptide binding]; other site 281090000867 active site 281090000868 MgATP binding site [chemical binding]; other site 281090000869 catalytic site [active] 281090000870 metal binding site [ion binding]; metal-binding site 281090000871 putative homotetramer interface [polypeptide binding]; other site 281090000872 glycerol binding site [chemical binding]; other site 281090000873 homodimer interface [polypeptide binding]; other site 281090000874 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281090000875 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 281090000876 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 281090000877 active site 281090000878 HIGH motif; other site 281090000879 dimer interface [polypeptide binding]; other site 281090000880 KMSKS motif; other site 281090000881 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 281090000882 putative active site [active] 281090000883 putative catalytic site [active] 281090000884 putative DNA binding site [nucleotide binding]; other site 281090000885 putative phosphate binding site [ion binding]; other site 281090000886 metal binding site A [ion binding]; metal-binding site 281090000887 putative AP binding site [nucleotide binding]; other site 281090000888 putative metal binding site B [ion binding]; other site 281090000889 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 281090000890 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 281090000891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 281090000892 catalytic loop [active] 281090000893 iron binding site [ion binding]; other site 281090000894 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 281090000895 L-aspartate oxidase; Provisional; Region: PRK06175 281090000896 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 281090000897 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 281090000898 putative Iron-sulfur protein interface [polypeptide binding]; other site 281090000899 putative proximal heme binding site [chemical binding]; other site 281090000900 putative SdhC-like subunit interface [polypeptide binding]; other site 281090000901 putative distal heme binding site [chemical binding]; other site 281090000902 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 281090000903 putative Iron-sulfur protein interface [polypeptide binding]; other site 281090000904 putative proximal heme binding site [chemical binding]; other site 281090000905 putative SdhD-like interface [polypeptide binding]; other site 281090000906 putative distal heme binding site [chemical binding]; other site 281090000907 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 281090000908 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 281090000909 Substrate binding site; other site 281090000910 Cupin domain; Region: Cupin_2; cl17218 281090000911 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 281090000912 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 281090000913 oligomer interface [polypeptide binding]; other site 281090000914 metal binding site [ion binding]; metal-binding site 281090000915 metal binding site [ion binding]; metal-binding site 281090000916 putative Cl binding site [ion binding]; other site 281090000917 hydrophobic gate; other site 281090000918 periplasmic entrance; other site 281090000919 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 281090000920 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 281090000921 ligand binding site [chemical binding]; other site 281090000922 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 281090000923 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281090000924 Walker A/P-loop; other site 281090000925 ATP binding site [chemical binding]; other site 281090000926 Q-loop/lid; other site 281090000927 ABC transporter signature motif; other site 281090000928 Walker B; other site 281090000929 D-loop; other site 281090000930 H-loop/switch region; other site 281090000931 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281090000932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 281090000933 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 281090000934 TM-ABC transporter signature motif; other site 281090000935 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 281090000936 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 281090000937 TM-ABC transporter signature motif; other site 281090000938 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 281090000939 active site 281090000940 catalytic motif [active] 281090000941 Zn binding site [ion binding]; other site 281090000942 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 281090000943 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 281090000944 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 281090000945 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 281090000946 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 281090000947 adenosine deaminase; Provisional; Region: PRK09358 281090000948 active site 281090000949 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 281090000950 active site 281090000951 phosphorylation site [posttranslational modification] 281090000952 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 281090000953 active site 281090000954 P-loop; other site 281090000955 phosphorylation site [posttranslational modification] 281090000956 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 281090000957 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 281090000958 active site 281090000959 substrate binding site [chemical binding]; other site 281090000960 metal binding site [ion binding]; metal-binding site 281090000961 purine nucleoside phosphorylase; Provisional; Region: PRK08202 281090000962 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 281090000963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 281090000964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281090000965 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 281090000966 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 281090000967 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281090000968 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 281090000969 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 281090000970 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 281090000971 carboxyltransferase (CT) interaction site; other site 281090000972 biotinylation site [posttranslational modification]; other site 281090000973 Maf-like protein; Region: Maf; pfam02545 281090000974 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 281090000975 active site 281090000976 dimer interface [polypeptide binding]; other site 281090000977 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 281090000978 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 281090000979 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 281090000980 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 281090000981 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 281090000982 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 281090000983 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 281090000984 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 281090000985 Predicted membrane protein [Function unknown]; Region: COG2246 281090000986 GtrA-like protein; Region: GtrA; pfam04138 281090000987 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 281090000988 ATP-grasp domain; Region: ATP-grasp; pfam02222 281090000989 AIR carboxylase; Region: AIRC; pfam00731 281090000990 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 281090000991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281090000992 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 281090000993 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 281090000994 NADP binding site [chemical binding]; other site 281090000995 active site 281090000996 putative substrate binding site [chemical binding]; other site 281090000997 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 281090000998 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 281090000999 NAD binding site [chemical binding]; other site 281090001000 substrate binding site [chemical binding]; other site 281090001001 homodimer interface [polypeptide binding]; other site 281090001002 active site 281090001003 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 281090001004 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 281090001005 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 281090001006 substrate binding site; other site 281090001007 tetramer interface; other site 281090001008 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 281090001009 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 281090001010 Probable Catalytic site; other site 281090001011 metal-binding site 281090001012 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 281090001013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281090001014 putative NAD(P) binding site [chemical binding]; other site 281090001015 active site 281090001016 putative substrate binding site [chemical binding]; other site 281090001017 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281090001018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281090001019 active site 281090001020 Protein of unknown function (DUF616); Region: DUF616; pfam04765 281090001021 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 281090001022 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 281090001023 Walker A/P-loop; other site 281090001024 ATP binding site [chemical binding]; other site 281090001025 Q-loop/lid; other site 281090001026 ABC transporter signature motif; other site 281090001027 Walker B; other site 281090001028 D-loop; other site 281090001029 H-loop/switch region; other site 281090001030 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 281090001031 putative carbohydrate binding site [chemical binding]; other site 281090001032 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 281090001033 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 281090001034 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 281090001035 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090001036 active site 281090001037 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 281090001038 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 281090001039 active site 281090001040 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 281090001041 homodimer interface [polypeptide binding]; other site 281090001042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090001043 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 281090001044 NAD(P) binding site [chemical binding]; other site 281090001045 active site 281090001046 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 281090001047 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281090001048 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 281090001049 NADP binding site [chemical binding]; other site 281090001050 active site 281090001051 putative substrate binding site [chemical binding]; other site 281090001052 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 281090001053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281090001054 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 281090001055 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281090001056 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 281090001057 Ligand binding site; other site 281090001058 Putative Catalytic site; other site 281090001059 DXD motif; other site 281090001060 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281090001061 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 281090001062 Probable Catalytic site; other site 281090001063 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 281090001064 O-Antigen ligase; Region: Wzy_C; pfam04932 281090001065 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 281090001066 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 281090001067 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 281090001068 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 281090001069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090001070 NAD(P) binding site [chemical binding]; other site 281090001071 active site 281090001072 Transcription factor WhiB; Region: Whib; pfam02467 281090001073 IPT/TIG domain; Region: TIG; pfam01833 281090001074 Putative amidase domain; Region: Amidase_6; pfam12671 281090001075 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 281090001076 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 281090001077 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 281090001078 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 281090001079 active site 281090001080 substrate binding site [chemical binding]; other site 281090001081 metal binding site [ion binding]; metal-binding site 281090001082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090001083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090001084 active site 281090001085 phosphorylation site [posttranslational modification] 281090001086 intermolecular recognition site; other site 281090001087 dimerization interface [polypeptide binding]; other site 281090001088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090001089 DNA binding site [nucleotide binding] 281090001090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281090001091 dimerization interface [polypeptide binding]; other site 281090001092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090001093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090001094 dimer interface [polypeptide binding]; other site 281090001095 phosphorylation site [posttranslational modification] 281090001096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090001097 ATP binding site [chemical binding]; other site 281090001098 Mg2+ binding site [ion binding]; other site 281090001099 G-X-G motif; other site 281090001100 lipoprotein LpqB; Provisional; Region: PRK13615 281090001101 Sporulation and spore germination; Region: Germane; pfam10646 281090001102 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 281090001103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090001104 active site 281090001105 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 281090001106 30S subunit binding site; other site 281090001107 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 281090001108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 281090001109 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 281090001110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 281090001111 nucleotide binding region [chemical binding]; other site 281090001112 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 281090001113 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090001114 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090001115 Integrase core domain; Region: rve; pfam00665 281090001116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 281090001117 Transglycosylase; Region: Transgly; pfam00912 281090001118 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 281090001119 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 281090001120 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090001121 CGNR zinc finger; Region: zf-CGNR; pfam11706 281090001122 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 281090001123 transposase; Provisional; Region: PRK06526 281090001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090001125 Walker A motif; other site 281090001126 ATP binding site [chemical binding]; other site 281090001127 Walker B motif; other site 281090001128 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 281090001129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090001130 active site 281090001131 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 281090001132 ATP-NAD kinase; Region: NAD_kinase; pfam01513 281090001133 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 281090001134 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 281090001135 Walker A/P-loop; other site 281090001136 ATP binding site [chemical binding]; other site 281090001137 Q-loop/lid; other site 281090001138 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 281090001139 ABC transporter signature motif; other site 281090001140 Walker B; other site 281090001141 D-loop; other site 281090001142 H-loop/switch region; other site 281090001143 CTP synthetase; Validated; Region: pyrG; PRK05380 281090001144 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 281090001145 Catalytic site [active] 281090001146 active site 281090001147 UTP binding site [chemical binding]; other site 281090001148 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 281090001149 active site 281090001150 putative oxyanion hole; other site 281090001151 catalytic triad [active] 281090001152 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 281090001153 dimer interface [polypeptide binding]; other site 281090001154 ADP-ribose binding site [chemical binding]; other site 281090001155 active site 281090001156 nudix motif; other site 281090001157 metal binding site [ion binding]; metal-binding site 281090001158 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 281090001159 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090001160 active site 281090001161 DNA binding site [nucleotide binding] 281090001162 Int/Topo IB signature motif; other site 281090001163 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 281090001164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 281090001165 P-loop; other site 281090001166 Magnesium ion binding site [ion binding]; other site 281090001167 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 281090001168 Magnesium ion binding site [ion binding]; other site 281090001169 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 281090001170 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 281090001171 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 281090001172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281090001173 RNA binding surface [nucleotide binding]; other site 281090001174 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 281090001175 active site 281090001176 prephenate dehydrogenase; Validated; Region: PRK06545 281090001177 prephenate dehydrogenase; Validated; Region: PRK08507 281090001178 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 281090001179 cytidylate kinase; Provisional; Region: cmk; PRK00023 281090001180 AAA domain; Region: AAA_17; pfam13207 281090001181 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 281090001182 CMP-binding site; other site 281090001183 The sites determining sugar specificity; other site 281090001184 GTP-binding protein Der; Reviewed; Region: PRK03003 281090001185 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 281090001186 G1 box; other site 281090001187 GTP/Mg2+ binding site [chemical binding]; other site 281090001188 Switch I region; other site 281090001189 G2 box; other site 281090001190 Switch II region; other site 281090001191 G3 box; other site 281090001192 G4 box; other site 281090001193 G5 box; other site 281090001194 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 281090001195 G1 box; other site 281090001196 GTP/Mg2+ binding site [chemical binding]; other site 281090001197 Switch I region; other site 281090001198 G2 box; other site 281090001199 G3 box; other site 281090001200 Switch II region; other site 281090001201 G4 box; other site 281090001202 G5 box; other site 281090001203 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281090001204 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281090001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090001206 dimer interface [polypeptide binding]; other site 281090001207 conserved gate region; other site 281090001208 putative PBP binding loops; other site 281090001209 ABC-ATPase subunit interface; other site 281090001210 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090001211 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 281090001212 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 281090001213 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 281090001214 catalytic residues [active] 281090001215 Part of AAA domain; Region: AAA_19; pfam13245 281090001216 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 281090001217 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 281090001218 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 281090001219 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 281090001220 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 281090001221 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 281090001222 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 281090001223 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 281090001224 active site 281090001225 tetramer interface; other site 281090001226 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 281090001227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 281090001228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090001229 dimerization interface [polypeptide binding]; other site 281090001230 putative DNA binding site [nucleotide binding]; other site 281090001231 putative Zn2+ binding site [ion binding]; other site 281090001232 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090001233 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090001234 Integrase core domain; Region: rve; pfam00665 281090001235 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 281090001236 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 281090001237 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 281090001238 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 281090001239 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 281090001240 dimer interface [polypeptide binding]; other site 281090001241 motif 1; other site 281090001242 active site 281090001243 motif 2; other site 281090001244 motif 3; other site 281090001245 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 281090001246 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 281090001247 putative tRNA-binding site [nucleotide binding]; other site 281090001248 B3/4 domain; Region: B3_4; pfam03483 281090001249 tRNA synthetase B5 domain; Region: B5; smart00874 281090001250 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 281090001251 dimer interface [polypeptide binding]; other site 281090001252 motif 1; other site 281090001253 motif 3; other site 281090001254 motif 2; other site 281090001255 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 281090001256 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 281090001257 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 281090001258 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 281090001259 heterotetramer interface [polypeptide binding]; other site 281090001260 active site pocket [active] 281090001261 cleavage site 281090001262 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 281090001263 homohexameric interface [polypeptide binding]; other site 281090001264 feedback inhibition sensing region; other site 281090001265 nucleotide binding site [chemical binding]; other site 281090001266 N-acetyl-L-glutamate binding site [chemical binding]; other site 281090001267 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 281090001268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281090001269 inhibitor-cofactor binding pocket; inhibition site 281090001270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090001271 catalytic residue [active] 281090001272 ornithine carbamoyltransferase; Provisional; Region: PRK00779 281090001273 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 281090001274 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 281090001275 argininosuccinate lyase; Provisional; Region: PRK00855 281090001276 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 281090001277 active sites [active] 281090001278 tetramer interface [polypeptide binding]; other site 281090001279 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 281090001280 active site 281090001281 DNA binding site [nucleotide binding] 281090001282 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 281090001283 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 281090001284 active site 281090001285 HIGH motif; other site 281090001286 dimer interface [polypeptide binding]; other site 281090001287 KMSKS motif; other site 281090001288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 281090001289 RNA binding surface [nucleotide binding]; other site 281090001290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281090001291 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 281090001292 putative ADP-binding pocket [chemical binding]; other site 281090001293 hemolysin TlyA family protein; Region: tly; TIGR00478 281090001294 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 281090001295 FliW protein; Region: FliW; cl00740 281090001296 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 281090001297 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 281090001298 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 281090001299 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 281090001300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090001301 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281090001302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281090001303 DNA binding residues [nucleotide binding] 281090001304 flagellin; Provisional; Region: PRK12804 281090001305 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 281090001306 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 281090001307 Flagellar protein FliS; Region: FliS; cl00654 281090001308 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 281090001309 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 281090001310 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 281090001311 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 281090001312 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 281090001313 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 281090001314 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 281090001315 FliG C-terminal domain; Region: FliG_C; pfam01706 281090001316 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 281090001317 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 281090001318 Walker A motif/ATP binding site; other site 281090001319 Walker B motif; other site 281090001320 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 281090001321 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 281090001322 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 281090001323 Flagellar protein (FlbD); Region: FlbD; pfam06289 281090001324 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 281090001325 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 281090001326 Global regulator protein family; Region: CsrA; pfam02599 281090001327 enoyl-CoA hydratase; Provisional; Region: PRK06563 281090001328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281090001329 substrate binding site [chemical binding]; other site 281090001330 oxyanion hole (OAH) forming residues; other site 281090001331 trimer interface [polypeptide binding]; other site 281090001332 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 281090001333 active site 281090001334 Mn binding site [ion binding]; other site 281090001335 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281090001336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090001337 NAD(P) binding site [chemical binding]; other site 281090001338 active site 281090001339 methionine sulfoxide reductase B; Provisional; Region: PRK00222 281090001340 SelR domain; Region: SelR; pfam01641 281090001341 methionine sulfoxide reductase A; Provisional; Region: PRK14054 281090001342 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 281090001343 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 281090001344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 281090001345 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 281090001346 putative substrate binding site [chemical binding]; other site 281090001347 putative ATP binding site [chemical binding]; other site 281090001348 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 281090001349 active site 281090001350 phosphorylation site [posttranslational modification] 281090001351 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 281090001352 active site 281090001353 P-loop; other site 281090001354 phosphorylation site [posttranslational modification] 281090001355 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 281090001356 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 281090001357 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281090001358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090001359 DNA-binding site [nucleotide binding]; DNA binding site 281090001360 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 281090001361 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 281090001362 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 281090001363 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 281090001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090001365 dimer interface [polypeptide binding]; other site 281090001366 conserved gate region; other site 281090001367 putative PBP binding loops; other site 281090001368 ABC-ATPase subunit interface; other site 281090001369 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281090001370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090001371 dimer interface [polypeptide binding]; other site 281090001372 conserved gate region; other site 281090001373 ABC-ATPase subunit interface; other site 281090001374 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 281090001375 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090001376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281090001377 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 281090001378 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 281090001379 active site 281090001380 HIGH motif; other site 281090001381 KMSKS motif; other site 281090001382 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 281090001383 tRNA binding surface [nucleotide binding]; other site 281090001384 anticodon binding site; other site 281090001385 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 281090001386 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 281090001387 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 281090001388 active site 281090001389 HIGH motif; other site 281090001390 KMSK motif region; other site 281090001391 tRNA binding surface [nucleotide binding]; other site 281090001392 DALR anticodon binding domain; Region: DALR_1; smart00836 281090001393 anticodon binding site; other site 281090001394 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 281090001395 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 281090001396 H+ Antiporter protein; Region: 2A0121; TIGR00900 281090001397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090001398 putative substrate translocation pore; other site 281090001399 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 281090001400 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 281090001401 diaminopimelate decarboxylase; Region: lysA; TIGR01048 281090001402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 281090001403 active site 281090001404 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281090001405 substrate binding site [chemical binding]; other site 281090001406 catalytic residues [active] 281090001407 dimer interface [polypeptide binding]; other site 281090001408 homoserine dehydrogenase; Provisional; Region: PRK06349 281090001409 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 281090001410 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 281090001411 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 281090001412 threonine synthase; Reviewed; Region: PRK06721 281090001413 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 281090001414 homodimer interface [polypeptide binding]; other site 281090001415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090001416 catalytic residue [active] 281090001417 homoserine kinase; Provisional; Region: PRK01212 281090001418 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 281090001419 Transcription termination factor [Transcription]; Region: Rho; COG1158 281090001420 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 281090001421 RNA binding site [nucleotide binding]; other site 281090001422 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 281090001423 multimer interface [polypeptide binding]; other site 281090001424 Walker A motif; other site 281090001425 ATP binding site [chemical binding]; other site 281090001426 Walker B motif; other site 281090001427 peptide chain release factor 1; Validated; Region: prfA; PRK00591 281090001428 This domain is found in peptide chain release factors; Region: PCRF; smart00937 281090001429 RF-1 domain; Region: RF-1; pfam00472 281090001430 serine O-acetyltransferase; Region: cysE; TIGR01172 281090001431 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 281090001432 trimer interface [polypeptide binding]; other site 281090001433 active site 281090001434 substrate binding site [chemical binding]; other site 281090001435 CoA binding site [chemical binding]; other site 281090001436 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 281090001437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090001438 S-adenosylmethionine binding site [chemical binding]; other site 281090001439 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 281090001440 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 281090001441 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 281090001442 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 281090001443 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 281090001444 Mg++ binding site [ion binding]; other site 281090001445 putative catalytic motif [active] 281090001446 substrate binding site [chemical binding]; other site 281090001447 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 281090001448 ATP synthase subunit C; Region: ATP-synt_C; cl00466 281090001449 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 281090001450 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 281090001451 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 281090001452 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 281090001453 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 281090001454 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 281090001455 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 281090001456 beta subunit interaction interface [polypeptide binding]; other site 281090001457 Walker A motif; other site 281090001458 ATP binding site [chemical binding]; other site 281090001459 Walker B motif; other site 281090001460 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 281090001461 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 281090001462 core domain interface [polypeptide binding]; other site 281090001463 delta subunit interface [polypeptide binding]; other site 281090001464 epsilon subunit interface [polypeptide binding]; other site 281090001465 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 281090001466 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 281090001467 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 281090001468 alpha subunit interaction interface [polypeptide binding]; other site 281090001469 Walker A motif; other site 281090001470 ATP binding site [chemical binding]; other site 281090001471 Walker B motif; other site 281090001472 inhibitor binding site; inhibition site 281090001473 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 281090001474 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 281090001475 gamma subunit interface [polypeptide binding]; other site 281090001476 epsilon subunit interface [polypeptide binding]; other site 281090001477 LBP interface [polypeptide binding]; other site 281090001478 AAA domain; Region: AAA_33; pfam13671 281090001479 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 281090001480 active site 281090001481 hypothetical protein; Validated; Region: PRK02101 281090001482 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 281090001483 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 281090001484 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 281090001485 DNA binding site [nucleotide binding] 281090001486 active site 281090001487 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 281090001488 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 281090001489 active site 281090001490 catalytic triad [active] 281090001491 calcium binding site [ion binding]; other site 281090001492 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 281090001493 NusA N-terminal domain; Region: NusA_N; pfam08529 281090001494 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 281090001495 RNA binding site [nucleotide binding]; other site 281090001496 homodimer interface [polypeptide binding]; other site 281090001497 NusA-like KH domain; Region: KH_5; pfam13184 281090001498 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 281090001499 G-X-X-G motif; other site 281090001500 Protein of unknown function (DUF448); Region: DUF448; pfam04296 281090001501 putative RNA binding cleft [nucleotide binding]; other site 281090001502 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 281090001503 translation initiation factor IF-2; Region: IF-2; TIGR00487 281090001504 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 281090001505 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 281090001506 G1 box; other site 281090001507 putative GEF interaction site [polypeptide binding]; other site 281090001508 GTP/Mg2+ binding site [chemical binding]; other site 281090001509 Switch I region; other site 281090001510 G2 box; other site 281090001511 G3 box; other site 281090001512 Switch II region; other site 281090001513 G4 box; other site 281090001514 G5 box; other site 281090001515 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 281090001516 Translation-initiation factor 2; Region: IF-2; pfam11987 281090001517 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 281090001518 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 281090001519 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 281090001520 endonuclease III; Region: ENDO3c; smart00478 281090001521 minor groove reading motif; other site 281090001522 helix-hairpin-helix signature motif; other site 281090001523 substrate binding pocket [chemical binding]; other site 281090001524 active site 281090001525 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 281090001526 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 281090001527 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 281090001528 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 281090001529 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 281090001530 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 281090001531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090001532 motif II; other site 281090001533 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 281090001534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090001535 DNA-binding site [nucleotide binding]; DNA binding site 281090001536 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 281090001537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090001538 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 281090001539 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 281090001540 RNA binding site [nucleotide binding]; other site 281090001541 active site 281090001542 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 281090001543 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 281090001544 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 281090001545 active site 281090001546 Riboflavin kinase; Region: Flavokinase; pfam01687 281090001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090001548 putative substrate translocation pore; other site 281090001549 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 281090001550 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 281090001551 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 281090001552 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 281090001553 intersubunit interface [polypeptide binding]; other site 281090001554 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 281090001555 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 281090001556 active site 281090001557 catalytic triad [active] 281090001558 oxyanion hole [active] 281090001559 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 281090001560 putative ADP-ribose binding site [chemical binding]; other site 281090001561 putative active site [active] 281090001562 putative homodimer interface [polypeptide binding]; other site 281090001563 putative homotetramer interface [polypeptide binding]; other site 281090001564 Metal-sensitive transcriptional repressor; Region: Trns_repr_metal; pfam02583 281090001565 putative allosteric switch controlling residues; other site 281090001566 putative metal binding site [ion binding]; other site 281090001567 putative homodimer-homodimer interface [polypeptide binding]; other site 281090001568 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281090001569 metal-binding site [ion binding] 281090001570 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 281090001571 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 281090001572 metal-binding site [ion binding] 281090001573 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281090001574 Soluble P-type ATPase [General function prediction only]; Region: COG4087 281090001575 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 281090001576 catalytic residues [active] 281090001577 catalytic nucleophile [active] 281090001578 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281090001579 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 281090001580 catalytic residues [active] 281090001581 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281090001582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090001583 ATP binding site [chemical binding]; other site 281090001584 putative Mg++ binding site [ion binding]; other site 281090001585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090001586 nucleotide binding region [chemical binding]; other site 281090001587 ATP-binding site [chemical binding]; other site 281090001588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090001589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090001590 active site 281090001591 phosphorylation site [posttranslational modification] 281090001592 intermolecular recognition site; other site 281090001593 dimerization interface [polypeptide binding]; other site 281090001594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090001595 DNA binding residues [nucleotide binding] 281090001596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281090001597 Histidine kinase; Region: HisKA_3; pfam07730 281090001598 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 281090001599 ATP binding site [chemical binding]; other site 281090001600 Mg2+ binding site [ion binding]; other site 281090001601 G-X-G motif; other site 281090001602 phosphofructokinase; Region: PFK_mixed; TIGR02483 281090001603 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 281090001604 active site 281090001605 ADP/pyrophosphate binding site [chemical binding]; other site 281090001606 dimerization interface [polypeptide binding]; other site 281090001607 allosteric effector site; other site 281090001608 fructose-1,6-bisphosphate binding site; other site 281090001609 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 281090001610 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 281090001611 putative NAD(P) binding site [chemical binding]; other site 281090001612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281090001613 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 281090001614 dimerization interface [polypeptide binding]; other site 281090001615 AAA-like domain; Region: AAA_10; pfam12846 281090001616 Surface antigen [General function prediction only]; Region: COG3942 281090001617 CHAP domain; Region: CHAP; cl17642 281090001618 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 281090001619 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 281090001620 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 281090001621 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 281090001622 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 281090001623 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 281090001624 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 281090001625 putative dimer interface [polypeptide binding]; other site 281090001626 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090001627 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090001628 Integrase core domain; Region: rve; pfam00665 281090001629 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 281090001630 active site 281090001631 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090001632 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 281090001633 trigger factor; Provisional; Region: tig; PRK01490 281090001634 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 281090001635 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 281090001636 Tetratrico peptide repeat; Region: TPR_5; pfam12688 281090001637 Clp protease; Region: CLP_protease; pfam00574 281090001638 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 281090001639 oligomer interface [polypeptide binding]; other site 281090001640 active site residues [active] 281090001641 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 281090001642 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 281090001643 oligomer interface [polypeptide binding]; other site 281090001644 active site residues [active] 281090001645 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 281090001646 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 281090001647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090001648 Walker A motif; other site 281090001649 ATP binding site [chemical binding]; other site 281090001650 Walker B motif; other site 281090001651 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 281090001652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281090001653 Coenzyme A binding pocket [chemical binding]; other site 281090001654 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 281090001655 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 281090001656 active site 281090001657 HIGH motif; other site 281090001658 nucleotide binding site [chemical binding]; other site 281090001659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 281090001660 active site 281090001661 KMSKS motif; other site 281090001662 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 281090001663 tRNA binding surface [nucleotide binding]; other site 281090001664 anticodon binding site; other site 281090001665 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 281090001666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090001667 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 281090001668 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 281090001669 HIGH motif; other site 281090001670 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 281090001671 active site 281090001672 KMSKS motif; other site 281090001673 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 281090001674 tRNA binding surface [nucleotide binding]; other site 281090001675 anticodon binding site; other site 281090001676 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 281090001677 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281090001678 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281090001679 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 281090001680 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 281090001681 active site 281090001682 multimer interface [polypeptide binding]; other site 281090001683 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 281090001684 putative active site [active] 281090001685 redox center [active] 281090001686 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 281090001687 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 281090001688 homodimer interface [polypeptide binding]; other site 281090001689 oligonucleotide binding site [chemical binding]; other site 281090001690 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 281090001691 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 281090001692 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 281090001693 GTPase CgtA; Reviewed; Region: obgE; PRK12296 281090001694 GTP1/OBG; Region: GTP1_OBG; pfam01018 281090001695 Obg GTPase; Region: Obg; cd01898 281090001696 G1 box; other site 281090001697 GTP/Mg2+ binding site [chemical binding]; other site 281090001698 Switch I region; other site 281090001699 G2 box; other site 281090001700 G3 box; other site 281090001701 Switch II region; other site 281090001702 G4 box; other site 281090001703 G5 box; other site 281090001704 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 281090001705 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 281090001706 homotetrameric interface [polypeptide binding]; other site 281090001707 putative phosphate binding site [ion binding]; other site 281090001708 putative allosteric binding site; other site 281090001709 nucleotide binding site [chemical binding]; other site 281090001710 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 281090001711 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 281090001712 putative catalytic cysteine [active] 281090001713 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 281090001714 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 281090001715 active site 281090001716 (T/H)XGH motif; other site 281090001717 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 281090001718 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 281090001719 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 281090001720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090001721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281090001722 putative substrate translocation pore; other site 281090001723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090001724 Uncharacterized conserved protein [Function unknown]; Region: COG2353 281090001725 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 281090001726 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 281090001727 diiron binding motif [ion binding]; other site 281090001728 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 281090001729 PAC2 family; Region: PAC2; pfam09754 281090001730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090001731 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 281090001732 active site 281090001733 motif I; other site 281090001734 motif II; other site 281090001735 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 281090001736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090001737 S-adenosylmethionine binding site [chemical binding]; other site 281090001738 Predicted transcriptional regulator [Transcription]; Region: COG2378 281090001739 WYL domain; Region: WYL; pfam13280 281090001740 Predicted transcriptional regulator [Transcription]; Region: COG2378 281090001741 WYL domain; Region: WYL; pfam13280 281090001742 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 281090001743 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 281090001744 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281090001745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090001746 ATP binding site [chemical binding]; other site 281090001747 putative Mg++ binding site [ion binding]; other site 281090001748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090001749 nucleotide binding region [chemical binding]; other site 281090001750 ATP-binding site [chemical binding]; other site 281090001751 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 281090001752 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 281090001753 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 281090001754 putative active site [active] 281090001755 catalytic triad [active] 281090001756 putative dimer interface [polypeptide binding]; other site 281090001757 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 281090001758 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 281090001759 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 281090001760 short chain dehydrogenase; Provisional; Region: PRK07806 281090001761 NAD(P) binding site [chemical binding]; other site 281090001762 active site 281090001763 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 281090001764 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 281090001765 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 281090001766 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 281090001767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090001768 dimerization interface [polypeptide binding]; other site 281090001769 putative DNA binding site [nucleotide binding]; other site 281090001770 putative Zn2+ binding site [ion binding]; other site 281090001771 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 281090001772 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 281090001773 FMN binding site [chemical binding]; other site 281090001774 active site 281090001775 catalytic residues [active] 281090001776 substrate binding site [chemical binding]; other site 281090001777 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 281090001778 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281090001779 Zn2+ binding site [ion binding]; other site 281090001780 Mg2+ binding site [ion binding]; other site 281090001781 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 281090001782 DNA primase; Validated; Region: dnaG; PRK05667 281090001783 CHC2 zinc finger; Region: zf-CHC2; pfam01807 281090001784 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 281090001785 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 281090001786 active site 281090001787 metal binding site [ion binding]; metal-binding site 281090001788 interdomain interaction site; other site 281090001789 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 281090001790 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 281090001791 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 281090001792 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281090001793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090001794 dimer interface [polypeptide binding]; other site 281090001795 conserved gate region; other site 281090001796 ABC-ATPase subunit interface; other site 281090001797 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 281090001798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090001799 dimer interface [polypeptide binding]; other site 281090001800 conserved gate region; other site 281090001801 ABC-ATPase subunit interface; other site 281090001802 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 281090001803 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090001804 Walker A/P-loop; other site 281090001805 ATP binding site [chemical binding]; other site 281090001806 Q-loop/lid; other site 281090001807 ABC transporter signature motif; other site 281090001808 Walker B; other site 281090001809 D-loop; other site 281090001810 H-loop/switch region; other site 281090001811 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281090001812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090001813 Walker A/P-loop; other site 281090001814 ATP binding site [chemical binding]; other site 281090001815 Q-loop/lid; other site 281090001816 ABC transporter signature motif; other site 281090001817 Walker B; other site 281090001818 D-loop; other site 281090001819 H-loop/switch region; other site 281090001820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281090001821 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 281090001822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090001823 Walker A/P-loop; other site 281090001824 ATP binding site [chemical binding]; other site 281090001825 Q-loop/lid; other site 281090001826 ABC transporter signature motif; other site 281090001827 Walker B; other site 281090001828 D-loop; other site 281090001829 H-loop/switch region; other site 281090001830 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 281090001831 putative ligand binding site [chemical binding]; other site 281090001832 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 281090001833 putative NAD binding site [chemical binding]; other site 281090001834 catalytic site [active] 281090001835 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 281090001836 active site 281090001837 catalytic residues [active] 281090001838 metal binding site [ion binding]; metal-binding site 281090001839 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 281090001840 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 281090001841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281090001842 putative ADP-binding pocket [chemical binding]; other site 281090001843 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 281090001844 nudix motif; other site 281090001845 NUDIX domain; Region: NUDIX; pfam00293 281090001846 nudix motif; other site 281090001847 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 281090001848 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 281090001849 active site 281090001850 DNA binding site [nucleotide binding] 281090001851 catalytic site [active] 281090001852 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 281090001853 Predicted transcriptional regulators [Transcription]; Region: COG1695 281090001854 Transcriptional regulator PadR-like family; Region: PadR; cl17335 281090001855 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 281090001856 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 281090001857 apolar tunnel; other site 281090001858 heme binding site [chemical binding]; other site 281090001859 dimerization interface [polypeptide binding]; other site 281090001860 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 281090001861 Mechanosensitive ion channel; Region: MS_channel; pfam00924 281090001862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090001863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090001864 active site 281090001865 phosphorylation site [posttranslational modification] 281090001866 intermolecular recognition site; other site 281090001867 dimerization interface [polypeptide binding]; other site 281090001868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090001869 DNA binding residues [nucleotide binding] 281090001870 dimerization interface [polypeptide binding]; other site 281090001871 Histidine kinase; Region: HisKA_3; pfam07730 281090001872 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 281090001873 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 281090001874 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 281090001875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 281090001876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090001877 Walker A/P-loop; other site 281090001878 ATP binding site [chemical binding]; other site 281090001879 Q-loop/lid; other site 281090001880 ABC transporter signature motif; other site 281090001881 Walker B; other site 281090001882 D-loop; other site 281090001883 H-loop/switch region; other site 281090001884 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 281090001885 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 281090001886 Zn binding site [ion binding]; other site 281090001887 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 281090001888 endonuclease VIII; Provisional; Region: PRK10445 281090001889 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 281090001890 putative DNA binding site [nucleotide binding]; other site 281090001891 catalytic residue [active] 281090001892 putative H2TH interface [polypeptide binding]; other site 281090001893 putative catalytic residues [active] 281090001894 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 281090001895 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 281090001896 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 281090001897 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 281090001898 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 281090001899 dimerization interface [polypeptide binding]; other site 281090001900 DPS ferroxidase diiron center [ion binding]; other site 281090001901 ion pore; other site 281090001902 proline/glycine betaine transporter; Provisional; Region: PRK10642 281090001903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090001904 putative substrate translocation pore; other site 281090001905 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090001906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090001907 active site 281090001908 Int/Topo IB signature motif; other site 281090001909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090001910 active site 281090001911 Int/Topo IB signature motif; other site 281090001912 DNA binding site [nucleotide binding] 281090001913 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 281090001914 uracil transporter; Provisional; Region: PRK10720 281090001915 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 281090001916 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 281090001917 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 281090001918 Aspartase; Region: Aspartase; cd01357 281090001919 active sites [active] 281090001920 tetramer interface [polypeptide binding]; other site 281090001921 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 281090001922 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 281090001923 FAD binding domain; Region: FAD_binding_4; pfam01565 281090001924 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 281090001925 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 281090001926 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 281090001927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090001928 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 281090001929 16S/18S rRNA binding site [nucleotide binding]; other site 281090001930 S13e-L30e interaction site [polypeptide binding]; other site 281090001931 25S rRNA binding site [nucleotide binding]; other site 281090001932 VanZ like family; Region: VanZ; cl01971 281090001933 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 281090001934 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 281090001935 oligomer interface [polypeptide binding]; other site 281090001936 RNA binding site [nucleotide binding]; other site 281090001937 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 281090001938 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 281090001939 RNase E interface [polypeptide binding]; other site 281090001940 trimer interface [polypeptide binding]; other site 281090001941 active site 281090001942 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 281090001943 putative nucleic acid binding region [nucleotide binding]; other site 281090001944 G-X-X-G motif; other site 281090001945 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 281090001946 RNA binding site [nucleotide binding]; other site 281090001947 domain interface; other site 281090001948 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 281090001949 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 281090001950 putative trimer interface [polypeptide binding]; other site 281090001951 putative CoA binding site [chemical binding]; other site 281090001952 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 281090001953 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 281090001954 metal binding site [ion binding]; metal-binding site 281090001955 putative dimer interface [polypeptide binding]; other site 281090001956 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 281090001957 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 281090001958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090001959 S-adenosylmethionine binding site [chemical binding]; other site 281090001960 Domain of unknown function DUF59; Region: DUF59; cl00941 281090001961 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 281090001962 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 281090001963 Walker A motif; other site 281090001964 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 281090001965 MgtE intracellular N domain; Region: MgtE_N; smart00924 281090001966 FOG: CBS domain [General function prediction only]; Region: COG0517 281090001967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 281090001968 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 281090001969 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 281090001970 active site 281090001971 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 281090001972 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 281090001973 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 281090001974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 281090001975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 281090001976 catalytic residue [active] 281090001977 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 281090001978 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281090001979 ATP binding site [chemical binding]; other site 281090001980 Mg++ binding site [ion binding]; other site 281090001981 motif III; other site 281090001982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090001983 nucleotide binding region [chemical binding]; other site 281090001984 ATP-binding site [chemical binding]; other site 281090001985 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 281090001986 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 281090001987 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 281090001988 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 281090001989 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 281090001990 Part of AAA domain; Region: AAA_19; pfam13245 281090001991 Family description; Region: UvrD_C_2; pfam13538 281090001992 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 281090001993 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 281090001994 active site 281090001995 ATP binding site [chemical binding]; other site 281090001996 Phosphotransferase enzyme family; Region: APH; pfam01636 281090001997 substrate binding site [chemical binding]; other site 281090001998 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 281090001999 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 281090002000 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 281090002001 putative NADH binding site [chemical binding]; other site 281090002002 putative active site [active] 281090002003 nudix motif; other site 281090002004 putative metal binding site [ion binding]; other site 281090002005 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 281090002006 Part of AAA domain; Region: AAA_19; pfam13245 281090002007 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 281090002008 Family description; Region: UvrD_C_2; pfam13538 281090002009 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 281090002010 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 281090002011 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 281090002012 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 281090002013 protein binding site [polypeptide binding]; other site 281090002014 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 281090002015 Uncharacterized conserved protein [Function unknown]; Region: COG1615 281090002016 Response regulator receiver domain; Region: Response_reg; pfam00072 281090002017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090002018 active site 281090002019 phosphorylation site [posttranslational modification] 281090002020 intermolecular recognition site; other site 281090002021 dimerization interface [polypeptide binding]; other site 281090002022 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 281090002023 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 281090002024 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 281090002025 active site 281090002026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090002027 active site 281090002028 phosphorylation site [posttranslational modification] 281090002029 intermolecular recognition site; other site 281090002030 dimerization interface [polypeptide binding]; other site 281090002031 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090002032 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090002033 Integrase core domain; Region: rve; pfam00665 281090002034 MarR family; Region: MarR_2; pfam12802 281090002035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281090002036 MarR family; Region: MarR_2; pfam12802 281090002037 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 281090002038 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 281090002039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281090002040 catalytic residue [active] 281090002041 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 281090002042 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 281090002043 trimerization site [polypeptide binding]; other site 281090002044 active site 281090002045 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 281090002046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090002047 dimer interface [polypeptide binding]; other site 281090002048 conserved gate region; other site 281090002049 ABC-ATPase subunit interface; other site 281090002050 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 281090002051 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 281090002052 DNA photolyase; Region: DNA_photolyase; pfam00875 281090002053 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 281090002054 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 281090002055 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281090002056 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281090002057 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 281090002058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281090002059 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 281090002060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090002061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090002062 active site 281090002063 phosphorylation site [posttranslational modification] 281090002064 intermolecular recognition site; other site 281090002065 dimerization interface [polypeptide binding]; other site 281090002066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090002067 DNA binding residues [nucleotide binding] 281090002068 dimerization interface [polypeptide binding]; other site 281090002069 Protein of unknown function (DUF418); Region: DUF418; cl12135 281090002070 Protein of unknown function (DUF418); Region: DUF418; pfam04235 281090002071 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 281090002072 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 281090002073 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 281090002074 substrate binding site [chemical binding]; other site 281090002075 ligand binding site [chemical binding]; other site 281090002076 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 281090002077 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 281090002078 substrate binding site [chemical binding]; other site 281090002079 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 281090002080 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 281090002081 hinge; other site 281090002082 active site 281090002083 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 281090002084 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 281090002085 putative acyl-acceptor binding pocket; other site 281090002086 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 281090002087 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 281090002088 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 281090002089 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 281090002090 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 281090002091 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 281090002092 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 281090002093 thiamine monophosphate kinase; Provisional; Region: PRK05731 281090002094 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 281090002095 ATP binding site [chemical binding]; other site 281090002096 dimerization interface [polypeptide binding]; other site 281090002097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 281090002098 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 281090002099 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 281090002100 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 281090002101 generic binding surface II; other site 281090002102 ssDNA binding site; other site 281090002103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090002104 ATP binding site [chemical binding]; other site 281090002105 putative Mg++ binding site [ion binding]; other site 281090002106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090002107 nucleotide binding region [chemical binding]; other site 281090002108 ATP-binding site [chemical binding]; other site 281090002109 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 281090002110 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 281090002111 active site 281090002112 (T/H)XGH motif; other site 281090002113 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 281090002114 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 281090002115 ribonuclease III; Reviewed; Region: rnc; PRK00102 281090002116 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 281090002117 dimerization interface [polypeptide binding]; other site 281090002118 active site 281090002119 metal binding site [ion binding]; metal-binding site 281090002120 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 281090002121 dsRNA binding site [nucleotide binding]; other site 281090002122 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 281090002123 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 281090002124 DNA binding site [nucleotide binding] 281090002125 catalytic residue [active] 281090002126 H2TH interface [polypeptide binding]; other site 281090002127 putative catalytic residues [active] 281090002128 turnover-facilitating residue; other site 281090002129 intercalation triad [nucleotide binding]; other site 281090002130 8OG recognition residue [nucleotide binding]; other site 281090002131 putative reading head residues; other site 281090002132 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 281090002133 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 281090002134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090002135 dimerization interface [polypeptide binding]; other site 281090002136 putative DNA binding site [nucleotide binding]; other site 281090002137 putative Zn2+ binding site [ion binding]; other site 281090002138 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 281090002139 heme bH binding site [chemical binding]; other site 281090002140 Qi binding site; other site 281090002141 intrachain domain interface; other site 281090002142 heme bL binding site [chemical binding]; other site 281090002143 interchain domain interface [polypeptide binding]; other site 281090002144 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 281090002145 Qo binding site; other site 281090002146 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 281090002147 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 281090002148 iron-sulfur cluster [ion binding]; other site 281090002149 [2Fe-2S] cluster binding site [ion binding]; other site 281090002150 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 281090002151 Cytochrome c; Region: Cytochrom_C; pfam00034 281090002152 Cytochrome c; Region: Cytochrom_C; pfam00034 281090002153 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 281090002154 Subunit I/III interface [polypeptide binding]; other site 281090002155 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 281090002156 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 281090002157 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 281090002158 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 281090002159 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 281090002160 DAK2 domain; Region: Dak2; cl03685 281090002161 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 281090002162 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 281090002163 dimerization domain swap beta strand [polypeptide binding]; other site 281090002164 regulatory protein interface [polypeptide binding]; other site 281090002165 active site 281090002166 regulatory phosphorylation site [posttranslational modification]; other site 281090002167 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 281090002168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281090002169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090002170 homodimer interface [polypeptide binding]; other site 281090002171 catalytic residue [active] 281090002172 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 281090002173 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 281090002174 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 281090002175 folate binding site [chemical binding]; other site 281090002176 NADP+ binding site [chemical binding]; other site 281090002177 thymidylate synthase; Reviewed; Region: thyA; PRK01827 281090002178 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 281090002179 dimerization interface [polypeptide binding]; other site 281090002180 active site 281090002181 Uncharacterized conserved protein [Function unknown]; Region: COG0327 281090002182 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 281090002183 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 281090002184 Putative zinc ribbon domain; Region: DUF164; pfam02591 281090002185 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090002186 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281090002187 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 281090002188 active site 281090002189 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 281090002190 oligomerization interface [polypeptide binding]; other site 281090002191 active site 281090002192 metal binding site [ion binding]; metal-binding site 281090002193 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 281090002194 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 281090002195 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 281090002196 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 281090002197 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 281090002198 metal binding triad; other site 281090002199 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 281090002200 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 281090002201 metal binding triad; other site 281090002202 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 281090002203 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090002204 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090002205 Integrase core domain; Region: rve; pfam00665 281090002206 glutamine synthetase, type I; Region: GlnA; TIGR00653 281090002207 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 281090002208 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 281090002209 RDD family; Region: RDD; pfam06271 281090002210 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 281090002211 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 281090002212 lipoyl synthase; Provisional; Region: PRK05481 281090002213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281090002214 FeS/SAM binding site; other site 281090002215 lipoate-protein ligase B; Provisional; Region: PRK14345 281090002216 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 281090002217 E3 interaction surface; other site 281090002218 lipoyl attachment site [posttranslational modification]; other site 281090002219 e3 binding domain; Region: E3_binding; pfam02817 281090002220 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 281090002221 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281090002222 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 281090002223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281090002224 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 281090002225 multifunctional aminopeptidase A; Provisional; Region: PRK00913 281090002226 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 281090002227 interface (dimer of trimers) [polypeptide binding]; other site 281090002228 Substrate-binding/catalytic site; other site 281090002229 Zn-binding sites [ion binding]; other site 281090002230 PAC2 family; Region: PAC2; pfam09754 281090002231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090002232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281090002233 putative substrate translocation pore; other site 281090002234 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 281090002235 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 281090002236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090002237 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281090002238 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281090002239 DNA binding residues [nucleotide binding] 281090002240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281090002241 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 281090002242 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 281090002243 catalytic triad [active] 281090002244 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 281090002245 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 281090002246 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 281090002247 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 281090002248 inhibitor site; inhibition site 281090002249 active site 281090002250 dimer interface [polypeptide binding]; other site 281090002251 catalytic residue [active] 281090002252 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 281090002253 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 281090002254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090002255 non-specific DNA binding site [nucleotide binding]; other site 281090002256 salt bridge; other site 281090002257 sequence-specific DNA binding site [nucleotide binding]; other site 281090002258 Cupin domain; Region: Cupin_2; pfam07883 281090002259 SnoaL-like domain; Region: SnoaL_2; pfam12680 281090002260 alanine racemase; Reviewed; Region: alr; PRK00053 281090002261 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 281090002262 active site 281090002263 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281090002264 dimer interface [polypeptide binding]; other site 281090002265 substrate binding site [chemical binding]; other site 281090002266 catalytic residues [active] 281090002267 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 281090002268 catalytic residue [active] 281090002269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 281090002270 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 281090002271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090002272 ATP binding site [chemical binding]; other site 281090002273 Mg2+ binding site [ion binding]; other site 281090002274 G-X-G motif; other site 281090002275 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 281090002276 anchoring element; other site 281090002277 dimer interface [polypeptide binding]; other site 281090002278 ATP binding site [chemical binding]; other site 281090002279 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 281090002280 active site 281090002281 metal binding site [ion binding]; metal-binding site 281090002282 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 281090002283 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 281090002284 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 281090002285 CAP-like domain; other site 281090002286 active site 281090002287 primary dimer interface [polypeptide binding]; other site 281090002288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 281090002289 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 281090002290 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 281090002291 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 281090002292 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 281090002293 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 281090002294 trimer interface [polypeptide binding]; other site 281090002295 active site 281090002296 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 281090002297 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 281090002298 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 281090002299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281090002300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090002301 motif II; other site 281090002302 aconitate hydratase; Validated; Region: PRK09277 281090002303 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 281090002304 substrate binding site [chemical binding]; other site 281090002305 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 281090002306 ligand binding site [chemical binding]; other site 281090002307 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 281090002308 substrate binding site [chemical binding]; other site 281090002309 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 281090002310 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 281090002311 TPP-binding site; other site 281090002312 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 281090002313 PYR/PP interface [polypeptide binding]; other site 281090002314 dimer interface [polypeptide binding]; other site 281090002315 TPP binding site [chemical binding]; other site 281090002316 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281090002317 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 281090002318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 281090002319 substrate binding site [chemical binding]; other site 281090002320 oxyanion hole (OAH) forming residues; other site 281090002321 trimer interface [polypeptide binding]; other site 281090002322 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 281090002323 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 281090002324 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 281090002325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 281090002326 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 281090002327 dimer interface [polypeptide binding]; other site 281090002328 active site 281090002329 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 281090002330 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 281090002331 catalytic site [active] 281090002332 putative active site [active] 281090002333 putative substrate binding site [chemical binding]; other site 281090002334 HRDC domain; Region: HRDC; cl02578 281090002335 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 281090002336 Fe-S metabolism associated domain; Region: SufE; cl00951 281090002337 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 281090002338 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 281090002339 active site residue [active] 281090002340 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 281090002341 active site residue [active] 281090002342 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 281090002343 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 281090002344 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 281090002345 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 281090002346 nudix motif; other site 281090002347 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 281090002348 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 281090002349 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 281090002350 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 281090002351 active site 281090002352 dimer interface [polypeptide binding]; other site 281090002353 motif 1; other site 281090002354 motif 2; other site 281090002355 motif 3; other site 281090002356 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 281090002357 anticodon binding site; other site 281090002358 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 281090002359 nucleotide binding site/active site [active] 281090002360 HIT family signature motif; other site 281090002361 catalytic residue [active] 281090002362 pyridoxamine kinase; Validated; Region: PRK05756 281090002363 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 281090002364 dimer interface [polypeptide binding]; other site 281090002365 pyridoxal binding site [chemical binding]; other site 281090002366 ATP binding site [chemical binding]; other site 281090002367 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 281090002368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090002369 DNA-binding site [nucleotide binding]; DNA binding site 281090002370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281090002371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090002372 homodimer interface [polypeptide binding]; other site 281090002373 catalytic residue [active] 281090002374 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 281090002375 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 281090002376 active site 281090002377 multimer interface [polypeptide binding]; other site 281090002378 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 281090002379 predicted active site [active] 281090002380 catalytic triad [active] 281090002381 hypothetical protein; Validated; Region: PRK00110 281090002382 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 281090002383 active site 281090002384 putative DNA-binding cleft [nucleotide binding]; other site 281090002385 dimer interface [polypeptide binding]; other site 281090002386 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 281090002387 RuvA N terminal domain; Region: RuvA_N; pfam01330 281090002388 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 281090002389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090002390 Walker A motif; other site 281090002391 ATP binding site [chemical binding]; other site 281090002392 Walker B motif; other site 281090002393 arginine finger; other site 281090002394 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 281090002395 Preprotein translocase subunit; Region: YajC; pfam02699 281090002396 protein-export membrane protein SecD; Region: secD; TIGR01129 281090002397 Protein export membrane protein; Region: SecD_SecF; cl14618 281090002398 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 281090002399 Protein export membrane protein; Region: SecD_SecF; pfam02355 281090002400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 281090002401 active site residue [active] 281090002402 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 281090002403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281090002404 Zn2+ binding site [ion binding]; other site 281090002405 Mg2+ binding site [ion binding]; other site 281090002406 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 281090002407 synthetase active site [active] 281090002408 NTP binding site [chemical binding]; other site 281090002409 metal binding site [ion binding]; metal-binding site 281090002410 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 281090002411 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 281090002412 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 281090002413 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 281090002414 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 281090002415 active site 281090002416 recombination factor protein RarA; Reviewed; Region: PRK13342 281090002417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090002418 Walker A motif; other site 281090002419 ATP binding site [chemical binding]; other site 281090002420 Walker B motif; other site 281090002421 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 281090002422 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 281090002423 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 281090002424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281090002425 RNA binding surface [nucleotide binding]; other site 281090002426 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 281090002427 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 281090002428 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 281090002429 motif 1; other site 281090002430 active site 281090002431 motif 2; other site 281090002432 motif 3; other site 281090002433 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 281090002434 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 281090002435 YceG-like family; Region: YceG; pfam02618 281090002436 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 281090002437 dimerization interface [polypeptide binding]; other site 281090002438 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 281090002439 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 281090002440 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 281090002441 shikimate binding site; other site 281090002442 NAD(P) binding site [chemical binding]; other site 281090002443 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 281090002444 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 281090002445 Tetramer interface [polypeptide binding]; other site 281090002446 active site 281090002447 FMN-binding site [chemical binding]; other site 281090002448 shikimate kinase; Reviewed; Region: aroK; PRK00131 281090002449 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 281090002450 ADP binding site [chemical binding]; other site 281090002451 magnesium binding site [ion binding]; other site 281090002452 putative shikimate binding site; other site 281090002453 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 281090002454 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 281090002455 active site 281090002456 dimer interface [polypeptide binding]; other site 281090002457 metal binding site [ion binding]; metal-binding site 281090002458 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 281090002459 Dehydroquinase class II; Region: DHquinase_II; pfam01220 281090002460 trimer interface [polypeptide binding]; other site 281090002461 active site 281090002462 dimer interface [polypeptide binding]; other site 281090002463 elongation factor P; Validated; Region: PRK00529 281090002464 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 281090002465 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 281090002466 RNA binding site [nucleotide binding]; other site 281090002467 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 281090002468 RNA binding site [nucleotide binding]; other site 281090002469 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 281090002470 putative RNA binding site [nucleotide binding]; other site 281090002471 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 281090002472 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 281090002473 catalytic residues [active] 281090002474 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 281090002475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090002476 active site 281090002477 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 281090002478 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 281090002479 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 281090002480 dihydroorotase; Validated; Region: pyrC; PRK09357 281090002481 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 281090002482 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 281090002483 active site 281090002484 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 281090002485 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 281090002486 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 281090002487 catalytic site [active] 281090002488 subunit interface [polypeptide binding]; other site 281090002489 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 281090002490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281090002491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281090002492 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 281090002493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281090002494 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281090002495 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 281090002496 IMP binding site; other site 281090002497 dimer interface [polypeptide binding]; other site 281090002498 interdomain contacts; other site 281090002499 partial ornithine binding site; other site 281090002500 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 281090002501 active site 281090002502 dimer interface [polypeptide binding]; other site 281090002503 Guanylate kinase; Region: Guanylate_kin; pfam00625 281090002504 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 281090002505 catalytic site [active] 281090002506 G-X2-G-X-G-K; other site 281090002507 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 281090002508 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 281090002509 Flavoprotein; Region: Flavoprotein; pfam02441 281090002510 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 281090002511 S-adenosylmethionine synthetase; Validated; Region: PRK05250 281090002512 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 281090002513 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 281090002514 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 281090002515 primosome assembly protein PriA; Provisional; Region: PRK14873 281090002516 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 281090002517 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 281090002518 putative active site [active] 281090002519 substrate binding site [chemical binding]; other site 281090002520 putative cosubstrate binding site; other site 281090002521 catalytic site [active] 281090002522 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 281090002523 substrate binding site [chemical binding]; other site 281090002524 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 281090002525 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 281090002526 substrate binding site [chemical binding]; other site 281090002527 hexamer interface [polypeptide binding]; other site 281090002528 metal binding site [ion binding]; metal-binding site 281090002529 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 281090002530 homodimer interface [polypeptide binding]; other site 281090002531 putative metal binding site [ion binding]; other site 281090002532 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 281090002533 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 281090002534 HisG, C-terminal domain; Region: HisG_C; pfam08029 281090002535 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 281090002536 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 281090002537 substrate binding site [chemical binding]; other site 281090002538 glutamase interaction surface [polypeptide binding]; other site 281090002539 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 281090002540 anthranilate synthase component I; Provisional; Region: PRK13571 281090002541 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 281090002542 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 281090002543 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 281090002544 active site 281090002545 ribulose/triose binding site [chemical binding]; other site 281090002546 phosphate binding site [ion binding]; other site 281090002547 substrate (anthranilate) binding pocket [chemical binding]; other site 281090002548 product (indole) binding pocket [chemical binding]; other site 281090002549 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 281090002550 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 281090002551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090002552 catalytic residue [active] 281090002553 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 281090002554 substrate binding site [chemical binding]; other site 281090002555 active site 281090002556 catalytic residues [active] 281090002557 heterodimer interface [polypeptide binding]; other site 281090002558 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 281090002559 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 281090002560 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 281090002561 active site 281090002562 dimer interface [polypeptide binding]; other site 281090002563 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 281090002564 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 281090002565 active site 281090002566 FMN binding site [chemical binding]; other site 281090002567 substrate binding site [chemical binding]; other site 281090002568 3Fe-4S cluster binding site [ion binding]; other site 281090002569 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 281090002570 domain interface; other site 281090002571 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 281090002572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281090002573 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 281090002574 pyruvate kinase; Provisional; Region: PRK06247 281090002575 domain interfaces; other site 281090002576 active site 281090002577 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 281090002578 EamA-like transporter family; Region: EamA; pfam00892 281090002579 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 281090002580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090002581 active site 281090002582 phosphorylation site [posttranslational modification] 281090002583 intermolecular recognition site; other site 281090002584 dimerization interface [polypeptide binding]; other site 281090002585 ANTAR domain; Region: ANTAR; pfam03861 281090002586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 281090002587 CoenzymeA binding site [chemical binding]; other site 281090002588 subunit interaction site [polypeptide binding]; other site 281090002589 PHB binding site; other site 281090002590 DNA polymerase I; Provisional; Region: PRK05755 281090002591 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 281090002592 active site 281090002593 metal binding site 1 [ion binding]; metal-binding site 281090002594 putative 5' ssDNA interaction site; other site 281090002595 metal binding site 3; metal-binding site 281090002596 metal binding site 2 [ion binding]; metal-binding site 281090002597 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 281090002598 putative DNA binding site [nucleotide binding]; other site 281090002599 putative metal binding site [ion binding]; other site 281090002600 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 281090002601 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 281090002602 active site 281090002603 DNA binding site [nucleotide binding] 281090002604 catalytic site [active] 281090002605 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 281090002606 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 281090002607 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 281090002608 RNA binding site [nucleotide binding]; other site 281090002609 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 281090002610 RNA binding site [nucleotide binding]; other site 281090002611 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 281090002612 RNA binding site [nucleotide binding]; other site 281090002613 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 281090002614 RNA binding site [nucleotide binding]; other site 281090002615 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 281090002616 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 281090002617 CoA-binding site [chemical binding]; other site 281090002618 ATP-binding [chemical binding]; other site 281090002619 excinuclease ABC subunit B; Provisional; Region: PRK05298 281090002620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090002621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090002622 nucleotide binding region [chemical binding]; other site 281090002623 ATP-binding site [chemical binding]; other site 281090002624 Ultra-violet resistance protein B; Region: UvrB; pfam12344 281090002625 UvrB/uvrC motif; Region: UVR; pfam02151 281090002626 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 281090002627 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 281090002628 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 281090002629 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 281090002630 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 281090002631 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 281090002632 GIY-YIG motif/motif A; other site 281090002633 active site 281090002634 catalytic site [active] 281090002635 putative DNA binding site [nucleotide binding]; other site 281090002636 metal binding site [ion binding]; metal-binding site 281090002637 UvrB/uvrC motif; Region: UVR; pfam02151 281090002638 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 281090002639 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 281090002640 shikimate kinase; Reviewed; Region: aroK; PRK00131 281090002641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 281090002642 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 281090002643 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 281090002644 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 281090002645 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 281090002646 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 281090002647 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 281090002648 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 281090002649 Phosphoglycerate kinase; Region: PGK; pfam00162 281090002650 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 281090002651 substrate binding site [chemical binding]; other site 281090002652 hinge regions; other site 281090002653 ADP binding site [chemical binding]; other site 281090002654 catalytic site [active] 281090002655 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 281090002656 triosephosphate isomerase; Provisional; Region: PRK14565 281090002657 substrate binding site [chemical binding]; other site 281090002658 dimer interface [polypeptide binding]; other site 281090002659 catalytic triad [active] 281090002660 Preprotein translocase SecG subunit; Region: SecG; pfam03840 281090002661 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 281090002662 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 281090002663 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 281090002664 putative active site [active] 281090002665 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 281090002666 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 281090002667 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 281090002668 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 281090002669 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 281090002670 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 281090002671 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 281090002672 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 281090002673 putative active site [active] 281090002674 transaldolase; Provisional; Region: PRK03903 281090002675 catalytic residue [active] 281090002676 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 281090002677 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 281090002678 TPP-binding site [chemical binding]; other site 281090002679 dimer interface [polypeptide binding]; other site 281090002680 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 281090002681 PYR/PP interface [polypeptide binding]; other site 281090002682 dimer interface [polypeptide binding]; other site 281090002683 TPP binding site [chemical binding]; other site 281090002684 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281090002685 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 281090002686 UbiA prenyltransferase family; Region: UbiA; pfam01040 281090002687 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 281090002688 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 281090002689 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 281090002690 FeS assembly protein SufB; Region: sufB; TIGR01980 281090002691 FeS assembly protein SufD; Region: sufD; TIGR01981 281090002692 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 281090002693 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 281090002694 [2Fe-2S] cluster binding site [ion binding]; other site 281090002695 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 281090002696 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 281090002697 Walker A/P-loop; other site 281090002698 ATP binding site [chemical binding]; other site 281090002699 Q-loop/lid; other site 281090002700 ABC transporter signature motif; other site 281090002701 Walker B; other site 281090002702 D-loop; other site 281090002703 H-loop/switch region; other site 281090002704 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 281090002705 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281090002706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090002707 Walker A/P-loop; other site 281090002708 ATP binding site [chemical binding]; other site 281090002709 Q-loop/lid; other site 281090002710 ABC transporter signature motif; other site 281090002711 Walker B; other site 281090002712 D-loop; other site 281090002713 H-loop/switch region; other site 281090002714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281090002715 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 281090002716 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 281090002717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090002718 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 281090002719 NAD(P) binding site [chemical binding]; other site 281090002720 active site 281090002721 phosphoserine phosphatase SerB; Region: serB; TIGR00338 281090002722 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 281090002723 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 281090002724 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 281090002725 ligand binding site; other site 281090002726 oligomer interface; other site 281090002727 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 281090002728 dimer interface [polypeptide binding]; other site 281090002729 N-terminal domain interface [polypeptide binding]; other site 281090002730 sulfate 1 binding site; other site 281090002731 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281090002732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090002733 Walker A/P-loop; other site 281090002734 ATP binding site [chemical binding]; other site 281090002735 Q-loop/lid; other site 281090002736 ABC transporter signature motif; other site 281090002737 Walker B; other site 281090002738 D-loop; other site 281090002739 H-loop/switch region; other site 281090002740 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 281090002741 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 281090002742 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 281090002743 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 281090002744 active site 281090002745 catalytic site [active] 281090002746 substrate binding site [chemical binding]; other site 281090002747 trehalose synthase; Region: treS_nterm; TIGR02456 281090002748 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 281090002749 active site 281090002750 catalytic site [active] 281090002751 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 281090002752 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 281090002753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281090002754 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 281090002755 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 281090002756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281090002757 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281090002758 catalytic core [active] 281090002759 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 281090002760 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 281090002761 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 281090002762 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 281090002763 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 281090002764 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 281090002765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090002766 Walker A/P-loop; other site 281090002767 ATP binding site [chemical binding]; other site 281090002768 Q-loop/lid; other site 281090002769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090002770 ABC transporter signature motif; other site 281090002771 Walker B; other site 281090002772 D-loop; other site 281090002773 H-loop/switch region; other site 281090002774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090002775 Walker A/P-loop; other site 281090002776 ATP binding site [chemical binding]; other site 281090002777 Q-loop/lid; other site 281090002778 ABC transporter signature motif; other site 281090002779 Walker B; other site 281090002780 D-loop; other site 281090002781 H-loop/switch region; other site 281090002782 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 281090002783 active site 281090002784 catalytic triad [active] 281090002785 oxyanion hole [active] 281090002786 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 281090002787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090002788 ATP binding site [chemical binding]; other site 281090002789 putative Mg++ binding site [ion binding]; other site 281090002790 glutamate dehydrogenase; Provisional; Region: PRK09414 281090002791 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 281090002792 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 281090002793 NAD(P) binding pocket [chemical binding]; other site 281090002794 AMP nucleosidase; Provisional; Region: PRK07115 281090002795 hypothetical protein; Provisional; Region: PRK06541 281090002796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281090002797 inhibitor-cofactor binding pocket; inhibition site 281090002798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090002799 catalytic residue [active] 281090002800 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 281090002801 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 281090002802 putative DNA binding site [nucleotide binding]; other site 281090002803 putative Zn2+ binding site [ion binding]; other site 281090002804 AsnC family; Region: AsnC_trans_reg; pfam01037 281090002805 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 281090002806 NAD(P) binding site [chemical binding]; other site 281090002807 catalytic residues [active] 281090002808 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 281090002809 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 281090002810 tetrameric interface [polypeptide binding]; other site 281090002811 NAD binding site [chemical binding]; other site 281090002812 catalytic residues [active] 281090002813 substrate binding site [chemical binding]; other site 281090002814 transcription termination factor Rho; Provisional; Region: PRK12678 281090002815 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 281090002816 phosphopeptide binding site; other site 281090002817 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 281090002818 Protein phosphatase 2C; Region: PP2C; pfam00481 281090002819 active site 281090002820 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281090002821 Catalytic domain of Protein Kinases; Region: PKc; cd00180 281090002822 active site 281090002823 ATP binding site [chemical binding]; other site 281090002824 substrate binding site [chemical binding]; other site 281090002825 activation loop (A-loop); other site 281090002826 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 281090002827 Interdomain contacts; other site 281090002828 Cytokine receptor motif; other site 281090002829 MoxR-like ATPases [General function prediction only]; Region: COG0714 281090002830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090002831 Walker A motif; other site 281090002832 ATP binding site [chemical binding]; other site 281090002833 Walker B motif; other site 281090002834 arginine finger; other site 281090002835 Protein of unknown function DUF58; Region: DUF58; pfam01882 281090002836 Transglutaminase/protease-like homologues; Region: TGc; smart00460 281090002837 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 281090002838 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 281090002839 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 281090002840 hexamer interface [polypeptide binding]; other site 281090002841 ligand binding site [chemical binding]; other site 281090002842 putative active site [active] 281090002843 NAD(P) binding site [chemical binding]; other site 281090002844 L-asparaginase II; Region: Asparaginase_II; pfam06089 281090002845 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 281090002846 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281090002847 inhibitor-cofactor binding pocket; inhibition site 281090002848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090002849 catalytic residue [active] 281090002850 OsmC-like protein; Region: OsmC; cl00767 281090002851 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 281090002852 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 281090002853 putative acyl-acceptor binding pocket; other site 281090002854 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 281090002855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 281090002856 inhibitor-cofactor binding pocket; inhibition site 281090002857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090002858 catalytic residue [active] 281090002859 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 281090002860 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 281090002861 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 281090002862 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 281090002863 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 281090002864 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 281090002865 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 281090002866 active site 281090002867 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 281090002868 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 281090002869 putative substrate binding region [chemical binding]; other site 281090002870 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 281090002871 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 281090002872 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 281090002873 prolyl-tRNA synthetase; Provisional; Region: PRK09194 281090002874 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 281090002875 dimer interface [polypeptide binding]; other site 281090002876 motif 1; other site 281090002877 active site 281090002878 motif 2; other site 281090002879 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 281090002880 putative deacylase active site [active] 281090002881 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 281090002882 active site 281090002883 motif 3; other site 281090002884 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 281090002885 anticodon binding site; other site 281090002886 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 281090002887 Uncharacterized conserved protein [Function unknown]; Region: COG4850 281090002888 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 281090002889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281090002890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090002891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090002892 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 281090002893 Walker A/P-loop; other site 281090002894 ATP binding site [chemical binding]; other site 281090002895 Q-loop/lid; other site 281090002896 ABC transporter signature motif; other site 281090002897 Walker B; other site 281090002898 D-loop; other site 281090002899 H-loop/switch region; other site 281090002900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 281090002901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090002902 dimer interface [polypeptide binding]; other site 281090002903 conserved gate region; other site 281090002904 putative PBP binding loops; other site 281090002905 ABC-ATPase subunit interface; other site 281090002906 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 281090002907 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 281090002908 Penicillinase repressor; Region: Pencillinase_R; pfam03965 281090002909 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 281090002910 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 281090002911 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 281090002912 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 281090002913 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281090002914 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 281090002915 Walker A/P-loop; other site 281090002916 ATP binding site [chemical binding]; other site 281090002917 Q-loop/lid; other site 281090002918 ABC transporter signature motif; other site 281090002919 Walker B; other site 281090002920 D-loop; other site 281090002921 H-loop/switch region; other site 281090002922 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 281090002923 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 281090002924 Walker A/P-loop; other site 281090002925 ATP binding site [chemical binding]; other site 281090002926 Q-loop/lid; other site 281090002927 ABC transporter signature motif; other site 281090002928 Walker B; other site 281090002929 D-loop; other site 281090002930 H-loop/switch region; other site 281090002931 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 281090002932 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 281090002933 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 281090002934 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 281090002935 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 281090002936 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 281090002937 HIGH motif; other site 281090002938 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 281090002939 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 281090002940 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 281090002941 active site 281090002942 KMSKS motif; other site 281090002943 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 281090002944 tRNA binding surface [nucleotide binding]; other site 281090002945 Prephenate dehydratase; Region: PDT; pfam00800 281090002946 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 281090002947 rRNA interaction site [nucleotide binding]; other site 281090002948 S8 interaction site; other site 281090002949 putative laminin-1 binding site; other site 281090002950 elongation factor Ts; Provisional; Region: tsf; PRK09377 281090002951 UBA/TS-N domain; Region: UBA; pfam00627 281090002952 Elongation factor TS; Region: EF_TS; pfam00889 281090002953 Elongation factor TS; Region: EF_TS; pfam00889 281090002954 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 281090002955 putative nucleotide binding site [chemical binding]; other site 281090002956 uridine monophosphate binding site [chemical binding]; other site 281090002957 homohexameric interface [polypeptide binding]; other site 281090002958 ribosome recycling factor; Reviewed; Region: frr; PRK00083 281090002959 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 281090002960 hinge region; other site 281090002961 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 281090002962 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 281090002963 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 281090002964 DivIVA domain; Region: DivI1A_domain; TIGR03544 281090002965 DivIVA domain; Region: DivI1A_domain; TIGR03544 281090002966 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 281090002967 N-acetyl-D-glucosamine binding site [chemical binding]; other site 281090002968 catalytic residue [active] 281090002969 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281090002970 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281090002971 DivIVA protein; Region: DivIVA; pfam05103 281090002972 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 281090002973 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 281090002974 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 281090002975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 281090002976 TPR motif; other site 281090002977 binding surface 281090002978 glycogen branching enzyme; Provisional; Region: PRK05402 281090002979 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 281090002980 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 281090002981 active site 281090002982 catalytic site [active] 281090002983 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 281090002984 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 281090002985 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 281090002986 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 281090002987 active site 281090002988 homodimer interface [polypeptide binding]; other site 281090002989 catalytic site [active] 281090002990 acceptor binding site [chemical binding]; other site 281090002991 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 281090002992 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 281090002993 dimer interface [polypeptide binding]; other site 281090002994 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 281090002995 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 281090002996 dimer interface [polypeptide binding]; other site 281090002997 catalytic triad [active] 281090002998 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 281090002999 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 281090003000 dimer interface [polypeptide binding]; other site 281090003001 TPP-binding site [chemical binding]; other site 281090003002 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 281090003003 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 281090003004 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 281090003005 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 281090003006 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 281090003007 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 281090003008 dimer interface [polypeptide binding]; other site 281090003009 active site 281090003010 CoA binding pocket [chemical binding]; other site 281090003011 acyl carrier protein; Provisional; Region: acpP; PRK00982 281090003012 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 281090003013 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 281090003014 dimer interface [polypeptide binding]; other site 281090003015 active site 281090003016 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 281090003017 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 281090003018 active site 281090003019 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 281090003020 catalytic triad [active] 281090003021 dimer interface [polypeptide binding]; other site 281090003022 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 281090003023 active site 1 [active] 281090003024 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 281090003025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090003026 Walker A/P-loop; other site 281090003027 ATP binding site [chemical binding]; other site 281090003028 Q-loop/lid; other site 281090003029 ABC transporter signature motif; other site 281090003030 Walker B; other site 281090003031 D-loop; other site 281090003032 H-loop/switch region; other site 281090003033 ABC transporter; Region: ABC_tran_2; pfam12848 281090003034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281090003035 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 281090003036 ssDNA binding site [nucleotide binding]; other site 281090003037 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 281090003038 dimer interface [polypeptide binding]; other site 281090003039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281090003040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281090003041 active site 281090003042 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 281090003043 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 281090003044 homodimer interface [polypeptide binding]; other site 281090003045 NAD binding pocket [chemical binding]; other site 281090003046 ATP binding pocket [chemical binding]; other site 281090003047 Mg binding site [ion binding]; other site 281090003048 active-site loop [active] 281090003049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090003050 putative DNA binding site [nucleotide binding]; other site 281090003051 putative Zn2+ binding site [ion binding]; other site 281090003052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 281090003053 dimerization interface [polypeptide binding]; other site 281090003054 H+ Antiporter protein; Region: 2A0121; TIGR00900 281090003055 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 281090003056 putative active site [active] 281090003057 catalytic site [active] 281090003058 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 281090003059 Transposase; Region: HTH_Tnp_1; cl17663 281090003060 Transposase; Region: DEDD_Tnp_IS110; pfam01548 281090003061 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 281090003062 Integrase core domain; Region: rve_3; cl15866 281090003063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281090003064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 281090003065 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 281090003066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090003067 motif II; other site 281090003068 Transposase, Mutator family; Region: Transposase_mut; pfam00872 281090003069 Transposase, Mutator family; Region: Transposase_mut; pfam00872 281090003070 MULE transposase domain; Region: MULE; pfam10551 281090003071 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 281090003072 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281090003073 active site 281090003074 Int/Topo IB signature motif; other site 281090003075 catalytic residues [active] 281090003076 DNA binding site [nucleotide binding] 281090003077 Helix-turn-helix domain; Region: HTH_17; pfam12728 281090003078 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 281090003079 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 281090003080 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 281090003081 HIGH motif; other site 281090003082 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 281090003083 active site 281090003084 KMSKS motif; other site 281090003085 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 281090003086 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 281090003087 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 281090003088 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 281090003089 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 281090003090 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 281090003091 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 281090003092 homodimer interface [polypeptide binding]; other site 281090003093 substrate-cofactor binding pocket; other site 281090003094 catalytic residue [active] 281090003095 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 281090003096 tartrate dehydrogenase; Region: TTC; TIGR02089 281090003097 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 281090003098 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 281090003099 ligand binding site [chemical binding]; other site 281090003100 NAD binding site [chemical binding]; other site 281090003101 dimerization interface [polypeptide binding]; other site 281090003102 catalytic site [active] 281090003103 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 281090003104 putative L-serine binding site [chemical binding]; other site 281090003105 CutC family; Region: CutC; cl01218 281090003106 ketol-acid reductoisomerase; Provisional; Region: PRK05479 281090003107 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 281090003108 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 281090003109 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 281090003110 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 281090003111 putative valine binding site [chemical binding]; other site 281090003112 dimer interface [polypeptide binding]; other site 281090003113 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 281090003114 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 281090003115 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 281090003116 PYR/PP interface [polypeptide binding]; other site 281090003117 dimer interface [polypeptide binding]; other site 281090003118 TPP binding site [chemical binding]; other site 281090003119 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 281090003120 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 281090003121 TPP-binding site [chemical binding]; other site 281090003122 dimer interface [polypeptide binding]; other site 281090003123 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 281090003124 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 281090003125 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 281090003126 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 281090003127 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 281090003128 active site 281090003129 homotetramer interface [polypeptide binding]; other site 281090003130 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 281090003131 active site 281090003132 catalytic triad [active] 281090003133 oxyanion hole [active] 281090003134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 281090003135 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 281090003136 transmembrane helices; other site 281090003137 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 281090003138 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 281090003139 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 281090003140 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 281090003141 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 281090003142 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090003143 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281090003144 nucleotide binding site [chemical binding]; other site 281090003145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 281090003146 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 281090003147 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 281090003148 active site 281090003149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090003150 dimerization interface [polypeptide binding]; other site 281090003151 putative DNA binding site [nucleotide binding]; other site 281090003152 putative Zn2+ binding site [ion binding]; other site 281090003153 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 281090003154 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 281090003155 Walker A/P-loop; other site 281090003156 ATP binding site [chemical binding]; other site 281090003157 Q-loop/lid; other site 281090003158 ABC transporter signature motif; other site 281090003159 Walker B; other site 281090003160 D-loop; other site 281090003161 H-loop/switch region; other site 281090003162 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 281090003163 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 281090003164 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 281090003165 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 281090003166 active site 281090003167 purine riboside binding site [chemical binding]; other site 281090003168 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 281090003169 helicase 45; Provisional; Region: PTZ00424 281090003170 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 281090003171 ATP binding site [chemical binding]; other site 281090003172 Mg++ binding site [ion binding]; other site 281090003173 motif III; other site 281090003174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090003175 nucleotide binding region [chemical binding]; other site 281090003176 ATP-binding site [chemical binding]; other site 281090003177 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 281090003178 putative RNA binding site [nucleotide binding]; other site 281090003179 Transposase; Region: HTH_Tnp_1; cl17663 281090003180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 281090003181 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 281090003182 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 281090003183 active site 281090003184 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 281090003185 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 281090003186 SmpB-tmRNA interface; other site 281090003187 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 281090003188 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 281090003189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090003190 Walker A/P-loop; other site 281090003191 ATP binding site [chemical binding]; other site 281090003192 Q-loop/lid; other site 281090003193 ABC transporter signature motif; other site 281090003194 Walker B; other site 281090003195 D-loop; other site 281090003196 H-loop/switch region; other site 281090003197 peptide chain release factor 2; Validated; Region: prfB; PRK00578 281090003198 This domain is found in peptide chain release factors; Region: PCRF; smart00937 281090003199 RF-1 domain; Region: RF-1; pfam00472 281090003200 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 281090003201 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 281090003202 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 281090003203 active site 281090003204 dimerization interface [polypeptide binding]; other site 281090003205 ribonuclease PH; Reviewed; Region: rph; PRK00173 281090003206 Ribonuclease PH; Region: RNase_PH_bact; cd11362 281090003207 hexamer interface [polypeptide binding]; other site 281090003208 active site 281090003209 glutamate racemase; Provisional; Region: PRK00865 281090003210 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 281090003211 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 281090003212 active site 281090003213 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 281090003214 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 281090003215 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 281090003216 Walker A/P-loop; other site 281090003217 ATP binding site [chemical binding]; other site 281090003218 Q-loop/lid; other site 281090003219 ABC transporter signature motif; other site 281090003220 Walker B; other site 281090003221 D-loop; other site 281090003222 H-loop/switch region; other site 281090003223 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 281090003224 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 281090003225 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 281090003226 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281090003227 Walker A/P-loop; other site 281090003228 ATP binding site [chemical binding]; other site 281090003229 Q-loop/lid; other site 281090003230 ABC transporter signature motif; other site 281090003231 Walker B; other site 281090003232 D-loop; other site 281090003233 H-loop/switch region; other site 281090003234 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 281090003235 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 281090003236 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 281090003237 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 281090003238 Ligand binding site; other site 281090003239 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 281090003240 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 281090003241 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281090003242 active site 281090003243 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090003244 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090003245 Integrase core domain; Region: rve; pfam00665 281090003246 Transposase; Region: DEDD_Tnp_IS110; pfam01548 281090003247 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 281090003248 Transposase, Mutator family; Region: Transposase_mut; pfam00872 281090003249 AAA ATPase domain; Region: AAA_16; pfam13191 281090003250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 281090003251 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 281090003252 DNA-binding interface [nucleotide binding]; DNA binding site 281090003253 Integrase core domain; Region: rve; pfam00665 281090003254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090003255 Walker A motif; other site 281090003256 ATP binding site [chemical binding]; other site 281090003257 Walker B motif; other site 281090003258 Integrase core domain; Region: rve; pfam00665 281090003259 Integrase core domain; Region: rve_3; cl15866 281090003260 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 281090003261 CAAX protease self-immunity; Region: Abi; pfam02517 281090003262 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 281090003263 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 281090003264 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 281090003265 DXD motif; other site 281090003266 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 281090003267 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 281090003268 DXD motif; other site 281090003269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281090003270 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 281090003271 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 281090003272 homodimer interface [polypeptide binding]; other site 281090003273 active site 281090003274 Transposase; Region: HTH_Tnp_1; cl17663 281090003275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090003276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090003277 DNA binding residues [nucleotide binding] 281090003278 dimerization interface [polypeptide binding]; other site 281090003279 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 281090003280 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 281090003281 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 281090003282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090003283 dimer interface [polypeptide binding]; other site 281090003284 conserved gate region; other site 281090003285 putative PBP binding loops; other site 281090003286 ABC-ATPase subunit interface; other site 281090003287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 281090003288 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 281090003289 putative catalytic site [active] 281090003290 putative phosphate binding site [ion binding]; other site 281090003291 putative metal binding site [ion binding]; other site 281090003292 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281090003293 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281090003294 DNA binding site [nucleotide binding] 281090003295 domain linker motif; other site 281090003296 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 281090003297 dimerization interface [polypeptide binding]; other site 281090003298 ligand binding site [chemical binding]; other site 281090003299 Lsr2; Region: Lsr2; pfam11774 281090003300 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 281090003301 catalytic site [active] 281090003302 putative active site [active] 281090003303 putative substrate binding site [chemical binding]; other site 281090003304 dimer interface [polypeptide binding]; other site 281090003305 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 281090003306 active site 281090003307 catalytic triad [active] 281090003308 oxyanion hole [active] 281090003309 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281090003310 catalytic residues [active] 281090003311 F-actin binding; Region: F_actin_bind; cl07494 281090003312 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 281090003313 N-acetyl-D-glucosamine binding site [chemical binding]; other site 281090003314 catalytic residue [active] 281090003315 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 281090003316 hypothetical protein; Provisional; Region: PRK06547 281090003317 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 281090003318 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281090003319 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281090003320 Walker A/P-loop; other site 281090003321 ATP binding site [chemical binding]; other site 281090003322 Q-loop/lid; other site 281090003323 ABC transporter signature motif; other site 281090003324 Walker B; other site 281090003325 D-loop; other site 281090003326 H-loop/switch region; other site 281090003327 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281090003328 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 281090003329 Walker A/P-loop; other site 281090003330 ATP binding site [chemical binding]; other site 281090003331 Q-loop/lid; other site 281090003332 ABC transporter signature motif; other site 281090003333 Walker B; other site 281090003334 D-loop; other site 281090003335 H-loop/switch region; other site 281090003336 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 281090003337 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 281090003338 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 281090003339 putative catalytic site [active] 281090003340 putative metal binding site [ion binding]; other site 281090003341 putative phosphate binding site [ion binding]; other site 281090003342 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 281090003343 active site 281090003344 DNA polymerase IV; Validated; Region: PRK02406 281090003345 DNA binding site [nucleotide binding] 281090003346 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 281090003347 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 281090003348 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 281090003349 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 281090003350 GatB domain; Region: GatB_Yqey; smart00845 281090003351 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 281090003352 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 281090003353 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 281090003354 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 281090003355 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 281090003356 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 281090003357 nucleotide binding pocket [chemical binding]; other site 281090003358 K-X-D-G motif; other site 281090003359 catalytic site [active] 281090003360 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 281090003361 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 281090003362 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 281090003363 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 281090003364 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 281090003365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281090003366 catalytic residue [active] 281090003367 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 281090003368 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 281090003369 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090003370 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090003371 Integrase core domain; Region: rve; pfam00665 281090003372 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 281090003373 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281090003374 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281090003375 acyl-activating enzyme (AAE) consensus motif; other site 281090003376 acyl-activating enzyme (AAE) consensus motif; other site 281090003377 AMP binding site [chemical binding]; other site 281090003378 active site 281090003379 CoA binding site [chemical binding]; other site 281090003380 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 281090003381 putative dimer interface [polypeptide binding]; other site 281090003382 ligand binding site [chemical binding]; other site 281090003383 Zn binding site [ion binding]; other site 281090003384 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 281090003385 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 281090003386 catalytic residue [active] 281090003387 putative FPP diphosphate binding site; other site 281090003388 putative FPP binding hydrophobic cleft; other site 281090003389 dimer interface [polypeptide binding]; other site 281090003390 putative IPP diphosphate binding site; other site 281090003391 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 281090003392 Recombination protein O N terminal; Region: RecO_N; pfam11967 281090003393 Recombination protein O C terminal; Region: RecO_C; pfam02565 281090003394 Predicted membrane protein [Function unknown]; Region: COG2860 281090003395 UPF0126 domain; Region: UPF0126; pfam03458 281090003396 2-isopropylmalate synthase; Validated; Region: PRK03739 281090003397 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 281090003398 active site 281090003399 catalytic residues [active] 281090003400 metal binding site [ion binding]; metal-binding site 281090003401 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 281090003402 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 281090003403 Putative esterase; Region: Esterase; pfam00756 281090003404 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281090003405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281090003406 Walker A/P-loop; other site 281090003407 ATP binding site [chemical binding]; other site 281090003408 Q-loop/lid; other site 281090003409 ABC transporter signature motif; other site 281090003410 Walker B; other site 281090003411 D-loop; other site 281090003412 H-loop/switch region; other site 281090003413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090003414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090003415 active site 281090003416 phosphorylation site [posttranslational modification] 281090003417 intermolecular recognition site; other site 281090003418 dimerization interface [polypeptide binding]; other site 281090003419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090003420 DNA binding residues [nucleotide binding] 281090003421 dimerization interface [polypeptide binding]; other site 281090003422 Histidine kinase; Region: HisKA_3; pfam07730 281090003423 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 281090003424 GTPase Era; Reviewed; Region: era; PRK00089 281090003425 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 281090003426 G1 box; other site 281090003427 GTP/Mg2+ binding site [chemical binding]; other site 281090003428 Switch I region; other site 281090003429 G2 box; other site 281090003430 Switch II region; other site 281090003431 G3 box; other site 281090003432 G4 box; other site 281090003433 G5 box; other site 281090003434 KH domain; Region: KH_2; pfam07650 281090003435 Domain of unknown function DUF21; Region: DUF21; pfam01595 281090003436 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281090003437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281090003438 Transporter associated domain; Region: CorC_HlyC; smart01091 281090003439 metal-binding heat shock protein; Provisional; Region: PRK00016 281090003440 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 281090003441 PhoH-like protein; Region: PhoH; pfam02562 281090003442 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 281090003443 nucleotide binding site/active site [active] 281090003444 HIT family signature motif; other site 281090003445 catalytic residue [active] 281090003446 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 281090003447 chaperone protein DnaJ; Provisional; Region: PRK14278 281090003448 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 281090003449 HSP70 interaction site [polypeptide binding]; other site 281090003450 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 281090003451 Zn binding sites [ion binding]; other site 281090003452 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 281090003453 dimer interface [polypeptide binding]; other site 281090003454 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 281090003455 Tic20-like protein; Region: Tic20; pfam09685 281090003456 coproporphyrinogen III oxidase; Validated; Region: PRK05628 281090003457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281090003458 FeS/SAM binding site; other site 281090003459 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 281090003460 GTP-binding protein LepA; Provisional; Region: PRK05433 281090003461 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 281090003462 G1 box; other site 281090003463 putative GEF interaction site [polypeptide binding]; other site 281090003464 GTP/Mg2+ binding site [chemical binding]; other site 281090003465 Switch I region; other site 281090003466 G2 box; other site 281090003467 G3 box; other site 281090003468 Switch II region; other site 281090003469 G4 box; other site 281090003470 G5 box; other site 281090003471 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 281090003472 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 281090003473 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 281090003474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090003475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 281090003476 NAD(P) binding site [chemical binding]; other site 281090003477 active site 281090003478 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 281090003479 hypothetical protein; Reviewed; Region: PRK07914 281090003480 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 281090003481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090003482 putative substrate translocation pore; other site 281090003483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090003484 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 281090003485 DNA protecting protein DprA; Region: dprA; TIGR00732 281090003486 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 281090003487 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 281090003488 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 281090003489 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 281090003490 hypothetical protein; Reviewed; Region: PRK12497 281090003491 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 281090003492 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 281090003493 RNA/DNA hybrid binding site [nucleotide binding]; other site 281090003494 active site 281090003495 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 281090003496 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 281090003497 active site 281090003498 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 281090003499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090003500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281090003501 putative substrate translocation pore; other site 281090003502 FCD domain; Region: FCD; pfam07729 281090003503 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281090003504 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 281090003505 RimM N-terminal domain; Region: RimM; pfam01782 281090003506 hypothetical protein; Provisional; Region: PRK02821 281090003507 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 281090003508 G-X-X-G motif; other site 281090003509 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 281090003510 carboxylate-amine ligase; Provisional; Region: PRK13517 281090003511 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 281090003512 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 281090003513 active site 281090003514 catalytic triad [active] 281090003515 oxyanion hole [active] 281090003516 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090003517 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090003518 Integrase core domain; Region: rve; pfam00665 281090003519 signal recognition particle protein; Provisional; Region: PRK10867 281090003520 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 281090003521 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 281090003522 P loop; other site 281090003523 GTP binding site [chemical binding]; other site 281090003524 Signal peptide binding domain; Region: SRP_SPB; pfam02978 281090003525 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 281090003526 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 281090003527 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 281090003528 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 281090003529 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 281090003530 AAA domain; Region: AAA_23; pfam13476 281090003531 Walker A/P-loop; other site 281090003532 ATP binding site [chemical binding]; other site 281090003533 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 281090003534 ABC transporter signature motif; other site 281090003535 Walker B; other site 281090003536 D-loop; other site 281090003537 H-loop/switch region; other site 281090003538 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 281090003539 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 281090003540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090003541 catalytic residue [active] 281090003542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090003543 ABC transporter signature motif; other site 281090003544 Walker B; other site 281090003545 D-loop; other site 281090003546 H-loop/switch region; other site 281090003547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090003548 Walker A/P-loop; other site 281090003549 ATP binding site [chemical binding]; other site 281090003550 Q-loop/lid; other site 281090003551 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 281090003552 TM-ABC transporter signature motif; other site 281090003553 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 281090003554 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 281090003555 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 281090003556 Walker A/P-loop; other site 281090003557 ATP binding site [chemical binding]; other site 281090003558 Q-loop/lid; other site 281090003559 ABC transporter signature motif; other site 281090003560 Walker B; other site 281090003561 D-loop; other site 281090003562 H-loop/switch region; other site 281090003563 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 281090003564 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 281090003565 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 281090003566 D-pathway; other site 281090003567 Putative ubiquinol binding site [chemical binding]; other site 281090003568 Low-spin heme (heme b) binding site [chemical binding]; other site 281090003569 Putative water exit pathway; other site 281090003570 Binuclear center (heme o3/CuB) [ion binding]; other site 281090003571 K-pathway; other site 281090003572 Putative proton exit pathway; other site 281090003573 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 281090003574 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 281090003575 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 281090003576 hypothetical protein; Provisional; Region: PRK07907 281090003577 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 281090003578 active site 281090003579 metal binding site [ion binding]; metal-binding site 281090003580 dimer interface [polypeptide binding]; other site 281090003581 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 281090003582 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 281090003583 RNA/DNA hybrid binding site [nucleotide binding]; other site 281090003584 active site 281090003585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 281090003586 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 281090003587 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 281090003588 quinone interaction residues [chemical binding]; other site 281090003589 active site 281090003590 catalytic residues [active] 281090003591 FMN binding site [chemical binding]; other site 281090003592 substrate binding site [chemical binding]; other site 281090003593 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 281090003594 ATP cone domain; Region: ATP-cone; pfam03477 281090003595 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 281090003596 histidinol dehydrogenase; Region: hisD; TIGR00069 281090003597 NAD binding site [chemical binding]; other site 281090003598 dimerization interface [polypeptide binding]; other site 281090003599 product binding site; other site 281090003600 substrate binding site [chemical binding]; other site 281090003601 zinc binding site [ion binding]; other site 281090003602 catalytic residues [active] 281090003603 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 281090003604 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 281090003605 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 281090003606 active site 281090003607 PHP Thumb interface [polypeptide binding]; other site 281090003608 metal binding site [ion binding]; metal-binding site 281090003609 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 281090003610 generic binding surface II; other site 281090003611 generic binding surface I; other site 281090003612 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 281090003613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 281090003614 RNA binding surface [nucleotide binding]; other site 281090003615 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 281090003616 active site 281090003617 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 281090003618 DivIVA protein; Region: DivIVA; pfam05103 281090003619 Protein of unknown function (DUF552); Region: DUF552; pfam04472 281090003620 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 281090003621 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281090003622 catalytic residue [active] 281090003623 cell division protein FtsZ; Validated; Region: PRK09330 281090003624 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 281090003625 nucleotide binding site [chemical binding]; other site 281090003626 SulA interaction site; other site 281090003627 cell division protein FtsQ; Provisional; Region: PRK05529 281090003628 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 281090003629 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 281090003630 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281090003631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281090003632 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281090003633 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 281090003634 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 281090003635 homodimer interface [polypeptide binding]; other site 281090003636 active site 281090003637 cell division protein FtsW; Region: ftsW; TIGR02614 281090003638 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 281090003639 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 281090003640 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281090003641 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281090003642 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 281090003643 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 281090003644 Mg++ binding site [ion binding]; other site 281090003645 putative catalytic motif [active] 281090003646 putative substrate binding site [chemical binding]; other site 281090003647 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 281090003648 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 281090003649 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281090003650 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281090003651 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 281090003652 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 281090003653 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 281090003654 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 281090003655 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 281090003656 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 281090003657 MraW methylase family; Region: Methyltransf_5; cl17771 281090003658 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 281090003659 cell division protein MraZ; Reviewed; Region: PRK00326 281090003660 MraZ protein; Region: MraZ; pfam02381 281090003661 MraZ protein; Region: MraZ; pfam02381 281090003662 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 281090003663 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 281090003664 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 281090003665 substrate binding pocket [chemical binding]; other site 281090003666 chain length determination region; other site 281090003667 substrate-Mg2+ binding site; other site 281090003668 catalytic residues [active] 281090003669 aspartate-rich region 1; other site 281090003670 active site lid residues [active] 281090003671 aspartate-rich region 2; other site 281090003672 Helix-turn-helix domain; Region: HTH_17; cl17695 281090003673 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281090003674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281090003675 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281090003676 Catalytic domain of Protein Kinases; Region: PKc; cd00180 281090003677 active site 281090003678 ATP binding site [chemical binding]; other site 281090003679 substrate binding site [chemical binding]; other site 281090003680 activation loop (A-loop); other site 281090003681 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090003682 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090003683 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 281090003684 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 281090003685 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 281090003686 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 281090003687 putative acyl-acceptor binding pocket; other site 281090003688 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 281090003689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 281090003690 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 281090003691 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 281090003692 acyl-activating enzyme (AAE) consensus motif; other site 281090003693 putative AMP binding site [chemical binding]; other site 281090003694 putative active site [active] 281090003695 putative CoA binding site [chemical binding]; other site 281090003696 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 281090003697 active site 281090003698 catalytic residues [active] 281090003699 metal binding site [ion binding]; metal-binding site 281090003700 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 281090003701 pyruvate carboxylase; Reviewed; Region: PRK12999 281090003702 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 281090003703 ATP-grasp domain; Region: ATP-grasp_4; cl17255 281090003704 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 281090003705 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 281090003706 active site 281090003707 catalytic residues [active] 281090003708 metal binding site [ion binding]; metal-binding site 281090003709 homodimer binding site [polypeptide binding]; other site 281090003710 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 281090003711 carboxyltransferase (CT) interaction site; other site 281090003712 biotinylation site [posttranslational modification]; other site 281090003713 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 281090003714 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 281090003715 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 281090003716 Magnesium ion binding site [ion binding]; other site 281090003717 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 281090003718 DNA binding residues [nucleotide binding] 281090003719 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 281090003720 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 281090003721 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 281090003722 DNA binding residues [nucleotide binding] 281090003723 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 281090003724 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 281090003725 phosphopeptide binding site; other site 281090003726 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 281090003727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 281090003728 RNA binding surface [nucleotide binding]; other site 281090003729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 281090003730 HSP70 interaction site [polypeptide binding]; other site 281090003731 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 281090003732 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 281090003733 prenyltransferase; Reviewed; Region: ubiA; PRK13105 281090003734 UbiA prenyltransferase family; Region: UbiA; pfam01040 281090003735 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 281090003736 phytoene desaturase; Region: crtI_fam; TIGR02734 281090003737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 281090003738 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 281090003739 substrate binding pocket [chemical binding]; other site 281090003740 substrate-Mg2+ binding site; other site 281090003741 aspartate-rich region 1; other site 281090003742 aspartate-rich region 2; other site 281090003743 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 281090003744 substrate binding pocket [chemical binding]; other site 281090003745 chain length determination region; other site 281090003746 substrate-Mg2+ binding site; other site 281090003747 catalytic residues [active] 281090003748 aspartate-rich region 1; other site 281090003749 active site lid residues [active] 281090003750 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 281090003751 aspartate-rich region 2; other site 281090003752 MarR family; Region: MarR; pfam01047 281090003753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090003754 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 281090003755 NAD(P) binding site [chemical binding]; other site 281090003756 active site 281090003757 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 281090003758 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 281090003759 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 281090003760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090003761 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 281090003762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281090003763 DNA binding residues [nucleotide binding] 281090003764 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 281090003765 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 281090003766 putative DNA binding site [nucleotide binding]; other site 281090003767 putative homodimer interface [polypeptide binding]; other site 281090003768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090003769 dimer interface [polypeptide binding]; other site 281090003770 conserved gate region; other site 281090003771 ABC-ATPase subunit interface; other site 281090003772 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 281090003773 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 281090003774 Walker A/P-loop; other site 281090003775 ATP binding site [chemical binding]; other site 281090003776 Q-loop/lid; other site 281090003777 ABC transporter signature motif; other site 281090003778 Walker B; other site 281090003779 D-loop; other site 281090003780 H-loop/switch region; other site 281090003781 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 281090003782 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 281090003783 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 281090003784 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 281090003785 RNase_H superfamily; Region: RNase_H_2; pfam13482 281090003786 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 281090003787 AAA domain; Region: AAA_12; pfam13087 281090003788 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090003789 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090003790 Integrase core domain; Region: rve; pfam00665 281090003791 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 281090003792 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 281090003793 catalytic residues [active] 281090003794 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 281090003795 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 281090003796 putative active site [active] 281090003797 oxyanion strand; other site 281090003798 catalytic triad [active] 281090003799 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 281090003800 putative active site pocket [active] 281090003801 4-fold oligomerization interface [polypeptide binding]; other site 281090003802 metal binding residues [ion binding]; metal-binding site 281090003803 3-fold/trimer interface [polypeptide binding]; other site 281090003804 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 281090003805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281090003806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090003807 homodimer interface [polypeptide binding]; other site 281090003808 catalytic residue [active] 281090003809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 281090003810 LexA repressor; Validated; Region: PRK00215 281090003811 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 281090003812 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 281090003813 Catalytic site [active] 281090003814 Transcriptional regulators [Transcription]; Region: FadR; COG2186 281090003815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090003816 DNA-binding site [nucleotide binding]; DNA binding site 281090003817 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 281090003818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090003819 putative substrate translocation pore; other site 281090003820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281090003821 GTPases [General function prediction only]; Region: HflX; COG2262 281090003822 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 281090003823 HflX GTPase family; Region: HflX; cd01878 281090003824 G1 box; other site 281090003825 GTP/Mg2+ binding site [chemical binding]; other site 281090003826 Switch I region; other site 281090003827 G2 box; other site 281090003828 G3 box; other site 281090003829 Switch II region; other site 281090003830 G4 box; other site 281090003831 G5 box; other site 281090003832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090003833 S-adenosylmethionine binding site [chemical binding]; other site 281090003834 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 281090003835 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 281090003836 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 281090003837 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 281090003838 IPP transferase; Region: IPPT; pfam01715 281090003839 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 281090003840 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 281090003841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 281090003842 FeS/SAM binding site; other site 281090003843 recombination regulator RecX; Reviewed; Region: recX; PRK00117 281090003844 recombinase A; Provisional; Region: recA; PRK09354 281090003845 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 281090003846 hexamer interface [polypeptide binding]; other site 281090003847 Walker A motif; other site 281090003848 ATP binding site [chemical binding]; other site 281090003849 Walker B motif; other site 281090003850 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 281090003851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090003852 non-specific DNA binding site [nucleotide binding]; other site 281090003853 salt bridge; other site 281090003854 sequence-specific DNA binding site [nucleotide binding]; other site 281090003855 Competence-damaged protein; Region: CinA; pfam02464 281090003856 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 281090003857 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 281090003858 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 281090003859 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 281090003860 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 281090003861 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 281090003862 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 281090003863 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 281090003864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090003865 TIGR01777 family protein; Region: yfcH 281090003866 NAD(P) binding site [chemical binding]; other site 281090003867 active site 281090003868 dihydrodipicolinate reductase; Provisional; Region: PRK00048 281090003869 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 281090003870 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 281090003871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281090003872 catalytic core [active] 281090003873 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 281090003874 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 281090003875 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 281090003876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281090003877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090003878 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281090003879 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 281090003880 active site 281090003881 catalytic tetrad [active] 281090003882 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 281090003883 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 281090003884 dimer interface [polypeptide binding]; other site 281090003885 active site 281090003886 citrylCoA binding site [chemical binding]; other site 281090003887 NADH binding [chemical binding]; other site 281090003888 cationic pore residues; other site 281090003889 oxalacetate/citrate binding site [chemical binding]; other site 281090003890 coenzyme A binding site [chemical binding]; other site 281090003891 catalytic triad [active] 281090003892 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 281090003893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281090003894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090003895 homodimer interface [polypeptide binding]; other site 281090003896 catalytic residue [active] 281090003897 Ferredoxin [Energy production and conversion]; Region: COG1146 281090003898 4Fe-4S binding domain; Region: Fer4; pfam00037 281090003899 Iron permease FTR1 family; Region: FTR1; cl00475 281090003900 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 281090003901 Imelysin; Region: Peptidase_M75; pfam09375 281090003902 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 281090003903 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 281090003904 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 281090003905 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 281090003906 G1 box; other site 281090003907 GTP/Mg2+ binding site [chemical binding]; other site 281090003908 G2 box; other site 281090003909 Switch I region; other site 281090003910 G3 box; other site 281090003911 Switch II region; other site 281090003912 G4 box; other site 281090003913 G5 box; other site 281090003914 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 281090003915 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 281090003916 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281090003917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 281090003918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090003919 dimer interface [polypeptide binding]; other site 281090003920 conserved gate region; other site 281090003921 putative PBP binding loops; other site 281090003922 ABC-ATPase subunit interface; other site 281090003923 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 281090003924 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 281090003925 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 281090003926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090003927 Walker A/P-loop; other site 281090003928 ATP binding site [chemical binding]; other site 281090003929 Q-loop/lid; other site 281090003930 ABC transporter signature motif; other site 281090003931 Walker B; other site 281090003932 D-loop; other site 281090003933 H-loop/switch region; other site 281090003934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 281090003935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090003936 Walker A/P-loop; other site 281090003937 ATP binding site [chemical binding]; other site 281090003938 Q-loop/lid; other site 281090003939 ABC transporter signature motif; other site 281090003940 Walker B; other site 281090003941 D-loop; other site 281090003942 H-loop/switch region; other site 281090003943 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281090003944 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 281090003945 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 281090003946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090003947 dimer interface [polypeptide binding]; other site 281090003948 conserved gate region; other site 281090003949 putative PBP binding loops; other site 281090003950 ABC-ATPase subunit interface; other site 281090003951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281090003952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281090003953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090003954 dimer interface [polypeptide binding]; other site 281090003955 ABC-ATPase subunit interface; other site 281090003956 putative PBP binding loops; other site 281090003957 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 281090003958 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 281090003959 CAAX protease self-immunity; Region: Abi; pfam02517 281090003960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281090003961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090003962 short chain dehydrogenase; Provisional; Region: PRK06523 281090003963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090003964 NAD(P) binding site [chemical binding]; other site 281090003965 active site 281090003966 quinolinate synthetase; Provisional; Region: PRK09375 281090003967 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 281090003968 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 281090003969 dimerization interface [polypeptide binding]; other site 281090003970 active site 281090003971 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 281090003972 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 281090003973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281090003974 catalytic residue [active] 281090003975 NYN domain; Region: NYN; pfam01936 281090003976 Uncharacterized conserved protein [Function unknown]; Region: COG1432 281090003977 putative metal binding site [ion binding]; other site 281090003978 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 281090003979 Homeodomain-like domain; Region: HTH_23; cl17451 281090003980 GTP-binding protein YchF; Reviewed; Region: PRK09601 281090003981 YchF GTPase; Region: YchF; cd01900 281090003982 G1 box; other site 281090003983 GTP/Mg2+ binding site [chemical binding]; other site 281090003984 Switch I region; other site 281090003985 G2 box; other site 281090003986 Switch II region; other site 281090003987 G3 box; other site 281090003988 G4 box; other site 281090003989 G5 box; other site 281090003990 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 281090003991 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 281090003992 active site 281090003993 catalytic site [active] 281090003994 substrate binding site [chemical binding]; other site 281090003995 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 281090003996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090003997 putative substrate translocation pore; other site 281090003998 RmuC family; Region: RmuC; pfam02646 281090003999 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 281090004000 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 281090004001 putative active site [active] 281090004002 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 281090004003 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 281090004004 active site 281090004005 intersubunit interface [polypeptide binding]; other site 281090004006 zinc binding site [ion binding]; other site 281090004007 Na+ binding site [ion binding]; other site 281090004008 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 281090004009 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 281090004010 NADP binding site [chemical binding]; other site 281090004011 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 281090004012 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 281090004013 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 281090004014 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 281090004015 generic binding surface II; other site 281090004016 generic binding surface I; other site 281090004017 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 281090004018 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 281090004019 active site clefts [active] 281090004020 zinc binding site [ion binding]; other site 281090004021 dimer interface [polypeptide binding]; other site 281090004022 fumarate hydratase; Reviewed; Region: fumC; PRK00485 281090004023 Class II fumarases; Region: Fumarase_classII; cd01362 281090004024 active site 281090004025 tetramer interface [polypeptide binding]; other site 281090004026 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 281090004027 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 281090004028 putative active site [active] 281090004029 PhoH-like protein; Region: PhoH; pfam02562 281090004030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 281090004031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281090004032 catalytic residue [active] 281090004033 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 281090004034 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 281090004035 catalytic residue [active] 281090004036 putative FPP diphosphate binding site; other site 281090004037 putative FPP binding hydrophobic cleft; other site 281090004038 dimer interface [polypeptide binding]; other site 281090004039 putative IPP diphosphate binding site; other site 281090004040 Haemolysin-III related; Region: HlyIII; pfam03006 281090004041 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 281090004042 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 281090004043 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 281090004044 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 281090004045 threonine dehydratase; Provisional; Region: PRK08198 281090004046 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 281090004047 tetramer interface [polypeptide binding]; other site 281090004048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090004049 catalytic residue [active] 281090004050 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 281090004051 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 281090004052 Domain of unknown function DUF20; Region: UPF0118; pfam01594 281090004053 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 281090004054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 281090004055 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 281090004056 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 281090004057 hypothetical protein; Provisional; Region: PRK04233 281090004058 SEC-C motif; Region: SEC-C; pfam02810 281090004059 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 281090004060 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 281090004061 substrate binding site [chemical binding]; other site 281090004062 dimer interface [polypeptide binding]; other site 281090004063 ATP binding site [chemical binding]; other site 281090004064 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 281090004065 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 281090004066 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 281090004067 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090004068 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 281090004069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 281090004070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090004071 ABC-ATPase subunit interface; other site 281090004072 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281090004073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281090004074 DNA binding site [nucleotide binding] 281090004075 domain linker motif; other site 281090004076 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 281090004077 ligand binding site [chemical binding]; other site 281090004078 dimerization interface [polypeptide binding]; other site 281090004079 Uncharacterized conserved protein [Function unknown]; Region: COG1739 281090004080 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 281090004081 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 281090004082 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 281090004083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281090004084 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 281090004085 active site 281090004086 catalytic residues [active] 281090004087 Protein of unknown function (DUF501); Region: DUF501; pfam04417 281090004088 Septum formation initiator; Region: DivIC; pfam04977 281090004089 enolase; Provisional; Region: eno; PRK00077 281090004090 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 281090004091 dimer interface [polypeptide binding]; other site 281090004092 metal binding site [ion binding]; metal-binding site 281090004093 substrate binding pocket [chemical binding]; other site 281090004094 HTH-like domain; Region: HTH_21; pfam13276 281090004095 Integrase core domain; Region: rve; pfam00665 281090004096 histidyl-tRNA synthetase; Region: hisS; TIGR00442 281090004097 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 281090004098 dimer interface [polypeptide binding]; other site 281090004099 motif 1; other site 281090004100 active site 281090004101 motif 2; other site 281090004102 motif 3; other site 281090004103 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 281090004104 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 281090004105 Walker A/P-loop; other site 281090004106 ATP binding site [chemical binding]; other site 281090004107 Q-loop/lid; other site 281090004108 ABC transporter signature motif; other site 281090004109 Walker B; other site 281090004110 D-loop; other site 281090004111 H-loop/switch region; other site 281090004112 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 281090004113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281090004114 putative PBP binding regions; other site 281090004115 FecCD transport family; Region: FecCD; pfam01032 281090004116 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 281090004117 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 281090004118 siderophore binding site; other site 281090004119 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 281090004120 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 281090004121 homodimer interface [polypeptide binding]; other site 281090004122 metal binding site [ion binding]; metal-binding site 281090004123 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 281090004124 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 281090004125 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 281090004126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090004127 ATP binding site [chemical binding]; other site 281090004128 putative Mg++ binding site [ion binding]; other site 281090004129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090004130 nucleotide binding region [chemical binding]; other site 281090004131 ATP-binding site [chemical binding]; other site 281090004132 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 281090004133 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 281090004134 putative active site [active] 281090004135 catalytic residue [active] 281090004136 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 281090004137 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 281090004138 5S rRNA interface [nucleotide binding]; other site 281090004139 CTC domain interface [polypeptide binding]; other site 281090004140 L16 interface [polypeptide binding]; other site 281090004141 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 281090004142 metal binding site [ion binding]; metal-binding site 281090004143 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 281090004144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281090004145 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281090004146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281090004147 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 281090004148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281090004149 ligand binding site [chemical binding]; other site 281090004150 dimerization interface [polypeptide binding]; other site 281090004151 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 281090004152 glucuronate isomerase; Reviewed; Region: PRK02925 281090004153 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 281090004154 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 281090004155 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 281090004156 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281090004157 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090004158 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 281090004159 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 281090004160 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 281090004161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090004162 active site 281090004163 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 281090004164 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 281090004165 Substrate binding site; other site 281090004166 Mg++ binding site; other site 281090004167 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 281090004168 active site 281090004169 substrate binding site [chemical binding]; other site 281090004170 CoA binding site [chemical binding]; other site 281090004171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281090004172 MarR family; Region: MarR_2; cl17246 281090004173 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 281090004174 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 281090004175 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 281090004176 putative ADP-binding pocket [chemical binding]; other site 281090004177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 281090004178 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 281090004179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090004180 Walker A/P-loop; other site 281090004181 ATP binding site [chemical binding]; other site 281090004182 Q-loop/lid; other site 281090004183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281090004184 ABC transporter; Region: ABC_tran_2; pfam12848 281090004185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 281090004186 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 281090004187 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 281090004188 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 281090004189 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 281090004190 active site 281090004191 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 281090004192 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 281090004193 active site 281090004194 HIGH motif; other site 281090004195 KMSKS motif; other site 281090004196 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 281090004197 tRNA binding surface [nucleotide binding]; other site 281090004198 anticodon binding site; other site 281090004199 Predicted methyltransferases [General function prediction only]; Region: COG0313 281090004200 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 281090004201 putative SAM binding site [chemical binding]; other site 281090004202 putative homodimer interface [polypeptide binding]; other site 281090004203 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 281090004204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090004205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 281090004206 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 281090004207 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 281090004208 putative active site [active] 281090004209 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 281090004210 catalytic residues [active] 281090004211 dimer interface [polypeptide binding]; other site 281090004212 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 281090004213 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 281090004214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090004215 catalytic residue [active] 281090004216 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 281090004217 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 281090004218 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 281090004219 dimer interface [polypeptide binding]; other site 281090004220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090004221 catalytic residue [active] 281090004222 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 281090004223 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 281090004224 dimer interface [polypeptide binding]; other site 281090004225 putative radical transfer pathway; other site 281090004226 diiron center [ion binding]; other site 281090004227 tyrosyl radical; other site 281090004228 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 281090004229 ATP cone domain; Region: ATP-cone; pfam03477 281090004230 Class I ribonucleotide reductase; Region: RNR_I; cd01679 281090004231 active site 281090004232 dimer interface [polypeptide binding]; other site 281090004233 catalytic residues [active] 281090004234 effector binding site; other site 281090004235 R2 peptide binding site; other site 281090004236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090004237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281090004238 putative substrate translocation pore; other site 281090004239 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 281090004240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 281090004241 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 281090004242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 281090004243 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 281090004244 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 281090004245 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 281090004246 active site 281090004247 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 281090004248 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 281090004249 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 281090004250 active site 281090004251 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 281090004252 NlpC/P60 family; Region: NLPC_P60; pfam00877 281090004253 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 281090004254 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 281090004255 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 281090004256 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 281090004257 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 281090004258 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281090004259 catalytic residue [active] 281090004260 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 281090004261 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281090004262 DNA-binding site [nucleotide binding]; DNA binding site 281090004263 RNA-binding motif; other site 281090004264 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 281090004265 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 281090004266 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 281090004267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090004268 ATP binding site [chemical binding]; other site 281090004269 putative Mg++ binding site [ion binding]; other site 281090004270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090004271 nucleotide binding region [chemical binding]; other site 281090004272 ATP-binding site [chemical binding]; other site 281090004273 hypothetical protein; Provisional; Region: PRK14059 281090004274 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 281090004275 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 281090004276 dihydropteroate synthase; Region: DHPS; TIGR01496 281090004277 substrate binding pocket [chemical binding]; other site 281090004278 dimer interface [polypeptide binding]; other site 281090004279 inhibitor binding site; inhibition site 281090004280 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090004281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090004282 active site 281090004283 phosphorylation site [posttranslational modification] 281090004284 intermolecular recognition site; other site 281090004285 dimerization interface [polypeptide binding]; other site 281090004286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090004287 DNA binding site [nucleotide binding] 281090004288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090004289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 281090004290 dimerization interface [polypeptide binding]; other site 281090004291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090004292 dimer interface [polypeptide binding]; other site 281090004293 phosphorylation site [posttranslational modification] 281090004294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090004295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090004296 ATP binding site [chemical binding]; other site 281090004297 Mg2+ binding site [ion binding]; other site 281090004298 G-X-G motif; other site 281090004299 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 281090004300 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 281090004301 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 281090004302 ring oligomerisation interface [polypeptide binding]; other site 281090004303 ATP/Mg binding site [chemical binding]; other site 281090004304 stacking interactions; other site 281090004305 hinge regions; other site 281090004306 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281090004307 DNA-binding site [nucleotide binding]; DNA binding site 281090004308 RNA-binding motif; other site 281090004309 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 281090004310 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 281090004311 methionine sulfoxide reductase B; Provisional; Region: PRK00222 281090004312 SelR domain; Region: SelR; pfam01641 281090004313 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 281090004314 putative FMN binding site [chemical binding]; other site 281090004315 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 281090004316 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 281090004317 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281090004318 Catalytic site [active] 281090004319 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 281090004320 FAD binding pocket [chemical binding]; other site 281090004321 FAD binding motif [chemical binding]; other site 281090004322 phosphate binding motif [ion binding]; other site 281090004323 NAD binding pocket [chemical binding]; other site 281090004324 YCII-related domain; Region: YCII; cl00999 281090004325 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 281090004326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 281090004327 active site 281090004328 dimerization interface [polypeptide binding]; other site 281090004329 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 281090004330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090004331 ATP binding site [chemical binding]; other site 281090004332 Mg2+ binding site [ion binding]; other site 281090004333 G-X-G motif; other site 281090004334 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 281090004335 Citrate transporter; Region: CitMHS; pfam03600 281090004336 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 281090004337 Thioredoxin; Region: Thioredoxin_4; cl17273 281090004338 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 281090004339 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 281090004340 Walker A/P-loop; other site 281090004341 ATP binding site [chemical binding]; other site 281090004342 Q-loop/lid; other site 281090004343 ABC transporter signature motif; other site 281090004344 Walker B; other site 281090004345 D-loop; other site 281090004346 H-loop/switch region; other site 281090004347 TOBE domain; Region: TOBE_2; pfam08402 281090004348 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 281090004349 Domain of unknown function (DUF336); Region: DUF336; pfam03928 281090004350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281090004351 Histidine kinase; Region: HisKA_3; pfam07730 281090004352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090004353 ATP binding site [chemical binding]; other site 281090004354 Mg2+ binding site [ion binding]; other site 281090004355 G-X-G motif; other site 281090004356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090004357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090004358 active site 281090004359 phosphorylation site [posttranslational modification] 281090004360 intermolecular recognition site; other site 281090004361 dimerization interface [polypeptide binding]; other site 281090004362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090004363 DNA binding residues [nucleotide binding] 281090004364 dimerization interface [polypeptide binding]; other site 281090004365 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 281090004366 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 281090004367 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 281090004368 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 281090004369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 281090004370 active site 281090004371 HIGH motif; other site 281090004372 nucleotide binding site [chemical binding]; other site 281090004373 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 281090004374 KMSKS motif; other site 281090004375 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 281090004376 tRNA binding surface [nucleotide binding]; other site 281090004377 anticodon binding site; other site 281090004378 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 281090004379 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 281090004380 substrate binding site; other site 281090004381 dimer interface; other site 281090004382 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 281090004383 homotrimer interaction site [polypeptide binding]; other site 281090004384 zinc binding site [ion binding]; other site 281090004385 CDP-binding sites; other site 281090004386 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 281090004387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090004388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090004389 active site 281090004390 phosphorylation site [posttranslational modification] 281090004391 intermolecular recognition site; other site 281090004392 dimerization interface [polypeptide binding]; other site 281090004393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090004394 DNA binding site [nucleotide binding] 281090004395 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 281090004396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090004397 dimer interface [polypeptide binding]; other site 281090004398 phosphorylation site [posttranslational modification] 281090004399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090004400 ATP binding site [chemical binding]; other site 281090004401 Mg2+ binding site [ion binding]; other site 281090004402 G-X-G motif; other site 281090004403 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 281090004404 PhoU domain; Region: PhoU; pfam01895 281090004405 PhoU domain; Region: PhoU; pfam01895 281090004406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281090004407 catalytic core [active] 281090004408 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 281090004409 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 281090004410 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 281090004411 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 281090004412 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 281090004413 heme-binding site [chemical binding]; other site 281090004414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090004415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090004416 DNA binding site [nucleotide binding] 281090004417 PBP superfamily domain; Region: PBP_like_2; cl17296 281090004418 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 281090004419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090004420 dimer interface [polypeptide binding]; other site 281090004421 conserved gate region; other site 281090004422 putative PBP binding loops; other site 281090004423 ABC-ATPase subunit interface; other site 281090004424 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 281090004425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090004426 dimer interface [polypeptide binding]; other site 281090004427 conserved gate region; other site 281090004428 putative PBP binding loops; other site 281090004429 ABC-ATPase subunit interface; other site 281090004430 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 281090004431 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 281090004432 Walker A/P-loop; other site 281090004433 ATP binding site [chemical binding]; other site 281090004434 Q-loop/lid; other site 281090004435 ABC transporter signature motif; other site 281090004436 Walker B; other site 281090004437 D-loop; other site 281090004438 H-loop/switch region; other site 281090004439 Anti-sigma-K factor rskA; Region: RskA; pfam10099 281090004440 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 281090004441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090004442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281090004443 DNA binding residues [nucleotide binding] 281090004444 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 281090004445 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 281090004446 putative ion selectivity filter; other site 281090004447 putative pore gating glutamate residue; other site 281090004448 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 281090004449 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 281090004450 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 281090004451 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 281090004452 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 281090004453 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 281090004454 Ankyrin repeat; Region: Ank; pfam00023 281090004455 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 281090004456 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 281090004457 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 281090004458 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 281090004459 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 281090004460 trimer interface [polypeptide binding]; other site 281090004461 putative metal binding site [ion binding]; other site 281090004462 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 281090004463 putative dimer interface [polypeptide binding]; other site 281090004464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 281090004465 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 281090004466 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 281090004467 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 281090004468 homodimer interface [polypeptide binding]; other site 281090004469 NADP binding site [chemical binding]; other site 281090004470 substrate binding site [chemical binding]; other site 281090004471 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 281090004472 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 281090004473 dimer interface [polypeptide binding]; other site 281090004474 active site 281090004475 glycine-pyridoxal phosphate binding site [chemical binding]; other site 281090004476 folate binding site [chemical binding]; other site 281090004477 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 281090004478 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 281090004479 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 281090004480 active site 281090004481 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 281090004482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090004483 Walker A/P-loop; other site 281090004484 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090004485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090004486 DNA binding residues [nucleotide binding] 281090004487 dimerization interface [polypeptide binding]; other site 281090004488 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 281090004489 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 281090004490 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 281090004491 RHS Repeat; Region: RHS_repeat; cl11982 281090004492 RHS Repeat; Region: RHS_repeat; cl11982 281090004493 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090004494 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090004495 Integrase core domain; Region: rve; pfam00665 281090004496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090004497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090004498 dimer interface [polypeptide binding]; other site 281090004499 phosphorylation site [posttranslational modification] 281090004500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090004501 ATP binding site [chemical binding]; other site 281090004502 Mg2+ binding site [ion binding]; other site 281090004503 G-X-G motif; other site 281090004504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090004505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090004506 active site 281090004507 phosphorylation site [posttranslational modification] 281090004508 intermolecular recognition site; other site 281090004509 dimerization interface [polypeptide binding]; other site 281090004510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090004511 DNA binding site [nucleotide binding] 281090004512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090004513 ABC transporter signature motif; other site 281090004514 Walker B; other site 281090004515 D-loop; other site 281090004516 H-loop/switch region; other site 281090004517 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 281090004518 23S rRNA binding site [nucleotide binding]; other site 281090004519 L21 binding site [polypeptide binding]; other site 281090004520 L13 binding site [polypeptide binding]; other site 281090004521 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 281090004522 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 281090004523 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 281090004524 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 281090004525 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 281090004526 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281090004527 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 281090004528 ligand binding site [chemical binding]; other site 281090004529 active site 281090004530 UGI interface [polypeptide binding]; other site 281090004531 catalytic site [active] 281090004532 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 281090004533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090004534 active site 281090004535 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 281090004536 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 281090004537 homodimer interface [polypeptide binding]; other site 281090004538 substrate-cofactor binding pocket; other site 281090004539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090004540 catalytic residue [active] 281090004541 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 281090004542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090004543 NAD(P) binding site [chemical binding]; other site 281090004544 active site 281090004545 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 281090004546 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 281090004547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 281090004548 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 281090004549 ATP binding site [chemical binding]; other site 281090004550 Mg2+ binding site [ion binding]; other site 281090004551 G-X-G motif; other site 281090004552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090004553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 281090004554 active site 281090004555 dimerization interface [polypeptide binding]; other site 281090004556 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 281090004557 DNA binding residues [nucleotide binding] 281090004558 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 281090004559 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 281090004560 active site 281090004561 ATP binding site [chemical binding]; other site 281090004562 substrate binding site [chemical binding]; other site 281090004563 activation loop (A-loop); other site 281090004564 Domain of unknown function DUF77; Region: DUF77; pfam01910 281090004565 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 281090004566 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 281090004567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090004568 motif II; other site 281090004569 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 281090004570 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 281090004571 active site 281090004572 FMN binding site [chemical binding]; other site 281090004573 substrate binding site [chemical binding]; other site 281090004574 homotetramer interface [polypeptide binding]; other site 281090004575 catalytic residue [active] 281090004576 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281090004577 Domain of unknown function DUF21; Region: DUF21; pfam01595 281090004578 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281090004579 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 281090004580 Domain of unknown function DUF21; Region: DUF21; pfam01595 281090004581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 281090004582 Transporter associated domain; Region: CorC_HlyC; smart01091 281090004583 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 281090004584 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 281090004585 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 281090004586 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 281090004587 active site 281090004588 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 281090004589 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281090004590 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 281090004591 TPP-binding site [chemical binding]; other site 281090004592 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 281090004593 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 281090004594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090004595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 281090004596 DNA binding residues [nucleotide binding] 281090004597 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 281090004598 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 281090004599 hinge; other site 281090004600 active site 281090004601 Predicted GTPases [General function prediction only]; Region: COG1162 281090004602 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 281090004603 GTPase/Zn-binding domain interface [polypeptide binding]; other site 281090004604 GTP/Mg2+ binding site [chemical binding]; other site 281090004605 G4 box; other site 281090004606 G5 box; other site 281090004607 G1 box; other site 281090004608 Switch I region; other site 281090004609 G2 box; other site 281090004610 G3 box; other site 281090004611 Switch II region; other site 281090004612 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 281090004613 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 281090004614 catalytic triad [active] 281090004615 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 281090004616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090004617 Walker A/P-loop; other site 281090004618 ATP binding site [chemical binding]; other site 281090004619 Q-loop/lid; other site 281090004620 ABC transporter signature motif; other site 281090004621 Walker B; other site 281090004622 D-loop; other site 281090004623 H-loop/switch region; other site 281090004624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281090004625 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 281090004626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 281090004627 Walker A/P-loop; other site 281090004628 ATP binding site [chemical binding]; other site 281090004629 Q-loop/lid; other site 281090004630 ABC transporter signature motif; other site 281090004631 Walker B; other site 281090004632 D-loop; other site 281090004633 H-loop/switch region; other site 281090004634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 281090004635 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 281090004636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090004637 dimer interface [polypeptide binding]; other site 281090004638 conserved gate region; other site 281090004639 putative PBP binding loops; other site 281090004640 ABC-ATPase subunit interface; other site 281090004641 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 281090004642 Transcription factor WhiB; Region: Whib; pfam02467 281090004643 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 281090004644 PAS fold; Region: PAS_4; pfam08448 281090004645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 281090004646 Histidine kinase; Region: HisKA_2; pfam07568 281090004647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090004648 ATP binding site [chemical binding]; other site 281090004649 Mg2+ binding site [ion binding]; other site 281090004650 G-X-G motif; other site 281090004651 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 281090004652 dimer interface [polypeptide binding]; other site 281090004653 active site 281090004654 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 281090004655 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281090004656 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 281090004657 putative substrate binding site [chemical binding]; other site 281090004658 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 281090004659 intersubunit interface [polypeptide binding]; other site 281090004660 active site 281090004661 zinc binding site [ion binding]; other site 281090004662 Na+ binding site [ion binding]; other site 281090004663 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 281090004664 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 281090004665 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 281090004666 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 281090004667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 281090004668 active site 281090004669 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 281090004670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090004671 Putative zinc-finger; Region: zf-HC2; pfam13490 281090004672 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 281090004673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090004674 putative substrate translocation pore; other site 281090004675 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 281090004676 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 281090004677 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 281090004678 putative active site [active] 281090004679 putative substrate binding site [chemical binding]; other site 281090004680 putative cosubstrate binding site; other site 281090004681 catalytic site [active] 281090004682 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 281090004683 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 281090004684 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 281090004685 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 281090004686 nucleophilic elbow; other site 281090004687 catalytic triad; other site 281090004688 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 281090004689 active site 281090004690 trimer interface [polypeptide binding]; other site 281090004691 allosteric site; other site 281090004692 active site lid [active] 281090004693 hexamer (dimer of trimers) interface [polypeptide binding]; other site 281090004694 isocitrate dehydrogenase; Validated; Region: PRK08299 281090004695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 281090004696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281090004697 Coenzyme A binding pocket [chemical binding]; other site 281090004698 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 281090004699 DNA binding site [nucleotide binding] 281090004700 active site 281090004701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090004702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090004703 active site 281090004704 phosphorylation site [posttranslational modification] 281090004705 intermolecular recognition site; other site 281090004706 dimerization interface [polypeptide binding]; other site 281090004707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090004708 DNA binding residues [nucleotide binding] 281090004709 dimerization interface [polypeptide binding]; other site 281090004710 DoxX-like family; Region: DoxX_2; pfam13564 281090004711 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 281090004712 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 281090004713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 281090004714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 281090004715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090004716 Walker A/P-loop; other site 281090004717 ATP binding site [chemical binding]; other site 281090004718 Q-loop/lid; other site 281090004719 ABC transporter signature motif; other site 281090004720 Walker B; other site 281090004721 D-loop; other site 281090004722 H-loop/switch region; other site 281090004723 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 281090004724 Amidinotransferase; Region: Amidinotransf; cl12043 281090004725 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 281090004726 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 281090004727 purine monophosphate binding site [chemical binding]; other site 281090004728 dimer interface [polypeptide binding]; other site 281090004729 putative catalytic residues [active] 281090004730 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 281090004731 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 281090004732 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 281090004733 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 281090004734 active site 281090004735 substrate binding site [chemical binding]; other site 281090004736 cosubstrate binding site; other site 281090004737 catalytic site [active] 281090004738 Uncharacterized conserved protein [Function unknown]; Region: COG2966 281090004739 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 281090004740 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 281090004741 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 281090004742 CoA binding domain; Region: CoA_binding; smart00881 281090004743 CoA-ligase; Region: Ligase_CoA; pfam00549 281090004744 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 281090004745 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 281090004746 CoA-ligase; Region: Ligase_CoA; pfam00549 281090004747 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 281090004748 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 281090004749 Part of AAA domain; Region: AAA_19; pfam13245 281090004750 Family description; Region: UvrD_C_2; pfam13538 281090004751 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 281090004752 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 281090004753 active site 281090004754 catalytic site [active] 281090004755 Bax inhibitor 1 like; Region: BaxI_1; cl17691 281090004756 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 281090004757 GMP synthase; Reviewed; Region: guaA; PRK00074 281090004758 AMP/PPi binding site [chemical binding]; other site 281090004759 candidate oxyanion hole; other site 281090004760 catalytic triad [active] 281090004761 potential glutamine specificity residues [chemical binding]; other site 281090004762 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 281090004763 ATP Binding subdomain [chemical binding]; other site 281090004764 Ligand Binding sites [chemical binding]; other site 281090004765 Dimerization subdomain; other site 281090004766 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 281090004767 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 281090004768 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 281090004769 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 281090004770 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 281090004771 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 281090004772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 281090004773 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 281090004774 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 281090004775 phosphate binding site [ion binding]; other site 281090004776 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 281090004777 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 281090004778 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 281090004779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 281090004780 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 281090004781 active site 281090004782 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 281090004783 oligomerisation interface [polypeptide binding]; other site 281090004784 mobile loop; other site 281090004785 roof hairpin; other site 281090004786 UGMP family protein; Validated; Region: PRK09604 281090004787 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 281090004788 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 281090004789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 281090004790 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 281090004791 Glycoprotease family; Region: Peptidase_M22; pfam00814 281090004792 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 281090004793 alanine racemase; Reviewed; Region: alr; PRK00053 281090004794 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 281090004795 active site 281090004796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 281090004797 dimer interface [polypeptide binding]; other site 281090004798 substrate binding site [chemical binding]; other site 281090004799 catalytic residues [active] 281090004800 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 281090004801 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 281090004802 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 281090004803 glutaminase active site [active] 281090004804 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 281090004805 dimer interface [polypeptide binding]; other site 281090004806 active site 281090004807 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 281090004808 dimer interface [polypeptide binding]; other site 281090004809 active site 281090004810 pantothenate kinase; Provisional; Region: PRK05439 281090004811 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 281090004812 ATP-binding site [chemical binding]; other site 281090004813 CoA-binding site [chemical binding]; other site 281090004814 Mg2+-binding site [ion binding]; other site 281090004815 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 281090004816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090004817 non-specific DNA binding site [nucleotide binding]; other site 281090004818 salt bridge; other site 281090004819 sequence-specific DNA binding site [nucleotide binding]; other site 281090004820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090004821 non-specific DNA binding site [nucleotide binding]; other site 281090004822 salt bridge; other site 281090004823 sequence-specific DNA binding site [nucleotide binding]; other site 281090004824 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 281090004825 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 281090004826 active site 281090004827 substrate binding site [chemical binding]; other site 281090004828 metal binding site [ion binding]; metal-binding site 281090004829 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 281090004830 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 281090004831 23S rRNA interface [nucleotide binding]; other site 281090004832 L3 interface [polypeptide binding]; other site 281090004833 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 281090004834 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 281090004835 dimerization interface 3.5A [polypeptide binding]; other site 281090004836 active site 281090004837 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 281090004838 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 281090004839 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 281090004840 catalytic triad [active] 281090004841 catalytic triad [active] 281090004842 oxyanion hole [active] 281090004843 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 281090004844 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 281090004845 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 281090004846 alphaNTD homodimer interface [polypeptide binding]; other site 281090004847 alphaNTD - beta interaction site [polypeptide binding]; other site 281090004848 alphaNTD - beta' interaction site [polypeptide binding]; other site 281090004849 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 281090004850 30S ribosomal protein S11; Validated; Region: PRK05309 281090004851 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 281090004852 30S ribosomal protein S13; Region: bact_S13; TIGR03631 281090004853 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 281090004854 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 281090004855 rRNA binding site [nucleotide binding]; other site 281090004856 predicted 30S ribosome binding site; other site 281090004857 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 281090004858 active site 281090004859 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 281090004860 adenylate kinase; Reviewed; Region: adk; PRK00279 281090004861 AMP-binding site [chemical binding]; other site 281090004862 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 281090004863 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 281090004864 SecY translocase; Region: SecY; pfam00344 281090004865 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 281090004866 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 281090004867 23S rRNA binding site [nucleotide binding]; other site 281090004868 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 281090004869 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 281090004870 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 281090004871 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 281090004872 5S rRNA interface [nucleotide binding]; other site 281090004873 L27 interface [polypeptide binding]; other site 281090004874 23S rRNA interface [nucleotide binding]; other site 281090004875 L5 interface [polypeptide binding]; other site 281090004876 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 281090004877 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 281090004878 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 281090004879 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 281090004880 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 281090004881 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 281090004882 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 281090004883 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 281090004884 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 281090004885 RNA binding site [nucleotide binding]; other site 281090004886 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 281090004887 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 281090004888 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 281090004889 23S rRNA interface [nucleotide binding]; other site 281090004890 putative translocon interaction site; other site 281090004891 signal recognition particle (SRP54) interaction site; other site 281090004892 L23 interface [polypeptide binding]; other site 281090004893 trigger factor interaction site; other site 281090004894 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 281090004895 23S rRNA interface [nucleotide binding]; other site 281090004896 5S rRNA interface [nucleotide binding]; other site 281090004897 putative antibiotic binding site [chemical binding]; other site 281090004898 L25 interface [polypeptide binding]; other site 281090004899 L27 interface [polypeptide binding]; other site 281090004900 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 281090004901 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 281090004902 G-X-X-G motif; other site 281090004903 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 281090004904 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 281090004905 protein-rRNA interface [nucleotide binding]; other site 281090004906 putative translocon binding site; other site 281090004907 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 281090004908 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 281090004909 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 281090004910 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 281090004911 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 281090004912 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 281090004913 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 281090004914 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 281090004915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 281090004916 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 281090004917 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 281090004918 active site 281090004919 elongation factor Tu; Reviewed; Region: PRK00049 281090004920 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 281090004921 G1 box; other site 281090004922 GEF interaction site [polypeptide binding]; other site 281090004923 GTP/Mg2+ binding site [chemical binding]; other site 281090004924 Switch I region; other site 281090004925 G2 box; other site 281090004926 G3 box; other site 281090004927 Switch II region; other site 281090004928 G4 box; other site 281090004929 G5 box; other site 281090004930 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 281090004931 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 281090004932 Antibiotic Binding Site [chemical binding]; other site 281090004933 elongation factor G; Reviewed; Region: PRK00007 281090004934 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 281090004935 G1 box; other site 281090004936 putative GEF interaction site [polypeptide binding]; other site 281090004937 GTP/Mg2+ binding site [chemical binding]; other site 281090004938 Switch I region; other site 281090004939 G2 box; other site 281090004940 G3 box; other site 281090004941 Switch II region; other site 281090004942 G4 box; other site 281090004943 G5 box; other site 281090004944 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 281090004945 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 281090004946 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 281090004947 30S ribosomal protein S7; Validated; Region: PRK05302 281090004948 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 281090004949 S17 interaction site [polypeptide binding]; other site 281090004950 S8 interaction site; other site 281090004951 16S rRNA interaction site [nucleotide binding]; other site 281090004952 streptomycin interaction site [chemical binding]; other site 281090004953 23S rRNA interaction site [nucleotide binding]; other site 281090004954 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 281090004955 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 281090004956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 281090004957 ABC-ATPase subunit interface; other site 281090004958 dimer interface [polypeptide binding]; other site 281090004959 putative PBP binding regions; other site 281090004960 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 281090004961 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 281090004962 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 281090004963 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 281090004964 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 281090004965 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 281090004966 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 281090004967 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090004968 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090004969 Integrase core domain; Region: rve; pfam00665 281090004970 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 281090004971 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 281090004972 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 281090004973 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 281090004974 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 281090004975 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 281090004976 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 281090004977 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 281090004978 G-loop; other site 281090004979 DNA binding site [nucleotide binding] 281090004980 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 281090004981 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 281090004982 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 281090004983 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 281090004984 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 281090004985 RPB10 interaction site [polypeptide binding]; other site 281090004986 RPB1 interaction site [polypeptide binding]; other site 281090004987 RPB11 interaction site [polypeptide binding]; other site 281090004988 RPB3 interaction site [polypeptide binding]; other site 281090004989 RPB12 interaction site [polypeptide binding]; other site 281090004990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090004991 S-adenosylmethionine binding site [chemical binding]; other site 281090004992 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 281090004993 CGNR zinc finger; Region: zf-CGNR; pfam11706 281090004994 SprT-like family; Region: SprT-like; pfam10263 281090004995 SprT homologues; Region: SprT; cl01182 281090004996 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 281090004997 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 281090004998 Part of AAA domain; Region: AAA_19; pfam13245 281090004999 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 281090005000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 281090005001 ATP binding site [chemical binding]; other site 281090005002 putative Mg++ binding site [ion binding]; other site 281090005003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090005004 nucleotide binding region [chemical binding]; other site 281090005005 ATP-binding site [chemical binding]; other site 281090005006 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 281090005007 nudix motif; other site 281090005008 Predicted esterase [General function prediction only]; Region: COG0400 281090005009 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 281090005010 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 281090005011 putative DNA binding site [nucleotide binding]; other site 281090005012 catalytic residue [active] 281090005013 putative H2TH interface [polypeptide binding]; other site 281090005014 putative catalytic residues [active] 281090005015 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 281090005016 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 281090005017 Transcriptional regulator [Transcription]; Region: LytR; COG1316 281090005018 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 281090005019 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 281090005020 tetracycline repressor protein TetR; Provisional; Region: PRK13756 281090005021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090005022 BioY family; Region: BioY; pfam02632 281090005023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 281090005024 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 281090005025 active site 281090005026 AMP binding site [chemical binding]; other site 281090005027 acyl-activating enzyme (AAE) consensus motif; other site 281090005028 CoA binding site [chemical binding]; other site 281090005029 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 281090005030 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 281090005031 dimer interface [polypeptide binding]; other site 281090005032 active site 281090005033 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281090005034 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281090005035 Walker A/P-loop; other site 281090005036 ATP binding site [chemical binding]; other site 281090005037 Q-loop/lid; other site 281090005038 ABC transporter signature motif; other site 281090005039 Walker B; other site 281090005040 D-loop; other site 281090005041 H-loop/switch region; other site 281090005042 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 281090005043 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 281090005044 CHY zinc finger; Region: zf-CHY; pfam05495 281090005045 Protein of unknown function (DUF805); Region: DUF805; pfam05656 281090005046 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 281090005047 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 281090005048 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 281090005049 FeoA domain; Region: FeoA; pfam04023 281090005050 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 281090005051 ferrous iron transporter FeoB; Region: feoB; TIGR00437 281090005052 G1 box; other site 281090005053 GTP/Mg2+ binding site [chemical binding]; other site 281090005054 Switch I region; other site 281090005055 G2 box; other site 281090005056 G3 box; other site 281090005057 Switch II region; other site 281090005058 G4 box; other site 281090005059 G5 box; other site 281090005060 Nucleoside recognition; Region: Gate; pfam07670 281090005061 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 281090005062 Nucleoside recognition; Region: Gate; pfam07670 281090005063 NifU-like domain; Region: NifU; cl00484 281090005064 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 281090005065 Protein of unknown function (DUF461); Region: DUF461; pfam04314 281090005066 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 281090005067 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 281090005068 catalytic residues [active] 281090005069 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 281090005070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005071 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090005072 DNA binding residues [nucleotide binding] 281090005073 dimerization interface [polypeptide binding]; other site 281090005074 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 281090005075 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 281090005076 DXD motif; other site 281090005077 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 281090005078 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 281090005079 active site 281090005080 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 281090005081 homodimer interface [polypeptide binding]; other site 281090005082 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281090005083 Catalytic site [active] 281090005084 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090005086 DNA binding residues [nucleotide binding] 281090005087 dimerization interface [polypeptide binding]; other site 281090005088 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090005089 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090005090 Integrase core domain; Region: rve; pfam00665 281090005091 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 281090005092 MgtC family; Region: MgtC; pfam02308 281090005093 magnesium-transporting ATPase; Provisional; Region: PRK15122 281090005094 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 281090005095 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 281090005096 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 281090005097 Soluble P-type ATPase [General function prediction only]; Region: COG4087 281090005098 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 281090005099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005100 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090005101 DNA binding residues [nucleotide binding] 281090005102 dimerization interface [polypeptide binding]; other site 281090005103 Thioredoxin; Region: Thioredoxin_4; cl17273 281090005104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090005106 DNA binding residues [nucleotide binding] 281090005107 dimerization interface [polypeptide binding]; other site 281090005108 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 281090005109 active site 281090005110 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 281090005111 Catalytic site [active] 281090005112 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 281090005113 active site 281090005114 oxyanion hole [active] 281090005115 catalytic triad [active] 281090005116 DNA repair protein RadA; Provisional; Region: PRK11823 281090005117 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 281090005118 Walker A motif; other site 281090005119 ATP binding site [chemical binding]; other site 281090005120 Walker B motif; other site 281090005121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281090005122 Coenzyme A binding pocket [chemical binding]; other site 281090005123 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 281090005124 Clp amino terminal domain; Region: Clp_N; pfam02861 281090005125 Clp amino terminal domain; Region: Clp_N; pfam02861 281090005126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090005127 Walker A motif; other site 281090005128 ATP binding site [chemical binding]; other site 281090005129 Walker B motif; other site 281090005130 arginine finger; other site 281090005131 UvrB/uvrC motif; Region: UVR; pfam02151 281090005132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090005133 Walker A motif; other site 281090005134 ATP binding site [chemical binding]; other site 281090005135 Walker B motif; other site 281090005136 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 281090005137 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 281090005138 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 281090005139 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 281090005140 putative active site [active] 281090005141 catalytic site [active] 281090005142 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 281090005143 putative active site [active] 281090005144 catalytic site [active] 281090005145 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 281090005146 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 281090005147 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 281090005148 dimer interface [polypeptide binding]; other site 281090005149 putative anticodon binding site; other site 281090005150 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 281090005151 motif 1; other site 281090005152 dimer interface [polypeptide binding]; other site 281090005153 active site 281090005154 motif 2; other site 281090005155 motif 3; other site 281090005156 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 281090005157 pantoate--beta-alanine ligase; Region: panC; TIGR00018 281090005158 active site 281090005159 nucleotide binding site [chemical binding]; other site 281090005160 HIGH motif; other site 281090005161 KMSKS motif; other site 281090005162 Rossmann-like domain; Region: Rossmann-like; pfam10727 281090005163 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 281090005164 Predicted membrane protein [Function unknown]; Region: COG3428 281090005165 Bacterial PH domain; Region: DUF304; pfam03703 281090005166 Bacterial PH domain; Region: DUF304; cl01348 281090005167 Bacterial PH domain; Region: DUF304; pfam03703 281090005168 Bacterial PH domain; Region: DUF304; cl01348 281090005169 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 281090005170 catalytic center binding site [active] 281090005171 ATP binding site [chemical binding]; other site 281090005172 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 281090005173 homooctamer interface [polypeptide binding]; other site 281090005174 active site 281090005175 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 281090005176 dihydropteroate synthase; Region: DHPS; TIGR01496 281090005177 substrate binding pocket [chemical binding]; other site 281090005178 dimer interface [polypeptide binding]; other site 281090005179 inhibitor binding site; inhibition site 281090005180 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 281090005181 GTP cyclohydrolase I; Provisional; Region: PLN03044 281090005182 active site 281090005183 FtsH Extracellular; Region: FtsH_ext; pfam06480 281090005184 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 281090005185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090005186 Walker A motif; other site 281090005187 ATP binding site [chemical binding]; other site 281090005188 Walker B motif; other site 281090005189 arginine finger; other site 281090005190 Peptidase family M41; Region: Peptidase_M41; pfam01434 281090005191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090005192 active site 281090005193 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 281090005194 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 281090005195 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 281090005196 dimer interface [polypeptide binding]; other site 281090005197 substrate binding site [chemical binding]; other site 281090005198 metal binding sites [ion binding]; metal-binding site 281090005199 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 281090005200 NlpC/P60 family; Region: NLPC_P60; pfam00877 281090005201 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 281090005202 Peptidase family M23; Region: Peptidase_M23; pfam01551 281090005203 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281090005204 active site 281090005205 catalytic residues [active] 281090005206 DNA binding site [nucleotide binding] 281090005207 Int/Topo IB signature motif; other site 281090005208 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 281090005209 DNA binding site [nucleotide binding] 281090005210 active site 281090005211 Int/Topo IB signature motif; other site 281090005212 catalytic residues [active] 281090005213 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 281090005214 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 281090005215 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 281090005216 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005217 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005218 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005219 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005220 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005221 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005222 Immunoglobulin domain; Region: Ig; cl11960 281090005223 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281090005224 Catalytic site [active] 281090005225 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 281090005226 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 281090005227 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 281090005228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 281090005229 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 281090005230 DNA binding residues [nucleotide binding] 281090005231 Predicted ATPase [General function prediction only]; Region: COG3903 281090005232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005233 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 281090005234 DNA binding residues [nucleotide binding] 281090005235 dimerization interface [polypeptide binding]; other site 281090005236 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 281090005237 active site 281090005238 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 281090005239 dimer interface [polypeptide binding]; other site 281090005240 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 281090005241 Ligand Binding Site [chemical binding]; other site 281090005242 Molecular Tunnel; other site 281090005243 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 281090005244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 281090005245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 281090005246 active site 281090005247 catalytic tetrad [active] 281090005248 Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808 281090005249 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 281090005250 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 281090005251 shikimate kinase; Provisional; Region: PRK13947 281090005252 AAA domain; Region: AAA_17; pfam13207 281090005253 acyl-coenzyme A oxidase; Region: PLN02636 281090005254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 281090005255 active site 281090005256 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 281090005257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 281090005258 ATP binding site [chemical binding]; other site 281090005259 putative Mg++ binding site [ion binding]; other site 281090005260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090005261 nucleotide binding region [chemical binding]; other site 281090005262 ATP-binding site [chemical binding]; other site 281090005263 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 281090005264 HRDC domain; Region: HRDC; pfam00570 281090005265 L-asparagine permease; Provisional; Region: PRK15049 281090005266 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 281090005267 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281090005268 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 281090005269 Walker A/P-loop; other site 281090005270 ATP binding site [chemical binding]; other site 281090005271 Q-loop/lid; other site 281090005272 ABC transporter signature motif; other site 281090005273 Walker B; other site 281090005274 D-loop; other site 281090005275 H-loop/switch region; other site 281090005276 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 281090005277 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 281090005278 Walker A/P-loop; other site 281090005279 ATP binding site [chemical binding]; other site 281090005280 Q-loop/lid; other site 281090005281 ABC transporter signature motif; other site 281090005282 Walker B; other site 281090005283 D-loop; other site 281090005284 H-loop/switch region; other site 281090005285 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 281090005286 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 281090005287 MarR family; Region: MarR; pfam01047 281090005288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090005290 DNA binding residues [nucleotide binding] 281090005291 dimerization interface [polypeptide binding]; other site 281090005292 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 281090005293 Catalytic site [active] 281090005294 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 281090005295 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 281090005296 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 281090005297 Amidase; Region: Amidase; cl11426 281090005298 argininosuccinate synthase; Validated; Region: PRK05370 281090005299 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 281090005300 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 281090005301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 281090005302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 281090005303 dimer interface [polypeptide binding]; other site 281090005304 phosphorylation site [posttranslational modification] 281090005305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 281090005306 ATP binding site [chemical binding]; other site 281090005307 Mg2+ binding site [ion binding]; other site 281090005308 G-X-G motif; other site 281090005309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 281090005310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090005311 active site 281090005312 phosphorylation site [posttranslational modification] 281090005313 intermolecular recognition site; other site 281090005314 dimerization interface [polypeptide binding]; other site 281090005315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 281090005316 DNA binding site [nucleotide binding] 281090005317 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281090005318 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281090005319 Walker A/P-loop; other site 281090005320 ATP binding site [chemical binding]; other site 281090005321 Q-loop/lid; other site 281090005322 ABC transporter signature motif; other site 281090005323 Walker B; other site 281090005324 D-loop; other site 281090005325 H-loop/switch region; other site 281090005326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 281090005327 FtsX-like permease family; Region: FtsX; pfam02687 281090005328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 281090005329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 281090005330 catalytic residue [active] 281090005331 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 281090005332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 281090005333 DEAD-like helicases superfamily; Region: DEXDc; smart00487 281090005334 ATP binding site [chemical binding]; other site 281090005335 putative Mg++ binding site [ion binding]; other site 281090005336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 281090005337 nucleotide binding region [chemical binding]; other site 281090005338 ATP-binding site [chemical binding]; other site 281090005339 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 281090005340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 281090005341 putative DNA binding site [nucleotide binding]; other site 281090005342 dimerization interface [polypeptide binding]; other site 281090005343 Transcriptional regulator [Transcription]; Region: IclR; COG1414 281090005344 putative Zn2+ binding site [ion binding]; other site 281090005345 Bacterial transcriptional regulator; Region: IclR; pfam01614 281090005346 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 281090005347 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 281090005348 active sites [active] 281090005349 tetramer interface [polypeptide binding]; other site 281090005350 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 281090005351 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 281090005352 putative ligand binding site [chemical binding]; other site 281090005353 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 281090005354 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 281090005355 Walker A/P-loop; other site 281090005356 ATP binding site [chemical binding]; other site 281090005357 Q-loop/lid; other site 281090005358 ABC transporter signature motif; other site 281090005359 Walker B; other site 281090005360 D-loop; other site 281090005361 H-loop/switch region; other site 281090005362 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 281090005363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 281090005364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 281090005365 TM-ABC transporter signature motif; other site 281090005366 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281090005367 Resolvase, N terminal domain; Region: Resolvase; smart00857 281090005368 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 281090005369 DNA-binding interface [nucleotide binding]; DNA binding site 281090005370 ribbon-helix-helix domain containing protein; Region: PHA00617 281090005371 Transposase, Mutator family; Region: Transposase_mut; pfam00872 281090005372 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 281090005373 Integrase core domain; Region: rve_3; cl15866 281090005374 Transposase; Region: DEDD_Tnp_IS110; pfam01548 281090005375 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 281090005376 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281090005377 DNA-binding site [nucleotide binding]; DNA binding site 281090005378 RNA-binding motif; other site 281090005379 Fatty acid desaturase; Region: FA_desaturase; pfam00487 281090005380 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 281090005381 putative di-iron ligands [ion binding]; other site 281090005382 Transposase, Mutator family; Region: Transposase_mut; pfam00872 281090005383 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 281090005384 active site 281090005385 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 281090005386 Winged helix-turn helix; Region: HTH_29; pfam13551 281090005387 Homeodomain-like domain; Region: HTH_32; pfam13565 281090005388 Integrase core domain; Region: rve; pfam00665 281090005389 Integrase core domain; Region: rve_3; pfam13683 281090005390 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 281090005391 EamA-like transporter family; Region: EamA; pfam00892 281090005392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 281090005393 Ligand Binding Site [chemical binding]; other site 281090005394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 281090005395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 281090005396 active site 281090005397 phosphorylation site [posttranslational modification] 281090005398 intermolecular recognition site; other site 281090005399 dimerization interface [polypeptide binding]; other site 281090005400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 281090005401 DNA binding residues [nucleotide binding] 281090005402 dimerization interface [polypeptide binding]; other site 281090005403 Helix-turn-helix domain; Region: HTH_38; pfam13936 281090005404 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 281090005405 Integrase core domain; Region: rve; pfam00665 281090005406 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 281090005407 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 281090005408 ligand binding site [chemical binding]; other site 281090005409 homodimer interface [polypeptide binding]; other site 281090005410 NAD(P) binding site [chemical binding]; other site 281090005411 trimer interface B [polypeptide binding]; other site 281090005412 trimer interface A [polypeptide binding]; other site 281090005413 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 281090005414 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 281090005415 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 281090005416 Transposase; Region: DEDD_Tnp_IS110; pfam01548 281090005417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 281090005418 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 281090005419 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 281090005420 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 281090005421 NAD(P) binding site [chemical binding]; other site 281090005422 catalytic residues [active] 281090005423 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 281090005424 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 281090005425 NAD binding site [chemical binding]; other site 281090005426 substrate binding site [chemical binding]; other site 281090005427 catalytic Zn binding site [ion binding]; other site 281090005428 tetramer interface [polypeptide binding]; other site 281090005429 structural Zn binding site [ion binding]; other site 281090005430 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 281090005431 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 281090005432 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281090005433 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281090005434 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 281090005435 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 281090005436 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 281090005437 CBD_II domain; Region: CBD_II; smart00637 281090005438 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 281090005439 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 281090005440 transposase; Provisional; Region: PRK06526 281090005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090005442 Walker A motif; other site 281090005443 ATP binding site [chemical binding]; other site 281090005444 Walker B motif; other site 281090005445 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 281090005446 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 281090005447 putative dimer interface [polypeptide binding]; other site 281090005448 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 281090005449 active site 281090005450 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090005451 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 281090005452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 281090005453 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 281090005454 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 281090005455 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 281090005456 dimerization interface [polypeptide binding]; other site 281090005457 putative ATP binding site [chemical binding]; other site 281090005458 amidophosphoribosyltransferase; Provisional; Region: PRK07847 281090005459 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 281090005460 active site 281090005461 tetramer interface [polypeptide binding]; other site 281090005462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090005463 active site 281090005464 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 281090005465 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 281090005466 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 281090005467 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 281090005468 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 281090005469 ATP binding site [chemical binding]; other site 281090005470 active site 281090005471 substrate binding site [chemical binding]; other site 281090005472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 281090005473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 281090005474 putative substrate translocation pore; other site 281090005475 Predicted transcriptional regulators [Transcription]; Region: COG1695 281090005476 Transcriptional regulator PadR-like family; Region: PadR; cl17335 281090005477 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281090005478 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 281090005479 catalytic residues [active] 281090005480 catalytic nucleophile [active] 281090005481 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 281090005482 Walker A motif; other site 281090005483 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 281090005484 Predicted transcriptional regulator [Transcription]; Region: COG2345 281090005485 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 281090005486 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 281090005487 NAD(P) binding site [chemical binding]; other site 281090005488 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 281090005489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090005490 motif II; other site 281090005491 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 281090005492 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 281090005493 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 281090005494 putative active site [active] 281090005495 catalytic triad [active] 281090005496 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 281090005497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281090005498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281090005499 DNA binding site [nucleotide binding] 281090005500 domain linker motif; other site 281090005501 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 281090005502 dimerization interface [polypeptide binding]; other site 281090005503 ligand binding site [chemical binding]; other site 281090005504 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 281090005505 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 281090005506 substrate binding site [chemical binding]; other site 281090005507 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 281090005508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090005509 dimer interface [polypeptide binding]; other site 281090005510 conserved gate region; other site 281090005511 putative PBP binding loops; other site 281090005512 ABC-ATPase subunit interface; other site 281090005513 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 281090005514 homotrimer interaction site [polypeptide binding]; other site 281090005515 putative active site [active] 281090005516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281090005517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090005518 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 281090005519 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 281090005520 dimerization interface [polypeptide binding]; other site 281090005521 ATP binding site [chemical binding]; other site 281090005522 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 281090005523 dimerization interface [polypeptide binding]; other site 281090005524 ATP binding site [chemical binding]; other site 281090005525 EamA-like transporter family; Region: EamA; pfam00892 281090005526 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 281090005527 Transglycosylase; Region: Transgly; pfam00912 281090005528 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 281090005529 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 281090005530 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 281090005531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 281090005532 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 281090005533 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 281090005534 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 281090005535 DXD motif; other site 281090005536 chorismate mutase; Provisional; Region: PRK09239 281090005537 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 281090005538 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 281090005539 Walker A/P-loop; other site 281090005540 ATP binding site [chemical binding]; other site 281090005541 Q-loop/lid; other site 281090005542 ABC transporter signature motif; other site 281090005543 Walker B; other site 281090005544 D-loop; other site 281090005545 H-loop/switch region; other site 281090005546 hypothetical protein; Provisional; Region: PRK01346 281090005547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 281090005548 Coenzyme A binding pocket [chemical binding]; other site 281090005549 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 281090005550 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 281090005551 GDP-binding site [chemical binding]; other site 281090005552 ACT binding site; other site 281090005553 IMP binding site; other site 281090005554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 281090005555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 281090005556 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 281090005557 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 281090005558 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 281090005559 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 281090005560 active site 281090005561 metal binding site [ion binding]; metal-binding site 281090005562 hexamer interface [polypeptide binding]; other site 281090005563 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 281090005564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090005565 UMP phosphatase; Provisional; Region: PRK10444 281090005566 active site 281090005567 motif I; other site 281090005568 motif II; other site 281090005569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 281090005570 Septum formation; Region: Septum_form; pfam13845 281090005571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 281090005572 active site 281090005573 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 281090005574 putative catalytic site [active] 281090005575 putative phosphate binding site [ion binding]; other site 281090005576 active site 281090005577 metal binding site A [ion binding]; metal-binding site 281090005578 DNA binding site [nucleotide binding] 281090005579 putative AP binding site [nucleotide binding]; other site 281090005580 putative metal binding site B [ion binding]; other site 281090005581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 281090005582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 281090005583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 281090005584 dimer interface [polypeptide binding]; other site 281090005585 putative PBP binding loops; other site 281090005586 ABC-ATPase subunit interface; other site 281090005587 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090005588 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 281090005589 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 281090005590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 281090005591 active site 281090005592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 281090005593 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 281090005594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 281090005595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 281090005596 DNA binding site [nucleotide binding] 281090005597 domain linker motif; other site 281090005598 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 281090005599 ligand binding site [chemical binding]; other site 281090005600 dimerization interface [polypeptide binding]; other site 281090005601 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 281090005602 dimer interface [polypeptide binding]; other site 281090005603 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 281090005604 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 281090005605 catalytic Zn binding site [ion binding]; other site 281090005606 NAD(P) binding site [chemical binding]; other site 281090005607 structural Zn binding site [ion binding]; other site 281090005608 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 281090005609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090005610 DNA-binding site [nucleotide binding]; DNA binding site 281090005611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090005612 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 281090005613 Walker A motif; other site 281090005614 ATP binding site [chemical binding]; other site 281090005615 Walker B motif; other site 281090005616 arginine finger; other site 281090005617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 281090005618 Walker A motif; other site 281090005619 ATP binding site [chemical binding]; other site 281090005620 Walker B motif; other site 281090005621 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 281090005622 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 281090005623 Spore germination protein; Region: Spore_permease; cl17796 281090005624 Copper resistance protein D; Region: CopD; pfam05425 281090005625 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 281090005626 CopC domain; Region: CopC; pfam04234 281090005627 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 281090005628 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 281090005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 281090005630 S-adenosylmethionine binding site [chemical binding]; other site 281090005631 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 281090005632 Catalytic site [active] 281090005633 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 281090005634 DNA binding residues [nucleotide binding] 281090005635 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 281090005636 putative dimer interface [polypeptide binding]; other site 281090005637 chaperone protein DnaJ; Provisional; Region: PRK14279 281090005638 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 281090005639 HSP70 interaction site [polypeptide binding]; other site 281090005640 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 281090005641 substrate binding site [polypeptide binding]; other site 281090005642 dimer interface [polypeptide binding]; other site 281090005643 GrpE; Region: GrpE; pfam01025 281090005644 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 281090005645 dimer interface [polypeptide binding]; other site 281090005646 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 281090005647 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 281090005648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 281090005649 nucleotide binding site [chemical binding]; other site 281090005650 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 281090005651 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 281090005652 synthetase active site [active] 281090005653 NTP binding site [chemical binding]; other site 281090005654 metal binding site [ion binding]; metal-binding site 281090005655 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 281090005656 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 281090005657 active site 281090005658 metal binding site [ion binding]; metal-binding site 281090005659 nudix motif; other site 281090005660 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 281090005661 trimer interface [polypeptide binding]; other site 281090005662 active site 281090005663 Domain of unknown function (DUF955); Region: DUF955; pfam06114 281090005664 BetR domain; Region: BetR; pfam08667 281090005665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 281090005666 non-specific DNA binding site [nucleotide binding]; other site 281090005667 salt bridge; other site 281090005668 sequence-specific DNA binding site [nucleotide binding]; other site 281090005669 Prophage antirepressor [Transcription]; Region: COG3617 281090005670 BRO family, N-terminal domain; Region: Bro-N; smart01040 281090005671 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 281090005672 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 281090005673 RecT family; Region: RecT; pfam03837 281090005674 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 281090005675 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 281090005676 Phage-related protein [Function unknown]; Region: COG4695; cl01923 281090005677 Phage portal protein; Region: Phage_portal; pfam04860 281090005678 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 281090005679 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 281090005680 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 281090005681 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 281090005682 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 281090005683 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 281090005684 Phage tail protein; Region: Sipho_tail; cl17486 281090005685 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 281090005686 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 281090005687 active site 281090005688 P63C domain; Region: P63C; pfam10546 281090005689 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 281090005690 metal binding triad [ion binding]; metal-binding site 281090005691 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 281090005692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090005693 DNA-binding site [nucleotide binding]; DNA binding site 281090005694 UTRA domain; Region: UTRA; pfam07702 281090005695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 281090005696 active site 281090005697 DNA binding site [nucleotide binding] 281090005698 Int/Topo IB signature motif; other site 281090005699 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 281090005700 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281090005701 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281090005702 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 281090005703 Class I aldolases; Region: Aldolase_Class_I; cl17187 281090005704 catalytic residue [active] 281090005705 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 281090005706 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 281090005707 DNA-binding site [nucleotide binding]; DNA binding site 281090005708 RNA-binding motif; other site 281090005709 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 281090005710 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 281090005711 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 281090005712 TrkA-C domain; Region: TrkA_C; pfam02080 281090005713 META domain; Region: META; pfam03724 281090005714 MMPL family; Region: MMPL; pfam03176 281090005715 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 281090005716 nudix motif; other site 281090005717 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 281090005718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 281090005719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 281090005720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 281090005721 dimerization interface [polypeptide binding]; other site 281090005722 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281090005723 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281090005724 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281090005725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 281090005726 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 281090005727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 281090005728 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 281090005729 Recombinase; Region: Recombinase; pfam07508 281090005730 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 281090005731 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 281090005732 catalytic residues [active] 281090005733 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 281090005734 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 281090005735 heme binding pocket [chemical binding]; other site 281090005736 heme ligand [chemical binding]; other site 281090005737 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 281090005738 phosphopeptide binding site; other site 281090005739 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 281090005740 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 281090005741 ATP binding site [chemical binding]; other site 281090005742 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 281090005743 Copper resistance protein D; Region: CopD; cl00563 281090005744 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 281090005745 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 281090005746 IHF dimer interface [polypeptide binding]; other site 281090005747 IHF - DNA interface [nucleotide binding]; other site 281090005748 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 281090005749 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 281090005750 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 281090005751 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 281090005752 metal binding site 2 [ion binding]; metal-binding site 281090005753 putative DNA binding helix; other site 281090005754 metal binding site 1 [ion binding]; metal-binding site 281090005755 dimer interface [polypeptide binding]; other site 281090005756 structural Zn2+ binding site [ion binding]; other site 281090005757 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 281090005758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 281090005759 putative PBP binding regions; other site 281090005760 ABC-ATPase subunit interface; other site 281090005761 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 281090005762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 281090005763 Walker A/P-loop; other site 281090005764 ATP binding site [chemical binding]; other site 281090005765 Q-loop/lid; other site 281090005766 ABC transporter signature motif; other site 281090005767 Walker B; other site 281090005768 D-loop; other site 281090005769 H-loop/switch region; other site 281090005770 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 281090005771 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 281090005772 intersubunit interface [polypeptide binding]; other site 281090005773 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 281090005774 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 281090005775 E3 interaction surface; other site 281090005776 lipoyl attachment site [posttranslational modification]; other site 281090005777 e3 binding domain; Region: E3_binding; pfam02817 281090005778 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 281090005779 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 281090005780 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 281090005781 alpha subunit interface [polypeptide binding]; other site 281090005782 TPP binding site [chemical binding]; other site 281090005783 heterodimer interface [polypeptide binding]; other site 281090005784 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 281090005785 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 281090005786 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 281090005787 TPP-binding site [chemical binding]; other site 281090005788 tetramer interface [polypeptide binding]; other site 281090005789 heterodimer interface [polypeptide binding]; other site 281090005790 phosphorylation loop region [posttranslational modification] 281090005791 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 281090005792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281090005793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090005794 homodimer interface [polypeptide binding]; other site 281090005795 catalytic residue [active] 281090005796 Membrane protein of unknown function; Region: DUF360; pfam04020 281090005797 adenylosuccinate lyase; Provisional; Region: PRK09285 281090005798 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 281090005799 tetramer interface [polypeptide binding]; other site 281090005800 active site 281090005801 Transcriptional regulators [Transcription]; Region: GntR; COG1802 281090005802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 281090005803 DNA-binding site [nucleotide binding]; DNA binding site 281090005804 replicative DNA helicase; Region: DnaB; TIGR00665 281090005805 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 281090005806 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 281090005807 Walker A motif; other site 281090005808 ATP binding site [chemical binding]; other site 281090005809 Walker B motif; other site 281090005810 DNA binding loops [nucleotide binding] 281090005811 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 281090005812 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 281090005813 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 281090005814 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 281090005815 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 281090005816 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 281090005817 dimer interface [polypeptide binding]; other site 281090005818 ssDNA binding site [nucleotide binding]; other site 281090005819 tetramer (dimer of dimers) interface [polypeptide binding]; other site 281090005820 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 281090005821 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 281090005822 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 281090005823 active site 281090005824 NTP binding site [chemical binding]; other site 281090005825 metal binding triad [ion binding]; metal-binding site 281090005826 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 281090005827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 281090005828 Zn2+ binding site [ion binding]; other site 281090005829 Mg2+ binding site [ion binding]; other site 281090005830 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 281090005831 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 281090005832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 281090005833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 281090005834 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 281090005835 catalytic residues [active] 281090005836 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 281090005837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 281090005838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 281090005839 homodimer interface [polypeptide binding]; other site 281090005840 catalytic residue [active] 281090005841 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 281090005842 ParB-like nuclease domain; Region: ParB; smart00470 281090005843 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 281090005844 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 281090005845 P-loop; other site 281090005846 Magnesium ion binding site [ion binding]; other site 281090005847 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 281090005848 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 281090005849 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 281090005850 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 281090005851 RxxxH motif; other site 281090005852 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 281090005853 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 281090005854 hypothetical protein; Provisional; Region: PRK14378 281090005855 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399