-- dump date 20140619_130908 -- class Genbank::misc_feature -- table misc_feature_note -- id note 111781000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 111781000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 111781000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781000004 Walker A motif; other site 111781000005 ATP binding site [chemical binding]; other site 111781000006 Walker B motif; other site 111781000007 arginine finger; other site 111781000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 111781000009 DnaA box-binding interface [nucleotide binding]; other site 111781000010 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 111781000011 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 111781000012 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 111781000013 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 111781000014 active site 111781000015 homodimer interface [polypeptide binding]; other site 111781000016 Caspase domain; Region: Peptidase_C14; pfam00656 111781000017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781000018 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 111781000019 dimer interface [polypeptide binding]; other site 111781000020 allosteric magnesium binding site [ion binding]; other site 111781000021 active site 111781000022 aspartate-rich active site metal binding site; other site 111781000023 Schiff base residues; other site 111781000024 TPR repeat; Region: TPR_11; pfam13414 111781000025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000026 binding surface 111781000027 TPR motif; other site 111781000028 TPR repeat; Region: TPR_11; pfam13414 111781000029 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 111781000030 Uncharacterized conserved protein [Function unknown]; Region: COG2361 111781000031 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781000032 active site 111781000033 NTP binding site [chemical binding]; other site 111781000034 metal binding triad [ion binding]; metal-binding site 111781000035 antibiotic binding site [chemical binding]; other site 111781000036 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781000037 putative active site [active] 111781000038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781000039 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781000040 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781000041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781000042 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 111781000043 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 111781000044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781000045 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 111781000046 Coenzyme A binding pocket [chemical binding]; other site 111781000047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781000048 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781000049 active site 111781000050 ATP binding site [chemical binding]; other site 111781000051 substrate binding site [chemical binding]; other site 111781000052 activation loop (A-loop); other site 111781000053 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 111781000054 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 111781000055 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 111781000056 metal ion-dependent adhesion site (MIDAS); other site 111781000057 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 111781000058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781000059 Coenzyme A binding pocket [chemical binding]; other site 111781000060 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 111781000061 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 111781000062 Walker A/P-loop; other site 111781000063 ATP binding site [chemical binding]; other site 111781000064 Q-loop/lid; other site 111781000065 ABC transporter signature motif; other site 111781000066 Walker B; other site 111781000067 D-loop; other site 111781000068 H-loop/switch region; other site 111781000069 AAA domain; Region: AAA_26; pfam13500 111781000070 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 111781000071 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 111781000072 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 111781000073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781000074 active site 111781000075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781000076 Coenzyme A binding pocket [chemical binding]; other site 111781000077 Fatty acid desaturase; Region: FA_desaturase; pfam00487 111781000078 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 111781000079 putative di-iron ligands [ion binding]; other site 111781000080 Predicted membrane protein [Function unknown]; Region: COG2119 111781000081 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 111781000082 Predicted membrane protein [Function unknown]; Region: COG2119 111781000083 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 111781000084 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 111781000085 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 111781000086 dimer interface [polypeptide binding]; other site 111781000087 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 111781000088 active site 111781000089 Fe binding site [ion binding]; other site 111781000090 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 111781000091 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 111781000092 Ligand binding site; other site 111781000093 Putative Catalytic site; other site 111781000094 DXD motif; other site 111781000095 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 111781000096 NlpC/P60 family; Region: NLPC_P60; pfam00877 111781000097 ABC-2 type transporter; Region: ABC2_membrane; cl17235 111781000098 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 111781000099 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 111781000100 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 111781000101 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 111781000102 TIR domain; Region: TIR_2; pfam13676 111781000103 TIR domain; Region: TIR_2; pfam13676 111781000104 TIR domain; Region: TIR_2; pfam13676 111781000105 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781000106 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781000107 structural tetrad; other site 111781000108 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781000109 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781000110 structural tetrad; other site 111781000111 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 111781000112 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 111781000113 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 111781000114 metal binding site [ion binding]; metal-binding site 111781000115 dimer interface [polypeptide binding]; other site 111781000116 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781000117 putative active site [active] 111781000118 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 111781000119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 111781000120 magnesium chelatase subunit H; Provisional; Region: PRK12493 111781000121 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 111781000122 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 111781000123 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 111781000124 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 111781000125 dihydropteroate synthase; Region: DHPS; TIGR01496 111781000126 substrate binding pocket [chemical binding]; other site 111781000127 dimer interface [polypeptide binding]; other site 111781000128 inhibitor binding site; inhibition site 111781000129 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 111781000130 putative catalytic site [active] 111781000131 putative phosphate binding site [ion binding]; other site 111781000132 active site 111781000133 metal binding site A [ion binding]; metal-binding site 111781000134 DNA binding site [nucleotide binding] 111781000135 putative AP binding site [nucleotide binding]; other site 111781000136 putative metal binding site B [ion binding]; other site 111781000137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781000138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781000139 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781000140 iron-sulfur cluster [ion binding]; other site 111781000141 [2Fe-2S] cluster binding site [ion binding]; other site 111781000142 Cache domain; Region: Cache_1; pfam02743 111781000143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781000144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781000145 dimerization interface [polypeptide binding]; other site 111781000146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781000147 dimer interface [polypeptide binding]; other site 111781000148 phosphorylation site [posttranslational modification] 111781000149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781000150 ATP binding site [chemical binding]; other site 111781000151 Mg2+ binding site [ion binding]; other site 111781000152 G-X-G motif; other site 111781000153 Response regulator receiver domain; Region: Response_reg; pfam00072 111781000154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781000155 active site 111781000156 phosphorylation site [posttranslational modification] 111781000157 intermolecular recognition site; other site 111781000158 dimerization interface [polypeptide binding]; other site 111781000159 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781000160 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781000161 TMAO/DMSO reductase; Reviewed; Region: PRK05363 111781000162 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 111781000163 Moco binding site; other site 111781000164 metal coordination site [ion binding]; other site 111781000165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781000166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 111781000167 putative substrate translocation pore; other site 111781000168 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781000169 putative active site [active] 111781000170 ornithine carbamoyltransferase; Provisional; Region: PRK00779 111781000171 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 111781000172 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 111781000173 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 111781000174 prephenate dehydrogenase; Validated; Region: PRK08507 111781000175 arogenate dehydrogenase; Reviewed; Region: PRK07417 111781000176 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 111781000177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781000178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781000179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781000180 Walker A/P-loop; other site 111781000181 ATP binding site [chemical binding]; other site 111781000182 Q-loop/lid; other site 111781000183 ABC transporter signature motif; other site 111781000184 Walker B; other site 111781000185 D-loop; other site 111781000186 H-loop/switch region; other site 111781000187 pseudaminic acid synthase; Region: PseI; TIGR03586 111781000188 NeuB family; Region: NeuB; pfam03102 111781000189 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 111781000190 NeuB binding interface [polypeptide binding]; other site 111781000191 putative substrate binding site [chemical binding]; other site 111781000192 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 111781000193 putative trimer interface [polypeptide binding]; other site 111781000194 putative CoA binding site [chemical binding]; other site 111781000195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781000196 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781000197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781000198 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781000199 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781000200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781000201 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781000202 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781000203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781000204 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 111781000205 DNA binding residues [nucleotide binding] 111781000206 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 111781000207 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 111781000208 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 111781000209 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 111781000210 ligand binding site; other site 111781000211 tetramer interface; other site 111781000212 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 111781000213 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 111781000214 inhibitor-cofactor binding pocket; inhibition site 111781000215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781000216 catalytic residue [active] 111781000217 Methyltransferase domain; Region: Methyltransf_11; pfam08241 111781000218 Trm112p-like protein; Region: Trm112p; cl01066 111781000219 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 111781000220 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 111781000221 NAD(P) binding site [chemical binding]; other site 111781000222 homodimer interface [polypeptide binding]; other site 111781000223 substrate binding site [chemical binding]; other site 111781000224 active site 111781000225 Repair protein; Region: Repair_PSII; pfam04536 111781000226 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 111781000227 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 111781000228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 111781000229 catalytic core [active] 111781000230 citrate synthase; Provisional; Region: PRK14036 111781000231 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 111781000232 dimer interface [polypeptide binding]; other site 111781000233 active site 111781000234 citrylCoA binding site [chemical binding]; other site 111781000235 oxalacetate/citrate binding site [chemical binding]; other site 111781000236 coenzyme A binding site [chemical binding]; other site 111781000237 catalytic triad [active] 111781000238 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 111781000239 ATP-NAD kinase; Region: NAD_kinase; pfam01513 111781000240 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 111781000241 hypothetical protein; Provisional; Region: PRK02509 111781000242 Uncharacterized conserved protein [Function unknown]; Region: COG1615 111781000243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 111781000244 motif II; other site 111781000245 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 111781000246 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 111781000247 hinge; other site 111781000248 active site 111781000249 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 111781000250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 111781000251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781000252 S-adenosylmethionine binding site [chemical binding]; other site 111781000253 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781000254 Photosystem II protein; Region: PSII; cl08223 111781000255 Photosystem II protein; Region: PSII; cl08223 111781000256 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 111781000257 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 111781000258 Photosystem II protein; Region: PSII; cl08223 111781000259 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 111781000260 protein I interface; other site 111781000261 D2 interface; other site 111781000262 protein T interface; other site 111781000263 chlorophyll binding site; other site 111781000264 beta carotene binding site; other site 111781000265 pheophytin binding site; other site 111781000266 manganese-stabilizing polypeptide interface; other site 111781000267 CP43 interface; other site 111781000268 protein L interface; other site 111781000269 oxygen evolving complex binding site; other site 111781000270 bromide binding site; other site 111781000271 quinone binding site; other site 111781000272 Fe binding site [ion binding]; other site 111781000273 core light harvesting interface; other site 111781000274 cytochrome b559 alpha subunit interface; other site 111781000275 cytochrome c-550 interface; other site 111781000276 protein J interface; other site 111781000277 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781000278 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781000279 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781000280 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781000281 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781000282 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781000283 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781000284 CHAT domain; Region: CHAT; cl17868 111781000285 CHAT domain; Region: CHAT; cl17868 111781000286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781000287 Homeodomain-like domain; Region: HTH_32; pfam13565 111781000288 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781000289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781000290 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 111781000291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781000292 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781000293 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 111781000294 active site 111781000295 catalytic triad [active] 111781000296 oxyanion hole [active] 111781000297 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 111781000298 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 111781000299 acyl-activating enzyme (AAE) consensus motif; other site 111781000300 putative AMP binding site [chemical binding]; other site 111781000301 putative active site [active] 111781000302 putative CoA binding site [chemical binding]; other site 111781000303 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 111781000304 active site 111781000305 metal binding site [ion binding]; metal-binding site 111781000306 Conserved TM helix; Region: TM_helix; pfam05552 111781000307 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781000308 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 111781000309 Response regulator receiver domain; Region: Response_reg; pfam00072 111781000310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781000311 active site 111781000312 phosphorylation site [posttranslational modification] 111781000313 intermolecular recognition site; other site 111781000314 dimerization interface [polypeptide binding]; other site 111781000315 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 111781000316 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 111781000317 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 111781000318 Walker A motif; other site 111781000319 ATP binding site [chemical binding]; other site 111781000320 Walker B motif; other site 111781000321 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 111781000322 Domain of unknown function DUF21; Region: DUF21; pfam01595 111781000323 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 111781000324 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 111781000325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781000326 active site 111781000327 hypothetical protein; Validated; Region: PRK00153 111781000328 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 111781000329 FAD binding domain; Region: FAD_binding_4; pfam01565 111781000330 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 111781000331 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 111781000332 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 111781000333 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781000334 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 111781000335 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 111781000336 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 111781000337 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 111781000338 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 111781000339 Domain of unknown function (DUF814); Region: DUF814; pfam05670 111781000340 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 111781000341 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 111781000342 G1 box; other site 111781000343 GTP/Mg2+ binding site [chemical binding]; other site 111781000344 Switch I region; other site 111781000345 G2 box; other site 111781000346 Switch II region; other site 111781000347 G3 box; other site 111781000348 G4 box; other site 111781000349 G5 box; other site 111781000350 Domain of unknown function (DUF697); Region: DUF697; pfam05128 111781000351 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 111781000352 Protein of unknown function (DUF565); Region: DUF565; pfam04483 111781000353 Clp protease ATP binding subunit; Region: clpC; CHL00095 111781000354 Clp amino terminal domain; Region: Clp_N; pfam02861 111781000355 Clp amino terminal domain; Region: Clp_N; pfam02861 111781000356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781000357 Walker A motif; other site 111781000358 ATP binding site [chemical binding]; other site 111781000359 Walker B motif; other site 111781000360 arginine finger; other site 111781000361 UvrB/uvrC motif; Region: UVR; pfam02151 111781000362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781000363 Walker A motif; other site 111781000364 ATP binding site [chemical binding]; other site 111781000365 Walker B motif; other site 111781000366 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 111781000367 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 111781000368 Protein kinase domain; Region: Pkinase; pfam00069 111781000369 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781000370 active site 111781000371 ATP binding site [chemical binding]; other site 111781000372 substrate binding site [chemical binding]; other site 111781000373 activation loop (A-loop); other site 111781000374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781000375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781000376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781000377 Walker A/P-loop; other site 111781000378 ATP binding site [chemical binding]; other site 111781000379 Q-loop/lid; other site 111781000380 ABC transporter signature motif; other site 111781000381 Walker B; other site 111781000382 D-loop; other site 111781000383 H-loop/switch region; other site 111781000384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 111781000385 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 111781000386 catalytic residues [active] 111781000387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 111781000388 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 111781000389 NAD(P) binding site [chemical binding]; other site 111781000390 homotetramer interface [polypeptide binding]; other site 111781000391 homodimer interface [polypeptide binding]; other site 111781000392 active site 111781000393 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 111781000394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781000395 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 111781000396 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 111781000397 DNA binding residues [nucleotide binding] 111781000398 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 111781000399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781000400 FeS/SAM binding site; other site 111781000401 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 111781000402 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781000404 S-adenosylmethionine binding site [chemical binding]; other site 111781000405 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 111781000406 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 111781000407 catalytic motif [active] 111781000408 Zn binding site [ion binding]; other site 111781000409 RibD C-terminal domain; Region: RibD_C; cl17279 111781000410 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781000411 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 111781000412 putative catalytic residue [active] 111781000413 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781000414 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781000415 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 111781000416 TPR repeat; Region: TPR_11; pfam13414 111781000417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000418 binding surface 111781000419 TPR motif; other site 111781000420 TPR repeat; Region: TPR_11; pfam13414 111781000421 TPR repeat; Region: TPR_11; pfam13414 111781000422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000423 binding surface 111781000424 TPR motif; other site 111781000425 TPR repeat; Region: TPR_11; pfam13414 111781000426 TPR repeat; Region: TPR_11; pfam13414 111781000427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000428 binding surface 111781000429 TPR motif; other site 111781000430 TPR repeat; Region: TPR_11; pfam13414 111781000431 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 111781000432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781000433 TPR repeat; Region: TPR_11; pfam13414 111781000434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000435 binding surface 111781000436 TPR motif; other site 111781000437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781000438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000439 binding surface 111781000440 TPR motif; other site 111781000441 TPR repeat; Region: TPR_11; pfam13414 111781000442 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 111781000443 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781000444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000445 binding surface 111781000446 TPR motif; other site 111781000447 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781000448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000449 binding surface 111781000450 TPR motif; other site 111781000451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000452 binding surface 111781000453 TPR motif; other site 111781000454 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781000455 TPR repeat; Region: TPR_11; pfam13414 111781000456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000457 binding surface 111781000458 TPR motif; other site 111781000459 TPR repeat; Region: TPR_11; pfam13414 111781000460 TPR repeat; Region: TPR_11; pfam13414 111781000461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000462 binding surface 111781000463 TPR motif; other site 111781000464 TPR repeat; Region: TPR_11; pfam13414 111781000465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000466 binding surface 111781000467 TPR motif; other site 111781000468 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781000469 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 111781000470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781000471 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 111781000472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 111781000473 putative DNA binding site [nucleotide binding]; other site 111781000474 putative Zn2+ binding site [ion binding]; other site 111781000475 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 111781000476 putative ABC transporter; Region: ycf24; CHL00085 111781000477 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 111781000478 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 111781000479 Walker A/P-loop; other site 111781000480 ATP binding site [chemical binding]; other site 111781000481 Q-loop/lid; other site 111781000482 ABC transporter signature motif; other site 111781000483 Walker B; other site 111781000484 D-loop; other site 111781000485 H-loop/switch region; other site 111781000486 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 111781000487 FeS assembly protein SufD; Region: sufD; TIGR01981 111781000488 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 111781000489 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 111781000490 E-class dimer interface [polypeptide binding]; other site 111781000491 P-class dimer interface [polypeptide binding]; other site 111781000492 active site 111781000493 Cu2+ binding site [ion binding]; other site 111781000494 Zn2+ binding site [ion binding]; other site 111781000495 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 111781000496 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 111781000497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781000498 catalytic residue [active] 111781000499 Peptidase M15; Region: Peptidase_M15_3; cl01194 111781000500 arginine decarboxylase; Provisional; Region: PRK05354 111781000501 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 111781000502 active site 111781000503 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 111781000504 catalytic residues [active] 111781000505 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 111781000506 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 111781000507 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 111781000508 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 111781000509 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781000510 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 111781000511 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781000512 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 111781000513 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 111781000514 Sulfate transporter family; Region: Sulfate_transp; pfam00916 111781000515 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 111781000516 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 111781000517 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 111781000518 Hexamer interface [polypeptide binding]; other site 111781000519 Hexagonal pore residue; other site 111781000520 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 111781000521 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 111781000522 Hexamer interface [polypeptide binding]; other site 111781000523 Hexagonal pore residue; other site 111781000524 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 111781000525 Hexamer/Pentamer interface [polypeptide binding]; other site 111781000526 central pore; other site 111781000527 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 111781000528 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 111781000529 trimer interface [polypeptide binding]; other site 111781000530 active site 111781000531 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 111781000532 putative multimerization interface [polypeptide binding]; other site 111781000533 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 111781000534 putative multimerization interface [polypeptide binding]; other site 111781000535 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 111781000536 putative multimerization interface [polypeptide binding]; other site 111781000537 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 111781000538 putative multimerization interface [polypeptide binding]; other site 111781000539 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 111781000540 putative trimer interface [polypeptide binding]; other site 111781000541 putative CoA binding site [chemical binding]; other site 111781000542 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 111781000543 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 111781000544 homodimer interface [polypeptide binding]; other site 111781000545 active site 111781000546 heterodimer interface [polypeptide binding]; other site 111781000547 catalytic residue [active] 111781000548 metal binding site [ion binding]; metal-binding site 111781000549 RbcX protein; Region: RcbX; pfam02341 111781000550 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 111781000551 multimerization interface [polypeptide binding]; other site 111781000552 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 111781000553 DHH family; Region: DHH; pfam01368 111781000554 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781000555 FOG: CBS domain [General function prediction only]; Region: COG0517 111781000556 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 111781000557 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 111781000558 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 111781000559 active site 111781000560 NTP binding site [chemical binding]; other site 111781000561 metal binding triad [ion binding]; metal-binding site 111781000562 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 111781000563 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 111781000564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781000565 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781000566 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 111781000567 HSP70 interaction site [polypeptide binding]; other site 111781000568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000569 TPR repeat; Region: TPR_11; pfam13414 111781000570 binding surface 111781000571 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781000572 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 111781000573 structural tetrad; other site 111781000574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781000575 Homeodomain-like domain; Region: HTH_32; pfam13565 111781000576 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781000577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781000578 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781000579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781000580 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781000581 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781000582 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 111781000583 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 111781000584 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781000585 putative active site [active] 111781000586 NACHT domain; Region: NACHT; pfam05729 111781000587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 111781000588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781000589 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 111781000590 putative effector binding pocket; other site 111781000591 dimerization interface [polypeptide binding]; other site 111781000592 Pirin-related protein [General function prediction only]; Region: COG1741 111781000593 Pirin; Region: Pirin; pfam02678 111781000594 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 111781000595 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 111781000596 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781000597 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781000598 phosphopeptide binding site; other site 111781000599 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781000600 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781000601 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781000602 cyclase homology domain; Region: CHD; cd07302 111781000603 nucleotidyl binding site; other site 111781000604 metal binding site [ion binding]; metal-binding site 111781000605 dimer interface [polypeptide binding]; other site 111781000606 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 111781000607 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781000608 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 111781000609 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 111781000610 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781000611 active site 111781000612 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 111781000613 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 111781000614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781000615 ATP binding site [chemical binding]; other site 111781000616 putative Mg++ binding site [ion binding]; other site 111781000617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781000618 nucleotide binding region [chemical binding]; other site 111781000619 ATP-binding site [chemical binding]; other site 111781000620 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 111781000621 HRDC domain; Region: HRDC; pfam00570 111781000622 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781000623 putative active site [active] 111781000624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781000625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781000626 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 111781000627 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781000628 DevC protein; Region: devC; TIGR01185 111781000629 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 111781000630 FtsX-like permease family; Region: FtsX; pfam02687 111781000631 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 111781000632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 111781000633 Walker A/P-loop; other site 111781000634 ATP binding site [chemical binding]; other site 111781000635 Q-loop/lid; other site 111781000636 ABC transporter signature motif; other site 111781000637 Walker B; other site 111781000638 D-loop; other site 111781000639 H-loop/switch region; other site 111781000640 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781000641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781000642 S-adenosylmethionine binding site [chemical binding]; other site 111781000643 Predicted permease [General function prediction only]; Region: COG3329 111781000644 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 111781000645 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 111781000646 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 111781000647 NADP binding site [chemical binding]; other site 111781000648 dimer interface [polypeptide binding]; other site 111781000649 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 111781000650 ligand binding site [chemical binding]; other site 111781000651 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 111781000652 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 111781000653 Rab subfamily motif 1 (RabSF1); other site 111781000654 G1 box; other site 111781000655 GTP/Mg2+ binding site [chemical binding]; other site 111781000656 Rab subfamily motif 2 (RabSF2); other site 111781000657 Switch I region; other site 111781000658 G2 box; other site 111781000659 effector interaction site; other site 111781000660 GDI interaction site; other site 111781000661 Rab family motif 1 (RabF1); other site 111781000662 GEF interaction site [polypeptide binding]; other site 111781000663 Rab family motif 2 (RabF2); other site 111781000664 G3 box; other site 111781000665 Switch II region; other site 111781000666 Rab family motif 3 (RabF3); other site 111781000667 Rab family motif 4 (RabF4); other site 111781000668 Rab family motif 5 (RabF5); other site 111781000669 Rab subfamily motif 3 (RabSF3); other site 111781000670 G4 box; other site 111781000671 G5 box; other site 111781000672 Rab subfamily motif 4 (RabSF4); other site 111781000673 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 111781000674 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 111781000675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781000676 putative active site [active] 111781000677 heme pocket [chemical binding]; other site 111781000678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781000679 dimer interface [polypeptide binding]; other site 111781000680 phosphorylation site [posttranslational modification] 111781000681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781000682 ATP binding site [chemical binding]; other site 111781000683 Mg2+ binding site [ion binding]; other site 111781000684 G-X-G motif; other site 111781000685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781000686 PAS domain; Region: PAS_9; pfam13426 111781000687 putative active site [active] 111781000688 heme pocket [chemical binding]; other site 111781000689 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781000690 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781000691 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781000692 cyclase homology domain; Region: CHD; cd07302 111781000693 nucleotidyl binding site; other site 111781000694 metal binding site [ion binding]; metal-binding site 111781000695 dimer interface [polypeptide binding]; other site 111781000696 cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926 111781000697 active site 111781000698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781000699 dimerization interface [polypeptide binding]; other site 111781000700 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781000701 cyclase homology domain; Region: CHD; cd07302 111781000702 nucleotidyl binding site; other site 111781000703 metal binding site [ion binding]; metal-binding site 111781000704 dimer interface [polypeptide binding]; other site 111781000705 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781000706 putative active site [active] 111781000707 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 111781000708 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 111781000709 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 111781000710 Walker A/P-loop; other site 111781000711 ATP binding site [chemical binding]; other site 111781000712 Q-loop/lid; other site 111781000713 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 111781000714 ABC transporter signature motif; other site 111781000715 Walker B; other site 111781000716 D-loop; other site 111781000717 H-loop/switch region; other site 111781000718 helicase 45; Provisional; Region: PTZ00424 111781000719 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 111781000720 ATP binding site [chemical binding]; other site 111781000721 Mg++ binding site [ion binding]; other site 111781000722 motif III; other site 111781000723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781000724 nucleotide binding region [chemical binding]; other site 111781000725 ATP-binding site [chemical binding]; other site 111781000726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000727 binding surface 111781000728 TPR motif; other site 111781000729 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781000730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000731 binding surface 111781000732 TPR motif; other site 111781000733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000734 binding surface 111781000735 TPR motif; other site 111781000736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000737 binding surface 111781000738 TPR motif; other site 111781000739 Peptidase family M48; Region: Peptidase_M48; pfam01435 111781000740 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 111781000741 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 111781000742 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 111781000743 putative NAD(P) binding site [chemical binding]; other site 111781000744 putative active site [active] 111781000745 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 111781000746 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 111781000747 active site 111781000748 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 111781000749 Domain of unknown function DUF20; Region: UPF0118; pfam01594 111781000750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781000751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781000752 active site 111781000753 phosphorylation site [posttranslational modification] 111781000754 intermolecular recognition site; other site 111781000755 dimerization interface [polypeptide binding]; other site 111781000756 lipoyl synthase; Provisional; Region: PRK12928 111781000757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781000758 FeS/SAM binding site; other site 111781000759 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 111781000760 S-layer homology domain; Region: SLH; pfam00395 111781000761 S-layer homology domain; Region: SLH; pfam00395 111781000762 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 111781000763 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781000764 cell division protein; Validated; Region: ftsH; CHL00176 111781000765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781000766 Walker A motif; other site 111781000767 ATP binding site [chemical binding]; other site 111781000768 Walker B motif; other site 111781000769 arginine finger; other site 111781000770 Peptidase family M41; Region: Peptidase_M41; pfam01434 111781000771 Haemolytic domain; Region: Haemolytic; pfam01809 111781000772 hydrolase, alpha/beta fold family protein; Region: PLN02824 111781000773 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781000774 Response regulator receiver domain; Region: Response_reg; pfam00072 111781000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781000776 active site 111781000777 phosphorylation site [posttranslational modification] 111781000778 intermolecular recognition site; other site 111781000779 dimerization interface [polypeptide binding]; other site 111781000780 acyl-CoA synthetase; Validated; Region: PRK05850 111781000781 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 111781000782 acyl-activating enzyme (AAE) consensus motif; other site 111781000783 active site 111781000784 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 111781000785 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 111781000786 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 111781000787 active site 111781000788 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 111781000789 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 111781000790 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 111781000791 putative NADP binding site [chemical binding]; other site 111781000792 active site 111781000793 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 111781000794 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 111781000795 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781000796 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 111781000797 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 111781000798 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 111781000799 purine monophosphate binding site [chemical binding]; other site 111781000800 dimer interface [polypeptide binding]; other site 111781000801 putative catalytic residues [active] 111781000802 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 111781000803 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 111781000804 Uncharacterized conserved protein [Function unknown]; Region: COG2361 111781000805 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781000806 active site 111781000807 NTP binding site [chemical binding]; other site 111781000808 metal binding triad [ion binding]; metal-binding site 111781000809 antibiotic binding site [chemical binding]; other site 111781000810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 111781000811 NACHT domain; Region: NACHT; pfam05729 111781000812 Walker A motif; other site 111781000813 ATP binding site [chemical binding]; other site 111781000814 Walker B motif; other site 111781000815 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 111781000816 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 111781000817 Walker A/P-loop; other site 111781000818 ATP binding site [chemical binding]; other site 111781000819 Q-loop/lid; other site 111781000820 ABC transporter signature motif; other site 111781000821 Walker B; other site 111781000822 D-loop; other site 111781000823 H-loop/switch region; other site 111781000824 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 111781000825 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 111781000826 Walker A/P-loop; other site 111781000827 ATP binding site [chemical binding]; other site 111781000828 Q-loop/lid; other site 111781000829 ABC transporter signature motif; other site 111781000830 Walker B; other site 111781000831 D-loop; other site 111781000832 H-loop/switch region; other site 111781000833 tellurium resistance terB-like protein; Region: terB_like; cd07177 111781000834 metal binding site [ion binding]; metal-binding site 111781000835 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 111781000836 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 111781000837 TM-ABC transporter signature motif; other site 111781000838 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 111781000839 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 111781000840 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 111781000841 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 111781000842 TM-ABC transporter signature motif; other site 111781000843 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 111781000844 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 111781000845 putative ligand binding site [chemical binding]; other site 111781000846 urease subunit alpha; Reviewed; Region: ureC; PRK13207 111781000847 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 111781000848 subunit interactions [polypeptide binding]; other site 111781000849 active site 111781000850 flap region; other site 111781000851 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 111781000852 UreF; Region: UreF; pfam01730 111781000853 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 111781000854 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 111781000855 dimer interface [polypeptide binding]; other site 111781000856 catalytic residues [active] 111781000857 UreD urease accessory protein; Region: UreD; pfam01774 111781000858 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 111781000859 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 111781000860 gamma-beta subunit interface [polypeptide binding]; other site 111781000861 alpha-beta subunit interface [polypeptide binding]; other site 111781000862 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 111781000863 alpha-gamma subunit interface [polypeptide binding]; other site 111781000864 beta-gamma subunit interface [polypeptide binding]; other site 111781000865 short chain dehydrogenase; Validated; Region: PRK08324 111781000866 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 111781000867 active site 111781000868 Zn2+ binding site [ion binding]; other site 111781000869 intersubunit interface [polypeptide binding]; other site 111781000870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781000871 NAD(P) binding site [chemical binding]; other site 111781000872 active site 111781000873 PAS fold; Region: PAS_4; pfam08448 111781000874 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 111781000875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781000876 dimer interface [polypeptide binding]; other site 111781000877 phosphorylation site [posttranslational modification] 111781000878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781000879 ATP binding site [chemical binding]; other site 111781000880 Mg2+ binding site [ion binding]; other site 111781000881 G-X-G motif; other site 111781000882 CHAD domain; Region: CHAD; cl10506 111781000883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 111781000884 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 111781000885 substrate binding pocket [chemical binding]; other site 111781000886 membrane-bound complex binding site; other site 111781000887 hinge residues; other site 111781000888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781000889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781000890 metal binding site [ion binding]; metal-binding site 111781000891 active site 111781000892 I-site; other site 111781000893 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781000894 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781000895 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781000896 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 111781000897 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 111781000898 active site 111781000899 catalytic residues [active] 111781000900 metal binding site [ion binding]; metal-binding site 111781000901 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 111781000902 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 111781000903 P-loop; other site 111781000904 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 111781000905 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 111781000906 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 111781000907 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 111781000908 oligomer interface [polypeptide binding]; other site 111781000909 metal binding site [ion binding]; metal-binding site 111781000910 metal binding site [ion binding]; metal-binding site 111781000911 Cl binding site [ion binding]; other site 111781000912 aspartate ring; other site 111781000913 basic sphincter; other site 111781000914 putative hydrophobic gate; other site 111781000915 periplasmic entrance; other site 111781000916 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 111781000917 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 111781000918 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 111781000919 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 111781000920 dimer interface [polypeptide binding]; other site 111781000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781000922 catalytic residue [active] 111781000923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 111781000924 putative DNA binding site [nucleotide binding]; other site 111781000925 dimerization interface [polypeptide binding]; other site 111781000926 putative Zn2+ binding site [ion binding]; other site 111781000927 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 111781000928 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 111781000929 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 111781000930 substrate binding site [chemical binding]; other site 111781000931 putative active site [active] 111781000932 redox center [active] 111781000933 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 111781000934 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781000935 CHASE2 domain; Region: CHASE2; pfam05226 111781000936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781000937 PAS fold; Region: PAS_4; pfam08448 111781000938 putative active site [active] 111781000939 heme pocket [chemical binding]; other site 111781000940 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781000941 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781000942 metal binding site [ion binding]; metal-binding site 111781000943 active site 111781000944 I-site; other site 111781000945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781000946 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781000947 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781000948 S-layer homology domain; Region: SLH; pfam00395 111781000949 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781000950 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781000951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000952 TPR motif; other site 111781000953 binding surface 111781000954 TPR repeat; Region: TPR_11; pfam13414 111781000955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000956 TPR motif; other site 111781000957 binding surface 111781000958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781000959 binding surface 111781000960 TPR motif; other site 111781000961 TPR repeat; Region: TPR_11; pfam13414 111781000962 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 111781000963 elongation factor G; Reviewed; Region: PRK12740 111781000964 G1 box; other site 111781000965 putative GEF interaction site [polypeptide binding]; other site 111781000966 GTP/Mg2+ binding site [chemical binding]; other site 111781000967 Switch I region; other site 111781000968 G2 box; other site 111781000969 G3 box; other site 111781000970 Switch II region; other site 111781000971 G4 box; other site 111781000972 G5 box; other site 111781000973 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 111781000974 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 111781000975 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 111781000976 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 111781000977 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 111781000978 putative active site [active] 111781000979 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 111781000980 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 111781000981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781000982 dimer interface [polypeptide binding]; other site 111781000983 conserved gate region; other site 111781000984 putative PBP binding loops; other site 111781000985 ABC-ATPase subunit interface; other site 111781000986 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 111781000987 active site 111781000988 dimer interface [polypeptide binding]; other site 111781000989 catalytic nucleophile [active] 111781000990 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 111781000991 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 111781000992 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 111781000993 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 111781000994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781000995 PAS fold; Region: PAS_3; pfam08447 111781000996 putative active site [active] 111781000997 heme pocket [chemical binding]; other site 111781000998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781000999 dimer interface [polypeptide binding]; other site 111781001000 phosphorylation site [posttranslational modification] 111781001001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001002 ATP binding site [chemical binding]; other site 111781001003 Mg2+ binding site [ion binding]; other site 111781001004 G-X-G motif; other site 111781001005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001006 active site 111781001007 phosphorylation site [posttranslational modification] 111781001008 intermolecular recognition site; other site 111781001009 Response regulator receiver domain; Region: Response_reg; pfam00072 111781001010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001011 active site 111781001012 phosphorylation site [posttranslational modification] 111781001013 intermolecular recognition site; other site 111781001014 dimerization interface [polypeptide binding]; other site 111781001015 Bacterial SH3 domain; Region: SH3_3; cl17532 111781001016 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 111781001017 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 111781001018 tandem repeat interface [polypeptide binding]; other site 111781001019 oligomer interface [polypeptide binding]; other site 111781001020 active site residues [active] 111781001021 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 111781001022 tandem repeat interface [polypeptide binding]; other site 111781001023 oligomer interface [polypeptide binding]; other site 111781001024 active site residues [active] 111781001025 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 111781001026 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 111781001027 homotetramer interface [polypeptide binding]; other site 111781001028 FMN binding site [chemical binding]; other site 111781001029 homodimer contacts [polypeptide binding]; other site 111781001030 putative active site [active] 111781001031 putative substrate binding site [chemical binding]; other site 111781001032 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 111781001033 MG2 domain; Region: A2M_N; pfam01835 111781001034 Alpha-2-macroglobulin family; Region: A2M; pfam00207 111781001035 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 111781001036 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 111781001037 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 111781001038 RNA binding site [nucleotide binding]; other site 111781001039 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 111781001040 RNA binding site [nucleotide binding]; other site 111781001041 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 111781001042 RNA binding site [nucleotide binding]; other site 111781001043 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781001044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001045 active site 111781001046 phosphorylation site [posttranslational modification] 111781001047 intermolecular recognition site; other site 111781001048 dimerization interface [polypeptide binding]; other site 111781001049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781001050 metal binding site [ion binding]; metal-binding site 111781001051 active site 111781001052 I-site; other site 111781001053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781001054 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 111781001055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781001056 putative active site [active] 111781001057 heme pocket [chemical binding]; other site 111781001058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781001059 dimer interface [polypeptide binding]; other site 111781001060 phosphorylation site [posttranslational modification] 111781001061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001062 ATP binding site [chemical binding]; other site 111781001063 Mg2+ binding site [ion binding]; other site 111781001064 G-X-G motif; other site 111781001065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 111781001066 MarR family; Region: MarR_2; pfam12802 111781001067 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 111781001068 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 111781001069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781001070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 111781001071 RNA methyltransferase, RsmE family; Region: TIGR00046 111781001072 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 111781001073 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 111781001074 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 111781001075 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 111781001076 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 111781001077 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781001078 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781001079 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 111781001080 active site 111781001081 substrate binding pocket [chemical binding]; other site 111781001082 dimer interface [polypeptide binding]; other site 111781001083 Cupin domain; Region: Cupin_2; cl17218 111781001084 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 111781001085 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 111781001086 active site 111781001087 Substrate binding site; other site 111781001088 Mg++ binding site; other site 111781001089 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 111781001090 putative trimer interface [polypeptide binding]; other site 111781001091 putative CoA binding site [chemical binding]; other site 111781001092 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 111781001093 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 111781001094 ribosome recycling factor; Reviewed; Region: frr; PRK00083 111781001095 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 111781001096 hinge region; other site 111781001097 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 111781001098 putative nucleotide binding site [chemical binding]; other site 111781001099 uridine monophosphate binding site [chemical binding]; other site 111781001100 homohexameric interface [polypeptide binding]; other site 111781001101 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 111781001102 Response regulator receiver domain; Region: Response_reg; pfam00072 111781001103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001104 active site 111781001105 phosphorylation site [posttranslational modification] 111781001106 intermolecular recognition site; other site 111781001107 dimerization interface [polypeptide binding]; other site 111781001108 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781001109 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781001110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781001111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781001112 dimer interface [polypeptide binding]; other site 111781001113 phosphorylation site [posttranslational modification] 111781001114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001115 ATP binding site [chemical binding]; other site 111781001116 Mg2+ binding site [ion binding]; other site 111781001117 G-X-G motif; other site 111781001118 Response regulator receiver domain; Region: Response_reg; pfam00072 111781001119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001120 active site 111781001121 phosphorylation site [posttranslational modification] 111781001122 intermolecular recognition site; other site 111781001123 dimerization interface [polypeptide binding]; other site 111781001124 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 111781001125 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781001126 Phytochrome region; Region: PHY; pfam00360 111781001127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781001128 dimer interface [polypeptide binding]; other site 111781001129 phosphorylation site [posttranslational modification] 111781001130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001131 ATP binding site [chemical binding]; other site 111781001132 Mg2+ binding site [ion binding]; other site 111781001133 G-X-G motif; other site 111781001134 30S ribosomal protein S1; Reviewed; Region: PRK07400 111781001135 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 111781001136 RNA binding site [nucleotide binding]; other site 111781001137 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 111781001138 RNA binding site [nucleotide binding]; other site 111781001139 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 111781001140 RNA binding site [nucleotide binding]; other site 111781001141 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 111781001142 ATP cone domain; Region: ATP-cone; pfam03477 111781001143 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 111781001144 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 111781001145 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 111781001146 RNA binding surface [nucleotide binding]; other site 111781001147 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 111781001148 active site 111781001149 Response regulator receiver domain; Region: Response_reg; pfam00072 111781001150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001151 active site 111781001152 phosphorylation site [posttranslational modification] 111781001153 intermolecular recognition site; other site 111781001154 dimerization interface [polypeptide binding]; other site 111781001155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781001156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781001157 dimer interface [polypeptide binding]; other site 111781001158 phosphorylation site [posttranslational modification] 111781001159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001160 ATP binding site [chemical binding]; other site 111781001161 Mg2+ binding site [ion binding]; other site 111781001162 G-X-G motif; other site 111781001163 comF family protein; Region: comF; TIGR00201 111781001164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781001165 active site 111781001166 elongation factor P; Validated; Region: PRK00529 111781001167 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 111781001168 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 111781001169 RNA binding site [nucleotide binding]; other site 111781001170 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 111781001171 RNA binding site [nucleotide binding]; other site 111781001172 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 111781001173 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 111781001174 carboxyltransferase (CT) interaction site; other site 111781001175 biotinylation site [posttranslational modification]; other site 111781001176 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 111781001177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001178 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781001179 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001181 Betaherpesvirus immediate-early glycoprotein UL37; Region: Herpes_UL37_2; cl17390 111781001182 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781001183 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781001184 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 111781001185 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 111781001186 HIGH motif; other site 111781001187 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 111781001188 active site 111781001189 KMSKS motif; other site 111781001190 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 111781001191 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 111781001192 Peptidase family M50; Region: Peptidase_M50; pfam02163 111781001193 active site 111781001194 putative substrate binding region [chemical binding]; other site 111781001195 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 111781001196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781001197 Walker A motif; other site 111781001198 ATP binding site [chemical binding]; other site 111781001199 Walker B motif; other site 111781001200 arginine finger; other site 111781001201 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 111781001202 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 111781001203 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 111781001204 active site 111781001205 Substrate binding site; other site 111781001206 Mg++ binding site; other site 111781001207 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 111781001208 putative trimer interface [polypeptide binding]; other site 111781001209 putative CoA binding site [chemical binding]; other site 111781001210 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781001211 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781001212 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781001213 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781001214 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781001215 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781001216 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781001217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781001218 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781001219 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781001220 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781001221 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 111781001222 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 111781001223 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 111781001224 NADH(P)-binding; Region: NAD_binding_10; pfam13460 111781001225 NAD(P) binding site [chemical binding]; other site 111781001226 putative active site [active] 111781001227 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 111781001228 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781001229 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781001230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781001231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781001232 dimer interface [polypeptide binding]; other site 111781001233 phosphorylation site [posttranslational modification] 111781001234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001235 ATP binding site [chemical binding]; other site 111781001236 Mg2+ binding site [ion binding]; other site 111781001237 G-X-G motif; other site 111781001238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 111781001239 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 111781001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 111781001241 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 111781001242 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 111781001243 active site 111781001244 catalytic triad [active] 111781001245 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 111781001246 TspO/MBR family; Region: TspO_MBR; cl01379 111781001247 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 111781001248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781001249 active site 111781001250 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 111781001251 protein I interface; other site 111781001252 D2 interface; other site 111781001253 protein T interface; other site 111781001254 chlorophyll binding site; other site 111781001255 beta carotene binding site; other site 111781001256 pheophytin binding site; other site 111781001257 manganese-stabilizing polypeptide interface; other site 111781001258 CP43 interface; other site 111781001259 protein L interface; other site 111781001260 oxygen evolving complex binding site; other site 111781001261 bromide binding site; other site 111781001262 quinone binding site; other site 111781001263 Fe binding site [ion binding]; other site 111781001264 core light harvesting interface; other site 111781001265 cytochrome b559 alpha subunit interface; other site 111781001266 cytochrome c-550 interface; other site 111781001267 protein J interface; other site 111781001268 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 111781001269 Pyruvate formate lyase 1; Region: PFL1; cd01678 111781001270 coenzyme A binding site [chemical binding]; other site 111781001271 active site 111781001272 catalytic residues [active] 111781001273 glycine loop; other site 111781001274 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 111781001275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781001276 FeS/SAM binding site; other site 111781001277 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 111781001278 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 111781001279 putative catalytic cysteine [active] 111781001280 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 111781001281 putative active site [active] 111781001282 metal binding site [ion binding]; metal-binding site 111781001283 Putative phosphatase (DUF442); Region: DUF442; cl17385 111781001284 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 111781001285 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 111781001286 G1 box; other site 111781001287 putative GEF interaction site [polypeptide binding]; other site 111781001288 GTP/Mg2+ binding site [chemical binding]; other site 111781001289 Switch I region; other site 111781001290 G2 box; other site 111781001291 G3 box; other site 111781001292 Switch II region; other site 111781001293 G4 box; other site 111781001294 G5 box; other site 111781001295 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 111781001296 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 111781001297 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 111781001298 putative metal binding site [ion binding]; other site 111781001299 Domain of unknown function DUF29; Region: DUF29; pfam01724 111781001300 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 111781001301 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 111781001302 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 111781001303 active site 111781001304 homodimer interface [polypeptide binding]; other site 111781001305 catalytic site [active] 111781001306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781001307 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 111781001308 active site 111781001309 motif I; other site 111781001310 motif II; other site 111781001311 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 111781001312 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 111781001313 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 111781001314 mannose binding site [chemical binding]; other site 111781001315 dimerization interface [polypeptide binding]; other site 111781001316 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 111781001317 Peptidase family M50; Region: Peptidase_M50; pfam02163 111781001318 active site 111781001319 putative substrate binding region [chemical binding]; other site 111781001320 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781001321 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 111781001322 conserved hypothetical protein; Region: TIGR02231 111781001323 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 111781001324 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 111781001325 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 111781001326 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 111781001327 active site 111781001328 nucleophile elbow; other site 111781001329 Predicted transcriptional regulators [Transcription]; Region: COG1733 111781001330 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 111781001331 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 111781001332 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 111781001333 substrate binding site [chemical binding]; other site 111781001334 oxyanion hole (OAH) forming residues; other site 111781001335 trimer interface [polypeptide binding]; other site 111781001336 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 111781001337 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 111781001338 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 111781001339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781001340 NAD(P) binding site [chemical binding]; other site 111781001341 active site 111781001342 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 111781001343 FOG: CBS domain [General function prediction only]; Region: COG0517 111781001344 FOG: CBS domain [General function prediction only]; Region: COG0517 111781001345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 111781001346 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781001347 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781001348 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781001349 PAS domain S-box; Region: sensory_box; TIGR00229 111781001350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781001351 putative active site [active] 111781001352 heme pocket [chemical binding]; other site 111781001353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781001354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781001355 metal binding site [ion binding]; metal-binding site 111781001356 active site 111781001357 I-site; other site 111781001358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781001359 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781001360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781001361 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781001362 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781001363 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 111781001364 ATP adenylyltransferase; Region: ATP_transf; pfam09830 111781001365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001366 Homeodomain-like domain; Region: HTH_32; pfam13565 111781001367 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001369 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 111781001370 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 111781001371 Walker A/P-loop; other site 111781001372 ATP binding site [chemical binding]; other site 111781001373 Q-loop/lid; other site 111781001374 ABC transporter signature motif; other site 111781001375 Walker B; other site 111781001376 D-loop; other site 111781001377 H-loop/switch region; other site 111781001378 TOBE domain; Region: TOBE_2; pfam08402 111781001379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001380 TPR motif; other site 111781001381 TPR repeat; Region: TPR_11; pfam13414 111781001382 binding surface 111781001383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001384 binding surface 111781001385 TPR motif; other site 111781001386 TPR repeat; Region: TPR_11; pfam13414 111781001387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001388 TPR repeat; Region: TPR_11; pfam13414 111781001389 binding surface 111781001390 TPR motif; other site 111781001391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781001392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781001393 dimer interface [polypeptide binding]; other site 111781001394 phosphorylation site [posttranslational modification] 111781001395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001396 ATP binding site [chemical binding]; other site 111781001397 Mg2+ binding site [ion binding]; other site 111781001398 G-X-G motif; other site 111781001399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781001400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001401 active site 111781001402 phosphorylation site [posttranslational modification] 111781001403 intermolecular recognition site; other site 111781001404 dimerization interface [polypeptide binding]; other site 111781001405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781001406 DNA binding site [nucleotide binding] 111781001407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781001408 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781001409 Methyltransferase domain; Region: Methyltransf_23; pfam13489 111781001410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781001411 S-adenosylmethionine binding site [chemical binding]; other site 111781001412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781001413 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781001414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001415 Homeodomain-like domain; Region: HTH_32; pfam13565 111781001416 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001418 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781001419 active site 111781001420 NTP binding site [chemical binding]; other site 111781001421 metal binding triad [ion binding]; metal-binding site 111781001422 Protein of unknown function DUF86; Region: DUF86; cl01031 111781001423 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781001424 active site 111781001425 NTP binding site [chemical binding]; other site 111781001426 metal binding triad [ion binding]; metal-binding site 111781001427 antibiotic binding site [chemical binding]; other site 111781001428 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781001429 putative active site [active] 111781001430 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781001431 putative active site [active] 111781001432 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 111781001433 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 111781001434 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781001435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 111781001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781001437 dimer interface [polypeptide binding]; other site 111781001438 conserved gate region; other site 111781001439 putative PBP binding loops; other site 111781001440 ABC-ATPase subunit interface; other site 111781001441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781001442 active site 111781001443 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 111781001444 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 111781001445 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 111781001446 hypothetical protein; Reviewed; Region: PRK00024 111781001447 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 111781001448 MPN+ (JAMM) motif; other site 111781001449 Zinc-binding site [ion binding]; other site 111781001450 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 111781001451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781001452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781001453 active site 111781001454 phosphorylation site [posttranslational modification] 111781001455 intermolecular recognition site; other site 111781001456 dimerization interface [polypeptide binding]; other site 111781001457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781001458 DNA binding site [nucleotide binding] 111781001459 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 111781001460 ATP-NAD kinase; Region: NAD_kinase; pfam01513 111781001461 Ycf39; Provisional; Region: ycf39; CHL00194 111781001462 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 111781001463 NAD(P) binding site [chemical binding]; other site 111781001464 putative active site [active] 111781001465 methionine sulfoxide reductase A; Provisional; Region: PRK00058 111781001466 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 111781001467 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781001468 P-loop; other site 111781001469 Magnesium ion binding site [ion binding]; other site 111781001470 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 111781001471 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 111781001472 quinolinate synthetase; Provisional; Region: PRK09375 111781001473 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781001474 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 111781001475 putative active site [active] 111781001476 putative metal binding site [ion binding]; other site 111781001477 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 111781001478 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 111781001479 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 111781001480 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 111781001481 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 111781001482 inhibitor-cofactor binding pocket; inhibition site 111781001483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781001484 catalytic residue [active] 111781001485 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 111781001486 NADH(P)-binding; Region: NAD_binding_10; pfam13460 111781001487 NAD(P) binding site [chemical binding]; other site 111781001488 putative active site [active] 111781001489 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 111781001490 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 111781001491 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 111781001492 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781001493 catalytic residue [active] 111781001494 Biofilm formation and stress response factor; Region: BsmA; pfam10014 111781001495 Biofilm formation and stress response factor; Region: BsmA; pfam10014 111781001496 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 111781001497 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 111781001498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781001499 catalytic residue [active] 111781001500 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781001501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781001502 NAD(P) binding site [chemical binding]; other site 111781001503 active site 111781001504 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 111781001505 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 111781001506 substrate-cofactor binding pocket; other site 111781001507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781001508 catalytic residue [active] 111781001509 threonine dehydratase; Provisional; Region: PRK07334 111781001510 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 111781001511 tetramer interface [polypeptide binding]; other site 111781001512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781001513 catalytic residue [active] 111781001514 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 111781001515 Protein of unknown function DUF86; Region: DUF86; cl01031 111781001516 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781001517 active site 111781001518 NTP binding site [chemical binding]; other site 111781001519 metal binding triad [ion binding]; metal-binding site 111781001520 antibiotic binding site [chemical binding]; other site 111781001521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781001522 NADH(P)-binding; Region: NAD_binding_10; pfam13460 111781001523 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781001524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781001525 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781001526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781001527 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781001528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781001529 SPFH domain / Band 7 family; Region: Band_7; pfam01145 111781001530 topology modulation protein; Reviewed; Region: PRK08118 111781001531 AAA domain; Region: AAA_17; pfam13207 111781001532 CrcB-like protein; Region: CRCB; cl09114 111781001533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 111781001534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 111781001535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 111781001536 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 111781001537 NADH(P)-binding; Region: NAD_binding_10; pfam13460 111781001538 NAD binding site [chemical binding]; other site 111781001539 substrate binding site [chemical binding]; other site 111781001540 putative active site [active] 111781001541 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 111781001542 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 111781001543 YwiC-like protein; Region: YwiC; pfam14256 111781001544 Protein kinase domain; Region: Pkinase; pfam00069 111781001545 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781001546 active site 111781001547 ATP binding site [chemical binding]; other site 111781001548 substrate binding site [chemical binding]; other site 111781001549 activation loop (A-loop); other site 111781001550 AAA ATPase domain; Region: AAA_16; pfam13191 111781001551 Predicted ATPase [General function prediction only]; Region: COG3899 111781001552 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781001553 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781001554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781001555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001556 ATP binding site [chemical binding]; other site 111781001557 Mg2+ binding site [ion binding]; other site 111781001558 G-X-G motif; other site 111781001559 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 111781001560 Na binding site [ion binding]; other site 111781001561 putative glycosylation site [posttranslational modification]; other site 111781001562 agmatinase; Region: agmatinase; TIGR01230 111781001563 Agmatinase-like family; Region: Agmatinase-like; cd09990 111781001564 active site 111781001565 oligomer interface [polypeptide binding]; other site 111781001566 Mn binding site [ion binding]; other site 111781001567 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 111781001568 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 111781001569 Walker A/P-loop; other site 111781001570 ATP binding site [chemical binding]; other site 111781001571 Q-loop/lid; other site 111781001572 ABC transporter signature motif; other site 111781001573 Walker B; other site 111781001574 D-loop; other site 111781001575 H-loop/switch region; other site 111781001576 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 111781001577 Cytochrome c; Region: Cytochrom_C; cl11414 111781001578 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 111781001579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781001580 S-adenosylmethionine binding site [chemical binding]; other site 111781001581 GTP-binding protein Der; Reviewed; Region: PRK00093 111781001582 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 111781001583 G1 box; other site 111781001584 GTP/Mg2+ binding site [chemical binding]; other site 111781001585 Switch I region; other site 111781001586 G2 box; other site 111781001587 Switch II region; other site 111781001588 G3 box; other site 111781001589 G4 box; other site 111781001590 G5 box; other site 111781001591 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 111781001592 G1 box; other site 111781001593 GTP/Mg2+ binding site [chemical binding]; other site 111781001594 Switch I region; other site 111781001595 G2 box; other site 111781001596 G3 box; other site 111781001597 Switch II region; other site 111781001598 G4 box; other site 111781001599 G5 box; other site 111781001600 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 111781001601 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 111781001602 dimer interface [polypeptide binding]; other site 111781001603 ADP-ribose binding site [chemical binding]; other site 111781001604 active site 111781001605 nudix motif; other site 111781001606 metal binding site [ion binding]; metal-binding site 111781001607 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 111781001608 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 111781001609 RNase_H superfamily; Region: RNase_H_2; pfam13482 111781001610 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 111781001611 CpeS-like protein; Region: CpeS; pfam09367 111781001612 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781001613 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 111781001614 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781001615 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781001616 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 111781001617 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781001618 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 111781001619 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 111781001620 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 111781001621 Malic enzyme, N-terminal domain; Region: malic; pfam00390 111781001622 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 111781001623 putative NAD(P) binding site [chemical binding]; other site 111781001624 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 111781001625 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 111781001626 Ligand Binding Site [chemical binding]; other site 111781001627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781001628 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781001629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001630 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781001631 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001633 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 111781001634 active site 111781001635 dinuclear metal binding site [ion binding]; other site 111781001636 dimerization interface [polypeptide binding]; other site 111781001637 CBS domain; Region: CBS; pfam00571 111781001638 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781001639 FOG: CBS domain [General function prediction only]; Region: COG0517 111781001640 FOG: CBS domain [General function prediction only]; Region: COG0517 111781001641 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 111781001642 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 111781001643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781001644 linker region; other site 111781001645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781001646 dimer interface [polypeptide binding]; other site 111781001647 phosphorylation site [posttranslational modification] 111781001648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781001649 ATP binding site [chemical binding]; other site 111781001650 G-X-G motif; other site 111781001651 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 111781001652 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 111781001653 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 111781001654 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 111781001655 dimer interface [polypeptide binding]; other site 111781001656 putative anticodon binding site; other site 111781001657 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 111781001658 motif 1; other site 111781001659 active site 111781001660 motif 2; other site 111781001661 motif 3; other site 111781001662 Predicted membrane protein [Function unknown]; Region: COG3463 111781001663 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 111781001664 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 111781001665 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 111781001666 active site 111781001667 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781001668 putative active site [active] 111781001669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 111781001670 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781001671 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781001672 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 111781001673 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 111781001674 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 111781001675 metal ion-dependent adhesion site (MIDAS); other site 111781001676 von Willebrand factor; Region: vWF_A; pfam12450 111781001677 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 111781001678 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 111781001679 metal ion-dependent adhesion site (MIDAS); other site 111781001680 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 111781001681 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 111781001682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 111781001683 minor groove reading motif; other site 111781001684 helix-hairpin-helix signature motif; other site 111781001685 substrate binding pocket [chemical binding]; other site 111781001686 active site 111781001687 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 111781001688 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781001689 anti sigma factor interaction site; other site 111781001690 regulatory phosphorylation site [posttranslational modification]; other site 111781001691 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 111781001692 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 111781001693 B12 binding site [chemical binding]; other site 111781001694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781001695 FeS/SAM binding site; other site 111781001696 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 111781001697 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 111781001698 Protein of unknown function (DUF721); Region: DUF721; cl02324 111781001699 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 111781001700 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781001701 HSP70 interaction site [polypeptide binding]; other site 111781001702 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 111781001703 AAA domain; Region: AAA_33; pfam13671 111781001704 AAA domain; Region: AAA_17; pfam13207 111781001705 MASE1; Region: MASE1; cl17823 111781001706 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 111781001707 O-Antigen ligase; Region: Wzy_C; pfam04932 111781001708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001709 TPR repeat; Region: TPR_11; pfam13414 111781001710 TPR motif; other site 111781001711 binding surface 111781001712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781001713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 111781001714 putative substrate translocation pore; other site 111781001715 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 111781001716 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 111781001717 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 111781001718 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 111781001719 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781001720 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 111781001721 carotene isomerase; Region: carot_isom; TIGR02730 111781001722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781001723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781001724 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 111781001725 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 111781001726 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 111781001727 Probable Catalytic site; other site 111781001728 metal-binding site 111781001729 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 111781001730 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 111781001731 NADP binding site [chemical binding]; other site 111781001732 active site 111781001733 putative substrate binding site [chemical binding]; other site 111781001734 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 111781001735 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 111781001736 NAD binding site [chemical binding]; other site 111781001737 substrate binding site [chemical binding]; other site 111781001738 homodimer interface [polypeptide binding]; other site 111781001739 active site 111781001740 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 111781001741 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 111781001742 substrate binding site; other site 111781001743 tetramer interface; other site 111781001744 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 111781001745 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781001746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781001747 NAD(P) binding site [chemical binding]; other site 111781001748 active site 111781001749 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 111781001750 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 111781001751 Methyltransferase domain; Region: Methyltransf_23; pfam13489 111781001752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781001753 S-adenosylmethionine binding site [chemical binding]; other site 111781001754 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 111781001755 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 111781001756 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 111781001757 NAD binding site [chemical binding]; other site 111781001758 homotetramer interface [polypeptide binding]; other site 111781001759 homodimer interface [polypeptide binding]; other site 111781001760 substrate binding site [chemical binding]; other site 111781001761 active site 111781001762 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 111781001763 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 111781001764 substrate binding site; other site 111781001765 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 111781001766 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 111781001767 Probable Catalytic site; other site 111781001768 metal-binding site 111781001769 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 111781001770 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 111781001771 Probable Catalytic site; other site 111781001772 metal-binding site 111781001773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781001774 S-adenosylmethionine binding site [chemical binding]; other site 111781001775 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 111781001776 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 111781001777 Walker A/P-loop; other site 111781001778 ATP binding site [chemical binding]; other site 111781001779 Q-loop/lid; other site 111781001780 ABC transporter signature motif; other site 111781001781 Walker B; other site 111781001782 D-loop; other site 111781001783 H-loop/switch region; other site 111781001784 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 111781001785 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 111781001786 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 111781001787 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 111781001788 NADP-binding site; other site 111781001789 homotetramer interface [polypeptide binding]; other site 111781001790 substrate binding site [chemical binding]; other site 111781001791 homodimer interface [polypeptide binding]; other site 111781001792 active site 111781001793 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 111781001794 Stage II sporulation protein; Region: SpoIID; pfam08486 111781001795 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 111781001796 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 111781001797 catalytic residues [active] 111781001798 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 111781001799 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 111781001800 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 111781001801 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 111781001802 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 111781001803 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 111781001804 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 111781001805 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 111781001806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781001807 motif II; other site 111781001808 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 111781001809 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781001810 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781001811 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781001812 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 111781001813 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 111781001814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 111781001815 Catalytic site [active] 111781001816 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 111781001817 cobalt transport protein CbiM; Validated; Region: PRK06265 111781001818 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 111781001819 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 111781001820 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 111781001821 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 111781001822 Walker A/P-loop; other site 111781001823 ATP binding site [chemical binding]; other site 111781001824 Q-loop/lid; other site 111781001825 ABC transporter signature motif; other site 111781001826 Walker B; other site 111781001827 D-loop; other site 111781001828 H-loop/switch region; other site 111781001829 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 111781001830 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 111781001831 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781001832 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 111781001833 HEAT repeats; Region: HEAT_2; pfam13646 111781001834 HEAT repeats; Region: HEAT_2; pfam13646 111781001835 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 111781001836 FOG: CBS domain [General function prediction only]; Region: COG0517 111781001837 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781001838 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 111781001839 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 111781001840 dimerization interface [polypeptide binding]; other site 111781001841 putative ATP binding site [chemical binding]; other site 111781001842 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 111781001843 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 111781001844 Pantoate-beta-alanine ligase; Region: PanC; cd00560 111781001845 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 111781001846 active site 111781001847 ATP-binding site [chemical binding]; other site 111781001848 pantoate-binding site; other site 111781001849 HXXH motif; other site 111781001850 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 111781001851 active site 111781001852 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 111781001853 CMP-binding site; other site 111781001854 The sites determining sugar specificity; other site 111781001855 aspartate aminotransferase; Provisional; Region: PRK05942 111781001856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 111781001857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781001858 homodimer interface [polypeptide binding]; other site 111781001859 catalytic residue [active] 111781001860 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781001861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781001862 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 111781001863 Walker A/P-loop; other site 111781001864 ATP binding site [chemical binding]; other site 111781001865 Q-loop/lid; other site 111781001866 ABC transporter signature motif; other site 111781001867 Walker B; other site 111781001868 D-loop; other site 111781001869 H-loop/switch region; other site 111781001870 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781001871 G3 box; other site 111781001872 Switch II region; other site 111781001873 GTP/Mg2+ binding site [chemical binding]; other site 111781001874 G4 box; other site 111781001875 G5 box; other site 111781001876 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 111781001877 hexamer (dimer of trimers) interface [polypeptide binding]; other site 111781001878 TPR repeat; Region: TPR_11; pfam13414 111781001879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001880 binding surface 111781001881 TPR motif; other site 111781001882 TPR repeat; Region: TPR_11; pfam13414 111781001883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001884 binding surface 111781001885 TPR motif; other site 111781001886 TPR repeat; Region: TPR_11; pfam13414 111781001887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001888 binding surface 111781001889 TPR motif; other site 111781001890 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781001891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001892 binding surface 111781001893 TPR motif; other site 111781001894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781001895 binding surface 111781001896 TPR motif; other site 111781001897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001898 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781001899 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001901 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 111781001902 Bacterial sugar transferase; Region: Bac_transf; pfam02397 111781001903 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 111781001904 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 111781001905 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 111781001906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781001907 motif II; other site 111781001908 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781001909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781001910 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781001911 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 111781001912 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 111781001913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781001914 Walker A/P-loop; other site 111781001915 ATP binding site [chemical binding]; other site 111781001916 Q-loop/lid; other site 111781001917 ABC transporter signature motif; other site 111781001918 Walker B; other site 111781001919 D-loop; other site 111781001920 H-loop/switch region; other site 111781001921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001922 Homeodomain-like domain; Region: HTH_32; pfam13565 111781001923 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001925 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 111781001926 ABC1 family; Region: ABC1; cl17513 111781001927 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 111781001928 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 111781001929 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 111781001930 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 111781001931 HflK protein; Region: hflK; TIGR01933 111781001932 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 111781001933 Repair protein; Region: Repair_PSII; pfam04536 111781001934 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 111781001935 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 111781001936 Rubrerythrin [Energy production and conversion]; Region: COG1592 111781001937 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 111781001938 binuclear metal center [ion binding]; other site 111781001939 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 111781001940 iron binding site [ion binding]; other site 111781001941 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 111781001942 metal binding site 2 [ion binding]; metal-binding site 111781001943 putative DNA binding helix; other site 111781001944 metal binding site 1 [ion binding]; metal-binding site 111781001945 dimer interface [polypeptide binding]; other site 111781001946 structural Zn2+ binding site [ion binding]; other site 111781001947 hydrolase, alpha/beta fold family protein; Region: PLN02824 111781001948 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781001949 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781001950 structural tetrad; other site 111781001951 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781001952 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781001953 structural tetrad; other site 111781001954 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781001955 structural tetrad; other site 111781001956 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 111781001957 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 111781001958 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 111781001959 cell division protein FtsZ; Validated; Region: PRK09330 111781001960 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 111781001961 nucleotide binding site [chemical binding]; other site 111781001962 SulA interaction site; other site 111781001963 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 111781001964 dimer interface [polypeptide binding]; other site 111781001965 substrate binding site [chemical binding]; other site 111781001966 ATP binding site [chemical binding]; other site 111781001967 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 111781001968 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 111781001969 G1 box; other site 111781001970 GTP/Mg2+ binding site [chemical binding]; other site 111781001971 Switch I region; other site 111781001972 G2 box; other site 111781001973 Switch II region; other site 111781001974 G3 box; other site 111781001975 G4 box; other site 111781001976 G5 box; other site 111781001977 Domain of unknown function (DUF697); Region: DUF697; pfam05128 111781001978 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781001979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781001980 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781001981 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781001982 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781001983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781001984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781001985 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781001986 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781001987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781001988 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 111781001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 111781001990 ATP binding site [chemical binding]; other site 111781001991 Mg2+ binding site [ion binding]; other site 111781001992 G-X-G motif; other site 111781001993 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781001994 anti sigma factor interaction site; other site 111781001995 regulatory phosphorylation site [posttranslational modification]; other site 111781001996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781001997 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 111781001998 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 111781001999 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 111781002000 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 111781002001 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 111781002002 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 111781002003 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 111781002004 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 111781002005 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 111781002006 ribonuclease E; Reviewed; Region: rne; PRK10811 111781002007 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 111781002008 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 111781002009 Phage protein D [General function prediction only]; Region: COG3500 111781002010 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 111781002011 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 111781002012 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 111781002013 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 111781002014 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 111781002015 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 111781002016 phage tail protein domain; Region: tail_TIGR02242 111781002017 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781002018 active site 111781002019 ATP binding site [chemical binding]; other site 111781002020 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781002021 substrate binding site [chemical binding]; other site 111781002022 activation loop (A-loop); other site 111781002023 cell division protein DamX; Validated; Region: PRK10905 111781002024 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 111781002025 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 111781002026 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 111781002027 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781002028 iron-sulfur cluster [ion binding]; other site 111781002029 [2Fe-2S] cluster binding site [ion binding]; other site 111781002030 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 111781002031 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 111781002032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 111781002033 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781002034 putative active site [active] 111781002035 Transcriptional regulators [Transcription]; Region: MarR; COG1846 111781002036 MarR family; Region: MarR; pfam01047 111781002037 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 111781002038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781002039 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 111781002040 dimerization interface [polypeptide binding]; other site 111781002041 substrate binding pocket [chemical binding]; other site 111781002042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002043 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781002044 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 111781002045 dimer interface [polypeptide binding]; other site 111781002046 FMN binding site [chemical binding]; other site 111781002047 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781002048 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781002049 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781002050 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781002051 Phycobilisome protein; Region: Phycobilisome; cl08227 111781002052 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 111781002053 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 111781002054 Phycobilisome protein; Region: Phycobilisome; cl08227 111781002055 Phycobilisome protein; Region: Phycobilisome; cl08227 111781002056 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781002057 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781002058 active site 111781002059 ATP binding site [chemical binding]; other site 111781002060 substrate binding site [chemical binding]; other site 111781002061 activation loop (A-loop); other site 111781002062 MASE1; Region: MASE1; pfam05231 111781002063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781002064 dimer interface [polypeptide binding]; other site 111781002065 phosphorylation site [posttranslational modification] 111781002066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781002067 ATP binding site [chemical binding]; other site 111781002068 Mg2+ binding site [ion binding]; other site 111781002069 G-X-G motif; other site 111781002070 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 111781002071 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 111781002072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 111781002073 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 111781002074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002075 Homeodomain-like domain; Region: HTH_23; cl17451 111781002076 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781002077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781002078 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002079 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781002081 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002082 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781002084 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 111781002085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781002086 S-adenosylmethionine binding site [chemical binding]; other site 111781002087 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 111781002088 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 111781002089 NAD binding site [chemical binding]; other site 111781002090 homotetramer interface [polypeptide binding]; other site 111781002091 homodimer interface [polypeptide binding]; other site 111781002092 substrate binding site [chemical binding]; other site 111781002093 active site 111781002094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781002095 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 111781002096 ligand binding site [chemical binding]; other site 111781002097 flexible hinge region; other site 111781002098 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 111781002099 putative switch regulator; other site 111781002100 non-specific DNA interactions [nucleotide binding]; other site 111781002101 DNA binding site [nucleotide binding] 111781002102 sequence specific DNA binding site [nucleotide binding]; other site 111781002103 putative cAMP binding site [chemical binding]; other site 111781002104 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 111781002105 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 111781002106 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 111781002107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781002108 Homeodomain-like domain; Region: HTH_32; pfam13565 111781002109 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781002111 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781002112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002113 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002114 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781002115 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 111781002116 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 111781002117 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 111781002118 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 111781002119 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 111781002120 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 111781002121 putative ligand binding site [chemical binding]; other site 111781002122 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 111781002123 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781002124 DDE superfamily endonuclease; Region: DDE_4; pfam13359 111781002125 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 111781002126 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 111781002127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781002128 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002129 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781002131 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 111781002132 AAA domain; Region: AAA_31; pfam13614 111781002133 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781002134 P-loop; other site 111781002135 Magnesium ion binding site [ion binding]; other site 111781002136 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781002137 Magnesium ion binding site [ion binding]; other site 111781002138 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 111781002139 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 111781002140 NAD binding site [chemical binding]; other site 111781002141 substrate binding site [chemical binding]; other site 111781002142 homodimer interface [polypeptide binding]; other site 111781002143 active site 111781002144 RNA polymerase sigma factor; Validated; Region: PRK05949 111781002145 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 111781002146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781002147 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 111781002148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781002149 DNA binding residues [nucleotide binding] 111781002150 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 111781002151 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781002152 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781002153 active site 111781002154 ATP binding site [chemical binding]; other site 111781002155 substrate binding site [chemical binding]; other site 111781002156 activation loop (A-loop); other site 111781002157 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 111781002158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781002159 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781002160 active site 111781002161 ATP binding site [chemical binding]; other site 111781002162 substrate binding site [chemical binding]; other site 111781002163 activation loop (A-loop); other site 111781002164 Bacterial SH3 domain; Region: SH3_3; cl17532 111781002165 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781002166 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 111781002167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 111781002168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781002169 homodimer interface [polypeptide binding]; other site 111781002170 catalytic residue [active] 111781002171 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 111781002172 DDE superfamily endonuclease; Region: DDE_4; cl17710 111781002173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002174 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781002175 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002177 active site 111781002178 phosphorylation site [posttranslational modification] 111781002179 intermolecular recognition site; other site 111781002180 dimerization interface [polypeptide binding]; other site 111781002181 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002183 active site 111781002184 phosphorylation site [posttranslational modification] 111781002185 intermolecular recognition site; other site 111781002186 dimerization interface [polypeptide binding]; other site 111781002187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002188 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002189 active site 111781002190 phosphorylation site [posttranslational modification] 111781002191 intermolecular recognition site; other site 111781002192 dimerization interface [polypeptide binding]; other site 111781002193 CheW-like domain; Region: CheW; pfam01584 111781002194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 111781002195 TPR motif; other site 111781002196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781002197 dimerization interface [polypeptide binding]; other site 111781002198 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 111781002199 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 111781002200 dimer interface [polypeptide binding]; other site 111781002201 putative CheW interface [polypeptide binding]; other site 111781002202 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 111781002203 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 111781002204 putative binding surface; other site 111781002205 active site 111781002206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781002207 ATP binding site [chemical binding]; other site 111781002208 Mg2+ binding site [ion binding]; other site 111781002209 G-X-G motif; other site 111781002210 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 111781002211 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781002212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002213 active site 111781002214 phosphorylation site [posttranslational modification] 111781002215 intermolecular recognition site; other site 111781002216 dimerization interface [polypeptide binding]; other site 111781002217 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781002218 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 111781002219 HSP70 interaction site [polypeptide binding]; other site 111781002220 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 111781002221 MoaE interaction surface [polypeptide binding]; other site 111781002222 MoeB interaction surface [polypeptide binding]; other site 111781002223 thiocarboxylated glycine; other site 111781002224 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 111781002225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 111781002226 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 111781002227 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 111781002228 dimerization interface [polypeptide binding]; other site 111781002229 putative ATP binding site [chemical binding]; other site 111781002230 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 111781002231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781002232 Coenzyme A binding pocket [chemical binding]; other site 111781002233 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 111781002234 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 111781002235 minor groove reading motif; other site 111781002236 helix-hairpin-helix signature motif; other site 111781002237 substrate binding pocket [chemical binding]; other site 111781002238 active site 111781002239 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 111781002240 DNA binding and oxoG recognition site [nucleotide binding] 111781002241 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 111781002242 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 111781002243 B12 binding site [chemical binding]; other site 111781002244 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 111781002245 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 111781002246 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 111781002247 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 111781002248 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 111781002249 DNA protecting protein DprA; Region: dprA; TIGR00732 111781002250 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 111781002251 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 111781002252 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 111781002253 heme binding pocket [chemical binding]; other site 111781002254 heme ligand [chemical binding]; other site 111781002255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 111781002256 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 111781002257 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 111781002258 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 111781002259 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781002260 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781002261 catalytic loop [active] 111781002262 iron binding site [ion binding]; other site 111781002263 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 111781002264 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781002265 Ligand Binding Site [chemical binding]; other site 111781002266 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781002267 Ligand Binding Site [chemical binding]; other site 111781002268 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 111781002269 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 111781002270 putative active site [active] 111781002271 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 111781002272 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 111781002273 Leucine-rich repeats; other site 111781002274 Substrate binding site [chemical binding]; other site 111781002275 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 111781002276 Leucine-rich repeats; other site 111781002277 Substrate binding site [chemical binding]; other site 111781002278 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 111781002279 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 111781002280 Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914 111781002281 G1 box; other site 111781002282 GTP/Mg2+ binding site [chemical binding]; other site 111781002283 G2 box; other site 111781002284 Switch I region; other site 111781002285 G3 box; other site 111781002286 Switch II region; other site 111781002287 G4 box; other site 111781002288 G5 box; other site 111781002289 Phytochelatin synthase; Region: Phytochelatin; pfam05023 111781002290 PAS domain S-box; Region: sensory_box; TIGR00229 111781002291 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781002292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781002293 metal binding site [ion binding]; metal-binding site 111781002294 active site 111781002295 I-site; other site 111781002296 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 111781002297 prephenate dehydratase; Provisional; Region: PRK11898 111781002298 Prephenate dehydratase; Region: PDT; pfam00800 111781002299 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 111781002300 putative L-Phe binding site [chemical binding]; other site 111781002301 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 111781002302 amidohydrolase; Region: amidohydrolases; TIGR01891 111781002303 metal binding site [ion binding]; metal-binding site 111781002304 dimer interface [polypeptide binding]; other site 111781002305 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781002306 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 111781002307 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 111781002308 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 111781002309 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 111781002310 Walker A/P-loop; other site 111781002311 ATP binding site [chemical binding]; other site 111781002312 Q-loop/lid; other site 111781002313 ABC transporter signature motif; other site 111781002314 Walker B; other site 111781002315 D-loop; other site 111781002316 H-loop/switch region; other site 111781002317 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 111781002318 mce related protein; Region: MCE; pfam02470 111781002319 pantothenate kinase; Reviewed; Region: PRK13331 111781002320 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 111781002321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 111781002322 protein binding site [polypeptide binding]; other site 111781002323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 111781002324 Zn2+ binding site [ion binding]; other site 111781002325 Mg2+ binding site [ion binding]; other site 111781002326 PQQ-like domain; Region: PQQ_2; pfam13360 111781002327 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 111781002328 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 111781002329 enolase; Region: PLN00191 111781002330 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 111781002331 dimer interface [polypeptide binding]; other site 111781002332 [2Fe-2S] cluster binding site [ion binding]; other site 111781002333 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 111781002334 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781002335 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 111781002336 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 111781002337 active site 111781002338 interdomain interaction site; other site 111781002339 putative metal-binding site [ion binding]; other site 111781002340 nucleotide binding site [chemical binding]; other site 111781002341 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 111781002342 domain I; other site 111781002343 phosphate binding site [ion binding]; other site 111781002344 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 111781002345 domain II; other site 111781002346 domain III; other site 111781002347 nucleotide binding site [chemical binding]; other site 111781002348 DNA binding groove [nucleotide binding] 111781002349 catalytic site [active] 111781002350 domain IV; other site 111781002351 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 111781002352 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 111781002353 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 111781002354 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 111781002355 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 111781002356 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 111781002357 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 111781002358 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 111781002359 ABC1 family; Region: ABC1; cl17513 111781002360 ribonuclease III; Reviewed; Region: rnc; PRK00102 111781002361 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 111781002362 dimerization interface [polypeptide binding]; other site 111781002363 active site 111781002364 metal binding site [ion binding]; metal-binding site 111781002365 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 111781002366 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 111781002367 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 111781002368 putative hydrolase; Provisional; Region: PRK11460 111781002369 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 111781002370 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 111781002371 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 111781002372 putative active site [active] 111781002373 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 111781002374 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 111781002375 tRNA; other site 111781002376 putative tRNA binding site [nucleotide binding]; other site 111781002377 putative NADP binding site [chemical binding]; other site 111781002378 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 111781002379 PsbP; Region: PsbP; pfam01789 111781002380 Maf-like protein; Region: Maf; pfam02545 111781002381 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 111781002382 active site 111781002383 dimer interface [polypeptide binding]; other site 111781002384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781002385 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002386 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781002388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781002389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002390 active site 111781002391 phosphorylation site [posttranslational modification] 111781002392 intermolecular recognition site; other site 111781002393 dimerization interface [polypeptide binding]; other site 111781002394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781002395 DNA binding site [nucleotide binding] 111781002396 Thymidylate synthase complementing protein; Region: Thy1; cl03630 111781002397 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 111781002398 protein-splicing catalytic site; other site 111781002399 thioester formation/cholesterol transfer; other site 111781002400 Thymidylate synthase complementing protein; Region: Thy1; cl03630 111781002401 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 111781002402 trimer interface [polypeptide binding]; other site 111781002403 active site 111781002404 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 111781002405 Psb28 protein; Region: Psb28; pfam03912 111781002406 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 111781002407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781002408 putative substrate translocation pore; other site 111781002409 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 111781002410 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 111781002411 [4Fe-4S] binding site [ion binding]; other site 111781002412 molybdopterin cofactor binding site; other site 111781002413 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 111781002414 molybdopterin cofactor binding site; other site 111781002415 proton extrusion protein PcxA; Provisional; Region: PRK02507 111781002416 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 111781002417 Low molecular weight phosphatase family; Region: LMWPc; cd00115 111781002418 active site 111781002419 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 111781002420 putative di-iron ligands [ion binding]; other site 111781002421 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 111781002422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 111781002423 dimerization interface [polypeptide binding]; other site 111781002424 putative DNA binding site [nucleotide binding]; other site 111781002425 putative Zn2+ binding site [ion binding]; other site 111781002426 Rubrerythrin [Energy production and conversion]; Region: COG1592 111781002427 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 111781002428 substrate binding site [chemical binding]; other site 111781002429 active site 111781002430 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 111781002431 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 111781002432 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 111781002433 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 111781002434 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 111781002435 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 111781002436 active site 111781002437 homotetramer interface [polypeptide binding]; other site 111781002438 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 111781002439 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 111781002440 active site 111781002441 catalytic site [active] 111781002442 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 111781002443 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 111781002444 N- and C-terminal domain interface [polypeptide binding]; other site 111781002445 active site 111781002446 MgATP binding site [chemical binding]; other site 111781002447 catalytic site [active] 111781002448 metal binding site [ion binding]; metal-binding site 111781002449 glycerol binding site [chemical binding]; other site 111781002450 homotetramer interface [polypeptide binding]; other site 111781002451 homodimer interface [polypeptide binding]; other site 111781002452 FBP binding site [chemical binding]; other site 111781002453 protein IIAGlc interface [polypeptide binding]; other site 111781002454 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 111781002455 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 111781002456 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 111781002457 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 111781002458 Walker A/P-loop; other site 111781002459 ATP binding site [chemical binding]; other site 111781002460 Q-loop/lid; other site 111781002461 ABC transporter signature motif; other site 111781002462 Walker B; other site 111781002463 D-loop; other site 111781002464 H-loop/switch region; other site 111781002465 TOBE domain; Region: TOBE_2; pfam08402 111781002466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 111781002467 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 111781002468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 111781002469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781002470 conserved gate region; other site 111781002471 dimer interface [polypeptide binding]; other site 111781002472 putative PBP binding loops; other site 111781002473 ABC-ATPase subunit interface; other site 111781002474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 111781002475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781002476 dimer interface [polypeptide binding]; other site 111781002477 conserved gate region; other site 111781002478 putative PBP binding loops; other site 111781002479 ABC-ATPase subunit interface; other site 111781002480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781002481 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 111781002482 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 111781002483 Protein of unknown function, DUF393; Region: DUF393; pfam04134 111781002484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 111781002485 catalytic core [active] 111781002486 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 111781002487 catalytic core [active] 111781002488 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 111781002489 tartrate dehydrogenase; Region: TTC; TIGR02089 111781002490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781002491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781002492 dimerization interface [polypeptide binding]; other site 111781002493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781002494 dimer interface [polypeptide binding]; other site 111781002495 phosphorylation site [posttranslational modification] 111781002496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781002497 ATP binding site [chemical binding]; other site 111781002498 Mg2+ binding site [ion binding]; other site 111781002499 G-X-G motif; other site 111781002500 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002502 active site 111781002503 phosphorylation site [posttranslational modification] 111781002504 intermolecular recognition site; other site 111781002505 dimerization interface [polypeptide binding]; other site 111781002506 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 111781002507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 111781002508 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 111781002509 flavoprotein, HI0933 family; Region: TIGR00275 111781002510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781002511 binding surface 111781002512 TPR repeat; Region: TPR_11; pfam13414 111781002513 TPR motif; other site 111781002514 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 111781002515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 111781002516 substrate binding pocket [chemical binding]; other site 111781002517 membrane-bound complex binding site; other site 111781002518 hinge residues; other site 111781002519 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 111781002520 23S rRNA binding site [nucleotide binding]; other site 111781002521 L21 binding site [polypeptide binding]; other site 111781002522 L13 binding site [polypeptide binding]; other site 111781002523 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 111781002524 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 111781002525 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 111781002526 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 111781002527 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781002528 Domain of unknown function DUF11; Region: DUF11; cl17728 111781002529 Right handed beta helix region; Region: Beta_helix; pfam13229 111781002530 Domain of unknown function DUF11; Region: DUF11; cl17728 111781002531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 111781002532 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 111781002533 metal ion-dependent adhesion site (MIDAS); other site 111781002534 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 111781002535 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781002536 HSP70 interaction site [polypeptide binding]; other site 111781002537 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781002538 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002539 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002540 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 111781002545 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 111781002546 5-oxoprolinase; Region: PLN02666 111781002547 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 111781002548 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 111781002549 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 111781002550 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 111781002551 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 111781002552 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 111781002553 RNA binding surface [nucleotide binding]; other site 111781002554 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 111781002555 active site 111781002556 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 111781002557 Helix-turn-helix domain; Region: HTH_25; pfam13413 111781002558 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 111781002559 Predicted methyltransferases [General function prediction only]; Region: COG0313 111781002560 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 111781002561 putative SAM binding site [chemical binding]; other site 111781002562 putative homodimer interface [polypeptide binding]; other site 111781002563 PAS domain S-box; Region: sensory_box; TIGR00229 111781002564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781002565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781002566 metal binding site [ion binding]; metal-binding site 111781002567 active site 111781002568 I-site; other site 111781002569 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781002570 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 111781002571 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 111781002572 substrate binding site [chemical binding]; other site 111781002573 ATP binding site [chemical binding]; other site 111781002574 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 111781002575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781002576 S-adenosylmethionine binding site [chemical binding]; other site 111781002577 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 111781002578 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 111781002579 active site 111781002580 homodimer interface [polypeptide binding]; other site 111781002581 catalytic site [active] 111781002582 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 111781002583 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781002584 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 111781002585 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 111781002586 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781002587 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 111781002588 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 111781002589 active site 111781002590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781002591 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 111781002592 trimer interface [polypeptide binding]; other site 111781002593 active site 111781002594 substrate binding site [chemical binding]; other site 111781002595 CoA binding site [chemical binding]; other site 111781002596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781002597 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781002598 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 111781002599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781002600 active site 111781002601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781002602 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781002603 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 111781002604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781002605 active site 111781002606 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 111781002607 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 111781002608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 111781002609 motif II; other site 111781002610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781002611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781002612 S-layer homology domain; Region: SLH; pfam00395 111781002613 S-layer homology domain; Region: SLH; pfam00395 111781002614 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 111781002615 DNA photolyase; Region: DNA_photolyase; pfam00875 111781002616 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 111781002617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 111781002618 substrate binding pocket [chemical binding]; other site 111781002619 membrane-bound complex binding site; other site 111781002620 hinge residues; other site 111781002621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 111781002622 Predicted kinase [General function prediction only]; Region: COG0645 111781002623 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 111781002624 ATP-binding site [chemical binding]; other site 111781002625 Gluconate-6-phosphate binding site [chemical binding]; other site 111781002626 Exoribonuclease R [Transcription]; Region: VacB; COG0557 111781002627 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 111781002628 RNB domain; Region: RNB; pfam00773 111781002629 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 111781002630 RNA binding site [nucleotide binding]; other site 111781002631 Src Homology 3 domain superfamily; Region: SH3; cl17036 111781002632 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 111781002633 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 111781002634 putative active site [active] 111781002635 catalytic triad [active] 111781002636 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 111781002637 Predicted permeases [General function prediction only]; Region: COG0701 111781002638 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002640 active site 111781002641 phosphorylation site [posttranslational modification] 111781002642 intermolecular recognition site; other site 111781002643 dimerization interface [polypeptide binding]; other site 111781002644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781002645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781002646 dimer interface [polypeptide binding]; other site 111781002647 phosphorylation site [posttranslational modification] 111781002648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781002649 ATP binding site [chemical binding]; other site 111781002650 Mg2+ binding site [ion binding]; other site 111781002651 G-X-G motif; other site 111781002652 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 111781002653 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 111781002654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 111781002655 RNA binding surface [nucleotide binding]; other site 111781002656 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 111781002657 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 111781002658 nucleotide binding site [chemical binding]; other site 111781002659 NEF interaction site [polypeptide binding]; other site 111781002660 SBD interface [polypeptide binding]; other site 111781002661 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781002662 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781002663 Winged helix-turn helix; Region: HTH_29; pfam13551 111781002664 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002665 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781002667 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781002668 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 111781002669 active site 111781002670 catalytic residues [active] 111781002671 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 111781002672 bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678 111781002673 bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678 111781002674 Methyltransferase domain; Region: Methyltransf_23; pfam13489 111781002675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781002676 S-adenosylmethionine binding site [chemical binding]; other site 111781002677 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 111781002678 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 111781002679 intermolecular salt bridges; other site 111781002680 calcium mediated ligand binding site; other site 111781002681 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 111781002682 calcium mediated ligand binding site; other site 111781002683 intermolecular salt bridges; other site 111781002684 cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220 111781002685 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 111781002686 putative active site [active] 111781002687 putative catalytic triad [active] 111781002688 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 111781002689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781002690 Homeodomain-like domain; Region: HTH_32; pfam13565 111781002691 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781002692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781002693 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781002694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781002695 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 111781002696 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 111781002697 putative active site [active] 111781002698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002699 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781002700 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 111781002701 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 111781002702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781002703 TPR motif; other site 111781002704 binding surface 111781002705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781002706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781002707 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781002708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781002709 binding surface 111781002710 TPR motif; other site 111781002711 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781002712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781002713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781002714 binding surface 111781002715 TPR motif; other site 111781002716 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781002717 CHAT domain; Region: CHAT; pfam12770 111781002718 phage shock protein A; Region: phageshock_pspA; TIGR02977 111781002719 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 111781002720 catalytic residues [active] 111781002721 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 111781002722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 111781002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781002724 homodimer interface [polypeptide binding]; other site 111781002725 catalytic residue [active] 111781002726 phosphoenolpyruvate synthase; Validated; Region: PRK06241 111781002727 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 111781002728 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 111781002729 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 111781002730 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 111781002731 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 111781002732 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 111781002733 KaiA domain; Region: KaiA; pfam07688 111781002734 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 111781002735 tetramer interface [polypeptide binding]; other site 111781002736 dimer interface [polypeptide binding]; other site 111781002737 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 111781002738 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 111781002739 Walker A motif; other site 111781002740 ATP binding site [chemical binding]; other site 111781002741 Walker B motif; other site 111781002742 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 111781002743 ATP binding site [chemical binding]; other site 111781002744 Walker B motif; other site 111781002745 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 111781002746 L11 interface [polypeptide binding]; other site 111781002747 putative EF-Tu interaction site [polypeptide binding]; other site 111781002748 putative EF-G interaction site [polypeptide binding]; other site 111781002749 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002751 active site 111781002752 phosphorylation site [posttranslational modification] 111781002753 intermolecular recognition site; other site 111781002754 dimerization interface [polypeptide binding]; other site 111781002755 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 111781002756 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 111781002757 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002758 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781002759 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002760 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002761 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781002762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002763 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 111781002764 O-Antigen ligase; Region: Wzy_C; pfam04932 111781002765 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781002766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781002767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781002768 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781002769 NAD(P) binding site [chemical binding]; other site 111781002770 active site 111781002771 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 111781002772 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 111781002773 cofactor binding site; other site 111781002774 DNA binding site [nucleotide binding] 111781002775 substrate interaction site [chemical binding]; other site 111781002776 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 111781002777 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 111781002778 Amidinotransferase; Region: Amidinotransf; cl12043 111781002779 Uncharacterized conserved protein [Function unknown]; Region: COG1915 111781002780 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 111781002781 homodimer interface [polypeptide binding]; other site 111781002782 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 111781002783 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 111781002784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781002785 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 111781002786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781002787 DNA binding residues [nucleotide binding] 111781002788 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781002789 cyclase homology domain; Region: CHD; cd07302 111781002790 nucleotidyl binding site; other site 111781002791 metal binding site [ion binding]; metal-binding site 111781002792 dimer interface [polypeptide binding]; other site 111781002793 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 111781002794 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 111781002795 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 111781002796 substrate binding site [chemical binding]; other site 111781002797 oxyanion hole (OAH) forming residues; other site 111781002798 trimer interface [polypeptide binding]; other site 111781002799 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 111781002800 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 111781002801 active site 111781002802 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 111781002803 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 111781002804 30S subunit binding site; other site 111781002805 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 111781002806 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781002807 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781002808 phosphopeptide binding site; other site 111781002809 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781002810 cyclase homology domain; Region: CHD; cd07302 111781002811 nucleotidyl binding site; other site 111781002812 metal binding site [ion binding]; metal-binding site 111781002813 dimer interface [polypeptide binding]; other site 111781002814 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 111781002815 Bacitracin resistance protein BacA; Region: BacA; pfam02673 111781002816 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 111781002817 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 111781002818 Protein of unknown function (DUF512); Region: DUF512; pfam04459 111781002819 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781002820 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002821 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781002822 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002823 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002824 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781002825 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 111781002826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 111781002827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781002828 DNA binding residues [nucleotide binding] 111781002829 dimerization interface [polypeptide binding]; other site 111781002830 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 111781002831 catalytic triad [active] 111781002832 conserved cis-peptide bond; other site 111781002833 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 111781002834 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 111781002835 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 111781002836 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 111781002837 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781002838 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781002839 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781002840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002841 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781002842 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781002843 Predicted permease; Region: DUF318; cl17795 111781002844 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 111781002845 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 111781002846 active site 111781002847 ribulose/triose binding site [chemical binding]; other site 111781002848 phosphate binding site [ion binding]; other site 111781002849 substrate (anthranilate) binding pocket [chemical binding]; other site 111781002850 product (indole) binding pocket [chemical binding]; other site 111781002851 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 111781002852 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 111781002853 B12 binding site [chemical binding]; other site 111781002854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 111781002855 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781002856 binding surface 111781002857 TPR motif; other site 111781002858 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 111781002859 active site 111781002860 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781002861 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 111781002862 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 111781002863 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 111781002864 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781002865 active site 111781002866 NTP binding site [chemical binding]; other site 111781002867 metal binding triad [ion binding]; metal-binding site 111781002868 antibiotic binding site [chemical binding]; other site 111781002869 Uncharacterized conserved protein [Function unknown]; Region: COG1479 111781002870 Protein of unknown function DUF262; Region: DUF262; pfam03235 111781002871 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 111781002872 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 111781002873 MutS domain I; Region: MutS_I; pfam01624 111781002874 MutS domain II; Region: MutS_II; pfam05188 111781002875 MutS domain III; Region: MutS_III; pfam05192 111781002876 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 111781002877 Walker A/P-loop; other site 111781002878 ATP binding site [chemical binding]; other site 111781002879 Q-loop/lid; other site 111781002880 ABC transporter signature motif; other site 111781002881 Walker B; other site 111781002882 D-loop; other site 111781002883 H-loop/switch region; other site 111781002884 Divergent AAA domain; Region: AAA_4; pfam04326 111781002885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002886 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781002887 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 111781002888 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 111781002889 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 111781002890 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 111781002891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 111781002892 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 111781002893 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 111781002894 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 111781002895 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 111781002896 putative metal binding site [ion binding]; other site 111781002897 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 111781002898 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 111781002899 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 111781002900 trimer interface [polypeptide binding]; other site 111781002901 active site 111781002902 UDP-GlcNAc binding site [chemical binding]; other site 111781002903 lipid binding site [chemical binding]; lipid-binding site 111781002904 elongation factor Tu; Reviewed; Region: PRK00049 111781002905 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781002906 G1 box; other site 111781002907 GTP/Mg2+ binding site [chemical binding]; other site 111781002908 G2 box; other site 111781002909 Switch I region; other site 111781002910 G3 box; other site 111781002911 Switch II region; other site 111781002912 G4 box; other site 111781002913 G5 box; other site 111781002914 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 111781002915 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 111781002916 Antibiotic Binding Site [chemical binding]; other site 111781002917 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 111781002918 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 111781002919 FMN binding site [chemical binding]; other site 111781002920 active site 111781002921 catalytic residues [active] 111781002922 substrate binding site [chemical binding]; other site 111781002923 Response regulator receiver domain; Region: Response_reg; pfam00072 111781002924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002925 active site 111781002926 phosphorylation site [posttranslational modification] 111781002927 intermolecular recognition site; other site 111781002928 dimerization interface [polypeptide binding]; other site 111781002929 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781002930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781002931 metal binding site [ion binding]; metal-binding site 111781002932 active site 111781002933 I-site; other site 111781002934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781002935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781002936 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781002937 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781002938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781002939 active site 111781002940 phosphorylation site [posttranslational modification] 111781002941 intermolecular recognition site; other site 111781002942 dimerization interface [polypeptide binding]; other site 111781002943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781002944 DNA binding site [nucleotide binding] 111781002945 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 111781002946 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 111781002947 putative RNA binding site [nucleotide binding]; other site 111781002948 Uncharacterized conserved protein [Function unknown]; Region: COG2928 111781002949 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 111781002950 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 111781002951 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 111781002952 putative active site [active] 111781002953 Double zinc ribbon; Region: DZR; pfam12773 111781002954 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 111781002955 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 111781002956 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781002957 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781002958 phosphopeptide binding site; other site 111781002959 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781002960 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781002961 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 111781002962 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 111781002963 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 111781002964 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 111781002965 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 111781002966 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 111781002967 NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015 111781002968 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 111781002969 active site 111781002970 catalytic site [active] 111781002971 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 111781002972 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 111781002973 Lipoxygenase; Region: Lipoxygenase; pfam00305 111781002974 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 111781002975 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 111781002976 active site 111781002977 dimer interface [polypeptide binding]; other site 111781002978 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 111781002979 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 111781002980 active site 111781002981 FMN binding site [chemical binding]; other site 111781002982 substrate binding site [chemical binding]; other site 111781002983 3Fe-4S cluster binding site [ion binding]; other site 111781002984 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 111781002985 domain interface; other site 111781002986 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 111781002987 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 111781002988 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 111781002989 Caspase domain; Region: Peptidase_C14; pfam00656 111781002990 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781002991 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781002992 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 111781002993 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 111781002994 dimerization interface [polypeptide binding]; other site 111781002995 active site 111781002996 metal binding site [ion binding]; metal-binding site 111781002997 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 111781002998 dsRNA binding site [nucleotide binding]; other site 111781002999 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 111781003000 active site 111781003001 8-oxo-dGMP binding site [chemical binding]; other site 111781003002 nudix motif; other site 111781003003 metal binding site [ion binding]; metal-binding site 111781003004 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 111781003005 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 111781003006 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 111781003007 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 111781003008 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 111781003009 Walker A/P-loop; other site 111781003010 ATP binding site [chemical binding]; other site 111781003011 Q-loop/lid; other site 111781003012 ABC transporter signature motif; other site 111781003013 Walker B; other site 111781003014 D-loop; other site 111781003015 H-loop/switch region; other site 111781003016 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 111781003017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781003018 dimer interface [polypeptide binding]; other site 111781003019 conserved gate region; other site 111781003020 putative PBP binding loops; other site 111781003021 ABC-ATPase subunit interface; other site 111781003022 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 111781003023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781003024 dimer interface [polypeptide binding]; other site 111781003025 conserved gate region; other site 111781003026 putative PBP binding loops; other site 111781003027 ABC-ATPase subunit interface; other site 111781003028 PBP superfamily domain; Region: PBP_like_2; cl17296 111781003029 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 111781003030 von Willebrand factor (vWF) type D domain; Region: VWD; smart00216 111781003031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781003032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003033 active site 111781003034 phosphorylation site [posttranslational modification] 111781003035 intermolecular recognition site; other site 111781003036 dimerization interface [polypeptide binding]; other site 111781003037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781003038 DNA binding site [nucleotide binding] 111781003039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003040 HAMP domain; Region: HAMP; pfam00672 111781003041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003042 dimer interface [polypeptide binding]; other site 111781003043 phosphorylation site [posttranslational modification] 111781003044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003045 ATP binding site [chemical binding]; other site 111781003046 G-X-G motif; other site 111781003047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781003048 S-adenosylmethionine binding site [chemical binding]; other site 111781003049 MOSC domain; Region: MOSC; pfam03473 111781003050 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 111781003051 DNA binding site [nucleotide binding] 111781003052 active site 111781003053 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 111781003054 geranylgeranyl reductase; Region: ChlP; TIGR02028 111781003055 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 111781003056 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781003057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781003058 Coenzyme A binding pocket [chemical binding]; other site 111781003059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781003060 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 111781003061 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 111781003062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781003063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781003064 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 111781003065 putative ADP-binding pocket [chemical binding]; other site 111781003066 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 111781003067 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 111781003068 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 111781003069 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 111781003070 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 111781003071 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781003072 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 111781003073 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781003074 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 111781003075 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 111781003076 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 111781003077 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 111781003078 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 111781003079 Sulfate transporter family; Region: Sulfate_transp; pfam00916 111781003080 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 111781003081 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 111781003082 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 111781003083 active site 111781003084 substrate binding site [chemical binding]; other site 111781003085 metal binding site [ion binding]; metal-binding site 111781003086 Response regulator receiver domain; Region: Response_reg; pfam00072 111781003087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003088 active site 111781003089 phosphorylation site [posttranslational modification] 111781003090 intermolecular recognition site; other site 111781003091 dimerization interface [polypeptide binding]; other site 111781003092 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 111781003093 EVE domain; Region: EVE; pfam01878 111781003094 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 111781003095 Protein of unknown function (DUF815); Region: DUF815; pfam05673 111781003096 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 111781003097 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 111781003098 dimer interface [polypeptide binding]; other site 111781003099 substrate binding site [chemical binding]; other site 111781003100 metal binding sites [ion binding]; metal-binding site 111781003101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781003102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781003103 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 111781003104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781003105 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 111781003106 putative switch regulator; other site 111781003107 non-specific DNA interactions [nucleotide binding]; other site 111781003108 DNA binding site [nucleotide binding] 111781003109 sequence specific DNA binding site [nucleotide binding]; other site 111781003110 putative cAMP binding site [chemical binding]; other site 111781003111 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 111781003112 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 111781003113 HAMP domain; Region: HAMP; pfam00672 111781003114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003115 dimer interface [polypeptide binding]; other site 111781003116 phosphorylation site [posttranslational modification] 111781003117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003118 ATP binding site [chemical binding]; other site 111781003119 Mg2+ binding site [ion binding]; other site 111781003120 G-X-G motif; other site 111781003121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781003122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003123 active site 111781003124 phosphorylation site [posttranslational modification] 111781003125 intermolecular recognition site; other site 111781003126 dimerization interface [polypeptide binding]; other site 111781003127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781003128 DNA binding site [nucleotide binding] 111781003129 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 111781003130 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 111781003131 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 111781003132 nudix motif; other site 111781003133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781003134 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 111781003135 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781003136 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 111781003137 nitrite reductase subunit NirD; Provisional; Region: PRK14989 111781003138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 111781003139 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 111781003140 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 111781003141 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 111781003142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 111781003143 Walker A/P-loop; other site 111781003144 ATP binding site [chemical binding]; other site 111781003145 Q-loop/lid; other site 111781003146 ABC transporter signature motif; other site 111781003147 Walker B; other site 111781003148 D-loop; other site 111781003149 H-loop/switch region; other site 111781003150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 111781003151 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 111781003152 Walker A/P-loop; other site 111781003153 ATP binding site [chemical binding]; other site 111781003154 Q-loop/lid; other site 111781003155 ABC transporter signature motif; other site 111781003156 Walker B; other site 111781003157 D-loop; other site 111781003158 H-loop/switch region; other site 111781003159 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 111781003160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781003161 Homeodomain-like domain; Region: HTH_32; pfam13565 111781003162 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781003163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781003164 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 111781003165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781003166 Walker A motif; other site 111781003167 ATP binding site [chemical binding]; other site 111781003168 Walker B motif; other site 111781003169 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 111781003170 RxxxH motif; other site 111781003171 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 111781003172 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 111781003173 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 111781003174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781003175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781003176 Coenzyme A binding pocket [chemical binding]; other site 111781003177 GUN4-like; Region: GUN4; pfam05419 111781003178 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 111781003179 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 111781003180 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 111781003181 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781003182 cyclase homology domain; Region: CHD; cd07302 111781003183 nucleotidyl binding site; other site 111781003184 metal binding site [ion binding]; metal-binding site 111781003185 dimer interface [polypeptide binding]; other site 111781003186 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 111781003187 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 111781003188 catalytic residues [active] 111781003189 Gram-negative bacterial tonB protein; Region: TonB; cl10048 111781003190 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 111781003191 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 111781003192 putative ribose interaction site [chemical binding]; other site 111781003193 putative ADP binding site [chemical binding]; other site 111781003194 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 111781003195 multifunctional aminopeptidase A; Provisional; Region: PRK00913 111781003196 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 111781003197 interface (dimer of trimers) [polypeptide binding]; other site 111781003198 Substrate-binding/catalytic site; other site 111781003199 Zn-binding sites [ion binding]; other site 111781003200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781003201 Homeodomain-like domain; Region: HTH_32; pfam13565 111781003202 Winged helix-turn helix; Region: HTH_33; pfam13592 111781003203 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781003204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781003205 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 111781003206 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 111781003207 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 111781003208 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 111781003209 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 111781003210 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 111781003211 active site residue [active] 111781003212 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 111781003213 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 111781003214 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 111781003215 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 111781003216 active site 111781003217 substrate binding site [chemical binding]; other site 111781003218 metal binding site [ion binding]; metal-binding site 111781003219 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 111781003220 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 111781003221 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 111781003222 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 111781003223 enolase; Provisional; Region: eno; PRK00077 111781003224 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 111781003225 dimer interface [polypeptide binding]; other site 111781003226 metal binding site [ion binding]; metal-binding site 111781003227 substrate binding pocket [chemical binding]; other site 111781003228 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 111781003229 Stage II sporulation protein; Region: SpoIID; pfam08486 111781003230 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 111781003231 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 111781003232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003233 ATP binding site [chemical binding]; other site 111781003234 Mg2+ binding site [ion binding]; other site 111781003235 G-X-G motif; other site 111781003236 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 111781003237 Response regulator receiver domain; Region: Response_reg; pfam00072 111781003238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003239 active site 111781003240 phosphorylation site [posttranslational modification] 111781003241 intermolecular recognition site; other site 111781003242 dimerization interface [polypeptide binding]; other site 111781003243 Response regulator receiver domain; Region: Response_reg; pfam00072 111781003244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003245 active site 111781003246 phosphorylation site [posttranslational modification] 111781003247 intermolecular recognition site; other site 111781003248 dimerization interface [polypeptide binding]; other site 111781003249 hypothetical protein; Validated; Region: PRK00110 111781003250 GAF domain; Region: GAF; pfam01590 111781003251 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781003252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003254 dimer interface [polypeptide binding]; other site 111781003255 phosphorylation site [posttranslational modification] 111781003256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003257 ATP binding site [chemical binding]; other site 111781003258 Mg2+ binding site [ion binding]; other site 111781003259 G-X-G motif; other site 111781003260 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 111781003261 diaminopimelate epimerase; Region: PLN02536 111781003262 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 111781003263 Sm and related proteins; Region: Sm_like; cl00259 111781003264 heptamer interface [polypeptide binding]; other site 111781003265 Sm1 motif; other site 111781003266 hexamer interface [polypeptide binding]; other site 111781003267 RNA binding site [nucleotide binding]; other site 111781003268 Sm2 motif; other site 111781003269 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 111781003270 Peptidase family M23; Region: Peptidase_M23; pfam01551 111781003271 Late competence development protein ComFB; Region: ComFB; pfam10719 111781003272 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 111781003273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781003274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781003275 DNA binding residues [nucleotide binding] 111781003276 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 111781003277 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 111781003278 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781003279 pteridine reductase; Provisional; Region: PRK09135 111781003280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781003281 NAD(P) binding site [chemical binding]; other site 111781003282 active site 111781003283 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 111781003284 homooctamer interface [polypeptide binding]; other site 111781003285 active site 111781003286 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 111781003287 catalytic center binding site [active] 111781003288 ATP binding site [chemical binding]; other site 111781003289 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781003290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781003291 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781003292 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781003293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781003294 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 111781003295 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 111781003296 catalytic residues [active] 111781003297 Recombinase; Region: Recombinase; pfam07508 111781003298 FOG: CBS domain [General function prediction only]; Region: COG0517 111781003299 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781003300 FOG: CBS domain [General function prediction only]; Region: COG0517 111781003301 FOG: CBS domain [General function prediction only]; Region: COG0517 111781003302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 111781003303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781003304 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781003305 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 111781003306 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 111781003307 putative metal binding site; other site 111781003308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003309 binding surface 111781003310 TPR repeat; Region: TPR_11; pfam13414 111781003311 TPR motif; other site 111781003312 TPR repeat; Region: TPR_11; pfam13414 111781003313 TPR repeat; Region: TPR_11; pfam13414 111781003314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003315 binding surface 111781003316 TPR motif; other site 111781003317 light-harvesting-like protein 3; Provisional; Region: PLN00014 111781003318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781003319 carotene isomerase; Region: carot_isom; TIGR02730 111781003320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781003321 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781003322 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 111781003323 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 111781003324 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 111781003325 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 111781003326 nucleotide binding pocket [chemical binding]; other site 111781003327 K-X-D-G motif; other site 111781003328 catalytic site [active] 111781003329 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 111781003330 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 111781003331 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 111781003332 Dimer interface [polypeptide binding]; other site 111781003333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003334 binding surface 111781003335 TPR motif; other site 111781003336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003337 TPR motif; other site 111781003338 TPR repeat; Region: TPR_11; pfam13414 111781003339 binding surface 111781003340 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 111781003341 Clp amino terminal domain; Region: Clp_N; pfam02861 111781003342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781003343 Walker A motif; other site 111781003344 ATP binding site [chemical binding]; other site 111781003345 Walker B motif; other site 111781003346 arginine finger; other site 111781003347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781003348 Walker A motif; other site 111781003349 ATP binding site [chemical binding]; other site 111781003350 Walker B motif; other site 111781003351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 111781003352 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 111781003353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781003354 putative active site [active] 111781003355 heme pocket [chemical binding]; other site 111781003356 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781003357 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781003358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003360 dimer interface [polypeptide binding]; other site 111781003361 phosphorylation site [posttranslational modification] 111781003362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003363 ATP binding site [chemical binding]; other site 111781003364 Mg2+ binding site [ion binding]; other site 111781003365 G-X-G motif; other site 111781003366 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 111781003367 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 111781003368 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 111781003369 dimerization interface [polypeptide binding]; other site 111781003370 active site 111781003371 recombinase A; Provisional; Region: recA; PRK09354 111781003372 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 111781003373 hexamer interface [polypeptide binding]; other site 111781003374 Walker A motif; other site 111781003375 ATP binding site [chemical binding]; other site 111781003376 Walker B motif; other site 111781003377 TPR repeat; Region: TPR_11; pfam13414 111781003378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003379 binding surface 111781003380 TPR motif; other site 111781003381 TPR repeat; Region: TPR_11; pfam13414 111781003382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003383 binding surface 111781003384 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781003385 TPR motif; other site 111781003386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003387 binding surface 111781003388 TPR motif; other site 111781003389 TPR repeat; Region: TPR_11; pfam13414 111781003390 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 111781003391 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 111781003392 active site 111781003393 catalytic tetrad [active] 111781003394 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 111781003395 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 111781003396 putative active site [active] 111781003397 putative dimer interface [polypeptide binding]; other site 111781003398 DinB family; Region: DinB; cl17821 111781003399 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 111781003400 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781003401 Peptidase family S48; Region: Peptidase_S48; cl11616 111781003402 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 111781003403 active site flap/lid [active] 111781003404 nucleophilic elbow; other site 111781003405 catalytic triad [active] 111781003406 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 111781003407 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 111781003408 dimer interface [polypeptide binding]; other site 111781003409 anticodon binding site; other site 111781003410 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 111781003411 homodimer interface [polypeptide binding]; other site 111781003412 motif 1; other site 111781003413 active site 111781003414 motif 2; other site 111781003415 GAD domain; Region: GAD; pfam02938 111781003416 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 111781003417 motif 3; other site 111781003418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781003419 Walker A/P-loop; other site 111781003420 ATP binding site [chemical binding]; other site 111781003421 AAA domain; Region: AAA_21; pfam13304 111781003422 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 111781003423 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 111781003424 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781003425 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 111781003426 Transposase, Mutator family; Region: Transposase_mut; pfam00872 111781003427 MULE transposase domain; Region: MULE; pfam10551 111781003428 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 111781003429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781003430 S-adenosylmethionine binding site [chemical binding]; other site 111781003431 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 111781003432 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781003433 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781003434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003436 dimer interface [polypeptide binding]; other site 111781003437 phosphorylation site [posttranslational modification] 111781003438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003439 ATP binding site [chemical binding]; other site 111781003440 Mg2+ binding site [ion binding]; other site 111781003441 G-X-G motif; other site 111781003442 Response regulator receiver domain; Region: Response_reg; pfam00072 111781003443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003444 active site 111781003445 phosphorylation site [posttranslational modification] 111781003446 intermolecular recognition site; other site 111781003447 dimerization interface [polypeptide binding]; other site 111781003448 Domain of unknown function (DUF427); Region: DUF427; pfam04248 111781003449 tellurium resistance terB-like protein; Region: terB_like; cd07177 111781003450 metal binding site [ion binding]; metal-binding site 111781003451 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 111781003452 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 111781003453 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 111781003454 MOSC domain; Region: MOSC; pfam03473 111781003455 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781003456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003457 active site 111781003458 phosphorylation site [posttranslational modification] 111781003459 intermolecular recognition site; other site 111781003460 dimerization interface [polypeptide binding]; other site 111781003461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781003462 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 111781003463 putative active site [active] 111781003464 heme pocket [chemical binding]; other site 111781003465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003466 dimer interface [polypeptide binding]; other site 111781003467 phosphorylation site [posttranslational modification] 111781003468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003469 ATP binding site [chemical binding]; other site 111781003470 Mg2+ binding site [ion binding]; other site 111781003471 G-X-G motif; other site 111781003472 Response regulator receiver domain; Region: Response_reg; pfam00072 111781003473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003474 active site 111781003475 phosphorylation site [posttranslational modification] 111781003476 intermolecular recognition site; other site 111781003477 dimerization interface [polypeptide binding]; other site 111781003478 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 111781003479 metal binding site [ion binding]; metal-binding site 111781003480 nucleotidyl binding site; other site 111781003481 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781003482 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 111781003483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781003485 dimerization interface [polypeptide binding]; other site 111781003486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003487 dimer interface [polypeptide binding]; other site 111781003488 phosphorylation site [posttranslational modification] 111781003489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003490 ATP binding site [chemical binding]; other site 111781003491 Mg2+ binding site [ion binding]; other site 111781003492 G-X-G motif; other site 111781003493 Response regulator receiver domain; Region: Response_reg; pfam00072 111781003494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003495 active site 111781003496 phosphorylation site [posttranslational modification] 111781003497 intermolecular recognition site; other site 111781003498 dimerization interface [polypeptide binding]; other site 111781003499 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 111781003500 putative binding surface; other site 111781003501 active site 111781003502 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781003503 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781003504 phosphopeptide binding site; other site 111781003505 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781003506 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781003507 CHAT domain; Region: CHAT; cl17868 111781003508 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 111781003509 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781003510 P-loop; other site 111781003511 Magnesium ion binding site [ion binding]; other site 111781003512 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781003513 Magnesium ion binding site [ion binding]; other site 111781003514 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 111781003515 tocopherol O-methyltransferase; Region: PLN02244 111781003516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781003517 S-adenosylmethionine binding site [chemical binding]; other site 111781003518 salicylate hydroxylase; Provisional; Region: PRK08163 111781003519 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 111781003520 peptide chain release factor 2; Validated; Region: prfB; PRK00578 111781003521 This domain is found in peptide chain release factors; Region: PCRF; smart00937 111781003522 RF-1 domain; Region: RF-1; pfam00472 111781003523 PRC-barrel domain; Region: PRC; pfam05239 111781003524 PRC-barrel domain; Region: PRC; pfam05239 111781003525 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781003526 Fatty acid desaturase; Region: FA_desaturase; pfam00487 111781003527 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 111781003528 putative di-iron ligands [ion binding]; other site 111781003529 Predicted kinase [General function prediction only]; Region: COG0645 111781003530 AAA domain; Region: AAA_17; pfam13207 111781003531 HEAT repeats; Region: HEAT_2; pfam13646 111781003532 HEAT repeats; Region: HEAT_2; pfam13646 111781003533 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 111781003534 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 111781003535 ligand binding site [chemical binding]; other site 111781003536 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 111781003537 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 111781003538 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781003539 PAS fold; Region: PAS_4; pfam08448 111781003540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781003541 dimer interface [polypeptide binding]; other site 111781003542 phosphorylation site [posttranslational modification] 111781003543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003544 ATP binding site [chemical binding]; other site 111781003545 Mg2+ binding site [ion binding]; other site 111781003546 G-X-G motif; other site 111781003547 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 111781003548 Type II/IV secretion system protein; Region: T2SE; pfam00437 111781003549 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 111781003550 Walker A motif; other site 111781003551 ATP binding site [chemical binding]; other site 111781003552 Walker B motif; other site 111781003553 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 111781003554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003555 ATP binding site [chemical binding]; other site 111781003556 Mg2+ binding site [ion binding]; other site 111781003557 G-X-G motif; other site 111781003558 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 111781003559 ATP binding site [chemical binding]; other site 111781003560 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 111781003561 Uncharacterized conserved protein [Function unknown]; Region: COG0062 111781003562 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 111781003563 putative substrate binding site [chemical binding]; other site 111781003564 putative ATP binding site [chemical binding]; other site 111781003565 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 111781003566 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 111781003567 putative active site [active] 111781003568 Protein of unknown function, DUF258; Region: DUF258; pfam03193 111781003569 WD domain, G-beta repeat; Region: WD40; pfam00400 111781003570 Eukaryotic translation initiation factor eIF2A; Region: eIF2A; pfam08662 111781003571 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781003572 structural tetrad; other site 111781003573 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781003574 WD40 repeats; Region: WD40; smart00320 111781003575 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781003576 structural tetrad; other site 111781003577 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 111781003578 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 111781003579 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781003580 MarR family; Region: MarR_2; pfam12802 111781003581 EamA-like transporter family; Region: EamA; pfam00892 111781003582 EamA-like transporter family; Region: EamA; cl17759 111781003583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781003584 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 111781003585 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781003586 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 111781003587 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 111781003588 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 111781003589 putative dimer interface [polypeptide binding]; other site 111781003590 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 111781003591 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003592 putative active site [active] 111781003593 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003594 putative active site [active] 111781003595 TPR repeat; Region: TPR_11; pfam13414 111781003596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003597 binding surface 111781003598 TPR motif; other site 111781003599 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 111781003600 Peptidase family U32; Region: Peptidase_U32; pfam01136 111781003601 Collagenase; Region: DUF3656; pfam12392 111781003602 Peptidase family U32; Region: Peptidase_U32; cl03113 111781003603 Tetratricopeptide repeat; Region: TPR_2; pfam07719 111781003604 binding surface 111781003605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781003606 S-adenosylmethionine binding site [chemical binding]; other site 111781003607 ScpA/B protein; Region: ScpA_ScpB; cl00598 111781003608 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 111781003609 pyruvate kinase; Provisional; Region: PRK06354 111781003610 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 111781003611 domain interfaces; other site 111781003612 active site 111781003613 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 111781003614 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 111781003615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781003616 dimer interface [polypeptide binding]; other site 111781003617 phosphorylation site [posttranslational modification] 111781003618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003619 ATP binding site [chemical binding]; other site 111781003620 G-X-G motif; other site 111781003621 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781003622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781003623 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781003624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781003625 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781003626 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781003627 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781003628 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 111781003629 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 111781003630 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 111781003631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781003632 putative substrate translocation pore; other site 111781003633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 111781003634 GAF domain; Region: GAF_2; pfam13185 111781003635 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781003636 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781003637 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781003638 PAS domain S-box; Region: sensory_box; TIGR00229 111781003639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781003640 putative active site [active] 111781003641 heme pocket [chemical binding]; other site 111781003642 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781003643 cyclase homology domain; Region: CHD; cd07302 111781003644 nucleotidyl binding site; other site 111781003645 metal binding site [ion binding]; metal-binding site 111781003646 dimer interface [polypeptide binding]; other site 111781003647 Tetratricopeptide repeat; Region: TPR_2; pfam07719 111781003648 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 111781003649 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 111781003650 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 111781003651 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 111781003652 active site 111781003653 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 111781003654 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781003655 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781003656 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 111781003657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 111781003658 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781003659 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 111781003660 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 111781003661 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 111781003662 putative active site [active] 111781003663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781003664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781003665 Walker A/P-loop; other site 111781003666 ATP binding site [chemical binding]; other site 111781003667 Q-loop/lid; other site 111781003668 ABC transporter signature motif; other site 111781003669 Walker B; other site 111781003670 D-loop; other site 111781003671 H-loop/switch region; other site 111781003672 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 111781003673 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 111781003674 active site 111781003675 zinc binding site [ion binding]; other site 111781003676 S-layer homology domain; Region: SLH; pfam00395 111781003677 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781003678 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 111781003679 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 111781003680 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 111781003681 GTP/Mg2+ binding site [chemical binding]; other site 111781003682 G4 box; other site 111781003683 G5 box; other site 111781003684 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 111781003685 G1 box; other site 111781003686 G1 box; other site 111781003687 GTP/Mg2+ binding site [chemical binding]; other site 111781003688 Switch I region; other site 111781003689 G2 box; other site 111781003690 G2 box; other site 111781003691 G3 box; other site 111781003692 G3 box; other site 111781003693 Switch II region; other site 111781003694 Switch II region; other site 111781003695 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 111781003696 active site 111781003697 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 111781003698 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 111781003699 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 111781003700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781003702 dimer interface [polypeptide binding]; other site 111781003703 phosphorylation site [posttranslational modification] 111781003704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003705 ATP binding site [chemical binding]; other site 111781003706 Mg2+ binding site [ion binding]; other site 111781003707 G-X-G motif; other site 111781003708 heat shock protein 90; Provisional; Region: PRK05218 111781003709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003710 ATP binding site [chemical binding]; other site 111781003711 Mg2+ binding site [ion binding]; other site 111781003712 G-X-G motif; other site 111781003713 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 111781003714 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 111781003715 active site 111781003716 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003717 putative active site [active] 111781003718 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 111781003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781003720 S-adenosylmethionine binding site [chemical binding]; other site 111781003721 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 111781003722 Sporulation related domain; Region: SPOR; cl10051 111781003723 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 111781003724 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 111781003725 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 111781003726 homodimer interface [polypeptide binding]; other site 111781003727 NADP binding site [chemical binding]; other site 111781003728 substrate binding site [chemical binding]; other site 111781003729 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 111781003730 CoA binding domain; Region: CoA_binding; pfam02629 111781003731 CoA-ligase; Region: Ligase_CoA; pfam00549 111781003732 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 111781003733 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 111781003734 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 111781003735 DXD motif; other site 111781003736 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 111781003737 ammonium transporter; Region: amt; TIGR00836 111781003738 PAS domain S-box; Region: sensory_box; TIGR00229 111781003739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781003740 putative active site [active] 111781003741 heme pocket [chemical binding]; other site 111781003742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781003743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781003744 metal binding site [ion binding]; metal-binding site 111781003745 active site 111781003746 I-site; other site 111781003747 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 111781003748 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 111781003749 catalytic residues [active] 111781003750 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 111781003751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781003752 Walker A/P-loop; other site 111781003753 ATP binding site [chemical binding]; other site 111781003754 Q-loop/lid; other site 111781003755 ABC transporter signature motif; other site 111781003756 Walker B; other site 111781003757 D-loop; other site 111781003758 H-loop/switch region; other site 111781003759 OstA-like protein; Region: OstA; pfam03968 111781003760 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 111781003761 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 111781003762 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781003763 C-terminal domain interface [polypeptide binding]; other site 111781003764 GSH binding site (G-site) [chemical binding]; other site 111781003765 dimer interface [polypeptide binding]; other site 111781003766 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 111781003767 N-terminal domain interface [polypeptide binding]; other site 111781003768 dimer interface [polypeptide binding]; other site 111781003769 substrate binding pocket (H-site) [chemical binding]; other site 111781003770 Predicted transcriptional regulators [Transcription]; Region: COG1733 111781003771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 111781003772 dimerization interface [polypeptide binding]; other site 111781003773 putative DNA binding site [nucleotide binding]; other site 111781003774 putative Zn2+ binding site [ion binding]; other site 111781003775 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003776 putative active site [active] 111781003777 NACHT domain; Region: NACHT; pfam05729 111781003778 AAA domain; Region: AAA_17; pfam13207 111781003779 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 111781003780 short chain dehydrogenase; Validated; Region: PRK06182 111781003781 NADP binding site [chemical binding]; other site 111781003782 active site 111781003783 steroid binding site; other site 111781003784 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 111781003785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781003786 NAD(P) binding site [chemical binding]; other site 111781003787 active site 111781003788 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 111781003789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 111781003790 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 111781003791 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 111781003792 nucleotide binding site [chemical binding]; other site 111781003793 putative NEF/HSP70 interaction site [polypeptide binding]; other site 111781003794 SBD interface [polypeptide binding]; other site 111781003795 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 111781003796 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 111781003797 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 111781003798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781003799 dimer interface [polypeptide binding]; other site 111781003800 phosphorylation site [posttranslational modification] 111781003801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003802 ATP binding site [chemical binding]; other site 111781003803 Mg2+ binding site [ion binding]; other site 111781003804 G-X-G motif; other site 111781003805 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 111781003806 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 111781003807 dimer interface [polypeptide binding]; other site 111781003808 putative functional site; other site 111781003809 putative MPT binding site; other site 111781003810 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 111781003811 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 111781003812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 111781003813 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 111781003814 NAD(P) binding site [chemical binding]; other site 111781003815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781003816 HAMP domain; Region: HAMP; pfam00672 111781003817 dimerization interface [polypeptide binding]; other site 111781003818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781003819 dimer interface [polypeptide binding]; other site 111781003820 phosphorylation site [posttranslational modification] 111781003821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781003822 ATP binding site [chemical binding]; other site 111781003823 Mg2+ binding site [ion binding]; other site 111781003824 G-X-G motif; other site 111781003825 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 111781003826 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781003827 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 111781003828 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781003829 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 111781003830 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 111781003831 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 111781003832 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781003833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781003834 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781003835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003837 binding surface 111781003838 TPR motif; other site 111781003839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003841 binding surface 111781003842 TPR motif; other site 111781003843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781003844 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 111781003845 argininosuccinate synthase; Provisional; Region: PRK13820 111781003846 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 111781003847 ANP binding site [chemical binding]; other site 111781003848 Substrate Binding Site II [chemical binding]; other site 111781003849 Substrate Binding Site I [chemical binding]; other site 111781003850 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 111781003851 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 111781003852 Part of AAA domain; Region: AAA_19; pfam13245 111781003853 Family description; Region: UvrD_C_2; pfam13538 111781003854 tellurium resistance terB-like protein; Region: terB_like; cd07177 111781003855 metal binding site [ion binding]; metal-binding site 111781003856 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 111781003857 Sporulation related domain; Region: SPOR; cl10051 111781003858 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 111781003859 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 111781003860 putative active site [active] 111781003861 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 111781003862 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 111781003863 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 111781003864 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 111781003865 NADP binding site [chemical binding]; other site 111781003866 active site 111781003867 putative substrate binding site [chemical binding]; other site 111781003868 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 111781003869 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 111781003870 homopentamer interface [polypeptide binding]; other site 111781003871 active site 111781003872 Transglycosylase; Region: Transgly; pfam00912 111781003873 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 111781003874 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 111781003875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781003876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781003877 active site 111781003878 phosphorylation site [posttranslational modification] 111781003879 intermolecular recognition site; other site 111781003880 dimerization interface [polypeptide binding]; other site 111781003881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781003882 DNA binding site [nucleotide binding] 111781003883 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 111781003884 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 111781003885 nucleotide binding site [chemical binding]; other site 111781003886 putative NEF/HSP70 interaction site [polypeptide binding]; other site 111781003887 SBD interface [polypeptide binding]; other site 111781003888 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 111781003889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 111781003890 RNA binding surface [nucleotide binding]; other site 111781003891 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 111781003892 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781003893 methionine sulfoxide reductase B; Provisional; Region: PRK00222 111781003894 SelR domain; Region: SelR; pfam01641 111781003895 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 111781003896 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 111781003897 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 111781003898 phosphopeptide binding site; other site 111781003899 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781003900 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781003901 phosphopeptide binding site; other site 111781003902 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 111781003903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 111781003904 Walker A/P-loop; other site 111781003905 ATP binding site [chemical binding]; other site 111781003906 Q-loop/lid; other site 111781003907 ABC transporter signature motif; other site 111781003908 Walker B; other site 111781003909 D-loop; other site 111781003910 H-loop/switch region; other site 111781003911 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 111781003912 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 111781003913 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 111781003914 NADH(P)-binding; Region: NAD_binding_10; pfam13460 111781003915 NAD(P) binding site [chemical binding]; other site 111781003916 putative active site [active] 111781003917 NACHT domain; Region: NACHT; pfam05729 111781003918 GUN4-like; Region: GUN4; pfam05419 111781003919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781003920 S-adenosylmethionine binding site [chemical binding]; other site 111781003921 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781003922 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781003923 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 111781003924 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781003925 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 111781003926 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781003927 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 111781003928 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 111781003929 Fasciclin domain; Region: Fasciclin; pfam02469 111781003930 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 111781003931 active site clefts [active] 111781003932 zinc binding site [ion binding]; other site 111781003933 dimer interface [polypeptide binding]; other site 111781003934 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 111781003935 Domain of unknown function (DUF897); Region: DUF897; pfam05982 111781003936 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003937 putative active site [active] 111781003938 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003939 putative active site [active] 111781003940 acetyl-CoA synthetase; Provisional; Region: PRK00174 111781003941 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 111781003942 active site 111781003943 CoA binding site [chemical binding]; other site 111781003944 acyl-activating enzyme (AAE) consensus motif; other site 111781003945 AMP binding site [chemical binding]; other site 111781003946 acetate binding site [chemical binding]; other site 111781003947 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003948 putative active site [active] 111781003949 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003950 putative active site [active] 111781003951 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 111781003952 GUN4-like; Region: GUN4; pfam05419 111781003953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003955 binding surface 111781003956 TPR motif; other site 111781003957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003959 binding surface 111781003960 TPR motif; other site 111781003961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003962 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003964 binding surface 111781003965 TPR motif; other site 111781003966 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003967 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781003969 binding surface 111781003970 TPR motif; other site 111781003971 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781003972 CHAT domain; Region: CHAT; pfam12770 111781003973 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 111781003974 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 111781003975 pheophytin binding site; other site 111781003976 chlorophyll binding site; other site 111781003977 quinone binding site; other site 111781003978 Fe binding site [ion binding]; other site 111781003979 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 111781003980 Fatty acid desaturase; Region: FA_desaturase; pfam00487 111781003981 Di-iron ligands [ion binding]; other site 111781003982 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 111781003983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781003984 FeS/SAM binding site; other site 111781003985 HemN C-terminal domain; Region: HemN_C; pfam06969 111781003986 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 111781003987 heme binding pocket [chemical binding]; other site 111781003988 heme ligand [chemical binding]; other site 111781003989 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 111781003990 diiron binding motif [ion binding]; other site 111781003991 Predicted transcriptional regulators [Transcription]; Region: COG1733 111781003992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 111781003993 dimerization interface [polypeptide binding]; other site 111781003994 putative DNA binding site [nucleotide binding]; other site 111781003995 putative Zn2+ binding site [ion binding]; other site 111781003996 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781003997 putative active site [active] 111781003998 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 111781003999 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 111781004000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781004001 ATP binding site [chemical binding]; other site 111781004002 putative Mg++ binding site [ion binding]; other site 111781004003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781004004 nucleotide binding region [chemical binding]; other site 111781004005 ATP-binding site [chemical binding]; other site 111781004006 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 111781004007 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 111781004008 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781004009 anti sigma factor interaction site; other site 111781004010 regulatory phosphorylation site [posttranslational modification]; other site 111781004011 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781004012 anti sigma factor interaction site; other site 111781004013 regulatory phosphorylation site [posttranslational modification]; other site 111781004014 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 111781004015 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781004016 flavodoxin FldA; Validated; Region: PRK09267 111781004017 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 111781004018 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 111781004019 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 111781004020 active site 111781004021 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 111781004022 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 111781004023 active site 111781004024 dimer interface [polypeptide binding]; other site 111781004025 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 111781004026 Helix-turn-helix domain; Region: HTH_18; pfam12833 111781004027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 111781004028 Cupin domain; Region: Cupin_2; pfam07883 111781004029 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 111781004030 dimer interface [polypeptide binding]; other site 111781004031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781004032 ligand binding site [chemical binding]; other site 111781004033 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 111781004034 Peptidase family M23; Region: Peptidase_M23; pfam01551 111781004035 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 111781004036 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 111781004037 Caspase domain; Region: Peptidase_C14; pfam00656 111781004038 Domain of unknown function (DUF389); Region: DUF389; pfam04087 111781004039 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 111781004040 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 111781004041 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781004042 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 111781004043 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 111781004044 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 111781004045 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 111781004046 dimerization interface [polypeptide binding]; other site 111781004047 FAD binding pocket [chemical binding]; other site 111781004048 FAD binding motif [chemical binding]; other site 111781004049 catalytic residues [active] 111781004050 NAD binding pocket [chemical binding]; other site 111781004051 phosphate binding motif [ion binding]; other site 111781004052 beta-alpha-beta structure motif; other site 111781004053 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004054 GAF domain; Region: GAF; pfam01590 111781004055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781004056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004057 active site 111781004058 phosphorylation site [posttranslational modification] 111781004059 intermolecular recognition site; other site 111781004060 dimerization interface [polypeptide binding]; other site 111781004061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781004062 DNA binding site [nucleotide binding] 111781004063 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 111781004064 XdhC Rossmann domain; Region: XdhC_C; pfam13478 111781004065 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781004066 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 111781004067 short chain dehydrogenase; Provisional; Region: PRK06197 111781004068 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 111781004069 putative NAD(P) binding site [chemical binding]; other site 111781004070 active site 111781004071 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 111781004072 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 111781004073 Ca2+ binding site [ion binding]; other site 111781004074 EF-hand domain pair; Region: EF_hand_6; pfam13833 111781004075 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 111781004076 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 111781004077 substrate binding site [chemical binding]; other site 111781004078 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 111781004079 substrate binding site [chemical binding]; other site 111781004080 ligand binding site [chemical binding]; other site 111781004081 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 111781004082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781004083 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 111781004084 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781004085 AIR carboxylase; Region: AIRC; pfam00731 111781004086 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 111781004087 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 111781004088 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 111781004089 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 111781004090 Proline dehydrogenase; Region: Pro_dh; pfam01619 111781004091 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 111781004092 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 111781004093 Glutamate binding site [chemical binding]; other site 111781004094 homodimer interface [polypeptide binding]; other site 111781004095 NAD binding site [chemical binding]; other site 111781004096 catalytic residues [active] 111781004097 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 111781004098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781004099 Homeodomain-like domain; Region: HTH_32; pfam13565 111781004100 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781004101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781004102 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 111781004103 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 111781004104 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 111781004105 Catalytic NodB homology domain of uncharacterized chitin deacetylases and hypothetical proteins; Region: CE4_NodB_like_2; cd10958 111781004106 NodB motif; other site 111781004107 putative active site [active] 111781004108 putative catalytic site [active] 111781004109 PAS fold; Region: PAS_3; pfam08447 111781004110 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 111781004111 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781004112 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781004113 metal binding site [ion binding]; metal-binding site 111781004114 active site 111781004115 I-site; other site 111781004116 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781004117 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781004118 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781004119 ligand binding site [chemical binding]; other site 111781004120 flexible hinge region; other site 111781004121 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 111781004122 heme-binding site [chemical binding]; other site 111781004123 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 111781004124 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781004125 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004126 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004127 TPR repeat; Region: TPR_11; pfam13414 111781004128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004129 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 111781004130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781004131 Walker A/P-loop; other site 111781004132 ATP binding site [chemical binding]; other site 111781004133 Q-loop/lid; other site 111781004134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781004135 ABC transporter signature motif; other site 111781004136 Walker B; other site 111781004137 D-loop; other site 111781004138 H-loop/switch region; other site 111781004139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781004140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004141 ATP binding site [chemical binding]; other site 111781004142 Mg2+ binding site [ion binding]; other site 111781004143 G-X-G motif; other site 111781004144 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 111781004145 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 111781004146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 111781004147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004148 active site 111781004149 phosphorylation site [posttranslational modification] 111781004150 intermolecular recognition site; other site 111781004151 dimerization interface [polypeptide binding]; other site 111781004152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781004153 DNA binding residues [nucleotide binding] 111781004154 dimerization interface [polypeptide binding]; other site 111781004155 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781004156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004157 active site 111781004158 phosphorylation site [posttranslational modification] 111781004159 intermolecular recognition site; other site 111781004160 dimerization interface [polypeptide binding]; other site 111781004161 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004162 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004163 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 111781004164 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 111781004165 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 111781004166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 111781004167 ATP binding site [chemical binding]; other site 111781004168 Mg2+ binding site [ion binding]; other site 111781004169 G-X-G motif; other site 111781004170 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 111781004171 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 111781004172 elongation factor Ts; Reviewed; Region: tsf; PRK12332 111781004173 UBA/TS-N domain; Region: UBA; pfam00627 111781004174 Elongation factor TS; Region: EF_TS; pfam00889 111781004175 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 111781004176 rRNA interaction site [nucleotide binding]; other site 111781004177 S8 interaction site; other site 111781004178 putative laminin-1 binding site; other site 111781004179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781004180 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781004181 S-adenosylmethionine binding site [chemical binding]; other site 111781004182 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 111781004183 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 111781004184 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 111781004185 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 111781004186 Substrate binding site; other site 111781004187 Protein kinase domain; Region: Pkinase; pfam00069 111781004188 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781004189 active site 111781004190 ATP binding site [chemical binding]; other site 111781004191 substrate binding site [chemical binding]; other site 111781004192 activation loop (A-loop); other site 111781004193 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 111781004194 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 111781004195 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 111781004196 DNA binding residues [nucleotide binding] 111781004197 dimer interface [polypeptide binding]; other site 111781004198 metal binding site [ion binding]; metal-binding site 111781004199 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 111781004200 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 111781004201 active site 111781004202 intersubunit interface [polypeptide binding]; other site 111781004203 catalytic residue [active] 111781004204 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 111781004205 Rrf2 family protein; Region: rrf2_super; TIGR00738 111781004206 Transcriptional regulator; Region: Rrf2; cl17282 111781004207 Uncharacterized conserved protein [Function unknown]; Region: COG3791 111781004208 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 111781004209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 111781004210 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 111781004211 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 111781004212 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 111781004213 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781004214 Ligand Binding Site [chemical binding]; other site 111781004215 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 111781004216 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 111781004217 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 111781004218 MgtE intracellular N domain; Region: MgtE_N; smart00924 111781004219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 111781004220 Divalent cation transporter; Region: MgtE; pfam01769 111781004221 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781004222 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781004223 structural tetrad; other site 111781004224 CAAX protease self-immunity; Region: Abi; pfam02517 111781004225 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781004226 CHASE2 domain; Region: CHASE2; pfam05226 111781004227 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781004228 cyclase homology domain; Region: CHD; cd07302 111781004229 nucleotidyl binding site; other site 111781004230 metal binding site [ion binding]; metal-binding site 111781004231 dimer interface [polypeptide binding]; other site 111781004232 FecR protein; Region: FecR; pfam04773 111781004233 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 111781004234 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 111781004235 ligand binding site [chemical binding]; other site 111781004236 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 111781004237 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 111781004238 active site 111781004239 Zn binding site [ion binding]; other site 111781004240 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781004241 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781004242 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781004243 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781004244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781004245 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781004246 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781004247 CHASE2 domain; Region: CHASE2; pfam05226 111781004248 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781004249 cyclase homology domain; Region: CHD; cd07302 111781004250 nucleotidyl binding site; other site 111781004251 metal binding site [ion binding]; metal-binding site 111781004252 dimer interface [polypeptide binding]; other site 111781004253 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 111781004254 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 111781004255 PYR/PP interface [polypeptide binding]; other site 111781004256 dimer interface [polypeptide binding]; other site 111781004257 TPP binding site [chemical binding]; other site 111781004258 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 111781004259 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 111781004260 TPP-binding site [chemical binding]; other site 111781004261 dimer interface [polypeptide binding]; other site 111781004262 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 111781004263 DNA photolyase; Region: DNA_photolyase; pfam00875 111781004264 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781004265 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 111781004266 active site 111781004267 metal binding site [ion binding]; metal-binding site 111781004268 Uncharacterized conserved protein [Function unknown]; Region: COG0397 111781004269 hypothetical protein; Validated; Region: PRK00029 111781004270 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 111781004271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 111781004272 RNA binding surface [nucleotide binding]; other site 111781004273 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 111781004274 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 111781004275 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 111781004276 P loop; other site 111781004277 GTP binding site [chemical binding]; other site 111781004278 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 111781004279 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 111781004280 active site 111781004281 Zn binding site [ion binding]; other site 111781004282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 111781004283 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 111781004284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781004285 Coenzyme A binding pocket [chemical binding]; other site 111781004286 adenylate kinase; Reviewed; Region: adk; PRK00279 111781004287 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 111781004288 AMP-binding site [chemical binding]; other site 111781004289 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 111781004290 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 111781004291 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 111781004292 active site 111781004293 Zn binding site [ion binding]; other site 111781004294 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 111781004295 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 111781004296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781004297 S-adenosylmethionine binding site [chemical binding]; other site 111781004298 TPR repeat; Region: TPR_11; pfam13414 111781004299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004300 binding surface 111781004301 TPR motif; other site 111781004302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781004303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781004304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781004305 Walker A/P-loop; other site 111781004306 ATP binding site [chemical binding]; other site 111781004307 Q-loop/lid; other site 111781004308 ABC transporter signature motif; other site 111781004309 Walker B; other site 111781004310 D-loop; other site 111781004311 H-loop/switch region; other site 111781004312 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781004313 phosphopeptide binding site; other site 111781004314 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781004315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781004316 NAD(P) binding site [chemical binding]; other site 111781004317 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 111781004318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781004319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781004320 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 111781004321 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781004322 cobalamin synthase; Reviewed; Region: cobS; PRK00235 111781004323 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 111781004324 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 111781004325 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781004326 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 111781004327 putative C-terminal domain interface [polypeptide binding]; other site 111781004328 putative GSH binding site (G-site) [chemical binding]; other site 111781004329 putative dimer interface [polypeptide binding]; other site 111781004330 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 111781004331 N-terminal domain interface [polypeptide binding]; other site 111781004332 dimer interface [polypeptide binding]; other site 111781004333 substrate binding pocket (H-site) [chemical binding]; other site 111781004334 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781004335 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781004336 active site 111781004337 ATP binding site [chemical binding]; other site 111781004338 substrate binding site [chemical binding]; other site 111781004339 activation loop (A-loop); other site 111781004340 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004341 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781004342 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004343 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004344 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 111781004345 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 111781004346 putative tRNA-binding site [nucleotide binding]; other site 111781004347 B3/4 domain; Region: B3_4; pfam03483 111781004348 tRNA synthetase B5 domain; Region: B5; smart00874 111781004349 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 111781004350 dimer interface [polypeptide binding]; other site 111781004351 motif 1; other site 111781004352 motif 3; other site 111781004353 motif 2; other site 111781004354 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 111781004355 MerC mercury resistance protein; Region: MerC; cl03934 111781004356 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 111781004357 Acylphosphatase; Region: Acylphosphatase; cl00551 111781004358 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 111781004359 Ycf46; Provisional; Region: ycf46; CHL00195 111781004360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781004361 Walker A motif; other site 111781004362 ATP binding site [chemical binding]; other site 111781004363 Walker B motif; other site 111781004364 arginine finger; other site 111781004365 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 111781004366 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 111781004367 cofactor binding site; other site 111781004368 DNA binding site [nucleotide binding] 111781004369 substrate interaction site [chemical binding]; other site 111781004370 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 111781004371 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 111781004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004373 ATP binding site [chemical binding]; other site 111781004374 Mg2+ binding site [ion binding]; other site 111781004375 G-X-G motif; other site 111781004376 lipoyl synthase; Provisional; Region: PRK05481 111781004377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781004378 FeS/SAM binding site; other site 111781004379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 111781004380 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 111781004381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781004382 catalytic residue [active] 111781004383 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 111781004384 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 111781004385 homodimer interface [polypeptide binding]; other site 111781004386 oligonucleotide binding site [chemical binding]; other site 111781004387 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 111781004388 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 111781004389 homodimer interface [polypeptide binding]; other site 111781004390 metal binding site [ion binding]; metal-binding site 111781004391 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 111781004392 homodimer interface [polypeptide binding]; other site 111781004393 active site 111781004394 putative chemical substrate binding site [chemical binding]; other site 111781004395 metal binding site [ion binding]; metal-binding site 111781004396 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 111781004397 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 111781004398 alpha subunit interface [polypeptide binding]; other site 111781004399 TPP binding site [chemical binding]; other site 111781004400 heterodimer interface [polypeptide binding]; other site 111781004401 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 111781004402 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 111781004403 protein-export membrane protein SecD; Region: secD; TIGR01129 111781004404 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 111781004405 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 111781004406 Protein export membrane protein; Region: SecD_SecF; pfam02355 111781004407 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004408 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004409 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 111781004410 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781004411 DNA binding residues [nucleotide binding] 111781004412 dimerization interface [polypeptide binding]; other site 111781004413 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 111781004414 substrate binding site [chemical binding]; other site 111781004415 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 111781004416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 111781004417 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781004418 putative active site [active] 111781004419 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 111781004420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 111781004421 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 111781004422 Predicted amidohydrolase [General function prediction only]; Region: COG0388 111781004423 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 111781004424 putative active site [active] 111781004425 catalytic triad [active] 111781004426 putative dimer interface [polypeptide binding]; other site 111781004427 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 111781004428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781004429 FeS/SAM binding site; other site 111781004430 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 111781004431 Coenzyme A binding pocket [chemical binding]; other site 111781004432 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 111781004433 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 111781004434 dimerization interface [polypeptide binding]; other site 111781004435 putative ATP binding site [chemical binding]; other site 111781004436 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 111781004437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781004438 active site 111781004439 ATP binding site [chemical binding]; other site 111781004440 substrate binding site [chemical binding]; other site 111781004441 activation loop (A-loop); other site 111781004442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781004443 AAA domain; Region: AAA_22; pfam13401 111781004444 Iron permease FTR1 family; Region: FTR1; cl00475 111781004445 Ycf46; Provisional; Region: ycf46; CHL00195 111781004446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781004447 Walker A motif; other site 111781004448 ATP binding site [chemical binding]; other site 111781004449 Walker B motif; other site 111781004450 arginine finger; other site 111781004451 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 111781004452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781004453 S-adenosylmethionine binding site [chemical binding]; other site 111781004454 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 111781004455 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 111781004456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781004457 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 111781004458 Walker A motif; other site 111781004459 ATP binding site [chemical binding]; other site 111781004460 Walker B motif; other site 111781004461 HEAT repeats; Region: HEAT_2; pfam13646 111781004462 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 111781004463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781004464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781004465 DNA binding residues [nucleotide binding] 111781004466 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781004467 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 111781004468 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 111781004469 N-terminal domain interface [polypeptide binding]; other site 111781004470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781004471 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781004472 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781004473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781004474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781004475 Homeodomain-like domain; Region: HTH_32; pfam13565 111781004476 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781004477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781004478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781004479 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781004480 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781004481 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781004482 CHAT domain; Region: CHAT; cl17868 111781004483 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781004484 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781004485 Right handed beta helix region; Region: Beta_helix; pfam13229 111781004486 CHAT domain; Region: CHAT; cl17868 111781004487 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781004488 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781004489 CHAT domain; Region: CHAT; cl17868 111781004490 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 111781004491 putative active site [active] 111781004492 dimerization interface [polypeptide binding]; other site 111781004493 putative tRNAtyr binding site [nucleotide binding]; other site 111781004494 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 111781004495 Uncharacterized conserved protein [Function unknown]; Region: COG3791 111781004496 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781004497 putative active site [active] 111781004498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781004499 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781004500 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781004501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781004502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781004503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781004504 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 111781004505 EamA-like transporter family; Region: EamA; pfam00892 111781004506 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 111781004507 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 111781004508 active site flap/lid [active] 111781004509 nucleophilic elbow; other site 111781004510 catalytic triad [active] 111781004511 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 111781004512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781004513 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 111781004514 Coenzyme A binding pocket [chemical binding]; other site 111781004515 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 111781004516 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 111781004517 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 111781004518 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 111781004519 dimerization interface [polypeptide binding]; other site 111781004520 ATP binding site [chemical binding]; other site 111781004521 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 111781004522 dimerization interface [polypeptide binding]; other site 111781004523 ATP binding site [chemical binding]; other site 111781004524 Cache domain; Region: Cache_1; pfam02743 111781004525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781004526 dimerization interface [polypeptide binding]; other site 111781004527 PAS domain S-box; Region: sensory_box; TIGR00229 111781004528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781004529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781004530 metal binding site [ion binding]; metal-binding site 111781004531 active site 111781004532 I-site; other site 111781004533 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781004534 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 111781004535 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 111781004536 ligand binding site [chemical binding]; other site 111781004537 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 111781004538 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 111781004539 ligand binding site [chemical binding]; other site 111781004540 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 111781004541 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 111781004542 generic binding surface II; other site 111781004543 ssDNA binding site; other site 111781004544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781004545 ATP binding site [chemical binding]; other site 111781004546 putative Mg++ binding site [ion binding]; other site 111781004547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781004548 nucleotide binding region [chemical binding]; other site 111781004549 ATP-binding site [chemical binding]; other site 111781004550 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781004551 putative active site [active] 111781004552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781004553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781004554 Walker A/P-loop; other site 111781004555 ATP binding site [chemical binding]; other site 111781004556 Q-loop/lid; other site 111781004557 ABC transporter signature motif; other site 111781004558 Walker B; other site 111781004559 D-loop; other site 111781004560 H-loop/switch region; other site 111781004561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781004562 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 111781004563 Walker A motif; other site 111781004564 ATP binding site [chemical binding]; other site 111781004565 Walker B motif; other site 111781004566 arginine finger; other site 111781004567 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781004568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004570 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 111781004571 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 111781004572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004573 PAS domain; Region: PAS_9; pfam13426 111781004574 putative active site [active] 111781004575 heme pocket [chemical binding]; other site 111781004576 PAS domain S-box; Region: sensory_box; TIGR00229 111781004577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004578 putative active site [active] 111781004579 heme pocket [chemical binding]; other site 111781004580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004581 PAS fold; Region: PAS_3; pfam08447 111781004582 putative active site [active] 111781004583 heme pocket [chemical binding]; other site 111781004584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004585 PAS fold; Region: PAS_3; pfam08447 111781004586 putative active site [active] 111781004587 heme pocket [chemical binding]; other site 111781004588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004589 PAS fold; Region: PAS_3; pfam08447 111781004590 putative active site [active] 111781004591 heme pocket [chemical binding]; other site 111781004592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004593 PAS fold; Region: PAS_3; pfam08447 111781004594 putative active site [active] 111781004595 heme pocket [chemical binding]; other site 111781004596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004597 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 111781004598 putative active site [active] 111781004599 heme pocket [chemical binding]; other site 111781004600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004601 putative active site [active] 111781004602 heme pocket [chemical binding]; other site 111781004603 PAS domain S-box; Region: sensory_box; TIGR00229 111781004604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004605 putative active site [active] 111781004606 heme pocket [chemical binding]; other site 111781004607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004608 PAS fold; Region: PAS_3; pfam08447 111781004609 putative active site [active] 111781004610 heme pocket [chemical binding]; other site 111781004611 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781004613 dimer interface [polypeptide binding]; other site 111781004614 phosphorylation site [posttranslational modification] 111781004615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004616 ATP binding site [chemical binding]; other site 111781004617 Mg2+ binding site [ion binding]; other site 111781004618 G-X-G motif; other site 111781004619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 111781004620 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 111781004621 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 111781004622 CheB methylesterase; Region: CheB_methylest; pfam01339 111781004623 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 111781004624 PAS domain; Region: PAS_10; pfam13596 111781004625 PAS fold; Region: PAS_4; pfam08448 111781004626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004627 PAS fold; Region: PAS_3; pfam08447 111781004628 putative active site [active] 111781004629 heme pocket [chemical binding]; other site 111781004630 PAS fold; Region: PAS_4; pfam08448 111781004631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781004632 dimer interface [polypeptide binding]; other site 111781004633 phosphorylation site [posttranslational modification] 111781004634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004635 ATP binding site [chemical binding]; other site 111781004636 Mg2+ binding site [ion binding]; other site 111781004637 G-X-G motif; other site 111781004638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004639 active site 111781004640 phosphorylation site [posttranslational modification] 111781004641 intermolecular recognition site; other site 111781004642 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 111781004643 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 111781004644 HflX GTPase family; Region: HflX; cd01878 111781004645 G1 box; other site 111781004646 GTP/Mg2+ binding site [chemical binding]; other site 111781004647 Switch I region; other site 111781004648 G2 box; other site 111781004649 G3 box; other site 111781004650 Switch II region; other site 111781004651 G4 box; other site 111781004652 G5 box; other site 111781004653 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 111781004654 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 111781004655 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 111781004656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781004657 dimer interface [polypeptide binding]; other site 111781004658 phosphorylation site [posttranslational modification] 111781004659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004660 ATP binding site [chemical binding]; other site 111781004661 Mg2+ binding site [ion binding]; other site 111781004662 G-X-G motif; other site 111781004663 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 111781004664 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 111781004665 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 111781004666 active site 111781004667 chaperone protein DnaJ; Provisional; Region: PRK14299 111781004668 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781004669 HSP70 interaction site [polypeptide binding]; other site 111781004670 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 111781004671 dimer interface [polypeptide binding]; other site 111781004672 molecular chaperone DnaK; Provisional; Region: PRK13410 111781004673 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 111781004674 nucleotide binding site [chemical binding]; other site 111781004675 NEF interaction site [polypeptide binding]; other site 111781004676 SBD interface [polypeptide binding]; other site 111781004677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004678 binding surface 111781004679 TPR repeat; Region: TPR_11; pfam13414 111781004680 TPR motif; other site 111781004681 TPR repeat; Region: TPR_11; pfam13414 111781004682 TPR repeat; Region: TPR_11; pfam13414 111781004683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004684 binding surface 111781004685 TPR motif; other site 111781004686 TPR repeat; Region: TPR_11; pfam13414 111781004687 TPR repeat; Region: TPR_11; pfam13414 111781004688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004689 binding surface 111781004690 TPR motif; other site 111781004691 TPR repeat; Region: TPR_11; pfam13414 111781004692 TPR repeat; Region: TPR_11; pfam13414 111781004693 TPR repeat; Region: TPR_11; pfam13414 111781004694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004695 binding surface 111781004696 TPR motif; other site 111781004697 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781004698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004699 TPR motif; other site 111781004700 TPR repeat; Region: TPR_11; pfam13414 111781004701 binding surface 111781004702 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 111781004703 oligomeric interface; other site 111781004704 putative active site [active] 111781004705 homodimer interface [polypeptide binding]; other site 111781004706 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 111781004707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781004708 motif II; other site 111781004709 TPR repeat; Region: TPR_11; pfam13414 111781004710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004711 binding surface 111781004712 TPR motif; other site 111781004713 TPR repeat; Region: TPR_11; pfam13414 111781004714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781004715 binding surface 111781004716 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781004717 TPR motif; other site 111781004718 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 111781004719 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 111781004720 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 111781004721 dimerization interface [polypeptide binding]; other site 111781004722 domain crossover interface; other site 111781004723 redox-dependent activation switch; other site 111781004724 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781004725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781004726 phosphopeptide binding site; other site 111781004727 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 111781004728 tetracycline repressor protein TetR; Provisional; Region: PRK13756 111781004729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781004730 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 111781004731 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 111781004732 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 111781004733 putative NAD(P) binding site [chemical binding]; other site 111781004734 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 111781004735 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 111781004736 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 111781004737 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 111781004738 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781004739 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 111781004740 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 111781004741 CHASE2 domain; Region: CHASE2; cl01732 111781004742 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781004743 CHAT domain; Region: CHAT; pfam12770 111781004744 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 111781004745 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781004746 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 111781004747 putative active site [active] 111781004748 transaldolase; Provisional; Region: PRK03903 111781004749 catalytic residue [active] 111781004750 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 111781004751 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 111781004752 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 111781004753 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 111781004754 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781004755 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 111781004756 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 111781004757 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 111781004758 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 111781004759 active site 111781004760 catalytic site [active] 111781004761 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 111781004762 active site 111781004763 phosphate binding residues; other site 111781004764 catalytic residues [active] 111781004765 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 111781004766 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 111781004767 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 111781004768 Walker A/P-loop; other site 111781004769 ATP binding site [chemical binding]; other site 111781004770 Q-loop/lid; other site 111781004771 ABC transporter signature motif; other site 111781004772 Walker B; other site 111781004773 D-loop; other site 111781004774 H-loop/switch region; other site 111781004775 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 111781004776 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 111781004777 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 111781004778 SLBB domain; Region: SLBB; pfam10531 111781004779 SLBB domain; Region: SLBB; pfam10531 111781004780 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 111781004781 Chain length determinant protein; Region: Wzz; cl15801 111781004782 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 111781004783 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 111781004784 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 111781004785 Transposase; Region: HTH_Tnp_IS630; pfam01710 111781004786 Homeodomain-like domain; Region: HTH_23; pfam13384 111781004787 Winged helix-turn helix; Region: HTH_33; pfam13592 111781004788 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781004789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781004790 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 111781004791 metal ion-dependent adhesion site (MIDAS); other site 111781004792 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 111781004793 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 111781004794 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 111781004795 putative active site [active] 111781004796 catalytic site [active] 111781004797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 111781004798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781004799 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781004800 dimerization interface [polypeptide binding]; other site 111781004801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781004802 dimer interface [polypeptide binding]; other site 111781004803 phosphorylation site [posttranslational modification] 111781004804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004805 ATP binding site [chemical binding]; other site 111781004806 Mg2+ binding site [ion binding]; other site 111781004807 G-X-G motif; other site 111781004808 Response regulator receiver domain; Region: Response_reg; pfam00072 111781004809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004810 active site 111781004811 phosphorylation site [posttranslational modification] 111781004812 intermolecular recognition site; other site 111781004813 dimerization interface [polypeptide binding]; other site 111781004814 PAS fold; Region: PAS; pfam00989 111781004815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781004816 putative active site [active] 111781004817 heme pocket [chemical binding]; other site 111781004818 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781004819 cyclase homology domain; Region: CHD; cd07302 111781004820 nucleotidyl binding site; other site 111781004821 metal binding site [ion binding]; metal-binding site 111781004822 dimer interface [polypeptide binding]; other site 111781004823 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781004824 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 111781004825 non-specific DNA interactions [nucleotide binding]; other site 111781004826 DNA binding site [nucleotide binding] 111781004827 sequence specific DNA binding site [nucleotide binding]; other site 111781004828 putative cAMP binding site [chemical binding]; other site 111781004829 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 111781004830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 111781004831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781004832 dimer interface [polypeptide binding]; other site 111781004833 conserved gate region; other site 111781004834 putative PBP binding loops; other site 111781004835 ABC-ATPase subunit interface; other site 111781004836 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781004837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004838 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004839 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004840 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004841 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004842 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004843 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 111781004844 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 111781004845 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 111781004846 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 111781004847 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004848 GAF domain; Region: GAF; cl17456 111781004849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781004850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781004851 dimer interface [polypeptide binding]; other site 111781004852 phosphorylation site [posttranslational modification] 111781004853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004854 ATP binding site [chemical binding]; other site 111781004855 Mg2+ binding site [ion binding]; other site 111781004856 G-X-G motif; other site 111781004857 Response regulator receiver domain; Region: Response_reg; pfam00072 111781004858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004859 active site 111781004860 phosphorylation site [posttranslational modification] 111781004861 intermolecular recognition site; other site 111781004862 dimerization interface [polypeptide binding]; other site 111781004863 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 111781004864 glutamate racemase; Provisional; Region: PRK00865 111781004865 AMIN domain; Region: AMIN; pfam11741 111781004866 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 111781004867 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 111781004868 active site 111781004869 metal binding site [ion binding]; metal-binding site 111781004870 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 111781004871 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 111781004872 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 111781004873 active site 111781004874 catalytic triad [active] 111781004875 oxyanion hole [active] 111781004876 Exoribonuclease R [Transcription]; Region: VacB; COG0557 111781004877 RNB domain; Region: RNB; pfam00773 111781004878 ribosomal protein S18; Region: rps18; CHL00077 111781004879 ribosomal protein L33; Region: rpl33; CHL00104 111781004880 RDD family; Region: RDD; pfam06271 111781004881 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 111781004882 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 111781004883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781004884 S-adenosylmethionine binding site [chemical binding]; other site 111781004885 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 111781004886 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 111781004887 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 111781004888 MPT binding site; other site 111781004889 trimer interface [polypeptide binding]; other site 111781004890 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 111781004891 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 111781004892 phosphate binding site [ion binding]; other site 111781004893 putative substrate binding pocket [chemical binding]; other site 111781004894 dimer interface [polypeptide binding]; other site 111781004895 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 111781004896 active site 111781004897 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 111781004898 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 111781004899 substrate binding site [chemical binding]; other site 111781004900 Frequency clock protein; Region: FRQ; pfam09421 111781004901 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 111781004902 ABC1 family; Region: ABC1; cl17513 111781004903 ABC1 family; Region: ABC1; cl17513 111781004904 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 111781004905 active site 111781004906 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 111781004907 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 111781004908 FAD binding site [chemical binding]; other site 111781004909 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 111781004910 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 111781004911 active site 111781004912 HIGH motif; other site 111781004913 dimer interface [polypeptide binding]; other site 111781004914 KMSKS motif; other site 111781004915 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 111781004916 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 111781004917 TM-ABC transporter signature motif; other site 111781004918 Protein of unknown function (DUF751); Region: DUF751; pfam05421 111781004919 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 111781004920 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 111781004921 metal-binding site [ion binding] 111781004922 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 111781004923 Soluble P-type ATPase [General function prediction only]; Region: COG4087 111781004924 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 111781004925 putative binding surface; other site 111781004926 active site 111781004927 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 111781004928 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 111781004929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781004930 ATP binding site [chemical binding]; other site 111781004931 Mg2+ binding site [ion binding]; other site 111781004932 G-X-G motif; other site 111781004933 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 111781004934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004935 Response regulator receiver domain; Region: Response_reg; pfam00072 111781004936 active site 111781004937 phosphorylation site [posttranslational modification] 111781004938 intermolecular recognition site; other site 111781004939 dimerization interface [polypeptide binding]; other site 111781004940 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004941 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004942 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004943 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004944 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004945 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004946 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004947 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004949 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781004951 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781004952 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 111781004953 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 111781004954 dimer interface [polypeptide binding]; other site 111781004955 putative CheW interface [polypeptide binding]; other site 111781004956 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 111781004957 Response regulator receiver domain; Region: Response_reg; pfam00072 111781004958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004959 active site 111781004960 phosphorylation site [posttranslational modification] 111781004961 intermolecular recognition site; other site 111781004962 dimerization interface [polypeptide binding]; other site 111781004963 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781004964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781004965 active site 111781004966 phosphorylation site [posttranslational modification] 111781004967 intermolecular recognition site; other site 111781004968 dimerization interface [polypeptide binding]; other site 111781004969 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 111781004970 ligand binding site [chemical binding]; other site 111781004971 active site 111781004972 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 111781004973 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 111781004974 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 111781004975 Family of unknown function (DUF490); Region: DUF490; pfam04357 111781004976 FtsH Extracellular; Region: FtsH_ext; pfam06480 111781004977 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 111781004978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781004979 Walker A motif; other site 111781004980 ATP binding site [chemical binding]; other site 111781004981 Walker B motif; other site 111781004982 arginine finger; other site 111781004983 Peptidase family M41; Region: Peptidase_M41; pfam01434 111781004984 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 111781004985 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 111781004986 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 111781004987 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 111781004988 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 111781004989 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 111781004990 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 111781004991 peptide binding site [polypeptide binding]; other site 111781004992 dimer interface [polypeptide binding]; other site 111781004993 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 111781004994 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 111781004995 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 111781004996 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781004997 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004998 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781004999 MltA specific insert domain; Region: MltA; pfam03562 111781005000 3D domain; Region: 3D; pfam06725 111781005001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 111781005002 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 111781005003 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 111781005004 active site 111781005005 SAM binding site [chemical binding]; other site 111781005006 homodimer interface [polypeptide binding]; other site 111781005007 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 111781005008 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 111781005009 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 111781005010 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 111781005011 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 111781005012 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 111781005013 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 111781005014 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 111781005015 Peptidase family M23; Region: Peptidase_M23; pfam01551 111781005016 Dienelactone hydrolase family; Region: DLH; pfam01738 111781005017 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 111781005018 GAF domain; Region: GAF_3; pfam13492 111781005019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781005020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781005021 metal binding site [ion binding]; metal-binding site 111781005022 active site 111781005023 I-site; other site 111781005024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 111781005025 RNA binding surface [nucleotide binding]; other site 111781005026 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 111781005027 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 111781005028 metal ion-dependent adhesion site (MIDAS); other site 111781005029 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781005030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781005031 Coenzyme A binding pocket [chemical binding]; other site 111781005032 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005033 GAF domain; Region: GAF; pfam01590 111781005034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781005035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781005036 dimer interface [polypeptide binding]; other site 111781005037 phosphorylation site [posttranslational modification] 111781005038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005039 ATP binding site [chemical binding]; other site 111781005040 Mg2+ binding site [ion binding]; other site 111781005041 G-X-G motif; other site 111781005042 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 111781005043 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 111781005044 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 111781005045 DNA binding site [nucleotide binding] 111781005046 active site 111781005047 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 111781005048 NAD(P) binding pocket [chemical binding]; other site 111781005049 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 111781005050 active site 111781005051 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 111781005052 putative active site pocket [active] 111781005053 dimerization interface [polypeptide binding]; other site 111781005054 putative catalytic residue [active] 111781005055 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 111781005056 nucleotide binding site/active site [active] 111781005057 HIT family signature motif; other site 111781005058 catalytic residue [active] 111781005059 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 111781005060 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 111781005061 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 111781005062 Walker A/P-loop; other site 111781005063 ATP binding site [chemical binding]; other site 111781005064 Q-loop/lid; other site 111781005065 ABC transporter signature motif; other site 111781005066 Walker B; other site 111781005067 D-loop; other site 111781005068 H-loop/switch region; other site 111781005069 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 111781005070 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 111781005071 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 111781005072 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 111781005073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781005074 Walker A/P-loop; other site 111781005075 ATP binding site [chemical binding]; other site 111781005076 Q-loop/lid; other site 111781005077 ABC transporter signature motif; other site 111781005078 Walker B; other site 111781005079 D-loop; other site 111781005080 H-loop/switch region; other site 111781005081 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 111781005082 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 111781005083 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 111781005084 phosphoglyceromutase; Provisional; Region: PRK05434 111781005085 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 111781005086 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 111781005087 active site 111781005088 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 111781005089 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 111781005090 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 111781005091 putative active site cavity [active] 111781005092 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 111781005093 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 111781005094 active site 111781005095 substrate binding site [chemical binding]; other site 111781005096 cosubstrate binding site; other site 111781005097 catalytic site [active] 111781005098 Cupin domain; Region: Cupin_2; cl17218 111781005099 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 111781005100 ArsC family; Region: ArsC; pfam03960 111781005101 catalytic residue [active] 111781005102 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005103 GAF domain; Region: GAF; pfam01590 111781005104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005105 PAS fold; Region: PAS_3; pfam08447 111781005106 putative active site [active] 111781005107 heme pocket [chemical binding]; other site 111781005108 PAS domain S-box; Region: sensory_box; TIGR00229 111781005109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005110 putative active site [active] 111781005111 heme pocket [chemical binding]; other site 111781005112 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005113 GAF domain; Region: GAF; pfam01590 111781005114 PAS domain S-box; Region: sensory_box; TIGR00229 111781005115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005116 putative active site [active] 111781005117 heme pocket [chemical binding]; other site 111781005118 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781005119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781005120 metal binding site [ion binding]; metal-binding site 111781005121 active site 111781005122 I-site; other site 111781005123 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781005124 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005125 GAF domain; Region: GAF_3; pfam13492 111781005126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781005127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781005128 dimer interface [polypeptide binding]; other site 111781005129 phosphorylation site [posttranslational modification] 111781005130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005131 ATP binding site [chemical binding]; other site 111781005132 G-X-G motif; other site 111781005133 Protein kinase domain; Region: Pkinase; pfam00069 111781005134 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781005135 active site 111781005136 ATP binding site [chemical binding]; other site 111781005137 substrate binding site [chemical binding]; other site 111781005138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 111781005139 substrate binding site [chemical binding]; other site 111781005140 activation loop (A-loop); other site 111781005141 activation loop (A-loop); other site 111781005142 AAA ATPase domain; Region: AAA_16; pfam13191 111781005143 Predicted ATPase [General function prediction only]; Region: COG3899 111781005144 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005145 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781005146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005147 GAF domain; Region: GAF; pfam01590 111781005148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005149 ATP binding site [chemical binding]; other site 111781005150 Mg2+ binding site [ion binding]; other site 111781005151 G-X-G motif; other site 111781005152 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 111781005153 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 111781005154 NADP+ binding site [chemical binding]; other site 111781005155 RibD C-terminal domain; Region: RibD_C; cl17279 111781005156 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781005157 putative active site [active] 111781005158 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 111781005159 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 111781005160 motif 1; other site 111781005161 active site 111781005162 motif 2; other site 111781005163 motif 3; other site 111781005164 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 111781005165 Uncharacterized conserved protein [Function unknown]; Region: COG1432 111781005166 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 111781005167 putative metal binding site [ion binding]; other site 111781005168 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 111781005169 Predicted membrane protein [Function unknown]; Region: COG2259 111781005170 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 111781005171 active site 111781005172 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 111781005173 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005174 GAF domain; Region: GAF; pfam01590 111781005175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 111781005176 Zn2+ binding site [ion binding]; other site 111781005177 Mg2+ binding site [ion binding]; other site 111781005178 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 111781005179 Cytochrome c; Region: Cytochrom_C; cl11414 111781005180 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 111781005181 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 111781005182 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 111781005183 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 111781005184 Hexamer interface [polypeptide binding]; other site 111781005185 Hexagonal pore residue; other site 111781005186 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 111781005187 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 111781005188 Hexamer interface [polypeptide binding]; other site 111781005189 Hexagonal pore residue; other site 111781005190 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 111781005191 pseudouridine synthase; Region: TIGR00093 111781005192 active site 111781005193 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 111781005194 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 111781005195 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 111781005196 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 111781005197 generic binding surface I; other site 111781005198 generic binding surface II; other site 111781005199 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 111781005200 nudix motif; other site 111781005201 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 111781005202 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 111781005203 Permease; Region: Permease; cl00510 111781005204 acetolactate synthase; Reviewed; Region: PRK08322 111781005205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 111781005206 PYR/PP interface [polypeptide binding]; other site 111781005207 dimer interface [polypeptide binding]; other site 111781005208 TPP binding site [chemical binding]; other site 111781005209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 111781005210 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 111781005211 TPP-binding site [chemical binding]; other site 111781005212 dimer interface [polypeptide binding]; other site 111781005213 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 111781005214 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 111781005215 NAD(P) binding site [chemical binding]; other site 111781005216 catalytic residues [active] 111781005217 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 111781005218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781005219 active site 111781005220 motif I; other site 111781005221 motif II; other site 111781005222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781005223 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 111781005224 PAS domain; Region: PAS_9; pfam13426 111781005225 PAS fold; Region: PAS_4; pfam08448 111781005226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005227 putative active site [active] 111781005228 heme pocket [chemical binding]; other site 111781005229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005230 PAS fold; Region: PAS_3; pfam08447 111781005231 putative active site [active] 111781005232 heme pocket [chemical binding]; other site 111781005233 PAS domain S-box; Region: sensory_box; TIGR00229 111781005234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005235 putative active site [active] 111781005236 heme pocket [chemical binding]; other site 111781005237 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781005238 PAS domain S-box; Region: sensory_box; TIGR00229 111781005239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005240 putative active site [active] 111781005241 heme pocket [chemical binding]; other site 111781005242 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 111781005243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005244 putative active site [active] 111781005245 heme pocket [chemical binding]; other site 111781005246 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 111781005247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005248 putative active site [active] 111781005249 heme pocket [chemical binding]; other site 111781005250 PAS domain; Region: PAS_8; pfam13188 111781005251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781005252 dimer interface [polypeptide binding]; other site 111781005253 phosphorylation site [posttranslational modification] 111781005254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005255 ATP binding site [chemical binding]; other site 111781005256 Mg2+ binding site [ion binding]; other site 111781005257 G-X-G motif; other site 111781005258 Response regulator receiver domain; Region: Response_reg; pfam00072 111781005259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781005260 active site 111781005261 phosphorylation site [posttranslational modification] 111781005262 intermolecular recognition site; other site 111781005263 dimerization interface [polypeptide binding]; other site 111781005264 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 111781005265 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 111781005266 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 111781005267 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 111781005268 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 111781005269 C-terminal peptidase (prc); Region: prc; TIGR00225 111781005270 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 111781005271 protein binding site [polypeptide binding]; other site 111781005272 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 111781005273 Catalytic dyad [active] 111781005274 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 111781005275 active site 111781005276 metal binding site [ion binding]; metal-binding site 111781005277 interdomain interaction site; other site 111781005278 Part of AAA domain; Region: AAA_19; pfam13245 111781005279 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 111781005280 trimer interface [polypeptide binding]; other site 111781005281 dimer interface [polypeptide binding]; other site 111781005282 putative active site [active] 111781005283 2TM domain; Region: 2TM; pfam13239 111781005284 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 111781005285 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 111781005286 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 111781005287 CHAT domain; Region: CHAT; cl17868 111781005288 phosphodiesterase; Provisional; Region: PRK12704 111781005289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781005290 Homeodomain-like domain; Region: HTH_32; pfam13565 111781005291 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781005292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781005293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781005294 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781005295 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 111781005296 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 111781005297 dimerization interface [polypeptide binding]; other site 111781005298 DPS ferroxidase diiron center [ion binding]; other site 111781005299 ion pore; other site 111781005300 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 111781005301 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 111781005302 Walker A/P-loop; other site 111781005303 ATP binding site [chemical binding]; other site 111781005304 Q-loop/lid; other site 111781005305 ABC transporter signature motif; other site 111781005306 Walker B; other site 111781005307 D-loop; other site 111781005308 H-loop/switch region; other site 111781005309 TOBE domain; Region: TOBE_2; pfam08402 111781005310 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 111781005311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 111781005312 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 111781005313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781005314 dimer interface [polypeptide binding]; other site 111781005315 conserved gate region; other site 111781005316 putative PBP binding loops; other site 111781005317 ABC-ATPase subunit interface; other site 111781005318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 111781005319 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 111781005320 Protein of unknown function (DUF760); Region: DUF760; pfam05542 111781005321 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 111781005322 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 111781005323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781005324 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 111781005325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781005326 DNA binding residues [nucleotide binding] 111781005327 Integral membrane protein TerC family; Region: TerC; cl10468 111781005328 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 111781005329 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 111781005330 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 111781005331 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781005332 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781005333 active site 111781005334 ATP binding site [chemical binding]; other site 111781005335 substrate binding site [chemical binding]; other site 111781005336 activation loop (A-loop); other site 111781005337 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005338 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781005339 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781005340 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781005341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781005342 PAS domain; Region: PAS_9; pfam13426 111781005343 putative active site [active] 111781005344 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781005345 cyclase homology domain; Region: CHD; cd07302 111781005346 nucleotidyl binding site; other site 111781005347 metal binding site [ion binding]; metal-binding site 111781005348 dimer interface [polypeptide binding]; other site 111781005349 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 111781005350 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 111781005351 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 111781005352 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 111781005353 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 111781005354 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 111781005355 homodimer interface [polypeptide binding]; other site 111781005356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781005357 catalytic residue [active] 111781005358 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 111781005359 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 111781005360 UbiA prenyltransferase family; Region: UbiA; pfam01040 111781005361 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 111781005362 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 111781005363 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 111781005364 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 111781005365 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 111781005366 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 111781005367 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 111781005368 D-pathway; other site 111781005369 Putative ubiquinol binding site [chemical binding]; other site 111781005370 Low-spin heme (heme b) binding site [chemical binding]; other site 111781005371 Putative water exit pathway; other site 111781005372 Binuclear center (heme o3/CuB) [ion binding]; other site 111781005373 K-pathway; other site 111781005374 Putative proton exit pathway; other site 111781005375 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 111781005376 Subunit I/III interface [polypeptide binding]; other site 111781005377 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 111781005378 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781005379 C-terminal domain interface [polypeptide binding]; other site 111781005380 GSH binding site (G-site) [chemical binding]; other site 111781005381 dimer interface [polypeptide binding]; other site 111781005382 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 111781005383 N-terminal domain interface [polypeptide binding]; other site 111781005384 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 111781005385 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 111781005386 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 111781005387 hypothetical protein; Provisional; Region: PRK01842 111781005388 short chain dehydrogenase; Validated; Region: PRK06182 111781005389 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 111781005390 NADP binding site [chemical binding]; other site 111781005391 active site 111781005392 steroid binding site; other site 111781005393 Fic/DOC family; Region: Fic; cl00960 111781005394 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 111781005395 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 111781005396 DNA-binding site [nucleotide binding]; DNA binding site 111781005397 RNA-binding motif; other site 111781005398 MAPEG family; Region: MAPEG; cl09190 111781005399 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 111781005400 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 111781005401 DNA binding residues [nucleotide binding] 111781005402 drug binding residues [chemical binding]; other site 111781005403 dimer interface [polypeptide binding]; other site 111781005404 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 111781005405 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781005406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781005407 S-adenosylmethionine binding site [chemical binding]; other site 111781005408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781005409 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781005410 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781005411 putative active site [active] 111781005412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781005413 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781005414 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781005415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781005416 TROVE domain; Region: TROVE; pfam05731 111781005417 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781005418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781005419 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781005420 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781005421 YHS domain; Region: YHS; pfam04945 111781005422 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 111781005423 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 111781005424 hypothetical protein; Validated; Region: PRK00029 111781005425 Uncharacterized conserved protein [Function unknown]; Region: COG0397 111781005426 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 111781005427 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 111781005428 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 111781005429 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 111781005430 Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406 111781005431 putative active site [active] 111781005432 putative metal binding site [ion binding]; other site 111781005433 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 111781005434 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 111781005435 Domain of unknown function DUF59; Region: DUF59; pfam01883 111781005436 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 111781005437 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 111781005438 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 111781005439 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 111781005440 putative di-iron ligands [ion binding]; other site 111781005441 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781005442 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 111781005443 C-terminal domain interface [polypeptide binding]; other site 111781005444 GSH binding site (G-site) [chemical binding]; other site 111781005445 dimer interface [polypeptide binding]; other site 111781005446 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 111781005447 N-terminal domain interface [polypeptide binding]; other site 111781005448 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 111781005449 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 111781005450 dimer interface [polypeptide binding]; other site 111781005451 ssDNA binding site [nucleotide binding]; other site 111781005452 tetramer (dimer of dimers) interface [polypeptide binding]; other site 111781005453 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 111781005454 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781005455 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 111781005456 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 111781005457 Transposase, Mutator family; Region: Transposase_mut; pfam00872 111781005458 MULE transposase domain; Region: MULE; pfam10551 111781005459 Fe-S metabolism associated domain; Region: SufE; cl00951 111781005460 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 111781005461 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 111781005462 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 111781005463 Walker A/P-loop; other site 111781005464 ATP binding site [chemical binding]; other site 111781005465 Q-loop/lid; other site 111781005466 ABC transporter signature motif; other site 111781005467 Walker B; other site 111781005468 D-loop; other site 111781005469 H-loop/switch region; other site 111781005470 XamI restriction endonuclease; Region: RE_XamI; pfam09572 111781005471 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 111781005472 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 111781005473 GTP binding site; other site 111781005474 Peptidase family M41; Region: Peptidase_M41; pfam01434 111781005475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005476 binding surface 111781005477 TPR repeat; Region: TPR_11; pfam13414 111781005478 TPR motif; other site 111781005479 TPR repeat; Region: TPR_11; pfam13414 111781005480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005481 binding surface 111781005482 TPR motif; other site 111781005483 TPR repeat; Region: TPR_11; pfam13414 111781005484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005485 binding surface 111781005486 TPR motif; other site 111781005487 TPR repeat; Region: TPR_11; pfam13414 111781005488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005489 binding surface 111781005490 TPR motif; other site 111781005491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005492 binding surface 111781005493 TPR motif; other site 111781005494 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781005495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005496 binding surface 111781005497 TPR motif; other site 111781005498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005499 binding surface 111781005500 TPR motif; other site 111781005501 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005502 Protein of unknown function, DUF479; Region: DUF479; cl01203 111781005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 111781005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781005505 putative PBP binding loops; other site 111781005506 ABC-ATPase subunit interface; other site 111781005507 integral membrane protein MviN; Region: mviN; TIGR01695 111781005508 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 111781005509 Transposase IS200 like; Region: Y1_Tnp; pfam01797 111781005510 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 111781005511 metal ion-dependent adhesion site (MIDAS); other site 111781005512 Protein phosphatase 2C; Region: PP2C_2; pfam13672 111781005513 active site 111781005514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781005515 substrate binding site [chemical binding]; other site 111781005516 activation loop (A-loop); other site 111781005517 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 111781005518 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 111781005519 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 111781005520 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 111781005521 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 111781005522 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 111781005523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 111781005524 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 111781005525 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 111781005526 active site residue [active] 111781005527 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 111781005528 active site residue [active] 111781005529 Response regulator receiver domain; Region: Response_reg; pfam00072 111781005530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781005531 active site 111781005532 phosphorylation site [posttranslational modification] 111781005533 intermolecular recognition site; other site 111781005534 dimerization interface [polypeptide binding]; other site 111781005535 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 111781005536 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 111781005537 S-formylglutathione hydrolase; Region: PLN02442 111781005538 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 111781005539 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 111781005540 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 111781005541 substrate binding site [chemical binding]; other site 111781005542 catalytic Zn binding site [ion binding]; other site 111781005543 NAD binding site [chemical binding]; other site 111781005544 structural Zn binding site [ion binding]; other site 111781005545 dimer interface [polypeptide binding]; other site 111781005546 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 111781005547 putative FMN binding site [chemical binding]; other site 111781005548 CCC1-related family of proteins; Region: CCC1_like; cl00278 111781005549 CHAT domain; Region: CHAT; pfam12770 111781005550 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781005551 CHASE2 domain; Region: CHASE2; pfam05226 111781005552 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781005553 cyclase homology domain; Region: CHD; cd07302 111781005554 nucleotidyl binding site; other site 111781005555 metal binding site [ion binding]; metal-binding site 111781005556 dimer interface [polypeptide binding]; other site 111781005557 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 111781005558 dimer interface [polypeptide binding]; other site 111781005559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781005560 ligand binding site [chemical binding]; other site 111781005561 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 111781005562 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 111781005563 intersubunit interface [polypeptide binding]; other site 111781005564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 111781005565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781005566 active site 111781005567 metal binding site [ion binding]; metal-binding site 111781005568 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 111781005569 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 111781005570 N-terminal plug; other site 111781005571 ligand-binding site [chemical binding]; other site 111781005572 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 111781005573 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 111781005574 Walker A/P-loop; other site 111781005575 ATP binding site [chemical binding]; other site 111781005576 Q-loop/lid; other site 111781005577 ABC transporter signature motif; other site 111781005578 Walker B; other site 111781005579 D-loop; other site 111781005580 H-loop/switch region; other site 111781005581 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 111781005582 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 111781005583 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 111781005584 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 111781005585 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 111781005586 putative GSH binding site [chemical binding]; other site 111781005587 catalytic residues [active] 111781005588 BolA-like protein; Region: BolA; pfam01722 111781005589 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 111781005590 active site 111781005591 dimer interface [polypeptide binding]; other site 111781005592 putative acyl transferase; Provisional; Region: PRK10502 111781005593 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 111781005594 putative trimer interface [polypeptide binding]; other site 111781005595 putative active site [active] 111781005596 putative substrate binding site [chemical binding]; other site 111781005597 putative CoA binding site [chemical binding]; other site 111781005598 FAD binding domain; Region: FAD_binding_4; pfam01565 111781005599 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 111781005600 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 111781005601 GAF domain; Region: GAF; pfam01590 111781005602 Phytochrome region; Region: PHY; pfam00360 111781005603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781005604 dimer interface [polypeptide binding]; other site 111781005605 phosphorylation site [posttranslational modification] 111781005606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005607 ATP binding site [chemical binding]; other site 111781005608 Mg2+ binding site [ion binding]; other site 111781005609 G-X-G motif; other site 111781005610 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781005611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781005612 active site 111781005613 phosphorylation site [posttranslational modification] 111781005614 intermolecular recognition site; other site 111781005615 dimerization interface [polypeptide binding]; other site 111781005616 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 111781005617 heterotetramer interface [polypeptide binding]; other site 111781005618 active site pocket [active] 111781005619 cleavage site 111781005620 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781005621 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781005622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005624 binding surface 111781005625 TPR motif; other site 111781005626 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005628 binding surface 111781005629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005630 TPR motif; other site 111781005631 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005632 CHAT domain; Region: CHAT; pfam12770 111781005633 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781005634 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781005635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005636 binding surface 111781005637 TPR motif; other site 111781005638 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005639 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005640 CHAT domain; Region: CHAT; pfam12770 111781005641 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 111781005642 EamA-like transporter family; Region: EamA; pfam00892 111781005643 hypothetical protein; Reviewed; Region: PRK12497 111781005644 PUCC protein; Region: PUCC; pfam03209 111781005645 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781005646 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 111781005647 NAD binding site [chemical binding]; other site 111781005648 putative substrate binding site 2 [chemical binding]; other site 111781005649 putative substrate binding site 1 [chemical binding]; other site 111781005650 active site 111781005651 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 111781005652 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 111781005653 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 111781005654 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 111781005655 FtsH Extracellular; Region: FtsH_ext; pfam06480 111781005656 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 111781005657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781005658 Walker A motif; other site 111781005659 ATP binding site [chemical binding]; other site 111781005660 Walker B motif; other site 111781005661 arginine finger; other site 111781005662 Peptidase family M41; Region: Peptidase_M41; pfam01434 111781005663 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 111781005664 Cytochrome P450; Region: p450; cl12078 111781005665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 111781005666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781005667 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 111781005668 putative dimerization interface [polypeptide binding]; other site 111781005669 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 111781005670 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781005671 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 111781005672 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 111781005673 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 111781005674 homodimer interface [polypeptide binding]; other site 111781005675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781005676 catalytic residue [active] 111781005677 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 111781005678 UbiA prenyltransferase family; Region: UbiA; pfam01040 111781005679 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781005680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781005681 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781005682 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781005683 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 111781005684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781005685 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781005686 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781005687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781005688 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 111781005689 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781005690 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 111781005691 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 111781005692 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 111781005693 aromatic arch; other site 111781005694 DCoH dimer interaction site [polypeptide binding]; other site 111781005695 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 111781005696 DCoH tetramer interaction site [polypeptide binding]; other site 111781005697 substrate binding site [chemical binding]; other site 111781005698 S-layer homology domain; Region: SLH; pfam00395 111781005699 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781005700 S-layer homology domain; Region: SLH; pfam00395 111781005701 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781005702 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 111781005703 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 111781005704 NAD binding site [chemical binding]; other site 111781005705 Response regulator receiver domain; Region: Response_reg; pfam00072 111781005706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781005707 active site 111781005708 phosphorylation site [posttranslational modification] 111781005709 intermolecular recognition site; other site 111781005710 dimerization interface [polypeptide binding]; other site 111781005711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781005712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781005713 metal binding site [ion binding]; metal-binding site 111781005714 active site 111781005715 I-site; other site 111781005716 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 111781005717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 111781005718 Zn2+ binding site [ion binding]; other site 111781005719 Mg2+ binding site [ion binding]; other site 111781005720 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 111781005721 synthetase active site [active] 111781005722 NTP binding site [chemical binding]; other site 111781005723 metal binding site [ion binding]; metal-binding site 111781005724 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 111781005725 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 111781005726 adaptive-response sensory kinase; Validated; Region: PRK09303 111781005727 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 111781005728 tetramer interface [polypeptide binding]; other site 111781005729 dimer interface [polypeptide binding]; other site 111781005730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781005731 dimer interface [polypeptide binding]; other site 111781005732 phosphorylation site [posttranslational modification] 111781005733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005734 ATP binding site [chemical binding]; other site 111781005735 Mg2+ binding site [ion binding]; other site 111781005736 G-X-G motif; other site 111781005737 Uncharacterized conserved protein [Function unknown]; Region: COG1543 111781005738 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 111781005739 active site 111781005740 substrate binding site [chemical binding]; other site 111781005741 catalytic site [active] 111781005742 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 111781005743 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 111781005744 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781005745 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 111781005746 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 111781005747 Cl- selectivity filter; other site 111781005748 Cl- binding residues [ion binding]; other site 111781005749 pore gating glutamate residue; other site 111781005750 dimer interface [polypeptide binding]; other site 111781005751 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 111781005752 AIR carboxylase; Region: AIRC; smart01001 111781005753 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 111781005754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781005755 S-adenosylmethionine binding site [chemical binding]; other site 111781005756 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 111781005757 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 111781005758 ATP-grasp domain; Region: ATP-grasp; pfam02222 111781005759 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 111781005760 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 111781005761 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 111781005762 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 111781005763 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 111781005764 substrate binding site [chemical binding]; other site 111781005765 active site 111781005766 catalytic residues [active] 111781005767 heterodimer interface [polypeptide binding]; other site 111781005768 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781005769 putative active site [active] 111781005770 Caspase domain; Region: Peptidase_C14; pfam00656 111781005771 GUN4-like; Region: GUN4; pfam05419 111781005772 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 111781005773 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 111781005774 Cl- selectivity filter; other site 111781005775 Cl- binding residues [ion binding]; other site 111781005776 pore gating glutamate residue; other site 111781005777 dimer interface [polypeptide binding]; other site 111781005778 H+/Cl- coupling transport residue; other site 111781005779 FOG: CBS domain [General function prediction only]; Region: COG0517 111781005780 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 111781005781 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 111781005782 Ligand Binding Site [chemical binding]; other site 111781005783 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781005784 Ligand Binding Site [chemical binding]; other site 111781005785 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 111781005786 ATP-sulfurylase; Region: ATPS; cd00517 111781005787 active site 111781005788 HXXH motif; other site 111781005789 flexible loop; other site 111781005790 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 111781005791 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781005792 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781005793 active site 111781005794 ATP binding site [chemical binding]; other site 111781005795 substrate binding site [chemical binding]; other site 111781005796 activation loop (A-loop); other site 111781005797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005798 binding surface 111781005799 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781005800 TPR motif; other site 111781005801 TPR repeat; Region: TPR_11; pfam13414 111781005802 TPR repeat; Region: TPR_11; pfam13414 111781005803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005804 binding surface 111781005805 TPR motif; other site 111781005806 TPR repeat; Region: TPR_11; pfam13414 111781005807 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 111781005808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005809 Mg2+ binding site [ion binding]; other site 111781005810 G-X-G motif; other site 111781005811 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 111781005812 anchoring element; other site 111781005813 dimer interface [polypeptide binding]; other site 111781005814 ATP binding site [chemical binding]; other site 111781005815 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 111781005816 active site 111781005817 putative metal-binding site [ion binding]; other site 111781005818 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 111781005819 DNA primase; Validated; Region: dnaG; PRK05667 111781005820 CHC2 zinc finger; Region: zf-CHC2; pfam01807 111781005821 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 111781005822 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 111781005823 active site 111781005824 metal binding site [ion binding]; metal-binding site 111781005825 interdomain interaction site; other site 111781005826 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 111781005827 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781005828 putative active site [active] 111781005829 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 111781005830 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 111781005831 putative active site [active] 111781005832 putative metal binding residues [ion binding]; other site 111781005833 signature motif; other site 111781005834 putative dimer interface [polypeptide binding]; other site 111781005835 putative phosphate binding site [ion binding]; other site 111781005836 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 111781005837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781005838 S-adenosylmethionine binding site [chemical binding]; other site 111781005839 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 111781005840 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 111781005841 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 111781005842 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 111781005843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005844 binding surface 111781005845 TPR motif; other site 111781005846 DNA polymerase III subunit delta; Validated; Region: PRK07452 111781005847 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 111781005848 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 111781005849 Bacterial Ig-like domain; Region: Big_5; pfam13205 111781005850 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 111781005851 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781005852 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 111781005853 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 111781005854 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 111781005855 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 111781005856 putative di-iron ligands [ion binding]; other site 111781005857 ribonuclease Z; Region: RNase_Z; TIGR02651 111781005858 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 111781005859 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 111781005860 GatB domain; Region: GatB_Yqey; smart00845 111781005861 Alpha adaptin AP2, C-terminal domain; Region: Alpha_adaptin_C; pfam02296 111781005862 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 111781005863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781005864 Response regulator receiver domain; Region: Response_reg; pfam00072 111781005865 active site 111781005866 phosphorylation site [posttranslational modification] 111781005867 intermolecular recognition site; other site 111781005868 dimerization interface [polypeptide binding]; other site 111781005869 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 111781005870 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 111781005871 cobalamin binding residues [chemical binding]; other site 111781005872 putative BtuC binding residues; other site 111781005873 dimer interface [polypeptide binding]; other site 111781005874 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 111781005875 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 111781005876 Uncharacterized conserved protein [Function unknown]; Region: COG3937 111781005877 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 111781005878 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 111781005879 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781005880 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 111781005881 ketol-acid reductoisomerase; Provisional; Region: PRK05479 111781005882 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 111781005883 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 111781005884 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 111781005885 active site 111781005886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 111781005887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781005888 active site 111781005889 phosphorylation site [posttranslational modification] 111781005890 intermolecular recognition site; other site 111781005891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781005892 dimer interface [polypeptide binding]; other site 111781005893 phosphorylation site [posttranslational modification] 111781005894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781005895 ATP binding site [chemical binding]; other site 111781005896 Mg2+ binding site [ion binding]; other site 111781005897 G-X-G motif; other site 111781005898 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 111781005899 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 111781005900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781005901 catalytic residue [active] 111781005902 HAS barrel domain; Region: HAS-barrel; pfam09378 111781005903 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 111781005904 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 111781005905 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 111781005906 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 111781005907 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 111781005908 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 111781005909 catalytic residues [active] 111781005910 Predicted membrane protein [Function unknown]; Region: COG4094 111781005911 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 111781005912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781005913 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 111781005914 putative dimerization interface [polypeptide binding]; other site 111781005915 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 111781005916 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 111781005917 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 111781005918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005919 binding surface 111781005920 TPR repeat; Region: TPR_11; pfam13414 111781005921 TPR motif; other site 111781005922 TPR repeat; Region: TPR_11; pfam13414 111781005923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005924 binding surface 111781005925 TPR motif; other site 111781005926 TPR repeat; Region: TPR_11; pfam13414 111781005927 TPR repeat; Region: TPR_11; pfam13414 111781005928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005929 binding surface 111781005930 TPR motif; other site 111781005931 TPR repeat; Region: TPR_11; pfam13414 111781005932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005933 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 111781005934 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 111781005935 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 111781005936 active site 111781005937 metal binding site [ion binding]; metal-binding site 111781005938 DNA binding site [nucleotide binding] 111781005939 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 111781005940 ABC1 family; Region: ABC1; cl17513 111781005941 C-terminal peptidase (prc); Region: prc; TIGR00225 111781005942 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 111781005943 protein binding site [polypeptide binding]; other site 111781005944 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 111781005945 Catalytic dyad [active] 111781005946 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 111781005947 nudix motif; other site 111781005948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 111781005949 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 111781005950 active site 111781005951 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 111781005952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005953 binding surface 111781005954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005955 TPR motif; other site 111781005956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005960 binding surface 111781005961 TPR motif; other site 111781005962 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005963 CHAT domain; Region: CHAT; pfam12770 111781005964 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781005965 NB-ARC domain; Region: NB-ARC; pfam00931 111781005966 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005968 binding surface 111781005969 TPR motif; other site 111781005970 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005971 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005973 binding surface 111781005974 TPR motif; other site 111781005975 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781005977 binding surface 111781005978 TPR motif; other site 111781005979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781005980 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781005981 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781005982 structural tetrad; other site 111781005983 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781005984 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781005985 structural tetrad; other site 111781005986 Transcriptional regulators [Transcription]; Region: MarR; COG1846 111781005987 MarR family; Region: MarR_2; pfam12802 111781005988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781005989 NmrA-like family; Region: NmrA; pfam05368 111781005990 NAD(P) binding site [chemical binding]; other site 111781005991 active site 111781005992 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781005993 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781005994 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781005995 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781005996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781005997 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 111781005998 active site 111781005999 metal binding site [ion binding]; metal-binding site 111781006000 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 111781006001 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781006002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781006003 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781006004 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781006005 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781006006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781006007 Ectoine synthase; Region: Ectoine_synth; pfam06339 111781006008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 111781006009 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 111781006010 FtsX-like permease family; Region: FtsX; pfam02687 111781006011 FtsX-like permease family; Region: FtsX; pfam02687 111781006012 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 111781006013 nucleotide binding site/active site [active] 111781006014 HIT family signature motif; other site 111781006015 catalytic residue [active] 111781006016 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781006017 putative active site [active] 111781006018 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 111781006019 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 111781006020 Walker A/P-loop; other site 111781006021 ATP binding site [chemical binding]; other site 111781006022 Q-loop/lid; other site 111781006023 ABC transporter signature motif; other site 111781006024 Walker B; other site 111781006025 D-loop; other site 111781006026 H-loop/switch region; other site 111781006027 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 111781006028 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 111781006029 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781006030 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 111781006031 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 111781006032 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 111781006033 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 111781006034 homodecamer interface [polypeptide binding]; other site 111781006035 GTP cyclohydrolase I; Provisional; Region: PLN03044 111781006036 active site 111781006037 putative catalytic site residues [active] 111781006038 zinc binding site [ion binding]; other site 111781006039 GTP-CH-I/GFRP interaction surface; other site 111781006040 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 111781006041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781006042 Walker A motif; other site 111781006043 ATP binding site [chemical binding]; other site 111781006044 Walker B motif; other site 111781006045 arginine finger; other site 111781006046 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 111781006047 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 111781006048 active site clefts [active] 111781006049 zinc binding site [ion binding]; other site 111781006050 dimer interface [polypeptide binding]; other site 111781006051 Cupin domain; Region: Cupin_2; pfam07883 111781006052 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 111781006053 MutS domain III; Region: MutS_III; pfam05192 111781006054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781006055 Walker A/P-loop; other site 111781006056 ATP binding site [chemical binding]; other site 111781006057 Q-loop/lid; other site 111781006058 ABC transporter signature motif; other site 111781006059 Walker B; other site 111781006060 D-loop; other site 111781006061 H-loop/switch region; other site 111781006062 Smr domain; Region: Smr; pfam01713 111781006063 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 111781006064 Active_site [active] 111781006065 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781006066 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781006067 catalytic loop [active] 111781006068 iron binding site [ion binding]; other site 111781006069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781006070 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781006071 catalytic loop [active] 111781006072 iron binding site [ion binding]; other site 111781006073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 111781006074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 111781006075 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 111781006076 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 111781006077 Walker A/P-loop; other site 111781006078 ATP binding site [chemical binding]; other site 111781006079 Q-loop/lid; other site 111781006080 ABC transporter signature motif; other site 111781006081 Walker B; other site 111781006082 D-loop; other site 111781006083 H-loop/switch region; other site 111781006084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 111781006085 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 111781006086 Walker A/P-loop; other site 111781006087 ATP binding site [chemical binding]; other site 111781006088 Q-loop/lid; other site 111781006089 ABC transporter signature motif; other site 111781006090 Walker B; other site 111781006091 D-loop; other site 111781006092 H-loop/switch region; other site 111781006093 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 111781006094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781006095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781006096 DNA binding residues [nucleotide binding] 111781006097 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 111781006098 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 111781006099 Ligand Binding Site [chemical binding]; other site 111781006100 KGK domain; Region: KGK; pfam08872 111781006101 cytochrome c biogenesis protein; Region: ccsA; CHL00045 111781006102 FO synthase subunit 2; Reviewed; Region: PRK07360 111781006103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781006104 FeS/SAM binding site; other site 111781006105 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 111781006106 pyrroline-5-carboxylate reductase; Region: PLN02688 111781006107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 111781006108 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 111781006109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 111781006110 catalytic residue [active] 111781006111 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 111781006112 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 111781006113 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 111781006114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781006115 FeS/SAM binding site; other site 111781006116 TRAM domain; Region: TRAM; pfam01938 111781006117 MEKHLA domain; Region: MEKHLA; pfam08670 111781006118 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 111781006119 HD domain; Region: HD_4; pfam13328 111781006120 Protein of unknown function DUF45; Region: DUF45; pfam01863 111781006121 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 111781006122 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 111781006123 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 111781006124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781006125 motif II; other site 111781006126 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 111781006127 rod shape-determining protein MreC; Provisional; Region: PRK13922 111781006128 rod shape-determining protein MreC; Region: MreC; pfam04085 111781006129 rod shape-determining protein MreB; Provisional; Region: PRK13927 111781006130 MreB and similar proteins; Region: MreB_like; cd10225 111781006131 nucleotide binding site [chemical binding]; other site 111781006132 Mg binding site [ion binding]; other site 111781006133 putative protofilament interaction site [polypeptide binding]; other site 111781006134 RodZ interaction site [polypeptide binding]; other site 111781006135 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 111781006136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 111781006137 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 111781006138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781006139 dimer interface [polypeptide binding]; other site 111781006140 conserved gate region; other site 111781006141 putative PBP binding loops; other site 111781006142 ABC-ATPase subunit interface; other site 111781006143 GTPase CgtA; Reviewed; Region: obgE; PRK12299 111781006144 GTP1/OBG; Region: GTP1_OBG; pfam01018 111781006145 Obg GTPase; Region: Obg; cd01898 111781006146 G1 box; other site 111781006147 GTP/Mg2+ binding site [chemical binding]; other site 111781006148 Switch I region; other site 111781006149 G2 box; other site 111781006150 G3 box; other site 111781006151 Switch II region; other site 111781006152 G4 box; other site 111781006153 G5 box; other site 111781006154 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 111781006155 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 111781006156 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 111781006157 Isochorismatase family; Region: Isochorismatase; pfam00857 111781006158 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 111781006159 catalytic triad [active] 111781006160 conserved cis-peptide bond; other site 111781006161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781006162 putative active site [active] 111781006163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781006164 heme pocket [chemical binding]; other site 111781006165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781006166 dimer interface [polypeptide binding]; other site 111781006167 phosphorylation site [posttranslational modification] 111781006168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781006169 ATP binding site [chemical binding]; other site 111781006170 Mg2+ binding site [ion binding]; other site 111781006171 G-X-G motif; other site 111781006172 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 111781006173 phosphoenolpyruvate synthase; Validated; Region: PRK06241 111781006174 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 111781006175 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 111781006176 prenyltransferase; Provisional; Region: ubiA; PRK13592 111781006177 UbiA prenyltransferase family; Region: UbiA; pfam01040 111781006178 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 111781006179 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 111781006180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781006181 FeS/SAM binding site; other site 111781006182 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 111781006183 Na binding site [ion binding]; other site 111781006184 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 111781006185 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 111781006186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781006187 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 111781006188 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 111781006189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781006190 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 111781006191 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 111781006192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781006193 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 111781006194 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 111781006195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781006196 S-adenosylmethionine binding site [chemical binding]; other site 111781006197 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 111781006198 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 111781006199 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 111781006200 seryl-tRNA synthetase; Provisional; Region: PRK05431 111781006201 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 111781006202 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 111781006203 dimer interface [polypeptide binding]; other site 111781006204 active site 111781006205 motif 1; other site 111781006206 motif 2; other site 111781006207 motif 3; other site 111781006208 malate dehydrogenase; Reviewed; Region: PRK06223 111781006209 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 111781006210 NAD(P) binding site [chemical binding]; other site 111781006211 dimer interface [polypeptide binding]; other site 111781006212 tetramer (dimer of dimers) interface [polypeptide binding]; other site 111781006213 substrate binding site [chemical binding]; other site 111781006214 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 111781006215 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781006216 Protein of unknown function (DUF760); Region: DUF760; pfam05542 111781006217 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 111781006218 PAS fold; Region: PAS_3; pfam08447 111781006219 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781006220 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781006221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781006222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781006223 dimer interface [polypeptide binding]; other site 111781006224 phosphorylation site [posttranslational modification] 111781006225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781006226 ATP binding site [chemical binding]; other site 111781006227 Mg2+ binding site [ion binding]; other site 111781006228 G-X-G motif; other site 111781006229 EVE domain; Region: EVE; cl00728 111781006230 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 111781006231 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781006232 Ligand Binding Site [chemical binding]; other site 111781006233 dephospho-CoA kinase; Region: TIGR00152 111781006234 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 111781006235 CoA-binding site [chemical binding]; other site 111781006236 ATP-binding [chemical binding]; other site 111781006237 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 111781006238 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 111781006239 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 111781006240 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 111781006241 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 111781006242 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 111781006243 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781006244 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781006245 Ion channel; Region: Ion_trans_2; pfam07885 111781006246 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 111781006247 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 111781006248 Phosphoglycerate kinase; Region: PGK; pfam00162 111781006249 substrate binding site [chemical binding]; other site 111781006250 hinge regions; other site 111781006251 ADP binding site [chemical binding]; other site 111781006252 catalytic site [active] 111781006253 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781006254 Ligand Binding Site [chemical binding]; other site 111781006255 Cna protein B-type domain; Region: Cna_B; pfam05738 111781006256 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 111781006257 BON domain; Region: BON; pfam04972 111781006258 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 111781006259 ligand binding site [chemical binding]; other site 111781006260 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 111781006261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781006262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781006263 active site 111781006264 ATP binding site [chemical binding]; other site 111781006265 substrate binding site [chemical binding]; other site 111781006266 activation loop (A-loop); other site 111781006267 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006268 CHAT domain; Region: CHAT; pfam12770 111781006269 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781006270 putative active site [active] 111781006271 haemagglutination activity domain; Region: Haemagg_act; cl05436 111781006272 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781006273 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 111781006274 Methyltransferase domain; Region: Methyltransf_23; pfam13489 111781006275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781006276 S-adenosylmethionine binding site [chemical binding]; other site 111781006277 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 111781006278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781006279 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 111781006280 E3 interaction surface; other site 111781006281 lipoyl attachment site [posttranslational modification]; other site 111781006282 e3 binding domain; Region: E3_binding; pfam02817 111781006283 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 111781006284 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 111781006285 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 111781006286 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 111781006287 catalytic triad [active] 111781006288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 111781006289 FIST N domain; Region: FIST; smart00897 111781006290 FIST C domain; Region: FIST_C; pfam10442 111781006291 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 111781006292 homotrimer interaction site [polypeptide binding]; other site 111781006293 putative active site [active] 111781006294 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 111781006295 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 111781006296 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 111781006297 PsaD; Region: PsaD; pfam02531 111781006298 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 111781006299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781006300 dimer interface [polypeptide binding]; other site 111781006301 conserved gate region; other site 111781006302 putative PBP binding loops; other site 111781006303 ABC-ATPase subunit interface; other site 111781006304 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 111781006305 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 111781006306 catalytic residues [active] 111781006307 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 111781006308 EamA-like transporter family; Region: EamA; pfam00892 111781006309 EamA-like transporter family; Region: EamA; pfam00892 111781006310 Protein of function (DUF2518); Region: DUF2518; pfam10726 111781006311 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 111781006312 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 111781006313 putative active site [active] 111781006314 metal binding site [ion binding]; metal-binding site 111781006315 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781006316 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781006317 ligand binding site [chemical binding]; other site 111781006318 flexible hinge region; other site 111781006319 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 111781006320 ATP-grasp domain; Region: ATP-grasp; pfam02222 111781006321 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781006322 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781006323 ligand binding site [chemical binding]; other site 111781006324 flexible hinge region; other site 111781006325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781006326 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 111781006327 putative active site pocket [active] 111781006328 dimerization interface [polypeptide binding]; other site 111781006329 putative catalytic residue [active] 111781006330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 111781006331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781006332 active site 111781006333 phosphorylation site [posttranslational modification] 111781006334 intermolecular recognition site; other site 111781006335 dimerization interface [polypeptide binding]; other site 111781006336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781006337 DNA binding residues [nucleotide binding] 111781006338 dimerization interface [polypeptide binding]; other site 111781006339 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 111781006340 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 111781006341 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 111781006342 active site 111781006343 dimer interface [polypeptide binding]; other site 111781006344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781006345 active site 111781006346 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 111781006347 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 111781006348 FtsX-like permease family; Region: FtsX; pfam02687 111781006349 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 111781006350 SNF2 Helicase protein; Region: DUF3670; pfam12419 111781006351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781006352 ATP binding site [chemical binding]; other site 111781006353 putative Mg++ binding site [ion binding]; other site 111781006354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781006355 nucleotide binding region [chemical binding]; other site 111781006356 ATP-binding site [chemical binding]; other site 111781006357 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 111781006358 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781006359 Switch II region; other site 111781006360 G4 box; other site 111781006361 G5 box; other site 111781006362 Domain of unknown function (DUF697); Region: DUF697; pfam05128 111781006363 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 111781006364 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 111781006365 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 111781006366 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 111781006367 putative dimer interface [polypeptide binding]; other site 111781006368 N-terminal domain interface [polypeptide binding]; other site 111781006369 putative substrate binding pocket (H-site) [chemical binding]; other site 111781006370 Predicted membrane protein [Function unknown]; Region: COG3463 111781006371 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 111781006372 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 111781006373 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 111781006374 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 111781006375 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 111781006376 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 111781006377 Zn2+ binding site [ion binding]; other site 111781006378 Mg2+ binding site [ion binding]; other site 111781006379 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 111781006380 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 111781006381 proposed catalytic triad [active] 111781006382 active site nucleophile [active] 111781006383 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 111781006384 ATP-grasp domain; Region: ATP-grasp_4; cl17255 111781006385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781006386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 111781006387 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 111781006388 catalytic core [active] 111781006389 Protein of unknown function DUF86; Region: DUF86; cl01031 111781006390 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 111781006391 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 111781006392 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 111781006393 glutaminase active site [active] 111781006394 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 111781006395 dimer interface [polypeptide binding]; other site 111781006396 active site 111781006397 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 111781006398 dimer interface [polypeptide binding]; other site 111781006399 active site 111781006400 acyl-CoA synthetase; Validated; Region: PRK05850 111781006401 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 111781006402 acyl-activating enzyme (AAE) consensus motif; other site 111781006403 active site 111781006404 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 111781006405 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 111781006406 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 111781006407 substrate-cofactor binding pocket; other site 111781006408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781006409 catalytic residue [active] 111781006410 short chain dehydrogenase; Provisional; Region: PRK06181 111781006411 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 111781006412 putative NAD(P) binding site [chemical binding]; other site 111781006413 homotetramer interface [polypeptide binding]; other site 111781006414 active site 111781006415 homodimer interface [polypeptide binding]; other site 111781006416 acyl-CoA synthetase; Validated; Region: PRK05850 111781006417 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 111781006418 acyl-activating enzyme (AAE) consensus motif; other site 111781006419 active site 111781006420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781006421 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 111781006422 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 111781006423 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 111781006424 putative active site [active] 111781006425 Zn binding site [ion binding]; other site 111781006426 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781006428 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 111781006429 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 111781006430 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781006431 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781006432 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781006433 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781006434 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781006435 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781006436 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781006437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781006438 Homeodomain-like domain; Region: HTH_32; pfam13565 111781006439 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781006440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781006441 TIR domain; Region: TIR_2; pfam13676 111781006442 TIR domain; Region: TIR_2; pfam13676 111781006443 TIR domain; Region: TIR_2; pfam13676 111781006444 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781006445 CHASE2 domain; Region: CHASE2; pfam05226 111781006446 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781006447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006448 TPR motif; other site 111781006449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006450 binding surface 111781006451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006454 binding surface 111781006455 TPR motif; other site 111781006456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006458 binding surface 111781006459 TPR motif; other site 111781006460 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781006462 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 111781006463 Peptidase family M50; Region: Peptidase_M50; pfam02163 111781006464 active site 111781006465 putative substrate binding region [chemical binding]; other site 111781006466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 111781006467 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 111781006468 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 111781006469 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 111781006470 putative NAD(P) binding site [chemical binding]; other site 111781006471 active site 111781006472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781006473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781006474 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781006475 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 111781006476 C-terminal domain interface [polypeptide binding]; other site 111781006477 GSH binding site (G-site) [chemical binding]; other site 111781006478 dimer interface [polypeptide binding]; other site 111781006479 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 111781006480 N-terminal domain interface [polypeptide binding]; other site 111781006481 dimer interface [polypeptide binding]; other site 111781006482 substrate binding pocket (H-site) [chemical binding]; other site 111781006483 AAA ATPase domain; Region: AAA_16; pfam13191 111781006484 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 111781006485 putative active site [active] 111781006486 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 111781006487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781006488 AAA domain; Region: AAA_22; pfam13401 111781006489 Walker A motif; other site 111781006490 ATP binding site [chemical binding]; other site 111781006491 Walker B motif; other site 111781006492 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 111781006493 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 111781006494 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 111781006495 N-acetyl-D-glucosamine binding site [chemical binding]; other site 111781006496 catalytic residue [active] 111781006497 Bacterial Ig-like domain; Region: Big_5; pfam13205 111781006498 Membrane protein of unknown function; Region: DUF360; pfam04020 111781006499 hypothetical protein; Region: PHA02414 111781006500 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781006501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781006502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781006503 Walker A/P-loop; other site 111781006504 ATP binding site [chemical binding]; other site 111781006505 Q-loop/lid; other site 111781006506 ABC transporter signature motif; other site 111781006507 Walker B; other site 111781006508 D-loop; other site 111781006509 H-loop/switch region; other site 111781006510 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 111781006511 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781006512 CHASE2 domain; Region: CHASE2; pfam05226 111781006513 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781006514 cyclase homology domain; Region: CHD; cd07302 111781006515 nucleotidyl binding site; other site 111781006516 metal binding site [ion binding]; metal-binding site 111781006517 dimer interface [polypeptide binding]; other site 111781006518 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 111781006519 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 111781006520 S-layer homology domain; Region: SLH; pfam00395 111781006521 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 111781006522 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 111781006523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781006524 ABC-ATPase subunit interface; other site 111781006525 putative PBP binding loops; other site 111781006526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781006527 dimer interface [polypeptide binding]; other site 111781006528 conserved gate region; other site 111781006529 putative PBP binding loops; other site 111781006530 ABC-ATPase subunit interface; other site 111781006531 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781006532 active site 111781006533 NTP binding site [chemical binding]; other site 111781006534 metal binding triad [ion binding]; metal-binding site 111781006535 antibiotic binding site [chemical binding]; other site 111781006536 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 111781006537 L-aspartate oxidase; Provisional; Region: PRK06175 111781006538 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 111781006539 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781006540 putative active site [active] 111781006541 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 111781006542 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 111781006543 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 111781006544 substrate binding pocket [chemical binding]; other site 111781006545 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 111781006546 B12 binding site [chemical binding]; other site 111781006547 cobalt ligand [ion binding]; other site 111781006548 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 111781006549 phosphoenolpyruvate synthase; Validated; Region: PRK06464 111781006550 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 111781006551 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 111781006552 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 111781006553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781006554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781006555 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 111781006556 Coenzyme A binding pocket [chemical binding]; other site 111781006557 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781006558 putative active site [active] 111781006559 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 111781006560 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 111781006561 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781006562 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 111781006563 hypothetical protein; Provisional; Region: PRK04323 111781006564 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 111781006565 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 111781006566 catalytic site [active] 111781006567 G-X2-G-X-G-K; other site 111781006568 Clp protease; Region: CLP_protease; pfam00574 111781006569 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 111781006570 oligomer interface [polypeptide binding]; other site 111781006571 active site residues [active] 111781006572 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781006573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781006574 S-adenosylmethionine binding site [chemical binding]; other site 111781006575 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 111781006576 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 111781006577 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 111781006578 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781006579 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781006580 catalytic loop [active] 111781006581 iron binding site [ion binding]; other site 111781006582 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781006583 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781006584 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 111781006585 CHAT domain; Region: CHAT; cl17868 111781006586 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781006587 iron-sulfur cluster [ion binding]; other site 111781006588 [2Fe-2S] cluster binding site [ion binding]; other site 111781006589 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 111781006590 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 111781006591 PYR/PP interface [polypeptide binding]; other site 111781006592 dimer interface [polypeptide binding]; other site 111781006593 tetramer interface [polypeptide binding]; other site 111781006594 TPP binding site [chemical binding]; other site 111781006595 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 111781006596 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 111781006597 TPP-binding site [chemical binding]; other site 111781006598 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781006599 iron-sulfur cluster [ion binding]; other site 111781006600 [2Fe-2S] cluster binding site [ion binding]; other site 111781006601 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 111781006602 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 111781006603 active site 111781006604 FMN binding site [chemical binding]; other site 111781006605 substrate binding site [chemical binding]; other site 111781006606 3Fe-4S cluster binding site [ion binding]; other site 111781006607 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 111781006608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 111781006609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781006610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 111781006611 dimerization interface [polypeptide binding]; other site 111781006612 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781006613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781006614 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781006615 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781006616 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 111781006617 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781006618 iron-sulfur cluster [ion binding]; other site 111781006619 [2Fe-2S] cluster binding site [ion binding]; other site 111781006620 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 111781006621 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781006622 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781006623 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 111781006624 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 111781006625 inhibitor-cofactor binding pocket; inhibition site 111781006626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781006627 catalytic residue [active] 111781006628 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781006629 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781006630 catalytic loop [active] 111781006631 iron binding site [ion binding]; other site 111781006632 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 111781006633 Phycobilisome protein; Region: Phycobilisome; cl08227 111781006634 Phycobilisome protein; Region: Phycobilisome; cl08227 111781006635 HEAT repeats; Region: HEAT_2; pfam13646 111781006636 HEAT repeats; Region: HEAT_2; pfam13646 111781006637 HEAT repeats; Region: HEAT_2; pfam13646 111781006638 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 111781006639 homotrimer interaction site [polypeptide binding]; other site 111781006640 active site 111781006641 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 111781006642 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 111781006643 tandem repeat interface [polypeptide binding]; other site 111781006644 oligomer interface [polypeptide binding]; other site 111781006645 active site residues [active] 111781006646 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 111781006647 EamA-like transporter family; Region: EamA; pfam00892 111781006648 EamA-like transporter family; Region: EamA; pfam00892 111781006649 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 111781006650 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 111781006651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781006652 putative substrate translocation pore; other site 111781006653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781006654 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781006655 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781006656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781006657 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 111781006658 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 111781006659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 111781006660 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 111781006661 active site 111781006662 intersubunit interface [polypeptide binding]; other site 111781006663 catalytic residue [active] 111781006664 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 111781006665 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 111781006666 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 111781006667 ligand binding site [chemical binding]; other site 111781006668 CHAT domain; Region: CHAT; pfam12770 111781006669 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781006670 phosphopeptide binding site; other site 111781006671 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 111781006672 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 111781006673 ring oligomerisation interface [polypeptide binding]; other site 111781006674 ATP/Mg binding site [chemical binding]; other site 111781006675 stacking interactions; other site 111781006676 hinge regions; other site 111781006677 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 111781006678 TIGR03032 family protein; Region: TIGR03032 111781006679 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 111781006680 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 111781006681 feedback inhibition sensing region; other site 111781006682 homohexameric interface [polypeptide binding]; other site 111781006683 nucleotide binding site [chemical binding]; other site 111781006684 N-acetyl-L-glutamate binding site [chemical binding]; other site 111781006685 shikimate kinase; Reviewed; Region: aroK; PRK00131 111781006686 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 111781006687 ADP binding site [chemical binding]; other site 111781006688 magnesium binding site [ion binding]; other site 111781006689 putative shikimate binding site; other site 111781006690 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 111781006691 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 111781006692 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 111781006693 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 111781006694 short chain dehydrogenase; Provisional; Region: PRK12367 111781006695 NAD(P) binding site [chemical binding]; other site 111781006696 active site 111781006697 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 111781006698 FOG: CBS domain [General function prediction only]; Region: COG0517 111781006699 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781006700 FOG: CBS domain [General function prediction only]; Region: COG0517 111781006701 FOG: CBS domain [General function prediction only]; Region: COG0517 111781006702 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 111781006703 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781006704 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 111781006705 M28 Zn-Peptidases; Region: M28_like_1; cd05640 111781006706 Peptidase family M28; Region: Peptidase_M28; pfam04389 111781006707 metal binding site [ion binding]; metal-binding site 111781006708 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 111781006709 RNA/DNA hybrid binding site [nucleotide binding]; other site 111781006710 active site 111781006711 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781006712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006713 binding surface 111781006714 TPR motif; other site 111781006715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006716 binding surface 111781006717 TPR motif; other site 111781006718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006719 binding surface 111781006720 TPR motif; other site 111781006721 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 111781006722 Protein of unknown function (DUF790); Region: DUF790; pfam05626 111781006723 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 111781006724 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 111781006725 UbiA prenyltransferase family; Region: UbiA; pfam01040 111781006726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 111781006727 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 111781006728 MAPEG family; Region: MAPEG; cl09190 111781006729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781006730 Homeodomain-like domain; Region: HTH_32; pfam13565 111781006731 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781006732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781006733 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 111781006734 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 111781006735 ATP-grasp domain; Region: ATP-grasp_4; cl17255 111781006736 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 111781006737 Septum formation; Region: Septum_form; pfam13845 111781006738 YcxB-like protein; Region: YcxB; pfam14317 111781006739 Predicted ATPase [General function prediction only]; Region: COG5293 111781006740 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 111781006741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 111781006742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781006743 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781006744 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781006745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781006746 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 111781006747 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 111781006748 Ligand Binding Site [chemical binding]; other site 111781006749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781006750 TPR motif; other site 111781006751 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006752 binding surface 111781006753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781006754 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 111781006755 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 111781006756 Uncharacterized conserved protein [Function unknown]; Region: COG1432 111781006757 LabA_like proteins; Region: LabA; cd10911 111781006758 putative metal binding site [ion binding]; other site 111781006759 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 111781006760 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 111781006761 active site 111781006762 HIGH motif; other site 111781006763 KMSKS motif; other site 111781006764 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 111781006765 anticodon binding site; other site 111781006766 tRNA binding surface [nucleotide binding]; other site 111781006767 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 111781006768 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 111781006769 putative valine binding site [chemical binding]; other site 111781006770 dimer interface [polypeptide binding]; other site 111781006771 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 111781006772 hydrolase, alpha/beta fold family protein; Region: PLN02824 111781006773 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 111781006774 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 111781006775 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 111781006776 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 111781006777 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 111781006778 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 111781006779 active site 111781006780 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 111781006781 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 111781006782 Probable Catalytic site; other site 111781006783 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 111781006784 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 111781006785 substrate binding pocket [chemical binding]; other site 111781006786 chain length determination region; other site 111781006787 substrate-Mg2+ binding site; other site 111781006788 catalytic residues [active] 111781006789 aspartate-rich region 1; other site 111781006790 active site lid residues [active] 111781006791 aspartate-rich region 2; other site 111781006792 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 111781006793 Predicted transcriptional regulators [Transcription]; Region: COG1725 111781006794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 111781006795 DNA-binding site [nucleotide binding]; DNA binding site 111781006796 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 111781006797 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 111781006798 putative di-iron ligands [ion binding]; other site 111781006799 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 111781006800 Circadian oscillating protein COP23; Region: COP23; pfam14218 111781006801 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 111781006802 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 111781006803 active site 111781006804 ADP/pyrophosphate binding site [chemical binding]; other site 111781006805 dimerization interface [polypeptide binding]; other site 111781006806 allosteric effector site; other site 111781006807 fructose-1,6-bisphosphate binding site; other site 111781006808 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 111781006809 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 111781006810 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 111781006811 active site 111781006812 substrate binding site [chemical binding]; other site 111781006813 metal binding site [ion binding]; metal-binding site 111781006814 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 111781006815 Response regulator receiver domain; Region: Response_reg; pfam00072 111781006816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781006817 active site 111781006818 phosphorylation site [posttranslational modification] 111781006819 intermolecular recognition site; other site 111781006820 dimerization interface [polypeptide binding]; other site 111781006821 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 111781006822 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 111781006823 active site 111781006824 catalytic triad [active] 111781006825 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 111781006826 alanine racemase; Reviewed; Region: alr; PRK00053 111781006827 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 111781006828 active site 111781006829 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 111781006830 dimer interface [polypeptide binding]; other site 111781006831 substrate binding site [chemical binding]; other site 111781006832 catalytic residues [active] 111781006833 dihydroorotase; Provisional; Region: PRK07369 111781006834 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 111781006835 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 111781006836 active site 111781006837 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 111781006838 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 111781006839 homotetramer interface [polypeptide binding]; other site 111781006840 ligand binding site [chemical binding]; other site 111781006841 catalytic site [active] 111781006842 NAD binding site [chemical binding]; other site 111781006843 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 111781006844 GSH binding site [chemical binding]; other site 111781006845 catalytic residues [active] 111781006846 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 111781006847 nucleoside/Zn binding site; other site 111781006848 dimer interface [polypeptide binding]; other site 111781006849 catalytic motif [active] 111781006850 Cupin domain; Region: Cupin_2; cl17218 111781006851 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 111781006852 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 111781006853 S17 interaction site [polypeptide binding]; other site 111781006854 S8 interaction site; other site 111781006855 16S rRNA interaction site [nucleotide binding]; other site 111781006856 streptomycin interaction site [chemical binding]; other site 111781006857 23S rRNA interaction site [nucleotide binding]; other site 111781006858 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 111781006859 30S ribosomal protein S7; Validated; Region: PRK05302 111781006860 elongation factor G; Reviewed; Region: PRK00007 111781006861 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 111781006862 G1 box; other site 111781006863 putative GEF interaction site [polypeptide binding]; other site 111781006864 GTP/Mg2+ binding site [chemical binding]; other site 111781006865 Switch I region; other site 111781006866 G2 box; other site 111781006867 G3 box; other site 111781006868 Switch II region; other site 111781006869 G4 box; other site 111781006870 G5 box; other site 111781006871 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 111781006872 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 111781006873 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 111781006874 elongation factor Tu; Region: tufA; CHL00071 111781006875 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 111781006876 G1 box; other site 111781006877 GEF interaction site [polypeptide binding]; other site 111781006878 GTP/Mg2+ binding site [chemical binding]; other site 111781006879 Switch I region; other site 111781006880 G2 box; other site 111781006881 G3 box; other site 111781006882 Switch II region; other site 111781006883 G4 box; other site 111781006884 G5 box; other site 111781006885 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 111781006886 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 111781006887 Antibiotic Binding Site [chemical binding]; other site 111781006888 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 111781006889 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 111781006890 Dynamin family; Region: Dynamin_N; pfam00350 111781006891 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 111781006892 G1 box; other site 111781006893 GTP/Mg2+ binding site [chemical binding]; other site 111781006894 Switch I region; other site 111781006895 G2 box; other site 111781006896 Switch II region; other site 111781006897 G3 box; other site 111781006898 G4 box; other site 111781006899 G5 box; other site 111781006900 Domain of unknown function (DUF697); Region: DUF697; pfam05128 111781006901 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 111781006902 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 111781006903 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 111781006904 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 111781006905 catalytic site [active] 111781006906 putative active site [active] 111781006907 putative substrate binding site [chemical binding]; other site 111781006908 CpeS-like protein; Region: CpeS; pfam09367 111781006909 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 111781006910 histidinol dehydrogenase; Region: hisD; TIGR00069 111781006911 NAD binding site [chemical binding]; other site 111781006912 dimerization interface [polypeptide binding]; other site 111781006913 product binding site; other site 111781006914 substrate binding site [chemical binding]; other site 111781006915 zinc binding site [ion binding]; other site 111781006916 catalytic residues [active] 111781006917 ribosomal protein S20; Region: rps20; CHL00102 111781006918 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 111781006919 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 111781006920 active site 111781006921 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 111781006922 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 111781006923 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 111781006924 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 111781006925 RPB1 interaction site [polypeptide binding]; other site 111781006926 RPB10 interaction site [polypeptide binding]; other site 111781006927 RPB11 interaction site [polypeptide binding]; other site 111781006928 RPB3 interaction site [polypeptide binding]; other site 111781006929 RPB12 interaction site [polypeptide binding]; other site 111781006930 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 111781006931 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 111781006932 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 111781006933 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 111781006934 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 111781006935 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 111781006936 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 111781006937 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 111781006938 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 111781006939 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 111781006940 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 111781006941 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 111781006942 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 111781006943 DNA binding site [nucleotide binding] 111781006944 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781006945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781006946 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 111781006947 Aspartase; Region: Aspartase; cd01357 111781006948 active sites [active] 111781006949 tetramer interface [polypeptide binding]; other site 111781006950 GUN4-like; Region: GUN4; pfam05419 111781006951 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 111781006952 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 111781006953 active site 111781006954 nucleotide binding site [chemical binding]; other site 111781006955 HIGH motif; other site 111781006956 KMSKS motif; other site 111781006957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 111781006958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781006959 active site 111781006960 phosphorylation site [posttranslational modification] 111781006961 intermolecular recognition site; other site 111781006962 dimerization interface [polypeptide binding]; other site 111781006963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781006964 dimerization interface [polypeptide binding]; other site 111781006965 DNA binding residues [nucleotide binding] 111781006966 Predicted membrane protein [Function unknown]; Region: COG2324 111781006967 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 111781006968 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 111781006969 active site 111781006970 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 111781006971 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 111781006972 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 111781006973 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 111781006974 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781006975 TIGR04168 family protein; Region: TIGR04168 111781006976 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 111781006977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781006978 dimer interface [polypeptide binding]; other site 111781006979 putative metal binding site [ion binding]; other site 111781006980 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 111781006981 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 111781006982 metal binding site [ion binding]; metal-binding site 111781006983 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 111781006984 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 111781006985 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 111781006986 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 111781006987 ABC-ATPase subunit interface; other site 111781006988 dimer interface [polypeptide binding]; other site 111781006989 putative PBP binding regions; other site 111781006990 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781006991 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781006992 catalytic loop [active] 111781006993 iron binding site [ion binding]; other site 111781006994 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781006995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 111781006996 active site 111781006997 intermolecular recognition site; other site 111781006998 dimerization interface [polypeptide binding]; other site 111781006999 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781007000 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781007001 catalytic loop [active] 111781007002 iron binding site [ion binding]; other site 111781007003 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 111781007004 V4R domain; Region: V4R; cl15268 111781007005 Phycobilisome protein; Region: Phycobilisome; cl08227 111781007006 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 111781007007 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 111781007008 heme binding site [chemical binding]; other site 111781007009 ferroxidase pore; other site 111781007010 ferroxidase diiron center [ion binding]; other site 111781007011 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 111781007012 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 111781007013 heme binding site [chemical binding]; other site 111781007014 ferroxidase pore; other site 111781007015 ferroxidase diiron center [ion binding]; other site 111781007016 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 111781007017 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 111781007018 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 111781007019 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 111781007020 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 111781007021 catalytic core [active] 111781007022 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 111781007023 S-layer homology domain; Region: SLH; pfam00395 111781007024 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781007025 S-layer homology domain; Region: SLH; pfam00395 111781007026 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781007027 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 111781007028 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 111781007029 putative NAD(P) binding site [chemical binding]; other site 111781007030 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781007031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781007032 catalytic loop [active] 111781007033 iron binding site [ion binding]; other site 111781007034 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 111781007035 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 111781007036 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 111781007037 quinone interaction residues [chemical binding]; other site 111781007038 active site 111781007039 catalytic residues [active] 111781007040 FMN binding site [chemical binding]; other site 111781007041 substrate binding site [chemical binding]; other site 111781007042 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 111781007043 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 111781007044 Aluminium resistance protein; Region: Alum_res; pfam06838 111781007045 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 111781007046 Fatty acid desaturase; Region: FA_desaturase; pfam00487 111781007047 Di-iron ligands [ion binding]; other site 111781007048 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781007049 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781007050 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781007051 ligand binding site [chemical binding]; other site 111781007052 flexible hinge region; other site 111781007053 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 111781007054 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 111781007055 intersubunit interface [polypeptide binding]; other site 111781007056 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 111781007057 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 111781007058 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 111781007059 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 111781007060 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 111781007061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 111781007062 ABC-ATPase subunit interface; other site 111781007063 dimer interface [polypeptide binding]; other site 111781007064 putative PBP binding regions; other site 111781007065 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 111781007066 metal binding site 2 [ion binding]; metal-binding site 111781007067 putative DNA binding helix; other site 111781007068 metal binding site 1 [ion binding]; metal-binding site 111781007069 dimer interface [polypeptide binding]; other site 111781007070 structural Zn2+ binding site [ion binding]; other site 111781007071 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 111781007072 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 111781007073 trimer interface [polypeptide binding]; other site 111781007074 putative metal binding site [ion binding]; other site 111781007075 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781007076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007077 binding surface 111781007078 TPR motif; other site 111781007079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007080 binding surface 111781007081 TPR motif; other site 111781007082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007083 binding surface 111781007084 TPR motif; other site 111781007085 CHAT domain; Region: CHAT; pfam12770 111781007086 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781007087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781007088 dimer interface [polypeptide binding]; other site 111781007089 phosphorylation site [posttranslational modification] 111781007090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781007091 ATP binding site [chemical binding]; other site 111781007092 G-X-G motif; other site 111781007093 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 111781007094 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 111781007095 putative active site [active] 111781007096 catalytic triad [active] 111781007097 putative dimer interface [polypeptide binding]; other site 111781007098 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 111781007099 active site 111781007100 oligomerization interface [polypeptide binding]; other site 111781007101 metal binding site [ion binding]; metal-binding site 111781007102 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 111781007103 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781007104 anti sigma factor interaction site; other site 111781007105 regulatory phosphorylation site [posttranslational modification]; other site 111781007106 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 111781007107 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 111781007108 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 111781007109 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 111781007110 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 111781007111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007112 binding surface 111781007113 TPR motif; other site 111781007114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007115 binding surface 111781007116 TPR motif; other site 111781007117 TPR repeat; Region: TPR_11; pfam13414 111781007118 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 111781007119 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 111781007120 CAP-like domain; other site 111781007121 active site 111781007122 primary dimer interface [polypeptide binding]; other site 111781007123 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781007124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781007125 Response regulator receiver domain; Region: Response_reg; pfam00072 111781007126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781007127 active site 111781007128 phosphorylation site [posttranslational modification] 111781007129 intermolecular recognition site; other site 111781007130 dimerization interface [polypeptide binding]; other site 111781007131 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 111781007132 active site lid residues [active] 111781007133 substrate binding pocket [chemical binding]; other site 111781007134 catalytic residues [active] 111781007135 substrate-Mg2+ binding site; other site 111781007136 aspartate-rich region 1; other site 111781007137 aspartate-rich region 2; other site 111781007138 phytoene desaturase; Region: phytoene_desat; TIGR02731 111781007139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781007140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781007141 Ligand Binding Site [chemical binding]; other site 111781007142 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 111781007143 Ligand Binding Site [chemical binding]; other site 111781007144 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 111781007145 Uncharacterized conserved protein [Function unknown]; Region: COG1801 111781007146 Phycobilisome protein; Region: Phycobilisome; cl08227 111781007147 allophycocyanin beta subunit; Region: apcB; CHL00088 111781007148 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 111781007149 O-Antigen ligase; Region: Wzy_C; pfam04932 111781007150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007151 TPR motif; other site 111781007152 binding surface 111781007153 adenylosuccinate lyase; Provisional; Region: PRK07380 111781007154 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 111781007155 tetramer interface [polypeptide binding]; other site 111781007156 active site 111781007157 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 111781007158 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781007159 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 111781007160 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 111781007161 active site 111781007162 SAM binding site [chemical binding]; other site 111781007163 homodimer interface [polypeptide binding]; other site 111781007164 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 111781007165 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 111781007166 active site 111781007167 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 111781007168 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 111781007169 oligomer interface [polypeptide binding]; other site 111781007170 active site residues [active] 111781007171 Clp protease; Region: CLP_protease; pfam00574 111781007172 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 111781007173 oligomer interface [polypeptide binding]; other site 111781007174 active site residues [active] 111781007175 Circadian oscillating protein COP23; Region: COP23; pfam14218 111781007176 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 111781007177 active site pocket [active] 111781007178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781007179 Homeodomain-like domain; Region: HTH_32; pfam13565 111781007180 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781007181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781007182 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 111781007183 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 111781007184 TIGR03790 family protein; Region: TIGR03790 111781007185 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 111781007186 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 111781007187 amidophosphoribosyltransferase; Provisional; Region: PRK07349 111781007188 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 111781007189 active site 111781007190 tetramer interface [polypeptide binding]; other site 111781007191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781007192 active site 111781007193 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 111781007194 PHP domain; Region: PHP; pfam02811 111781007195 active site 111781007196 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 111781007197 D-xylulose kinase; Region: XylB; TIGR01312 111781007198 nucleotide binding site [chemical binding]; other site 111781007199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781007200 calcium/proton exchanger (cax); Region: cax; TIGR00378 111781007201 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 111781007202 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 111781007203 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 111781007204 hypothetical protein; Reviewed; Region: PRK09588 111781007205 ribosomal protein S14; Region: rps14; CHL00074 111781007206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781007207 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781007208 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781007209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781007210 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781007211 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 111781007212 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 111781007213 Uncharacterized conserved protein [Function unknown]; Region: COG3339 111781007214 photosystem II 47 kDa protein; Region: psbB; CHL00062 111781007215 GUN4-like; Region: GUN4; pfam05419 111781007216 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 111781007217 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 111781007218 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 111781007219 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 111781007220 glutamine binding [chemical binding]; other site 111781007221 catalytic triad [active] 111781007222 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 111781007223 metal-binding heat shock protein; Provisional; Region: PRK00016 111781007224 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 111781007225 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781007226 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 111781007227 putative NAD(P) binding site [chemical binding]; other site 111781007228 active site 111781007229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781007230 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 111781007231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 111781007232 conserved hypothetical protein; Region: TIGR03492 111781007233 Domain of unknown function (DUF309); Region: DUF309; pfam03745 111781007234 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 111781007235 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 111781007236 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 111781007237 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 111781007238 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 111781007239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781007240 Homeodomain-like domain; Region: HTH_32; pfam13565 111781007241 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781007242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781007243 HAS barrel domain; Region: HAS-barrel; pfam09378 111781007244 HerA helicase [Replication, recombination, and repair]; Region: COG0433 111781007245 Domain of unknown function DUF87; Region: DUF87; pfam01935 111781007246 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 111781007247 metal binding site [ion binding]; metal-binding site 111781007248 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 111781007249 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 111781007250 biotin synthase; Region: bioB; TIGR00433 111781007251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781007252 FeS/SAM binding site; other site 111781007253 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 111781007254 BioY family; Region: BioY; pfam02632 111781007255 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 111781007256 lipoprotein signal peptidase; Provisional; Region: PRK14787 111781007257 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 111781007258 EamA-like transporter family; Region: EamA; pfam00892 111781007259 EamA-like transporter family; Region: EamA; pfam00892 111781007260 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781007261 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781007262 structural tetrad; other site 111781007263 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 111781007264 recombination protein RecR; Reviewed; Region: recR; PRK00076 111781007265 RecR protein; Region: RecR; pfam02132 111781007266 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 111781007267 putative active site [active] 111781007268 putative metal-binding site [ion binding]; other site 111781007269 tetramer interface [polypeptide binding]; other site 111781007270 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 111781007271 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 111781007272 active site 111781007273 metal binding site [ion binding]; metal-binding site 111781007274 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 111781007275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781007276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781007277 Coenzyme A binding pocket [chemical binding]; other site 111781007278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781007279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781007280 dimer interface [polypeptide binding]; other site 111781007281 phosphorylation site [posttranslational modification] 111781007282 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 111781007283 Cysteine-rich domain; Region: CCG; pfam02754 111781007284 Cysteine-rich domain; Region: CCG; pfam02754 111781007285 phosphoribulokinase; Provisional; Region: PRK15453 111781007286 active site 111781007287 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 111781007288 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 111781007289 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 111781007290 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 111781007291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781007292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781007293 active site 111781007294 phosphorylation site [posttranslational modification] 111781007295 intermolecular recognition site; other site 111781007296 dimerization interface [polypeptide binding]; other site 111781007297 Response regulator receiver domain; Region: Response_reg; pfam00072 111781007298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781007299 active site 111781007300 phosphorylation site [posttranslational modification] 111781007301 intermolecular recognition site; other site 111781007302 dimerization interface [polypeptide binding]; other site 111781007303 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 111781007304 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 111781007305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781007306 dimerization interface [polypeptide binding]; other site 111781007307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 111781007308 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 111781007309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 111781007310 dimer interface [polypeptide binding]; other site 111781007311 putative CheW interface [polypeptide binding]; other site 111781007312 Permease; Region: Permease; cl00510 111781007313 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 111781007314 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 111781007315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 111781007316 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 111781007317 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 111781007318 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 111781007319 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 111781007320 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 111781007321 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 111781007322 PBP superfamily domain; Region: PBP_like_2; cl17296 111781007323 PBP superfamily domain; Region: PBP_like_2; cl17296 111781007324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781007325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781007326 dimer interface [polypeptide binding]; other site 111781007327 phosphorylation site [posttranslational modification] 111781007328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781007329 ATP binding site [chemical binding]; other site 111781007330 Mg2+ binding site [ion binding]; other site 111781007331 G-X-G motif; other site 111781007332 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781007333 putative active site [active] 111781007334 NB-ARC domain; Region: NB-ARC; pfam00931 111781007335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781007336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007337 binding surface 111781007338 TPR motif; other site 111781007339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781007340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007341 binding surface 111781007342 TPR motif; other site 111781007343 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781007344 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 111781007345 Sporulation and spore germination; Region: Germane; pfam10646 111781007346 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 111781007347 catalytic residue [active] 111781007348 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 111781007349 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 111781007350 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 111781007351 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 111781007352 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 111781007353 active site 111781007354 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 111781007355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781007356 dimer interface [polypeptide binding]; other site 111781007357 phosphorylation site [posttranslational modification] 111781007358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781007359 ATP binding site [chemical binding]; other site 111781007360 Mg2+ binding site [ion binding]; other site 111781007361 G-X-G motif; other site 111781007362 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 111781007363 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 111781007364 TM-ABC transporter signature motif; other site 111781007365 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 111781007366 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 111781007367 TM-ABC transporter signature motif; other site 111781007368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781007369 ATP binding site [chemical binding]; other site 111781007370 Mg2+ binding site [ion binding]; other site 111781007371 G-X-G motif; other site 111781007372 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 111781007373 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 111781007374 active site 111781007375 ATP binding site [chemical binding]; other site 111781007376 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 111781007377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781007378 dimerization interface [polypeptide binding]; other site 111781007379 PAS domain S-box; Region: sensory_box; TIGR00229 111781007380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781007381 putative active site [active] 111781007382 heme pocket [chemical binding]; other site 111781007383 cyclase homology domain; Region: CHD; cd07302 111781007384 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781007385 nucleotidyl binding site; other site 111781007386 metal binding site [ion binding]; metal-binding site 111781007387 dimer interface [polypeptide binding]; other site 111781007388 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 111781007389 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 111781007390 Hexamer interface [polypeptide binding]; other site 111781007391 Hexagonal pore residue; other site 111781007392 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 111781007393 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 111781007394 Hexamer interface [polypeptide binding]; other site 111781007395 Hexagonal pore residue; other site 111781007396 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 111781007397 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 111781007398 putative catalytic cysteine [active] 111781007399 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 111781007400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781007401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781007402 dimer interface [polypeptide binding]; other site 111781007403 phosphorylation site [posttranslational modification] 111781007404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781007405 ATP binding site [chemical binding]; other site 111781007406 Mg2+ binding site [ion binding]; other site 111781007407 G-X-G motif; other site 111781007408 Response regulator receiver domain; Region: Response_reg; pfam00072 111781007409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781007410 active site 111781007411 phosphorylation site [posttranslational modification] 111781007412 intermolecular recognition site; other site 111781007413 dimerization interface [polypeptide binding]; other site 111781007414 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 111781007415 homodimer interface [polypeptide binding]; other site 111781007416 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 111781007417 active site pocket [active] 111781007418 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 111781007419 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 111781007420 metal ion-dependent adhesion site (MIDAS); other site 111781007421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781007422 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781007423 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781007424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781007425 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781007426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781007427 Predicted permeases [General function prediction only]; Region: COG0679 111781007428 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 111781007429 DHH family; Region: DHH; pfam01368 111781007430 DHHA1 domain; Region: DHHA1; pfam02272 111781007431 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 111781007432 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 111781007433 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 111781007434 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 111781007435 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 111781007436 S-layer homology domain; Region: SLH; pfam00395 111781007437 S-layer homology domain; Region: SLH; pfam00395 111781007438 S-layer homology domain; Region: SLH; pfam00395 111781007439 S-layer homology domain; Region: SLH; pfam00395 111781007440 S-layer homology domain; Region: SLH; pfam00395 111781007441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 111781007442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781007443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 111781007444 dimerization interface [polypeptide binding]; other site 111781007445 Phycobilisome protein; Region: Phycobilisome; cl08227 111781007446 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 111781007447 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 111781007448 GrpE; Region: GrpE; pfam01025 111781007449 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 111781007450 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 111781007451 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 111781007452 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 111781007453 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 111781007454 dimer interface [polypeptide binding]; other site 111781007455 tetramer interface [polypeptide binding]; other site 111781007456 PYR/PP interface [polypeptide binding]; other site 111781007457 TPP binding site [chemical binding]; other site 111781007458 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 111781007459 TPP-binding site; other site 111781007460 glycogen synthase; Provisional; Region: glgA; PRK00654 111781007461 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 111781007462 ADP-binding pocket [chemical binding]; other site 111781007463 homodimer interface [polypeptide binding]; other site 111781007464 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781007465 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 111781007466 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 111781007467 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 111781007468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781007469 Walker A motif; other site 111781007470 ATP binding site [chemical binding]; other site 111781007471 Walker B motif; other site 111781007472 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 111781007473 Clp protease; Region: CLP_protease; pfam00574 111781007474 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 111781007475 oligomer interface [polypeptide binding]; other site 111781007476 active site residues [active] 111781007477 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 111781007478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781007479 Walker A/P-loop; other site 111781007480 ATP binding site [chemical binding]; other site 111781007481 Q-loop/lid; other site 111781007482 ABC transporter signature motif; other site 111781007483 Walker B; other site 111781007484 D-loop; other site 111781007485 H-loop/switch region; other site 111781007486 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 111781007487 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 111781007488 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 111781007489 Part of AAA domain; Region: AAA_19; pfam13245 111781007490 Family description; Region: UvrD_C_2; pfam13538 111781007491 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 111781007492 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 111781007493 ribonuclease PH; Reviewed; Region: rph; PRK00173 111781007494 Ribonuclease PH; Region: RNase_PH_bact; cd11362 111781007495 hexamer interface [polypeptide binding]; other site 111781007496 active site 111781007497 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 111781007498 Catalytic site [active] 111781007499 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 111781007500 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 111781007501 substrate binding site [chemical binding]; other site 111781007502 glutamase interaction surface [polypeptide binding]; other site 111781007503 Protein of unknown function (DUF561); Region: DUF561; pfam04481 111781007504 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 111781007505 dimer interface [polypeptide binding]; other site 111781007506 [2Fe-2S] cluster binding site [ion binding]; other site 111781007507 response regulator FixJ; Provisional; Region: fixJ; PRK09390 111781007508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781007509 active site 111781007510 phosphorylation site [posttranslational modification] 111781007511 intermolecular recognition site; other site 111781007512 dimerization interface [polypeptide binding]; other site 111781007513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781007514 DNA binding residues [nucleotide binding] 111781007515 dimerization interface [polypeptide binding]; other site 111781007516 competence damage-inducible protein A; Provisional; Region: PRK00549 111781007517 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 111781007518 putative MPT binding site; other site 111781007519 Competence-damaged protein; Region: CinA; pfam02464 111781007520 Dehydroquinase class II; Region: DHquinase_II; pfam01220 111781007521 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 111781007522 trimer interface [polypeptide binding]; other site 111781007523 active site 111781007524 dimer interface [polypeptide binding]; other site 111781007525 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 111781007526 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 111781007527 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 111781007528 putative active site [active] 111781007529 oxyanion strand; other site 111781007530 catalytic triad [active] 111781007531 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 111781007532 tetramerization interface [polypeptide binding]; other site 111781007533 active site 111781007534 Uncharacterized conserved protein [Function unknown]; Region: COG1434 111781007535 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 111781007536 putative active site [active] 111781007537 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 111781007538 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 111781007539 active site 111781007540 intersubunit interactions; other site 111781007541 catalytic residue [active] 111781007542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781007543 BT1 family; Region: BT1; pfam03092 111781007544 putative substrate translocation pore; other site 111781007545 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 111781007546 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 111781007547 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 111781007548 Catalytic site [active] 111781007549 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 111781007550 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 111781007551 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 111781007552 NAD(P) binding site [chemical binding]; other site 111781007553 LDH/MDH dimer interface [polypeptide binding]; other site 111781007554 substrate binding site [chemical binding]; other site 111781007555 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 111781007556 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 111781007557 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 111781007558 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 111781007559 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 111781007560 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 111781007561 metal binding site [ion binding]; metal-binding site 111781007562 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 111781007563 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 111781007564 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781007565 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 111781007566 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 111781007567 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 111781007568 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 111781007569 putative substrate binding site [chemical binding]; other site 111781007570 putative ATP binding site [chemical binding]; other site 111781007571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781007572 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781007573 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781007574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781007575 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 111781007576 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 111781007577 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 111781007578 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 111781007579 Mg++ binding site [ion binding]; other site 111781007580 putative catalytic motif [active] 111781007581 putative substrate binding site [chemical binding]; other site 111781007582 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 111781007583 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 111781007584 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 111781007585 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 111781007586 Clp amino terminal domain; Region: Clp_N; pfam02861 111781007587 Clp amino terminal domain; Region: Clp_N; pfam02861 111781007588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781007589 Walker A motif; other site 111781007590 ATP binding site [chemical binding]; other site 111781007591 Walker B motif; other site 111781007592 arginine finger; other site 111781007593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781007594 Walker A motif; other site 111781007595 ATP binding site [chemical binding]; other site 111781007596 Walker B motif; other site 111781007597 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 111781007598 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 111781007599 active sites [active] 111781007600 tetramer interface [polypeptide binding]; other site 111781007601 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 111781007602 RibD C-terminal domain; Region: RibD_C; cl17279 111781007603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781007604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781007605 active site 111781007606 ATP binding site [chemical binding]; other site 111781007607 substrate binding site [chemical binding]; other site 111781007608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 111781007609 substrate binding site [chemical binding]; other site 111781007610 activation loop (A-loop); other site 111781007611 activation loop (A-loop); other site 111781007612 AAA ATPase domain; Region: AAA_16; pfam13191 111781007613 Predicted ATPase [General function prediction only]; Region: COG3899 111781007614 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781007615 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781007616 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 111781007617 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 111781007618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781007619 ATP binding site [chemical binding]; other site 111781007620 Mg2+ binding site [ion binding]; other site 111781007621 G-X-G motif; other site 111781007622 Response regulator receiver domain; Region: Response_reg; pfam00072 111781007623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781007624 active site 111781007625 phosphorylation site [posttranslational modification] 111781007626 intermolecular recognition site; other site 111781007627 dimerization interface [polypeptide binding]; other site 111781007628 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781007629 cyclase homology domain; Region: CHD; cd07302 111781007630 nucleotidyl binding site; other site 111781007631 metal binding site [ion binding]; metal-binding site 111781007632 dimer interface [polypeptide binding]; other site 111781007633 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 111781007634 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 111781007635 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 111781007636 Cysteine-rich domain; Region: CCG; pfam02754 111781007637 Cysteine-rich domain; Region: CCG; pfam02754 111781007638 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 111781007639 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 111781007640 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 111781007641 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 111781007642 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 111781007643 HIGH motif; other site 111781007644 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 111781007645 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 111781007646 active site 111781007647 KMSKS motif; other site 111781007648 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 111781007649 tRNA binding surface [nucleotide binding]; other site 111781007650 anticodon binding site; other site 111781007651 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 111781007652 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 111781007653 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 111781007654 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781007655 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781007656 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781007657 homoserine dehydrogenase; Provisional; Region: PRK06349 111781007658 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 111781007659 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 111781007660 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 111781007661 Predicted integral membrane protein [Function unknown]; Region: COG0762 111781007662 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 111781007663 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 111781007664 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 111781007665 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 111781007666 Predicted integral membrane protein [Function unknown]; Region: COG0762 111781007667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781007668 active site 111781007669 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 111781007670 MoaE homodimer interface [polypeptide binding]; other site 111781007671 MoaD interaction [polypeptide binding]; other site 111781007672 active site residues [active] 111781007673 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 111781007674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781007675 FeS/SAM binding site; other site 111781007676 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 111781007677 GMP synthase; Reviewed; Region: guaA; PRK00074 111781007678 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 111781007679 AMP/PPi binding site [chemical binding]; other site 111781007680 candidate oxyanion hole; other site 111781007681 catalytic triad [active] 111781007682 potential glutamine specificity residues [chemical binding]; other site 111781007683 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 111781007684 ATP Binding subdomain [chemical binding]; other site 111781007685 Ligand Binding sites [chemical binding]; other site 111781007686 Dimerization subdomain; other site 111781007687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 111781007688 Cupin-like domain; Region: Cupin_8; pfam13621 111781007689 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 111781007690 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 111781007691 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781007692 putative active site [active] 111781007693 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 111781007694 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 111781007695 active site 111781007696 PHP Thumb interface [polypeptide binding]; other site 111781007697 metal binding site [ion binding]; metal-binding site 111781007698 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 111781007699 protein-splicing catalytic site; other site 111781007700 thioester formation/cholesterol transfer; other site 111781007701 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 111781007702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 111781007703 active site 111781007704 Peptidase M15; Region: Peptidase_M15_3; cl01194 111781007705 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 111781007706 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 111781007707 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781007708 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781007709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781007710 GNT-I family; Region: GNT-I; pfam03071 111781007711 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781007712 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 111781007713 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 111781007714 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 111781007715 Helix-turn-helix domain; Region: HTH_25; pfam13413 111781007716 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 111781007717 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 111781007718 DNA binding site [nucleotide binding] 111781007719 catalytic residue [active] 111781007720 H2TH interface [polypeptide binding]; other site 111781007721 putative catalytic residues [active] 111781007722 turnover-facilitating residue; other site 111781007723 intercalation triad [nucleotide binding]; other site 111781007724 8OG recognition residue [nucleotide binding]; other site 111781007725 putative reading head residues; other site 111781007726 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 111781007727 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 111781007728 CAAX protease self-immunity; Region: Abi; pfam02517 111781007729 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 111781007730 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 111781007731 active site flap/lid [active] 111781007732 nucleophilic elbow; other site 111781007733 catalytic triad [active] 111781007734 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 111781007735 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 111781007736 Substrate binding site; other site 111781007737 Mg++ binding site; other site 111781007738 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 111781007739 active site 111781007740 substrate binding site [chemical binding]; other site 111781007741 CoA binding site [chemical binding]; other site 111781007742 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 111781007743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781007744 FeS/SAM binding site; other site 111781007745 ABC-2 type transporter; Region: ABC2_membrane; cl17235 111781007746 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 111781007747 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 111781007748 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 111781007749 substrate binding site [chemical binding]; other site 111781007750 hexamer interface [polypeptide binding]; other site 111781007751 metal binding site [ion binding]; metal-binding site 111781007752 Ion channel; Region: Ion_trans_2; pfam07885 111781007753 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 111781007754 TrkA-N domain; Region: TrkA_N; pfam02254 111781007755 TrkA-C domain; Region: TrkA_C; pfam02080 111781007756 acetylornithine aminotransferase; Provisional; Region: PRK02627 111781007757 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 111781007758 inhibitor-cofactor binding pocket; inhibition site 111781007759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781007760 catalytic residue [active] 111781007761 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 111781007762 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 111781007763 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 111781007764 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 111781007765 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 111781007766 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 111781007767 RimK-like ATP-grasp domain; Region: RimK; pfam08443 111781007768 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 111781007769 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781007770 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781007771 active site 111781007772 ATP binding site [chemical binding]; other site 111781007773 substrate binding site [chemical binding]; other site 111781007774 activation loop (A-loop); other site 111781007775 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781007776 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781007777 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781007778 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781007779 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781007780 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781007781 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781007782 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781007783 active site 111781007784 ATP binding site [chemical binding]; other site 111781007785 substrate binding site [chemical binding]; other site 111781007786 activation loop (A-loop); other site 111781007787 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 111781007788 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 111781007789 dimer interface [polypeptide binding]; other site 111781007790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781007791 catalytic residue [active] 111781007792 MOSC domain; Region: MOSC; pfam03473 111781007793 Repair protein; Region: Repair_PSII; pfam04536 111781007794 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 111781007795 homodimer interface [polypeptide binding]; other site 111781007796 substrate-cofactor binding pocket; other site 111781007797 Aminotransferase class IV; Region: Aminotran_4; pfam01063 111781007798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781007799 catalytic residue [active] 111781007800 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781007801 ligand binding site [chemical binding]; other site 111781007802 flexible hinge region; other site 111781007803 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 111781007804 CHASE4 domain; Region: CHASE4; cl01308 111781007805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781007806 dimerization interface [polypeptide binding]; other site 111781007807 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781007808 cyclase homology domain; Region: CHD; cd07302 111781007809 nucleotidyl binding site; other site 111781007810 metal binding site [ion binding]; metal-binding site 111781007811 dimer interface [polypeptide binding]; other site 111781007812 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 111781007813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781007814 Walker A/P-loop; other site 111781007815 ATP binding site [chemical binding]; other site 111781007816 Q-loop/lid; other site 111781007817 ABC transporter signature motif; other site 111781007818 Walker B; other site 111781007819 D-loop; other site 111781007820 H-loop/switch region; other site 111781007821 TOBE domain; Region: TOBE_2; pfam08402 111781007822 Oligomerisation domain; Region: Oligomerisation; pfam02410 111781007823 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781007824 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007825 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007826 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007827 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007828 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007829 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 111781007830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781007831 active site 111781007832 metal binding site [ion binding]; metal-binding site 111781007833 Rhomboid family; Region: Rhomboid; pfam01694 111781007834 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 111781007835 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 111781007836 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 111781007837 Ligand binding site; other site 111781007838 Putative Catalytic site; other site 111781007839 DXD motif; other site 111781007840 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 111781007841 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 111781007842 putative catalytic residues [active] 111781007843 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 111781007844 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 111781007845 active site 111781007846 substrate binding site [chemical binding]; other site 111781007847 metal binding site [ion binding]; metal-binding site 111781007848 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781007849 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781007850 CHAT domain; Region: CHAT; pfam12770 111781007851 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 111781007852 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 111781007853 Protein of unknown function DUF58; Region: DUF58; pfam01882 111781007854 MoxR-like ATPases [General function prediction only]; Region: COG0714 111781007855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781007856 Walker A motif; other site 111781007857 ATP binding site [chemical binding]; other site 111781007858 Walker B motif; other site 111781007859 arginine finger; other site 111781007860 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 111781007861 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 111781007862 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 111781007863 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 111781007864 active site residue [active] 111781007865 cobyric acid synthase; Provisional; Region: PRK00784 111781007866 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 111781007867 conserved cys residue [active] 111781007868 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 111781007869 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 111781007870 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 111781007871 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 111781007872 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 111781007873 S-adenosylmethionine synthetase; Validated; Region: PRK05250 111781007874 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 111781007875 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 111781007876 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 111781007877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781007878 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781007879 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781007880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781007881 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 111781007882 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 111781007883 NAD binding site [chemical binding]; other site 111781007884 homodimer interface [polypeptide binding]; other site 111781007885 active site 111781007886 substrate binding site [chemical binding]; other site 111781007887 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 111781007888 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 111781007889 YceG-like family; Region: YceG; pfam02618 111781007890 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 111781007891 dimerization interface [polypeptide binding]; other site 111781007892 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 111781007893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 111781007894 Walker A motif; other site 111781007895 ATP binding site [chemical binding]; other site 111781007896 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 111781007897 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781007898 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007899 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007900 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781007901 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 111781007902 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 111781007903 Resolvase, N terminal domain; Region: Resolvase; smart00857 111781007904 catalytic residues [active] 111781007905 Recombinase; Region: Recombinase; pfam07508 111781007906 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 111781007907 Bifunctional nuclease; Region: DNase-RNase; pfam02577 111781007908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781007909 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781007910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781007911 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781007912 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781007913 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781007914 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 111781007915 Precorrin-8X methylmutase; Region: CbiC; pfam02570 111781007916 light-harvesting-like protein 3; Provisional; Region: PLN00014 111781007917 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 111781007918 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 111781007919 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781007920 PsbJ; Region: PsbJ; cl09469 111781007921 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 111781007922 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 111781007923 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 111781007924 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 111781007925 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 111781007926 Ycf48-like protein; Provisional; Region: PRK13684 111781007927 Rubredoxin; Region: Rubredoxin; pfam00301 111781007928 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 111781007929 iron binding site [ion binding]; other site 111781007930 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 111781007931 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 111781007932 TrkA-N domain; Region: TrkA_N; pfam02254 111781007933 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 111781007934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781007935 binding surface 111781007936 TPR motif; other site 111781007937 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 111781007938 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 111781007939 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 111781007940 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 111781007941 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 111781007942 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 111781007943 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 111781007944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781007945 S-adenosylmethionine binding site [chemical binding]; other site 111781007946 Tic22-like family; Region: Tic22; cl04468 111781007947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781007948 Coenzyme A binding pocket [chemical binding]; other site 111781007949 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 111781007950 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 111781007951 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 111781007952 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 111781007953 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 111781007954 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 111781007955 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 111781007956 photosystem I subunit VII; Region: psaC; CHL00065 111781007957 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 111781007958 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781007959 FOG: CBS domain [General function prediction only]; Region: COG0517 111781007960 FOG: CBS domain [General function prediction only]; Region: COG0517 111781007961 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 111781007962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781007963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781007964 metal binding site [ion binding]; metal-binding site 111781007965 active site 111781007966 I-site; other site 111781007967 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 111781007968 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 111781007969 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 111781007970 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 111781007971 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 111781007972 Active Sites [active] 111781007973 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 111781007974 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 111781007975 active site residue [active] 111781007976 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 111781007977 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 111781007978 active site 111781007979 NTP binding site [chemical binding]; other site 111781007980 metal binding triad [ion binding]; metal-binding site 111781007981 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 111781007982 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 111781007983 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 111781007984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781007985 dimer interface [polypeptide binding]; other site 111781007986 conserved gate region; other site 111781007987 putative PBP binding loops; other site 111781007988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 111781007989 ABC-ATPase subunit interface; other site 111781007990 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 111781007991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781007992 dimer interface [polypeptide binding]; other site 111781007993 conserved gate region; other site 111781007994 putative PBP binding loops; other site 111781007995 ABC-ATPase subunit interface; other site 111781007996 phosphate binding protein; Region: ptsS_2; TIGR02136 111781007997 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 111781007998 Glucose inhibited division protein A; Region: GIDA; pfam01134 111781007999 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 111781008000 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 111781008001 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 111781008002 putative acyl-acceptor binding pocket; other site 111781008003 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 111781008004 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 111781008005 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 111781008006 active site 111781008007 Riboflavin kinase; Region: Flavokinase; smart00904 111781008008 MoxR-like ATPases [General function prediction only]; Region: COG0714 111781008009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781008010 Walker A motif; other site 111781008011 ATP binding site [chemical binding]; other site 111781008012 Walker B motif; other site 111781008013 arginine finger; other site 111781008014 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 111781008015 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 111781008016 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 111781008017 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 111781008018 TrkA-N domain; Region: TrkA_N; pfam02254 111781008019 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 111781008020 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781008021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781008022 S-adenosylmethionine binding site [chemical binding]; other site 111781008023 phycobillisome linker protein; Region: apcE; CHL00091 111781008024 Phycobilisome protein; Region: Phycobilisome; cl08227 111781008025 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781008026 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781008027 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781008028 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781008029 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781008030 CHAT domain; Region: CHAT; cl17868 111781008031 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 111781008032 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 111781008033 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 111781008034 active site residue [active] 111781008035 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 111781008036 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781008037 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 111781008038 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 111781008039 putative phosphate acyltransferase; Provisional; Region: PRK05331 111781008040 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 111781008041 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 111781008042 dimer interface [polypeptide binding]; other site 111781008043 active site 111781008044 CoA binding pocket [chemical binding]; other site 111781008045 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 111781008046 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 111781008047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 111781008048 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 111781008049 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 111781008050 putative active site pocket [active] 111781008051 4-fold oligomerization interface [polypeptide binding]; other site 111781008052 metal binding residues [ion binding]; metal-binding site 111781008053 3-fold/trimer interface [polypeptide binding]; other site 111781008054 Uncharacterized conserved protein [Function unknown]; Region: COG3937 111781008055 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 111781008056 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 111781008057 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 111781008058 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781008059 iron-sulfur cluster [ion binding]; other site 111781008060 [2Fe-2S] cluster binding site [ion binding]; other site 111781008061 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 111781008062 ResB-like family; Region: ResB; pfam05140 111781008063 ResB-like family; Region: ResB; pfam05140 111781008064 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 111781008065 heme-binding site [chemical binding]; other site 111781008066 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 111781008067 heme-binding site [chemical binding]; other site 111781008068 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 111781008069 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 111781008070 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 111781008071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 111781008072 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 111781008073 Protein of unknown function, DUF399; Region: DUF399; pfam04187 111781008074 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781008075 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781008076 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008077 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008078 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008079 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 111781008080 putative rRNA binding site [nucleotide binding]; other site 111781008081 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781008082 putative active site [active] 111781008083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781008084 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 111781008085 active site 111781008086 metal binding site [ion binding]; metal-binding site 111781008087 Integral membrane protein DUF92; Region: DUF92; pfam01940 111781008088 GLTT repeat (6 copies); Region: GLTT; pfam01744 111781008089 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 111781008090 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 111781008091 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 111781008092 HAMP domain; Region: HAMP; pfam00672 111781008093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008094 ATP binding site [chemical binding]; other site 111781008095 Mg2+ binding site [ion binding]; other site 111781008096 G-X-G motif; other site 111781008097 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781008098 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008100 active site 111781008101 phosphorylation site [posttranslational modification] 111781008102 intermolecular recognition site; other site 111781008103 dimerization interface [polypeptide binding]; other site 111781008104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781008105 metal binding site [ion binding]; metal-binding site 111781008106 active site 111781008107 I-site; other site 111781008108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781008109 phage shock protein A; Region: phageshock_pspA; TIGR02977 111781008110 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 111781008111 active site 111781008112 multimer interface [polypeptide binding]; other site 111781008113 NurA nuclease; Region: NurA; smart00933 111781008114 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 111781008115 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 111781008116 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 111781008117 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 111781008118 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 111781008119 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 111781008120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781008121 dimer interface [polypeptide binding]; other site 111781008122 conserved gate region; other site 111781008123 ABC-ATPase subunit interface; other site 111781008124 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 111781008125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781008126 S-adenosylmethionine binding site [chemical binding]; other site 111781008127 MASE1; Region: MASE1; pfam05231 111781008128 PAS fold; Region: PAS_4; pfam08448 111781008129 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781008130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781008131 metal binding site [ion binding]; metal-binding site 111781008132 active site 111781008133 I-site; other site 111781008134 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 111781008135 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 111781008136 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 111781008137 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 111781008138 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781008139 Divergent PAP2 family; Region: DUF212; pfam02681 111781008140 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 111781008141 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 111781008142 substrate binding pocket [chemical binding]; other site 111781008143 chain length determination region; other site 111781008144 substrate-Mg2+ binding site; other site 111781008145 catalytic residues [active] 111781008146 aspartate-rich region 1; other site 111781008147 active site lid residues [active] 111781008148 aspartate-rich region 2; other site 111781008149 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 111781008150 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 111781008151 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 111781008152 active site 111781008153 dimer interface [polypeptide binding]; other site 111781008154 motif 1; other site 111781008155 motif 2; other site 111781008156 motif 3; other site 111781008157 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 111781008158 anticodon binding site; other site 111781008159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781008160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781008161 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 111781008162 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781008163 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 111781008164 substrate binding site [chemical binding]; other site 111781008165 putative lipid kinase; Reviewed; Region: PRK00861 111781008166 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 111781008167 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 111781008168 putative hydrophobic ligand binding site [chemical binding]; other site 111781008169 GTP-binding protein LepA; Provisional; Region: PRK05433 111781008170 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 111781008171 G1 box; other site 111781008172 putative GEF interaction site [polypeptide binding]; other site 111781008173 GTP/Mg2+ binding site [chemical binding]; other site 111781008174 Switch I region; other site 111781008175 G2 box; other site 111781008176 G3 box; other site 111781008177 Switch II region; other site 111781008178 G4 box; other site 111781008179 G5 box; other site 111781008180 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 111781008181 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 111781008182 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 111781008183 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 111781008184 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 111781008185 Walker A/P-loop; other site 111781008186 ATP binding site [chemical binding]; other site 111781008187 Q-loop/lid; other site 111781008188 ABC transporter signature motif; other site 111781008189 Walker B; other site 111781008190 D-loop; other site 111781008191 H-loop/switch region; other site 111781008192 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781008193 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781008194 phosphopeptide binding site; other site 111781008195 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781008196 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781008197 phosphopeptide binding site; other site 111781008198 Transglycosylase; Region: Transgly; pfam00912 111781008199 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 111781008200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 111781008201 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 111781008202 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 111781008203 Domain of unknown function DUF; Region: DUF204; pfam02659 111781008204 TIGR03943 family protein; Region: TIGR03943 111781008205 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 111781008206 PLD-like domain; Region: PLDc_2; pfam13091 111781008207 putative active site [active] 111781008208 catalytic site [active] 111781008209 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 111781008210 PLD-like domain; Region: PLDc_2; pfam13091 111781008211 putative active site [active] 111781008212 catalytic site [active] 111781008213 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 111781008214 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 111781008215 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 111781008216 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 111781008217 active site 111781008218 HIGH motif; other site 111781008219 dimer interface [polypeptide binding]; other site 111781008220 KMSKS motif; other site 111781008221 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 111781008222 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 111781008223 UGMP family protein; Validated; Region: PRK09604 111781008224 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 111781008225 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 111781008226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 111781008227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781008228 dimerization interface [polypeptide binding]; other site 111781008229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781008230 putative active site [active] 111781008231 heme pocket [chemical binding]; other site 111781008232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781008233 dimer interface [polypeptide binding]; other site 111781008234 phosphorylation site [posttranslational modification] 111781008235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008236 ATP binding site [chemical binding]; other site 111781008237 Mg2+ binding site [ion binding]; other site 111781008238 G-X-G motif; other site 111781008239 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 111781008240 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 111781008241 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 111781008242 putative active site [active] 111781008243 putative substrate binding site [chemical binding]; other site 111781008244 putative cosubstrate binding site; other site 111781008245 catalytic site [active] 111781008246 DEAD-like helicases superfamily; Region: DEXDc; smart00487 111781008247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781008248 ATP binding site [chemical binding]; other site 111781008249 putative Mg++ binding site [ion binding]; other site 111781008250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781008251 nucleotide binding region [chemical binding]; other site 111781008252 ATP-binding site [chemical binding]; other site 111781008253 agmatinase; Region: agmatinase; TIGR01230 111781008254 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 111781008255 putative active site [active] 111781008256 Mn binding site [ion binding]; other site 111781008257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781008258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781008259 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 111781008260 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 111781008261 C-terminal domain interface [polypeptide binding]; other site 111781008262 GSH binding site (G-site) [chemical binding]; other site 111781008263 dimer interface [polypeptide binding]; other site 111781008264 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 111781008265 N-terminal domain interface [polypeptide binding]; other site 111781008266 dimer interface [polypeptide binding]; other site 111781008267 substrate binding pocket (H-site) [chemical binding]; other site 111781008268 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781008269 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 111781008270 putative C-terminal domain interface [polypeptide binding]; other site 111781008271 putative GSH binding site (G-site) [chemical binding]; other site 111781008272 putative dimer interface [polypeptide binding]; other site 111781008273 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 111781008274 putative N-terminal domain interface [polypeptide binding]; other site 111781008275 putative dimer interface [polypeptide binding]; other site 111781008276 putative substrate binding pocket (H-site) [chemical binding]; other site 111781008277 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 111781008278 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 111781008279 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 111781008280 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 111781008281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781008282 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 111781008283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781008284 DNA binding residues [nucleotide binding] 111781008285 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 111781008286 nitrilase; Region: PLN02798 111781008287 putative active site [active] 111781008288 catalytic triad [active] 111781008289 dimer interface [polypeptide binding]; other site 111781008290 CpeS-like protein; Region: CpeS; pfam09367 111781008291 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781008292 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008293 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008294 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008295 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008296 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781008297 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781008298 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008300 active site 111781008301 phosphorylation site [posttranslational modification] 111781008302 intermolecular recognition site; other site 111781008303 dimerization interface [polypeptide binding]; other site 111781008304 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781008305 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781008306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008307 dimer interface [polypeptide binding]; other site 111781008308 phosphorylation site [posttranslational modification] 111781008309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008310 ATP binding site [chemical binding]; other site 111781008311 G-X-G motif; other site 111781008312 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008314 active site 111781008315 phosphorylation site [posttranslational modification] 111781008316 intermolecular recognition site; other site 111781008317 dimerization interface [polypeptide binding]; other site 111781008318 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 111781008319 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 111781008320 GTPase RsgA; Reviewed; Region: PRK12289 111781008321 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 111781008322 RNA binding site [nucleotide binding]; other site 111781008323 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 111781008324 GTPase/Zn-binding domain interface [polypeptide binding]; other site 111781008325 GTP/Mg2+ binding site [chemical binding]; other site 111781008326 G4 box; other site 111781008327 G5 box; other site 111781008328 G1 box; other site 111781008329 Switch I region; other site 111781008330 G2 box; other site 111781008331 G3 box; other site 111781008332 Switch II region; other site 111781008333 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 111781008334 CPxP motif; other site 111781008335 chaperone protein DnaJ; Provisional; Region: PRK14293 111781008336 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781008337 HSP70 interaction site [polypeptide binding]; other site 111781008338 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 111781008339 Zn binding sites [ion binding]; other site 111781008340 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 111781008341 dimer interface [polypeptide binding]; other site 111781008342 molecular chaperone DnaK; Provisional; Region: PRK13411 111781008343 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 111781008344 nucleotide binding site [chemical binding]; other site 111781008345 NEF interaction site [polypeptide binding]; other site 111781008346 SBD interface [polypeptide binding]; other site 111781008347 heat shock protein GrpE; Provisional; Region: PRK14140 111781008348 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 111781008349 dimer interface [polypeptide binding]; other site 111781008350 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 111781008351 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 111781008352 Type II/IV secretion system protein; Region: T2SE; pfam00437 111781008353 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 111781008354 Walker A motif; other site 111781008355 ATP binding site [chemical binding]; other site 111781008356 Walker B motif; other site 111781008357 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 111781008358 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 111781008359 Walker A motif; other site 111781008360 ATP binding site [chemical binding]; other site 111781008361 Walker B motif; other site 111781008362 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 111781008363 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 111781008364 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 111781008365 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781008366 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781008367 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 111781008368 Uncharacterized conserved protein [Function unknown]; Region: COG1565 111781008369 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 111781008370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781008371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008372 dimer interface [polypeptide binding]; other site 111781008373 phosphorylation site [posttranslational modification] 111781008374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008375 ATP binding site [chemical binding]; other site 111781008376 Mg2+ binding site [ion binding]; other site 111781008377 G-X-G motif; other site 111781008378 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 111781008379 UbiA prenyltransferase family; Region: UbiA; pfam01040 111781008380 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 111781008381 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 111781008382 putative active site [active] 111781008383 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 111781008384 putative active site [active] 111781008385 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 111781008386 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781008387 cytochrome c-550; Region: PS_II_C550; TIGR03045 111781008388 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 111781008389 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 111781008390 active site 111781008391 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 111781008392 protein binding site [polypeptide binding]; other site 111781008393 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 111781008394 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 111781008395 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781008396 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 111781008397 Caspase domain; Region: Peptidase_C14; pfam00656 111781008398 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781008399 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781008400 polyphosphate kinase; Provisional; Region: PRK05443 111781008401 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 111781008402 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 111781008403 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 111781008404 putative domain interface [polypeptide binding]; other site 111781008405 putative active site [active] 111781008406 catalytic site [active] 111781008407 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 111781008408 putative domain interface [polypeptide binding]; other site 111781008409 putative active site [active] 111781008410 catalytic site [active] 111781008411 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 111781008412 Predicted permeases [General function prediction only]; Region: COG0795 111781008413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781008414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008415 dimer interface [polypeptide binding]; other site 111781008416 phosphorylation site [posttranslational modification] 111781008417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008418 ATP binding site [chemical binding]; other site 111781008419 Mg2+ binding site [ion binding]; other site 111781008420 G-X-G motif; other site 111781008421 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008423 active site 111781008424 phosphorylation site [posttranslational modification] 111781008425 intermolecular recognition site; other site 111781008426 dimerization interface [polypeptide binding]; other site 111781008427 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008429 active site 111781008430 phosphorylation site [posttranslational modification] 111781008431 intermolecular recognition site; other site 111781008432 dimerization interface [polypeptide binding]; other site 111781008433 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 111781008434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781008435 ATP binding site [chemical binding]; other site 111781008436 putative Mg++ binding site [ion binding]; other site 111781008437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781008438 nucleotide binding region [chemical binding]; other site 111781008439 ATP-binding site [chemical binding]; other site 111781008440 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 111781008441 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 111781008442 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 111781008443 nucleotide binding site [chemical binding]; other site 111781008444 gamma-glutamyl kinase; Provisional; Region: PRK05429 111781008445 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 111781008446 nucleotide binding site [chemical binding]; other site 111781008447 homotetrameric interface [polypeptide binding]; other site 111781008448 putative phosphate binding site [ion binding]; other site 111781008449 putative allosteric binding site; other site 111781008450 PUA domain; Region: PUA; pfam01472 111781008451 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 111781008452 transcription termination factor Rho; Provisional; Region: PRK12678 111781008453 YadA-like C-terminal region; Region: YadA; pfam03895 111781008454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781008455 S-adenosylmethionine binding site [chemical binding]; other site 111781008456 NAD synthetase; Provisional; Region: PRK13981 111781008457 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 111781008458 multimer interface [polypeptide binding]; other site 111781008459 active site 111781008460 catalytic triad [active] 111781008461 protein interface 1 [polypeptide binding]; other site 111781008462 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 111781008463 homodimer interface [polypeptide binding]; other site 111781008464 NAD binding pocket [chemical binding]; other site 111781008465 ATP binding pocket [chemical binding]; other site 111781008466 Mg binding site [ion binding]; other site 111781008467 active-site loop [active] 111781008468 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 111781008469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 111781008470 Protein of unknown function, DUF482; Region: DUF482; pfam04339 111781008471 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 111781008472 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 111781008473 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 111781008474 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 111781008475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781008476 Walker A motif; other site 111781008477 ATP binding site [chemical binding]; other site 111781008478 Walker B motif; other site 111781008479 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 111781008480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781008481 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781008482 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781008483 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781008484 phosphopeptide binding site; other site 111781008485 CHASE domain; Region: CHASE; cl01369 111781008486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781008487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008488 dimer interface [polypeptide binding]; other site 111781008489 phosphorylation site [posttranslational modification] 111781008490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008491 ATP binding site [chemical binding]; other site 111781008492 Mg2+ binding site [ion binding]; other site 111781008493 G-X-G motif; other site 111781008494 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008496 active site 111781008497 phosphorylation site [posttranslational modification] 111781008498 intermolecular recognition site; other site 111781008499 dimerization interface [polypeptide binding]; other site 111781008500 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 111781008501 putative binding surface; other site 111781008502 active site 111781008503 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 111781008504 homotrimer interaction site [polypeptide binding]; other site 111781008505 zinc binding site [ion binding]; other site 111781008506 CDP-binding sites; other site 111781008507 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 111781008508 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 111781008509 dimer interface [polypeptide binding]; other site 111781008510 ssDNA binding site [nucleotide binding]; other site 111781008511 tetramer (dimer of dimers) interface [polypeptide binding]; other site 111781008512 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 111781008513 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 111781008514 trmE is a tRNA modification GTPase; Region: trmE; cd04164 111781008515 G1 box; other site 111781008516 GTP/Mg2+ binding site [chemical binding]; other site 111781008517 Switch I region; other site 111781008518 G2 box; other site 111781008519 Switch II region; other site 111781008520 G3 box; other site 111781008521 G4 box; other site 111781008522 G5 box; other site 111781008523 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 111781008524 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 111781008525 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 111781008526 putative active site [active] 111781008527 metal binding site [ion binding]; metal-binding site 111781008528 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 111781008529 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 111781008530 protein binding surface [polypeptide binding]; other site 111781008531 Cache domain; Region: Cache_1; pfam02743 111781008532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781008533 dimerization interface [polypeptide binding]; other site 111781008534 Heme NO binding associated; Region: HNOBA; pfam07701 111781008535 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781008536 cyclase homology domain; Region: CHD; cd07302 111781008537 nucleotidyl binding site; other site 111781008538 metal binding site [ion binding]; metal-binding site 111781008539 dimer interface [polypeptide binding]; other site 111781008540 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 111781008541 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 111781008542 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 111781008543 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 111781008544 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 111781008545 Pheophorbide a oxygenase; Region: PaO; pfam08417 111781008546 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 111781008547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 111781008548 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 111781008549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 111781008550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 111781008551 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 111781008552 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 111781008553 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 111781008554 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 111781008555 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 111781008556 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781008557 active site 111781008558 metal binding site [ion binding]; metal-binding site 111781008559 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 111781008560 active site 111781008561 metal binding site [ion binding]; metal-binding site 111781008562 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 111781008563 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 111781008564 active site 111781008565 (T/H)XGH motif; other site 111781008566 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 111781008567 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 111781008568 ATP binding site [chemical binding]; other site 111781008569 active site 111781008570 substrate binding site [chemical binding]; other site 111781008571 chloroplast envelope protein translocase, IAP75 family; Region: 3a0901s03IAP75; TIGR00992 111781008572 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 111781008573 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 111781008574 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781008575 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 111781008576 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 111781008577 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 111781008578 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 111781008579 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 111781008580 dimer interface [polypeptide binding]; other site 111781008581 decamer (pentamer of dimers) interface [polypeptide binding]; other site 111781008582 catalytic triad [active] 111781008583 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 111781008584 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 111781008585 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 111781008586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781008587 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781008588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781008589 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781008590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781008591 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781008592 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 111781008593 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 111781008594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781008595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 111781008596 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 111781008597 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 111781008598 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 111781008599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781008600 Homeodomain-like domain; Region: HTH_32; pfam13565 111781008601 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781008602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781008603 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 111781008604 putative active site [active] 111781008605 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 111781008606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 111781008607 active site 111781008608 catalytic tetrad [active] 111781008609 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 111781008610 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781008611 active site 111781008612 metal binding site [ion binding]; metal-binding site 111781008613 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 111781008614 Conserved TM helix; Region: TM_helix; pfam05552 111781008615 Conserved TM helix; Region: TM_helix; pfam05552 111781008616 Conserved TM helix; Region: TM_helix; pfam05552 111781008617 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 111781008618 hydrophobic ligand binding site; other site 111781008619 hypothetical protein; Provisional; Region: PRK13683 111781008620 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 111781008621 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 111781008622 Walker A/P-loop; other site 111781008623 ATP binding site [chemical binding]; other site 111781008624 Q-loop/lid; other site 111781008625 ABC transporter signature motif; other site 111781008626 Walker B; other site 111781008627 D-loop; other site 111781008628 H-loop/switch region; other site 111781008629 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 111781008630 trimer interface [polypeptide binding]; other site 111781008631 active site 111781008632 phosphodiesterase; Provisional; Region: PRK12704 111781008633 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 111781008634 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 111781008635 Transcriptional activator [Transcription]; Region: ChrR; COG3806 111781008636 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 111781008637 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 111781008638 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 111781008639 classical (c) SDRs; Region: SDR_c; cd05233 111781008640 NAD(P) binding site [chemical binding]; other site 111781008641 active site 111781008642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781008643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781008644 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781008645 peptide synthase; Provisional; Region: PRK09274 111781008646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 111781008647 acyl-activating enzyme (AAE) consensus motif; other site 111781008648 AMP binding site [chemical binding]; other site 111781008649 active site 111781008650 CoA binding site [chemical binding]; other site 111781008651 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781008652 cyclase homology domain; Region: CHD; cd07302 111781008653 nucleotidyl binding site; other site 111781008654 metal binding site [ion binding]; metal-binding site 111781008655 dimer interface [polypeptide binding]; other site 111781008656 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 111781008657 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 111781008658 hexamer interface [polypeptide binding]; other site 111781008659 ligand binding site [chemical binding]; other site 111781008660 putative active site [active] 111781008661 NAD(P) binding site [chemical binding]; other site 111781008662 TPR repeat; Region: TPR_11; pfam13414 111781008663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781008664 binding surface 111781008665 TPR repeat; Region: TPR_11; pfam13414 111781008666 TPR motif; other site 111781008667 TPR repeat; Region: TPR_11; pfam13414 111781008668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781008669 binding surface 111781008670 TPR motif; other site 111781008671 TPR repeat; Region: TPR_11; pfam13414 111781008672 Caspase domain; Region: Peptidase_C14; pfam00656 111781008673 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781008674 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781008675 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 111781008676 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 111781008677 active site 111781008678 DNA binding site [nucleotide binding] 111781008679 Int/Topo IB signature motif; other site 111781008680 NB-ARC domain; Region: NB-ARC; pfam00931 111781008681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781008682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781008683 binding surface 111781008684 TPR motif; other site 111781008685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781008686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781008687 binding surface 111781008688 TPR motif; other site 111781008689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781008690 non-specific DNA binding site [nucleotide binding]; other site 111781008691 salt bridge; other site 111781008692 sequence-specific DNA binding site [nucleotide binding]; other site 111781008693 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 111781008694 active site 111781008695 metal binding site [ion binding]; metal-binding site 111781008696 interdomain interaction site; other site 111781008697 Virulence-associated protein E; Region: VirE; pfam05272 111781008698 Predicted ATPase [General function prediction only]; Region: COG5293 111781008699 GAF domain; Region: GAF_3; pfam13492 111781008700 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781008701 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 111781008702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781008703 putative active site [active] 111781008704 heme pocket [chemical binding]; other site 111781008705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008706 ATP binding site [chemical binding]; other site 111781008707 Mg2+ binding site [ion binding]; other site 111781008708 G-X-G motif; other site 111781008709 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 111781008710 oligomer interface [polypeptide binding]; other site 111781008711 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 111781008712 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 111781008713 putative active site [active] 111781008714 substrate binding site [chemical binding]; other site 111781008715 putative cosubstrate binding site; other site 111781008716 catalytic site [active] 111781008717 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 111781008718 substrate binding site [chemical binding]; other site 111781008719 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 111781008720 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 111781008721 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 111781008722 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 111781008723 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 111781008724 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 111781008725 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 111781008726 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 111781008727 hinge; other site 111781008728 active site 111781008729 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 111781008730 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 111781008731 CHAT domain; Region: CHAT; cl17868 111781008732 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781008733 CHASE2 domain; Region: CHASE2; pfam05226 111781008734 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781008735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781008736 metal binding site [ion binding]; metal-binding site 111781008737 active site 111781008738 I-site; other site 111781008739 GXWXG protein; Region: GXWXG; pfam14231 111781008740 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 111781008741 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781008742 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 111781008743 active site 111781008744 metal binding site [ion binding]; metal-binding site 111781008745 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 111781008746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 111781008747 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 111781008748 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 111781008749 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 111781008750 trimer interface [polypeptide binding]; other site 111781008751 active site 111781008752 substrate binding site [chemical binding]; other site 111781008753 CoA binding site [chemical binding]; other site 111781008754 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 111781008755 putative binding surface; other site 111781008756 active site 111781008757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781008758 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781008759 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 111781008760 diiron binding motif [ion binding]; other site 111781008761 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781008762 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781008763 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781008764 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781008765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781008766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008767 dimer interface [polypeptide binding]; other site 111781008768 phosphorylation site [posttranslational modification] 111781008769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008770 ATP binding site [chemical binding]; other site 111781008771 Mg2+ binding site [ion binding]; other site 111781008772 G-X-G motif; other site 111781008773 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781008774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008775 active site 111781008776 phosphorylation site [posttranslational modification] 111781008777 intermolecular recognition site; other site 111781008778 dimerization interface [polypeptide binding]; other site 111781008779 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781008780 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781008781 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781008782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781008783 metal binding site [ion binding]; metal-binding site 111781008784 active site 111781008785 I-site; other site 111781008786 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 111781008787 putative active site [active] 111781008788 catalytic residue [active] 111781008789 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 111781008790 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 111781008791 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781008792 iron-sulfur cluster [ion binding]; other site 111781008793 [2Fe-2S] cluster binding site [ion binding]; other site 111781008794 CpeS-like protein; Region: CpeS; pfam09367 111781008795 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008797 active site 111781008798 phosphorylation site [posttranslational modification] 111781008799 intermolecular recognition site; other site 111781008800 dimerization interface [polypeptide binding]; other site 111781008801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 111781008802 dimer interface [polypeptide binding]; other site 111781008803 phosphorylation site [posttranslational modification] 111781008804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008805 ATP binding site [chemical binding]; other site 111781008806 Mg2+ binding site [ion binding]; other site 111781008807 G-X-G motif; other site 111781008808 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 111781008809 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 111781008810 Uncharacterized conserved protein [Function unknown]; Region: COG4279 111781008811 SWIM zinc finger; Region: SWIM; pfam04434 111781008812 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 111781008813 Cache domain; Region: Cache_1; pfam02743 111781008814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781008815 dimerization interface [polypeptide binding]; other site 111781008816 PAS fold; Region: PAS_4; pfam08448 111781008817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781008818 putative active site [active] 111781008819 heme pocket [chemical binding]; other site 111781008820 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781008821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781008822 metal binding site [ion binding]; metal-binding site 111781008823 active site 111781008824 I-site; other site 111781008825 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781008826 membrane protein; Provisional; Region: PRK14419 111781008827 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 111781008828 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 111781008829 GTP-binding protein YchF; Reviewed; Region: PRK09601 111781008830 YchF GTPase; Region: YchF; cd01900 111781008831 G1 box; other site 111781008832 GTP/Mg2+ binding site [chemical binding]; other site 111781008833 Switch I region; other site 111781008834 G2 box; other site 111781008835 Switch II region; other site 111781008836 G3 box; other site 111781008837 G4 box; other site 111781008838 G5 box; other site 111781008839 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 111781008840 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781008841 active site 111781008842 ATP binding site [chemical binding]; other site 111781008843 substrate binding site [chemical binding]; other site 111781008844 activation loop (A-loop); other site 111781008845 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781008846 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781008847 structural tetrad; other site 111781008848 CAAX protease self-immunity; Region: Abi; pfam02517 111781008849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781008850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 111781008851 putative substrate translocation pore; other site 111781008852 HEAT repeats; Region: HEAT_2; pfam13646 111781008853 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781008854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781008855 ligand binding site [chemical binding]; other site 111781008856 flexible hinge region; other site 111781008857 carboxyl-terminal processing protease; Provisional; Region: PLN00049 111781008858 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 111781008859 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 111781008860 protein binding site [polypeptide binding]; other site 111781008861 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 111781008862 Catalytic dyad [active] 111781008863 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 111781008864 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 111781008865 Qi binding site; other site 111781008866 intrachain domain interface; other site 111781008867 interchain domain interface [polypeptide binding]; other site 111781008868 heme bH binding site [chemical binding]; other site 111781008869 heme bL binding site [chemical binding]; other site 111781008870 Qo binding site; other site 111781008871 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 111781008872 interchain domain interface [polypeptide binding]; other site 111781008873 intrachain domain interface; other site 111781008874 Qi binding site; other site 111781008875 Qo binding site; other site 111781008876 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781008877 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781008878 PAS domain S-box; Region: sensory_box; TIGR00229 111781008879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781008880 putative active site [active] 111781008881 heme pocket [chemical binding]; other site 111781008882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008883 dimer interface [polypeptide binding]; other site 111781008884 phosphorylation site [posttranslational modification] 111781008885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008886 ATP binding site [chemical binding]; other site 111781008887 Mg2+ binding site [ion binding]; other site 111781008888 G-X-G motif; other site 111781008889 Peptidase M15; Region: Peptidase_M15_3; cl01194 111781008890 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 111781008891 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 111781008892 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 111781008893 dimerization interface [polypeptide binding]; other site 111781008894 active site 111781008895 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 111781008896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781008897 ATP binding site [chemical binding]; other site 111781008898 putative Mg++ binding site [ion binding]; other site 111781008899 helicase superfamily c-terminal domain; Region: HELICc; smart00490 111781008900 ATP-binding site [chemical binding]; other site 111781008901 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 111781008902 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 111781008903 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781008904 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 111781008905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781008906 DNA binding residues [nucleotide binding] 111781008907 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 111781008908 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 111781008909 metal-binding site [ion binding] 111781008910 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 111781008911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781008912 motif II; other site 111781008913 Predicted integral membrane protein [Function unknown]; Region: COG0392 111781008914 Bacterial SH3 domain; Region: SH3_3; cl17532 111781008915 Ycf46; Provisional; Region: ycf46; CHL00195 111781008916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781008917 Walker A motif; other site 111781008918 ATP binding site [chemical binding]; other site 111781008919 Walker B motif; other site 111781008920 arginine finger; other site 111781008921 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 111781008922 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 111781008923 G-X-X-G motif; other site 111781008924 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 111781008925 RxxxH motif; other site 111781008926 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 111781008927 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 111781008928 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 111781008929 Bacterial PH domain; Region: DUF304; pfam03703 111781008930 ribonuclease P; Reviewed; Region: rnpA; PRK03031 111781008931 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 111781008932 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 111781008933 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 111781008934 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 111781008935 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 111781008936 ligand binding site [chemical binding]; other site 111781008937 homodimer interface [polypeptide binding]; other site 111781008938 NAD(P) binding site [chemical binding]; other site 111781008939 trimer interface B [polypeptide binding]; other site 111781008940 trimer interface A [polypeptide binding]; other site 111781008941 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 111781008942 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 111781008943 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 111781008944 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 111781008945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781008946 dimerization interface [polypeptide binding]; other site 111781008947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008948 dimer interface [polypeptide binding]; other site 111781008949 phosphorylation site [posttranslational modification] 111781008950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008951 ATP binding site [chemical binding]; other site 111781008952 Mg2+ binding site [ion binding]; other site 111781008953 G-X-G motif; other site 111781008954 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781008955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008956 active site 111781008957 phosphorylation site [posttranslational modification] 111781008958 intermolecular recognition site; other site 111781008959 dimerization interface [polypeptide binding]; other site 111781008960 Response regulator receiver domain; Region: Response_reg; pfam00072 111781008961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781008962 active site 111781008963 phosphorylation site [posttranslational modification] 111781008964 intermolecular recognition site; other site 111781008965 dimerization interface [polypeptide binding]; other site 111781008966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781008967 dimer interface [polypeptide binding]; other site 111781008968 phosphorylation site [posttranslational modification] 111781008969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781008970 ATP binding site [chemical binding]; other site 111781008971 Mg2+ binding site [ion binding]; other site 111781008972 G-X-G motif; other site 111781008973 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 111781008974 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 111781008975 GIY-YIG motif/motif A; other site 111781008976 active site 111781008977 catalytic site [active] 111781008978 putative DNA binding site [nucleotide binding]; other site 111781008979 metal binding site [ion binding]; metal-binding site 111781008980 UvrB/uvrC motif; Region: UVR; pfam02151 111781008981 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 111781008982 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 111781008983 Caspase domain; Region: Peptidase_C14; pfam00656 111781008984 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781008985 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781008986 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781008987 HSP70 interaction site [polypeptide binding]; other site 111781008988 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 111781008989 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 111781008990 Lumazine binding domain; Region: Lum_binding; pfam00677 111781008991 Lumazine binding domain; Region: Lum_binding; pfam00677 111781008992 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 111781008993 thiS-thiF/thiG interaction site; other site 111781008994 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 111781008995 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 111781008996 thiamine phosphate binding site [chemical binding]; other site 111781008997 active site 111781008998 pyrophosphate binding site [ion binding]; other site 111781008999 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 111781009000 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 111781009001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781009002 FeS/SAM binding site; other site 111781009003 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 111781009004 Ligand Binding Site [chemical binding]; other site 111781009005 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 111781009006 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 111781009007 iron-sulfur cluster [ion binding]; other site 111781009008 [2Fe-2S] cluster binding site [ion binding]; other site 111781009009 Response regulator receiver domain; Region: Response_reg; pfam00072 111781009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 111781009011 phosphorylation site [posttranslational modification] 111781009012 intermolecular recognition site; other site 111781009013 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 111781009014 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 111781009015 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 111781009016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781009017 dimer interface [polypeptide binding]; other site 111781009018 conserved gate region; other site 111781009019 ABC-ATPase subunit interface; other site 111781009020 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 111781009021 tetramer interface [polypeptide binding]; other site 111781009022 dimer interface [polypeptide binding]; other site 111781009023 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 111781009024 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 111781009025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781009026 catalytic residue [active] 111781009027 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 111781009028 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 111781009029 substrate binding site [chemical binding]; other site 111781009030 ligand binding site [chemical binding]; other site 111781009031 Response regulator receiver domain; Region: Response_reg; pfam00072 111781009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781009033 active site 111781009034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781009035 phosphorylation site [posttranslational modification] 111781009036 intermolecular recognition site; other site 111781009037 dimerization interface [polypeptide binding]; other site 111781009038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781009039 dimer interface [polypeptide binding]; other site 111781009040 phosphorylation site [posttranslational modification] 111781009041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009042 ATP binding site [chemical binding]; other site 111781009043 Mg2+ binding site [ion binding]; other site 111781009044 G-X-G motif; other site 111781009045 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781009046 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781009047 structural tetrad; other site 111781009048 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781009049 GAF domain; Region: GAF; pfam01590 111781009050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781009051 PAS domain; Region: PAS_9; pfam13426 111781009052 putative active site [active] 111781009053 heme pocket [chemical binding]; other site 111781009054 PAS domain S-box; Region: sensory_box; TIGR00229 111781009055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781009056 putative active site [active] 111781009057 heme pocket [chemical binding]; other site 111781009058 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781009059 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009060 metal binding site [ion binding]; metal-binding site 111781009061 active site 111781009062 I-site; other site 111781009063 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781009064 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 111781009065 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 111781009066 putative acyl-acceptor binding pocket; other site 111781009067 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 111781009068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 111781009069 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 111781009070 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 111781009071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781009072 motif II; other site 111781009073 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 111781009074 protein I interface; other site 111781009075 D2 interface; other site 111781009076 protein T interface; other site 111781009077 chlorophyll binding site; other site 111781009078 beta carotene binding site; other site 111781009079 pheophytin binding site; other site 111781009080 manganese-stabilizing polypeptide interface; other site 111781009081 CP43 interface; other site 111781009082 protein L interface; other site 111781009083 oxygen evolving complex binding site; other site 111781009084 bromide binding site; other site 111781009085 quinone binding site; other site 111781009086 Fe binding site [ion binding]; other site 111781009087 core light harvesting interface; other site 111781009088 cytochrome b559 alpha subunit interface; other site 111781009089 cytochrome c-550 interface; other site 111781009090 protein J interface; other site 111781009091 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 111781009092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781009093 FeS/SAM binding site; other site 111781009094 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 111781009095 active site 111781009096 catalytic triad [active] 111781009097 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 111781009098 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 111781009099 NifU-like domain; Region: NifU; pfam01106 111781009100 HEAT repeats; Region: HEAT_2; pfam13646 111781009101 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 111781009102 HEAT repeats; Region: HEAT_2; pfam13646 111781009103 Phycobilisome protein; Region: Phycobilisome; cl08227 111781009104 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 111781009105 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 111781009106 ring oligomerisation interface [polypeptide binding]; other site 111781009107 ATP/Mg binding site [chemical binding]; other site 111781009108 stacking interactions; other site 111781009109 hinge regions; other site 111781009110 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 111781009111 oligomerisation interface [polypeptide binding]; other site 111781009112 mobile loop; other site 111781009113 roof hairpin; other site 111781009114 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 111781009115 iron-sulfur cluster [ion binding]; other site 111781009116 [2Fe-2S] cluster binding site [ion binding]; other site 111781009117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781009118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781009119 Coenzyme A binding pocket [chemical binding]; other site 111781009120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781009121 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781009122 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 111781009123 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 111781009124 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781009125 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 111781009126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 111781009127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781009128 homodimer interface [polypeptide binding]; other site 111781009129 catalytic residue [active] 111781009130 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 111781009131 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 111781009132 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 111781009133 Uncharacterized conserved protein [Function unknown]; Region: COG0393 111781009134 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781009135 GAF domain; Region: GAF; pfam01590 111781009136 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 111781009137 dimer interface [polypeptide binding]; other site 111781009138 phosphorylation site [posttranslational modification] 111781009139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009140 ATP binding site [chemical binding]; other site 111781009141 Mg2+ binding site [ion binding]; other site 111781009142 G-X-G motif; other site 111781009143 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 111781009144 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 111781009145 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 111781009146 active site 111781009147 Peptidase family M50; Region: Peptidase_M50; pfam02163 111781009148 putative substrate binding region [chemical binding]; other site 111781009149 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 111781009150 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 111781009151 IHF dimer interface [polypeptide binding]; other site 111781009152 IHF - DNA interface [nucleotide binding]; other site 111781009153 Domain of unknown function DUF20; Region: UPF0118; pfam01594 111781009154 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 111781009155 K-Cl cotransporter; Region: 2a30; TIGR00930 111781009156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781009157 dimer interface [polypeptide binding]; other site 111781009158 phosphorylation site [posttranslational modification] 111781009159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009160 ATP binding site [chemical binding]; other site 111781009161 Mg2+ binding site [ion binding]; other site 111781009162 G-X-G motif; other site 111781009163 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 111781009164 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 111781009165 ABC1 family; Region: ABC1; pfam03109 111781009166 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 111781009167 active site 111781009168 ATP binding site [chemical binding]; other site 111781009169 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 111781009170 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 111781009171 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 111781009172 trimer interface [polypeptide binding]; other site 111781009173 active site 111781009174 substrate binding site [chemical binding]; other site 111781009175 CoA binding site [chemical binding]; other site 111781009176 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 111781009177 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 111781009178 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 111781009179 active site 111781009180 ATP binding site [chemical binding]; other site 111781009181 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 111781009182 GSH binding site [chemical binding]; other site 111781009183 catalytic residues [active] 111781009184 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 111781009185 Acyltransferase family; Region: Acyl_transf_3; pfam01757 111781009186 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 111781009187 MoaE interaction surface [polypeptide binding]; other site 111781009188 MoeB interaction surface [polypeptide binding]; other site 111781009189 thiocarboxylated glycine; other site 111781009190 threonine synthase; Validated; Region: PRK07591 111781009191 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 111781009192 homodimer interface [polypeptide binding]; other site 111781009193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781009194 catalytic residue [active] 111781009195 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781009196 CHASE2 domain; Region: CHASE2; pfam05226 111781009197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781009198 dimer interface [polypeptide binding]; other site 111781009199 phosphorylation site [posttranslational modification] 111781009200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009201 ATP binding site [chemical binding]; other site 111781009202 Mg2+ binding site [ion binding]; other site 111781009203 G-X-G motif; other site 111781009204 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009206 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781009207 HSP70 interaction site [polypeptide binding]; other site 111781009208 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 111781009209 substrate binding site [polypeptide binding]; other site 111781009210 dimer interface [polypeptide binding]; other site 111781009211 thiamine monophosphate kinase; Provisional; Region: PRK05731 111781009212 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 111781009213 ATP binding site [chemical binding]; other site 111781009214 dimerization interface [polypeptide binding]; other site 111781009215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 111781009216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781009217 dimer interface [polypeptide binding]; other site 111781009218 conserved gate region; other site 111781009219 putative PBP binding loops; other site 111781009220 ABC-ATPase subunit interface; other site 111781009221 DNA polymerase III subunit delta'; Validated; Region: PRK07399 111781009222 DNA polymerase III subunit delta'; Validated; Region: PRK08485 111781009223 Psb28 protein; Region: Psb28; cl04326 111781009224 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 111781009225 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 111781009226 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 111781009227 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 111781009228 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 111781009229 Beta/Gamma crystallin; Region: Crystall; cl02528 111781009230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781009231 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781009232 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781009233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781009234 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 111781009235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009236 DDE superfamily endonuclease; Region: DDE_4; pfam13359 111781009237 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009238 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009239 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 111781009240 OstA-like protein; Region: OstA; cl00844 111781009241 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 111781009242 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 111781009243 lipoyl attachment site [posttranslational modification]; other site 111781009244 proline aminopeptidase P II; Provisional; Region: PRK10879 111781009245 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 111781009246 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 111781009247 active site 111781009248 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 111781009249 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 111781009250 tetramer interface [polypeptide binding]; other site 111781009251 TPP-binding site [chemical binding]; other site 111781009252 heterodimer interface [polypeptide binding]; other site 111781009253 phosphorylation loop region [posttranslational modification] 111781009254 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781009255 HSP70 interaction site [polypeptide binding]; other site 111781009256 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 111781009257 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 111781009258 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 111781009259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781009260 Phycobilisome protein; Region: Phycobilisome; cl08227 111781009261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781009262 PAS domain; Region: PAS_9; pfam13426 111781009263 putative active site [active] 111781009264 heme pocket [chemical binding]; other site 111781009265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781009266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009267 metal binding site [ion binding]; metal-binding site 111781009268 active site 111781009269 I-site; other site 111781009270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781009271 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 111781009272 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781009273 glutathione synthetase; Provisional; Region: PRK05246 111781009274 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 111781009275 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 111781009276 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 111781009277 DHH family; Region: DHH; pfam01368 111781009278 hypothetical protein; Provisional; Region: PRK13686 111781009279 Flagellin N-methylase; Region: FliB; pfam03692 111781009280 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 111781009281 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 111781009282 active site 111781009283 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 111781009284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 111781009285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 111781009286 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 111781009287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781009288 motif II; other site 111781009289 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 111781009290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781009291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781009292 TPR motif; other site 111781009293 binding surface 111781009294 TPR repeat; Region: TPR_11; pfam13414 111781009295 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 111781009296 signal recognition particle protein; Provisional; Region: PRK10867 111781009297 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 111781009298 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 111781009299 P loop; other site 111781009300 GTP binding site [chemical binding]; other site 111781009301 Signal peptide binding domain; Region: SRP_SPB; pfam02978 111781009302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781009303 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781009304 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 111781009305 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 111781009306 Mg++ binding site [ion binding]; other site 111781009307 putative catalytic motif [active] 111781009308 substrate binding site [chemical binding]; other site 111781009309 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 111781009310 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 111781009311 dimer interface [polypeptide binding]; other site 111781009312 active site 111781009313 glycine-pyridoxal phosphate binding site [chemical binding]; other site 111781009314 folate binding site [chemical binding]; other site 111781009315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009316 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009317 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781009318 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009319 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009321 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009322 Transglycosylase; Region: Transgly; pfam00912 111781009323 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 111781009324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 111781009325 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 111781009326 Cytochrome c; Region: Cytochrom_C; pfam00034 111781009327 C factor cell-cell signaling protein; Provisional; Region: PRK09009 111781009328 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 111781009329 NADP binding site [chemical binding]; other site 111781009330 homodimer interface [polypeptide binding]; other site 111781009331 active site 111781009332 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 111781009333 dimer interface [polypeptide binding]; other site 111781009334 catalytic triad [active] 111781009335 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 111781009336 triosephosphate isomerase; Provisional; Region: PRK14565 111781009337 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 111781009338 substrate binding site [chemical binding]; other site 111781009339 dimer interface [polypeptide binding]; other site 111781009340 catalytic triad [active] 111781009341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781009342 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 111781009343 Walker A motif; other site 111781009344 ATP binding site [chemical binding]; other site 111781009345 Walker B motif; other site 111781009346 arginine finger; other site 111781009347 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 111781009348 metal ion-dependent adhesion site (MIDAS); other site 111781009349 spermine synthase; Region: PLN02823 111781009350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781009351 S-adenosylmethionine binding site [chemical binding]; other site 111781009352 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 111781009353 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 111781009354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 111781009355 catalytic loop [active] 111781009356 iron binding site [ion binding]; other site 111781009357 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 111781009358 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 111781009359 active site 111781009360 dimerization interface [polypeptide binding]; other site 111781009361 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 111781009362 HSP70 interaction site [polypeptide binding]; other site 111781009363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781009364 TPR repeat; Region: TPR_11; pfam13414 111781009365 TPR motif; other site 111781009366 binding surface 111781009367 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 111781009368 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 111781009369 dimer interface [polypeptide binding]; other site 111781009370 motif 1; other site 111781009371 active site 111781009372 motif 2; other site 111781009373 motif 3; other site 111781009374 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 111781009375 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 111781009376 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 111781009377 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 111781009378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 111781009379 FeS/SAM binding site; other site 111781009380 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 111781009381 DEAD-like helicases superfamily; Region: DEXDc; smart00487 111781009382 ATP binding site [chemical binding]; other site 111781009383 Mg++ binding site [ion binding]; other site 111781009384 motif III; other site 111781009385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781009386 nucleotide binding region [chemical binding]; other site 111781009387 ATP-binding site [chemical binding]; other site 111781009388 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781009389 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781009390 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781009391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781009392 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009393 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781009395 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 111781009396 dimer interface [polypeptide binding]; other site 111781009397 active site 111781009398 metal binding site [ion binding]; metal-binding site 111781009399 glutathione binding site [chemical binding]; other site 111781009400 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 111781009401 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 111781009402 homodimer interface [polypeptide binding]; other site 111781009403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781009404 catalytic residue [active] 111781009405 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 111781009406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 111781009407 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 111781009408 YacP-like NYN domain; Region: NYN_YacP; pfam05991 111781009409 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 111781009410 Nitrogen regulatory protein P-II; Region: P-II; smart00938 111781009411 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 111781009412 active site 111781009413 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 111781009414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781009415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781009416 NAD(P) binding site [chemical binding]; other site 111781009417 active site 111781009418 CpeS-like protein; Region: CpeS; pfam09367 111781009419 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 111781009420 16S/18S rRNA binding site [nucleotide binding]; other site 111781009421 S13e-L30e interaction site [polypeptide binding]; other site 111781009422 25S rRNA binding site [nucleotide binding]; other site 111781009423 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 111781009424 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 111781009425 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 111781009426 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 111781009427 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 111781009428 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 111781009429 ThiS interaction site; other site 111781009430 putative active site [active] 111781009431 tetramer interface [polypeptide binding]; other site 111781009432 glycogen branching enzyme; Provisional; Region: PRK05402 111781009433 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 111781009434 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 111781009435 active site 111781009436 catalytic site [active] 111781009437 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 111781009438 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 111781009439 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 111781009440 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 111781009441 homodimer interface [polypeptide binding]; other site 111781009442 substrate-cofactor binding pocket; other site 111781009443 catalytic residue [active] 111781009444 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 111781009445 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 111781009446 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 111781009447 protein binding site [polypeptide binding]; other site 111781009448 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781009449 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781009450 ligand binding site [chemical binding]; other site 111781009451 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 111781009452 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 111781009453 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 111781009454 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 111781009455 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 111781009456 catalytic center binding site [active] 111781009457 ATP binding site [chemical binding]; other site 111781009458 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 111781009459 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 111781009460 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 111781009461 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 111781009462 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 111781009463 putative dimer interface [polypeptide binding]; other site 111781009464 putative anticodon binding site; other site 111781009465 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 111781009466 homodimer interface [polypeptide binding]; other site 111781009467 motif 1; other site 111781009468 motif 2; other site 111781009469 active site 111781009470 motif 3; other site 111781009471 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 111781009472 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 111781009473 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 111781009474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781009475 Homeodomain-like domain; Region: HTH_32; pfam13565 111781009476 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781009477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781009478 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 111781009479 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 111781009480 putative ligand binding site [chemical binding]; other site 111781009481 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 111781009482 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 111781009483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781009484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781009485 dimer interface [polypeptide binding]; other site 111781009486 phosphorylation site [posttranslational modification] 111781009487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009488 ATP binding site [chemical binding]; other site 111781009489 Mg2+ binding site [ion binding]; other site 111781009490 G-X-G motif; other site 111781009491 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 111781009492 Glycoprotease family; Region: Peptidase_M22; pfam00814 111781009493 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 111781009494 Phosphotransferase enzyme family; Region: APH; pfam01636 111781009495 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 111781009496 active site 111781009497 ATP binding site [chemical binding]; other site 111781009498 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 111781009499 substrate binding site [chemical binding]; other site 111781009500 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 111781009501 dimer interface [polypeptide binding]; other site 111781009502 motif 1; other site 111781009503 active site 111781009504 motif 2; other site 111781009505 motif 3; other site 111781009506 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 111781009507 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 111781009508 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 111781009509 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 111781009510 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 111781009511 dimerization interface [polypeptide binding]; other site 111781009512 active site 111781009513 metal binding site [ion binding]; metal-binding site 111781009514 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781009515 anti sigma factor interaction site; other site 111781009516 regulatory phosphorylation site [posttranslational modification]; other site 111781009517 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 111781009518 dimer interface [polypeptide binding]; other site 111781009519 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 111781009520 putative radical transfer pathway; other site 111781009521 diiron center [ion binding]; other site 111781009522 tyrosyl radical; other site 111781009523 light-harvesting-like protein 3; Provisional; Region: PLN00014 111781009524 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 111781009525 active site 111781009526 dimerization interface [polypeptide binding]; other site 111781009527 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 111781009528 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 111781009529 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781009530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009531 metal binding site [ion binding]; metal-binding site 111781009532 active site 111781009533 I-site; other site 111781009534 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781009535 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009536 metal binding site [ion binding]; metal-binding site 111781009537 active site 111781009538 I-site; other site 111781009539 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 111781009540 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 111781009541 Protein of unknown function, DUF608; Region: DUF608; pfam04685 111781009542 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781009543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781009544 Cache domain; Region: Cache_1; pfam02743 111781009545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781009546 dimerization interface [polypeptide binding]; other site 111781009547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781009548 dimer interface [polypeptide binding]; other site 111781009549 phosphorylation site [posttranslational modification] 111781009550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009551 ATP binding site [chemical binding]; other site 111781009552 Mg2+ binding site [ion binding]; other site 111781009553 G-X-G motif; other site 111781009554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781009555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781009556 active site 111781009557 phosphorylation site [posttranslational modification] 111781009558 intermolecular recognition site; other site 111781009559 dimerization interface [polypeptide binding]; other site 111781009560 cyclase homology domain; Region: CHD; cd07302 111781009561 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781009562 nucleotidyl binding site; other site 111781009563 metal binding site [ion binding]; metal-binding site 111781009564 dimer interface [polypeptide binding]; other site 111781009565 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 111781009566 Abortive infection C-terminus; Region: Abi_C; pfam14355 111781009567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 111781009568 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 111781009569 Uncharacterized conserved protein [Function unknown]; Region: COG2968 111781009570 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 111781009571 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 111781009572 Bacterial sugar transferase; Region: Bac_transf; pfam02397 111781009573 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 111781009574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781009575 putative ADP-binding pocket [chemical binding]; other site 111781009576 Uncharacterized conserved protein [Function unknown]; Region: COG2006 111781009577 Domain of unknown function (DUF362); Region: DUF362; pfam04015 111781009578 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 111781009579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781009580 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 111781009581 Predicted membrane protein [Function unknown]; Region: COG3431 111781009582 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 111781009583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781009584 hypothetical protein; Region: PHA02135 111781009585 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 111781009586 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 111781009587 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 111781009588 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 111781009589 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 111781009590 TM-ABC transporter signature motif; other site 111781009591 high affinity sulphate transporter 1; Region: sulP; TIGR00815 111781009592 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 111781009593 Sulfate transporter family; Region: Sulfate_transp; pfam00916 111781009594 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 111781009595 S-layer homology domain; Region: SLH; pfam00395 111781009596 Syntaxin 6, N-terminal; Region: Syntaxin-6_N; pfam09177 111781009597 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 111781009598 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 111781009599 KilA-N domain; Region: KilA-N; pfam04383 111781009600 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 111781009601 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 111781009602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 111781009603 SnoaL-like domain; Region: SnoaL_2; pfam12680 111781009604 Methyltransferase domain; Region: Methyltransf_23; pfam13489 111781009605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781009606 S-adenosylmethionine binding site [chemical binding]; other site 111781009607 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 111781009608 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 111781009609 homodimer interface [polypeptide binding]; other site 111781009610 substrate-cofactor binding pocket; other site 111781009611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781009612 catalytic residue [active] 111781009613 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 111781009614 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 111781009615 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 111781009616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 111781009617 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 111781009618 acyl-activating enzyme (AAE) consensus motif; other site 111781009619 putative AMP binding site [chemical binding]; other site 111781009620 putative active site [active] 111781009621 putative CoA binding site [chemical binding]; other site 111781009622 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 111781009623 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 111781009624 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 111781009625 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 111781009626 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 111781009627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 111781009628 substrate binding site [chemical binding]; other site 111781009629 oxyanion hole (OAH) forming residues; other site 111781009630 trimer interface [polypeptide binding]; other site 111781009631 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 111781009632 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 111781009633 dimer interface [polypeptide binding]; other site 111781009634 active site 111781009635 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 111781009636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 111781009637 active site 111781009638 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 111781009639 cyanate hydratase; Validated; Region: PRK02866 111781009640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 111781009641 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 111781009642 oligomer interface [polypeptide binding]; other site 111781009643 active site 111781009644 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 111781009645 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 111781009646 Walker A/P-loop; other site 111781009647 ATP binding site [chemical binding]; other site 111781009648 Q-loop/lid; other site 111781009649 ABC transporter signature motif; other site 111781009650 Walker B; other site 111781009651 D-loop; other site 111781009652 H-loop/switch region; other site 111781009653 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 111781009654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781009655 dimer interface [polypeptide binding]; other site 111781009656 conserved gate region; other site 111781009657 putative PBP binding loops; other site 111781009658 ABC-ATPase subunit interface; other site 111781009659 NMT1-like family; Region: NMT1_2; pfam13379 111781009660 NMT1/THI5 like; Region: NMT1; pfam09084 111781009661 Response regulator receiver domain; Region: Response_reg; pfam00072 111781009662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781009663 active site 111781009664 phosphorylation site [posttranslational modification] 111781009665 intermolecular recognition site; other site 111781009666 dimerization interface [polypeptide binding]; other site 111781009667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 111781009668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 111781009669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 111781009670 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 111781009671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781009672 putative active site [active] 111781009673 heme pocket [chemical binding]; other site 111781009674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781009675 dimer interface [polypeptide binding]; other site 111781009676 phosphorylation site [posttranslational modification] 111781009677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781009678 ATP binding site [chemical binding]; other site 111781009679 Mg2+ binding site [ion binding]; other site 111781009680 G-X-G motif; other site 111781009681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781009682 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781009683 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 111781009684 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009685 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 111781009686 Leucine rich repeat; Region: LRR_8; pfam13855 111781009687 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 111781009688 Leucine rich repeat; Region: LRR_8; pfam13855 111781009689 Substrate binding site [chemical binding]; other site 111781009690 Leucine rich repeat; Region: LRR_8; pfam13855 111781009691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781009692 sequence-specific DNA binding site [nucleotide binding]; other site 111781009693 salt bridge; other site 111781009694 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 111781009695 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 111781009696 putative S-transferase; Provisional; Region: PRK11752 111781009697 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 111781009698 C-terminal domain interface [polypeptide binding]; other site 111781009699 GSH binding site (G-site) [chemical binding]; other site 111781009700 dimer interface [polypeptide binding]; other site 111781009701 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 111781009702 dimer interface [polypeptide binding]; other site 111781009703 N-terminal domain interface [polypeptide binding]; other site 111781009704 active site 111781009705 Caspase domain; Region: Peptidase_C14; pfam00656 111781009706 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781009707 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781009708 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781009709 putative active site [active] 111781009710 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781009711 putative active site [active] 111781009712 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781009713 putative active site [active] 111781009714 excinuclease ABC subunit B; Provisional; Region: PRK05298 111781009715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781009716 ATP binding site [chemical binding]; other site 111781009717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781009718 nucleotide binding region [chemical binding]; other site 111781009719 ATP-binding site [chemical binding]; other site 111781009720 Ultra-violet resistance protein B; Region: UvrB; pfam12344 111781009721 UvrB/uvrC motif; Region: UVR; pfam02151 111781009722 PAS fold; Region: PAS_4; pfam08448 111781009723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781009724 putative active site [active] 111781009725 heme pocket [chemical binding]; other site 111781009726 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781009727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009728 metal binding site [ion binding]; metal-binding site 111781009729 active site 111781009730 I-site; other site 111781009731 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781009732 apocytochrome f; Reviewed; Region: PRK02693 111781009733 cytochrome f; Region: petA; CHL00037 111781009734 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 111781009735 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 111781009736 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 111781009737 cytochrome b subunit interaction site [polypeptide binding]; other site 111781009738 [2Fe-2S] cluster binding site [ion binding]; other site 111781009739 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 111781009740 AMIN domain; Region: AMIN; pfam11741 111781009741 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 111781009742 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 111781009743 phosphopeptide binding site; other site 111781009744 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781009745 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781009746 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781009747 cyclase homology domain; Region: CHD; cd07302 111781009748 nucleotidyl binding site; other site 111781009749 metal binding site [ion binding]; metal-binding site 111781009750 dimer interface [polypeptide binding]; other site 111781009751 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 111781009752 substrate binding site; other site 111781009753 dimer interface; other site 111781009754 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 111781009755 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 111781009756 putative active site [active] 111781009757 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 111781009758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781009759 active site 111781009760 motif I; other site 111781009761 motif II; other site 111781009762 Winged helix-turn helix; Region: HTH_29; pfam13551 111781009763 Homeodomain-like domain; Region: HTH_32; pfam13565 111781009764 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 111781009765 phosphoribulokinase; Provisional; Region: PRK07429 111781009766 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 111781009767 active site 111781009768 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 111781009769 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 111781009770 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 111781009771 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 111781009772 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 111781009773 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 111781009774 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 111781009775 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 111781009776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781009777 Walker A motif; other site 111781009778 ATP binding site [chemical binding]; other site 111781009779 Walker B motif; other site 111781009780 arginine finger; other site 111781009781 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 111781009782 TPR repeat; Region: TPR_11; pfam13414 111781009783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781009784 binding surface 111781009785 TPR motif; other site 111781009786 TPR repeat; Region: TPR_11; pfam13414 111781009787 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 111781009788 RNA/DNA hybrid binding site [nucleotide binding]; other site 111781009789 active site 111781009790 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 111781009791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 111781009792 ATP binding site [chemical binding]; other site 111781009793 putative Mg++ binding site [ion binding]; other site 111781009794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781009795 nucleotide binding region [chemical binding]; other site 111781009796 ATP-binding site [chemical binding]; other site 111781009797 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 111781009798 PhoU domain; Region: PhoU; pfam01895 111781009799 PhoU domain; Region: PhoU; pfam01895 111781009800 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 111781009801 hypothetical protein; Provisional; Region: PRK04194 111781009802 ferrochelatase; Reviewed; Region: hemH; PRK00035 111781009803 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 111781009804 active site 111781009805 C-terminal domain interface [polypeptide binding]; other site 111781009806 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 111781009807 active site 111781009808 N-terminal domain interface [polypeptide binding]; other site 111781009809 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 111781009810 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 111781009811 active site 111781009812 Protein phosphatase 2C; Region: PP2C; pfam00481 111781009813 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 111781009814 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 111781009815 active site 111781009816 homodimer interface [polypeptide binding]; other site 111781009817 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 111781009818 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 111781009819 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781009820 CHASE2 domain; Region: CHASE2; pfam05226 111781009821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009822 metal binding site [ion binding]; metal-binding site 111781009823 active site 111781009824 I-site; other site 111781009825 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781009826 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781009827 CHASE2 domain; Region: CHASE2; pfam05226 111781009828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781009829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781009830 metal binding site [ion binding]; metal-binding site 111781009831 active site 111781009832 I-site; other site 111781009833 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 111781009834 putative metal binding site [ion binding]; other site 111781009835 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 111781009836 metal binding site [ion binding]; metal-binding site 111781009837 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 111781009838 putative metal binding site [ion binding]; other site 111781009839 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 111781009840 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 111781009841 metal binding site [ion binding]; metal-binding site 111781009842 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 111781009843 putative metal binding site [ion binding]; other site 111781009844 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 111781009845 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781009846 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781009847 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781009848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781009849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781009850 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781009851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781009852 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781009853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781009854 binding surface 111781009855 TPR motif; other site 111781009856 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781009857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781009858 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781009859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781009860 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781009861 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781009862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781009863 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781009864 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781009865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781009866 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 111781009867 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009868 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 111781009869 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 111781009870 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 111781009871 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 111781009872 hydrolase, alpha/beta fold family protein; Region: PLN02824 111781009873 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 111781009874 catalytic site [active] 111781009875 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 111781009876 active site 111781009877 catalytic site [active] 111781009878 substrate binding site [chemical binding]; other site 111781009879 yiaA/B two helix domain; Region: YiaAB; cl01759 111781009880 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 111781009881 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 111781009882 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 111781009883 Rhomboid family; Region: Rhomboid; cl11446 111781009884 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 111781009885 Uncharacterized conserved protein [Function unknown]; Region: COG1432 111781009886 LabA_like proteins; Region: LabA; cd10911 111781009887 putative metal binding site [ion binding]; other site 111781009888 2-isopropylmalate synthase; Validated; Region: PRK00915 111781009889 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 111781009890 active site 111781009891 catalytic residues [active] 111781009892 metal binding site [ion binding]; metal-binding site 111781009893 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 111781009894 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 111781009895 nudix motif; other site 111781009896 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 111781009897 homotrimer interaction site [polypeptide binding]; other site 111781009898 putative active site [active] 111781009899 Nuclease-related domain; Region: NERD; pfam08378 111781009900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 111781009901 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781009902 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 111781009903 TrkA-N domain; Region: TrkA_N; pfam02254 111781009904 Cation transport protein; Region: TrkH; cl17365 111781009905 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 111781009906 TrkA-N domain; Region: TrkA_N; pfam02254 111781009907 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 111781009908 active site 111781009909 putative DNA-binding cleft [nucleotide binding]; other site 111781009910 dimer interface [polypeptide binding]; other site 111781009911 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 111781009912 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 111781009913 P loop; other site 111781009914 Nucleotide binding site [chemical binding]; other site 111781009915 DTAP/Switch II; other site 111781009916 Switch I; other site 111781009917 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781009918 DNA polymerase I; Provisional; Region: PRK05755 111781009919 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 111781009920 active site 111781009921 metal binding site 1 [ion binding]; metal-binding site 111781009922 putative 5' ssDNA interaction site; other site 111781009923 metal binding site 3; metal-binding site 111781009924 metal binding site 2 [ion binding]; metal-binding site 111781009925 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 111781009926 putative DNA binding site [nucleotide binding]; other site 111781009927 putative metal binding site [ion binding]; other site 111781009928 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 111781009929 active site 111781009930 catalytic site [active] 111781009931 substrate binding site [chemical binding]; other site 111781009932 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 111781009933 active site 111781009934 DNA binding site [nucleotide binding] 111781009935 catalytic site [active] 111781009936 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 111781009937 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 111781009938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781009939 catalytic residue [active] 111781009940 arginine-tRNA ligase; Region: PLN02286 111781009941 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 111781009942 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 111781009943 active site 111781009944 HIGH motif; other site 111781009945 KMSK motif region; other site 111781009946 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 111781009947 tRNA binding surface [nucleotide binding]; other site 111781009948 anticodon binding site; other site 111781009949 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 111781009950 putative active site [active] 111781009951 catalytic site [active] 111781009952 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 111781009953 salicylate synthase; Region: salicyl_syn; TIGR03494 111781009954 chorismate binding enzyme; Region: Chorismate_bind; cl10555 111781009955 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 111781009956 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 111781009957 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781009958 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781009959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781009960 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 111781009961 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 111781009962 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 111781009963 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781009964 Ion channel; Region: Ion_trans_2; pfam07885 111781009965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781009966 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781009967 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 111781009968 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 111781009969 Catalytic site [active] 111781009970 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 111781009971 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 111781009972 Walker A/P-loop; other site 111781009973 ATP binding site [chemical binding]; other site 111781009974 Q-loop/lid; other site 111781009975 ABC transporter signature motif; other site 111781009976 Walker B; other site 111781009977 D-loop; other site 111781009978 H-loop/switch region; other site 111781009979 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 111781009980 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 111781009981 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 111781009982 putative substrate binding pocket [chemical binding]; other site 111781009983 catalytic triad [active] 111781009984 AB domain interface; other site 111781009985 HEAT repeats; Region: HEAT_2; pfam13646 111781009986 HEAT repeats; Region: HEAT_2; pfam13646 111781009987 HEAT repeats; Region: HEAT_2; pfam13646 111781009988 Lipase (class 2); Region: Lipase_2; pfam01674 111781009989 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781009990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 111781009991 binding surface 111781009992 TPR motif; other site 111781009993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781009994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781009995 Response regulator receiver domain; Region: Response_reg; pfam00072 111781009996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781009997 active site 111781009998 phosphorylation site [posttranslational modification] 111781009999 intermolecular recognition site; other site 111781010000 dimerization interface [polypeptide binding]; other site 111781010001 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781010002 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781010003 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 111781010004 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 111781010005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 111781010006 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 111781010007 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 111781010008 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 111781010009 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781010010 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010011 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781010012 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010013 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010014 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010016 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010017 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 111781010018 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781010019 glycogen synthase; Provisional; Region: glgA; PRK00654 111781010020 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 111781010021 ADP-binding pocket [chemical binding]; other site 111781010022 homodimer interface [polypeptide binding]; other site 111781010023 hypothetical protein; Validated; Region: PRK07411 111781010024 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 111781010025 ATP binding site [chemical binding]; other site 111781010026 substrate interface [chemical binding]; other site 111781010027 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 111781010028 active site residue [active] 111781010029 Transcriptional regulator [Transcription]; Region: LytR; COG1316 111781010030 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 111781010031 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 111781010032 anti sigma factor interaction site; other site 111781010033 regulatory phosphorylation site [posttranslational modification]; other site 111781010034 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781010035 active site 111781010036 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 111781010037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781010038 ATP binding site [chemical binding]; other site 111781010039 Mg2+ binding site [ion binding]; other site 111781010040 G-X-G motif; other site 111781010041 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 111781010042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781010043 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 111781010044 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 111781010045 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 111781010046 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 111781010047 Response regulator receiver domain; Region: Response_reg; pfam00072 111781010048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781010049 active site 111781010050 phosphorylation site [posttranslational modification] 111781010051 intermolecular recognition site; other site 111781010052 dimerization interface [polypeptide binding]; other site 111781010053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781010054 PAS domain; Region: PAS_9; pfam13426 111781010055 putative active site [active] 111781010056 heme pocket [chemical binding]; other site 111781010057 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 111781010058 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 111781010059 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 111781010060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 111781010061 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 111781010062 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 111781010063 homodimer interface [polypeptide binding]; other site 111781010064 active site 111781010065 TDP-binding site; other site 111781010066 acceptor substrate-binding pocket; other site 111781010067 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 111781010068 Bacteriophage protein GP30.3; Region: Phage_30_3; cl17603 111781010069 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 111781010070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010071 Walker A/P-loop; other site 111781010072 ATP binding site [chemical binding]; other site 111781010073 Q-loop/lid; other site 111781010074 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 111781010075 ABC transporter; Region: ABC_tran_2; pfam12848 111781010076 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 111781010077 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 111781010078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010079 S-adenosylmethionine binding site [chemical binding]; other site 111781010080 Protein of unknown function, DUF399; Region: DUF399; pfam04187 111781010081 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 111781010082 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 111781010083 Catalytic site [active] 111781010084 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 111781010085 RimM N-terminal domain; Region: RimM; pfam01782 111781010086 PRC-barrel domain; Region: PRC; pfam05239 111781010087 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 111781010088 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 111781010089 ligand binding site [chemical binding]; other site 111781010090 NAD binding site [chemical binding]; other site 111781010091 dimerization interface [polypeptide binding]; other site 111781010092 catalytic site [active] 111781010093 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 111781010094 putative L-serine binding site [chemical binding]; other site 111781010095 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 111781010096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781010097 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 111781010098 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 111781010099 iron-sulfur cluster [ion binding]; other site 111781010100 [2Fe-2S] cluster binding site [ion binding]; other site 111781010101 Uncharacterized conserved protein [Function unknown]; Region: COG3349 111781010102 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 111781010103 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 111781010104 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 111781010105 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781010106 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781010107 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781010108 ligand binding site [chemical binding]; other site 111781010109 flexible hinge region; other site 111781010110 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 111781010111 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 111781010112 putative active site [active] 111781010113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781010114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010115 Walker A/P-loop; other site 111781010116 ATP binding site [chemical binding]; other site 111781010117 Q-loop/lid; other site 111781010118 ABC transporter signature motif; other site 111781010119 Walker B; other site 111781010120 D-loop; other site 111781010121 H-loop/switch region; other site 111781010122 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 111781010123 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 111781010124 Epoxide hydrolase N terminus; Region: EHN; pfam06441 111781010125 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781010126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010127 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010128 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781010130 non-specific DNA binding site [nucleotide binding]; other site 111781010131 salt bridge; other site 111781010132 sequence-specific DNA binding site [nucleotide binding]; other site 111781010133 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 111781010134 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 111781010135 iron-sulfur cluster [ion binding]; other site 111781010136 [2Fe-2S] cluster binding site [ion binding]; other site 111781010137 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 111781010138 Pheophorbide a oxygenase; Region: PaO; pfam08417 111781010139 RNA pol II promoter Fmp27 protein domain; Region: Fmp27_GFWDK; pfam10347 111781010140 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 111781010141 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 111781010142 TrkA-N domain; Region: TrkA_N; pfam02254 111781010143 TrkA-C domain; Region: TrkA_C; pfam02080 111781010144 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 111781010145 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 111781010146 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 111781010147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781010148 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 111781010149 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 111781010150 Walker A/P-loop; other site 111781010151 ATP binding site [chemical binding]; other site 111781010152 Q-loop/lid; other site 111781010153 ABC transporter signature motif; other site 111781010154 Walker B; other site 111781010155 D-loop; other site 111781010156 H-loop/switch region; other site 111781010157 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 111781010158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 111781010159 Walker A/P-loop; other site 111781010160 ATP binding site [chemical binding]; other site 111781010161 Q-loop/lid; other site 111781010162 ABC transporter signature motif; other site 111781010163 Walker B; other site 111781010164 D-loop; other site 111781010165 H-loop/switch region; other site 111781010166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 111781010167 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 111781010168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010169 Walker A/P-loop; other site 111781010170 ATP binding site [chemical binding]; other site 111781010171 Q-loop/lid; other site 111781010172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 111781010173 ABC transporter signature motif; other site 111781010174 Walker B; other site 111781010175 D-loop; other site 111781010176 ABC transporter; Region: ABC_tran_2; pfam12848 111781010177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 111781010178 Cache domain; Region: Cache_1; pfam02743 111781010179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 111781010180 PAS domain S-box; Region: sensory_box; TIGR00229 111781010181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781010182 putative active site [active] 111781010183 heme pocket [chemical binding]; other site 111781010184 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781010185 cyclase homology domain; Region: CHD; cd07302 111781010186 nucleotidyl binding site; other site 111781010187 metal binding site [ion binding]; metal-binding site 111781010188 dimer interface [polypeptide binding]; other site 111781010189 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781010190 Response regulator receiver domain; Region: Response_reg; pfam00072 111781010191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781010192 active site 111781010193 phosphorylation site [posttranslational modification] 111781010194 intermolecular recognition site; other site 111781010195 dimerization interface [polypeptide binding]; other site 111781010196 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 111781010197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010198 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010199 Integrase core domain; Region: rve; pfam00665 111781010200 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010201 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010202 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010203 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010205 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010206 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010208 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781010209 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781010210 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 111781010211 Predicted ATPase [General function prediction only]; Region: COG4637 111781010212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010213 Walker A/P-loop; other site 111781010214 ATP binding site [chemical binding]; other site 111781010215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010216 ABC transporter signature motif; other site 111781010217 Walker B; other site 111781010218 D-loop; other site 111781010219 H-loop/switch region; other site 111781010220 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 111781010221 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 111781010222 PLD-like domain; Region: PLDc_2; pfam13091 111781010223 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 111781010224 putative homodimer interface [polypeptide binding]; other site 111781010225 putative active site [active] 111781010226 catalytic site [active] 111781010227 DEAD-like helicases superfamily; Region: DEXDc; smart00487 111781010228 DEAD/DEAH box helicase; Region: DEAD; pfam00270 111781010229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 111781010230 nucleotide binding region [chemical binding]; other site 111781010231 ATP-binding site [chemical binding]; other site 111781010232 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 111781010233 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 111781010234 GCN5-like protein 1 (GCN5L1); Region: GCN5L1; pfam06320 111781010235 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 111781010236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781010237 non-specific DNA binding site [nucleotide binding]; other site 111781010238 salt bridge; other site 111781010239 sequence-specific DNA binding site [nucleotide binding]; other site 111781010240 Domain of unknown function (DUF955); Region: DUF955; cl01076 111781010241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781010242 non-specific DNA binding site [nucleotide binding]; other site 111781010243 salt bridge; other site 111781010244 sequence-specific DNA binding site [nucleotide binding]; other site 111781010245 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 111781010246 MT-A70; Region: MT-A70; cl01947 111781010247 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 111781010248 Ligand Binding Site [chemical binding]; other site 111781010249 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 111781010250 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 111781010251 active site 111781010252 metal binding site [ion binding]; metal-binding site 111781010253 interdomain interaction site; other site 111781010254 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 111781010255 Virulence-associated protein E; Region: VirE; pfam05272 111781010256 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 111781010257 active site 111781010258 catalytic residues [active] 111781010259 DNA binding site [nucleotide binding] 111781010260 Int/Topo IB signature motif; other site 111781010261 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 111781010262 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 111781010263 active site 111781010264 metal binding site [ion binding]; metal-binding site 111781010265 interdomain interaction site; other site 111781010266 Phage associated DNA primase [General function prediction only]; Region: COG3378 111781010267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010268 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010269 MT-A70; Region: MT-A70; cl01947 111781010270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010271 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010272 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 111781010273 MT-A70; Region: MT-A70; cl01947 111781010274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781010275 non-specific DNA binding site [nucleotide binding]; other site 111781010276 salt bridge; other site 111781010277 sequence-specific DNA binding site [nucleotide binding]; other site 111781010278 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 111781010279 RNB domain; Region: RNB; pfam00773 111781010280 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010282 NB-ARC domain; Region: NB-ARC; pfam00931 111781010283 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010286 binding surface 111781010287 TPR motif; other site 111781010288 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010290 TPR motif; other site 111781010291 binding surface 111781010292 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010295 binding surface 111781010296 TPR motif; other site 111781010297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010298 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 111781010299 Dof domain, zinc finger; Region: zf-Dof; pfam02701 111781010300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010301 biofilm formation regulator HmsP; Provisional; Region: PRK11829 111781010302 NACHT domain; Region: NACHT; pfam05729 111781010303 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781010304 WD domain, G-beta repeat; Region: WD40; pfam00400 111781010305 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781010306 structural tetrad; other site 111781010307 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781010308 structural tetrad; other site 111781010309 CARDB; Region: CARDB; pfam07705 111781010310 CARDB; Region: CARDB; pfam07705 111781010311 CARDB; Region: CARDB; pfam07705 111781010312 CARDB; Region: CARDB; pfam07705 111781010313 CARDB; Region: CARDB; pfam07705 111781010314 CARDB; Region: CARDB; pfam07705 111781010315 CARDB; Region: CARDB; pfam07705 111781010316 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010317 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 111781010318 RHS Repeat; Region: RHS_repeat; pfam05593 111781010319 RHS Repeat; Region: RHS_repeat; pfam05593 111781010320 RHS Repeat; Region: RHS_repeat; pfam05593 111781010321 RHS Repeat; Region: RHS_repeat; pfam05593 111781010322 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 111781010323 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781010324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010325 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010326 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010327 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010328 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010329 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010330 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010331 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010332 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 111781010333 RHS Repeat; Region: RHS_repeat; pfam05593 111781010334 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 111781010335 RHS Repeat; Region: RHS_repeat; pfam05593 111781010336 RHS Repeat; Region: RHS_repeat; pfam05593 111781010337 RHS Repeat; Region: RHS_repeat; pfam05593 111781010338 RHS Repeat; Region: RHS_repeat; pfam05593 111781010339 RHS Repeat; Region: RHS_repeat; pfam05593 111781010340 RHS Repeat; Region: RHS_repeat; pfam05593 111781010341 RHS Repeat; Region: RHS_repeat; pfam05593 111781010342 RHS Repeat; Region: RHS_repeat; pfam05593 111781010343 RHS Repeat; Region: RHS_repeat; pfam05593 111781010344 RHS Repeat; Region: RHS_repeat; pfam05593 111781010345 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 111781010346 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 111781010347 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010348 DDE superfamily endonuclease; Region: DDE_4; pfam13359 111781010349 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781010350 putative active site [active] 111781010351 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 111781010352 active site 111781010353 catalytic residues [active] 111781010354 DNA binding site [nucleotide binding] 111781010355 Int/Topo IB signature motif; other site 111781010356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010357 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010358 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010361 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010362 Integrase core domain; Region: rve; pfam00665 111781010363 XisH protein; Region: XisH; pfam08814 111781010364 XisI protein; Region: XisI; pfam08869 111781010365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010366 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010367 Integrase core domain; Region: rve; pfam00665 111781010368 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 111781010369 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 111781010370 active site 111781010371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010372 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781010373 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 111781010374 active site 111781010375 catalytic residues [active] 111781010376 DNA binding site [nucleotide binding] 111781010377 Int/Topo IB signature motif; other site 111781010378 Uncharacterized conserved protein [Function unknown]; Region: COG2442 111781010379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 111781010380 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781010381 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781010382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010383 Homeodomain-like domain; Region: HTH_32; pfam13565 111781010384 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781010387 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781010388 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781010389 CHASE2 domain; Region: CHASE2; pfam05226 111781010390 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781010391 cyclase homology domain; Region: CHD; cd07302 111781010392 nucleotidyl binding site; other site 111781010393 metal binding site [ion binding]; metal-binding site 111781010394 dimer interface [polypeptide binding]; other site 111781010395 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781010396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010397 Homeodomain-like domain; Region: HTH_32; pfam13565 111781010398 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010400 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010401 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010402 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781010403 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781010404 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 111781010405 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 111781010406 putative active site [active] 111781010407 putative NTP binding site [chemical binding]; other site 111781010408 putative nucleic acid binding site [nucleotide binding]; other site 111781010409 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781010410 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781010411 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 111781010412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781010413 AAA domain; Region: AAA_22; pfam13401 111781010414 Walker A motif; other site 111781010415 ATP binding site [chemical binding]; other site 111781010416 Walker B motif; other site 111781010417 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781010418 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781010419 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781010420 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781010421 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781010422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010423 binding surface 111781010424 TPR motif; other site 111781010425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781010426 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781010427 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781010428 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781010429 FG-GAP repeat; Region: FG-GAP_2; pfam14312 111781010430 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781010431 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781010432 CHAT domain; Region: CHAT; cl17868 111781010433 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781010434 cyclase homology domain; Region: CHD; cd07302 111781010435 nucleotidyl binding site; other site 111781010436 metal binding site [ion binding]; metal-binding site 111781010437 dimer interface [polypeptide binding]; other site 111781010438 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781010439 CHASE2 domain; Region: CHASE2; pfam05226 111781010440 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 111781010441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010442 Homeodomain-like domain; Region: HTH_32; pfam13565 111781010443 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010445 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781010446 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781010447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010448 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010449 Integrase core domain; Region: rve; pfam00665 111781010450 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 111781010451 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781010452 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781010453 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781010454 G1 box; other site 111781010455 GTP/Mg2+ binding site [chemical binding]; other site 111781010456 G2 box; other site 111781010457 Switch I region; other site 111781010458 G3 box; other site 111781010459 Switch II region; other site 111781010460 G4 box; other site 111781010461 G5 box; other site 111781010462 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781010463 G1 box; other site 111781010464 GTP/Mg2+ binding site [chemical binding]; other site 111781010465 G2 box; other site 111781010466 Switch I region; other site 111781010467 G3 box; other site 111781010468 Switch II region; other site 111781010469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010470 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010471 Integrase core domain; Region: rve; pfam00665 111781010472 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 111781010473 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 111781010474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010475 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010476 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010478 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010479 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 111781010480 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 111781010481 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 111781010482 Ligand Binding Site [chemical binding]; other site 111781010483 DKNYY family; Region: DKNYY; pfam13644 111781010484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010485 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010486 Integrase core domain; Region: rve; pfam00665 111781010487 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 111781010488 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 111781010489 HIGH motif; other site 111781010490 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 111781010491 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 111781010492 active site 111781010493 KMSKS motif; other site 111781010494 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 111781010495 tRNA binding surface [nucleotide binding]; other site 111781010496 Response regulator receiver domain; Region: Response_reg; pfam00072 111781010497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781010498 active site 111781010499 phosphorylation site [posttranslational modification] 111781010500 intermolecular recognition site; other site 111781010501 dimerization interface [polypeptide binding]; other site 111781010502 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 111781010503 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 111781010504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 111781010505 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781010506 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781010507 ligand binding site [chemical binding]; other site 111781010508 flexible hinge region; other site 111781010509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781010510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781010511 ATP binding site [chemical binding]; other site 111781010512 Mg2+ binding site [ion binding]; other site 111781010513 G-X-G motif; other site 111781010514 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149 111781010515 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 111781010516 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 111781010517 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 111781010518 active site 111781010519 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 111781010520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 111781010521 substrate binding pocket [chemical binding]; other site 111781010522 membrane-bound complex binding site; other site 111781010523 hinge residues; other site 111781010524 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 111781010525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781010526 dimerization interface [polypeptide binding]; other site 111781010527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781010528 dimer interface [polypeptide binding]; other site 111781010529 phosphorylation site [posttranslational modification] 111781010530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781010531 ATP binding site [chemical binding]; other site 111781010532 Mg2+ binding site [ion binding]; other site 111781010533 G-X-G motif; other site 111781010534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010535 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 111781010536 Walker A/P-loop; other site 111781010537 ATP binding site [chemical binding]; other site 111781010538 Q-loop/lid; other site 111781010539 ABC transporter signature motif; other site 111781010540 Walker B; other site 111781010541 D-loop; other site 111781010542 H-loop/switch region; other site 111781010543 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 111781010544 trimer interface [polypeptide binding]; other site 111781010545 putative substrate binding pocket [chemical binding]; other site 111781010546 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 111781010547 active site 1 [active] 111781010548 dimer interface [polypeptide binding]; other site 111781010549 hexamer interface [polypeptide binding]; other site 111781010550 active site 2 [active] 111781010551 Protein of unknown function (DUF497); Region: DUF497; cl01108 111781010552 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 111781010553 recombination protein F; Reviewed; Region: recF; PRK00064 111781010554 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 111781010555 Walker A/P-loop; other site 111781010556 ATP binding site [chemical binding]; other site 111781010557 Q-loop/lid; other site 111781010558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010559 ABC transporter signature motif; other site 111781010560 Walker B; other site 111781010561 D-loop; other site 111781010562 H-loop/switch region; other site 111781010563 Protein of unknown function (DUF904); Region: DUF904; cl11531 111781010564 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 111781010565 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 111781010566 dimer interface [polypeptide binding]; other site 111781010567 motif 1; other site 111781010568 active site 111781010569 motif 2; other site 111781010570 motif 3; other site 111781010571 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 111781010572 anticodon binding site; other site 111781010573 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 111781010574 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 111781010575 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781010576 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 111781010577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 111781010578 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 111781010579 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 111781010580 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 111781010581 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 111781010582 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 111781010583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010584 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781010585 Integrase core domain; Region: rve; pfam00665 111781010586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010587 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781010588 YcxB-like protein; Region: YcxB; pfam14317 111781010589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010590 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010591 Septum formation; Region: Septum_form; pfam13845 111781010592 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781010593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010594 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010595 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010596 Staphylococcal nuclease homologues; Region: SNc; smart00318 111781010597 Catalytic site; other site 111781010598 Staphylococcal nuclease homologue; Region: SNase; pfam00565 111781010599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781010600 non-specific DNA binding site [nucleotide binding]; other site 111781010601 salt bridge; other site 111781010602 sequence-specific DNA binding site [nucleotide binding]; other site 111781010603 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 111781010604 Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341 111781010605 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 111781010606 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 111781010607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781010608 dimer interface [polypeptide binding]; other site 111781010609 conserved gate region; other site 111781010610 putative PBP binding loops; other site 111781010611 ABC-ATPase subunit interface; other site 111781010612 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 111781010613 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781010614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010615 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010616 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010617 glycine dehydrogenase; Provisional; Region: PRK05367 111781010618 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 111781010619 tetramer interface [polypeptide binding]; other site 111781010620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781010621 catalytic residue [active] 111781010622 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 111781010623 tetramer interface [polypeptide binding]; other site 111781010624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781010625 catalytic residue [active] 111781010626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010627 Homeodomain-like domain; Region: HTH_32; pfam13565 111781010628 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010630 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 111781010631 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010632 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010634 S-adenosylmethionine binding site [chemical binding]; other site 111781010635 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 111781010636 Short C-terminal domain; Region: SHOCT; pfam09851 111781010637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781010638 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 111781010639 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 111781010640 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010642 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010643 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010644 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781010645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010646 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010647 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010648 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 111781010649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 111781010650 Walker A/P-loop; other site 111781010651 ATP binding site [chemical binding]; other site 111781010652 Q-loop/lid; other site 111781010653 ABC transporter signature motif; other site 111781010654 Walker B; other site 111781010655 D-loop; other site 111781010656 H-loop/switch region; other site 111781010657 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 111781010658 RibD C-terminal domain; Region: RibD_C; cl17279 111781010659 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 111781010660 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 111781010661 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 111781010662 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 111781010663 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 111781010664 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 111781010665 AMIN domain; Region: AMIN; pfam11741 111781010666 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 111781010667 Secretin and TonB N terminus short domain; Region: STN; pfam07660 111781010668 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 111781010669 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 111781010670 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 111781010671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781010672 motif II; other site 111781010673 16S rRNA methyltransferase B; Provisional; Region: PRK14901 111781010674 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 111781010675 putative RNA binding site [nucleotide binding]; other site 111781010676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010677 S-adenosylmethionine binding site [chemical binding]; other site 111781010678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 111781010679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781010680 Coenzyme A binding pocket [chemical binding]; other site 111781010681 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 111781010682 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 111781010683 active site 111781010684 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 111781010685 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781010686 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 111781010687 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 111781010688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 111781010689 Uncharacterized conserved protein [Function unknown]; Region: COG5439 111781010690 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 111781010691 cyclase homology domain; Region: CHD; cd07302 111781010692 nucleotidyl binding site; other site 111781010693 metal binding site [ion binding]; metal-binding site 111781010694 dimer interface [polypeptide binding]; other site 111781010695 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 111781010696 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 111781010697 Protein of unknown function DUF58; Region: DUF58; pfam01882 111781010698 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 111781010699 GIY-YIG motif/motif A; other site 111781010700 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 111781010701 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 111781010702 ABC-ATPase subunit interface; other site 111781010703 dimer interface [polypeptide binding]; other site 111781010704 putative PBP binding regions; other site 111781010705 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 111781010706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 111781010707 ABC-ATPase subunit interface; other site 111781010708 dimer interface [polypeptide binding]; other site 111781010709 putative PBP binding regions; other site 111781010710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010711 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010712 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 111781010715 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 111781010716 putative NAD(P) binding site [chemical binding]; other site 111781010717 putative active site [active] 111781010718 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 111781010719 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 111781010720 catalytic residue [active] 111781010721 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 111781010722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781010723 Methyltransferase domain; Region: Methyltransf_23; pfam13489 111781010724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010725 S-adenosylmethionine binding site [chemical binding]; other site 111781010726 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 111781010727 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 111781010728 inhibitor-cofactor binding pocket; inhibition site 111781010729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781010730 catalytic residue [active] 111781010731 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781010732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010733 S-adenosylmethionine binding site [chemical binding]; other site 111781010734 mechanosensitive channel MscS; Provisional; Region: PRK10334 111781010735 Mechanosensitive ion channel; Region: MS_channel; pfam00924 111781010736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010737 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010738 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010740 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781010741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781010742 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781010743 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781010744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 111781010745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781010746 dimer interface [polypeptide binding]; other site 111781010747 conserved gate region; other site 111781010748 putative PBP binding loops; other site 111781010749 ABC-ATPase subunit interface; other site 111781010750 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 111781010751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 111781010752 active site 111781010753 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 111781010754 homodecamer interface [polypeptide binding]; other site 111781010755 GTP cyclohydrolase I; Provisional; Region: PLN03044 111781010756 active site 111781010757 putative catalytic site residues [active] 111781010758 zinc binding site [ion binding]; other site 111781010759 GTP-CH-I/GFRP interaction surface; other site 111781010760 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 111781010761 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 111781010762 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 111781010763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 111781010764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 111781010765 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 111781010766 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 111781010767 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 111781010768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 111781010769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781010770 active site 111781010771 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 111781010772 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 111781010773 FMN binding site [chemical binding]; other site 111781010774 active site 111781010775 substrate binding site [chemical binding]; other site 111781010776 catalytic residue [active] 111781010777 GAF domain; Region: GAF; cl17456 111781010778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 111781010779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 111781010780 DNA binding residues [nucleotide binding] 111781010781 dimerization interface [polypeptide binding]; other site 111781010782 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 111781010783 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 111781010784 active site residue [active] 111781010785 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 111781010786 active site residue [active] 111781010787 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 111781010788 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 111781010789 Multicopper oxidase; Region: Cu-oxidase; pfam00394 111781010790 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 111781010791 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 111781010792 Predicted metal-binding protein [General function prediction only]; Region: COG3019 111781010793 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 111781010794 catalytic triad [active] 111781010795 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 111781010796 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 111781010797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 111781010798 catalytic residue [active] 111781010799 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 111781010800 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 111781010801 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 111781010802 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 111781010803 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 111781010804 Methyltransferase domain; Region: Methyltransf_31; pfam13847 111781010805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010806 S-adenosylmethionine binding site [chemical binding]; other site 111781010807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781010808 S-adenosylmethionine binding site [chemical binding]; other site 111781010809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781010810 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 111781010811 Coenzyme A binding pocket [chemical binding]; other site 111781010812 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 111781010813 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 111781010814 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 111781010815 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 111781010816 protein binding site [polypeptide binding]; other site 111781010817 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 111781010818 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 111781010819 Sulfate transporter family; Region: Sulfate_transp; pfam00916 111781010820 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 111781010821 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 111781010822 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 111781010823 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 111781010824 Cupin domain; Region: Cupin_2; cl17218 111781010825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 111781010826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 111781010827 motif II; other site 111781010828 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 111781010829 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 111781010830 Leucine rich repeat; Region: LRR_8; pfam13855 111781010831 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 111781010832 Substrate binding site [chemical binding]; other site 111781010833 Leucine rich repeat; Region: LRR_8; pfam13855 111781010834 Leucine rich repeat; Region: LRR_8; pfam13855 111781010835 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 111781010836 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781010837 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 111781010838 G1 box; other site 111781010839 GTP/Mg2+ binding site [chemical binding]; other site 111781010840 G2 box; other site 111781010841 Switch I region; other site 111781010842 G3 box; other site 111781010843 Switch II region; other site 111781010844 G4 box; other site 111781010845 G5 box; other site 111781010846 SnoaL-like domain; Region: SnoaL_2; pfam12680 111781010847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 111781010848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781010849 Homeodomain-like domain; Region: HTH_32; pfam13565 111781010850 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781010851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781010852 prolyl-tRNA synthetase; Provisional; Region: PRK09194 111781010853 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 111781010854 dimer interface [polypeptide binding]; other site 111781010855 motif 1; other site 111781010856 active site 111781010857 motif 2; other site 111781010858 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 111781010859 putative deacylase active site [active] 111781010860 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 111781010861 active site 111781010862 motif 3; other site 111781010863 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 111781010864 anticodon binding site; other site 111781010865 Uncharacterized conserved protein [Function unknown]; Region: COG1479 111781010866 Protein of unknown function DUF262; Region: DUF262; pfam03235 111781010867 Uncharacterized conserved protein [Function unknown]; Region: COG3472 111781010868 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 111781010869 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 111781010870 Protein kinase domain; Region: Pkinase; pfam00069 111781010871 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781010872 active site 111781010873 ATP binding site [chemical binding]; other site 111781010874 substrate binding site [chemical binding]; other site 111781010875 activation loop (A-loop); other site 111781010876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010877 binding surface 111781010878 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781010879 TPR motif; other site 111781010880 Tetratricopeptide repeat; Region: TPR_16; pfam13432 111781010881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010882 binding surface 111781010883 TPR motif; other site 111781010884 TPR repeat; Region: TPR_11; pfam13414 111781010885 TPR repeat; Region: TPR_11; pfam13414 111781010886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010887 binding surface 111781010888 TPR motif; other site 111781010889 TPR repeat; Region: TPR_11; pfam13414 111781010890 TPR repeat; Region: TPR_11; pfam13414 111781010891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781010892 binding surface 111781010893 TPR motif; other site 111781010894 TPR repeat; Region: TPR_11; pfam13414 111781010895 SET domain; Region: SET; pfam00856 111781010896 DKNYY family; Region: DKNYY; pfam13644 111781010897 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781010898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781010899 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 111781010900 Recombination protein O N terminal; Region: RecO_N; pfam11967 111781010901 Recombination protein O C terminal; Region: RecO_C; pfam02565 111781010902 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 111781010903 intersubunit interface [polypeptide binding]; other site 111781010904 active site 111781010905 catalytic residue [active] 111781010906 PetN; Region: PetN; cl15376 111781010907 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 111781010908 translation initiation factor IF-2; Region: IF-2; TIGR00487 111781010909 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 111781010910 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 111781010911 G1 box; other site 111781010912 putative GEF interaction site [polypeptide binding]; other site 111781010913 GTP/Mg2+ binding site [chemical binding]; other site 111781010914 Switch I region; other site 111781010915 G2 box; other site 111781010916 G3 box; other site 111781010917 Switch II region; other site 111781010918 G4 box; other site 111781010919 G5 box; other site 111781010920 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 111781010921 Translation-initiation factor 2; Region: IF-2; pfam11987 111781010922 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 111781010923 Protein of unknown function (DUF448); Region: DUF448; pfam04296 111781010924 putative RNA binding cleft [nucleotide binding]; other site 111781010925 transcription termination factor NusA; Region: NusA; TIGR01953 111781010926 NusA N-terminal domain; Region: NusA_N; pfam08529 111781010927 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 111781010928 RNA binding site [nucleotide binding]; other site 111781010929 homodimer interface [polypeptide binding]; other site 111781010930 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 111781010931 G-X-X-G motif; other site 111781010932 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 111781010933 G-X-X-G motif; other site 111781010934 ribosome maturation protein RimP; Reviewed; Region: PRK00092 111781010935 Sm and related proteins; Region: Sm_like; cl00259 111781010936 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 111781010937 putative oligomer interface [polypeptide binding]; other site 111781010938 putative RNA binding site [nucleotide binding]; other site 111781010939 hypothetical protein; Provisional; Region: PRK02724 111781010940 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 111781010941 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 111781010942 gamma subunit interface [polypeptide binding]; other site 111781010943 epsilon subunit interface [polypeptide binding]; other site 111781010944 LBP interface [polypeptide binding]; other site 111781010945 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 111781010946 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 111781010947 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 111781010948 alpha subunit interaction interface [polypeptide binding]; other site 111781010949 Walker A motif; other site 111781010950 ATP binding site [chemical binding]; other site 111781010951 Walker B motif; other site 111781010952 inhibitor binding site; inhibition site 111781010953 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 111781010954 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 111781010955 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 111781010956 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 111781010957 dimer interface [polypeptide binding]; other site 111781010958 RNA polymerase sigma factor; Provisional; Region: PRK12518 111781010959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781010960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781010961 DNA binding residues [nucleotide binding] 111781010962 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 111781010963 Transglycosylase; Region: Transgly; pfam00912 111781010964 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 111781010965 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 111781010966 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 111781010967 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 111781010968 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 111781010969 TrkA-N domain; Region: TrkA_N; pfam02254 111781010970 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 111781010971 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 111781010972 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 111781010973 Nucleoside recognition; Region: Gate; pfam07670 111781010974 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 111781010975 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 111781010976 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 111781010977 active site 111781010978 dimer interface [polypeptide binding]; other site 111781010979 metal binding site [ion binding]; metal-binding site 111781010980 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 111781010981 active site 111781010982 Leucine rich repeat; Region: LRR_8; pfam13855 111781010983 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 111781010984 Leucine-rich repeats; other site 111781010985 Substrate binding site [chemical binding]; other site 111781010986 Leucine rich repeat; Region: LRR_8; pfam13855 111781010987 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 111781010988 AAA domain; Region: AAA_22; pfam13401 111781010989 G1 box; other site 111781010990 GTP/Mg2+ binding site [chemical binding]; other site 111781010991 G2 box; other site 111781010992 Switch I region; other site 111781010993 G3 box; other site 111781010994 Switch II region; other site 111781010995 G4 box; other site 111781010996 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 111781010997 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 111781010998 Walker A/P-loop; other site 111781010999 ATP binding site [chemical binding]; other site 111781011000 Q-loop/lid; other site 111781011001 ABC transporter signature motif; other site 111781011002 Walker B; other site 111781011003 D-loop; other site 111781011004 H-loop/switch region; other site 111781011005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 111781011006 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 111781011007 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 111781011008 Walker A/P-loop; other site 111781011009 ATP binding site [chemical binding]; other site 111781011010 Q-loop/lid; other site 111781011011 ABC transporter signature motif; other site 111781011012 Walker B; other site 111781011013 D-loop; other site 111781011014 H-loop/switch region; other site 111781011015 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 111781011016 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 111781011017 active site 111781011018 catalytic residues [active] 111781011019 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 111781011020 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 111781011021 active site 111781011022 dimer interface [polypeptide binding]; other site 111781011023 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 111781011024 dimer interface [polypeptide binding]; other site 111781011025 active site 111781011026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011027 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011028 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011030 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781011031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781011032 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 111781011033 diiron binding motif [ion binding]; other site 111781011034 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011036 active site 111781011037 phosphorylation site [posttranslational modification] 111781011038 intermolecular recognition site; other site 111781011039 dimerization interface [polypeptide binding]; other site 111781011040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781011041 PAS fold; Region: PAS_3; pfam08447 111781011042 putative active site [active] 111781011043 heme pocket [chemical binding]; other site 111781011044 PAS domain S-box; Region: sensory_box; TIGR00229 111781011045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781011046 putative active site [active] 111781011047 heme pocket [chemical binding]; other site 111781011048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781011049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781011050 metal binding site [ion binding]; metal-binding site 111781011051 active site 111781011052 I-site; other site 111781011053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781011054 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781011055 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781011056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011057 Homeodomain-like domain; Region: HTH_32; pfam13565 111781011058 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011061 ATP binding site [chemical binding]; other site 111781011062 Mg2+ binding site [ion binding]; other site 111781011063 G-X-G motif; other site 111781011064 Uncharacterized conserved protein [Function unknown]; Region: COG3287 111781011065 FIST N domain; Region: FIST; pfam08495 111781011066 FIST C domain; Region: FIST_C; pfam10442 111781011067 magnesium chelatase subunit H; Provisional; Region: PLN03241 111781011068 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 111781011069 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 111781011070 Isochorismatase family; Region: Isochorismatase; pfam00857 111781011071 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 111781011072 catalytic triad [active] 111781011073 conserved cis-peptide bond; other site 111781011074 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 111781011075 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 111781011076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781011077 active site 111781011078 metal binding site [ion binding]; metal-binding site 111781011079 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 111781011080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781011081 S-adenosylmethionine binding site [chemical binding]; other site 111781011082 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011084 active site 111781011085 phosphorylation site [posttranslational modification] 111781011086 intermolecular recognition site; other site 111781011087 dimerization interface [polypeptide binding]; other site 111781011088 GAF domain; Region: GAF_2; pfam13185 111781011089 GAF domain; Region: GAF; pfam01590 111781011090 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 111781011091 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 111781011092 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 111781011093 FtsX-like permease family; Region: FtsX; pfam02687 111781011094 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 111781011095 FtsX-like permease family; Region: FtsX; pfam02687 111781011096 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 111781011097 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 111781011098 Walker A/P-loop; other site 111781011099 ATP binding site [chemical binding]; other site 111781011100 Q-loop/lid; other site 111781011101 ABC transporter signature motif; other site 111781011102 Walker B; other site 111781011103 D-loop; other site 111781011104 H-loop/switch region; other site 111781011105 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 111781011106 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781011107 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 111781011108 putative NAD(P) binding site [chemical binding]; other site 111781011109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781011110 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781011111 Integrase core domain; Region: rve; pfam00665 111781011112 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781011113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781011114 DDE domain; Region: DDE_Tnp_IS240; pfam13610 111781011115 Integrase core domain; Region: rve; pfam00665 111781011116 Surface antigen; Region: Bac_surface_Ag; pfam01103 111781011117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011119 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781011121 TPR motif; other site 111781011122 binding surface 111781011123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011126 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011127 CHAT domain; Region: CHAT; cl17868 111781011128 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 111781011129 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 111781011130 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 111781011131 HEAT repeats; Region: HEAT_2; pfam13646 111781011132 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 111781011133 protein binding surface [polypeptide binding]; other site 111781011134 HEAT repeats; Region: HEAT_2; pfam13646 111781011135 HEAT repeats; Region: HEAT_2; pfam13646 111781011136 HEAT repeats; Region: HEAT_2; pfam13646 111781011137 HEAT repeats; Region: HEAT_2; pfam13646 111781011138 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 111781011139 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 111781011140 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 111781011141 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 111781011142 catalytic triad [active] 111781011143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011144 Homeodomain-like domain; Region: HTH_32; pfam13565 111781011145 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011147 SapC; Region: SapC; pfam07277 111781011148 Autotransporter beta-domain; Region: Autotransporter; smart00869 111781011149 Uncharacterized conserved protein [Function unknown]; Region: COG2442 111781011150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 111781011151 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 111781011152 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 111781011153 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 111781011154 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 111781011155 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 111781011156 RHS Repeat; Region: RHS_repeat; pfam05593 111781011157 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 111781011158 RHS Repeat; Region: RHS_repeat; pfam05593 111781011159 RHS Repeat; Region: RHS_repeat; pfam05593 111781011160 RHS Repeat; Region: RHS_repeat; pfam05593 111781011161 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 111781011162 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 111781011163 RHS Repeat; Region: RHS_repeat; pfam05593 111781011164 RHS Repeat; Region: RHS_repeat; pfam05593 111781011165 RHS Repeat; Region: RHS_repeat; pfam05593 111781011166 RHS Repeat; Region: RHS_repeat; pfam05593 111781011167 RHS Repeat; Region: RHS_repeat; pfam05593 111781011168 RHS Repeat; Region: RHS_repeat; pfam05593 111781011169 RHS Repeat; Region: RHS_repeat; pfam05593 111781011170 RHS Repeat; Region: RHS_repeat; pfam05593 111781011171 RHS Repeat; Region: RHS_repeat; cl11982 111781011172 RHS Repeat; Region: RHS_repeat; cl11982 111781011173 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 111781011174 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 111781011175 Protein phosphatase 2C; Region: PP2C_2; pfam13672 111781011176 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 111781011177 active site 111781011178 ATP binding site [chemical binding]; other site 111781011179 substrate binding site [chemical binding]; other site 111781011180 activation loop (A-loop); other site 111781011181 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781011182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781011183 active site 111781011184 ATP binding site [chemical binding]; other site 111781011185 substrate binding site [chemical binding]; other site 111781011186 activation loop (A-loop); other site 111781011187 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 111781011188 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 111781011189 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 111781011190 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 111781011191 dimer interface [polypeptide binding]; other site 111781011192 motif 1; other site 111781011193 active site 111781011194 motif 2; other site 111781011195 motif 3; other site 111781011196 TM2 domain; Region: TM2; pfam05154 111781011197 Tic20-like protein; Region: Tic20; pfam09685 111781011198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 111781011199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011200 active site 111781011201 phosphorylation site [posttranslational modification] 111781011202 intermolecular recognition site; other site 111781011203 dimerization interface [polypeptide binding]; other site 111781011204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781011205 DNA binding site [nucleotide binding] 111781011206 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 111781011207 active site 111781011208 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011209 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 111781011210 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011211 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 111781011212 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011213 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 111781011214 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011215 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011216 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 111781011217 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011218 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 111781011219 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 111781011220 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 111781011221 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 111781011222 metal binding site 2 [ion binding]; metal-binding site 111781011223 putative DNA binding helix; other site 111781011224 metal binding site 1 [ion binding]; metal-binding site 111781011225 dimer interface [polypeptide binding]; other site 111781011226 structural Zn2+ binding site [ion binding]; other site 111781011227 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 111781011228 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 111781011229 Walker A/P-loop; other site 111781011230 ATP binding site [chemical binding]; other site 111781011231 Q-loop/lid; other site 111781011232 ABC transporter signature motif; other site 111781011233 Walker B; other site 111781011234 D-loop; other site 111781011235 H-loop/switch region; other site 111781011236 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 111781011237 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 111781011238 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 111781011239 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 111781011240 catalytic triad [active] 111781011241 dimer interface [polypeptide binding]; other site 111781011242 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 111781011243 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781011244 cyclase homology domain; Region: CHD; cd07302 111781011245 nucleotidyl binding site; other site 111781011246 metal binding site [ion binding]; metal-binding site 111781011247 dimer interface [polypeptide binding]; other site 111781011248 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 111781011249 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781011250 cyclase homology domain; Region: CHD; cd07302 111781011251 nucleotidyl binding site; other site 111781011252 metal binding site [ion binding]; metal-binding site 111781011253 dimer interface [polypeptide binding]; other site 111781011254 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 111781011255 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 111781011256 P loop; other site 111781011257 Nucleotide binding site [chemical binding]; other site 111781011258 DTAP/Switch II; other site 111781011259 Switch I; other site 111781011260 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 111781011261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 111781011262 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 111781011263 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 111781011264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 111781011265 Catalytic domain of Protein Kinases; Region: PKc; cd00180 111781011266 active site 111781011267 ATP binding site [chemical binding]; other site 111781011268 substrate binding site [chemical binding]; other site 111781011269 activation loop (A-loop); other site 111781011270 GUN4-like; Region: GUN4; pfam05419 111781011271 agmatinase; Region: agmatinase; TIGR01230 111781011272 Agmatinase-like family; Region: Agmatinase-like; cd09990 111781011273 active site 111781011274 oligomer interface [polypeptide binding]; other site 111781011275 Mn binding site [ion binding]; other site 111781011276 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 111781011277 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 111781011278 Walker A/P-loop; other site 111781011279 ATP binding site [chemical binding]; other site 111781011280 Q-loop/lid; other site 111781011281 ABC transporter signature motif; other site 111781011282 Walker B; other site 111781011283 D-loop; other site 111781011284 H-loop/switch region; other site 111781011285 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 111781011286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 111781011287 dimer interface [polypeptide binding]; other site 111781011288 conserved gate region; other site 111781011289 putative PBP binding loops; other site 111781011290 ABC-ATPase subunit interface; other site 111781011291 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 111781011292 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 111781011293 hydrogenase accessory protein HypB; Region: hypB; TIGR00073 111781011294 hydrogenase nickel insertion protein HypA; Region: hypA; TIGR00100 111781011295 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 111781011296 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 111781011297 anthranilate synthase component I-like protein; Validated; Region: PRK05940 111781011298 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 111781011299 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 111781011300 CHASE3 domain; Region: CHASE3; pfam05227 111781011301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011302 dimer interface [polypeptide binding]; other site 111781011303 phosphorylation site [posttranslational modification] 111781011304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011305 ATP binding site [chemical binding]; other site 111781011306 Mg2+ binding site [ion binding]; other site 111781011307 G-X-G motif; other site 111781011308 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 111781011309 dimer interface [polypeptide binding]; other site 111781011310 [2Fe-2S] cluster binding site [ion binding]; other site 111781011311 Ycf27; Reviewed; Region: orf27; CHL00148 111781011312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011313 active site 111781011314 phosphorylation site [posttranslational modification] 111781011315 intermolecular recognition site; other site 111781011316 dimerization interface [polypeptide binding]; other site 111781011317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781011318 DNA binding site [nucleotide binding] 111781011319 DNA repair protein RadA; Provisional; Region: PRK11823 111781011320 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 111781011321 Walker A motif/ATP binding site; other site 111781011322 ATP binding site [chemical binding]; other site 111781011323 Walker B motif; other site 111781011324 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 111781011325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781011326 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781011327 metal binding site [ion binding]; metal-binding site 111781011328 active site 111781011329 I-site; other site 111781011330 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 111781011331 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 111781011332 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 111781011333 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 111781011334 Walker A/P-loop; other site 111781011335 ATP binding site [chemical binding]; other site 111781011336 Q-loop/lid; other site 111781011337 ABC transporter signature motif; other site 111781011338 Walker B; other site 111781011339 D-loop; other site 111781011340 H-loop/switch region; other site 111781011341 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781011342 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781011343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781011344 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011345 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781011346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011347 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011348 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011350 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 111781011351 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 111781011352 Walker A/P-loop; other site 111781011353 ATP binding site [chemical binding]; other site 111781011354 Q-loop/lid; other site 111781011355 ABC transporter signature motif; other site 111781011356 Walker B; other site 111781011357 D-loop; other site 111781011358 H-loop/switch region; other site 111781011359 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 111781011360 putative dimer interface [polypeptide binding]; other site 111781011361 putative [2Fe-2S] cluster binding site [ion binding]; other site 111781011362 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 111781011363 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 111781011364 siderophore binding site; other site 111781011365 AMIN domain; Region: AMIN; pfam11741 111781011366 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 111781011367 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 111781011368 N-terminal plug; other site 111781011369 ligand-binding site [chemical binding]; other site 111781011370 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 111781011371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 111781011372 inhibitor-cofactor binding pocket; inhibition site 111781011373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781011374 catalytic residue [active] 111781011375 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 111781011376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781011377 catalytic residue [active] 111781011378 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 111781011379 IucA / IucC family; Region: IucA_IucC; pfam04183 111781011380 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 111781011381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 111781011382 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 111781011383 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 111781011384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 111781011385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781011386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 111781011387 putative substrate translocation pore; other site 111781011388 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 111781011389 IucA / IucC family; Region: IucA_IucC; pfam04183 111781011390 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 111781011391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 111781011392 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 111781011393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 111781011394 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 111781011395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 111781011396 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 111781011397 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 111781011398 active site 111781011399 TDP-binding site; other site 111781011400 acceptor substrate-binding pocket; other site 111781011401 homodimer interface [polypeptide binding]; other site 111781011402 acyl carrier protein; Provisional; Region: PRK07081 111781011403 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 111781011404 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 111781011405 dimer interface [polypeptide binding]; other site 111781011406 active site 111781011407 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 111781011408 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 111781011409 dimer interface [polypeptide binding]; other site 111781011410 active site 111781011411 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 111781011412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781011413 active site 111781011414 Protein of unknown function, DUF547; Region: DUF547; pfam04784 111781011415 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 111781011416 Ligand binding site; other site 111781011417 Putative Catalytic site; other site 111781011418 DXD motif; other site 111781011419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011420 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011421 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011423 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 111781011424 active site 111781011425 NTP binding site [chemical binding]; other site 111781011426 metal binding triad [ion binding]; metal-binding site 111781011427 antibiotic binding site [chemical binding]; other site 111781011428 4-alpha-glucanotransferase; Provisional; Region: PRK14508 111781011429 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 111781011430 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 111781011431 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 111781011432 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 111781011433 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 111781011434 5S rRNA interface [nucleotide binding]; other site 111781011435 CTC domain interface [polypeptide binding]; other site 111781011436 L16 interface [polypeptide binding]; other site 111781011437 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 111781011438 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 111781011439 GDP-binding site [chemical binding]; other site 111781011440 ACT binding site; other site 111781011441 IMP binding site; other site 111781011442 dihydrodipicolinate reductase; Provisional; Region: PRK00048 111781011443 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 111781011444 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 111781011445 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 111781011446 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 111781011447 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 111781011448 active site 111781011449 (T/H)XGH motif; other site 111781011450 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 111781011451 O-Antigen ligase; Region: Wzy_C; pfam04932 111781011452 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 111781011453 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 111781011454 TPR repeat; Region: TPR_11; pfam13414 111781011455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781011456 binding surface 111781011457 TPR motif; other site 111781011458 TPR repeat; Region: TPR_11; pfam13414 111781011459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781011460 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 111781011461 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 111781011462 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 111781011463 putative active site [active] 111781011464 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 111781011465 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 111781011466 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 111781011467 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 111781011468 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 111781011469 ATP-grasp domain; Region: ATP-grasp_4; cl17255 111781011470 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 111781011471 IMP binding site; other site 111781011472 dimer interface [polypeptide binding]; other site 111781011473 interdomain contacts; other site 111781011474 partial ornithine binding site; other site 111781011475 TIR domain; Region: TIR_2; pfam13676 111781011476 TIR domain; Region: TIR_2; pfam13676 111781011477 TIR domain; Region: TIR_2; pfam13676 111781011478 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781011479 WD domain, G-beta repeat; Region: WD40; pfam00400 111781011480 WD domain, G-beta repeat; Region: WD40; pfam00400 111781011481 WD domain, G-beta repeat; Region: WD40; pfam00400 111781011482 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781011483 structural tetrad; other site 111781011484 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781011485 structural tetrad; other site 111781011486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781011487 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781011488 ligand binding site [chemical binding]; other site 111781011489 flexible hinge region; other site 111781011490 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 111781011491 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 111781011492 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 111781011493 argininosuccinate lyase; Provisional; Region: PRK00855 111781011494 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 111781011495 active sites [active] 111781011496 tetramer interface [polypeptide binding]; other site 111781011497 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 111781011498 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 111781011499 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 111781011500 phosphatidate cytidylyltransferase; Region: PLN02953 111781011501 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 111781011502 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 111781011503 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 111781011504 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 111781011505 Tetramer interface [polypeptide binding]; other site 111781011506 active site 111781011507 FMN-binding site [chemical binding]; other site 111781011508 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 111781011509 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 111781011510 putative active site [active] 111781011511 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781011512 CHASE2 domain; Region: CHASE2; pfam05226 111781011513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011514 dimer interface [polypeptide binding]; other site 111781011515 phosphorylation site [posttranslational modification] 111781011516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011517 ATP binding site [chemical binding]; other site 111781011518 Mg2+ binding site [ion binding]; other site 111781011519 G-X-G motif; other site 111781011520 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781011521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781011522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 111781011523 binding surface 111781011524 TPR motif; other site 111781011525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781011526 Transcriptional regulator [Transcription]; Region: LytR; COG1316 111781011527 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 111781011528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781011529 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 111781011530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781011531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781011532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781011533 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 111781011534 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 111781011535 putative hexamer interface [polypeptide binding]; other site 111781011536 putative hexagonal pore; other site 111781011537 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 111781011538 putative hexamer interface [polypeptide binding]; other site 111781011539 putative hexagonal pore; other site 111781011540 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 111781011541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781011542 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781011543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781011544 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 111781011545 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 111781011546 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 111781011547 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 111781011548 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 111781011549 dimer interface [polypeptide binding]; other site 111781011550 decamer (pentamer of dimers) interface [polypeptide binding]; other site 111781011551 catalytic triad [active] 111781011552 peroxidatic and resolving cysteines [active] 111781011553 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781011554 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781011555 ligand binding site [chemical binding]; other site 111781011556 flexible hinge region; other site 111781011557 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 111781011558 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 111781011559 TRAM domain; Region: TRAM; pfam01938 111781011560 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 111781011561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 111781011562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781011563 S-adenosylmethionine binding site [chemical binding]; other site 111781011564 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 111781011565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 111781011566 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 111781011567 Short C-terminal domain; Region: SHOCT; pfam09851 111781011568 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 111781011569 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 111781011570 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 111781011571 Lipopolysaccharide-assembly; Region: LptE; cl01125 111781011572 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 111781011573 AAA domain; Region: AAA_33; pfam13671 111781011574 ligand-binding site [chemical binding]; other site 111781011575 TIGR03032 family protein; Region: TIGR03032 111781011576 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 111781011577 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 111781011578 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 111781011579 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 111781011580 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 111781011581 DRTGG domain; Region: DRTGG; pfam07085 111781011582 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 111781011583 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 111781011584 FMN binding site [chemical binding]; other site 111781011585 active site 111781011586 catalytic residues [active] 111781011587 substrate binding site [chemical binding]; other site 111781011588 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781011589 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 111781011590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 111781011591 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011593 active site 111781011594 phosphorylation site [posttranslational modification] 111781011595 intermolecular recognition site; other site 111781011596 dimerization interface [polypeptide binding]; other site 111781011597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781011598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781011599 metal binding site [ion binding]; metal-binding site 111781011600 active site 111781011601 I-site; other site 111781011602 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011604 active site 111781011605 phosphorylation site [posttranslational modification] 111781011606 intermolecular recognition site; other site 111781011607 dimerization interface [polypeptide binding]; other site 111781011608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011609 dimer interface [polypeptide binding]; other site 111781011610 phosphorylation site [posttranslational modification] 111781011611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011612 ATP binding site [chemical binding]; other site 111781011613 Mg2+ binding site [ion binding]; other site 111781011614 G-X-G motif; other site 111781011615 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 111781011616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 111781011617 substrate binding pocket [chemical binding]; other site 111781011618 membrane-bound complex binding site; other site 111781011619 hinge residues; other site 111781011620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011621 dimer interface [polypeptide binding]; other site 111781011622 phosphorylation site [posttranslational modification] 111781011623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011624 ATP binding site [chemical binding]; other site 111781011625 Mg2+ binding site [ion binding]; other site 111781011626 G-X-G motif; other site 111781011627 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011629 active site 111781011630 phosphorylation site [posttranslational modification] 111781011631 intermolecular recognition site; other site 111781011632 dimerization interface [polypeptide binding]; other site 111781011633 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011635 active site 111781011636 phosphorylation site [posttranslational modification] 111781011637 intermolecular recognition site; other site 111781011638 dimerization interface [polypeptide binding]; other site 111781011639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781011640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781011641 metal binding site [ion binding]; metal-binding site 111781011642 active site 111781011643 I-site; other site 111781011644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781011645 MASE1; Region: MASE1; pfam05231 111781011646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011647 dimer interface [polypeptide binding]; other site 111781011648 phosphorylation site [posttranslational modification] 111781011649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011650 ATP binding site [chemical binding]; other site 111781011651 Mg2+ binding site [ion binding]; other site 111781011652 G-X-G motif; other site 111781011653 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011655 active site 111781011656 phosphorylation site [posttranslational modification] 111781011657 intermolecular recognition site; other site 111781011658 dimerization interface [polypeptide binding]; other site 111781011659 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 111781011660 Protein export membrane protein; Region: SecD_SecF; cl14618 111781011661 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 111781011662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 111781011663 HlyD family secretion protein; Region: HlyD_3; pfam13437 111781011664 Predicted transcriptional regulators [Transcription]; Region: COG1695 111781011665 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 111781011666 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 111781011667 Caspase domain; Region: Peptidase_C14; pfam00656 111781011668 Domain of unknown function DUF39; Region: DUF39; pfam01837 111781011669 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 111781011670 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 111781011671 putative catalytic cysteine [active] 111781011672 Bacterial SH3 domain; Region: SH3_3; cl17532 111781011673 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 111781011674 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 111781011675 active site 111781011676 metal binding site [ion binding]; metal-binding site 111781011677 FcoT-like thioesterase domain; Region: FcoT; pfam10862 111781011678 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 111781011679 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 111781011680 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 111781011681 Walker A/P-loop; other site 111781011682 ATP binding site [chemical binding]; other site 111781011683 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 111781011684 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 111781011685 dimer interface [polypeptide binding]; other site 111781011686 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 111781011687 ABC transporter signature motif; other site 111781011688 Walker B; other site 111781011689 D-loop; other site 111781011690 H-loop/switch region; other site 111781011691 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 111781011692 Ion channel; Region: Ion_trans_2; pfam07885 111781011693 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 111781011694 TrkA-N domain; Region: TrkA_N; pfam02254 111781011695 TrkA-C domain; Region: TrkA_C; pfam02080 111781011696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011697 Homeodomain-like domain; Region: HTH_32; pfam13565 111781011698 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011701 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011702 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011704 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 111781011705 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 111781011706 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 111781011707 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 111781011708 active site 111781011709 GTPase Era; Reviewed; Region: era; PRK00089 111781011710 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 111781011711 G1 box; other site 111781011712 GTP/Mg2+ binding site [chemical binding]; other site 111781011713 Switch I region; other site 111781011714 G2 box; other site 111781011715 Switch II region; other site 111781011716 G3 box; other site 111781011717 G4 box; other site 111781011718 G5 box; other site 111781011719 KH domain; Region: KH_2; pfam07650 111781011720 KH domain; Region: KH_4; pfam13083 111781011721 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 111781011722 G-X-X-G motif; other site 111781011723 ribosomal protein S16; Region: rps16; CHL00005 111781011724 Protein of unknown function (DUF98); Region: DUF98; pfam01947 111781011725 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 111781011726 active site 111781011727 zinc binding site [ion binding]; other site 111781011728 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 111781011729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781011730 NAD(P) binding site [chemical binding]; other site 111781011731 active site 111781011732 cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153 111781011733 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 111781011734 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 111781011735 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 111781011736 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 111781011737 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 111781011738 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 111781011739 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 111781011740 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 111781011741 active site 111781011742 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 111781011743 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 111781011744 dimer interface [polypeptide binding]; other site 111781011745 active site 111781011746 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 111781011747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 111781011748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 111781011749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 111781011750 dimerization interface [polypeptide binding]; other site 111781011751 L-aspartate oxidase; Provisional; Region: PRK07395 111781011752 L-aspartate oxidase; Provisional; Region: PRK06175 111781011753 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 111781011754 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 111781011755 AMP binding site [chemical binding]; other site 111781011756 metal binding site [ion binding]; metal-binding site 111781011757 active site 111781011758 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 111781011759 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 111781011760 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 111781011761 ATP cone domain; Region: ATP-cone; pfam03477 111781011762 Class I ribonucleotide reductase; Region: RNR_I; cd01679 111781011763 active site 111781011764 dimer interface [polypeptide binding]; other site 111781011765 catalytic residues [active] 111781011766 effector binding site; other site 111781011767 R2 peptide binding site; other site 111781011768 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 111781011769 NADPH bind site [chemical binding]; other site 111781011770 putative FMN binding site [chemical binding]; other site 111781011771 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 111781011772 putative FMN binding site [chemical binding]; other site 111781011773 NADPH bind site [chemical binding]; other site 111781011774 Uncharacterized conserved protein [Function unknown]; Region: COG1262 111781011775 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 111781011776 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781011777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781011778 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011779 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781011780 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 111781011781 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 111781011782 intersubunit interface [polypeptide binding]; other site 111781011783 active site 111781011784 zinc binding site [ion binding]; other site 111781011785 Na+ binding site [ion binding]; other site 111781011786 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 111781011787 SmpB-tmRNA interface; other site 111781011788 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 111781011789 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 111781011790 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 111781011791 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 111781011792 active site 111781011793 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 111781011794 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 111781011795 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 111781011796 cell division topological specificity factor MinE; Provisional; Region: PRK13988 111781011797 septum site-determining protein MinD; Region: minD_bact; TIGR01968 111781011798 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 111781011799 Switch I; other site 111781011800 Switch II; other site 111781011801 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 111781011802 aspartate aminotransferase; Provisional; Region: PRK05764 111781011803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 111781011804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781011805 homodimer interface [polypeptide binding]; other site 111781011806 catalytic residue [active] 111781011807 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 111781011808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 111781011809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781011810 homodimer interface [polypeptide binding]; other site 111781011811 catalytic residue [active] 111781011812 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781011813 CHASE2 domain; Region: CHASE2; pfam05226 111781011814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781011815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781011816 metal binding site [ion binding]; metal-binding site 111781011817 active site 111781011818 I-site; other site 111781011819 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781011820 cell division protein; Validated; Region: ftsH; CHL00176 111781011821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 111781011822 Walker A motif; other site 111781011823 ATP binding site [chemical binding]; other site 111781011824 Walker B motif; other site 111781011825 arginine finger; other site 111781011826 Peptidase family M41; Region: Peptidase_M41; pfam01434 111781011827 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 111781011828 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 111781011829 molybdopterin cofactor binding site; other site 111781011830 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 111781011831 molybdopterin cofactor binding site; other site 111781011832 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 111781011833 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 111781011834 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 111781011835 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 111781011836 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 111781011837 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 111781011838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781011839 Coenzyme A binding pocket [chemical binding]; other site 111781011840 Late competence development protein ComFB; Region: ComFB; pfam10719 111781011841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781011842 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 111781011843 active site 111781011844 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 111781011845 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 111781011846 ligand binding site [chemical binding]; other site 111781011847 flexible hinge region; other site 111781011848 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 111781011849 putative switch regulator; other site 111781011850 non-specific DNA interactions [nucleotide binding]; other site 111781011851 DNA binding site [nucleotide binding] 111781011852 sequence specific DNA binding site [nucleotide binding]; other site 111781011853 putative cAMP binding site [chemical binding]; other site 111781011854 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 111781011855 phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098 111781011856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 111781011857 S-adenosylmethionine binding site [chemical binding]; other site 111781011858 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 111781011859 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 111781011860 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 111781011861 FAD binding domain; Region: FAD_binding_4; pfam01565 111781011862 TIR domain; Region: TIR_2; pfam13676 111781011863 TIR domain; Region: TIR_2; pfam13676 111781011864 TIR domain; Region: TIR_2; pfam13676 111781011865 TIR domain; Region: TIR_2; pfam13676 111781011866 TIR domain; Region: TIR_2; pfam13676 111781011867 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781011868 structural tetrad; other site 111781011869 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781011870 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781011871 structural tetrad; other site 111781011872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011873 Homeodomain-like domain; Region: HTH_32; pfam13565 111781011874 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781011877 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781011878 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781011879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781011880 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 111781011881 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 111781011882 G1 box; other site 111781011883 putative GEF interaction site [polypeptide binding]; other site 111781011884 GTP/Mg2+ binding site [chemical binding]; other site 111781011885 Switch I region; other site 111781011886 G2 box; other site 111781011887 G3 box; other site 111781011888 Switch II region; other site 111781011889 G4 box; other site 111781011890 G5 box; other site 111781011891 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 111781011892 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 111781011893 Cache domain; Region: Cache_1; pfam02743 111781011894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781011895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781011896 dimerization interface [polypeptide binding]; other site 111781011897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011898 dimer interface [polypeptide binding]; other site 111781011899 phosphorylation site [posttranslational modification] 111781011900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011901 ATP binding site [chemical binding]; other site 111781011902 Mg2+ binding site [ion binding]; other site 111781011903 G-X-G motif; other site 111781011904 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781011905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011906 active site 111781011907 phosphorylation site [posttranslational modification] 111781011908 intermolecular recognition site; other site 111781011909 dimerization interface [polypeptide binding]; other site 111781011910 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 111781011911 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 111781011912 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 111781011913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 111781011914 Coenzyme A binding pocket [chemical binding]; other site 111781011915 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781011916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011917 active site 111781011918 phosphorylation site [posttranslational modification] 111781011919 intermolecular recognition site; other site 111781011920 dimerization interface [polypeptide binding]; other site 111781011921 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781011922 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781011923 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781011924 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781011925 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 111781011926 cyclase homology domain; Region: CHD; cd07302 111781011927 nucleotidyl binding site; other site 111781011928 metal binding site [ion binding]; metal-binding site 111781011929 dimer interface [polypeptide binding]; other site 111781011930 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 111781011931 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 111781011932 domain interfaces; other site 111781011933 active site 111781011934 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 111781011935 4Fe-4S binding domain; Region: Fer4; pfam00037 111781011936 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 111781011937 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 111781011938 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 111781011939 Uncharacterized conserved protein [Function unknown]; Region: COG1434 111781011940 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 111781011941 putative active site [active] 111781011942 photosystem I P700 chlorophyll a apoprotein A2; Region: psaB; CHL00054 111781011943 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 111781011944 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 111781011945 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 111781011946 photosystem II 44 kDa protein; Region: psbC; CHL00035 111781011947 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 111781011948 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 111781011949 D1 interface; other site 111781011950 chlorophyll binding site; other site 111781011951 pheophytin binding site; other site 111781011952 beta carotene binding site; other site 111781011953 cytochrome b559 beta interface; other site 111781011954 quinone binding site; other site 111781011955 cytochrome b559 alpha interface; other site 111781011956 protein J interface; other site 111781011957 protein H interface; other site 111781011958 protein X interface; other site 111781011959 core light harvesting protein interface; other site 111781011960 protein L interface; other site 111781011961 CP43 interface; other site 111781011962 protein T interface; other site 111781011963 Fe binding site [ion binding]; other site 111781011964 protein M interface; other site 111781011965 Mn-stabilizing polypeptide interface; other site 111781011966 bromide binding site; other site 111781011967 cytochrome c-550 interface; other site 111781011968 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 111781011969 homotrimer interface [polypeptide binding]; other site 111781011970 Walker A motif; other site 111781011971 GTP binding site [chemical binding]; other site 111781011972 Walker B motif; other site 111781011973 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 111781011974 active site 111781011975 catalytic site [active] 111781011976 substrate binding site [chemical binding]; other site 111781011977 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 111781011978 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 111781011979 Uncharacterized conserved protein [Function unknown]; Region: COG0398 111781011980 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 111781011981 Uncharacterized conserved protein [Function unknown]; Region: COG0398 111781011982 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 111781011983 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 111781011984 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 111781011985 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781011986 CHASE2 domain; Region: CHASE2; pfam05226 111781011987 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 111781011988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781011989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781011990 dimer interface [polypeptide binding]; other site 111781011991 phosphorylation site [posttranslational modification] 111781011992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781011993 ATP binding site [chemical binding]; other site 111781011994 Mg2+ binding site [ion binding]; other site 111781011995 G-X-G motif; other site 111781011996 Response regulator receiver domain; Region: Response_reg; pfam00072 111781011997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781011998 active site 111781011999 phosphorylation site [posttranslational modification] 111781012000 intermolecular recognition site; other site 111781012001 dimerization interface [polypeptide binding]; other site 111781012002 HEAT repeats; Region: HEAT_2; pfam13646 111781012003 HEAT repeats; Region: HEAT_2; pfam13646 111781012004 HEAT repeats; Region: HEAT_2; pfam13646 111781012005 hypothetical protein; Provisional; Region: PRK07394 111781012006 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 111781012007 threonine dehydratase; Reviewed; Region: PRK09224 111781012008 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 111781012009 tetramer interface [polypeptide binding]; other site 111781012010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781012011 catalytic residue [active] 111781012012 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 111781012013 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 111781012014 putative Ile/Val binding site [chemical binding]; other site 111781012015 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781012016 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 111781012017 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 111781012018 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 111781012019 catalytic residues [active] 111781012020 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 111781012021 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781012022 P-loop; other site 111781012023 Magnesium ion binding site [ion binding]; other site 111781012024 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 111781012025 Magnesium ion binding site [ion binding]; other site 111781012026 Ycf27; Reviewed; Region: orf27; CHL00148 111781012027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781012028 active site 111781012029 phosphorylation site [posttranslational modification] 111781012030 intermolecular recognition site; other site 111781012031 dimerization interface [polypeptide binding]; other site 111781012032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 111781012033 DNA binding site [nucleotide binding] 111781012034 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 111781012035 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 111781012036 RNA binding site [nucleotide binding]; other site 111781012037 active site 111781012038 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 111781012039 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 111781012040 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 111781012041 Flavoprotein; Region: Flavoprotein; pfam02441 111781012042 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 111781012043 Predicted acetyltransferase [General function prediction only]; Region: COG3153 111781012044 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 111781012045 CTP synthetase; Validated; Region: pyrG; PRK05380 111781012046 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 111781012047 Catalytic site [active] 111781012048 active site 111781012049 UTP binding site [chemical binding]; other site 111781012050 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 111781012051 active site 111781012052 putative oxyanion hole; other site 111781012053 catalytic triad [active] 111781012054 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 111781012055 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 111781012056 THF binding site; other site 111781012057 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 111781012058 substrate binding site [chemical binding]; other site 111781012059 THF binding site; other site 111781012060 zinc-binding site [ion binding]; other site 111781012061 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 111781012062 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 111781012063 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 111781012064 shikimate binding site; other site 111781012065 NAD(P) binding site [chemical binding]; other site 111781012066 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 111781012067 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 111781012068 Ligand binding site; other site 111781012069 Putative Catalytic site; other site 111781012070 DXD motif; other site 111781012071 DNA gyrase subunit A; Validated; Region: PRK05560 111781012072 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 111781012073 CAP-like domain; other site 111781012074 active site 111781012075 primary dimer interface [polypeptide binding]; other site 111781012076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781012077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781012078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781012079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781012080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781012081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 111781012082 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 111781012083 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 111781012084 Competence protein; Region: Competence; pfam03772 111781012085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781012086 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 111781012087 putative active site [active] 111781012088 heme pocket [chemical binding]; other site 111781012089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781012090 putative active site [active] 111781012091 heme pocket [chemical binding]; other site 111781012092 GAF domain; Region: GAF_2; pfam13185 111781012093 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781012094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781012095 metal binding site [ion binding]; metal-binding site 111781012096 active site 111781012097 I-site; other site 111781012098 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 111781012099 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 111781012100 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 111781012101 N-terminal plug; other site 111781012102 ligand-binding site [chemical binding]; other site 111781012103 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 111781012104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 111781012105 active site 111781012106 metal binding site [ion binding]; metal-binding site 111781012107 hexamer interface [polypeptide binding]; other site 111781012108 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 111781012109 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 111781012110 putative ligand binding site [chemical binding]; other site 111781012111 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 111781012112 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 111781012113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 111781012114 dimer interface [polypeptide binding]; other site 111781012115 putative PBP binding regions; other site 111781012116 ABC-ATPase subunit interface; other site 111781012117 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 111781012118 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 111781012119 active site 111781012120 catalytic residues [active] 111781012121 metal binding site [ion binding]; metal-binding site 111781012122 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 111781012123 Thf1-like protein; Reviewed; Region: PRK13266 111781012124 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 111781012125 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 111781012126 core domain interface [polypeptide binding]; other site 111781012127 delta subunit interface [polypeptide binding]; other site 111781012128 epsilon subunit interface [polypeptide binding]; other site 111781012129 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 111781012130 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 111781012131 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 111781012132 beta subunit interaction interface [polypeptide binding]; other site 111781012133 Walker A motif; other site 111781012134 ATP binding site [chemical binding]; other site 111781012135 Walker B motif; other site 111781012136 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 111781012137 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 111781012138 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 111781012139 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 111781012140 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 111781012141 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 111781012142 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 111781012143 ATP synthase CF0 C subunit; Region: atpH; CHL00061 111781012144 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 111781012145 ATP synthase CF0 A subunit; Region: atpI; CHL00046 111781012146 ATP synthase I chain; Region: ATP_synt_I; pfam03899 111781012147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 111781012148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 111781012149 active site 111781012150 catalytic tetrad [active] 111781012151 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 111781012152 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 111781012153 putative C-terminal domain interface [polypeptide binding]; other site 111781012154 putative GSH binding site (G-site) [chemical binding]; other site 111781012155 putative dimer interface [polypeptide binding]; other site 111781012156 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 111781012157 N-terminal domain interface [polypeptide binding]; other site 111781012158 dimer interface [polypeptide binding]; other site 111781012159 substrate binding pocket (H-site) [chemical binding]; other site 111781012160 elongation factor G; Reviewed; Region: PRK00007 111781012161 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 111781012162 G1 box; other site 111781012163 putative GEF interaction site [polypeptide binding]; other site 111781012164 GTP/Mg2+ binding site [chemical binding]; other site 111781012165 Switch I region; other site 111781012166 G2 box; other site 111781012167 G3 box; other site 111781012168 Switch II region; other site 111781012169 G4 box; other site 111781012170 G5 box; other site 111781012171 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 111781012172 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 111781012173 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 111781012174 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 111781012175 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 111781012176 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 111781012177 putative binding surface; other site 111781012178 active site 111781012179 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 111781012180 DNA polymerase III subunit beta; Validated; Region: PRK05643 111781012181 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 111781012182 putative DNA binding surface [nucleotide binding]; other site 111781012183 dimer interface [polypeptide binding]; other site 111781012184 beta-clamp/clamp loader binding surface; other site 111781012185 beta-clamp/translesion DNA polymerase binding surface; other site 111781012186 CP12 domain; Region: CP12; pfam02672 111781012187 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 111781012188 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781012189 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781012190 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781012191 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781012192 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781012193 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781012194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781012195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781012196 dimer interface [polypeptide binding]; other site 111781012197 phosphorylation site [posttranslational modification] 111781012198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781012199 ATP binding site [chemical binding]; other site 111781012200 Mg2+ binding site [ion binding]; other site 111781012201 G-X-G motif; other site 111781012202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781012203 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 111781012204 putative active site [active] 111781012205 heme pocket [chemical binding]; other site 111781012206 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 111781012207 putative active site [active] 111781012208 heme pocket [chemical binding]; other site 111781012209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 111781012210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781012211 ATP binding site [chemical binding]; other site 111781012212 Mg2+ binding site [ion binding]; other site 111781012213 G-X-G motif; other site 111781012214 aspartate kinase; Provisional; Region: PRK07431 111781012215 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 111781012216 putative catalytic residues [active] 111781012217 putative nucleotide binding site [chemical binding]; other site 111781012218 putative aspartate binding site [chemical binding]; other site 111781012219 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 111781012220 putative allosteric regulatory site; other site 111781012221 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 111781012222 putative allosteric regulatory residue; other site 111781012223 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 111781012224 putative allosteric regulatory site; other site 111781012225 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 111781012226 putative allosteric regulatory residue; other site 111781012227 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 111781012228 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 111781012229 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 111781012230 tetramer (dimer of dimers) interface [polypeptide binding]; other site 111781012231 active site 111781012232 dimer interface [polypeptide binding]; other site 111781012233 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 111781012234 RuvA N terminal domain; Region: RuvA_N; pfam01330 111781012235 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 111781012236 replicative DNA helicase; Region: DnaB; TIGR00665 111781012237 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 111781012238 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 111781012239 Walker A motif; other site 111781012240 ATP binding site [chemical binding]; other site 111781012241 Walker B motif; other site 111781012242 DNA binding loops [nucleotide binding] 111781012243 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 111781012244 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 111781012245 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 111781012246 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 111781012247 dihydrodipicolinate synthase; Region: dapA; TIGR00674 111781012248 dimer interface [polypeptide binding]; other site 111781012249 active site 111781012250 catalytic residue [active] 111781012251 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 111781012252 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 111781012253 trigger factor; Provisional; Region: tig; PRK01490 111781012254 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 111781012255 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 111781012256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 111781012257 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 111781012258 H+ Antiporter protein; Region: 2A0121; TIGR00900 111781012259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 111781012260 Peptidase family M48; Region: Peptidase_M48; cl12018 111781012261 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 111781012262 putative binding surface; other site 111781012263 active site 111781012264 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 111781012265 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 111781012266 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 111781012267 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 111781012268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 111781012269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 111781012270 dimerization interface [polypeptide binding]; other site 111781012271 PAS domain; Region: PAS; smart00091 111781012272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781012273 dimer interface [polypeptide binding]; other site 111781012274 phosphorylation site [posttranslational modification] 111781012275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781012276 ATP binding site [chemical binding]; other site 111781012277 Mg2+ binding site [ion binding]; other site 111781012278 G-X-G motif; other site 111781012279 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 111781012280 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 111781012281 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 111781012282 MPN+ (JAMM) motif; other site 111781012283 Zinc-binding site [ion binding]; other site 111781012284 threonine synthase; Reviewed; Region: PRK06721 111781012285 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 111781012286 homodimer interface [polypeptide binding]; other site 111781012287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 111781012288 catalytic residue [active] 111781012289 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 111781012290 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 111781012291 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 111781012292 UbiA prenyltransferase family; Region: UbiA; pfam01040 111781012293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 111781012294 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 111781012295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 111781012296 putative active site [active] 111781012297 heme pocket [chemical binding]; other site 111781012298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781012299 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781012300 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 111781012301 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 111781012302 HIGH motif; other site 111781012303 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 111781012304 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 111781012305 active site 111781012306 KMSKS motif; other site 111781012307 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 111781012308 tRNA binding surface [nucleotide binding]; other site 111781012309 anticodon binding site; other site 111781012310 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 111781012311 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 111781012312 transketolase; Region: PLN02790 111781012313 TPP-binding site [chemical binding]; other site 111781012314 dimer interface [polypeptide binding]; other site 111781012315 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 111781012316 PYR/PP interface [polypeptide binding]; other site 111781012317 dimer interface [polypeptide binding]; other site 111781012318 TPP binding site [chemical binding]; other site 111781012319 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 111781012320 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 111781012321 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 111781012322 dimer interface [polypeptide binding]; other site 111781012323 active site 111781012324 acyl carrier protein; Provisional; Region: acpP; PRK00982 111781012325 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 111781012326 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 111781012327 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 111781012328 peripheral dimer interface [polypeptide binding]; other site 111781012329 core dimer interface [polypeptide binding]; other site 111781012330 L10 interface [polypeptide binding]; other site 111781012331 L11 interface [polypeptide binding]; other site 111781012332 putative EF-Tu interaction site [polypeptide binding]; other site 111781012333 putative EF-G interaction site [polypeptide binding]; other site 111781012334 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 111781012335 23S rRNA interface [nucleotide binding]; other site 111781012336 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 111781012337 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 111781012338 mRNA/rRNA interface [nucleotide binding]; other site 111781012339 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 111781012340 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 111781012341 23S rRNA interface [nucleotide binding]; other site 111781012342 L7/L12 interface [polypeptide binding]; other site 111781012343 putative thiostrepton binding site; other site 111781012344 L25 interface [polypeptide binding]; other site 111781012345 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 111781012346 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 111781012347 putative homodimer interface [polypeptide binding]; other site 111781012348 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 111781012349 heterodimer interface [polypeptide binding]; other site 111781012350 homodimer interface [polypeptide binding]; other site 111781012351 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 111781012352 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 111781012353 S-layer homology domain; Region: SLH; pfam00395 111781012354 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 111781012355 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 111781012356 proline aminopeptidase P II; Provisional; Region: PRK10879 111781012357 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 111781012358 active site 111781012359 peptide chain release factor 1; Validated; Region: prfA; PRK00591 111781012360 This domain is found in peptide chain release factors; Region: PCRF; smart00937 111781012361 RF-1 domain; Region: RF-1; pfam00472 111781012362 ribosomal protein L31; Validated; Region: rpl31; CHL00136 111781012363 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 111781012364 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 111781012365 23S rRNA interface [nucleotide binding]; other site 111781012366 L3 interface [polypeptide binding]; other site 111781012367 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 111781012368 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 111781012369 dimerization interface 3.5A [polypeptide binding]; other site 111781012370 active site 111781012371 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 111781012372 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 111781012373 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 111781012374 alphaNTD homodimer interface [polypeptide binding]; other site 111781012375 alphaNTD - beta interaction site [polypeptide binding]; other site 111781012376 alphaNTD - beta' interaction site [polypeptide binding]; other site 111781012377 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 111781012378 30S ribosomal protein S11; Validated; Region: PRK05309 111781012379 ribosomal protein S13; Validated; Region: rps13; CHL00137 111781012380 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 111781012381 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 111781012382 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 111781012383 rRNA binding site [nucleotide binding]; other site 111781012384 predicted 30S ribosome binding site; other site 111781012385 adenylate kinase; Provisional; Region: adk; PRK02496 111781012386 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 111781012387 AMP-binding site [chemical binding]; other site 111781012388 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 111781012389 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 111781012390 SecY translocase; Region: SecY; pfam00344 111781012391 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 111781012392 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 111781012393 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 111781012394 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 111781012395 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 111781012396 23S rRNA interface [nucleotide binding]; other site 111781012397 L21e interface [polypeptide binding]; other site 111781012398 5S rRNA interface [nucleotide binding]; other site 111781012399 L27 interface [polypeptide binding]; other site 111781012400 L5 interface [polypeptide binding]; other site 111781012401 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 111781012402 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 111781012403 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 111781012404 ribosomal protein S8; Region: rps8; CHL00042 111781012405 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 111781012406 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 111781012407 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 111781012408 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 111781012409 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 111781012410 RNA binding site [nucleotide binding]; other site 111781012411 ribosomal protein L14; Region: rpl14; CHL00057 111781012412 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 111781012413 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 111781012414 putative translocon interaction site; other site 111781012415 23S rRNA interface [nucleotide binding]; other site 111781012416 signal recognition particle (SRP54) interaction site; other site 111781012417 L23 interface [polypeptide binding]; other site 111781012418 trigger factor interaction site; other site 111781012419 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 111781012420 23S rRNA interface [nucleotide binding]; other site 111781012421 5S rRNA interface [nucleotide binding]; other site 111781012422 putative antibiotic binding site [chemical binding]; other site 111781012423 L25 interface [polypeptide binding]; other site 111781012424 L27 interface [polypeptide binding]; other site 111781012425 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 111781012426 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 111781012427 G-X-X-G motif; other site 111781012428 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 111781012429 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 111781012430 putative translocon binding site; other site 111781012431 protein-rRNA interface [nucleotide binding]; other site 111781012432 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 111781012433 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 111781012434 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 111781012435 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 111781012436 ribosomal protein L23; Region: rpl23; CHL00030 111781012437 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 111781012438 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 111781012439 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 111781012440 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 111781012441 RNase E interface [polypeptide binding]; other site 111781012442 trimer interface [polypeptide binding]; other site 111781012443 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 111781012444 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 111781012445 RNase E interface [polypeptide binding]; other site 111781012446 trimer interface [polypeptide binding]; other site 111781012447 active site 111781012448 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 111781012449 putative nucleic acid binding region [nucleotide binding]; other site 111781012450 G-X-X-G motif; other site 111781012451 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 111781012452 RNA binding site [nucleotide binding]; other site 111781012453 domain interface; other site 111781012454 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 111781012455 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 111781012456 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 111781012457 TMP-binding site; other site 111781012458 ATP-binding site [chemical binding]; other site 111781012459 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 111781012460 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 111781012461 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 111781012462 Response regulator receiver domain; Region: Response_reg; pfam00072 111781012463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781012464 active site 111781012465 phosphorylation site [posttranslational modification] 111781012466 intermolecular recognition site; other site 111781012467 dimerization interface [polypeptide binding]; other site 111781012468 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 111781012469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 111781012470 metal binding site [ion binding]; metal-binding site 111781012471 active site 111781012472 I-site; other site 111781012473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 111781012474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 111781012475 TIR domain; Region: TIR_2; pfam13676 111781012476 TIR domain; Region: TIR_2; pfam13676 111781012477 TIR domain; Region: TIR_2; pfam13676 111781012478 TIR domain; Region: TIR_2; pfam13676 111781012479 TIR domain; Region: TIR_2; pfam13676 111781012480 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781012481 structural tetrad; other site 111781012482 FOG: WD40 repeat [General function prediction only]; Region: COG2319 111781012483 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 111781012484 structural tetrad; other site 111781012485 WD40 repeats; Region: WD40; smart00320 111781012486 Protein of unknown function (DUF917); Region: DUF917; cl17829 111781012487 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 111781012488 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 111781012489 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 111781012490 Chromate transporter; Region: Chromate_transp; pfam02417 111781012491 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 111781012492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 111781012493 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 111781012494 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 111781012495 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 111781012496 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 111781012497 Predicted permeases [General function prediction only]; Region: COG0795 111781012498 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 111781012499 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 111781012500 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 111781012501 catalytic residue [active] 111781012502 putative FPP diphosphate binding site; other site 111781012503 putative FPP binding hydrophobic cleft; other site 111781012504 dimer interface [polypeptide binding]; other site 111781012505 putative IPP diphosphate binding site; other site 111781012506 Uncharacterized conserved protein [Function unknown]; Region: COG1624 111781012507 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 111781012508 diaminopimelate decarboxylase; Region: lysA; TIGR01048 111781012509 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 111781012510 active site 111781012511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 111781012512 substrate binding site [chemical binding]; other site 111781012513 catalytic residues [active] 111781012514 dimer interface [polypeptide binding]; other site 111781012515 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 111781012516 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 111781012517 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 111781012518 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 111781012519 ligand binding site; other site 111781012520 oligomer interface; other site 111781012521 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 111781012522 dimer interface [polypeptide binding]; other site 111781012523 N-terminal domain interface [polypeptide binding]; other site 111781012524 sulfate 1 binding site; other site 111781012525 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 111781012526 active site 111781012527 hydrophilic channel; other site 111781012528 dimerization interface [polypeptide binding]; other site 111781012529 catalytic residues [active] 111781012530 active site lid [active] 111781012531 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 111781012532 homoserine kinase; Provisional; Region: PRK01212 111781012533 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 111781012534 2TM domain; Region: 2TM; pfam13239 111781012535 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 111781012536 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 111781012537 TPP-binding site; other site 111781012538 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 111781012539 PYR/PP interface [polypeptide binding]; other site 111781012540 dimer interface [polypeptide binding]; other site 111781012541 TPP binding site [chemical binding]; other site 111781012542 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 111781012543 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 111781012544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781012545 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781012546 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781012547 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 111781012548 DDE superfamily endonuclease; Region: DDE_4; cl17710 111781012549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 111781012550 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781012551 DDE superfamily endonuclease; Region: DDE_3; pfam13358 111781012552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 111781012553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781012554 Helix-turn-helix domain; Region: HTH_28; pfam13518 111781012555 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781012556 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 111781012557 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 111781012558 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 111781012559 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 111781012560 active site 111781012561 catalytic residues [active] 111781012562 DNA binding site [nucleotide binding] 111781012563 Int/Topo IB signature motif; other site 111781012564 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 111781012565 Predicted transcriptional regulators [Transcription]; Region: COG1695 111781012566 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 111781012567 AAA ATPase domain; Region: AAA_16; pfam13191 111781012568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 111781012569 non-specific DNA binding site [nucleotide binding]; other site 111781012570 salt bridge; other site 111781012571 sequence-specific DNA binding site [nucleotide binding]; other site 111781012572 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 111781012573 AAA domain; Region: AAA_30; pfam13604 111781012574 Family description; Region: UvrD_C_2; pfam13538 111781012575 Domain of unknown function DUF21; Region: DUF21; pfam01595 111781012576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 111781012577 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 111781012578 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 111781012579 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 111781012580 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 111781012581 Zn binding site [ion binding]; other site 111781012582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781012583 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781012584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 111781012585 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 111781012586 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 111781012587 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 111781012588 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 111781012589 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 111781012590 catalytic residues [active] 111781012591 dimer interface [polypeptide binding]; other site 111781012592 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 111781012593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 111781012594 NAD(P) binding site [chemical binding]; other site 111781012595 active site 111781012596 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 111781012597 catalytic triad [active] 111781012598 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 111781012599 Low molecular weight phosphatase family; Region: LMWPc; cd00115 111781012600 active site 111781012601 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 111781012602 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 111781012603 Cytochrome P450; Region: p450; cl12078 111781012604 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 111781012605 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 111781012606 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 111781012607 catalytic site [active] 111781012608 subunit interface [polypeptide binding]; other site 111781012609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781012610 TPR motif; other site 111781012611 binding surface 111781012612 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781012613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781012614 TPR motif; other site 111781012615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 111781012616 binding surface 111781012617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 111781012618 haemagglutination activity domain; Region: Haemagg_act; pfam05860 111781012619 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 111781012620 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 111781012621 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 111781012622 CHASE2 domain; Region: CHASE2; pfam05226 111781012623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781012624 dimer interface [polypeptide binding]; other site 111781012625 phosphorylation site [posttranslational modification] 111781012626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781012627 ATP binding site [chemical binding]; other site 111781012628 Mg2+ binding site [ion binding]; other site 111781012629 G-X-G motif; other site 111781012630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 111781012631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781012632 active site 111781012633 phosphorylation site [posttranslational modification] 111781012634 intermolecular recognition site; other site 111781012635 dimerization interface [polypeptide binding]; other site 111781012636 Response regulator receiver domain; Region: Response_reg; pfam00072 111781012637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781012638 active site 111781012639 phosphorylation site [posttranslational modification] 111781012640 intermolecular recognition site; other site 111781012641 dimerization interface [polypeptide binding]; other site 111781012642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781012643 ATP binding site [chemical binding]; other site 111781012644 Mg2+ binding site [ion binding]; other site 111781012645 G-X-G motif; other site 111781012646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 111781012647 binding surface 111781012648 TPR motif; other site 111781012649 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 111781012650 RNA polymerase sigma factor; Provisional; Region: PRK12519 111781012651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 111781012652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 111781012653 DNA binding residues [nucleotide binding] 111781012654 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 111781012655 Staphylococcal nuclease homologues; Region: SNc; smart00318 111781012656 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 111781012657 Catalytic site; other site 111781012658 Response regulator receiver domain; Region: Response_reg; pfam00072 111781012659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 111781012660 active site 111781012661 phosphorylation site [posttranslational modification] 111781012662 intermolecular recognition site; other site 111781012663 dimerization interface [polypeptide binding]; other site 111781012664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 111781012665 dimer interface [polypeptide binding]; other site 111781012666 phosphorylation site [posttranslational modification] 111781012667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 111781012668 ATP binding site [chemical binding]; other site 111781012669 Mg2+ binding site [ion binding]; other site 111781012670 G-X-G motif; other site 111781012671 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 111781012672 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 111781012673 active site 111781012674 PHP domain; Region: PHP; pfam02811 111781012675 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 111781012676 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 111781012677 ResB-like family; Region: ResB; pfam05140 111781012678 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 111781012679 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 111781012680 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 111781012681 homotrimer interaction site [polypeptide binding]; other site 111781012682 putative active site [active] 111781012683 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 111781012684 classical (c) SDRs; Region: SDR_c; cd05233 111781012685 NAD(P) binding site [chemical binding]; other site 111781012686 active site 111781012687 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 111781012688 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 111781012689 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 111781012690 active site 111781012691 HIGH motif; other site 111781012692 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 111781012693 KMSKS motif; other site 111781012694 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 111781012695 tRNA binding surface [nucleotide binding]; other site 111781012696 anticodon binding site; other site 111781012697 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655