-- dump date 20140619_130741 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1389489000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1389489000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489000003 Walker A motif; other site 1389489000004 ATP binding site [chemical binding]; other site 1389489000005 Walker B motif; other site 1389489000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1389489000007 arginine finger; other site 1389489000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1389489000009 DnaA box-binding interface [nucleotide binding]; other site 1389489000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 1389489000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1389489000012 putative DNA binding surface [nucleotide binding]; other site 1389489000013 dimer interface [polypeptide binding]; other site 1389489000014 beta-clamp/clamp loader binding surface; other site 1389489000015 beta-clamp/translesion DNA polymerase binding surface; other site 1389489000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1389489000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1389489000018 recombination protein F; Reviewed; Region: recF; PRK00064 1389489000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489000020 Walker A/P-loop; other site 1389489000021 ATP binding site [chemical binding]; other site 1389489000022 Q-loop/lid; other site 1389489000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489000024 ABC transporter signature motif; other site 1389489000025 Walker B; other site 1389489000026 D-loop; other site 1389489000027 H-loop/switch region; other site 1389489000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 1389489000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1389489000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489000031 Mg2+ binding site [ion binding]; other site 1389489000032 G-X-G motif; other site 1389489000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1389489000034 anchoring element; other site 1389489000035 dimer interface [polypeptide binding]; other site 1389489000036 ATP binding site [chemical binding]; other site 1389489000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1389489000038 active site 1389489000039 putative metal-binding site [ion binding]; other site 1389489000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1389489000041 DNA gyrase subunit A; Validated; Region: PRK05560 1389489000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1389489000043 CAP-like domain; other site 1389489000044 active site 1389489000045 primary dimer interface [polypeptide binding]; other site 1389489000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1389489000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1389489000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1389489000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1389489000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1389489000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1389489000052 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1389489000053 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1389489000054 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1389489000055 Integrase core domain; Region: rve; pfam00665 1389489000056 Integrase core domain; Region: rve_3; pfam13683 1389489000057 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 1389489000058 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1389489000059 nudix motif; other site 1389489000060 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1389489000061 active site 1389489000062 Rhomboid family; Region: Rhomboid; cl11446 1389489000063 Rhomboid family; Region: Rhomboid; pfam01694 1389489000064 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489000065 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1389489000066 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1389489000067 active site 1389489000068 catalytic site [active] 1389489000069 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1389489000070 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1389489000071 glutamine binding [chemical binding]; other site 1389489000072 catalytic triad [active] 1389489000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1389489000074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1389489000075 active site 1389489000076 ATP binding site [chemical binding]; other site 1389489000077 substrate binding site [chemical binding]; other site 1389489000078 activation loop (A-loop); other site 1389489000079 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489000080 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489000081 PASTA domain; Region: PASTA; smart00740 1389489000082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1389489000083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1389489000084 active site 1389489000085 ATP binding site [chemical binding]; other site 1389489000086 substrate binding site [chemical binding]; other site 1389489000087 activation loop (A-loop); other site 1389489000088 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1389489000089 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1389489000090 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1389489000091 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1389489000092 active site 1389489000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1389489000094 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1389489000095 phosphopeptide binding site; other site 1389489000096 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1389489000097 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1389489000098 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1389489000099 phosphopeptide binding site; other site 1389489000100 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1389489000101 MarR family; Region: MarR; pfam01047 1389489000102 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1389489000103 NAD(P) binding site [chemical binding]; other site 1389489000104 shikimate binding site; other site 1389489000105 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1389489000106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1389489000107 dimerization interface [polypeptide binding]; other site 1389489000108 putative Zn2+ binding site [ion binding]; other site 1389489000109 putative DNA binding site [nucleotide binding]; other site 1389489000110 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489000111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1389489000112 nucleotide binding site [chemical binding]; other site 1389489000113 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1389489000114 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1389489000115 Walker A/P-loop; other site 1389489000116 ATP binding site [chemical binding]; other site 1389489000117 Q-loop/lid; other site 1389489000118 ABC transporter signature motif; other site 1389489000119 Walker B; other site 1389489000120 D-loop; other site 1389489000121 H-loop/switch region; other site 1389489000122 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1389489000123 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1389489000124 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1389489000125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1389489000126 TM-ABC transporter signature motif; other site 1389489000127 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1389489000128 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 1389489000129 putative ligand binding site [chemical binding]; other site 1389489000130 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1389489000131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489000132 DNA-binding site [nucleotide binding]; DNA binding site 1389489000133 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1389489000134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489000135 DNA-binding site [nucleotide binding]; DNA binding site 1389489000136 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1389489000137 CopC domain; Region: CopC; pfam04234 1389489000138 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1389489000139 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489000140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1389489000141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489000142 dimer interface [polypeptide binding]; other site 1389489000143 conserved gate region; other site 1389489000144 putative PBP binding loops; other site 1389489000145 ABC-ATPase subunit interface; other site 1389489000146 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1389489000147 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1389489000148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489000149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489000150 active site 1389489000151 phosphorylation site [posttranslational modification] 1389489000152 intermolecular recognition site; other site 1389489000153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489000154 DNA binding residues [nucleotide binding] 1389489000155 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1389489000156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1389489000157 Ligand Binding Site [chemical binding]; other site 1389489000158 CrcB-like protein; Region: CRCB; pfam02537 1389489000159 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1389489000160 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1389489000161 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1389489000162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1389489000163 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1389489000164 Integrase core domain; Region: rve; pfam00665 1389489000165 Integrase core domain; Region: rve_3; pfam13683 1389489000166 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1389489000167 homotrimer interaction site [polypeptide binding]; other site 1389489000168 putative active site [active] 1389489000169 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1389489000170 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1389489000171 Bacterial transcriptional regulator; Region: IclR; pfam01614 1389489000172 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1389489000173 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1389489000174 substrate binding site [chemical binding]; other site 1389489000175 ATP binding site [chemical binding]; other site 1389489000176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489000177 catalytic residue [active] 1389489000178 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489000179 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489000180 Class I aldolases; Region: Aldolase_Class_I; cl17187 1389489000181 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1389489000182 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1389489000183 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1389489000184 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1389489000185 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1389489000186 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1389489000187 active site 1389489000188 phosphorylation site [posttranslational modification] 1389489000189 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1389489000190 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1389489000191 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1389489000192 active site 1389489000193 P-loop; other site 1389489000194 phosphorylation site [posttranslational modification] 1389489000195 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1389489000196 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1389489000197 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1389489000198 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1389489000199 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1389489000200 dimerization domain swap beta strand [polypeptide binding]; other site 1389489000201 regulatory protein interface [polypeptide binding]; other site 1389489000202 active site 1389489000203 regulatory phosphorylation site [posttranslational modification]; other site 1389489000204 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1389489000205 active site 1389489000206 P-loop; other site 1389489000207 phosphorylation site [posttranslational modification] 1389489000208 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1389489000209 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1389489000210 Mga helix-turn-helix domain; Region: Mga; pfam05043 1389489000211 PRD domain; Region: PRD; pfam00874 1389489000212 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1389489000213 active site 1389489000214 P-loop; other site 1389489000215 phosphorylation site [posttranslational modification] 1389489000216 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1389489000217 active site 1389489000218 phosphorylation site [posttranslational modification] 1389489000219 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1389489000220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489000221 motif II; other site 1389489000222 hypothetical protein; Provisional; Region: PRK03298 1389489000223 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1389489000224 putative transporter; Provisional; Region: PRK12382 1389489000225 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1389489000226 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1389489000227 metal binding site [ion binding]; metal-binding site 1389489000228 putative dimer interface [polypeptide binding]; other site 1389489000229 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1389489000230 putative efflux protein, MATE family; Region: matE; TIGR00797 1389489000231 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1389489000232 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1389489000233 active site 1389489000234 Zn binding site [ion binding]; other site 1389489000235 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1389489000236 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1389489000237 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1389489000238 active site 1389489000239 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1389489000240 substrate binding site [chemical binding]; other site 1389489000241 catalytic residues [active] 1389489000242 dimer interface [polypeptide binding]; other site 1389489000243 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1389489000244 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489000245 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489000246 Integrase core domain; Region: rve; pfam00665 1389489000247 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1389489000248 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1389489000249 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1389489000250 motif 1; other site 1389489000251 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1389489000252 motif 1; other site 1389489000253 dimer interface [polypeptide binding]; other site 1389489000254 active site 1389489000255 motif 2; other site 1389489000256 motif 3; other site 1389489000257 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1389489000258 anticodon binding site; other site 1389489000259 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1389489000260 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1389489000261 NAD(P) binding pocket [chemical binding]; other site 1389489000262 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1389489000263 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1389489000264 substrate binding site [chemical binding]; other site 1389489000265 active site 1389489000266 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 1389489000267 ferrochelatase; Reviewed; Region: hemH; PRK00035 1389489000268 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1389489000269 C-terminal domain interface [polypeptide binding]; other site 1389489000270 active site 1389489000271 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1389489000272 active site 1389489000273 N-terminal domain interface [polypeptide binding]; other site 1389489000274 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1389489000275 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1389489000276 domain interfaces; other site 1389489000277 active site 1389489000278 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1389489000279 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1389489000280 active site 1389489000281 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1389489000282 dimer interface [polypeptide binding]; other site 1389489000283 active site 1389489000284 Schiff base residues; other site 1389489000285 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1389489000286 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1389489000287 inhibitor-cofactor binding pocket; inhibition site 1389489000288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489000289 catalytic residue [active] 1389489000290 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1389489000291 S-layer homology domain; Region: SLH; pfam00395 1389489000292 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1389489000293 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1389489000294 active site 1389489000295 tetramer interface [polypeptide binding]; other site 1389489000296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489000297 active site 1389489000298 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1389489000299 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1389489000300 dimerization interface [polypeptide binding]; other site 1389489000301 putative ATP binding site [chemical binding]; other site 1389489000302 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1389489000303 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1389489000304 Predicted transcriptional regulators [Transcription]; Region: COG1695 1389489000305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1389489000306 putative DNA binding site [nucleotide binding]; other site 1389489000307 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1389489000308 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1389489000309 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1389489000310 DNA binding residues [nucleotide binding] 1389489000311 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1389489000312 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1389489000313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489000314 DNA-binding site [nucleotide binding]; DNA binding site 1389489000315 FCD domain; Region: FCD; pfam07729 1389489000316 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1389489000317 Protein export membrane protein; Region: SecD_SecF; cl14618 1389489000318 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1389489000319 active site 1389489000320 metal binding site [ion binding]; metal-binding site 1389489000321 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1389489000322 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1389489000323 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1389489000324 calcium mediated ligand binding site; other site 1389489000325 intermolecular salt bridges; other site 1389489000326 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1389489000327 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1389489000328 Transglycosylase; Region: Transgly; pfam00912 1389489000329 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1389489000330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1389489000331 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1389489000332 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1389489000333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1389489000334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1389489000335 active site 1389489000336 catalytic tetrad [active] 1389489000337 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1389489000338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1389489000339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1389489000340 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1389489000341 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1389489000342 Walker A/P-loop; other site 1389489000343 ATP binding site [chemical binding]; other site 1389489000344 Q-loop/lid; other site 1389489000345 ABC transporter signature motif; other site 1389489000346 Walker B; other site 1389489000347 D-loop; other site 1389489000348 H-loop/switch region; other site 1389489000349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1389489000350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1389489000351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489000352 Walker A/P-loop; other site 1389489000353 ATP binding site [chemical binding]; other site 1389489000354 Q-loop/lid; other site 1389489000355 ABC transporter signature motif; other site 1389489000356 Walker B; other site 1389489000357 D-loop; other site 1389489000358 H-loop/switch region; other site 1389489000359 RibD C-terminal domain; Region: RibD_C; cl17279 1389489000360 transposase/IS protein; Provisional; Region: PRK09183 1389489000361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489000362 Walker A motif; other site 1389489000363 ATP binding site [chemical binding]; other site 1389489000364 Walker B motif; other site 1389489000365 IPT/TIG domain; Region: TIG; pfam01833 1389489000366 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1389489000367 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1389489000368 Amidase; Region: Amidase; cl11426 1389489000369 argininosuccinate synthase; Validated; Region: PRK05370 1389489000370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1389489000371 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1389489000372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1389489000373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1389489000374 Walker A/P-loop; other site 1389489000375 ATP binding site [chemical binding]; other site 1389489000376 Q-loop/lid; other site 1389489000377 ABC transporter signature motif; other site 1389489000378 Walker B; other site 1389489000379 D-loop; other site 1389489000380 H-loop/switch region; other site 1389489000381 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1389489000382 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1389489000383 FtsX-like permease family; Region: FtsX; pfam02687 1389489000384 tyrosine decarboxylase; Region: PLN02880 1389489000385 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1389489000386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489000387 catalytic residue [active] 1389489000388 Integrase core domain; Region: rve; pfam00665 1389489000389 Integrase core domain; Region: rve_3; pfam13683 1389489000390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1389489000391 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1389489000392 ATP binding site [chemical binding]; other site 1389489000393 putative Mg++ binding site [ion binding]; other site 1389489000394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489000395 nucleotide binding region [chemical binding]; other site 1389489000396 ATP-binding site [chemical binding]; other site 1389489000397 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1389489000398 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1389489000399 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1389489000400 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1389489000401 Bacterial transcriptional regulator; Region: IclR; pfam01614 1389489000402 urocanate hydratase; Provisional; Region: PRK05414 1389489000403 urocanate hydratase; Provisional; Region: PRK05414 1389489000404 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1389489000405 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1389489000406 Walker A/P-loop; other site 1389489000407 ATP binding site [chemical binding]; other site 1389489000408 Q-loop/lid; other site 1389489000409 ABC transporter signature motif; other site 1389489000410 Walker B; other site 1389489000411 D-loop; other site 1389489000412 H-loop/switch region; other site 1389489000413 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1389489000414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489000415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489000416 DNA binding site [nucleotide binding] 1389489000417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489000418 active site 1389489000419 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1389489000420 nucleoside/Zn binding site; other site 1389489000421 dimer interface [polypeptide binding]; other site 1389489000422 catalytic motif [active] 1389489000423 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1389489000424 Cation efflux family; Region: Cation_efflux; pfam01545 1389489000425 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1389489000426 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1389489000427 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1389489000428 TrkA-N domain; Region: TrkA_N; pfam02254 1389489000429 TrkA-C domain; Region: TrkA_C; pfam02080 1389489000430 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1389489000431 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1389489000432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1389489000433 dimerization interface [polypeptide binding]; other site 1389489000434 putative DNA binding site [nucleotide binding]; other site 1389489000435 putative Zn2+ binding site [ion binding]; other site 1389489000436 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489000437 DNA binding domain, excisionase family; Region: excise; TIGR01764 1389489000438 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1389489000439 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1389489000440 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1389489000441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489000442 DNA-binding site [nucleotide binding]; DNA binding site 1389489000443 FCD domain; Region: FCD; pfam07729 1389489000444 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1389489000445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489000446 DNA-binding site [nucleotide binding]; DNA binding site 1389489000447 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1389489000448 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1389489000449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489000450 S-adenosylmethionine binding site [chemical binding]; other site 1389489000451 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1389489000452 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1389489000453 substrate binding pocket [chemical binding]; other site 1389489000454 chain length determination region; other site 1389489000455 substrate-Mg2+ binding site; other site 1389489000456 catalytic residues [active] 1389489000457 aspartate-rich region 1; other site 1389489000458 active site lid residues [active] 1389489000459 aspartate-rich region 2; other site 1389489000460 ferredoxin-NADP+ reductase; Region: PLN02852 1389489000461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1389489000462 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1389489000463 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1389489000464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1389489000465 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489000466 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1389489000467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1389489000468 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1389489000469 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1389489000470 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1389489000471 active site 1389489000472 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1389489000473 Peptidase family M23; Region: Peptidase_M23; pfam01551 1389489000474 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1389489000475 active site 1389489000476 catalytic site [active] 1389489000477 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489000478 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1389489000479 Integrase core domain; Region: rve; pfam00665 1389489000480 Integrase core domain; Region: rve_3; pfam13683 1389489000481 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1389489000482 succinic semialdehyde dehydrogenase; Region: PLN02278 1389489000483 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1389489000484 tetramerization interface [polypeptide binding]; other site 1389489000485 NAD(P) binding site [chemical binding]; other site 1389489000486 catalytic residues [active] 1389489000487 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1389489000488 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1389489000489 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1389489000490 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1389489000491 tetramer interface [polypeptide binding]; other site 1389489000492 heme binding pocket [chemical binding]; other site 1389489000493 NADPH binding site [chemical binding]; other site 1389489000494 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1389489000495 metal binding site 2 [ion binding]; metal-binding site 1389489000496 putative DNA binding helix; other site 1389489000497 metal binding site 1 [ion binding]; metal-binding site 1389489000498 dimer interface [polypeptide binding]; other site 1389489000499 structural Zn2+ binding site [ion binding]; other site 1389489000500 Short C-terminal domain; Region: SHOCT; pfam09851 1389489000501 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1389489000502 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1389489000503 active site 1389489000504 catalytic site [active] 1389489000505 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1389489000506 active site 1389489000507 catalytic site [active] 1389489000508 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1389489000509 FAD binding domain; Region: FAD_binding_4; pfam01565 1389489000510 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1389489000511 Integrase core domain; Region: rve; pfam00665 1389489000512 Integrase core domain; Region: rve_3; pfam13683 1389489000513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489000514 sequence-specific DNA binding site [nucleotide binding]; other site 1389489000515 salt bridge; other site 1389489000516 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1389489000517 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1389489000518 mRNA/rRNA interface [nucleotide binding]; other site 1389489000519 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1389489000520 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1389489000521 23S rRNA interface [nucleotide binding]; other site 1389489000522 L7/L12 interface [polypeptide binding]; other site 1389489000523 putative thiostrepton binding site; other site 1389489000524 L25 interface [polypeptide binding]; other site 1389489000525 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1389489000526 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1389489000527 putative homodimer interface [polypeptide binding]; other site 1389489000528 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1389489000529 heterodimer interface [polypeptide binding]; other site 1389489000530 homodimer interface [polypeptide binding]; other site 1389489000531 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1389489000532 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1389489000533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489000534 ATP binding site [chemical binding]; other site 1389489000535 putative Mg++ binding site [ion binding]; other site 1389489000536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489000537 nucleotide binding region [chemical binding]; other site 1389489000538 ATP-binding site [chemical binding]; other site 1389489000539 Integrase core domain; Region: rve; pfam00665 1389489000540 Integrase core domain; Region: rve_3; pfam13683 1389489000541 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1389489000542 Catalytic site [active] 1389489000543 AAA domain; Region: AAA_22; pfam13401 1389489000544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489000545 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489000546 DNA binding residues [nucleotide binding] 1389489000547 dimerization interface [polypeptide binding]; other site 1389489000548 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1389489000549 N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; Region: GlcNAc-1-P_transferase; cd06436 1389489000550 DXD motif; other site 1389489000551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489000552 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1389489000553 active site 1389489000554 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1389489000555 homodimer interface [polypeptide binding]; other site 1389489000556 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1389489000557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489000558 DNA-binding site [nucleotide binding]; DNA binding site 1389489000559 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1389489000560 active site 1389489000561 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489000562 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489000563 Integrase core domain; Region: rve; pfam00665 1389489000564 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1389489000565 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1389489000566 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1389489000567 Catalytic site [active] 1389489000568 AAA ATPase domain; Region: AAA_16; pfam13191 1389489000569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489000570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489000571 DNA binding residues [nucleotide binding] 1389489000572 dimerization interface [polypeptide binding]; other site 1389489000573 Putative Ig domain; Region: He_PIG; pfam05345 1389489000574 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1389489000575 MgtC family; Region: MgtC; pfam02308 1389489000576 magnesium-transporting ATPase; Provisional; Region: PRK15122 1389489000577 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1389489000578 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1389489000579 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1389489000580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1389489000581 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1389489000582 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489000583 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1389489000584 DNA binding residues [nucleotide binding] 1389489000585 dimerization interface [polypeptide binding]; other site 1389489000586 Thioredoxin; Region: Thioredoxin_4; cl17273 1389489000587 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1389489000588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489000589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489000590 DNA binding residues [nucleotide binding] 1389489000591 dimerization interface [polypeptide binding]; other site 1389489000592 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1389489000593 active site 1389489000594 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1389489000595 Catalytic site [active] 1389489000596 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1389489000597 active site 1389489000598 catalytic triad [active] 1389489000599 oxyanion hole [active] 1389489000600 DNA repair protein RadA; Provisional; Region: PRK11823 1389489000601 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1389489000602 Walker A motif; other site 1389489000603 ATP binding site [chemical binding]; other site 1389489000604 Walker B motif; other site 1389489000605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1389489000606 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1389489000607 Clp amino terminal domain; Region: Clp_N; pfam02861 1389489000608 Clp amino terminal domain; Region: Clp_N; pfam02861 1389489000609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489000610 Walker A motif; other site 1389489000611 ATP binding site [chemical binding]; other site 1389489000612 Walker B motif; other site 1389489000613 arginine finger; other site 1389489000614 UvrB/uvrC motif; Region: UVR; pfam02151 1389489000615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489000616 Walker A motif; other site 1389489000617 ATP binding site [chemical binding]; other site 1389489000618 Walker B motif; other site 1389489000619 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1389489000620 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1389489000621 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1389489000622 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1389489000623 putative active site [active] 1389489000624 catalytic site [active] 1389489000625 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1389489000626 putative active site [active] 1389489000627 catalytic site [active] 1389489000628 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1389489000629 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1389489000630 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1389489000631 dimer interface [polypeptide binding]; other site 1389489000632 putative anticodon binding site; other site 1389489000633 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1389489000634 motif 1; other site 1389489000635 dimer interface [polypeptide binding]; other site 1389489000636 active site 1389489000637 motif 2; other site 1389489000638 motif 3; other site 1389489000639 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 1389489000640 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1389489000641 active site 1389489000642 nucleotide binding site [chemical binding]; other site 1389489000643 HIGH motif; other site 1389489000644 KMSKS motif; other site 1389489000645 Rossmann-like domain; Region: Rossmann-like; pfam10727 1389489000646 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1389489000647 Predicted membrane protein [Function unknown]; Region: COG3428 1389489000648 Bacterial PH domain; Region: DUF304; pfam03703 1389489000649 Bacterial PH domain; Region: DUF304; pfam03703 1389489000650 Bacterial PH domain; Region: DUF304; pfam03703 1389489000651 Bacterial PH domain; Region: DUF304; cl01348 1389489000652 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1389489000653 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1389489000654 catalytic center binding site [active] 1389489000655 ATP binding site [chemical binding]; other site 1389489000656 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1389489000657 homooctamer interface [polypeptide binding]; other site 1389489000658 active site 1389489000659 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1389489000660 dihydropteroate synthase; Region: DHPS; TIGR01496 1389489000661 substrate binding pocket [chemical binding]; other site 1389489000662 dimer interface [polypeptide binding]; other site 1389489000663 inhibitor binding site; inhibition site 1389489000664 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1389489000665 active site 1389489000666 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1389489000667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489000668 Walker A motif; other site 1389489000669 ATP binding site [chemical binding]; other site 1389489000670 Walker B motif; other site 1389489000671 arginine finger; other site 1389489000672 Peptidase family M41; Region: Peptidase_M41; pfam01434 1389489000673 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489000674 active site 1389489000675 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1389489000676 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1389489000677 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1389489000678 dimer interface [polypeptide binding]; other site 1389489000679 substrate binding site [chemical binding]; other site 1389489000680 metal binding sites [ion binding]; metal-binding site 1389489000681 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1389489000682 NlpC/P60 family; Region: NLPC_P60; pfam00877 1389489000683 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1389489000684 Peptidase family M23; Region: Peptidase_M23; pfam01551 1389489000685 Integrase core domain; Region: rve; pfam00665 1389489000686 Integrase core domain; Region: rve_3; pfam13683 1389489000687 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1389489000688 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1389489000689 catalytic residues [active] 1389489000690 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1389489000691 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1389489000692 NifU-like domain; Region: NifU; cl00484 1389489000693 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1389489000694 ferrous iron transporter FeoB; Region: feoB; TIGR00437 1389489000695 G1 box; other site 1389489000696 GTP/Mg2+ binding site [chemical binding]; other site 1389489000697 Switch I region; other site 1389489000698 G2 box; other site 1389489000699 G3 box; other site 1389489000700 Switch II region; other site 1389489000701 G4 box; other site 1389489000702 G5 box; other site 1389489000703 Nucleoside recognition; Region: Gate; pfam07670 1389489000704 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1389489000705 FeoA domain; Region: FeoA; pfam04023 1389489000706 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1389489000707 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1389489000708 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1389489000709 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1389489000710 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1389489000711 CHY zinc finger; Region: zf-CHY; pfam05495 1389489000712 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1389489000713 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1389489000714 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1389489000715 Walker A/P-loop; other site 1389489000716 ATP binding site [chemical binding]; other site 1389489000717 Q-loop/lid; other site 1389489000718 ABC transporter signature motif; other site 1389489000719 Walker B; other site 1389489000720 D-loop; other site 1389489000721 H-loop/switch region; other site 1389489000722 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1389489000723 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1389489000724 active site 1389489000725 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1389489000726 active site 1389489000727 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1389489000728 AMP binding site [chemical binding]; other site 1389489000729 active site 1389489000730 acyl-activating enzyme (AAE) consensus motif; other site 1389489000731 CoA binding site [chemical binding]; other site 1389489000732 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1389489000733 BioY family; Region: BioY; pfam02632 1389489000734 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1389489000735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489000736 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1389489000737 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1389489000738 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1389489000739 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1389489000740 putative DNA binding site [nucleotide binding]; other site 1389489000741 catalytic residue [active] 1389489000742 putative H2TH interface [polypeptide binding]; other site 1389489000743 putative catalytic residues [active] 1389489000744 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1389489000745 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1389489000746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489000747 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1389489000748 ATP binding site [chemical binding]; other site 1389489000749 putative Mg++ binding site [ion binding]; other site 1389489000750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489000751 nucleotide binding region [chemical binding]; other site 1389489000752 ATP-binding site [chemical binding]; other site 1389489000753 DEAD/H associated; Region: DEAD_assoc; pfam08494 1389489000754 Predicted esterase [General function prediction only]; Region: COG0400 1389489000755 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1389489000756 nudix motif; other site 1389489000757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1389489000758 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1389489000759 ATP binding site [chemical binding]; other site 1389489000760 putative Mg++ binding site [ion binding]; other site 1389489000761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489000762 nucleotide binding region [chemical binding]; other site 1389489000763 ATP-binding site [chemical binding]; other site 1389489000764 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 1389489000765 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1389489000766 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1389489000767 SprT-like family; Region: SprT-like; pfam10263 1389489000768 SprT homologues; Region: SprT; cl01182 1389489000769 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1389489000770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1389489000771 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1389489000772 CGNR zinc finger; Region: zf-CGNR; pfam11706 1389489000773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1389489000774 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1389489000775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1389489000776 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1389489000777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1389489000778 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1389489000779 RPB10 interaction site [polypeptide binding]; other site 1389489000780 RPB1 interaction site [polypeptide binding]; other site 1389489000781 RPB11 interaction site [polypeptide binding]; other site 1389489000782 RPB3 interaction site [polypeptide binding]; other site 1389489000783 RPB12 interaction site [polypeptide binding]; other site 1389489000784 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1389489000785 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1389489000786 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1389489000787 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1389489000788 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1389489000789 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1389489000790 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1389489000791 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1389489000792 G-loop; other site 1389489000793 DNA binding site [nucleotide binding] 1389489000794 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1389489000795 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1389489000796 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1389489000797 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1389489000798 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 1389489000799 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1389489000800 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1389489000801 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1389489000802 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1389489000803 ABC-ATPase subunit interface; other site 1389489000804 dimer interface [polypeptide binding]; other site 1389489000805 putative PBP binding regions; other site 1389489000806 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1389489000807 S17 interaction site [polypeptide binding]; other site 1389489000808 16S rRNA interaction site [nucleotide binding]; other site 1389489000809 streptomycin interaction site [chemical binding]; other site 1389489000810 23S rRNA interaction site [nucleotide binding]; other site 1389489000811 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1389489000812 30S ribosomal protein S7; Validated; Region: PRK05302 1389489000813 elongation factor G; Reviewed; Region: PRK00007 1389489000814 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1389489000815 G1 box; other site 1389489000816 putative GEF interaction site [polypeptide binding]; other site 1389489000817 GTP/Mg2+ binding site [chemical binding]; other site 1389489000818 Switch I region; other site 1389489000819 G2 box; other site 1389489000820 G3 box; other site 1389489000821 Switch II region; other site 1389489000822 G4 box; other site 1389489000823 G5 box; other site 1389489000824 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1389489000825 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1389489000826 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1389489000827 elongation factor Tu; Reviewed; Region: PRK00049 1389489000828 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1389489000829 G1 box; other site 1389489000830 GEF interaction site [polypeptide binding]; other site 1389489000831 GTP/Mg2+ binding site [chemical binding]; other site 1389489000832 Switch I region; other site 1389489000833 G2 box; other site 1389489000834 G3 box; other site 1389489000835 Switch II region; other site 1389489000836 G4 box; other site 1389489000837 G5 box; other site 1389489000838 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1389489000839 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1389489000840 Antibiotic Binding Site [chemical binding]; other site 1389489000841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1389489000842 active site 1389489000843 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1389489000844 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1389489000845 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489000846 active site 1389489000847 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489000848 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489000849 Integrase core domain; Region: rve; pfam00665 1389489000850 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1389489000851 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1389489000852 MMPL family; Region: MMPL; pfam03176 1389489000853 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1389489000854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1389489000855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489000856 non-specific DNA binding site [nucleotide binding]; other site 1389489000857 salt bridge; other site 1389489000858 sequence-specific DNA binding site [nucleotide binding]; other site 1389489000859 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1389489000860 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1389489000861 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1389489000862 active site 1389489000863 substrate-binding site [chemical binding]; other site 1389489000864 metal-binding site [ion binding] 1389489000865 GTP binding site [chemical binding]; other site 1389489000866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1389489000867 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1389489000868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489000869 Walker A/P-loop; other site 1389489000870 ATP binding site [chemical binding]; other site 1389489000871 Q-loop/lid; other site 1389489000872 ABC transporter signature motif; other site 1389489000873 Walker B; other site 1389489000874 D-loop; other site 1389489000875 H-loop/switch region; other site 1389489000876 metabolite-proton symporter; Region: 2A0106; TIGR00883 1389489000877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489000878 putative substrate translocation pore; other site 1389489000879 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1389489000880 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1389489000881 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1389489000882 homopentamer interface [polypeptide binding]; other site 1389489000883 active site 1389489000884 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1389489000885 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1389489000886 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1389489000887 dimerization interface [polypeptide binding]; other site 1389489000888 active site 1389489000889 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1389489000890 Lumazine binding domain; Region: Lum_binding; pfam00677 1389489000891 Lumazine binding domain; Region: Lum_binding; pfam00677 1389489000892 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1389489000893 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1389489000894 catalytic motif [active] 1389489000895 Zn binding site [ion binding]; other site 1389489000896 RibD C-terminal domain; Region: RibD_C; pfam01872 1389489000897 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1389489000898 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1389489000899 DNA binding residues [nucleotide binding] 1389489000900 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1389489000901 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1389489000902 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1389489000903 amphipathic channel; other site 1389489000904 Asn-Pro-Ala signature motifs; other site 1389489000905 glycerol kinase; Provisional; Region: glpK; PRK00047 1389489000906 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1389489000907 N- and C-terminal domain interface [polypeptide binding]; other site 1389489000908 active site 1389489000909 MgATP binding site [chemical binding]; other site 1389489000910 catalytic site [active] 1389489000911 metal binding site [ion binding]; metal-binding site 1389489000912 putative homotetramer interface [polypeptide binding]; other site 1389489000913 glycerol binding site [chemical binding]; other site 1389489000914 homodimer interface [polypeptide binding]; other site 1389489000915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1389489000916 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1389489000917 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1389489000918 active site 1389489000919 HIGH motif; other site 1389489000920 dimer interface [polypeptide binding]; other site 1389489000921 KMSKS motif; other site 1389489000922 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1389489000923 putative active site [active] 1389489000924 putative catalytic site [active] 1389489000925 putative DNA binding site [nucleotide binding]; other site 1389489000926 putative phosphate binding site [ion binding]; other site 1389489000927 metal binding site A [ion binding]; metal-binding site 1389489000928 putative AP binding site [nucleotide binding]; other site 1389489000929 putative metal binding site B [ion binding]; other site 1389489000930 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1389489000931 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489000932 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1389489000933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1389489000934 catalytic loop [active] 1389489000935 iron binding site [ion binding]; other site 1389489000936 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1389489000937 L-aspartate oxidase; Provisional; Region: PRK06175 1389489000938 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1389489000939 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1389489000940 putative Iron-sulfur protein interface [polypeptide binding]; other site 1389489000941 putative proximal heme binding site [chemical binding]; other site 1389489000942 putative SdhC-like subunit interface [polypeptide binding]; other site 1389489000943 putative distal heme binding site [chemical binding]; other site 1389489000944 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1389489000945 putative Iron-sulfur protein interface [polypeptide binding]; other site 1389489000946 putative proximal heme binding site [chemical binding]; other site 1389489000947 putative SdhD-like interface [polypeptide binding]; other site 1389489000948 putative distal heme binding site [chemical binding]; other site 1389489000949 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1389489000950 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1389489000951 Substrate binding site; other site 1389489000952 Cupin domain; Region: Cupin_2; cl17218 1389489000953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489000954 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1389489000955 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1389489000956 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1389489000957 oligomer interface [polypeptide binding]; other site 1389489000958 metal binding site [ion binding]; metal-binding site 1389489000959 metal binding site [ion binding]; metal-binding site 1389489000960 putative Cl binding site [ion binding]; other site 1389489000961 basic sphincter; other site 1389489000962 hydrophobic gate; other site 1389489000963 periplasmic entrance; other site 1389489000964 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1389489000965 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1389489000966 ligand binding site [chemical binding]; other site 1389489000967 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1389489000968 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1389489000969 Walker A/P-loop; other site 1389489000970 ATP binding site [chemical binding]; other site 1389489000971 Q-loop/lid; other site 1389489000972 ABC transporter signature motif; other site 1389489000973 Walker B; other site 1389489000974 D-loop; other site 1389489000975 H-loop/switch region; other site 1389489000976 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1389489000977 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1389489000978 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1389489000979 TM-ABC transporter signature motif; other site 1389489000980 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1389489000981 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1389489000982 TM-ABC transporter signature motif; other site 1389489000983 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1389489000984 active site 1389489000985 catalytic motif [active] 1389489000986 Zn binding site [ion binding]; other site 1389489000987 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1389489000988 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1389489000989 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1389489000990 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1389489000991 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1389489000992 adenosine deaminase; Provisional; Region: PRK09358 1389489000993 active site 1389489000994 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1389489000995 active site 1389489000996 phosphorylation site [posttranslational modification] 1389489000997 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1389489000998 active site 1389489000999 P-loop; other site 1389489001000 phosphorylation site [posttranslational modification] 1389489001001 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1389489001002 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1389489001003 active site 1389489001004 substrate binding site [chemical binding]; other site 1389489001005 metal binding site [ion binding]; metal-binding site 1389489001006 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1389489001007 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1389489001008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1389489001009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1389489001010 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1389489001011 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1389489001012 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1389489001013 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1389489001014 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1389489001015 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1389489001016 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1389489001017 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1389489001018 carboxyltransferase (CT) interaction site; other site 1389489001019 biotinylation site [posttranslational modification]; other site 1389489001020 Maf-like protein; Region: Maf; pfam02545 1389489001021 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1389489001022 active site 1389489001023 dimer interface [polypeptide binding]; other site 1389489001024 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1389489001025 TRAM domain; Region: TRAM; cl01282 1389489001026 transcriptional regulator NarP; Provisional; Region: PRK10403 1389489001027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001028 active site 1389489001029 phosphorylation site [posttranslational modification] 1389489001030 intermolecular recognition site; other site 1389489001031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489001032 DNA binding residues [nucleotide binding] 1389489001033 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1389489001034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489001035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489001036 ATP binding site [chemical binding]; other site 1389489001037 Mg2+ binding site [ion binding]; other site 1389489001038 G-X-G motif; other site 1389489001039 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1389489001040 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1389489001041 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1389489001042 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1389489001043 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1389489001044 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1389489001045 Bacterial PH domain; Region: DUF304; pfam03703 1389489001046 Predicted membrane protein [Function unknown]; Region: COG2246 1389489001047 GtrA-like protein; Region: GtrA; pfam04138 1389489001048 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1389489001049 ATP-grasp domain; Region: ATP-grasp; pfam02222 1389489001050 AIR carboxylase; Region: AIRC; pfam00731 1389489001051 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1389489001052 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1389489001053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489001054 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1389489001055 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1389489001056 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1389489001057 NADP binding site [chemical binding]; other site 1389489001058 active site 1389489001059 putative substrate binding site [chemical binding]; other site 1389489001060 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1389489001061 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1389489001062 NAD binding site [chemical binding]; other site 1389489001063 substrate binding site [chemical binding]; other site 1389489001064 homodimer interface [polypeptide binding]; other site 1389489001065 active site 1389489001066 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1389489001067 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1389489001068 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1389489001069 substrate binding site; other site 1389489001070 tetramer interface; other site 1389489001071 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1389489001072 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1389489001073 Probable Catalytic site; other site 1389489001074 metal-binding site 1389489001075 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 1389489001076 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1389489001077 putative NAD(P) binding site [chemical binding]; other site 1389489001078 active site 1389489001079 putative substrate binding site [chemical binding]; other site 1389489001080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1389489001081 active site 1389489001082 Protein of unknown function (DUF616); Region: DUF616; pfam04765 1389489001083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489001084 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1389489001085 NAD(P) binding site [chemical binding]; other site 1389489001086 active site 1389489001087 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1389489001088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1389489001089 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001090 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1389489001091 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1389489001092 Walker A/P-loop; other site 1389489001093 ATP binding site [chemical binding]; other site 1389489001094 Q-loop/lid; other site 1389489001095 ABC transporter signature motif; other site 1389489001096 Walker B; other site 1389489001097 D-loop; other site 1389489001098 H-loop/switch region; other site 1389489001099 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1389489001100 putative carbohydrate binding site [chemical binding]; other site 1389489001101 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1389489001102 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1389489001103 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1389489001104 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489001105 active site 1389489001106 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1389489001107 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1389489001108 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1389489001109 active site 1389489001110 homodimer interface [polypeptide binding]; other site 1389489001111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489001112 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1389489001113 NAD(P) binding site [chemical binding]; other site 1389489001114 active site 1389489001115 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1389489001116 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1389489001117 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1389489001118 NADP binding site [chemical binding]; other site 1389489001119 active site 1389489001120 putative substrate binding site [chemical binding]; other site 1389489001121 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1389489001122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489001123 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1389489001124 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1389489001125 Ligand binding site; other site 1389489001126 Putative Catalytic site; other site 1389489001127 DXD motif; other site 1389489001128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1389489001129 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1389489001130 Probable Catalytic site; other site 1389489001131 Integrase core domain; Region: rve; pfam00665 1389489001132 Integrase core domain; Region: rve_3; pfam13683 1389489001133 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1389489001134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489001135 non-specific DNA binding site [nucleotide binding]; other site 1389489001136 salt bridge; other site 1389489001137 sequence-specific DNA binding site [nucleotide binding]; other site 1389489001138 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1389489001139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489001140 non-specific DNA binding site [nucleotide binding]; other site 1389489001141 salt bridge; other site 1389489001142 sequence-specific DNA binding site [nucleotide binding]; other site 1389489001143 pantothenate kinase; Provisional; Region: PRK05439 1389489001144 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1389489001145 ATP-binding site [chemical binding]; other site 1389489001146 CoA-binding site [chemical binding]; other site 1389489001147 Mg2+-binding site [ion binding]; other site 1389489001148 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1389489001149 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1389489001150 glutaminase active site [active] 1389489001151 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1389489001152 dimer interface [polypeptide binding]; other site 1389489001153 active site 1389489001154 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1389489001155 dimer interface [polypeptide binding]; other site 1389489001156 active site 1389489001157 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1389489001158 alanine racemase; Reviewed; Region: alr; PRK00053 1389489001159 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1389489001160 active site 1389489001161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1389489001162 dimer interface [polypeptide binding]; other site 1389489001163 substrate binding site [chemical binding]; other site 1389489001164 catalytic residues [active] 1389489001165 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1389489001166 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1389489001167 Glycoprotease family; Region: Peptidase_M22; pfam00814 1389489001168 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1389489001169 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1389489001170 UGMP family protein; Validated; Region: PRK09604 1389489001171 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1389489001172 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1389489001173 oligomerisation interface [polypeptide binding]; other site 1389489001174 mobile loop; other site 1389489001175 roof hairpin; other site 1389489001176 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1389489001177 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1389489001178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1389489001179 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1389489001180 active site 1389489001181 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1389489001182 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1389489001183 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1389489001184 active site 1389489001185 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1389489001186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1389489001187 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1389489001188 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1389489001189 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1389489001190 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 1389489001191 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1389489001192 GMP synthase; Reviewed; Region: guaA; PRK00074 1389489001193 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1389489001194 AMP/PPi binding site [chemical binding]; other site 1389489001195 candidate oxyanion hole; other site 1389489001196 catalytic triad [active] 1389489001197 potential glutamine specificity residues [chemical binding]; other site 1389489001198 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1389489001199 ATP Binding subdomain [chemical binding]; other site 1389489001200 Ligand Binding sites [chemical binding]; other site 1389489001201 Dimerization subdomain; other site 1389489001202 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1389489001203 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1389489001204 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1389489001205 active site 1389489001206 catalytic site [active] 1389489001207 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1389489001208 Part of AAA domain; Region: AAA_19; pfam13245 1389489001209 glycoprotein BALF4; Provisional; Region: PHA03231 1389489001210 Family description; Region: UvrD_C_2; pfam13538 1389489001211 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1389489001212 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1389489001213 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1389489001214 CoA-ligase; Region: Ligase_CoA; pfam00549 1389489001215 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1389489001216 CoA binding domain; Region: CoA_binding; smart00881 1389489001217 CoA-ligase; Region: Ligase_CoA; pfam00549 1389489001218 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1389489001219 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1389489001220 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1389489001221 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1389489001222 active site 1389489001223 substrate binding site [chemical binding]; other site 1389489001224 cosubstrate binding site; other site 1389489001225 catalytic site [active] 1389489001226 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1389489001227 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1389489001228 purine monophosphate binding site [chemical binding]; other site 1389489001229 dimer interface [polypeptide binding]; other site 1389489001230 putative catalytic residues [active] 1389489001231 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1389489001232 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1389489001233 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1389489001234 Amidinotransferase; Region: Amidinotransf; cl12043 1389489001235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489001236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001237 active site 1389489001238 phosphorylation site [posttranslational modification] 1389489001239 intermolecular recognition site; other site 1389489001240 dimerization interface [polypeptide binding]; other site 1389489001241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489001242 DNA binding residues [nucleotide binding] 1389489001243 dimerization interface [polypeptide binding]; other site 1389489001244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489001245 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1389489001246 DNA binding site [nucleotide binding] 1389489001247 active site 1389489001248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1389489001249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1389489001250 Coenzyme A binding pocket [chemical binding]; other site 1389489001251 isocitrate dehydrogenase; Validated; Region: PRK08299 1389489001252 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1389489001253 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1389489001254 active site 1389489001255 trimer interface [polypeptide binding]; other site 1389489001256 allosteric site; other site 1389489001257 active site lid [active] 1389489001258 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1389489001259 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1389489001260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1389489001261 Integrase core domain; Region: rve; pfam00665 1389489001262 Integrase core domain; Region: rve_3; pfam13683 1389489001263 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1389489001264 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1389489001265 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1389489001266 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1389489001267 putative active site [active] 1389489001268 putative substrate binding site [chemical binding]; other site 1389489001269 putative cosubstrate binding site; other site 1389489001270 catalytic site [active] 1389489001271 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1389489001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489001273 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1389489001274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1389489001275 Putative zinc-finger; Region: zf-HC2; pfam13490 1389489001276 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1389489001277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1389489001278 active site 1389489001279 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1389489001280 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1389489001281 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1389489001282 intersubunit interface [polypeptide binding]; other site 1389489001283 active site 1389489001284 zinc binding site [ion binding]; other site 1389489001285 Na+ binding site [ion binding]; other site 1389489001286 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489001287 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1389489001288 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1389489001289 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1389489001290 dimer interface [polypeptide binding]; other site 1389489001291 active site 1389489001292 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1389489001293 dimer interface [polypeptide binding]; other site 1389489001294 active site 1389489001295 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1389489001296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489001297 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489001298 DNA binding residues [nucleotide binding] 1389489001299 dimerization interface [polypeptide binding]; other site 1389489001300 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1389489001301 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1389489001302 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1389489001303 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1389489001304 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1389489001305 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1389489001306 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1389489001307 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489001308 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1389489001309 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1389489001310 active site 1389489001311 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1389489001312 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1389489001313 dimer interface [polypeptide binding]; other site 1389489001314 active site 1389489001315 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1389489001316 folate binding site [chemical binding]; other site 1389489001317 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1389489001318 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1389489001319 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1389489001320 homodimer interface [polypeptide binding]; other site 1389489001321 NADP binding site [chemical binding]; other site 1389489001322 substrate binding site [chemical binding]; other site 1389489001323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1389489001324 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001325 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1389489001326 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1389489001327 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1389489001328 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1389489001329 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1389489001330 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1389489001331 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1389489001332 nucleotide binding site/active site [active] 1389489001333 HIT family signature motif; other site 1389489001334 catalytic residue [active] 1389489001335 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1389489001336 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1389489001337 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1389489001338 O-Antigen ligase; Region: Wzy_C; pfam04932 1389489001339 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1389489001340 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1389489001341 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1389489001342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1389489001343 acyl-coenzyme A oxidase; Region: PLN02526 1389489001344 active site 1389489001345 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1389489001346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489001347 NAD(P) binding site [chemical binding]; other site 1389489001348 active site 1389489001349 Transcription factor WhiB; Region: Whib; pfam02467 1389489001350 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1389489001351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489001352 active site 1389489001353 Integrase core domain; Region: rve; pfam00665 1389489001354 Integrase core domain; Region: rve_3; pfam13683 1389489001355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489001356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489001357 DNA binding site [nucleotide binding] 1389489001358 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1389489001359 heme-binding site [chemical binding]; other site 1389489001360 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1389489001361 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1389489001362 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1389489001363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1389489001364 catalytic core [active] 1389489001365 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1389489001366 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1389489001367 PhoU domain; Region: PhoU; pfam01895 1389489001368 PhoU domain; Region: PhoU; pfam01895 1389489001369 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1389489001370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1389489001371 dimer interface [polypeptide binding]; other site 1389489001372 phosphorylation site [posttranslational modification] 1389489001373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489001374 ATP binding site [chemical binding]; other site 1389489001375 Mg2+ binding site [ion binding]; other site 1389489001376 G-X-G motif; other site 1389489001377 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489001378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001379 active site 1389489001380 phosphorylation site [posttranslational modification] 1389489001381 intermolecular recognition site; other site 1389489001382 dimerization interface [polypeptide binding]; other site 1389489001383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489001384 DNA binding site [nucleotide binding] 1389489001385 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1389489001386 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1389489001387 substrate binding site; other site 1389489001388 dimer interface; other site 1389489001389 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1389489001390 homotrimer interaction site [polypeptide binding]; other site 1389489001391 zinc binding site [ion binding]; other site 1389489001392 CDP-binding sites; other site 1389489001393 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1389489001394 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1389489001395 active site 1389489001396 HIGH motif; other site 1389489001397 nucleotide binding site [chemical binding]; other site 1389489001398 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1389489001399 KMSKS motif; other site 1389489001400 tRNA binding surface [nucleotide binding]; other site 1389489001401 anticodon binding site; other site 1389489001402 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 1389489001403 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1389489001404 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1389489001405 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1389489001406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489001407 Histidine kinase; Region: HisKA_3; pfam07730 1389489001408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489001409 ATP binding site [chemical binding]; other site 1389489001410 Mg2+ binding site [ion binding]; other site 1389489001411 G-X-G motif; other site 1389489001412 Response regulator receiver domain; Region: Response_reg; pfam00072 1389489001413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001414 active site 1389489001415 phosphorylation site [posttranslational modification] 1389489001416 intermolecular recognition site; other site 1389489001417 dimerization interface [polypeptide binding]; other site 1389489001418 Domain of unknown function (DUF336); Region: DUF336; cl01249 1389489001419 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1389489001420 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1389489001421 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1389489001422 Walker A/P-loop; other site 1389489001423 ATP binding site [chemical binding]; other site 1389489001424 Q-loop/lid; other site 1389489001425 ABC transporter signature motif; other site 1389489001426 Walker B; other site 1389489001427 D-loop; other site 1389489001428 H-loop/switch region; other site 1389489001429 TOBE domain; Region: TOBE_2; pfam08402 1389489001430 Thioredoxin; Region: Thioredoxin_4; cl17273 1389489001431 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1389489001432 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1389489001433 Citrate transporter; Region: CitMHS; pfam03600 1389489001434 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1389489001435 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1389489001436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489001437 ATP binding site [chemical binding]; other site 1389489001438 Mg2+ binding site [ion binding]; other site 1389489001439 G-X-G motif; other site 1389489001440 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1389489001441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001442 active site 1389489001443 dimerization interface [polypeptide binding]; other site 1389489001444 YCII-related domain; Region: YCII; cl00999 1389489001445 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1389489001446 NAD binding pocket [chemical binding]; other site 1389489001447 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1389489001448 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1389489001449 Catalytic site [active] 1389489001450 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1389489001451 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1389489001452 putative FMN binding site [chemical binding]; other site 1389489001453 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1389489001454 SelR domain; Region: SelR; pfam01641 1389489001455 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1389489001456 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1389489001457 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1389489001458 DNA-binding site [nucleotide binding]; DNA binding site 1389489001459 RNA-binding motif; other site 1389489001460 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1389489001461 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1389489001462 ring oligomerisation interface [polypeptide binding]; other site 1389489001463 ATP/Mg binding site [chemical binding]; other site 1389489001464 stacking interactions; other site 1389489001465 hinge regions; other site 1389489001466 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1389489001468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1389489001469 dimerization interface [polypeptide binding]; other site 1389489001470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1389489001471 dimer interface [polypeptide binding]; other site 1389489001472 phosphorylation site [posttranslational modification] 1389489001473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1389489001474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489001475 ATP binding site [chemical binding]; other site 1389489001476 Mg2+ binding site [ion binding]; other site 1389489001477 G-X-G motif; other site 1389489001478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489001479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001480 active site 1389489001481 phosphorylation site [posttranslational modification] 1389489001482 intermolecular recognition site; other site 1389489001483 dimerization interface [polypeptide binding]; other site 1389489001484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489001485 DNA binding site [nucleotide binding] 1389489001486 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1389489001487 dihydropteroate synthase; Region: DHPS; TIGR01496 1389489001488 substrate binding pocket [chemical binding]; other site 1389489001489 dimer interface [polypeptide binding]; other site 1389489001490 inhibitor binding site; inhibition site 1389489001491 hypothetical protein; Provisional; Region: PRK14059 1389489001492 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1389489001493 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1389489001494 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1389489001495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489001496 ATP binding site [chemical binding]; other site 1389489001497 putative Mg++ binding site [ion binding]; other site 1389489001498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489001499 nucleotide binding region [chemical binding]; other site 1389489001500 ATP-binding site [chemical binding]; other site 1389489001501 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1389489001502 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1389489001503 DNA-binding site [nucleotide binding]; DNA binding site 1389489001504 RNA-binding motif; other site 1389489001505 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1389489001506 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1389489001507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489001508 catalytic residue [active] 1389489001509 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1389489001510 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1389489001511 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1389489001512 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1389489001513 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1389489001514 NlpC/P60 family; Region: NLPC_P60; pfam00877 1389489001515 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1389489001516 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1389489001517 active site 1389489001518 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1389489001519 Catalytic site [active] 1389489001520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1389489001521 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1389489001522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1389489001523 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 1389489001524 ATP cone domain; Region: ATP-cone; pfam03477 1389489001525 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1389489001526 active site 1389489001527 dimer interface [polypeptide binding]; other site 1389489001528 catalytic residues [active] 1389489001529 effector binding site; other site 1389489001530 R2 peptide binding site; other site 1389489001531 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1389489001532 dimer interface [polypeptide binding]; other site 1389489001533 putative radical transfer pathway; other site 1389489001534 diiron center [ion binding]; other site 1389489001535 tyrosyl radical; other site 1389489001536 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1389489001537 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1389489001538 active site residue [active] 1389489001539 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1389489001540 active site residue [active] 1389489001541 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1389489001542 catalytic residue [active] 1389489001543 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1389489001544 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1389489001545 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1389489001546 tetramer interface [polypeptide binding]; other site 1389489001547 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1389489001548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489001549 dimer interface [polypeptide binding]; other site 1389489001550 conserved gate region; other site 1389489001551 putative PBP binding loops; other site 1389489001552 ABC-ATPase subunit interface; other site 1389489001553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1389489001554 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1389489001555 Walker A/P-loop; other site 1389489001556 ATP binding site [chemical binding]; other site 1389489001557 Q-loop/lid; other site 1389489001558 ABC transporter signature motif; other site 1389489001559 Walker B; other site 1389489001560 D-loop; other site 1389489001561 H-loop/switch region; other site 1389489001562 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 1389489001563 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1389489001564 active site 1 [active] 1389489001565 dimer interface [polypeptide binding]; other site 1389489001566 hexamer interface [polypeptide binding]; other site 1389489001567 active site 2 [active] 1389489001568 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1389489001569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489001570 ATP binding site [chemical binding]; other site 1389489001571 putative Mg++ binding site [ion binding]; other site 1389489001572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489001573 nucleotide binding region [chemical binding]; other site 1389489001574 ATP-binding site [chemical binding]; other site 1389489001575 Helicase associated domain (HA2); Region: HA2; pfam04408 1389489001576 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1389489001577 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1389489001578 Integrase core domain; Region: rve; pfam00665 1389489001579 Integrase core domain; Region: rve_3; pfam13683 1389489001580 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1389489001581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1389489001582 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1389489001583 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1389489001584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489001585 active site 1389489001586 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1389489001587 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1389489001588 Substrate binding site; other site 1389489001589 Mg++ binding site; other site 1389489001590 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1389489001591 active site 1389489001592 substrate binding site [chemical binding]; other site 1389489001593 CoA binding site [chemical binding]; other site 1389489001594 MarR family; Region: MarR_2; cl17246 1389489001595 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1389489001596 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1389489001597 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1389489001598 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1389489001599 putative ADP-binding pocket [chemical binding]; other site 1389489001600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489001601 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1389489001602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489001603 Walker A/P-loop; other site 1389489001604 ATP binding site [chemical binding]; other site 1389489001605 Q-loop/lid; other site 1389489001606 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1389489001607 ABC transporter; Region: ABC_tran_2; pfam12848 1389489001608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489001609 Walker A/P-loop; other site 1389489001610 ATP binding site [chemical binding]; other site 1389489001611 Q-loop/lid; other site 1389489001612 Walker B; other site 1389489001613 D-loop; other site 1389489001614 H-loop/switch region; other site 1389489001615 AAA ATPase domain; Region: AAA_16; pfam13191 1389489001616 AAA domain; Region: AAA_22; pfam13401 1389489001617 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1389489001618 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1389489001619 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1389489001620 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1389489001621 active site 1389489001622 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1389489001623 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1389489001624 active site 1389489001625 HIGH motif; other site 1389489001626 KMSKS motif; other site 1389489001627 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1389489001628 tRNA binding surface [nucleotide binding]; other site 1389489001629 anticodon binding site; other site 1389489001630 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001631 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1389489001632 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1389489001633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489001634 catalytic residue [active] 1389489001635 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1389489001636 catalytic residues [active] 1389489001637 dimer interface [polypeptide binding]; other site 1389489001638 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1389489001639 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1389489001640 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1389489001641 putative active site [active] 1389489001642 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1389489001643 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1389489001644 putative active site [active] 1389489001645 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1389489001646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1389489001647 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1389489001648 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1389489001649 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1389489001650 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1389489001651 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1389489001652 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1389489001653 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1389489001654 Predicted methyltransferases [General function prediction only]; Region: COG0313 1389489001655 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1389489001656 putative SAM binding site [chemical binding]; other site 1389489001657 putative homodimer interface [polypeptide binding]; other site 1389489001658 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1389489001659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1389489001660 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001661 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1389489001662 NusA N-terminal domain; Region: NusA_N; pfam08529 1389489001663 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1389489001664 RNA binding site [nucleotide binding]; other site 1389489001665 homodimer interface [polypeptide binding]; other site 1389489001666 NusA-like KH domain; Region: KH_5; pfam13184 1389489001667 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1389489001668 G-X-X-G motif; other site 1389489001669 translation initiation factor IF-2; Region: IF-2; TIGR00487 1389489001670 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1389489001671 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1389489001672 G1 box; other site 1389489001673 putative GEF interaction site [polypeptide binding]; other site 1389489001674 GTP/Mg2+ binding site [chemical binding]; other site 1389489001675 Switch I region; other site 1389489001676 G2 box; other site 1389489001677 G3 box; other site 1389489001678 Switch II region; other site 1389489001679 G4 box; other site 1389489001680 G5 box; other site 1389489001681 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1389489001682 Translation-initiation factor 2; Region: IF-2; pfam11987 1389489001683 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1389489001684 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1389489001685 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1389489001686 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1389489001687 endonuclease III; Region: ENDO3c; smart00478 1389489001688 minor groove reading motif; other site 1389489001689 helix-hairpin-helix signature motif; other site 1389489001690 substrate binding pocket [chemical binding]; other site 1389489001691 active site 1389489001692 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1389489001693 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1389489001694 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1389489001695 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001696 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1389489001697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489001698 motif II; other site 1389489001699 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1389489001700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489001701 DNA-binding site [nucleotide binding]; DNA binding site 1389489001702 UTRA domain; Region: UTRA; pfam07702 1389489001703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1389489001704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489001705 putative PBP binding loops; other site 1389489001706 ABC-ATPase subunit interface; other site 1389489001707 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1389489001708 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1389489001709 RNA binding site [nucleotide binding]; other site 1389489001710 active site 1389489001711 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1389489001712 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1389489001713 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1389489001714 active site 1389489001715 Riboflavin kinase; Region: Flavokinase; pfam01687 1389489001716 cyanate transporter; Region: CynX; TIGR00896 1389489001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489001718 putative substrate translocation pore; other site 1389489001719 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1389489001720 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1389489001721 intersubunit interface [polypeptide binding]; other site 1389489001722 active site 1389489001723 catalytic residue [active] 1389489001724 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489001725 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1389489001726 NAD(P) binding site [chemical binding]; other site 1389489001727 catalytic residues [active] 1389489001728 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489001729 NAD(P) binding site [chemical binding]; other site 1389489001730 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1389489001731 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1389489001732 intersubunit interface [polypeptide binding]; other site 1389489001733 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1389489001734 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1389489001735 ABC-ATPase subunit interface; other site 1389489001736 dimer interface [polypeptide binding]; other site 1389489001737 putative PBP binding regions; other site 1389489001738 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1389489001739 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1389489001740 Walker A/P-loop; other site 1389489001741 ATP binding site [chemical binding]; other site 1389489001742 Q-loop/lid; other site 1389489001743 ABC transporter signature motif; other site 1389489001744 Walker B; other site 1389489001745 D-loop; other site 1389489001746 H-loop/switch region; other site 1389489001747 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1389489001748 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 1389489001749 active site 1389489001750 catalytic triad [active] 1389489001751 oxyanion hole [active] 1389489001752 RNase III inhibitor; Provisional; Region: PRK00431 1389489001753 ADP-ribose binding site [chemical binding]; other site 1389489001754 putative homodimer interface [polypeptide binding]; other site 1389489001755 putative homotetramer interface [polypeptide binding]; other site 1389489001756 Metal-sensitive transcriptional repressor; Region: Trns_repr_metal; pfam02583 1389489001757 putative allosteric switch controlling residues; other site 1389489001758 putative metal binding site [ion binding]; other site 1389489001759 putative homodimer-homodimer interface [polypeptide binding]; other site 1389489001760 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1389489001761 metal-binding site [ion binding] 1389489001762 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1389489001763 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1389489001764 metal-binding site [ion binding] 1389489001765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1389489001766 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1389489001767 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1389489001768 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1389489001769 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1389489001770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489001771 ATP binding site [chemical binding]; other site 1389489001772 putative Mg++ binding site [ion binding]; other site 1389489001773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489001774 nucleotide binding region [chemical binding]; other site 1389489001775 ATP-binding site [chemical binding]; other site 1389489001776 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489001777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001778 active site 1389489001779 phosphorylation site [posttranslational modification] 1389489001780 intermolecular recognition site; other site 1389489001781 dimerization interface [polypeptide binding]; other site 1389489001782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489001783 dimerization interface [polypeptide binding]; other site 1389489001784 DNA binding residues [nucleotide binding] 1389489001785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489001786 Histidine kinase; Region: HisKA_3; pfam07730 1389489001787 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1389489001788 ATP binding site [chemical binding]; other site 1389489001789 Mg2+ binding site [ion binding]; other site 1389489001790 G-X-G motif; other site 1389489001791 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1389489001792 putative active site; other site 1389489001793 putative metal binding residues [ion binding]; other site 1389489001794 signature motif; other site 1389489001795 putative triphosphate binding site [ion binding]; other site 1389489001796 phosphofructokinase; Region: PFK_mixed; TIGR02483 1389489001797 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1389489001798 active site 1389489001799 ADP/pyrophosphate binding site [chemical binding]; other site 1389489001800 dimerization interface [polypeptide binding]; other site 1389489001801 allosteric effector site; other site 1389489001802 fructose-1,6-bisphosphate binding site; other site 1389489001803 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1389489001804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489001805 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489001806 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489001807 Integrase core domain; Region: rve; pfam00665 1389489001808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489001809 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1389489001810 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1389489001811 active site 1389489001812 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489001813 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489001814 active site 1389489001815 Int/Topo IB signature motif; other site 1389489001816 DNA binding site [nucleotide binding] 1389489001817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489001818 ATP binding site [chemical binding]; other site 1389489001819 putative Mg++ binding site [ion binding]; other site 1389489001820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489001821 nucleotide binding region [chemical binding]; other site 1389489001822 ATP-binding site [chemical binding]; other site 1389489001823 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1389489001824 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1389489001825 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1389489001826 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1389489001827 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1389489001828 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1389489001829 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1389489001830 Aspartase; Region: Aspartase; cd01357 1389489001831 active sites [active] 1389489001832 tetramer interface [polypeptide binding]; other site 1389489001833 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1389489001834 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1389489001835 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1389489001836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1389489001837 active site 1389489001838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489001839 FAD binding domain; Region: FAD_binding_4; pfam01565 1389489001840 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1389489001841 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1389489001842 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1389489001843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489001844 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1389489001845 16S/18S rRNA binding site [nucleotide binding]; other site 1389489001846 S13e-L30e interaction site [polypeptide binding]; other site 1389489001847 25S rRNA binding site [nucleotide binding]; other site 1389489001848 VanZ like family; Region: VanZ; cl01971 1389489001849 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1389489001850 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1389489001851 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1389489001852 Integrase core domain; Region: rve; pfam00665 1389489001853 Integrase core domain; Region: rve_3; pfam13683 1389489001854 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1389489001856 non-specific DNA binding site [nucleotide binding]; other site 1389489001857 salt bridge; other site 1389489001858 sequence-specific DNA binding site [nucleotide binding]; other site 1389489001859 Helix-turn-helix domain; Region: HTH_19; pfam12844 1389489001860 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1389489001861 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489001862 active site 1389489001863 DNA binding site [nucleotide binding] 1389489001864 Int/Topo IB signature motif; other site 1389489001865 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489001866 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489001867 Integrase core domain; Region: rve; pfam00665 1389489001868 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1389489001869 Integrase core domain; Region: rve; pfam00665 1389489001870 Integrase core domain; Region: rve_3; pfam13683 1389489001871 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1389489001872 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1389489001873 oligomer interface [polypeptide binding]; other site 1389489001874 RNA binding site [nucleotide binding]; other site 1389489001875 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1389489001876 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1389489001877 RNase E interface [polypeptide binding]; other site 1389489001878 trimer interface [polypeptide binding]; other site 1389489001879 active site 1389489001880 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1389489001881 putative nucleic acid binding region [nucleotide binding]; other site 1389489001882 G-X-X-G motif; other site 1389489001883 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1389489001884 RNA binding site [nucleotide binding]; other site 1389489001885 domain interface; other site 1389489001886 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1389489001887 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1389489001888 putative trimer interface [polypeptide binding]; other site 1389489001889 putative CoA binding site [chemical binding]; other site 1389489001890 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1389489001891 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1389489001892 metal binding site [ion binding]; metal-binding site 1389489001893 putative dimer interface [polypeptide binding]; other site 1389489001894 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1389489001895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489001896 S-adenosylmethionine binding site [chemical binding]; other site 1389489001897 sec-independent translocase; Provisional; Region: PRK01371 1389489001898 Domain of unknown function DUF59; Region: DUF59; cl00941 1389489001899 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1389489001900 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1389489001901 Walker A motif; other site 1389489001902 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1389489001903 MgtE intracellular N domain; Region: MgtE_N; smart00924 1389489001904 FOG: CBS domain [General function prediction only]; Region: COG0517 1389489001905 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1389489001906 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1389489001907 proline aminopeptidase P II; Provisional; Region: PRK10879 1389489001908 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1389489001909 active site 1389489001910 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1389489001911 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1389489001912 active site 1389489001913 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1389489001914 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1389489001915 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1389489001916 catalytic residue [active] 1389489001917 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1389489001918 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1389489001919 ATP binding site [chemical binding]; other site 1389489001920 Mg++ binding site [ion binding]; other site 1389489001921 motif III; other site 1389489001922 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489001923 nucleotide binding region [chemical binding]; other site 1389489001924 ATP-binding site [chemical binding]; other site 1389489001925 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1389489001926 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1389489001927 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1389489001928 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1389489001929 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1389489001930 Part of AAA domain; Region: AAA_19; pfam13245 1389489001931 Family description; Region: UvrD_C_2; pfam13538 1389489001932 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1389489001933 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1389489001934 Predicted transcriptional regulators [Transcription]; Region: COG1733 1389489001935 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1389489001936 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1389489001937 active site 1389489001938 ATP binding site [chemical binding]; other site 1389489001939 Phosphotransferase enzyme family; Region: APH; pfam01636 1389489001940 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1389489001941 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1389489001942 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1389489001943 putative NADH binding site [chemical binding]; other site 1389489001944 putative active site [active] 1389489001945 nudix motif; other site 1389489001946 putative metal binding site [ion binding]; other site 1389489001947 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1389489001948 Part of AAA domain; Region: AAA_19; pfam13245 1389489001949 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1389489001950 Family description; Region: UvrD_C_2; pfam13538 1389489001951 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1389489001952 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1389489001953 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1389489001954 protein binding site [polypeptide binding]; other site 1389489001955 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1389489001956 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1389489001957 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1389489001958 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1389489001959 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1389489001960 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1389489001961 active site 1389489001962 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1389489001963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489001964 active site 1389489001965 phosphorylation site [posttranslational modification] 1389489001966 intermolecular recognition site; other site 1389489001967 dimerization interface [polypeptide binding]; other site 1389489001968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1389489001969 PAS domain; Region: PAS_9; pfam13426 1389489001970 putative active site [active] 1389489001971 heme pocket [chemical binding]; other site 1389489001972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1389489001973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1389489001974 dimer interface [polypeptide binding]; other site 1389489001975 phosphorylation site [posttranslational modification] 1389489001976 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1389489001977 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1389489001978 putative active site [active] 1389489001979 catalytic triad [active] 1389489001980 putative dimer interface [polypeptide binding]; other site 1389489001981 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1389489001982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489001983 active site 1389489001984 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1389489001985 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1389489001986 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 1389489001987 Ligand binding site; other site 1389489001988 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1389489001989 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1389489001990 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1389489001991 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489001992 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1389489001993 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1389489001994 Walker A/P-loop; other site 1389489001995 ATP binding site [chemical binding]; other site 1389489001996 Q-loop/lid; other site 1389489001997 ABC transporter signature motif; other site 1389489001998 Walker B; other site 1389489001999 D-loop; other site 1389489002000 H-loop/switch region; other site 1389489002001 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1389489002002 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1389489002003 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1389489002004 active site 1389489002005 metal-binding site 1389489002006 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1389489002007 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1389489002008 Walker A/P-loop; other site 1389489002009 ATP binding site [chemical binding]; other site 1389489002010 Q-loop/lid; other site 1389489002011 ABC transporter signature motif; other site 1389489002012 Walker B; other site 1389489002013 D-loop; other site 1389489002014 H-loop/switch region; other site 1389489002015 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1389489002016 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1389489002017 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1389489002018 active site 1389489002019 glutamate racemase; Provisional; Region: PRK00865 1389489002020 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1389489002021 ribonuclease PH; Reviewed; Region: rph; PRK00173 1389489002022 hexamer interface [polypeptide binding]; other site 1389489002023 active site 1389489002024 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1389489002025 active site 1389489002026 dimerization interface [polypeptide binding]; other site 1389489002027 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1389489002028 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1389489002029 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1389489002030 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1389489002031 RF-1 domain; Region: RF-1; pfam00472 1389489002032 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1389489002033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489002034 Walker A/P-loop; other site 1389489002035 ATP binding site [chemical binding]; other site 1389489002036 Q-loop/lid; other site 1389489002037 ABC transporter signature motif; other site 1389489002038 Walker B; other site 1389489002039 D-loop; other site 1389489002040 H-loop/switch region; other site 1389489002041 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1389489002042 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1389489002043 FtsX-like permease family; Region: FtsX; pfam02687 1389489002044 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1389489002045 SmpB-tmRNA interface; other site 1389489002046 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1389489002047 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1389489002048 Integrase core domain; Region: rve; pfam00665 1389489002049 Integrase core domain; Region: rve_3; pfam13683 1389489002050 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1389489002051 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1389489002052 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1389489002053 active site 1389489002054 purine riboside binding site [chemical binding]; other site 1389489002055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489002056 Walker B; other site 1389489002057 D-loop; other site 1389489002058 H-loop/switch region; other site 1389489002059 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1389489002060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1389489002061 dimerization interface [polypeptide binding]; other site 1389489002062 putative DNA binding site [nucleotide binding]; other site 1389489002063 putative Zn2+ binding site [ion binding]; other site 1389489002064 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1389489002065 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1389489002066 active site 1389489002067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489002068 sequence-specific DNA binding site [nucleotide binding]; other site 1389489002069 salt bridge; other site 1389489002070 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1389489002071 Integrase core domain; Region: rve; pfam00665 1389489002072 Integrase core domain; Region: rve_3; pfam13683 1389489002073 Integrase core domain; Region: rve; pfam00665 1389489002074 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489002075 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489002076 Integrase core domain; Region: rve; pfam00665 1389489002077 Dodecin; Region: Dodecin; pfam07311 1389489002078 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1389489002079 GAF domain; Region: GAF; pfam01590 1389489002080 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1389489002081 GAF domain; Region: GAF_3; pfam13492 1389489002082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489002083 Histidine kinase; Region: HisKA_3; pfam07730 1389489002084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489002085 ATP binding site [chemical binding]; other site 1389489002086 Mg2+ binding site [ion binding]; other site 1389489002087 G-X-G motif; other site 1389489002088 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1389489002089 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1389489002090 putative NAD(P) binding site [chemical binding]; other site 1389489002091 putative substrate binding site [chemical binding]; other site 1389489002092 catalytic Zn binding site [ion binding]; other site 1389489002093 structural Zn binding site [ion binding]; other site 1389489002094 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1389489002095 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1389489002096 classical (c) SDRs; Region: SDR_c; cd05233 1389489002097 NAD(P) binding site [chemical binding]; other site 1389489002098 active site 1389489002099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489002100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489002101 active site 1389489002102 phosphorylation site [posttranslational modification] 1389489002103 intermolecular recognition site; other site 1389489002104 dimerization interface [polypeptide binding]; other site 1389489002105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489002106 DNA binding residues [nucleotide binding] 1389489002107 dimerization interface [polypeptide binding]; other site 1389489002108 TM2 domain; Region: TM2; pfam05154 1389489002109 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1389489002110 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1389489002111 putative substrate binding site [chemical binding]; other site 1389489002112 nucleotide binding site [chemical binding]; other site 1389489002113 nucleotide binding site [chemical binding]; other site 1389489002114 homodimer interface [polypeptide binding]; other site 1389489002115 ornithine carbamoyltransferase; Validated; Region: PRK02102 1389489002116 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1389489002117 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1389489002118 Amidinotransferase; Region: Amidinotransf; cl12043 1389489002119 arginine:agmatin antiporter; Provisional; Region: PRK10644 1389489002120 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489002121 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489002122 Integrase core domain; Region: rve; pfam00665 1389489002123 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489002124 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1389489002125 NAD(P) binding site [chemical binding]; other site 1389489002126 catalytic residues [active] 1389489002127 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1389489002128 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1389489002129 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1389489002130 NAD binding site [chemical binding]; other site 1389489002131 Integrase core domain; Region: rve; pfam00665 1389489002132 Integrase core domain; Region: rve_3; pfam13683 1389489002133 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1389489002134 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1389489002135 NAD binding site [chemical binding]; other site 1389489002136 substrate binding site [chemical binding]; other site 1389489002137 catalytic Zn binding site [ion binding]; other site 1389489002138 tetramer interface [polypeptide binding]; other site 1389489002139 structural Zn binding site [ion binding]; other site 1389489002140 transposase/IS protein; Provisional; Region: PRK09183 1389489002141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489002142 Walker A motif; other site 1389489002143 ATP binding site [chemical binding]; other site 1389489002144 Walker B motif; other site 1389489002145 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1389489002146 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1389489002147 catalytic residues [active] 1389489002148 catalytic nucleophile [active] 1389489002149 Presynaptic Site I dimer interface [polypeptide binding]; other site 1389489002150 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1389489002151 Synaptic Flat tetramer interface [polypeptide binding]; other site 1389489002152 Synaptic Site I dimer interface [polypeptide binding]; other site 1389489002153 DNA binding site [nucleotide binding] 1389489002154 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1389489002155 DNA-binding interface [nucleotide binding]; DNA binding site 1389489002156 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1389489002157 Fic/DOC family; Region: Fic; cl00960 1389489002158 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1389489002159 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1389489002160 catalytic residues [active] 1389489002161 catalytic nucleophile [active] 1389489002162 Presynaptic Site I dimer interface [polypeptide binding]; other site 1389489002163 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1389489002164 Synaptic Flat tetramer interface [polypeptide binding]; other site 1389489002165 Synaptic Site I dimer interface [polypeptide binding]; other site 1389489002166 DNA binding site [nucleotide binding] 1389489002167 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1389489002168 DNA-binding interface [nucleotide binding]; DNA binding site 1389489002169 Integrase core domain; Region: rve; pfam00665 1389489002170 Integrase core domain; Region: rve_3; pfam13683 1389489002171 DNA photolyase; Region: DNA_photolyase; pfam00875 1389489002172 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1389489002173 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1389489002174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1389489002175 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1389489002176 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489002177 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489002178 Integrase core domain; Region: rve; pfam00665 1389489002179 Integrase core domain; Region: rve; pfam00665 1389489002180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489002181 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489002182 DNA binding residues [nucleotide binding] 1389489002183 dimerization interface [polypeptide binding]; other site 1389489002184 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1389489002185 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1389489002186 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1389489002187 Protein phosphatase 2C; Region: PP2C; pfam00481 1389489002188 active site 1389489002189 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1389489002190 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1389489002191 substrate binding site [chemical binding]; other site 1389489002192 ligand binding site [chemical binding]; other site 1389489002193 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1389489002194 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1389489002195 substrate binding site [chemical binding]; other site 1389489002196 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1389489002197 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1389489002198 hinge; other site 1389489002199 active site 1389489002200 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1389489002201 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1389489002202 putative acyl-acceptor binding pocket; other site 1389489002203 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1389489002204 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1389489002205 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1389489002206 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1389489002207 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1389489002208 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1389489002209 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1389489002210 thiamine monophosphate kinase; Provisional; Region: PRK05731 1389489002211 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1389489002212 ATP binding site [chemical binding]; other site 1389489002213 dimerization interface [polypeptide binding]; other site 1389489002214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1389489002215 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1389489002216 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1389489002217 generic binding surface II; other site 1389489002218 ssDNA binding site; other site 1389489002219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489002220 ATP binding site [chemical binding]; other site 1389489002221 putative Mg++ binding site [ion binding]; other site 1389489002222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489002223 nucleotide binding region [chemical binding]; other site 1389489002224 ATP-binding site [chemical binding]; other site 1389489002225 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1389489002226 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1389489002227 active site 1389489002228 (T/H)XGH motif; other site 1389489002229 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1389489002230 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1389489002231 ribonuclease III; Reviewed; Region: rnc; PRK00102 1389489002232 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1389489002233 dimerization interface [polypeptide binding]; other site 1389489002234 active site 1389489002235 metal binding site [ion binding]; metal-binding site 1389489002236 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1389489002237 dsRNA binding site [nucleotide binding]; other site 1389489002238 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1389489002239 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1389489002240 DNA binding site [nucleotide binding] 1389489002241 catalytic residue [active] 1389489002242 H2TH interface [polypeptide binding]; other site 1389489002243 putative catalytic residues [active] 1389489002244 turnover-facilitating residue; other site 1389489002245 intercalation triad [nucleotide binding]; other site 1389489002246 8OG recognition residue [nucleotide binding]; other site 1389489002247 putative reading head residues; other site 1389489002248 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1389489002249 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1389489002250 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1389489002251 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1389489002252 dimerization interface [polypeptide binding]; other site 1389489002253 ligand binding site [chemical binding]; other site 1389489002254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1389489002255 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1389489002256 TM-ABC transporter signature motif; other site 1389489002257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1389489002258 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1389489002259 Walker A/P-loop; other site 1389489002260 ATP binding site [chemical binding]; other site 1389489002261 Q-loop/lid; other site 1389489002262 ABC transporter signature motif; other site 1389489002263 Walker B; other site 1389489002264 D-loop; other site 1389489002265 H-loop/switch region; other site 1389489002266 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1389489002267 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1389489002268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489002269 catalytic residue [active] 1389489002270 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1389489002271 AAA domain; Region: AAA_23; pfam13476 1389489002272 Walker A/P-loop; other site 1389489002273 ATP binding site [chemical binding]; other site 1389489002274 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1389489002275 ABC transporter signature motif; other site 1389489002276 Walker B; other site 1389489002277 D-loop; other site 1389489002278 H-loop/switch region; other site 1389489002279 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1389489002280 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1389489002281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1389489002282 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 1389489002283 signal recognition particle protein; Provisional; Region: PRK10867 1389489002284 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1389489002285 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1389489002286 P loop; other site 1389489002287 GTP binding site [chemical binding]; other site 1389489002288 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1389489002289 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489002290 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489002291 Integrase core domain; Region: rve; pfam00665 1389489002292 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1389489002293 active site 1389489002294 catalytic triad [active] 1389489002295 oxyanion hole [active] 1389489002296 carboxylate-amine ligase; Provisional; Region: PRK13517 1389489002297 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1389489002298 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1389489002299 hypothetical protein; Provisional; Region: PRK02821 1389489002300 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1389489002301 G-X-X-G motif; other site 1389489002302 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1389489002303 RimM N-terminal domain; Region: RimM; pfam01782 1389489002304 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1389489002305 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1389489002306 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1389489002307 RNA/DNA hybrid binding site [nucleotide binding]; other site 1389489002308 active site 1389489002309 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1389489002310 hypothetical protein; Reviewed; Region: PRK12497 1389489002311 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1389489002312 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1389489002313 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1389489002314 DNA protecting protein DprA; Region: dprA; TIGR00732 1389489002315 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1389489002316 MarR family; Region: MarR_2; cl17246 1389489002317 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 1389489002318 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489002319 active site 1389489002320 DNA binding site [nucleotide binding] 1389489002321 Int/Topo IB signature motif; other site 1389489002322 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1389489002323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489002324 putative substrate translocation pore; other site 1389489002325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489002326 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1389489002327 rRNA interaction site [nucleotide binding]; other site 1389489002328 S8 interaction site; other site 1389489002329 putative laminin-1 binding site; other site 1389489002330 elongation factor Ts; Provisional; Region: tsf; PRK09377 1389489002331 UBA/TS-N domain; Region: UBA; pfam00627 1389489002332 Elongation factor TS; Region: EF_TS; pfam00889 1389489002333 Elongation factor TS; Region: EF_TS; pfam00889 1389489002334 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1389489002335 putative nucleotide binding site [chemical binding]; other site 1389489002336 uridine monophosphate binding site [chemical binding]; other site 1389489002337 homohexameric interface [polypeptide binding]; other site 1389489002338 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1389489002339 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1389489002340 hinge region; other site 1389489002341 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1389489002342 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1389489002343 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1389489002344 DivIVA domain; Region: DivI1A_domain; TIGR03544 1389489002345 DivIVA domain; Region: DivI1A_domain; TIGR03544 1389489002346 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1389489002347 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1389489002348 catalytic residue [active] 1389489002349 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1389489002350 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1389489002351 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1389489002352 DivIVA protein; Region: DivIVA; pfam05103 1389489002353 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 1389489002354 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1389489002355 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1389489002356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1389489002357 TPR motif; other site 1389489002358 binding surface 1389489002359 glycogen branching enzyme; Provisional; Region: PRK05402 1389489002360 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1389489002361 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1389489002362 active site 1389489002363 catalytic site [active] 1389489002364 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1389489002365 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1389489002366 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1389489002367 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1389489002368 active site 1389489002369 homodimer interface [polypeptide binding]; other site 1389489002370 catalytic site [active] 1389489002371 acceptor binding site [chemical binding]; other site 1389489002372 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1389489002373 active site 1389489002374 catalytic site [active] 1389489002375 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1389489002376 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1389489002377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489002378 catalytic residue [active] 1389489002379 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1389489002380 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1389489002381 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1389489002382 nucleotide binding pocket [chemical binding]; other site 1389489002383 K-X-D-G motif; other site 1389489002384 catalytic site [active] 1389489002385 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1389489002386 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1389489002387 Helix-hairpin-helix motif; Region: HHH; pfam00633 1389489002388 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1389489002389 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1389489002390 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1389489002391 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1389489002392 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1389489002393 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1389489002394 GatB domain; Region: GatB_Yqey; smart00845 1389489002395 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 1389489002396 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1389489002397 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1389489002398 acyl-activating enzyme (AAE) consensus motif; other site 1389489002399 putative AMP binding site [chemical binding]; other site 1389489002400 putative active site [active] 1389489002401 putative CoA binding site [chemical binding]; other site 1389489002402 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 1389489002403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1389489002404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1389489002405 active site 1389489002406 catalytic tetrad [active] 1389489002407 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1389489002408 active site 1389489002409 DNA polymerase IV; Validated; Region: PRK02406 1389489002410 DNA binding site [nucleotide binding] 1389489002411 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1389489002412 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1389489002413 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1389489002414 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1389489002415 Walker A/P-loop; other site 1389489002416 ATP binding site [chemical binding]; other site 1389489002417 Q-loop/lid; other site 1389489002418 ABC transporter signature motif; other site 1389489002419 Walker B; other site 1389489002420 D-loop; other site 1389489002421 H-loop/switch region; other site 1389489002422 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1389489002423 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1389489002424 Walker A/P-loop; other site 1389489002425 ATP binding site [chemical binding]; other site 1389489002426 Q-loop/lid; other site 1389489002427 ABC transporter signature motif; other site 1389489002428 Walker B; other site 1389489002429 D-loop; other site 1389489002430 H-loop/switch region; other site 1389489002431 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1389489002432 hypothetical protein; Provisional; Region: PRK06547 1389489002433 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1389489002434 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1389489002435 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1389489002436 catalytic residue [active] 1389489002437 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1389489002438 catalytic residues [active] 1389489002439 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1389489002440 active site 1389489002441 catalytic triad [active] 1389489002442 oxyanion hole [active] 1389489002443 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1389489002444 putative active site [active] 1389489002445 putative substrate binding site [chemical binding]; other site 1389489002446 dimer interface [polypeptide binding]; other site 1389489002447 catalytic site [active] 1389489002448 Lsr2; Region: Lsr2; pfam11774 1389489002449 HTH-like domain; Region: HTH_21; pfam13276 1389489002450 Transposase; Region: HTH_Tnp_1; cl17663 1389489002451 Integrase core domain; Region: rve; pfam00665 1389489002452 Integrase core domain; Region: rve_3; pfam13683 1389489002453 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1389489002454 alanine racemase; Reviewed; Region: alr; PRK00053 1389489002455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1389489002456 active site 1389489002457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1389489002458 dimer interface [polypeptide binding]; other site 1389489002459 substrate binding site [chemical binding]; other site 1389489002460 catalytic residues [active] 1389489002461 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489002462 catalytic residue [active] 1389489002463 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489002464 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1389489002465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489002466 ATP binding site [chemical binding]; other site 1389489002467 Mg2+ binding site [ion binding]; other site 1389489002468 G-X-G motif; other site 1389489002469 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1389489002470 anchoring element; other site 1389489002471 dimer interface [polypeptide binding]; other site 1389489002472 ATP binding site [chemical binding]; other site 1389489002473 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1389489002474 active site 1389489002475 metal binding site [ion binding]; metal-binding site 1389489002476 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1389489002477 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1389489002478 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1389489002479 CAP-like domain; other site 1389489002480 active site 1389489002481 primary dimer interface [polypeptide binding]; other site 1389489002482 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1389489002483 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1389489002484 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1389489002485 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1389489002486 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1389489002487 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1389489002488 trimer interface [polypeptide binding]; other site 1389489002489 active site 1389489002490 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1389489002491 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1389489002492 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1389489002493 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1389489002494 aconitate hydratase; Validated; Region: PRK09277 1389489002495 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1389489002496 substrate binding site [chemical binding]; other site 1389489002497 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1389489002498 ligand binding site [chemical binding]; other site 1389489002499 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1389489002500 substrate binding site [chemical binding]; other site 1389489002501 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1389489002502 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1389489002503 TPP-binding site; other site 1389489002504 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1389489002505 PYR/PP interface [polypeptide binding]; other site 1389489002506 dimer interface [polypeptide binding]; other site 1389489002507 TPP binding site [chemical binding]; other site 1389489002508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1389489002509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489002510 Walker A/P-loop; other site 1389489002511 ATP binding site [chemical binding]; other site 1389489002512 Q-loop/lid; other site 1389489002513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1389489002514 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1389489002515 substrate binding site [chemical binding]; other site 1389489002516 oxyanion hole (OAH) forming residues; other site 1389489002517 trimer interface [polypeptide binding]; other site 1389489002518 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1389489002519 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1389489002520 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1389489002521 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1389489002522 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1389489002523 dimer interface [polypeptide binding]; other site 1389489002524 active site 1389489002525 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1389489002526 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1389489002527 catalytic site [active] 1389489002528 putative active site [active] 1389489002529 putative substrate binding site [chemical binding]; other site 1389489002530 HRDC domain; Region: HRDC; pfam00570 1389489002531 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1389489002532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1389489002533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1389489002534 Fe-S metabolism associated domain; Region: SufE; cl00951 1389489002535 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1389489002536 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1389489002537 active site residue [active] 1389489002538 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1389489002539 active site residue [active] 1389489002540 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1389489002541 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1389489002542 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1389489002543 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1389489002544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489002545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489002546 homodimer interface [polypeptide binding]; other site 1389489002547 catalytic residue [active] 1389489002548 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489002549 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489002550 Integrase core domain; Region: rve; pfam00665 1389489002551 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1389489002552 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1389489002553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489002554 S-adenosylmethionine binding site [chemical binding]; other site 1389489002555 Integrase core domain; Region: rve; pfam00665 1389489002556 Integrase core domain; Region: rve_3; pfam13683 1389489002557 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1389489002558 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1389489002559 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1389489002560 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1389489002561 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1389489002562 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1389489002563 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1389489002564 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1389489002565 active site 1389489002566 dimer interface [polypeptide binding]; other site 1389489002567 motif 1; other site 1389489002568 motif 2; other site 1389489002569 motif 3; other site 1389489002570 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1389489002571 anticodon binding site; other site 1389489002572 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1389489002573 nucleotide binding site/active site [active] 1389489002574 HIT family signature motif; other site 1389489002575 catalytic residue [active] 1389489002576 pyridoxamine kinase; Validated; Region: PRK05756 1389489002577 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1389489002578 dimer interface [polypeptide binding]; other site 1389489002579 pyridoxal binding site [chemical binding]; other site 1389489002580 ATP binding site [chemical binding]; other site 1389489002581 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1389489002582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489002583 DNA-binding site [nucleotide binding]; DNA binding site 1389489002584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489002585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489002586 homodimer interface [polypeptide binding]; other site 1389489002587 catalytic residue [active] 1389489002588 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1389489002589 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1389489002590 active site 1389489002591 multimer interface [polypeptide binding]; other site 1389489002592 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1389489002593 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1389489002594 predicted active site [active] 1389489002595 catalytic triad [active] 1389489002596 hypothetical protein; Validated; Region: PRK00110 1389489002597 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1389489002598 active site 1389489002599 putative DNA-binding cleft [nucleotide binding]; other site 1389489002600 dimer interface [polypeptide binding]; other site 1389489002601 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1389489002602 RuvA N terminal domain; Region: RuvA_N; pfam01330 1389489002603 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1389489002604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489002605 Walker A motif; other site 1389489002606 ATP binding site [chemical binding]; other site 1389489002607 Walker B motif; other site 1389489002608 arginine finger; other site 1389489002609 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1389489002610 Preprotein translocase subunit; Region: YajC; pfam02699 1389489002611 protein-export membrane protein SecD; Region: secD; TIGR01129 1389489002612 Protein export membrane protein; Region: SecD_SecF; cl14618 1389489002613 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1389489002614 Protein export membrane protein; Region: SecD_SecF; pfam02355 1389489002615 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1389489002616 active site residue [active] 1389489002617 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1389489002618 HD domain; Region: HD_4; pfam13328 1389489002619 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1389489002620 synthetase active site [active] 1389489002621 NTP binding site [chemical binding]; other site 1389489002622 metal binding site [ion binding]; metal-binding site 1389489002623 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1389489002624 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1389489002625 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1389489002626 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1389489002627 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1389489002628 active site 1389489002629 recombination factor protein RarA; Reviewed; Region: PRK13342 1389489002630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489002631 Walker A motif; other site 1389489002632 ATP binding site [chemical binding]; other site 1389489002633 Walker B motif; other site 1389489002634 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1389489002635 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1389489002636 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1389489002637 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1389489002638 RNA binding surface [nucleotide binding]; other site 1389489002639 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1389489002640 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1389489002641 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1389489002642 motif 1; other site 1389489002643 active site 1389489002644 motif 2; other site 1389489002645 motif 3; other site 1389489002646 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1389489002647 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1389489002648 YceG-like family; Region: YceG; pfam02618 1389489002649 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1389489002650 dimerization interface [polypeptide binding]; other site 1389489002651 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1389489002652 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1389489002653 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1389489002654 shikimate binding site; other site 1389489002655 NAD(P) binding site [chemical binding]; other site 1389489002656 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1389489002657 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1389489002658 Tetramer interface [polypeptide binding]; other site 1389489002659 active site 1389489002660 FMN-binding site [chemical binding]; other site 1389489002661 shikimate kinase; Reviewed; Region: aroK; PRK00131 1389489002662 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1389489002663 ADP binding site [chemical binding]; other site 1389489002664 magnesium binding site [ion binding]; other site 1389489002665 putative shikimate binding site; other site 1389489002666 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1389489002667 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1389489002668 active site 1389489002669 dimer interface [polypeptide binding]; other site 1389489002670 metal binding site [ion binding]; metal-binding site 1389489002671 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1389489002672 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1389489002673 trimer interface [polypeptide binding]; other site 1389489002674 active site 1389489002675 dimer interface [polypeptide binding]; other site 1389489002676 elongation factor P; Validated; Region: PRK00529 1389489002677 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1389489002678 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1389489002679 RNA binding site [nucleotide binding]; other site 1389489002680 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1389489002681 RNA binding site [nucleotide binding]; other site 1389489002682 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1389489002683 putative RNA binding site [nucleotide binding]; other site 1389489002684 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1389489002685 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1389489002686 catalytic residues [active] 1389489002687 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1389489002688 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1389489002689 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1389489002690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489002691 active site 1389489002692 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1389489002693 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1389489002694 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1389489002695 dihydroorotase; Validated; Region: pyrC; PRK09357 1389489002696 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1389489002697 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1389489002698 active site 1389489002699 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1389489002700 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1389489002701 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1389489002702 catalytic site [active] 1389489002703 subunit interface [polypeptide binding]; other site 1389489002704 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1389489002705 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1389489002706 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1389489002707 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1389489002708 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1389489002709 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1389489002710 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1389489002711 IMP binding site; other site 1389489002712 dimer interface [polypeptide binding]; other site 1389489002713 interdomain contacts; other site 1389489002714 partial ornithine binding site; other site 1389489002715 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1389489002716 active site 1389489002717 dimer interface [polypeptide binding]; other site 1389489002718 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1389489002719 Guanylate kinase; Region: Guanylate_kin; pfam00625 1389489002720 catalytic site [active] 1389489002721 G-X2-G-X-G-K; other site 1389489002722 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1389489002723 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1389489002724 Flavoprotein; Region: Flavoprotein; pfam02441 1389489002725 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1389489002726 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1389489002727 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1389489002728 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1389489002729 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1389489002730 primosome assembly protein PriA; Provisional; Region: PRK14873 1389489002731 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1389489002732 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1389489002733 active site 1389489002734 catalytic triad [active] 1389489002735 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1389489002736 active site 1389489002737 Phage-related protein [Function unknown]; Region: COG5412 1389489002738 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1389489002739 active site 1389489002740 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489002741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489002742 active site 1389489002743 Int/Topo IB signature motif; other site 1389489002744 DNA binding site [nucleotide binding] 1389489002745 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1389489002746 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1389489002747 putative active site [active] 1389489002748 substrate binding site [chemical binding]; other site 1389489002749 putative cosubstrate binding site; other site 1389489002750 catalytic site [active] 1389489002751 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1389489002752 substrate binding site [chemical binding]; other site 1389489002753 NusB family; Region: NusB; pfam01029 1389489002754 putative RNA binding site [nucleotide binding]; other site 1389489002755 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1389489002756 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1389489002757 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1389489002758 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1389489002759 substrate binding site [chemical binding]; other site 1389489002760 hexamer interface [polypeptide binding]; other site 1389489002761 metal binding site [ion binding]; metal-binding site 1389489002762 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1389489002763 homodimer interface [polypeptide binding]; other site 1389489002764 putative metal binding site [ion binding]; other site 1389489002765 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1389489002766 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1389489002767 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1389489002768 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1389489002769 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1389489002770 substrate binding site [chemical binding]; other site 1389489002771 glutamase interaction surface [polypeptide binding]; other site 1389489002772 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1389489002773 anthranilate synthase component I; Provisional; Region: PRK13571 1389489002774 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1389489002775 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1389489002776 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1389489002777 active site 1389489002778 ribulose/triose binding site [chemical binding]; other site 1389489002779 phosphate binding site [ion binding]; other site 1389489002780 substrate (anthranilate) binding pocket [chemical binding]; other site 1389489002781 product (indole) binding pocket [chemical binding]; other site 1389489002782 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1389489002783 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1389489002784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489002785 catalytic residue [active] 1389489002786 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1389489002787 substrate binding site [chemical binding]; other site 1389489002788 active site 1389489002789 catalytic residues [active] 1389489002790 heterodimer interface [polypeptide binding]; other site 1389489002791 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489002792 Integrase core domain; Region: rve; pfam00665 1389489002793 Integrase core domain; Region: rve_3; pfam13683 1389489002794 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1389489002795 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1389489002796 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1389489002797 active site 1389489002798 dimer interface [polypeptide binding]; other site 1389489002799 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1389489002800 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1389489002801 active site 1389489002802 FMN binding site [chemical binding]; other site 1389489002803 substrate binding site [chemical binding]; other site 1389489002804 3Fe-4S cluster binding site [ion binding]; other site 1389489002805 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1389489002806 domain interface; other site 1389489002807 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1389489002808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1389489002809 pyruvate kinase; Provisional; Region: PRK06247 1389489002810 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1389489002811 domain interfaces; other site 1389489002812 active site 1389489002813 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1389489002814 EamA-like transporter family; Region: EamA; pfam00892 1389489002815 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1389489002816 active site 1389489002817 catalytic triad [active] 1389489002818 oxyanion hole [active] 1389489002819 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489002820 Integrase core domain; Region: rve; pfam00665 1389489002821 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1389489002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489002823 active site 1389489002824 phosphorylation site [posttranslational modification] 1389489002825 intermolecular recognition site; other site 1389489002826 dimerization interface [polypeptide binding]; other site 1389489002827 ANTAR domain; Region: ANTAR; pfam03861 1389489002828 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1389489002829 CoenzymeA binding site [chemical binding]; other site 1389489002830 subunit interaction site [polypeptide binding]; other site 1389489002831 PHB binding site; other site 1389489002832 DNA polymerase I; Provisional; Region: PRK05755 1389489002833 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1389489002834 active site 1389489002835 metal binding site 1 [ion binding]; metal-binding site 1389489002836 putative 5' ssDNA interaction site; other site 1389489002837 metal binding site 3; metal-binding site 1389489002838 metal binding site 2 [ion binding]; metal-binding site 1389489002839 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1389489002840 putative DNA binding site [nucleotide binding]; other site 1389489002841 putative metal binding site [ion binding]; other site 1389489002842 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1389489002843 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1389489002844 active site 1389489002845 DNA binding site [nucleotide binding] 1389489002846 catalytic site [active] 1389489002847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 1389489002848 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1389489002849 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1389489002850 RNA binding site [nucleotide binding]; other site 1389489002851 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1389489002852 RNA binding site [nucleotide binding]; other site 1389489002853 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1389489002854 RNA binding site [nucleotide binding]; other site 1389489002855 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1389489002856 RNA binding site [nucleotide binding]; other site 1389489002857 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1389489002858 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1389489002859 CoA-binding site [chemical binding]; other site 1389489002860 ATP-binding [chemical binding]; other site 1389489002861 excinuclease ABC subunit B; Provisional; Region: PRK05298 1389489002862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489002863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489002864 nucleotide binding region [chemical binding]; other site 1389489002865 ATP-binding site [chemical binding]; other site 1389489002866 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1389489002867 UvrB/uvrC motif; Region: UVR; pfam02151 1389489002868 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1389489002869 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1389489002870 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1389489002871 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1389489002872 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1389489002873 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1389489002874 GIY-YIG motif/motif A; other site 1389489002875 active site 1389489002876 catalytic site [active] 1389489002877 putative DNA binding site [nucleotide binding]; other site 1389489002878 metal binding site [ion binding]; metal-binding site 1389489002879 UvrB/uvrC motif; Region: UVR; pfam02151 1389489002880 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1389489002881 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1389489002882 shikimate kinase; Reviewed; Region: aroK; PRK00131 1389489002883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1389489002884 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1389489002885 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1389489002886 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1389489002887 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1389489002888 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1389489002889 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1389489002890 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1389489002891 Phosphoglycerate kinase; Region: PGK; pfam00162 1389489002892 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1389489002893 substrate binding site [chemical binding]; other site 1389489002894 hinge regions; other site 1389489002895 ADP binding site [chemical binding]; other site 1389489002896 catalytic site [active] 1389489002897 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1389489002898 triosephosphate isomerase; Provisional; Region: PRK14565 1389489002899 substrate binding site [chemical binding]; other site 1389489002900 dimer interface [polypeptide binding]; other site 1389489002901 catalytic triad [active] 1389489002902 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1389489002903 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1389489002904 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1389489002905 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1389489002906 putative active site [active] 1389489002907 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1389489002908 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1389489002909 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1389489002910 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1389489002911 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1389489002912 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1389489002913 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1389489002914 active site 1389489002915 dimer interface [polypeptide binding]; other site 1389489002916 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1389489002917 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1389489002918 putative active site [active] 1389489002919 transaldolase; Provisional; Region: PRK03903 1389489002920 catalytic residue [active] 1389489002921 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1389489002922 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1389489002923 TPP-binding site [chemical binding]; other site 1389489002924 dimer interface [polypeptide binding]; other site 1389489002925 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1389489002926 PYR/PP interface [polypeptide binding]; other site 1389489002927 dimer interface [polypeptide binding]; other site 1389489002928 TPP binding site [chemical binding]; other site 1389489002929 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1389489002930 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1389489002931 UbiA prenyltransferase family; Region: UbiA; pfam01040 1389489002932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1389489002933 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1389489002934 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1389489002935 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1389489002936 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1389489002937 FeS assembly protein SufB; Region: sufB; TIGR01980 1389489002938 FeS assembly protein SufD; Region: sufD; TIGR01981 1389489002939 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1389489002940 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1389489002941 [2Fe-2S] cluster binding site [ion binding]; other site 1389489002942 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1389489002943 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1389489002944 Walker A/P-loop; other site 1389489002945 ATP binding site [chemical binding]; other site 1389489002946 Q-loop/lid; other site 1389489002947 ABC transporter signature motif; other site 1389489002948 Walker B; other site 1389489002949 D-loop; other site 1389489002950 H-loop/switch region; other site 1389489002951 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1389489002952 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1389489002953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489002954 Walker A/P-loop; other site 1389489002955 ATP binding site [chemical binding]; other site 1389489002956 Q-loop/lid; other site 1389489002957 ABC transporter signature motif; other site 1389489002958 Walker B; other site 1389489002959 D-loop; other site 1389489002960 H-loop/switch region; other site 1389489002961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1389489002962 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1389489002963 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1389489002964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489002965 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1389489002966 NAD(P) binding site [chemical binding]; other site 1389489002967 active site 1389489002968 Integrase core domain; Region: rve; pfam00665 1389489002969 Integrase core domain; Region: rve_3; pfam13683 1389489002970 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1389489002971 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1389489002972 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1389489002973 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1389489002974 ligand binding site; other site 1389489002975 oligomer interface; other site 1389489002976 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1389489002977 dimer interface [polypeptide binding]; other site 1389489002978 N-terminal domain interface [polypeptide binding]; other site 1389489002979 sulfate 1 binding site; other site 1389489002980 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1389489002981 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1389489002982 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1389489002983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489002984 Walker A/P-loop; other site 1389489002985 ATP binding site [chemical binding]; other site 1389489002986 ABC transporter signature motif; other site 1389489002987 Walker B; other site 1389489002988 D-loop; other site 1389489002989 H-loop/switch region; other site 1389489002990 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1389489002991 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1389489002992 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1389489002993 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1389489002994 active site 1389489002995 catalytic site [active] 1389489002996 substrate binding site [chemical binding]; other site 1389489002997 trehalose synthase; Region: treS_nterm; TIGR02456 1389489002998 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1389489002999 active site 1389489003000 catalytic site [active] 1389489003001 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1389489003002 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1389489003003 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1389489003004 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1389489003005 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1389489003006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1389489003007 catalytic core [active] 1389489003008 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1389489003009 NAD-dependent deacetylase; Provisional; Region: PRK05333 1389489003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1389489003011 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1389489003012 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1389489003013 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1389489003014 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1389489003015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489003016 Walker A/P-loop; other site 1389489003017 ATP binding site [chemical binding]; other site 1389489003018 Q-loop/lid; other site 1389489003019 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1389489003020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489003021 ABC transporter signature motif; other site 1389489003022 Walker B; other site 1389489003023 D-loop; other site 1389489003024 H-loop/switch region; other site 1389489003025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489003026 ABC transporter signature motif; other site 1389489003027 Walker B; other site 1389489003028 D-loop; other site 1389489003029 H-loop/switch region; other site 1389489003030 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1389489003031 active site 1389489003032 catalytic triad [active] 1389489003033 oxyanion hole [active] 1389489003034 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1389489003035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489003036 ATP binding site [chemical binding]; other site 1389489003037 putative Mg++ binding site [ion binding]; other site 1389489003038 glutamate dehydrogenase; Provisional; Region: PRK09414 1389489003039 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1389489003040 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1389489003041 NAD(P) binding site [chemical binding]; other site 1389489003042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1389489003043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489003044 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1389489003045 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1389489003046 CCC1-related family of proteins; Region: CCC1_like; cl00278 1389489003047 AMP nucleosidase; Provisional; Region: PRK07115 1389489003048 hypothetical protein; Provisional; Region: PRK06541 1389489003049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1389489003050 inhibitor-cofactor binding pocket; inhibition site 1389489003051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489003052 catalytic residue [active] 1389489003053 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1389489003054 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1389489003055 putative DNA binding site [nucleotide binding]; other site 1389489003056 putative Zn2+ binding site [ion binding]; other site 1389489003057 AsnC family; Region: AsnC_trans_reg; pfam01037 1389489003058 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1389489003059 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1389489003060 tetrameric interface [polypeptide binding]; other site 1389489003061 NAD binding site [chemical binding]; other site 1389489003062 catalytic residues [active] 1389489003063 substrate binding site [chemical binding]; other site 1389489003064 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489003065 NAD(P) binding site [chemical binding]; other site 1389489003066 catalytic residues [active] 1389489003067 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1389489003068 phosphopeptide binding site; other site 1389489003069 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1389489003070 active site 1389489003071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1389489003072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1389489003073 active site 1389489003074 ATP binding site [chemical binding]; other site 1389489003075 substrate binding site [chemical binding]; other site 1389489003076 activation loop (A-loop); other site 1389489003077 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1389489003078 Interdomain contacts; other site 1389489003079 Cytokine receptor motif; other site 1389489003080 MoxR-like ATPases [General function prediction only]; Region: COG0714 1389489003081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489003082 Walker A motif; other site 1389489003083 ATP binding site [chemical binding]; other site 1389489003084 Walker B motif; other site 1389489003085 arginine finger; other site 1389489003086 Protein of unknown function DUF58; Region: DUF58; pfam01882 1389489003087 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1389489003088 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489003089 transposase/IS protein; Provisional; Region: PRK09183 1389489003090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489003091 Walker A motif; other site 1389489003092 ATP binding site [chemical binding]; other site 1389489003093 Walker B motif; other site 1389489003094 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1389489003095 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1389489003096 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1389489003097 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1389489003098 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1389489003099 short chain dehydrogenase; Provisional; Region: PRK07806 1389489003100 NAD(P) binding site [chemical binding]; other site 1389489003101 active site 1389489003102 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1389489003103 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1389489003104 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1389489003105 Integrase core domain; Region: rve; pfam00665 1389489003106 Integrase core domain; Region: rve_3; cl15866 1389489003107 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1389489003108 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1389489003109 putative dimer interface [polypeptide binding]; other site 1389489003110 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1389489003111 PIN domain; Region: PIN_3; cl17397 1389489003112 Putative amidase domain; Region: Amidase_6; pfam12671 1389489003113 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1389489003114 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1389489003115 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1389489003116 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1389489003117 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1389489003118 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1389489003119 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1389489003120 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1389489003121 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489003122 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1389489003123 PIN domain; Region: PIN_3; pfam13470 1389489003124 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1389489003125 DNA binding residues [nucleotide binding] 1389489003126 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489003127 Putative amidase domain; Region: Amidase_6; pfam12671 1389489003128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1389489003129 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1389489003130 dimer interface [polypeptide binding]; other site 1389489003131 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1389489003132 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1389489003133 dimer interface [polypeptide binding]; other site 1389489003134 catalytic triad [active] 1389489003135 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1389489003136 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1389489003137 dimer interface [polypeptide binding]; other site 1389489003138 TPP-binding site [chemical binding]; other site 1389489003139 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1389489003140 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1389489003141 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1389489003142 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1389489003143 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1389489003144 dimer interface [polypeptide binding]; other site 1389489003145 active site 1389489003146 CoA binding pocket [chemical binding]; other site 1389489003147 acyl carrier protein; Provisional; Region: acpP; PRK00982 1389489003148 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1389489003149 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1389489003150 dimer interface [polypeptide binding]; other site 1389489003151 active site 1389489003152 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1389489003153 Predicted transcriptional regulators [Transcription]; Region: COG1695 1389489003154 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1389489003155 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1389489003156 NUDIX domain; Region: NUDIX; pfam00293 1389489003157 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1389489003158 nudix motif; other site 1389489003159 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1389489003160 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1389489003161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489003162 putative ADP-binding pocket [chemical binding]; other site 1389489003163 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 1389489003164 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1389489003165 active site 1389489003166 catalytic residues [active] 1389489003167 metal binding site [ion binding]; metal-binding site 1389489003168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489003169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489003170 ATP binding site [chemical binding]; other site 1389489003171 Mg2+ binding site [ion binding]; other site 1389489003172 G-X-G motif; other site 1389489003173 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1389489003174 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1389489003175 NAD binding site [chemical binding]; other site 1389489003176 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489003177 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489003178 Integrase core domain; Region: rve; pfam00665 1389489003179 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1389489003180 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1389489003181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489003182 Walker A/P-loop; other site 1389489003183 ATP binding site [chemical binding]; other site 1389489003184 Q-loop/lid; other site 1389489003185 ABC transporter signature motif; other site 1389489003186 Walker B; other site 1389489003187 D-loop; other site 1389489003188 H-loop/switch region; other site 1389489003189 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1389489003190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489003191 Walker A/P-loop; other site 1389489003192 ATP binding site [chemical binding]; other site 1389489003193 Q-loop/lid; other site 1389489003194 ABC transporter signature motif; other site 1389489003195 Walker B; other site 1389489003196 D-loop; other site 1389489003197 H-loop/switch region; other site 1389489003198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489003199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489003200 Walker A/P-loop; other site 1389489003201 ATP binding site [chemical binding]; other site 1389489003202 Q-loop/lid; other site 1389489003203 ABC transporter signature motif; other site 1389489003204 Walker B; other site 1389489003205 D-loop; other site 1389489003206 H-loop/switch region; other site 1389489003207 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489003208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1389489003209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489003210 dimer interface [polypeptide binding]; other site 1389489003211 conserved gate region; other site 1389489003212 ABC-ATPase subunit interface; other site 1389489003213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1389489003214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489003215 dimer interface [polypeptide binding]; other site 1389489003216 conserved gate region; other site 1389489003217 ABC-ATPase subunit interface; other site 1389489003218 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1389489003219 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1389489003220 DNA primase; Validated; Region: dnaG; PRK05667 1389489003221 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1389489003222 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1389489003223 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1389489003224 active site 1389489003225 metal binding site [ion binding]; metal-binding site 1389489003226 interdomain interaction site; other site 1389489003227 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1389489003228 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1389489003229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1389489003230 Zn2+ binding site [ion binding]; other site 1389489003231 Mg2+ binding site [ion binding]; other site 1389489003232 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1389489003233 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1389489003234 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1389489003235 FMN binding site [chemical binding]; other site 1389489003236 active site 1389489003237 catalytic residues [active] 1389489003238 substrate binding site [chemical binding]; other site 1389489003239 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1389489003240 putative deacylase active site [active] 1389489003241 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1389489003242 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1389489003243 catalytic residues [active] 1389489003244 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1389489003245 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1389489003246 catalytic residue [active] 1389489003247 putative FPP diphosphate binding site; other site 1389489003248 putative FPP binding hydrophobic cleft; other site 1389489003249 dimer interface [polypeptide binding]; other site 1389489003250 putative IPP diphosphate binding site; other site 1389489003251 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1389489003252 Recombination protein O N terminal; Region: RecO_N; pfam11967 1389489003253 Recombination protein O C terminal; Region: RecO_C; pfam02565 1389489003254 Predicted membrane protein [Function unknown]; Region: COG2860 1389489003255 UPF0126 domain; Region: UPF0126; pfam03458 1389489003256 2-isopropylmalate synthase; Validated; Region: PRK03739 1389489003257 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1389489003258 active site 1389489003259 catalytic residues [active] 1389489003260 metal binding site [ion binding]; metal-binding site 1389489003261 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1389489003262 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1389489003263 Predicted esterase [General function prediction only]; Region: COG0627 1389489003264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1389489003265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1389489003266 Walker A/P-loop; other site 1389489003267 ATP binding site [chemical binding]; other site 1389489003268 Q-loop/lid; other site 1389489003269 ABC transporter signature motif; other site 1389489003270 Walker B; other site 1389489003271 D-loop; other site 1389489003272 H-loop/switch region; other site 1389489003273 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489003274 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489003275 Integrase core domain; Region: rve; pfam00665 1389489003276 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489003277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489003278 DNA binding residues [nucleotide binding] 1389489003279 dimerization interface [polypeptide binding]; other site 1389489003280 Histidine kinase; Region: HisKA_3; pfam07730 1389489003281 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1389489003282 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1389489003283 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1389489003284 Q-X-W motif; other site 1389489003285 putative sugar binding sites [chemical binding]; other site 1389489003286 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1389489003287 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1389489003288 putative sugar binding sites [chemical binding]; other site 1389489003289 Q-X-W motif; other site 1389489003290 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1389489003291 GTPase Era; Reviewed; Region: era; PRK00089 1389489003292 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1389489003293 G1 box; other site 1389489003294 GTP/Mg2+ binding site [chemical binding]; other site 1389489003295 Switch I region; other site 1389489003296 G2 box; other site 1389489003297 Switch II region; other site 1389489003298 G3 box; other site 1389489003299 G4 box; other site 1389489003300 G5 box; other site 1389489003301 KH domain; Region: KH_2; pfam07650 1389489003302 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1389489003303 Domain of unknown function DUF21; Region: DUF21; pfam01595 1389489003304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1389489003305 Transporter associated domain; Region: CorC_HlyC; smart01091 1389489003306 metal-binding heat shock protein; Provisional; Region: PRK00016 1389489003307 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1389489003308 PhoH-like protein; Region: PhoH; pfam02562 1389489003309 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1389489003310 nucleotide binding site/active site [active] 1389489003311 HIT family signature motif; other site 1389489003312 catalytic residue [active] 1389489003313 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1389489003314 chaperone protein DnaJ; Provisional; Region: PRK14278 1389489003315 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1389489003316 HSP70 interaction site [polypeptide binding]; other site 1389489003317 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1389489003318 Zn binding sites [ion binding]; other site 1389489003319 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1389489003320 dimer interface [polypeptide binding]; other site 1389489003321 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1389489003322 Tic20-like protein; Region: Tic20; pfam09685 1389489003323 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1389489003324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1389489003325 FeS/SAM binding site; other site 1389489003326 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1389489003327 GTP-binding protein LepA; Provisional; Region: PRK05433 1389489003328 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1389489003329 G1 box; other site 1389489003330 putative GEF interaction site [polypeptide binding]; other site 1389489003331 GTP/Mg2+ binding site [chemical binding]; other site 1389489003332 Switch I region; other site 1389489003333 G2 box; other site 1389489003334 G3 box; other site 1389489003335 Switch II region; other site 1389489003336 G4 box; other site 1389489003337 G5 box; other site 1389489003338 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1389489003339 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1389489003340 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1389489003341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1389489003342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489003343 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1389489003344 NAD(P) binding site [chemical binding]; other site 1389489003345 active site 1389489003346 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1389489003347 hypothetical protein; Reviewed; Region: PRK07914 1389489003348 Competence protein; Region: Competence; pfam03772 1389489003349 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1389489003350 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1389489003351 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1389489003352 HIGH motif; other site 1389489003353 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1389489003354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1389489003355 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1389489003356 active site 1389489003357 KMSKS motif; other site 1389489003358 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1389489003359 tRNA binding surface [nucleotide binding]; other site 1389489003360 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1389489003361 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1389489003362 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1389489003363 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1389489003364 substrate-cofactor binding pocket; other site 1389489003365 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1389489003366 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1389489003367 Walker A/P-loop; other site 1389489003368 ATP binding site [chemical binding]; other site 1389489003369 Q-loop/lid; other site 1389489003370 ABC transporter signature motif; other site 1389489003371 Walker B; other site 1389489003372 D-loop; other site 1389489003373 H-loop/switch region; other site 1389489003374 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1389489003375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1389489003376 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1389489003377 ABC transporter signature motif; other site 1389489003378 Walker B; other site 1389489003379 D-loop; other site 1389489003380 H-loop/switch region; other site 1389489003381 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1389489003382 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1389489003383 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1389489003384 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1389489003385 Penicillinase repressor; Region: Pencillinase_R; cl17580 1389489003386 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1389489003387 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1389489003388 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489003389 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1389489003390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1389489003391 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1389489003392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489003393 Walker A/P-loop; other site 1389489003394 ATP binding site [chemical binding]; other site 1389489003395 Q-loop/lid; other site 1389489003396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489003397 D-loop; other site 1389489003398 H-loop/switch region; other site 1389489003399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1389489003400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489003401 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1389489003402 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1389489003403 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1389489003404 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1389489003405 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1389489003406 dimer interface [polypeptide binding]; other site 1389489003407 motif 1; other site 1389489003408 active site 1389489003409 motif 2; other site 1389489003410 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1389489003411 putative deacylase active site [active] 1389489003412 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1389489003413 active site 1389489003414 motif 3; other site 1389489003415 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1389489003416 anticodon binding site; other site 1389489003417 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1389489003418 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1389489003419 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1389489003420 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1389489003421 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1389489003422 active site 1389489003423 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1389489003424 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1389489003425 putative substrate binding region [chemical binding]; other site 1389489003426 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1389489003427 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1389489003428 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1389489003429 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1389489003430 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1389489003431 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1389489003432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1389489003433 inhibitor-cofactor binding pocket; inhibition site 1389489003434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489003435 catalytic residue [active] 1389489003436 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1389489003437 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1389489003438 putative acyl-acceptor binding pocket; other site 1389489003439 OsmC-like protein; Region: OsmC; cl00767 1389489003440 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1389489003441 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1389489003442 inhibitor-cofactor binding pocket; inhibition site 1389489003443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489003444 catalytic residue [active] 1389489003445 L-asparaginase II; Region: Asparaginase_II; pfam06089 1389489003446 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1389489003447 transposase/IS protein; Provisional; Region: PRK09183 1389489003448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489003449 Walker A motif; other site 1389489003450 ATP binding site [chemical binding]; other site 1389489003451 Walker B motif; other site 1389489003452 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489003453 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1389489003454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489003455 ATP binding site [chemical binding]; other site 1389489003456 putative Mg++ binding site [ion binding]; other site 1389489003457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489003458 nucleotide binding region [chemical binding]; other site 1389489003459 ATP-binding site [chemical binding]; other site 1389489003460 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1389489003461 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1389489003462 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1389489003463 Predicted transcriptional regulator [Transcription]; Region: COG2378 1389489003464 WYL domain; Region: WYL; pfam13280 1389489003465 Predicted transcriptional regulator [Transcription]; Region: COG2378 1389489003466 WYL domain; Region: WYL; pfam13280 1389489003467 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1389489003468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489003469 S-adenosylmethionine binding site [chemical binding]; other site 1389489003470 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1389489003471 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1389489003472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489003473 motif II; other site 1389489003474 PAC2 family; Region: PAC2; pfam09754 1389489003475 Bacitracin resistance protein BacA; Region: BacA; cl00858 1389489003476 hypothetical protein; Provisional; Region: PRK07906 1389489003477 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1389489003478 putative metal binding site [ion binding]; other site 1389489003479 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 1389489003480 diiron binding motif [ion binding]; other site 1389489003481 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1389489003482 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1389489003483 Rhodanese-like domain; Region: Rhodanese; pfam00581 1389489003484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1389489003485 active site residue [active] 1389489003486 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1389489003487 putative homotetramer interface [polypeptide binding]; other site 1389489003488 putative homodimer interface [polypeptide binding]; other site 1389489003489 putative allosteric switch controlling residues; other site 1389489003490 putative metal binding site [ion binding]; other site 1389489003491 putative homodimer-homodimer interface [polypeptide binding]; other site 1389489003492 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1389489003493 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1389489003494 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1389489003495 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1389489003496 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1389489003497 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1389489003498 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1389489003499 active site 1389489003500 (T/H)XGH motif; other site 1389489003501 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489003502 NAD(P) binding site [chemical binding]; other site 1389489003503 catalytic residues [active] 1389489003504 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1389489003505 homotetrameric interface [polypeptide binding]; other site 1389489003506 putative phosphate binding site [ion binding]; other site 1389489003507 putative allosteric binding site; other site 1389489003508 nucleotide binding site [chemical binding]; other site 1389489003509 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1389489003510 GTP1/OBG; Region: GTP1_OBG; pfam01018 1389489003511 Obg GTPase; Region: Obg; cd01898 1389489003512 G1 box; other site 1389489003513 GTP/Mg2+ binding site [chemical binding]; other site 1389489003514 Switch I region; other site 1389489003515 G2 box; other site 1389489003516 G3 box; other site 1389489003517 Switch II region; other site 1389489003518 G4 box; other site 1389489003519 G5 box; other site 1389489003520 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1389489003521 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1389489003522 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1389489003523 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 1389489003524 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1389489003525 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1389489003526 homodimer interface [polypeptide binding]; other site 1389489003527 oligonucleotide binding site [chemical binding]; other site 1389489003528 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1389489003529 putative active site [active] 1389489003530 redox center [active] 1389489003531 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1389489003532 active site 1389489003533 multimer interface [polypeptide binding]; other site 1389489003534 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1389489003535 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1389489003536 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1389489003537 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1389489003538 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1389489003539 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1389489003540 HIGH motif; other site 1389489003541 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1389489003542 active site 1389489003543 KMSKS motif; other site 1389489003544 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1389489003545 tRNA binding surface [nucleotide binding]; other site 1389489003546 anticodon binding site; other site 1389489003547 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1389489003548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489003549 metabolite-proton symporter; Region: 2A0106; TIGR00883 1389489003550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489003551 putative substrate translocation pore; other site 1389489003552 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1389489003553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1389489003554 active site 1389489003555 HIGH motif; other site 1389489003556 nucleotide binding site [chemical binding]; other site 1389489003557 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1389489003558 active site 1389489003559 KMSKS motif; other site 1389489003560 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1389489003561 tRNA binding surface [nucleotide binding]; other site 1389489003562 anticodon binding site; other site 1389489003563 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1389489003564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1389489003565 Coenzyme A binding pocket [chemical binding]; other site 1389489003566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1389489003567 dimerization interface [polypeptide binding]; other site 1389489003568 putative DNA binding site [nucleotide binding]; other site 1389489003569 putative Zn2+ binding site [ion binding]; other site 1389489003570 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1389489003571 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1389489003572 active site 1389489003573 Zn binding site [ion binding]; other site 1389489003574 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1389489003575 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1389489003576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489003577 Walker A motif; other site 1389489003578 ATP binding site [chemical binding]; other site 1389489003579 Walker B motif; other site 1389489003580 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1389489003581 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1389489003582 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1389489003583 oligomer interface [polypeptide binding]; other site 1389489003584 active site residues [active] 1389489003585 Clp protease; Region: CLP_protease; pfam00574 1389489003586 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1389489003587 oligomer interface [polypeptide binding]; other site 1389489003588 active site residues [active] 1389489003589 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1389489003590 trigger factor; Provisional; Region: tig; PRK01490 1389489003591 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1389489003592 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1389489003593 proline/glycine betaine transporter; Provisional; Region: PRK10642 1389489003594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489003595 putative substrate translocation pore; other site 1389489003596 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1389489003597 Integrase core domain; Region: rve; pfam00665 1389489003598 Integrase core domain; Region: rve_3; pfam13683 1389489003599 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1389489003600 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1389489003601 dimerization interface [polypeptide binding]; other site 1389489003602 DPS ferroxidase diiron center [ion binding]; other site 1389489003603 ion pore; other site 1389489003604 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1389489003605 putative DNA binding site [nucleotide binding]; other site 1389489003606 catalytic residue [active] 1389489003607 putative H2TH interface [polypeptide binding]; other site 1389489003608 putative catalytic residues [active] 1389489003609 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1389489003610 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1389489003611 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1389489003612 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1389489003613 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1389489003614 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1389489003615 Zn binding site [ion binding]; other site 1389489003616 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1389489003617 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1389489003618 Walker A/P-loop; other site 1389489003619 ATP binding site [chemical binding]; other site 1389489003620 Q-loop/lid; other site 1389489003621 ABC transporter signature motif; other site 1389489003622 Walker B; other site 1389489003623 D-loop; other site 1389489003624 H-loop/switch region; other site 1389489003625 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1389489003626 Histidine kinase; Region: HisKA_3; pfam07730 1389489003627 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1389489003628 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489003629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489003630 active site 1389489003631 phosphorylation site [posttranslational modification] 1389489003632 intermolecular recognition site; other site 1389489003633 dimerization interface [polypeptide binding]; other site 1389489003634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489003635 DNA binding residues [nucleotide binding] 1389489003636 dimerization interface [polypeptide binding]; other site 1389489003637 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1389489003638 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1389489003639 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1389489003640 apolar tunnel; other site 1389489003641 heme binding site [chemical binding]; other site 1389489003642 dimerization interface [polypeptide binding]; other site 1389489003643 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1389489003644 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1389489003645 active site 1389489003646 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1389489003647 catalytic triad [active] 1389489003648 dimer interface [polypeptide binding]; other site 1389489003649 Putative zinc-finger; Region: zf-HC2; pfam13490 1389489003650 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1389489003651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1389489003652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1389489003653 DNA binding residues [nucleotide binding] 1389489003654 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1389489003655 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1389489003656 iron-sulfur cluster [ion binding]; other site 1389489003657 [2Fe-2S] cluster binding site [ion binding]; other site 1389489003658 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1389489003659 active site 1389489003660 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1389489003661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489003662 Walker A/P-loop; other site 1389489003663 ATP binding site [chemical binding]; other site 1389489003664 Q-loop/lid; other site 1389489003665 ABC transporter signature motif; other site 1389489003666 Walker B; other site 1389489003667 D-loop; other site 1389489003668 H-loop/switch region; other site 1389489003669 ABC transporter; Region: ABC_tran_2; pfam12848 1389489003670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1389489003671 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1389489003672 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1389489003673 ssDNA binding site [nucleotide binding]; other site 1389489003674 dimer interface [polypeptide binding]; other site 1389489003675 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1389489003676 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1389489003677 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1389489003678 active site 1389489003679 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1389489003680 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1389489003681 homodimer interface [polypeptide binding]; other site 1389489003682 NAD binding pocket [chemical binding]; other site 1389489003683 ATP binding pocket [chemical binding]; other site 1389489003684 Mg binding site [ion binding]; other site 1389489003685 active-site loop [active] 1389489003686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1389489003687 putative Zn2+ binding site [ion binding]; other site 1389489003688 putative DNA binding site [nucleotide binding]; other site 1389489003689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1389489003690 dimerization interface [polypeptide binding]; other site 1389489003691 H+ Antiporter protein; Region: 2A0121; TIGR00900 1389489003692 RES domain; Region: RES; pfam08808 1389489003693 Integrase core domain; Region: rve; pfam00665 1389489003694 Integrase core domain; Region: rve_3; pfam13683 1389489003695 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1389489003696 conserved cys residue [active] 1389489003697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1389489003698 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1389489003699 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1389489003700 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1389489003701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1389489003702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1389489003703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1389489003704 DNA binding residues [nucleotide binding] 1389489003705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489003706 putative substrate translocation pore; other site 1389489003707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1389489003708 PAC2 family; Region: PAC2; pfam09754 1389489003709 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1389489003710 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1389489003711 interface (dimer of trimers) [polypeptide binding]; other site 1389489003712 Substrate-binding/catalytic site; other site 1389489003713 Zn-binding sites [ion binding]; other site 1389489003714 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1389489003715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1389489003716 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1389489003717 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1389489003718 E3 interaction surface; other site 1389489003719 lipoyl attachment site [posttranslational modification]; other site 1389489003720 e3 binding domain; Region: E3_binding; pfam02817 1389489003721 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1389489003722 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1389489003723 lipoate-protein ligase B; Provisional; Region: PRK14345 1389489003724 lipoyl synthase; Provisional; Region: PRK05481 1389489003725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1389489003726 FeS/SAM binding site; other site 1389489003727 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1389489003728 RDD family; Region: RDD; pfam06271 1389489003729 glutamine synthetase, type I; Region: GlnA; TIGR00653 1389489003730 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1389489003731 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1389489003732 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1389489003733 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1389489003734 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1389489003735 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1389489003736 metal binding triad; other site 1389489003737 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1389489003738 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1389489003739 metal binding triad; other site 1389489003740 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1389489003741 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1389489003742 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1389489003743 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1389489003744 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1389489003745 oligomerization interface [polypeptide binding]; other site 1389489003746 active site 1389489003747 metal binding site [ion binding]; metal-binding site 1389489003748 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1389489003749 active site 1389489003750 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489003751 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1389489003752 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1389489003753 Putative zinc ribbon domain; Region: DUF164; pfam02591 1389489003754 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1389489003755 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1389489003756 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1389489003757 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1389489003758 dimerization interface [polypeptide binding]; other site 1389489003759 active site 1389489003760 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1389489003761 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1389489003762 folate binding site [chemical binding]; other site 1389489003763 NADP+ binding site [chemical binding]; other site 1389489003764 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1389489003765 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1389489003766 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489003767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489003768 homodimer interface [polypeptide binding]; other site 1389489003769 catalytic residue [active] 1389489003770 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1389489003771 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1389489003772 dimerization domain swap beta strand [polypeptide binding]; other site 1389489003773 regulatory protein interface [polypeptide binding]; other site 1389489003774 active site 1389489003775 regulatory phosphorylation site [posttranslational modification]; other site 1389489003776 DAK2 domain; Region: Dak2; cl03685 1389489003777 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1389489003778 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1389489003779 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1389489003780 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1389489003781 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1389489003782 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1389489003783 Subunit I/III interface [polypeptide binding]; other site 1389489003784 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1389489003785 Cytochrome c; Region: Cytochrom_C; pfam00034 1389489003786 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1389489003787 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1389489003788 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1389489003789 iron-sulfur cluster [ion binding]; other site 1389489003790 [2Fe-2S] cluster binding site [ion binding]; other site 1389489003791 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1389489003792 heme bH binding site [chemical binding]; other site 1389489003793 Qi binding site; other site 1389489003794 intrachain domain interface; other site 1389489003795 heme bL binding site [chemical binding]; other site 1389489003796 interchain domain interface [polypeptide binding]; other site 1389489003797 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1389489003798 Qo binding site; other site 1389489003799 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1389489003800 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1389489003801 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1389489003802 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1389489003803 D-pathway; other site 1389489003804 Putative ubiquinol binding site [chemical binding]; other site 1389489003805 Low-spin heme (heme b) binding site [chemical binding]; other site 1389489003806 Putative water exit pathway; other site 1389489003807 Binuclear center (heme o3/CuB) [ion binding]; other site 1389489003808 K-pathway; other site 1389489003809 Putative proton exit pathway; other site 1389489003810 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1389489003811 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1389489003812 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1389489003813 hypothetical protein; Provisional; Region: PRK07907 1389489003814 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1389489003815 active site 1389489003816 metal binding site [ion binding]; metal-binding site 1389489003817 dimer interface [polypeptide binding]; other site 1389489003818 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1389489003819 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1389489003820 RNA/DNA hybrid binding site [nucleotide binding]; other site 1389489003821 active site 1389489003822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1389489003823 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1389489003824 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1389489003825 quinone interaction residues [chemical binding]; other site 1389489003826 active site 1389489003827 catalytic residues [active] 1389489003828 FMN binding site [chemical binding]; other site 1389489003829 substrate binding site [chemical binding]; other site 1389489003830 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1389489003831 ATP cone domain; Region: ATP-cone; pfam03477 1389489003832 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1389489003833 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1389489003834 NAD binding site [chemical binding]; other site 1389489003835 dimerization interface [polypeptide binding]; other site 1389489003836 product binding site; other site 1389489003837 substrate binding site [chemical binding]; other site 1389489003838 zinc binding site [ion binding]; other site 1389489003839 catalytic residues [active] 1389489003840 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1389489003841 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1389489003842 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1389489003843 active site 1389489003844 PHP Thumb interface [polypeptide binding]; other site 1389489003845 metal binding site [ion binding]; metal-binding site 1389489003846 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1389489003847 generic binding surface II; other site 1389489003848 generic binding surface I; other site 1389489003849 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1389489003850 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1389489003851 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1389489003852 active site 1389489003853 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1389489003854 DivIVA protein; Region: DivIVA; pfam05103 1389489003855 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1389489003856 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489003857 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1389489003858 catalytic residue [active] 1389489003859 cell division protein FtsZ; Validated; Region: PRK09330 1389489003860 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1389489003861 nucleotide binding site [chemical binding]; other site 1389489003862 SulA interaction site; other site 1389489003863 cell division protein FtsQ; Provisional; Region: PRK05529 1389489003864 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1389489003865 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1389489003866 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1389489003867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1389489003868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1389489003869 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1389489003870 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1389489003871 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1389489003872 homodimer interface [polypeptide binding]; other site 1389489003873 active site 1389489003874 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1389489003875 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1389489003876 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1389489003877 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1389489003878 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1389489003879 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1389489003880 Mg++ binding site [ion binding]; other site 1389489003881 putative catalytic motif [active] 1389489003882 putative substrate binding site [chemical binding]; other site 1389489003883 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1389489003884 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1389489003885 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1389489003886 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1389489003887 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1389489003888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1389489003889 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1389489003890 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1389489003891 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1389489003892 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1389489003893 MraW methylase family; Region: Methyltransf_5; cl17771 1389489003894 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1389489003895 cell division protein MraZ; Reviewed; Region: PRK00326 1389489003896 MraZ protein; Region: MraZ; pfam02381 1389489003897 MraZ protein; Region: MraZ; pfam02381 1389489003898 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1389489003899 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1389489003900 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1389489003901 substrate binding pocket [chemical binding]; other site 1389489003902 chain length determination region; other site 1389489003903 substrate-Mg2+ binding site; other site 1389489003904 catalytic residues [active] 1389489003905 aspartate-rich region 1; other site 1389489003906 active site lid residues [active] 1389489003907 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1389489003908 aspartate-rich region 2; other site 1389489003909 Helix-turn-helix domain; Region: HTH_17; cl17695 1389489003910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1389489003911 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1389489003912 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1389489003913 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1389489003914 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1389489003915 active site 1389489003916 ATP binding site [chemical binding]; other site 1389489003917 substrate binding site [chemical binding]; other site 1389489003918 activation loop (A-loop); other site 1389489003919 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489003920 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489003921 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489003922 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1389489003923 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1389489003924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1389489003925 putative acyl-acceptor binding pocket; other site 1389489003926 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1389489003927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1389489003928 nucleotide binding site [chemical binding]; other site 1389489003929 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1389489003930 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1389489003931 acyl-activating enzyme (AAE) consensus motif; other site 1389489003932 putative AMP binding site [chemical binding]; other site 1389489003933 putative active site [active] 1389489003934 putative CoA binding site [chemical binding]; other site 1389489003935 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1389489003936 active site 1389489003937 catalytic residues [active] 1389489003938 metal binding site [ion binding]; metal-binding site 1389489003939 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1389489003940 pyruvate carboxylase; Reviewed; Region: PRK12999 1389489003941 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1389489003942 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1389489003943 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1389489003944 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1389489003945 active site 1389489003946 catalytic residues [active] 1389489003947 metal binding site [ion binding]; metal-binding site 1389489003948 homodimer binding site [polypeptide binding]; other site 1389489003949 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1389489003950 carboxyltransferase (CT) interaction site; other site 1389489003951 biotinylation site [posttranslational modification]; other site 1389489003952 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1389489003953 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1389489003954 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1389489003955 Magnesium ion binding site [ion binding]; other site 1389489003956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489003957 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1389489003958 Int/Topo IB signature motif; other site 1389489003959 DNA binding site [nucleotide binding] 1389489003960 active site 1389489003961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489003962 non-specific DNA binding site [nucleotide binding]; other site 1389489003963 salt bridge; other site 1389489003964 sequence-specific DNA binding site [nucleotide binding]; other site 1389489003965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1389489003966 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1389489003967 Protein of unknown function (DUF739); Region: DUF739; pfam05339 1389489003968 BRO family, N-terminal domain; Region: Bro-N; smart01040 1389489003969 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1389489003970 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1389489003971 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1389489003972 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1389489003973 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1389489003974 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1389489003975 Phage capsid family; Region: Phage_capsid; pfam05065 1389489003976 Phage capsid family; Region: Phage_capsid; pfam05065 1389489003977 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1389489003978 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1389489003979 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489003980 active site 1389489003981 Ethylene-responsive protein kinase Le-CTR1; Region: EDR1; pfam14381 1389489003982 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1389489003983 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1389489003984 cofactor binding site; other site 1389489003985 DNA binding site [nucleotide binding] 1389489003986 substrate interaction site [chemical binding]; other site 1389489003987 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1389489003988 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1389489003989 DNA binding residues [nucleotide binding] 1389489003990 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1389489003991 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1389489003992 DNA binding residues [nucleotide binding] 1389489003993 dimer interface [polypeptide binding]; other site 1389489003994 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1389489003995 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1389489003996 phosphopeptide binding site; other site 1389489003997 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1389489003998 HEAT repeats; Region: HEAT_2; pfam13646 1389489003999 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1389489004000 RNA binding surface [nucleotide binding]; other site 1389489004001 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1389489004002 active site 1389489004003 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1389489004004 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1389489004005 HSP70 interaction site [polypeptide binding]; other site 1389489004006 Right handed beta helix region; Region: Beta_helix; pfam13229 1389489004007 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1389489004008 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1389489004009 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489004010 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1389489004011 nucleotide binding site [chemical binding]; other site 1389489004012 prenyltransferase; Reviewed; Region: ubiA; PRK13105 1389489004013 UbiA prenyltransferase family; Region: UbiA; pfam01040 1389489004014 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1389489004015 phytoene desaturase; Region: crtI_fam; TIGR02734 1389489004016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1389489004017 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1389489004018 substrate binding pocket [chemical binding]; other site 1389489004019 substrate-Mg2+ binding site; other site 1389489004020 aspartate-rich region 1; other site 1389489004021 aspartate-rich region 2; other site 1389489004022 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1389489004023 substrate binding pocket [chemical binding]; other site 1389489004024 chain length determination region; other site 1389489004025 substrate-Mg2+ binding site; other site 1389489004026 catalytic residues [active] 1389489004027 aspartate-rich region 1; other site 1389489004028 active site lid residues [active] 1389489004029 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1389489004030 aspartate-rich region 2; other site 1389489004031 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1389489004032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489004033 NAD(P) binding site [chemical binding]; other site 1389489004034 active site 1389489004035 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1389489004036 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1389489004037 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1389489004038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1389489004039 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1389489004040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1389489004041 DNA binding residues [nucleotide binding] 1389489004042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489004043 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 1389489004044 enterobactin exporter EntS; Provisional; Region: PRK10489 1389489004045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004046 dimer interface [polypeptide binding]; other site 1389489004047 conserved gate region; other site 1389489004048 ABC-ATPase subunit interface; other site 1389489004049 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1389489004050 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1389489004051 Walker A/P-loop; other site 1389489004052 ATP binding site [chemical binding]; other site 1389489004053 Q-loop/lid; other site 1389489004054 ABC transporter signature motif; other site 1389489004055 Walker B; other site 1389489004056 D-loop; other site 1389489004057 H-loop/switch region; other site 1389489004058 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1389489004059 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1389489004060 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1389489004061 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1389489004062 RNase_H superfamily; Region: RNase_H_2; pfam13482 1389489004063 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1389489004064 Part of AAA domain; Region: AAA_19; pfam13245 1389489004065 AAA domain; Region: AAA_12; pfam13087 1389489004066 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1389489004067 minor groove reading motif; other site 1389489004068 helix-hairpin-helix signature motif; other site 1389489004069 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1389489004070 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1389489004071 catalytic residues [active] 1389489004072 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1389489004073 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1389489004074 putative active site [active] 1389489004075 oxyanion strand; other site 1389489004076 catalytic triad [active] 1389489004077 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1389489004078 putative active site pocket [active] 1389489004079 4-fold oligomerization interface [polypeptide binding]; other site 1389489004080 metal binding residues [ion binding]; metal-binding site 1389489004081 3-fold/trimer interface [polypeptide binding]; other site 1389489004082 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1389489004083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489004084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489004085 homodimer interface [polypeptide binding]; other site 1389489004086 catalytic residue [active] 1389489004087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1389489004088 LexA repressor; Validated; Region: PRK00215 1389489004089 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1389489004090 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1389489004091 Catalytic site [active] 1389489004092 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1389489004093 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1389489004094 THF binding site; other site 1389489004095 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1389489004096 substrate binding site [chemical binding]; other site 1389489004097 THF binding site; other site 1389489004098 zinc-binding site [ion binding]; other site 1389489004099 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1389489004100 FAD binding site [chemical binding]; other site 1389489004101 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1389489004102 putative catalytic site [active] 1389489004103 putative phosphate binding site [ion binding]; other site 1389489004104 putative metal binding site [ion binding]; other site 1389489004105 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1389489004106 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489004107 Integrase core domain; Region: rve; pfam00665 1389489004108 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1389489004109 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1389489004110 homodimer interface [polypeptide binding]; other site 1389489004111 substrate-cofactor binding pocket; other site 1389489004112 catalytic residue [active] 1389489004113 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1389489004114 tartrate dehydrogenase; Region: TTC; TIGR02089 1389489004115 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1389489004116 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1389489004117 ligand binding site [chemical binding]; other site 1389489004118 NAD binding site [chemical binding]; other site 1389489004119 dimerization interface [polypeptide binding]; other site 1389489004120 catalytic site [active] 1389489004121 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1389489004122 putative L-serine binding site [chemical binding]; other site 1389489004123 CutC family; Region: CutC; cl01218 1389489004124 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1389489004125 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1389489004126 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1389489004127 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1389489004128 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1389489004129 putative valine binding site [chemical binding]; other site 1389489004130 dimer interface [polypeptide binding]; other site 1389489004131 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1389489004132 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1389489004133 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1389489004134 PYR/PP interface [polypeptide binding]; other site 1389489004135 dimer interface [polypeptide binding]; other site 1389489004136 TPP binding site [chemical binding]; other site 1389489004137 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1389489004138 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1389489004139 TPP-binding site [chemical binding]; other site 1389489004140 dimer interface [polypeptide binding]; other site 1389489004141 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1389489004142 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1389489004143 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1389489004144 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1389489004145 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1389489004146 active site 1389489004147 homotetramer interface [polypeptide binding]; other site 1389489004148 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1389489004149 active site 1389489004150 catalytic triad [active] 1389489004151 oxyanion hole [active] 1389489004152 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1389489004153 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1389489004154 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1389489004155 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1389489004156 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1389489004157 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1389489004158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1389489004159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1389489004160 DNA binding site [nucleotide binding] 1389489004161 domain linker motif; other site 1389489004162 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1389489004163 ligand binding site [chemical binding]; other site 1389489004164 dimerization interface [polypeptide binding]; other site 1389489004165 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1389489004166 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1389489004167 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1389489004168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489004169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004170 dimer interface [polypeptide binding]; other site 1389489004171 conserved gate region; other site 1389489004172 putative PBP binding loops; other site 1389489004173 ABC-ATPase subunit interface; other site 1389489004174 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1389489004175 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1389489004176 active site 1389489004177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1389489004178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1389489004179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1389489004180 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1389489004181 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1389489004182 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1389489004183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489004184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004185 dimer interface [polypeptide binding]; other site 1389489004186 conserved gate region; other site 1389489004187 putative PBP binding loops; other site 1389489004188 ABC-ATPase subunit interface; other site 1389489004189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1389489004190 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1389489004191 putative DNA binding site [nucleotide binding]; other site 1389489004192 putative Zn2+ binding site [ion binding]; other site 1389489004193 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489004194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1389489004195 Integrase core domain; Region: rve; pfam00665 1389489004196 Integrase core domain; Region: rve_3; pfam13683 1389489004197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1389489004198 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1389489004199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489004200 Walker A/P-loop; other site 1389489004201 ATP binding site [chemical binding]; other site 1389489004202 Q-loop/lid; other site 1389489004203 ABC transporter signature motif; other site 1389489004204 Walker B; other site 1389489004205 D-loop; other site 1389489004206 H-loop/switch region; other site 1389489004207 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1389489004208 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1389489004209 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1389489004210 trimerization site [polypeptide binding]; other site 1389489004211 active site 1389489004212 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1389489004213 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1389489004214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489004215 catalytic residue [active] 1389489004216 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489004217 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489004218 Integrase core domain; Region: rve; pfam00665 1389489004219 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1389489004220 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1389489004221 active site 1389489004222 zinc binding site [ion binding]; other site 1389489004223 Transposase; Region: HTH_Tnp_1; cl17663 1389489004224 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1389489004225 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; Region: PGM_PMM_I; pfam02878 1389489004226 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1389489004227 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489004228 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489004229 Helix-turn-helix domain; Region: HTH_17; pfam12728 1389489004230 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1389489004231 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1389489004232 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1389489004233 HIGH motif; other site 1389489004234 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1389489004235 active site 1389489004236 KMSKS motif; other site 1389489004237 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1389489004238 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1389489004239 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1389489004240 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1389489004241 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1389489004242 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1389489004243 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489004244 Integrase core domain; Region: rve; pfam00665 1389489004245 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1389489004246 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1389489004247 HflX GTPase family; Region: HflX; cd01878 1389489004248 G1 box; other site 1389489004249 GTP/Mg2+ binding site [chemical binding]; other site 1389489004250 Switch I region; other site 1389489004251 G2 box; other site 1389489004252 G3 box; other site 1389489004253 Switch II region; other site 1389489004254 G4 box; other site 1389489004255 G5 box; other site 1389489004256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1389489004257 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1389489004258 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1389489004259 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1389489004260 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1389489004261 IPP transferase; Region: IPPT; pfam01715 1389489004262 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1389489004263 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1389489004264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1389489004265 FeS/SAM binding site; other site 1389489004266 Integrase core domain; Region: rve; pfam00665 1389489004267 Integrase core domain; Region: rve_3; pfam13683 1389489004268 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1389489004269 recombinase A; Provisional; Region: recA; PRK09354 1389489004270 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1389489004271 hexamer interface [polypeptide binding]; other site 1389489004272 Walker A motif; other site 1389489004273 ATP binding site [chemical binding]; other site 1389489004274 Walker B motif; other site 1389489004275 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1389489004276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489004277 non-specific DNA binding site [nucleotide binding]; other site 1389489004278 salt bridge; other site 1389489004279 sequence-specific DNA binding site [nucleotide binding]; other site 1389489004280 Competence-damaged protein; Region: CinA; pfam02464 1389489004281 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1389489004282 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1389489004283 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1389489004284 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1389489004285 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1389489004286 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1389489004287 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1389489004288 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1389489004289 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1389489004290 dimer interface [polypeptide binding]; other site 1389489004291 active site 1389489004292 catalytic residue [active] 1389489004293 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1389489004294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489004295 TIGR01777 family protein; Region: yfcH 1389489004296 NAD(P) binding site [chemical binding]; other site 1389489004297 active site 1389489004298 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1389489004299 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1389489004300 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1389489004301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1389489004302 catalytic core [active] 1389489004303 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1389489004304 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1389489004305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1389489004306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1389489004307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489004308 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1389489004309 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1389489004310 active site 1389489004311 catalytic tetrad [active] 1389489004312 Penicillin amidase; Region: Penicil_amidase; pfam01804 1389489004313 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1389489004314 active site 1389489004315 Penicillin amidase; Region: Penicil_amidase; pfam01804 1389489004316 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1389489004317 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1389489004318 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1389489004319 dimer interface [polypeptide binding]; other site 1389489004320 active site 1389489004321 citrylCoA binding site [chemical binding]; other site 1389489004322 NADH binding [chemical binding]; other site 1389489004323 cationic pore residues; other site 1389489004324 oxalacetate/citrate binding site [chemical binding]; other site 1389489004325 coenzyme A binding site [chemical binding]; other site 1389489004326 catalytic triad [active] 1389489004327 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1389489004328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489004329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489004330 homodimer interface [polypeptide binding]; other site 1389489004331 catalytic residue [active] 1389489004332 Ferredoxin [Energy production and conversion]; Region: COG1146 1389489004333 4Fe-4S binding domain; Region: Fer4; pfam00037 1389489004334 Iron permease FTR1 family; Region: FTR1; cl00475 1389489004335 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1389489004336 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1389489004337 Imelysin; Region: Peptidase_M75; pfam09375 1389489004338 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1389489004339 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1389489004340 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1389489004341 G1 box; other site 1389489004342 putative GEF interaction site [polypeptide binding]; other site 1389489004343 GTP/Mg2+ binding site [chemical binding]; other site 1389489004344 Switch I region; other site 1389489004345 G2 box; other site 1389489004346 G3 box; other site 1389489004347 Switch II region; other site 1389489004348 G4 box; other site 1389489004349 G5 box; other site 1389489004350 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1389489004351 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1389489004352 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1389489004353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489004354 Walker A/P-loop; other site 1389489004355 ATP binding site [chemical binding]; other site 1389489004356 Q-loop/lid; other site 1389489004357 ABC transporter signature motif; other site 1389489004358 Walker B; other site 1389489004359 D-loop; other site 1389489004360 H-loop/switch region; other site 1389489004361 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489004362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489004363 Walker A/P-loop; other site 1389489004364 ATP binding site [chemical binding]; other site 1389489004365 Q-loop/lid; other site 1389489004366 ABC transporter signature motif; other site 1389489004367 Walker B; other site 1389489004368 D-loop; other site 1389489004369 H-loop/switch region; other site 1389489004370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489004371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1389489004372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004373 dimer interface [polypeptide binding]; other site 1389489004374 conserved gate region; other site 1389489004375 putative PBP binding loops; other site 1389489004376 ABC-ATPase subunit interface; other site 1389489004377 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1389489004378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004379 dimer interface [polypeptide binding]; other site 1389489004380 conserved gate region; other site 1389489004381 putative PBP binding loops; other site 1389489004382 ABC-ATPase subunit interface; other site 1389489004383 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1389489004384 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489004385 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1389489004386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489004387 Walker A/P-loop; other site 1389489004388 ATP binding site [chemical binding]; other site 1389489004389 Q-loop/lid; other site 1389489004390 ABC transporter signature motif; other site 1389489004391 Walker B; other site 1389489004392 D-loop; other site 1389489004393 H-loop/switch region; other site 1389489004394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489004395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489004396 Walker A/P-loop; other site 1389489004397 ATP binding site [chemical binding]; other site 1389489004398 Q-loop/lid; other site 1389489004399 ABC transporter signature motif; other site 1389489004400 Walker B; other site 1389489004401 D-loop; other site 1389489004402 H-loop/switch region; other site 1389489004403 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489004404 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1389489004405 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1389489004406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004407 dimer interface [polypeptide binding]; other site 1389489004408 conserved gate region; other site 1389489004409 putative PBP binding loops; other site 1389489004410 ABC-ATPase subunit interface; other site 1389489004411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1389489004412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004413 dimer interface [polypeptide binding]; other site 1389489004414 ABC-ATPase subunit interface; other site 1389489004415 putative PBP binding loops; other site 1389489004416 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1389489004417 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1389489004418 glycine dehydrogenase; Provisional; Region: PRK05367 1389489004419 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1389489004420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489004421 catalytic residue [active] 1389489004422 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1389489004423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489004424 catalytic residue [active] 1389489004425 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1389489004426 lipoyl attachment site [posttranslational modification]; other site 1389489004427 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1389489004428 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1389489004429 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1389489004430 nudix motif; other site 1389489004431 quinolinate synthetase; Provisional; Region: PRK09375 1389489004432 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1389489004433 L-aspartate oxidase; Provisional; Region: PRK06175 1389489004434 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1389489004435 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 1389489004436 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1389489004437 dimerization interface [polypeptide binding]; other site 1389489004438 active site 1389489004439 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1389489004440 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1389489004441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489004442 catalytic residue [active] 1389489004443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489004444 putative substrate translocation pore; other site 1389489004445 NYN domain; Region: NYN; pfam01936 1389489004446 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1389489004447 putative metal binding site [ion binding]; other site 1389489004448 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1389489004449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1389489004450 GTP-binding protein YchF; Reviewed; Region: PRK09601 1389489004451 YchF GTPase; Region: YchF; cd01900 1389489004452 G1 box; other site 1389489004453 GTP/Mg2+ binding site [chemical binding]; other site 1389489004454 Switch I region; other site 1389489004455 G2 box; other site 1389489004456 Switch II region; other site 1389489004457 G3 box; other site 1389489004458 G4 box; other site 1389489004459 G5 box; other site 1389489004460 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1389489004461 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1389489004462 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1389489004463 Integrase core domain; Region: rve; pfam00665 1389489004464 Integrase core domain; Region: rve_3; pfam13683 1389489004465 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1389489004466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489004467 putative substrate translocation pore; other site 1389489004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489004469 RmuC family; Region: RmuC; pfam02646 1389489004470 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1389489004471 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1389489004472 putative active site [active] 1389489004473 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1389489004474 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1389489004475 active site 1389489004476 intersubunit interface [polypeptide binding]; other site 1389489004477 zinc binding site [ion binding]; other site 1389489004478 Na+ binding site [ion binding]; other site 1389489004479 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1389489004480 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1389489004481 NADP binding site [chemical binding]; other site 1389489004482 Predicted transcriptional regulators [Transcription]; Region: COG1733 1389489004483 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1389489004484 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1389489004485 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1389489004486 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1389489004487 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1389489004488 generic binding surface II; other site 1389489004489 generic binding surface I; other site 1389489004490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1389489004491 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1389489004492 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1389489004493 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1389489004494 active site clefts [active] 1389489004495 zinc binding site [ion binding]; other site 1389489004496 dimer interface [polypeptide binding]; other site 1389489004497 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1389489004498 Class II fumarases; Region: Fumarase_classII; cd01362 1389489004499 active site 1389489004500 tetramer interface [polypeptide binding]; other site 1389489004501 Integrase core domain; Region: rve; pfam00665 1389489004502 Integrase core domain; Region: rve_3; pfam13683 1389489004503 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489004504 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1389489004505 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1389489004506 putative active site [active] 1389489004507 PhoH-like protein; Region: PhoH; pfam02562 1389489004508 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1389489004509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1389489004510 catalytic residue [active] 1389489004511 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1389489004512 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1389489004513 catalytic residue [active] 1389489004514 putative FPP diphosphate binding site; other site 1389489004515 putative FPP binding hydrophobic cleft; other site 1389489004516 dimer interface [polypeptide binding]; other site 1389489004517 putative IPP diphosphate binding site; other site 1389489004518 Haemolysin-III related; Region: HlyIII; pfam03006 1389489004519 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1389489004520 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1389489004521 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1389489004522 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1389489004523 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1389489004524 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1389489004525 threonine dehydratase; Provisional; Region: PRK08198 1389489004526 tetramer interface [polypeptide binding]; other site 1389489004527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489004528 catalytic residue [active] 1389489004529 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1389489004530 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1389489004531 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1389489004532 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1389489004533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1389489004534 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1389489004535 Peptidase family M48; Region: Peptidase_M48; cl12018 1389489004536 Integrase core domain; Region: rve; pfam00665 1389489004537 Integrase core domain; Region: rve_3; pfam13683 1389489004538 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1389489004539 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1389489004540 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1389489004541 Phage-related protein [Function unknown]; Region: COG5412 1389489004542 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489004543 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1389489004544 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1389489004545 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1389489004546 Integrase core domain; Region: rve; pfam00665 1389489004547 Integrase core domain; Region: rve_3; pfam13683 1389489004548 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1389489004549 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1389489004550 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1389489004551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1389489004552 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1389489004553 active site 1389489004554 catalytic residues [active] 1389489004555 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1389489004556 Septum formation initiator; Region: DivIC; pfam04977 1389489004557 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1389489004558 enolase; Provisional; Region: eno; PRK00077 1389489004559 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1389489004560 dimer interface [polypeptide binding]; other site 1389489004561 metal binding site [ion binding]; metal-binding site 1389489004562 substrate binding pocket [chemical binding]; other site 1389489004563 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1389489004564 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1389489004565 dimer interface [polypeptide binding]; other site 1389489004566 motif 1; other site 1389489004567 active site 1389489004568 motif 2; other site 1389489004569 motif 3; other site 1389489004570 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1389489004571 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1389489004572 siderophore binding site; other site 1389489004573 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 1389489004574 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1389489004575 homodimer interface [polypeptide binding]; other site 1389489004576 metal binding site [ion binding]; metal-binding site 1389489004577 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1389489004578 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1389489004579 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1389489004580 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1389489004581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489004582 ATP binding site [chemical binding]; other site 1389489004583 putative Mg++ binding site [ion binding]; other site 1389489004584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489004585 nucleotide binding region [chemical binding]; other site 1389489004586 ATP-binding site [chemical binding]; other site 1389489004587 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1389489004588 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1389489004589 putative active site [active] 1389489004590 catalytic residue [active] 1389489004591 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1389489004592 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1389489004593 5S rRNA interface [nucleotide binding]; other site 1389489004594 CTC domain interface [polypeptide binding]; other site 1389489004595 L16 interface [polypeptide binding]; other site 1389489004596 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1389489004597 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1389489004598 metal binding site [ion binding]; metal-binding site 1389489004599 substrate binding pocket [chemical binding]; other site 1389489004600 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1389489004601 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1389489004602 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1389489004603 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1389489004604 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489004605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004606 dimer interface [polypeptide binding]; other site 1389489004607 conserved gate region; other site 1389489004608 putative PBP binding loops; other site 1389489004609 ABC-ATPase subunit interface; other site 1389489004610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004611 dimer interface [polypeptide binding]; other site 1389489004612 conserved gate region; other site 1389489004613 putative PBP binding loops; other site 1389489004614 ABC-ATPase subunit interface; other site 1389489004615 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1389489004616 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1389489004617 Glucuronate isomerase; Region: UxaC; cl00829 1389489004618 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1389489004619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1389489004620 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1389489004621 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1389489004622 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1389489004623 Coenzyme A binding pocket [chemical binding]; other site 1389489004624 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1389489004625 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489004626 hypothetical protein; Validated; Region: PRK02101 1389489004627 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1389489004628 AAA domain; Region: AAA_33; pfam13671 1389489004629 active site 1389489004630 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1389489004631 gamma subunit interface [polypeptide binding]; other site 1389489004632 epsilon subunit interface [polypeptide binding]; other site 1389489004633 LBP interface [polypeptide binding]; other site 1389489004634 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1389489004635 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1389489004636 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1389489004637 alpha subunit interaction interface [polypeptide binding]; other site 1389489004638 Walker A motif; other site 1389489004639 ATP binding site [chemical binding]; other site 1389489004640 Walker B motif; other site 1389489004641 inhibitor binding site; inhibition site 1389489004642 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1389489004643 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1389489004644 core domain interface [polypeptide binding]; other site 1389489004645 delta subunit interface [polypeptide binding]; other site 1389489004646 epsilon subunit interface [polypeptide binding]; other site 1389489004647 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1389489004648 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1389489004649 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1389489004650 beta subunit interaction interface [polypeptide binding]; other site 1389489004651 Walker A motif; other site 1389489004652 ATP binding site [chemical binding]; other site 1389489004653 Walker B motif; other site 1389489004654 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1389489004655 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1389489004656 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1389489004657 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1389489004658 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1389489004659 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1389489004660 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1389489004661 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1389489004662 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1389489004663 Mg++ binding site [ion binding]; other site 1389489004664 putative catalytic motif [active] 1389489004665 substrate binding site [chemical binding]; other site 1389489004666 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1389489004667 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1389489004668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489004669 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1389489004670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489004671 S-adenosylmethionine binding site [chemical binding]; other site 1389489004672 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1389489004673 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1389489004674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489004675 serine O-acetyltransferase; Region: cysE; TIGR01172 1389489004676 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1389489004677 trimer interface [polypeptide binding]; other site 1389489004678 active site 1389489004679 substrate binding site [chemical binding]; other site 1389489004680 CoA binding site [chemical binding]; other site 1389489004681 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1389489004682 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1389489004683 RF-1 domain; Region: RF-1; pfam00472 1389489004684 Transcription termination factor [Transcription]; Region: Rho; COG1158 1389489004685 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1389489004686 RNA binding site [nucleotide binding]; other site 1389489004687 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1389489004688 multimer interface [polypeptide binding]; other site 1389489004689 Walker A motif; other site 1389489004690 ATP binding site [chemical binding]; other site 1389489004691 Walker B motif; other site 1389489004692 homoserine kinase; Provisional; Region: PRK01212 1389489004693 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1389489004694 threonine synthase; Reviewed; Region: PRK06721 1389489004695 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1389489004696 homodimer interface [polypeptide binding]; other site 1389489004697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489004698 catalytic residue [active] 1389489004699 homoserine dehydrogenase; Provisional; Region: PRK06349 1389489004700 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1389489004701 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1389489004702 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1389489004703 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1389489004704 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1389489004705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1389489004706 catalytic residue [active] 1389489004707 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1389489004708 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1389489004709 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1389489004710 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1389489004711 active site 1389489004712 HIGH motif; other site 1389489004713 KMSK motif region; other site 1389489004714 tRNA binding surface [nucleotide binding]; other site 1389489004715 DALR anticodon binding domain; Region: DALR_1; smart00836 1389489004716 anticodon binding site; other site 1389489004717 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1389489004718 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1389489004719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004720 dimer interface [polypeptide binding]; other site 1389489004721 conserved gate region; other site 1389489004722 putative PBP binding loops; other site 1389489004723 ABC-ATPase subunit interface; other site 1389489004724 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1389489004725 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1389489004726 putative NAD(P) binding site [chemical binding]; other site 1389489004727 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1389489004728 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1389489004729 Peptidase family M23; Region: Peptidase_M23; pfam01551 1389489004730 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1389489004731 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489004732 DNA-binding site [nucleotide binding]; DNA binding site 1389489004733 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1389489004734 putative substrate binding site [chemical binding]; other site 1389489004735 putative ATP binding site [chemical binding]; other site 1389489004736 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 1389489004737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489004738 S-adenosylmethionine binding site [chemical binding]; other site 1389489004739 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1389489004740 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1389489004741 SelR domain; Region: SelR; pfam01641 1389489004742 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1389489004743 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1389489004744 putative NAD(P) binding site [chemical binding]; other site 1389489004745 active site 1389489004746 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1389489004747 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1389489004748 catalytic triad [active] 1389489004749 Repair protein; Region: Repair_PSII; pfam04536 1389489004750 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1389489004751 enoyl-CoA hydratase; Provisional; Region: PRK06563 1389489004752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1389489004753 substrate binding site [chemical binding]; other site 1389489004754 oxyanion hole (OAH) forming residues; other site 1389489004755 trimer interface [polypeptide binding]; other site 1389489004756 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1389489004757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489004758 NAD(P) binding site [chemical binding]; other site 1389489004759 active site 1389489004760 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1389489004761 Integrase core domain; Region: rve; pfam00665 1389489004762 Integrase core domain; Region: rve_3; pfam13683 1389489004763 Transglycosylase; Region: Transgly; pfam00912 1389489004764 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1389489004765 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1389489004766 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489004767 membrane protein insertase; Provisional; Region: PRK01318 1389489004768 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489004769 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1389489004770 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489004771 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1389489004772 CGNR zinc finger; Region: zf-CGNR; pfam11706 1389489004773 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1389489004774 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1389489004775 putative catalytic site [active] 1389489004776 putative metal binding site [ion binding]; other site 1389489004777 putative phosphate binding site [ion binding]; other site 1389489004778 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1389489004779 nucleotide binding site [chemical binding]; other site 1389489004780 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 1389489004781 Siderophore-interacting protein; Region: SIP; pfam04954 1389489004782 Integrase core domain; Region: rve_3; cl15866 1389489004783 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1389489004784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1389489004785 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1389489004786 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1389489004787 active site 1389489004788 tetramer interface; other site 1389489004789 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1389489004790 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1389489004791 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1389489004792 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1389489004793 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1389489004794 Part of AAA domain; Region: AAA_19; pfam13245 1389489004795 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1389489004796 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1389489004797 NlpC/P60 family; Region: NLPC_P60; pfam00877 1389489004798 Isochorismatase family; Region: Isochorismatase; pfam00857 1389489004799 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1389489004800 catalytic triad [active] 1389489004801 conserved cis-peptide bond; other site 1389489004802 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1389489004803 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1389489004804 catalytic residues [active] 1389489004805 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1389489004806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489004807 putative substrate translocation pore; other site 1389489004808 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1389489004809 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1389489004810 Bacterial transcriptional regulator; Region: IclR; pfam01614 1389489004811 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 1389489004812 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1389489004813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1389489004814 succinic semialdehyde dehydrogenase; Region: PLN02278 1389489004815 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1389489004816 tetramerization interface [polypeptide binding]; other site 1389489004817 NAD(P) binding site [chemical binding]; other site 1389489004818 catalytic residues [active] 1389489004819 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1389489004820 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1389489004821 NADP binding site [chemical binding]; other site 1389489004822 homodimer interface [polypeptide binding]; other site 1389489004823 active site 1389489004824 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1389489004825 FAD binding domain; Region: FAD_binding_4; pfam01565 1389489004826 Integrase core domain; Region: rve; pfam00665 1389489004827 Integrase core domain; Region: rve_3; pfam13683 1389489004828 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004830 dimer interface [polypeptide binding]; other site 1389489004831 conserved gate region; other site 1389489004832 ABC-ATPase subunit interface; other site 1389489004833 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1389489004834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489004835 conserved gate region; other site 1389489004836 putative PBP binding loops; other site 1389489004837 ABC-ATPase subunit interface; other site 1389489004838 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1389489004839 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1389489004840 DNA binding site [nucleotide binding] 1389489004841 domain linker motif; other site 1389489004842 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1389489004843 dimerization interface [polypeptide binding]; other site 1389489004844 ligand binding site [chemical binding]; other site 1389489004845 GTP-binding protein Der; Reviewed; Region: PRK03003 1389489004846 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1389489004847 G1 box; other site 1389489004848 GTP/Mg2+ binding site [chemical binding]; other site 1389489004849 Switch I region; other site 1389489004850 G2 box; other site 1389489004851 Switch II region; other site 1389489004852 G3 box; other site 1389489004853 G4 box; other site 1389489004854 G5 box; other site 1389489004855 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1389489004856 G1 box; other site 1389489004857 GTP/Mg2+ binding site [chemical binding]; other site 1389489004858 Switch I region; other site 1389489004859 G2 box; other site 1389489004860 G3 box; other site 1389489004861 Switch II region; other site 1389489004862 G4 box; other site 1389489004863 G5 box; other site 1389489004864 cytidylate kinase; Provisional; Region: cmk; PRK00023 1389489004865 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1389489004866 CMP-binding site; other site 1389489004867 The sites determining sugar specificity; other site 1389489004868 prephenate dehydrogenase; Validated; Region: PRK06545 1389489004869 prephenate dehydrogenase; Validated; Region: PRK08507 1389489004870 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1389489004871 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1389489004872 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1389489004873 RNA binding surface [nucleotide binding]; other site 1389489004874 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1389489004875 active site 1389489004876 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1389489004877 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1389489004878 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1389489004879 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1389489004880 P-loop; other site 1389489004881 Magnesium ion binding site [ion binding]; other site 1389489004882 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1389489004883 Magnesium ion binding site [ion binding]; other site 1389489004884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1389489004885 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1389489004886 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489004887 active site 1389489004888 DNA binding site [nucleotide binding] 1389489004889 Int/Topo IB signature motif; other site 1389489004890 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1389489004891 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1389489004892 dimer interface [polypeptide binding]; other site 1389489004893 ADP-ribose binding site [chemical binding]; other site 1389489004894 active site 1389489004895 nudix motif; other site 1389489004896 metal binding site [ion binding]; metal-binding site 1389489004897 CTP synthetase; Validated; Region: pyrG; PRK05380 1389489004898 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1389489004899 Catalytic site [active] 1389489004900 active site 1389489004901 UTP binding site [chemical binding]; other site 1389489004902 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1389489004903 active site 1389489004904 putative oxyanion hole; other site 1389489004905 catalytic triad [active] 1389489004906 Integrase core domain; Region: rve_3; cl15866 1389489004907 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1389489004908 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1389489004909 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1389489004910 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1389489004911 Walker A/P-loop; other site 1389489004912 ATP binding site [chemical binding]; other site 1389489004913 Q-loop/lid; other site 1389489004914 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1389489004915 ABC transporter signature motif; other site 1389489004916 Walker B; other site 1389489004917 D-loop; other site 1389489004918 H-loop/switch region; other site 1389489004919 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1389489004920 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1389489004921 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1389489004922 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1389489004923 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1389489004924 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1389489004925 FliW protein; Region: FliW; cl00740 1389489004926 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1389489004927 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1389489004928 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489004929 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1389489004930 putative ADP-binding pocket [chemical binding]; other site 1389489004931 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1389489004932 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1389489004933 active site 1389489004934 HIGH motif; other site 1389489004935 dimer interface [polypeptide binding]; other site 1389489004936 KMSKS motif; other site 1389489004937 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1389489004938 RNA binding surface [nucleotide binding]; other site 1389489004939 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1389489004940 active site 1389489004941 DNA binding site [nucleotide binding] 1389489004942 argininosuccinate lyase; Provisional; Region: PRK00855 1389489004943 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1389489004944 active sites [active] 1389489004945 tetramer interface [polypeptide binding]; other site 1389489004946 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1389489004947 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1389489004948 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1389489004949 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1389489004950 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1389489004951 inhibitor-cofactor binding pocket; inhibition site 1389489004952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489004953 catalytic residue [active] 1389489004954 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1389489004955 homohexameric interface [polypeptide binding]; other site 1389489004956 feedback inhibition sensing region; other site 1389489004957 nucleotide binding site [chemical binding]; other site 1389489004958 N-acetyl-L-glutamate binding site [chemical binding]; other site 1389489004959 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1389489004960 heterotetramer interface [polypeptide binding]; other site 1389489004961 active site pocket [active] 1389489004962 cleavage site 1389489004963 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1389489004964 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1389489004965 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1389489004966 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1389489004967 putative tRNA-binding site [nucleotide binding]; other site 1389489004968 B3/4 domain; Region: B3_4; pfam03483 1389489004969 tRNA synthetase B5 domain; Region: B5; smart00874 1389489004970 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1389489004971 dimer interface [polypeptide binding]; other site 1389489004972 motif 1; other site 1389489004973 motif 3; other site 1389489004974 motif 2; other site 1389489004975 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1389489004976 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1389489004977 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1389489004978 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1389489004979 dimer interface [polypeptide binding]; other site 1389489004980 motif 1; other site 1389489004981 active site 1389489004982 motif 2; other site 1389489004983 motif 3; other site 1389489004984 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1389489004985 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1389489004986 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1389489004987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489004988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489004989 active site 1389489004990 phosphorylation site [posttranslational modification] 1389489004991 intermolecular recognition site; other site 1389489004992 dimerization interface [polypeptide binding]; other site 1389489004993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489004994 DNA binding site [nucleotide binding] 1389489004995 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1389489004996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489004997 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1389489004998 Walker A/P-loop; other site 1389489004999 ATP binding site [chemical binding]; other site 1389489005000 Q-loop/lid; other site 1389489005001 ABC transporter signature motif; other site 1389489005002 Walker B; other site 1389489005003 D-loop; other site 1389489005004 H-loop/switch region; other site 1389489005005 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1389489005006 23S rRNA binding site [nucleotide binding]; other site 1389489005007 L21 binding site [polypeptide binding]; other site 1389489005008 L13 binding site [polypeptide binding]; other site 1389489005009 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1389489005010 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1389489005011 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1389489005012 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1389489005013 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1389489005014 Amidase; Region: Amidase; cl11426 1389489005015 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1389489005016 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1389489005017 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1389489005018 ligand binding site [chemical binding]; other site 1389489005019 active site 1389489005020 UGI interface [polypeptide binding]; other site 1389489005021 catalytic site [active] 1389489005022 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1389489005023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489005024 active site 1389489005025 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1389489005026 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1389489005027 homodimer interface [polypeptide binding]; other site 1389489005028 substrate-cofactor binding pocket; other site 1389489005029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489005030 catalytic residue [active] 1389489005031 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1389489005032 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489005033 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1389489005034 ATP binding site [chemical binding]; other site 1389489005035 Mg2+ binding site [ion binding]; other site 1389489005036 G-X-G motif; other site 1389489005037 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489005038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1389489005039 active site 1389489005040 dimerization interface [polypeptide binding]; other site 1389489005041 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1389489005042 DNA binding residues [nucleotide binding] 1389489005043 Chorismate mutase type II; Region: CM_2; cl00693 1389489005044 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1389489005045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005046 putative substrate translocation pore; other site 1389489005047 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1389489005048 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1389489005049 Catalytic site [active] 1389489005050 Domain of unknown function DUF77; Region: DUF77; pfam01910 1389489005051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1389489005052 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1389489005053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489005054 motif II; other site 1389489005055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1389489005056 phosphate binding site [ion binding]; other site 1389489005057 Domain of unknown function DUF21; Region: DUF21; pfam01595 1389489005058 FOG: CBS domain [General function prediction only]; Region: COG0517 1389489005059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1389489005060 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1389489005061 Domain of unknown function DUF21; Region: DUF21; pfam01595 1389489005062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1389489005063 Transporter associated domain; Region: CorC_HlyC; smart01091 1389489005064 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1389489005065 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1389489005066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1389489005067 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1389489005068 active site 1389489005069 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1389489005070 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1389489005071 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1389489005072 TPP-binding site [chemical binding]; other site 1389489005073 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1389489005074 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1389489005075 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1389489005076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1389489005077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1389489005078 DNA binding residues [nucleotide binding] 1389489005079 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1389489005080 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1389489005081 active site 1389489005082 hinge; other site 1389489005083 Predicted GTPases [General function prediction only]; Region: COG1162 1389489005084 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1389489005085 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1389489005086 GTP/Mg2+ binding site [chemical binding]; other site 1389489005087 G4 box; other site 1389489005088 G5 box; other site 1389489005089 G1 box; other site 1389489005090 Switch I region; other site 1389489005091 G2 box; other site 1389489005092 G3 box; other site 1389489005093 Switch II region; other site 1389489005094 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1389489005095 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1389489005096 catalytic triad [active] 1389489005097 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1389489005098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489005099 Walker A/P-loop; other site 1389489005100 ATP binding site [chemical binding]; other site 1389489005101 Q-loop/lid; other site 1389489005102 ABC transporter signature motif; other site 1389489005103 Walker B; other site 1389489005104 D-loop; other site 1389489005105 H-loop/switch region; other site 1389489005106 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489005107 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1389489005108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489005109 Walker A/P-loop; other site 1389489005110 ATP binding site [chemical binding]; other site 1389489005111 Q-loop/lid; other site 1389489005112 ABC transporter signature motif; other site 1389489005113 Walker B; other site 1389489005114 D-loop; other site 1389489005115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489005116 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1389489005117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489005118 dimer interface [polypeptide binding]; other site 1389489005119 conserved gate region; other site 1389489005120 putative PBP binding loops; other site 1389489005121 ABC-ATPase subunit interface; other site 1389489005122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1389489005123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489005124 dimer interface [polypeptide binding]; other site 1389489005125 conserved gate region; other site 1389489005126 putative PBP binding loops; other site 1389489005127 ABC-ATPase subunit interface; other site 1389489005128 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1389489005129 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1389489005130 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1389489005131 Transcription factor WhiB; Region: Whib; pfam02467 1389489005132 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1389489005133 PAS fold; Region: PAS_4; pfam08448 1389489005134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1389489005135 Histidine kinase; Region: HisKA_2; pfam07568 1389489005136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489005137 ATP binding site [chemical binding]; other site 1389489005138 Mg2+ binding site [ion binding]; other site 1389489005139 G-X-G motif; other site 1389489005140 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1389489005141 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1389489005142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1389489005143 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1389489005144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1389489005145 nucleotide binding region [chemical binding]; other site 1389489005146 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1389489005147 30S subunit binding site; other site 1389489005148 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1389489005149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489005150 active site 1389489005151 lipoprotein LpqB; Provisional; Region: PRK13615 1389489005152 Sporulation and spore germination; Region: Germane; pfam10646 1389489005153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1389489005154 dimerization interface [polypeptide binding]; other site 1389489005155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1389489005156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1389489005157 dimer interface [polypeptide binding]; other site 1389489005158 phosphorylation site [posttranslational modification] 1389489005159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489005160 ATP binding site [chemical binding]; other site 1389489005161 Mg2+ binding site [ion binding]; other site 1389489005162 G-X-G motif; other site 1389489005163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489005164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489005165 active site 1389489005166 phosphorylation site [posttranslational modification] 1389489005167 intermolecular recognition site; other site 1389489005168 dimerization interface [polypeptide binding]; other site 1389489005169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489005170 DNA binding site [nucleotide binding] 1389489005171 MoxR-like ATPases [General function prediction only]; Region: COG0714 1389489005172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489005173 Walker A motif; other site 1389489005174 ATP binding site [chemical binding]; other site 1389489005175 Walker B motif; other site 1389489005176 arginine finger; other site 1389489005177 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1389489005178 Protein of unknown function DUF58; Region: DUF58; pfam01882 1389489005179 Integral membrane protein DUF95; Region: DUF95; pfam01944 1389489005180 RDD family; Region: RDD; pfam06271 1389489005181 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1389489005182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1389489005183 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1389489005184 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1389489005185 homotetramer interface [polypeptide binding]; other site 1389489005186 ligand binding site [chemical binding]; other site 1389489005187 catalytic site [active] 1389489005188 NAD binding site [chemical binding]; other site 1389489005189 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1389489005190 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1389489005191 active site 1389489005192 substrate binding site [chemical binding]; other site 1389489005193 metal binding site [ion binding]; metal-binding site 1389489005194 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1389489005195 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1389489005196 PBP superfamily domain; Region: PBP_like_2; cl17296 1389489005197 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1389489005198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489005199 dimer interface [polypeptide binding]; other site 1389489005200 conserved gate region; other site 1389489005201 putative PBP binding loops; other site 1389489005202 ABC-ATPase subunit interface; other site 1389489005203 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1389489005204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489005205 dimer interface [polypeptide binding]; other site 1389489005206 conserved gate region; other site 1389489005207 putative PBP binding loops; other site 1389489005208 ABC-ATPase subunit interface; other site 1389489005209 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1389489005210 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1389489005211 Walker A/P-loop; other site 1389489005212 ATP binding site [chemical binding]; other site 1389489005213 Q-loop/lid; other site 1389489005214 ABC transporter signature motif; other site 1389489005215 Walker B; other site 1389489005216 D-loop; other site 1389489005217 H-loop/switch region; other site 1389489005218 RNA polymerase sigma factor; Provisional; Region: PRK12534 1389489005219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1389489005220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1389489005221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489005222 non-specific DNA binding site [nucleotide binding]; other site 1389489005223 salt bridge; other site 1389489005224 sequence-specific DNA binding site [nucleotide binding]; other site 1389489005225 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1389489005226 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1389489005227 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1389489005228 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1389489005229 Phage capsid family; Region: Phage_capsid; pfam05065 1389489005230 Phage capsid family; Region: Phage_capsid; pfam05065 1389489005231 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1389489005232 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1389489005233 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489005234 active site 1389489005235 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1389489005236 active site 1389489005237 oxyanion hole [active] 1389489005238 catalytic triad [active] 1389489005239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489005240 active site 1389489005241 DNA binding site [nucleotide binding] 1389489005242 Int/Topo IB signature motif; other site 1389489005243 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1389489005244 Cl- selectivity filter; other site 1389489005245 Cl- binding residues [ion binding]; other site 1389489005246 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1389489005247 pore gating glutamate residue; other site 1389489005248 dimer interface [polypeptide binding]; other site 1389489005249 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1389489005250 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1389489005251 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1389489005252 Integrase core domain; Region: rve; pfam00665 1389489005253 Integrase core domain; Region: rve_3; pfam13683 1389489005254 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1389489005255 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1389489005256 active site 1389489005257 substrate binding site [chemical binding]; other site 1389489005258 metal binding site [ion binding]; metal-binding site 1389489005259 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1389489005260 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1389489005261 23S rRNA interface [nucleotide binding]; other site 1389489005262 L3 interface [polypeptide binding]; other site 1389489005263 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1389489005264 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1389489005265 dimerization interface 3.5A [polypeptide binding]; other site 1389489005266 active site 1389489005267 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1389489005268 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1389489005269 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1389489005270 alphaNTD homodimer interface [polypeptide binding]; other site 1389489005271 alphaNTD - beta interaction site [polypeptide binding]; other site 1389489005272 alphaNTD - beta' interaction site [polypeptide binding]; other site 1389489005273 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1389489005274 30S ribosomal protein S11; Validated; Region: PRK05309 1389489005275 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1389489005276 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1389489005277 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1389489005278 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1389489005279 rRNA binding site [nucleotide binding]; other site 1389489005280 predicted 30S ribosome binding site; other site 1389489005281 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1389489005282 active site 1389489005283 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1389489005284 adenylate kinase; Reviewed; Region: adk; PRK00279 1389489005285 AMP-binding site [chemical binding]; other site 1389489005286 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1389489005287 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1389489005288 SecY translocase; Region: SecY; pfam00344 1389489005289 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1389489005290 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1389489005291 23S rRNA binding site [nucleotide binding]; other site 1389489005292 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1389489005293 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1389489005294 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1389489005295 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1389489005296 5S rRNA interface [nucleotide binding]; other site 1389489005297 L27 interface [polypeptide binding]; other site 1389489005298 23S rRNA interface [nucleotide binding]; other site 1389489005299 L5 interface [polypeptide binding]; other site 1389489005300 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1389489005301 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1389489005302 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1389489005303 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1389489005304 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1389489005305 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1389489005306 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1389489005307 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1389489005308 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1389489005309 RNA binding site [nucleotide binding]; other site 1389489005310 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1389489005311 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1389489005312 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1389489005313 23S rRNA interface [nucleotide binding]; other site 1389489005314 putative translocon interaction site; other site 1389489005315 signal recognition particle (SRP54) interaction site; other site 1389489005316 L23 interface [polypeptide binding]; other site 1389489005317 trigger factor interaction site; other site 1389489005318 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1389489005319 23S rRNA interface [nucleotide binding]; other site 1389489005320 5S rRNA interface [nucleotide binding]; other site 1389489005321 putative antibiotic binding site [chemical binding]; other site 1389489005322 L25 interface [polypeptide binding]; other site 1389489005323 L27 interface [polypeptide binding]; other site 1389489005324 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1389489005325 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1389489005326 G-X-X-G motif; other site 1389489005327 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1389489005328 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1389489005329 protein-rRNA interface [nucleotide binding]; other site 1389489005330 putative translocon binding site; other site 1389489005331 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1389489005332 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1389489005333 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1389489005334 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1389489005335 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1389489005336 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1389489005337 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1389489005338 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1389489005339 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1389489005340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1389489005341 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489005342 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489005343 Integrase core domain; Region: rve; pfam00665 1389489005344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489005345 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1389489005346 TAP-like protein; Region: Abhydrolase_4; pfam08386 1389489005347 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1389489005348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489005349 Walker A motif; other site 1389489005350 ATP binding site [chemical binding]; other site 1389489005351 Walker B motif; other site 1389489005352 arginine finger; other site 1389489005353 thymidylate kinase; Validated; Region: tmk; PRK00698 1389489005354 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1389489005355 TMP-binding site; other site 1389489005356 ATP-binding site [chemical binding]; other site 1389489005357 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1389489005358 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1389489005359 active site 1389489005360 metal binding site [ion binding]; metal-binding site 1389489005361 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1389489005362 domain I; other site 1389489005363 phosphate binding site [ion binding]; other site 1389489005364 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1389489005365 domain II; other site 1389489005366 domain III; other site 1389489005367 nucleotide binding site [chemical binding]; other site 1389489005368 DNA binding groove [nucleotide binding] 1389489005369 catalytic site [active] 1389489005370 domain IV; other site 1389489005371 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1389489005372 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1389489005373 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1389489005374 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1389489005375 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1389489005376 ATP binding site [chemical binding]; other site 1389489005377 Walker B motif; other site 1389489005378 acetyl-CoA synthetase; Provisional; Region: PRK00174 1389489005379 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1389489005380 active site 1389489005381 CoA binding site [chemical binding]; other site 1389489005382 acyl-activating enzyme (AAE) consensus motif; other site 1389489005383 AMP binding site [chemical binding]; other site 1389489005384 acetate binding site [chemical binding]; other site 1389489005385 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1389489005386 homotrimer interaction site [polypeptide binding]; other site 1389489005387 putative active site [active] 1389489005388 Transglycosylase; Region: Transgly; pfam00912 1389489005389 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1389489005390 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1389489005391 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489005392 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1389489005393 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1389489005394 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1389489005395 active site 1389489005396 metal binding site [ion binding]; metal-binding site 1389489005397 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1389489005398 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 1389489005399 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1389489005400 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1389489005401 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1389489005402 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1389489005403 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1389489005404 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1389489005405 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1389489005406 thymidine kinase; Provisional; Region: PRK04296 1389489005407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489005408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1389489005409 active site 1389489005410 phosphorylation site [posttranslational modification] 1389489005411 intermolecular recognition site; other site 1389489005412 dimerization interface [polypeptide binding]; other site 1389489005413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489005414 DNA binding residues [nucleotide binding] 1389489005415 dimerization interface [polypeptide binding]; other site 1389489005416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1389489005417 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1389489005418 malate:quinone oxidoreductase; Validated; Region: PRK05257 1389489005419 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1389489005420 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1389489005421 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1389489005422 aspartate kinase; Reviewed; Region: PRK06635 1389489005423 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1389489005424 putative nucleotide binding site [chemical binding]; other site 1389489005425 putative catalytic residues [active] 1389489005426 putative Mg ion binding site [ion binding]; other site 1389489005427 putative aspartate binding site [chemical binding]; other site 1389489005428 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1389489005429 putative allosteric regulatory site; other site 1389489005430 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1389489005431 putative allosteric regulatory residue; other site 1389489005432 recombination protein RecR; Reviewed; Region: recR; PRK00076 1389489005433 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1389489005434 RecR protein; Region: RecR; pfam02132 1389489005435 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1389489005436 putative active site [active] 1389489005437 putative metal-binding site [ion binding]; other site 1389489005438 tetramer interface [polypeptide binding]; other site 1389489005439 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1389489005440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489005441 Walker A motif; other site 1389489005442 ATP binding site [chemical binding]; other site 1389489005443 Walker B motif; other site 1389489005444 arginine finger; other site 1389489005445 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1389489005446 RHS Repeat; Region: RHS_repeat; cl11982 1389489005447 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1389489005448 ribonuclease; Region: Ribonuclease; pfam00545 1389489005449 active site 1389489005450 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1389489005451 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1389489005452 propionate/acetate kinase; Provisional; Region: PRK12379 1389489005453 phosphate acetyltransferase; Reviewed; Region: PRK05632 1389489005454 DRTGG domain; Region: DRTGG; pfam07085 1389489005455 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1389489005456 AAA domain; Region: AAA_17; pfam13207 1389489005457 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1389489005458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005459 putative substrate translocation pore; other site 1389489005460 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 1389489005461 xylose isomerase; Provisional; Region: PRK12677 1389489005462 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1389489005463 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1389489005464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489005465 active site 1389489005466 GtrA-like protein; Region: GtrA; pfam04138 1389489005467 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1389489005468 catalytic residues [active] 1389489005469 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1389489005470 cystathionine gamma-synthase; Provisional; Region: PRK07811 1389489005471 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1389489005472 homodimer interface [polypeptide binding]; other site 1389489005473 substrate-cofactor binding pocket; other site 1389489005474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489005475 catalytic residue [active] 1389489005476 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1389489005477 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1389489005478 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1389489005479 FeoA domain; Region: FeoA; pfam04023 1389489005480 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1389489005481 Septum formation; Region: Septum_form; pfam13845 1389489005482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1389489005483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1389489005484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489005485 Walker A/P-loop; other site 1389489005486 ATP binding site [chemical binding]; other site 1389489005487 Q-loop/lid; other site 1389489005488 ABC transporter signature motif; other site 1389489005489 Walker B; other site 1389489005490 D-loop; other site 1389489005491 H-loop/switch region; other site 1389489005492 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1389489005493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489005494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489005495 dimer interface [polypeptide binding]; other site 1389489005496 conserved gate region; other site 1389489005497 putative PBP binding loops; other site 1389489005498 ABC-ATPase subunit interface; other site 1389489005499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1389489005500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1389489005501 DNA binding site [nucleotide binding] 1389489005502 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1389489005503 ligand binding site [chemical binding]; other site 1389489005504 dimerization interface [polypeptide binding]; other site 1389489005505 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1389489005506 NAD(P) binding site [chemical binding]; other site 1389489005507 Integrase core domain; Region: rve; pfam00665 1389489005508 Integrase core domain; Region: rve_3; pfam13683 1389489005509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1389489005511 MarR family; Region: MarR; pfam01047 1389489005512 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1389489005513 core dimer interface [polypeptide binding]; other site 1389489005514 peripheral dimer interface [polypeptide binding]; other site 1389489005515 L10 interface [polypeptide binding]; other site 1389489005516 L11 interface [polypeptide binding]; other site 1389489005517 putative EF-Tu interaction site [polypeptide binding]; other site 1389489005518 putative EF-G interaction site [polypeptide binding]; other site 1389489005519 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1389489005520 23S rRNA interface [nucleotide binding]; other site 1389489005521 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1389489005522 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1389489005523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1389489005524 HAMP domain; Region: HAMP; pfam00672 1389489005525 dimerization interface [polypeptide binding]; other site 1389489005526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1389489005527 dimer interface [polypeptide binding]; other site 1389489005528 phosphorylation site [posttranslational modification] 1389489005529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489005530 ATP binding site [chemical binding]; other site 1389489005531 Mg2+ binding site [ion binding]; other site 1389489005532 G-X-G motif; other site 1389489005533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489005534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489005535 active site 1389489005536 phosphorylation site [posttranslational modification] 1389489005537 intermolecular recognition site; other site 1389489005538 dimerization interface [polypeptide binding]; other site 1389489005539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489005540 DNA binding site [nucleotide binding] 1389489005541 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1389489005542 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1389489005543 FtsX-like permease family; Region: FtsX; pfam02687 1389489005544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1389489005545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1389489005546 Walker A/P-loop; other site 1389489005547 ATP binding site [chemical binding]; other site 1389489005548 Q-loop/lid; other site 1389489005549 ABC transporter signature motif; other site 1389489005550 Walker B; other site 1389489005551 D-loop; other site 1389489005552 H-loop/switch region; other site 1389489005553 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1389489005554 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1389489005555 Integrase core domain; Region: rve; pfam00665 1389489005556 Integrase core domain; Region: rve_3; pfam13683 1389489005557 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1389489005558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489005559 active site 1389489005560 phosphorylation site [posttranslational modification] 1389489005561 intermolecular recognition site; other site 1389489005562 dimerization interface [polypeptide binding]; other site 1389489005563 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1389489005564 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1389489005565 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1389489005566 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005567 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005568 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005569 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005570 Immunoglobulin domain; Region: Ig; cl11960 1389489005571 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1389489005572 Catalytic site [active] 1389489005573 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1389489005574 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005575 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005576 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1389489005577 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1389489005578 active site 1389489005579 catalytic residues [active] 1389489005580 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489005581 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1389489005582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005583 Predicted ATPase [General function prediction only]; Region: COG3903 1389489005584 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1389489005585 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1389489005586 Ligand Binding Site [chemical binding]; other site 1389489005587 Molecular Tunnel; other site 1389489005588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1389489005589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1389489005590 active site 1389489005591 catalytic tetrad [active] 1389489005592 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1389489005593 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1389489005594 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1389489005595 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1389489005596 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1389489005597 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 1389489005598 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1389489005599 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1389489005600 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1389489005601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1389489005602 active site 1389489005603 nucleotide binding site [chemical binding]; other site 1389489005604 HIGH motif; other site 1389489005605 KMSKS motif; other site 1389489005606 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1389489005607 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1389489005608 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1389489005609 Cupin domain; Region: Cupin_2; pfam07883 1389489005610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005611 putative substrate translocation pore; other site 1389489005612 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1389489005613 hypothetical protein; Provisional; Region: PRK07206 1389489005614 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1389489005615 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1389489005616 catalytic loop [active] 1389489005617 iron binding site [ion binding]; other site 1389489005618 acyl-coenzyme A oxidase; Region: PLN02636 1389489005619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1389489005620 active site 1389489005621 Integrase core domain; Region: rve; pfam00665 1389489005622 Integrase core domain; Region: rve_3; pfam13683 1389489005623 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1389489005624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1389489005625 ATP binding site [chemical binding]; other site 1389489005626 putative Mg++ binding site [ion binding]; other site 1389489005627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1389489005628 nucleotide binding region [chemical binding]; other site 1389489005629 ATP-binding site [chemical binding]; other site 1389489005630 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1389489005631 HRDC domain; Region: HRDC; pfam00570 1389489005632 L-asparagine permease; Provisional; Region: PRK15049 1389489005633 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1389489005634 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1389489005635 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1389489005636 Walker A/P-loop; other site 1389489005637 ATP binding site [chemical binding]; other site 1389489005638 Q-loop/lid; other site 1389489005639 ABC transporter signature motif; other site 1389489005640 Walker B; other site 1389489005641 D-loop; other site 1389489005642 H-loop/switch region; other site 1389489005643 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1389489005644 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1389489005645 Walker A/P-loop; other site 1389489005646 ATP binding site [chemical binding]; other site 1389489005647 Q-loop/lid; other site 1389489005648 ABC transporter signature motif; other site 1389489005649 Walker B; other site 1389489005650 D-loop; other site 1389489005651 H-loop/switch region; other site 1389489005652 Cobalt transport protein; Region: CbiQ; cl00463 1389489005653 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1389489005654 MarR family; Region: MarR; pfam01047 1389489005655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1389489005656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1389489005657 DNA binding residues [nucleotide binding] 1389489005658 dimerization interface [polypeptide binding]; other site 1389489005659 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1389489005660 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1389489005661 synthetase active site [active] 1389489005662 NTP binding site [chemical binding]; other site 1389489005663 metal binding site [ion binding]; metal-binding site 1389489005664 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1389489005665 active site 1389489005666 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1389489005667 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1389489005668 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489005669 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1389489005670 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1389489005671 active site 1389489005672 catalytic residues [active] 1389489005673 DNA binding site [nucleotide binding] 1389489005674 Int/Topo IB signature motif; other site 1389489005675 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1389489005676 Phage portal protein; Region: Phage_portal; pfam04860 1389489005677 Phage Terminase; Region: Terminase_1; pfam03354 1389489005678 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1389489005679 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1389489005680 active site 1389489005681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1389489005682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1389489005683 non-specific DNA binding site [nucleotide binding]; other site 1389489005684 salt bridge; other site 1389489005685 sequence-specific DNA binding site [nucleotide binding]; other site 1389489005686 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1389489005687 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1389489005688 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1389489005689 Integrase core domain; Region: rve; pfam00665 1389489005690 Integrase core domain; Region: rve_3; pfam13683 1389489005691 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1389489005692 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1389489005693 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1389489005694 active site 1389489005695 catalytic site [active] 1389489005696 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1389489005697 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1389489005698 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1389489005699 catalytic site [active] 1389489005700 active site 1389489005701 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1389489005702 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1389489005703 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1389489005704 active site 1389489005705 catalytic site [active] 1389489005706 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1389489005707 active site 1389489005708 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1389489005709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489005710 S-adenosylmethionine binding site [chemical binding]; other site 1389489005711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1389489005712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489005713 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1389489005714 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1389489005715 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1389489005716 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1389489005717 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1389489005718 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1389489005719 catalytic residues [active] 1389489005720 catalytic nucleophile [active] 1389489005721 Presynaptic Site I dimer interface [polypeptide binding]; other site 1389489005722 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1389489005723 Synaptic Flat tetramer interface [polypeptide binding]; other site 1389489005724 Synaptic Site I dimer interface [polypeptide binding]; other site 1389489005725 DNA binding site [nucleotide binding] 1389489005726 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1389489005727 DNA-binding interface [nucleotide binding]; DNA binding site 1389489005728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005729 putative substrate translocation pore; other site 1389489005730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1389489005732 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1389489005733 substrate binding site [chemical binding]; other site 1389489005734 ATP binding site [chemical binding]; other site 1389489005735 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1389489005736 intersubunit interface [polypeptide binding]; other site 1389489005737 active site 1389489005738 Zn2+ binding site [ion binding]; other site 1389489005739 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1389489005740 AP (apurinic/apyrimidinic) site pocket; other site 1389489005741 DNA interaction; other site 1389489005742 Metal-binding active site; metal-binding site 1389489005743 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1389489005744 active site 1389489005745 magnesium binding site [ion binding]; other site 1389489005746 dimer interface [polypeptide binding]; other site 1389489005747 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1389489005748 active site 1389489005749 substrate binding pocket [chemical binding]; other site 1389489005750 homodimer interaction site [polypeptide binding]; other site 1389489005751 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1389489005752 H+ Antiporter protein; Region: 2A0121; TIGR00900 1389489005753 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1389489005754 seryl-tRNA synthetase; Provisional; Region: PRK05431 1389489005755 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1389489005756 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1389489005757 dimer interface [polypeptide binding]; other site 1389489005758 active site 1389489005759 motif 1; other site 1389489005760 motif 2; other site 1389489005761 motif 3; other site 1389489005762 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1389489005763 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1389489005764 Prephenate dehydratase; Region: PDT; pfam00800 1389489005765 prephenate dehydratase; Provisional; Region: PRK11898 1389489005766 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1389489005767 putative L-Phe binding site [chemical binding]; other site 1389489005768 phosphoglucomutase; Validated; Region: PRK07564 1389489005769 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1389489005770 active site 1389489005771 substrate binding site [chemical binding]; other site 1389489005772 metal binding site [ion binding]; metal-binding site 1389489005773 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1389489005774 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1389489005775 Putative amidase domain; Region: Amidase_6; pfam12671 1389489005776 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1389489005777 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1389489005778 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1389489005779 active site 1389489005780 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1389489005781 DNA methylase; Region: N6_N4_Mtase; pfam01555 1389489005782 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1389489005783 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1389489005784 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1389489005785 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1389489005786 MarR family; Region: MarR; pfam01047 1389489005787 H+ Antiporter protein; Region: 2A0121; TIGR00900 1389489005788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005789 RHS Repeat; Region: RHS_repeat; cl11982 1389489005790 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1389489005791 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1389489005792 catalytic residues [active] 1389489005793 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1389489005794 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1389489005795 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1389489005796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489005797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489005798 dimer interface [polypeptide binding]; other site 1389489005799 conserved gate region; other site 1389489005800 putative PBP binding loops; other site 1389489005801 ABC-ATPase subunit interface; other site 1389489005802 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1389489005803 POT family; Region: PTR2; cl17359 1389489005804 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1389489005805 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1389489005806 putative DNA binding site [nucleotide binding]; other site 1389489005807 putative Zn2+ binding site [ion binding]; other site 1389489005808 AsnC family; Region: AsnC_trans_reg; pfam01037 1389489005809 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1389489005810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1389489005811 active site 1389489005812 phosphorylation site [posttranslational modification] 1389489005813 intermolecular recognition site; other site 1389489005814 dimerization interface [polypeptide binding]; other site 1389489005815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1389489005816 DNA binding site [nucleotide binding] 1389489005817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1389489005818 HAMP domain; Region: HAMP; pfam00672 1389489005819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1389489005820 dimer interface [polypeptide binding]; other site 1389489005821 phosphorylation site [posttranslational modification] 1389489005822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1389489005823 Mg2+ binding site [ion binding]; other site 1389489005824 G-X-G motif; other site 1389489005825 Proline dehydrogenase; Region: Pro_dh; cl03282 1389489005826 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1389489005827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1389489005828 NAD(P) binding site [chemical binding]; other site 1389489005829 catalytic residues [active] 1389489005830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1389489005831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1389489005832 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1389489005833 putative dimerization interface [polypeptide binding]; other site 1389489005834 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1389489005835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1389489005836 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1389489005837 hydrophobic ligand binding site; other site 1389489005838 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1389489005839 synthetase active site [active] 1389489005840 NTP binding site [chemical binding]; other site 1389489005841 metal binding site [ion binding]; metal-binding site 1389489005842 Protein of unknown function (DUF2746); Region: DUF2746; pfam10874 1389489005843 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1389489005844 active site 1389489005845 Phage tail protein; Region: Sipho_tail; cl17486 1389489005846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1389489005847 Helix-turn-helix domain; Region: HTH_19; pfam12844 1389489005848 sequence-specific DNA binding site [nucleotide binding]; other site 1389489005849 salt bridge; other site 1389489005850 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1389489005851 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1389489005852 Int/Topo IB signature motif; other site 1389489005853 DNA binding site [nucleotide binding] 1389489005854 active site 1389489005855 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1389489005856 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1389489005857 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1389489005858 dimer interface [polypeptide binding]; other site 1389489005859 tetramer interface [polypeptide binding]; other site 1389489005860 PYR/PP interface [polypeptide binding]; other site 1389489005861 TPP binding site [chemical binding]; other site 1389489005862 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1389489005863 TPP-binding site [chemical binding]; other site 1389489005864 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1389489005865 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1389489005866 UbiA prenyltransferase family; Region: UbiA; pfam01040 1389489005867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1389489005868 acyl-activating enzyme (AAE) consensus motif; other site 1389489005869 AMP binding site [chemical binding]; other site 1389489005870 active site 1389489005871 CoA binding site [chemical binding]; other site 1389489005872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1389489005873 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1389489005874 substrate binding site [chemical binding]; other site 1389489005875 oxyanion hole (OAH) forming residues; other site 1389489005876 trimer interface [polypeptide binding]; other site 1389489005877 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1389489005878 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1389489005879 active site 1389489005880 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1389489005881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489005882 active site 1389489005883 motif I; other site 1389489005884 motif II; other site 1389489005885 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1389489005886 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1389489005887 ResB-like family; Region: ResB; pfam05140 1389489005888 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1389489005889 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1389489005890 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1389489005891 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1389489005892 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1389489005893 catalytic residues [active] 1389489005894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1389489005895 catalytic core [active] 1389489005896 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1389489005897 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 1389489005898 Dimer interface [polypeptide binding]; other site 1389489005899 anticodon binding site; other site 1389489005900 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1389489005901 motif 1; other site 1389489005902 dimer interface [polypeptide binding]; other site 1389489005903 active site 1389489005904 motif 2; other site 1389489005905 motif 3; other site 1389489005906 hypothetical protein; Reviewed; Region: PRK00024 1389489005907 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1389489005908 MPN+ (JAMM) motif; other site 1389489005909 Zinc-binding site [ion binding]; other site 1389489005910 Integrase core domain; Region: rve; pfam00665 1389489005911 Integrase core domain; Region: rve_3; pfam13683 1389489005912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489005913 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1389489005914 Walker A motif; other site 1389489005915 ATP binding site [chemical binding]; other site 1389489005916 Walker B motif; other site 1389489005917 arginine finger; other site 1389489005918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1389489005919 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1389489005920 Walker A motif; other site 1389489005921 ATP binding site [chemical binding]; other site 1389489005922 Walker B motif; other site 1389489005923 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1389489005924 putative proline-specific permease; Provisional; Region: proY; PRK10580 1389489005925 Spore germination protein; Region: Spore_permease; cl17796 1389489005926 Copper resistance protein D; Region: CopD; pfam05425 1389489005927 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1389489005928 CopC domain; Region: CopC; pfam04234 1389489005929 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1389489005930 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1389489005931 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1389489005932 DNA binding site [nucleotide binding] 1389489005933 active site 1389489005934 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1389489005935 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1389489005936 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1389489005937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1389489005938 S-adenosylmethionine binding site [chemical binding]; other site 1389489005939 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1389489005940 Catalytic site [active] 1389489005941 Putative esterase; Region: Esterase; pfam00756 1389489005942 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1389489005943 DNA binding residues [nucleotide binding] 1389489005944 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1389489005945 putative dimer interface [polypeptide binding]; other site 1389489005946 chaperone protein DnaJ; Provisional; Region: PRK14279 1389489005947 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1389489005948 HSP70 interaction site [polypeptide binding]; other site 1389489005949 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1389489005950 substrate binding site [polypeptide binding]; other site 1389489005951 dimer interface [polypeptide binding]; other site 1389489005952 GrpE; Region: GrpE; pfam01025 1389489005953 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1389489005954 dimer interface [polypeptide binding]; other site 1389489005955 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1389489005956 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1389489005957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1389489005958 nucleotide binding site [chemical binding]; other site 1389489005959 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1389489005960 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1389489005961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489005962 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1389489005963 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1389489005964 active site 1389489005965 metal binding site [ion binding]; metal-binding site 1389489005966 nudix motif; other site 1389489005967 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489005968 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489005969 Integrase core domain; Region: rve; pfam00665 1389489005970 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1389489005971 trimer interface [polypeptide binding]; other site 1389489005972 active site 1389489005973 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1389489005974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489005975 DNA-binding site [nucleotide binding]; DNA binding site 1389489005976 UTRA domain; Region: UTRA; pfam07702 1389489005977 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1389489005978 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1389489005979 ATP binding site [chemical binding]; other site 1389489005980 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1389489005981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1389489005982 DNA-binding site [nucleotide binding]; DNA binding site 1389489005983 RNA-binding motif; other site 1389489005984 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1389489005985 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1389489005986 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1389489005987 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1389489005988 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1389489005989 TrkA-C domain; Region: TrkA_C; pfam02080 1389489005990 META domain; Region: META; pfam03724 1389489005991 MMPL family; Region: MMPL; pfam03176 1389489005992 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489005993 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489005994 Integrase core domain; Region: rve; pfam00665 1389489005995 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1389489005996 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1389489005997 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1389489005998 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1389489005999 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1389489006000 ATP binding site [chemical binding]; other site 1389489006001 active site 1389489006002 substrate binding site [chemical binding]; other site 1389489006003 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1389489006004 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1389489006005 putative metal binding site [ion binding]; other site 1389489006006 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1389489006007 active site 1389489006008 Helix-turn-helix domain; Region: HTH_38; pfam13936 1389489006009 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1389489006010 Integrase core domain; Region: rve; pfam00665 1389489006011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489006012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1389489006013 putative substrate translocation pore; other site 1389489006014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1389489006015 Predicted transcriptional regulators [Transcription]; Region: COG1695 1389489006016 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1389489006017 Predicted transcriptional regulator [Transcription]; Region: COG2345 1389489006018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489006019 motif II; other site 1389489006020 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1389489006021 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1389489006022 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1389489006023 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1389489006024 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1389489006025 putative active site [active] 1389489006026 catalytic triad [active] 1389489006027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1389489006028 Integrase core domain; Region: rve; pfam00665 1389489006029 Integrase core domain; Region: rve_3; pfam13683 1389489006030 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1389489006031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1389489006032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1389489006033 active site 1389489006034 catalytic tetrad [active] 1389489006035 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1389489006036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1389489006037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1389489006038 dimerization interface [polypeptide binding]; other site 1389489006039 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1389489006040 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1389489006041 gating phenylalanine in ion channel; other site 1389489006042 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1389489006043 Beta-lactamase; Region: Beta-lactamase; pfam00144 1389489006044 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1389489006045 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1389489006046 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1389489006047 heme binding pocket [chemical binding]; other site 1389489006048 heme ligand [chemical binding]; other site 1389489006049 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1389489006050 phosphopeptide binding site; other site 1389489006051 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1389489006052 Protein of unknown function DUF58; Region: DUF58; pfam01882 1389489006053 MoxR-like ATPases [General function prediction only]; Region: COG0714 1389489006054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1389489006055 Walker A motif; other site 1389489006056 ATP binding site [chemical binding]; other site 1389489006057 arginine finger; other site 1389489006058 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1389489006059 Interdomain contacts; other site 1389489006060 Cytokine receptor motif; other site 1389489006061 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1389489006062 Interdomain contacts; other site 1389489006063 Cytokine receptor motif; other site 1389489006064 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1389489006065 activation loop (A-loop); other site 1389489006066 AAA domain; Region: AAA_30; pfam13604 1389489006067 PIF1-like helicase; Region: PIF1; pfam05970 1389489006068 Family description; Region: UvrD_C_2; pfam13538 1389489006069 Copper resistance protein D; Region: CopD; cl00563 1389489006070 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1389489006071 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1389489006072 IHF dimer interface [polypeptide binding]; other site 1389489006073 IHF - DNA interface [nucleotide binding]; other site 1389489006074 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1389489006075 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1389489006076 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1389489006077 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1389489006078 metal binding site 2 [ion binding]; metal-binding site 1389489006079 putative DNA binding helix; other site 1389489006080 metal binding site 1 [ion binding]; metal-binding site 1389489006081 dimer interface [polypeptide binding]; other site 1389489006082 structural Zn2+ binding site [ion binding]; other site 1389489006083 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1389489006084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1389489006085 putative PBP binding regions; other site 1389489006086 ABC-ATPase subunit interface; other site 1389489006087 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1389489006088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1389489006089 Walker A/P-loop; other site 1389489006090 ATP binding site [chemical binding]; other site 1389489006091 Q-loop/lid; other site 1389489006092 ABC transporter signature motif; other site 1389489006093 Walker B; other site 1389489006094 D-loop; other site 1389489006095 H-loop/switch region; other site 1389489006096 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1389489006097 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1389489006098 intersubunit interface [polypeptide binding]; other site 1389489006099 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1389489006100 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1389489006101 E3 interaction surface; other site 1389489006102 lipoyl attachment site [posttranslational modification]; other site 1389489006103 e3 binding domain; Region: E3_binding; pfam02817 1389489006104 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1389489006105 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1389489006106 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1389489006107 alpha subunit interface [polypeptide binding]; other site 1389489006108 TPP binding site [chemical binding]; other site 1389489006109 heterodimer interface [polypeptide binding]; other site 1389489006110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1389489006111 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1389489006112 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1389489006113 TPP-binding site [chemical binding]; other site 1389489006114 tetramer interface [polypeptide binding]; other site 1389489006115 heterodimer interface [polypeptide binding]; other site 1389489006116 phosphorylation loop region [posttranslational modification] 1389489006117 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1389489006118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489006119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489006120 homodimer interface [polypeptide binding]; other site 1389489006121 catalytic residue [active] 1389489006122 Membrane protein of unknown function; Region: DUF360; pfam04020 1389489006123 adenylosuccinate lyase; Provisional; Region: PRK09285 1389489006124 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1389489006125 tetramer interface [polypeptide binding]; other site 1389489006126 active site 1389489006127 Integrase core domain; Region: rve; pfam00665 1389489006128 Integrase core domain; Region: rve_3; pfam13683 1389489006129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1389489006130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1389489006131 Coenzyme A binding pocket [chemical binding]; other site 1389489006132 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1389489006133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489006134 DNA-binding site [nucleotide binding]; DNA binding site 1389489006135 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1389489006136 putative FMN binding site [chemical binding]; other site 1389489006137 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1389489006138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1389489006139 active site 1389489006140 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1389489006141 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1389489006142 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1389489006143 DNA binding site [nucleotide binding] 1389489006144 domain linker motif; other site 1389489006145 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1389489006146 ligand binding site [chemical binding]; other site 1389489006147 dimerization interface [polypeptide binding]; other site 1389489006148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1389489006149 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1389489006150 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1389489006151 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1389489006152 tetramer interface [polypeptide binding]; other site 1389489006153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489006154 catalytic residue [active] 1389489006155 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1389489006156 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1389489006157 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1389489006158 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1389489006159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489006160 active site 1389489006161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489006162 NAD(P) binding site [chemical binding]; other site 1389489006163 active site 1389489006164 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1389489006165 putative catalytic site [active] 1389489006166 putative phosphate binding site [ion binding]; other site 1389489006167 active site 1389489006168 metal binding site A [ion binding]; metal-binding site 1389489006169 DNA binding site [nucleotide binding] 1389489006170 putative AP binding site [nucleotide binding]; other site 1389489006171 putative metal binding site B [ion binding]; other site 1389489006172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1389489006173 active site 1389489006174 Septum formation; Region: Septum_form; pfam13845 1389489006175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489006176 UMP phosphatase; Provisional; Region: PRK10444 1389489006177 active site 1389489006178 motif I; other site 1389489006179 motif II; other site 1389489006180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1389489006181 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1389489006182 Predicted membrane protein [Function unknown]; Region: COG1511 1389489006183 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1389489006184 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1389489006185 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1389489006186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1389489006187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1389489006188 Integrase core domain; Region: rve; pfam00665 1389489006189 Integrase core domain; Region: rve_3; pfam13683 1389489006190 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1389489006191 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1389489006192 GDP-binding site [chemical binding]; other site 1389489006193 ACT binding site; other site 1389489006194 IMP binding site; other site 1389489006195 hypothetical protein; Provisional; Region: PRK01346 1389489006196 chorismate mutase; Provisional; Region: PRK09239 1389489006197 short chain dehydrogenase; Provisional; Region: PRK06197 1389489006198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1389489006199 NAD(P) binding site [chemical binding]; other site 1389489006200 active site 1389489006201 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1389489006202 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1389489006203 DXD motif; other site 1389489006204 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1389489006205 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1389489006206 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1389489006207 Transglycosylase; Region: Transgly; pfam00912 1389489006208 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1389489006209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1389489006210 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1389489006211 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1389489006212 dimerization interface [polypeptide binding]; other site 1389489006213 ATP binding site [chemical binding]; other site 1389489006214 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1389489006215 dimerization interface [polypeptide binding]; other site 1389489006216 ATP binding site [chemical binding]; other site 1389489006217 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1389489006218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489006219 Walker A/P-loop; other site 1389489006220 ATP binding site [chemical binding]; other site 1389489006221 Q-loop/lid; other site 1389489006222 ABC transporter signature motif; other site 1389489006223 Walker B; other site 1389489006224 D-loop; other site 1389489006225 H-loop/switch region; other site 1389489006226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1389489006227 Walker A/P-loop; other site 1389489006228 ATP binding site [chemical binding]; other site 1389489006229 Q-loop/lid; other site 1389489006230 ABC transporter signature motif; other site 1389489006231 Walker B; other site 1389489006232 D-loop; other site 1389489006233 H-loop/switch region; other site 1389489006234 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1389489006235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1389489006236 rhodanese superfamily protein; Provisional; Region: PRK05320 1389489006237 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1389489006238 active site residue [active] 1389489006239 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1389489006240 Ligand binding site; other site 1389489006241 Putative Catalytic site; other site 1389489006242 DXD motif; other site 1389489006243 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1389489006244 substrate binding site [chemical binding]; other site 1389489006245 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1389489006246 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1389489006247 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1389489006248 tetramer interface [polypeptide binding]; other site 1389489006249 active site 1389489006250 Mg2+/Mn2+ binding site [ion binding]; other site 1389489006251 citrate synthase; Provisional; Region: PRK14033 1389489006252 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1389489006253 oxalacetate binding site [chemical binding]; other site 1389489006254 citrylCoA binding site [chemical binding]; other site 1389489006255 coenzyme A binding site [chemical binding]; other site 1389489006256 catalytic triad [active] 1389489006257 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1389489006258 Integrase core domain; Region: rve; pfam00665 1389489006259 Integrase core domain; Region: rve_3; pfam13683 1389489006260 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1389489006261 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1389489006262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489006263 dimer interface [polypeptide binding]; other site 1389489006264 conserved gate region; other site 1389489006265 putative PBP binding loops; other site 1389489006266 ABC-ATPase subunit interface; other site 1389489006267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1389489006268 dimer interface [polypeptide binding]; other site 1389489006269 conserved gate region; other site 1389489006270 putative PBP binding loops; other site 1389489006271 ABC-ATPase subunit interface; other site 1389489006272 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1389489006273 phosphate binding site [ion binding]; other site 1389489006274 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1389489006275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1389489006276 DNA-binding site [nucleotide binding]; DNA binding site 1389489006277 UTRA domain; Region: UTRA; pfam07702 1389489006278 replicative DNA helicase; Region: DnaB; TIGR00665 1389489006279 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1389489006280 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1389489006281 Walker A motif; other site 1389489006282 ATP binding site [chemical binding]; other site 1389489006283 Walker B motif; other site 1389489006284 DNA binding loops [nucleotide binding] 1389489006285 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1389489006286 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1389489006287 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1389489006288 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1389489006289 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1389489006290 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1389489006291 dimer interface [polypeptide binding]; other site 1389489006292 ssDNA binding site [nucleotide binding]; other site 1389489006293 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1389489006294 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1389489006295 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1389489006296 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1389489006297 active site 1389489006298 NTP binding site [chemical binding]; other site 1389489006299 metal binding triad [ion binding]; metal-binding site 1389489006300 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1389489006301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1389489006302 Zn2+ binding site [ion binding]; other site 1389489006303 Mg2+ binding site [ion binding]; other site 1389489006304 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1389489006305 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1389489006306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1389489006307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1389489006308 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1389489006309 catalytic residues [active] 1389489006310 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1389489006311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1389489006312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1389489006313 homodimer interface [polypeptide binding]; other site 1389489006314 catalytic residue [active] 1389489006315 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1389489006316 ParB-like nuclease domain; Region: ParB; smart00470 1389489006317 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1389489006318 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1389489006319 Magnesium ion binding site [ion binding]; other site 1389489006320 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1389489006321 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1389489006322 G-X-X-G motif; other site 1389489006323 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1389489006324 RxxxH motif; other site 1389489006325 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1389489006326 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1389489006327 hypothetical protein; Provisional; Region: PRK14378 1389489006328 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1389489006329 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399