-- dump date 20140619_131031 -- class Genbank::misc_feature -- table misc_feature_note -- id note 456481000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 456481000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 456481000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481000004 Walker A motif; other site 456481000005 ATP binding site [chemical binding]; other site 456481000006 Walker B motif; other site 456481000007 arginine finger; other site 456481000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 456481000009 DnaA box-binding interface [nucleotide binding]; other site 456481000010 DNA polymerase III subunit beta; Provisional; Region: PRK14942 456481000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 456481000012 putative DNA binding surface [nucleotide binding]; other site 456481000013 dimer interface [polypeptide binding]; other site 456481000014 beta-clamp/clamp loader binding surface; other site 456481000015 beta-clamp/translesion DNA polymerase binding surface; other site 456481000016 recombination protein F; Reviewed; Region: recF; PRK00064 456481000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481000018 Walker A/P-loop; other site 456481000019 ATP binding site [chemical binding]; other site 456481000020 Q-loop/lid; other site 456481000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481000022 ABC transporter signature motif; other site 456481000023 Walker B; other site 456481000024 D-loop; other site 456481000025 H-loop/switch region; other site 456481000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 456481000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 456481000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481000029 Mg2+ binding site [ion binding]; other site 456481000030 G-X-G motif; other site 456481000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 456481000032 anchoring element; other site 456481000033 dimer interface [polypeptide binding]; other site 456481000034 ATP binding site [chemical binding]; other site 456481000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 456481000036 active site 456481000037 putative metal-binding site [ion binding]; other site 456481000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 456481000039 DNA gyrase subunit A; Validated; Region: PRK05560 456481000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 456481000041 CAP-like domain; other site 456481000042 active site 456481000043 primary dimer interface [polypeptide binding]; other site 456481000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 456481000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 456481000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 456481000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 456481000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 456481000049 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 456481000050 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 456481000051 FMN binding site [chemical binding]; other site 456481000052 active site 456481000053 catalytic residues [active] 456481000054 substrate binding site [chemical binding]; other site 456481000055 PilZ domain; Region: PilZ; pfam07238 456481000056 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 456481000057 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 456481000058 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 456481000059 Maf-like protein; Reviewed; Region: PRK00078 456481000060 active site 456481000061 dimer interface [polypeptide binding]; other site 456481000062 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 456481000063 classical (c) SDRs; Region: SDR_c; cd05233 456481000064 NAD(P) binding site [chemical binding]; other site 456481000065 active site 456481000066 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 456481000067 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 456481000068 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 456481000069 putative active site [active] 456481000070 putative metal binding site [ion binding]; other site 456481000071 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 456481000072 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 456481000073 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 456481000074 ribonuclease R; Region: RNase_R; TIGR02063 456481000075 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481000076 RNB domain; Region: RNB; pfam00773 456481000077 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481000078 RNA binding site [nucleotide binding]; other site 456481000079 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 456481000080 Glycoprotease family; Region: Peptidase_M22; pfam00814 456481000081 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 456481000082 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 456481000083 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 456481000084 dimerization interface [polypeptide binding]; other site 456481000085 domain crossover interface; other site 456481000086 redox-dependent activation switch; other site 456481000087 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 456481000088 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 456481000089 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 456481000090 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 456481000091 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 456481000092 active site 456481000093 dimerization interface [polypeptide binding]; other site 456481000094 superoxide dismutase; Provisional; Region: PRK10543 456481000095 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 456481000096 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 456481000097 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 456481000098 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 456481000099 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 456481000100 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 456481000101 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 456481000102 glutamine binding [chemical binding]; other site 456481000103 catalytic triad [active] 456481000104 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481000105 Short C-terminal domain; Region: SHOCT; pfam09851 456481000106 serine O-acetyltransferase; Region: cysE; TIGR01172 456481000107 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 456481000108 trimer interface [polypeptide binding]; other site 456481000109 active site 456481000110 substrate binding site [chemical binding]; other site 456481000111 CoA binding site [chemical binding]; other site 456481000112 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 456481000113 Peptidase family M50; Region: Peptidase_M50; pfam02163 456481000114 active site 456481000115 putative substrate binding region [chemical binding]; other site 456481000116 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 456481000117 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 456481000118 inhibitor-cofactor binding pocket; inhibition site 456481000119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481000120 catalytic residue [active] 456481000121 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 456481000122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 456481000123 active site 456481000124 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 456481000125 dimer interface [polypeptide binding]; other site 456481000126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481000127 Coenzyme A binding pocket [chemical binding]; other site 456481000128 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 456481000129 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 456481000130 putative active site [active] 456481000131 metal binding site [ion binding]; metal-binding site 456481000132 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 456481000133 putative hydrolase; Provisional; Region: PRK11460 456481000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481000135 S-adenosylmethionine binding site [chemical binding]; other site 456481000136 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 456481000137 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 456481000138 Helix-turn-helix domain; Region: HTH_38; pfam13936 456481000139 Integrase core domain; Region: rve; pfam00665 456481000140 adenylosuccinate lyase; Provisional; Region: PRK07492 456481000141 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 456481000142 tetramer interface [polypeptide binding]; other site 456481000143 active site 456481000144 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 456481000145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 456481000146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481000147 NAD(P) binding site [chemical binding]; other site 456481000148 active site 456481000149 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481000150 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481000151 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 456481000152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481000153 substrate binding site [chemical binding]; other site 456481000154 oxyanion hole (OAH) forming residues; other site 456481000155 trimer interface [polypeptide binding]; other site 456481000156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481000157 active site 456481000158 phosphorylation site [posttranslational modification] 456481000159 intermolecular recognition site; other site 456481000160 dimerization interface [polypeptide binding]; other site 456481000161 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 456481000162 hypothetical protein; Validated; Region: PRK00110 456481000163 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481000164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481000165 active site 456481000166 Glutamine amidotransferase class-I; Region: GATase; pfam00117 456481000167 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 456481000168 glutamine binding [chemical binding]; other site 456481000169 catalytic triad [active] 456481000170 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 456481000171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481000172 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 456481000173 Walker A/P-loop; other site 456481000174 ATP binding site [chemical binding]; other site 456481000175 Q-loop/lid; other site 456481000176 ABC transporter signature motif; other site 456481000177 Walker B; other site 456481000178 D-loop; other site 456481000179 H-loop/switch region; other site 456481000180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 456481000181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481000182 active site 456481000183 phosphorylation site [posttranslational modification] 456481000184 intermolecular recognition site; other site 456481000185 HEAT repeats; Region: HEAT_2; pfam13646 456481000186 HEAT repeats; Region: HEAT_2; pfam13646 456481000187 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 456481000188 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 456481000189 HflX GTPase family; Region: HflX; cd01878 456481000190 G1 box; other site 456481000191 GTP/Mg2+ binding site [chemical binding]; other site 456481000192 Switch I region; other site 456481000193 G2 box; other site 456481000194 G3 box; other site 456481000195 Switch II region; other site 456481000196 G4 box; other site 456481000197 G5 box; other site 456481000198 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481000199 anti sigma factor interaction site; other site 456481000200 regulatory phosphorylation site [posttranslational modification]; other site 456481000201 homoserine dehydrogenase; Provisional; Region: PRK06349 456481000202 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 456481000203 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 456481000204 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 456481000205 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 456481000206 Uncharacterized conserved protein [Function unknown]; Region: COG1262 456481000207 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 456481000208 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 456481000209 MarR family; Region: MarR; pfam01047 456481000210 MarR family; Region: MarR_2; cl17246 456481000211 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 456481000212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481000213 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 456481000214 Uncharacterized conserved protein [Function unknown]; Region: COG5316 456481000215 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 456481000216 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481000217 anti sigma factor interaction site; other site 456481000218 regulatory phosphorylation site [posttranslational modification]; other site 456481000219 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 456481000220 galactokinase; Provisional; Region: PRK03817 456481000221 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 456481000222 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 456481000223 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 456481000224 active site 456481000225 dimer interface [polypeptide binding]; other site 456481000226 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 456481000227 dimer interface [polypeptide binding]; other site 456481000228 active site 456481000229 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 456481000230 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 456481000231 Substrate binding site; other site 456481000232 metal-binding site 456481000233 Phosphotransferase enzyme family; Region: APH; pfam01636 456481000234 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 456481000235 substrate binding site [chemical binding]; other site 456481000236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481000237 active site 456481000238 phosphorylation site [posttranslational modification] 456481000239 intermolecular recognition site; other site 456481000240 dimerization interface [polypeptide binding]; other site 456481000241 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 456481000242 PAS domain; Region: PAS; smart00091 456481000243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481000244 dimer interface [polypeptide binding]; other site 456481000245 phosphorylation site [posttranslational modification] 456481000246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481000247 ATP binding site [chemical binding]; other site 456481000248 G-X-G motif; other site 456481000249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 456481000250 putative active site [active] 456481000251 heme pocket [chemical binding]; other site 456481000252 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 456481000253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481000254 dimer interface [polypeptide binding]; other site 456481000255 phosphorylation site [posttranslational modification] 456481000256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481000257 ATP binding site [chemical binding]; other site 456481000258 Mg2+ binding site [ion binding]; other site 456481000259 G-X-G motif; other site 456481000260 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481000261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481000262 PGAP1-like protein; Region: PGAP1; pfam07819 456481000263 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 456481000264 Response regulator receiver domain; Region: Response_reg; pfam00072 456481000265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481000266 active site 456481000267 phosphorylation site [posttranslational modification] 456481000268 intermolecular recognition site; other site 456481000269 dimerization interface [polypeptide binding]; other site 456481000270 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 456481000271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 456481000272 RNA binding surface [nucleotide binding]; other site 456481000273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481000274 S-adenosylmethionine binding site [chemical binding]; other site 456481000275 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 456481000276 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 456481000277 substrate binding pocket [chemical binding]; other site 456481000278 chain length determination region; other site 456481000279 substrate-Mg2+ binding site; other site 456481000280 catalytic residues [active] 456481000281 aspartate-rich region 1; other site 456481000282 active site lid residues [active] 456481000283 aspartate-rich region 2; other site 456481000284 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 456481000285 active site 456481000286 multimer interface [polypeptide binding]; other site 456481000287 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 456481000288 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 456481000289 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 456481000290 Ligand Binding Site [chemical binding]; other site 456481000291 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 456481000292 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 456481000293 active site 456481000294 (T/H)XGH motif; other site 456481000295 argininosuccinate synthase; Provisional; Region: PRK13820 456481000296 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 456481000297 ANP binding site [chemical binding]; other site 456481000298 Substrate Binding Site II [chemical binding]; other site 456481000299 Substrate Binding Site I [chemical binding]; other site 456481000300 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 456481000301 active site 456481000302 catalytic triad [active] 456481000303 Predicted amidohydrolase [General function prediction only]; Region: COG0388 456481000304 dimer interface [polypeptide binding]; other site 456481000305 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 456481000306 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 456481000307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481000308 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 456481000309 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 456481000310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481000311 S-adenosylmethionine binding site [chemical binding]; other site 456481000312 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 456481000313 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 456481000314 quinone interaction residues [chemical binding]; other site 456481000315 active site 456481000316 catalytic residues [active] 456481000317 FMN binding site [chemical binding]; other site 456481000318 substrate binding site [chemical binding]; other site 456481000319 PAS fold; Region: PAS_4; pfam08448 456481000320 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 456481000321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481000322 putative active site [active] 456481000323 heme pocket [chemical binding]; other site 456481000324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481000325 dimer interface [polypeptide binding]; other site 456481000326 phosphorylation site [posttranslational modification] 456481000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481000328 ATP binding site [chemical binding]; other site 456481000329 Mg2+ binding site [ion binding]; other site 456481000330 G-X-G motif; other site 456481000331 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481000332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481000333 active site 456481000334 phosphorylation site [posttranslational modification] 456481000335 intermolecular recognition site; other site 456481000336 dimerization interface [polypeptide binding]; other site 456481000337 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481000338 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 456481000339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481000340 motif II; other site 456481000341 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 456481000342 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 456481000343 active site 456481000344 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481000345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481000346 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481000347 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 456481000348 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481000349 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481000350 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481000351 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481000352 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 456481000353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481000354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481000355 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 456481000356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481000357 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 456481000358 bile acid transporter; Region: bass; TIGR00841 456481000359 Sodium Bile acid symporter family; Region: SBF; pfam01758 456481000360 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481000361 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481000362 active site 456481000363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481000364 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 456481000365 NAD(P) binding site [chemical binding]; other site 456481000366 active site 456481000367 short chain dehydrogenase; Provisional; Region: PRK06179 456481000368 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 456481000369 NADP binding site [chemical binding]; other site 456481000370 active site 456481000371 steroid binding site; other site 456481000372 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 456481000373 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 456481000374 acyl-activating enzyme (AAE) consensus motif; other site 456481000375 putative AMP binding site [chemical binding]; other site 456481000376 putative active site [active] 456481000377 putative CoA binding site [chemical binding]; other site 456481000378 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481000379 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 456481000380 substrate binding site [chemical binding]; other site 456481000381 oxyanion hole (OAH) forming residues; other site 456481000382 trimer interface [polypeptide binding]; other site 456481000383 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481000384 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481000385 dimer interface [polypeptide binding]; other site 456481000386 putative CheW interface [polypeptide binding]; other site 456481000387 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 456481000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481000389 putative substrate translocation pore; other site 456481000390 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 456481000391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 456481000392 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 456481000393 putative NAD(P) binding site [chemical binding]; other site 456481000394 active site 456481000395 putative substrate binding site [chemical binding]; other site 456481000396 bile acid transporter; Region: bass; TIGR00841 456481000397 Sodium Bile acid symporter family; Region: SBF; cl17470 456481000398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481000399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481000400 dimer interface [polypeptide binding]; other site 456481000401 putative CheW interface [polypeptide binding]; other site 456481000402 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481000403 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481000404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481000405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481000406 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 456481000407 RibD C-terminal domain; Region: RibD_C; cl17279 456481000408 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 456481000409 Predicted membrane protein [Function unknown]; Region: COG4682 456481000410 yiaA/B two helix domain; Region: YiaAB; pfam05360 456481000411 yiaA/B two helix domain; Region: YiaAB; pfam05360 456481000412 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 456481000413 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 456481000414 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 456481000415 classical (c) SDRs; Region: SDR_c; cd05233 456481000416 NAD(P) binding site [chemical binding]; other site 456481000417 active site 456481000418 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 456481000419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481000420 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481000421 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 456481000422 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 456481000423 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 456481000424 PAS domain S-box; Region: sensory_box; TIGR00229 456481000425 PAS fold; Region: PAS_4; pfam08448 456481000426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481000427 putative active site [active] 456481000428 heme pocket [chemical binding]; other site 456481000429 PAS domain S-box; Region: sensory_box; TIGR00229 456481000430 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 456481000431 amphipathic channel; other site 456481000432 Asn-Pro-Ala signature motifs; other site 456481000433 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 456481000434 Malic enzyme, N-terminal domain; Region: malic; pfam00390 456481000435 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 456481000436 putative NAD(P) binding site [chemical binding]; other site 456481000437 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 456481000438 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 456481000439 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 456481000440 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 456481000441 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 456481000442 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 456481000443 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 456481000444 cobalamin binding residues [chemical binding]; other site 456481000445 putative BtuC binding residues; other site 456481000446 dimer interface [polypeptide binding]; other site 456481000447 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 456481000448 TrkA-N domain; Region: TrkA_N; pfam02254 456481000449 TrkA-C domain; Region: TrkA_C; pfam02080 456481000450 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 456481000451 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 456481000452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 456481000453 active site 456481000454 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 456481000455 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 456481000456 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481000457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481000458 ligand binding site [chemical binding]; other site 456481000459 flexible hinge region; other site 456481000460 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 456481000461 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 456481000462 nucleophile elbow; other site 456481000463 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 456481000464 Short C-terminal domain; Region: SHOCT; pfam09851 456481000465 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 456481000466 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 456481000467 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 456481000468 Sulfatase; Region: Sulfatase; cl17466 456481000469 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 456481000470 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 456481000471 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 456481000472 NADP-binding site; other site 456481000473 homotetramer interface [polypeptide binding]; other site 456481000474 substrate binding site [chemical binding]; other site 456481000475 homodimer interface [polypeptide binding]; other site 456481000476 active site 456481000477 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481000478 anti sigma factor interaction site; other site 456481000479 regulatory phosphorylation site [posttranslational modification]; other site 456481000480 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481000481 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 456481000482 ligand binding site [chemical binding]; other site 456481000483 flexible hinge region; other site 456481000484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481000485 ligand binding site [chemical binding]; other site 456481000486 flexible hinge region; other site 456481000487 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 456481000488 von Willebrand factor type A domain; Region: VWA_2; pfam13519 456481000489 metal ion-dependent adhesion site (MIDAS); other site 456481000490 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 456481000491 putative active site [active] 456481000492 putative CoA binding site [chemical binding]; other site 456481000493 nudix motif; other site 456481000494 metal binding site [ion binding]; metal-binding site 456481000495 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 456481000496 catalytic site [active] 456481000497 putative active site [active] 456481000498 putative substrate binding site [chemical binding]; other site 456481000499 HRDC domain; Region: HRDC; pfam00570 456481000500 amidophosphoribosyltransferase; Provisional; Region: PRK09123 456481000501 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 456481000502 active site 456481000503 tetramer interface [polypeptide binding]; other site 456481000504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 456481000505 active site 456481000506 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 456481000507 active site 456481000508 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 456481000509 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 456481000510 Ligand Binding Site [chemical binding]; other site 456481000511 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 456481000512 active site 456481000513 catalytic triad [active] 456481000514 oxyanion hole [active] 456481000515 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481000516 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481000517 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 456481000518 PA/protease or protease-like domain interface [polypeptide binding]; other site 456481000519 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 456481000520 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 456481000521 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 456481000522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 456481000523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481000524 active site 456481000525 phosphorylation site [posttranslational modification] 456481000526 intermolecular recognition site; other site 456481000527 dimerization interface [polypeptide binding]; other site 456481000528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 456481000529 DNA binding residues [nucleotide binding] 456481000530 dimerization interface [polypeptide binding]; other site 456481000531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481000532 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481000533 binding surface 456481000534 TPR motif; other site 456481000535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481000536 binding surface 456481000537 TPR motif; other site 456481000538 TPR repeat; Region: TPR_11; pfam13414 456481000539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481000540 active site 456481000541 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 456481000542 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481000543 FeS/SAM binding site; other site 456481000544 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 456481000545 SurA N-terminal domain; Region: SurA_N_3; cl07813 456481000546 putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142 456481000547 aspartate kinase; Reviewed; Region: PRK06635 456481000548 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 456481000549 putative nucleotide binding site [chemical binding]; other site 456481000550 putative catalytic residues [active] 456481000551 putative Mg ion binding site [ion binding]; other site 456481000552 putative aspartate binding site [chemical binding]; other site 456481000553 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 456481000554 putative allosteric regulatory site; other site 456481000555 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 456481000556 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 456481000557 Fatty acid desaturase; Region: FA_desaturase; pfam00487 456481000558 Di-iron ligands [ion binding]; other site 456481000559 Late embryogenesis abundant protein; Region: LEA_2; cl12118 456481000560 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 456481000561 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 456481000562 NADP binding site [chemical binding]; other site 456481000563 dimer interface [polypeptide binding]; other site 456481000564 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 456481000565 mce related protein; Region: MCE; pfam02470 456481000566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481000567 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 456481000568 putative ADP-binding pocket [chemical binding]; other site 456481000569 Flagellar protein (FlbD); Region: FlbD; pfam06289 456481000570 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 456481000571 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 456481000572 flagellar motor protein MotB; Validated; Region: motB; PRK06667 456481000573 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 456481000574 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481000575 ligand binding site [chemical binding]; other site 456481000576 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 456481000577 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 456481000578 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 456481000579 Ligand binding site; other site 456481000580 oligomer interface; other site 456481000581 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 456481000582 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 456481000583 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 456481000584 TrkA-N domain; Region: TrkA_N; pfam02254 456481000585 Outer membrane efflux protein; Region: OEP; pfam02321 456481000586 Outer membrane efflux protein; Region: OEP; pfam02321 456481000587 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 456481000588 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 456481000589 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481000590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481000591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481000592 Walker A/P-loop; other site 456481000593 ATP binding site [chemical binding]; other site 456481000594 ABC transporter; Region: ABC_tran; pfam00005 456481000595 Q-loop/lid; other site 456481000596 ABC transporter signature motif; other site 456481000597 Walker B; other site 456481000598 D-loop; other site 456481000599 H-loop/switch region; other site 456481000600 YceI-like domain; Region: YceI; cl01001 456481000601 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 456481000602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481000603 Coenzyme A binding pocket [chemical binding]; other site 456481000604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481000605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481000606 tropinone reductase; Provisional; Region: PRK09242 456481000607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481000608 NAD(P) binding site [chemical binding]; other site 456481000609 active site 456481000610 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 456481000611 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 456481000612 putative hydrophobic ligand binding site [chemical binding]; other site 456481000613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481000614 dimerization interface [polypeptide binding]; other site 456481000615 putative DNA binding site [nucleotide binding]; other site 456481000616 putative Zn2+ binding site [ion binding]; other site 456481000617 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 456481000618 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 456481000619 nucleotide binding pocket [chemical binding]; other site 456481000620 K-X-D-G motif; other site 456481000621 catalytic site [active] 456481000622 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 456481000623 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 456481000624 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 456481000625 Dimer interface [polypeptide binding]; other site 456481000626 BRCT sequence motif; other site 456481000627 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481000628 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481000629 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 456481000630 putative active site [active] 456481000631 YceI-like domain; Region: YceI; smart00867 456481000632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481000633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481000634 active site 456481000635 Membrane transport protein; Region: Mem_trans; cl09117 456481000636 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 456481000637 EamA-like transporter family; Region: EamA; pfam00892 456481000638 EamA-like transporter family; Region: EamA; pfam00892 456481000639 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 456481000640 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 456481000641 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 456481000642 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 456481000643 putative acyl-acceptor binding pocket; other site 456481000644 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 456481000645 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 456481000646 transmembrane helices; other site 456481000647 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 456481000648 EVE domain; Region: EVE; cl00728 456481000649 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 456481000650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481000651 Walker A motif; other site 456481000652 ATP binding site [chemical binding]; other site 456481000653 Walker B motif; other site 456481000654 arginine finger; other site 456481000655 Peptidase family M41; Region: Peptidase_M41; pfam01434 456481000656 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 456481000657 putative active site [active] 456481000658 catalytic residue [active] 456481000659 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 456481000660 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 456481000661 5S rRNA interface [nucleotide binding]; other site 456481000662 CTC domain interface [polypeptide binding]; other site 456481000663 L16 interface [polypeptide binding]; other site 456481000664 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 456481000665 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 456481000666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 456481000667 active site 456481000668 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 456481000669 Substrate binding site; other site 456481000670 Mg++ binding site; other site 456481000671 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14613 456481000672 WYL domain; Region: WYL; pfam13280 456481000673 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 456481000674 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 456481000675 putative transporter; Provisional; Region: PRK10484 456481000676 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 456481000677 Na binding site [ion binding]; other site 456481000678 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481000679 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481000680 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 456481000681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481000682 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 456481000683 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 456481000684 putative active site [active] 456481000685 putative metal binding site [ion binding]; other site 456481000686 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 456481000687 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 456481000688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481000689 active site 456481000690 HIGH motif; other site 456481000691 nucleotide binding site [chemical binding]; other site 456481000692 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 456481000693 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 456481000694 active site 456481000695 KMSKS motif; other site 456481000696 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 456481000697 tRNA binding surface [nucleotide binding]; other site 456481000698 anticodon binding site; other site 456481000699 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 456481000700 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13789 456481000701 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 456481000702 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 456481000703 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 456481000704 peptide chain release factor 2; Validated; Region: prfB; PRK00578 456481000705 PCRF domain; Region: PCRF; pfam03462 456481000706 RF-1 domain; Region: RF-1; pfam00472 456481000707 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 456481000708 GAF domain; Region: GAF; pfam01590 456481000709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481000710 Walker A motif; other site 456481000711 ATP binding site [chemical binding]; other site 456481000712 Walker B motif; other site 456481000713 arginine finger; other site 456481000714 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 456481000715 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481000716 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481000717 ligand binding site [chemical binding]; other site 456481000718 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 456481000719 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 456481000720 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 456481000721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 456481000722 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 456481000723 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 456481000724 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 456481000725 Catalytic site [active] 456481000726 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 456481000727 threonine synthase; Validated; Region: PRK06260 456481000728 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 456481000729 homodimer interface [polypeptide binding]; other site 456481000730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481000731 catalytic residue [active] 456481000732 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481000733 active site 456481000734 HIGH motif; other site 456481000735 nucleotide binding site [chemical binding]; other site 456481000736 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481000737 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 456481000738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481000739 active site 456481000740 KMSKS motif; other site 456481000741 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 456481000742 tRNA binding surface [nucleotide binding]; other site 456481000743 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 456481000744 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481000745 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481000746 Walker A/P-loop; other site 456481000747 ATP binding site [chemical binding]; other site 456481000748 Q-loop/lid; other site 456481000749 ABC transporter signature motif; other site 456481000750 Walker B; other site 456481000751 D-loop; other site 456481000752 H-loop/switch region; other site 456481000753 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 456481000754 FtsX-like permease family; Region: FtsX; pfam02687 456481000755 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 456481000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481000757 Walker A motif; other site 456481000758 ATP binding site [chemical binding]; other site 456481000759 Walker B motif; other site 456481000760 arginine finger; other site 456481000761 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 456481000762 catalytic center binding site [active] 456481000763 ATP binding site [chemical binding]; other site 456481000764 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 456481000765 oligomerization interface [polypeptide binding]; other site 456481000766 active site 456481000767 metal binding site [ion binding]; metal-binding site 456481000768 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 456481000769 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 456481000770 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 456481000771 active site residue [active] 456481000772 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 456481000773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481000774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481000775 ABC transporter; Region: ABC_tran_2; pfam12848 456481000776 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481000777 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 456481000778 Predicted permeases [General function prediction only]; Region: COG0730 456481000779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481000780 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 456481000781 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 456481000782 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 456481000783 catalytic residues [active] 456481000784 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 456481000785 Protein export membrane protein; Region: SecD_SecF; cl14618 456481000786 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 456481000787 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 456481000788 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 456481000789 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481000790 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481000791 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 456481000792 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 456481000793 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 456481000794 GTP/Mg2+ binding site [chemical binding]; other site 456481000795 G4 box; other site 456481000796 G5 box; other site 456481000797 trmE is a tRNA modification GTPase; Region: trmE; cd04164 456481000798 G1 box; other site 456481000799 G1 box; other site 456481000800 GTP/Mg2+ binding site [chemical binding]; other site 456481000801 Switch I region; other site 456481000802 Switch I region; other site 456481000803 G2 box; other site 456481000804 G2 box; other site 456481000805 Switch II region; other site 456481000806 G3 box; other site 456481000807 G3 box; other site 456481000808 Switch II region; other site 456481000809 G4 box; other site 456481000810 G5 box; other site 456481000811 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 456481000812 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 456481000813 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 456481000814 G-X-X-G motif; other site 456481000815 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 456481000816 RxxxH motif; other site 456481000817 membrane protein insertase; Provisional; Region: PRK01318 456481000818 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 456481000819 Haemolytic domain; Region: Haemolytic; pfam01809 456481000820 MltA specific insert domain; Region: MltA; cl08398 456481000821 3D domain; Region: 3D; pfam06725 456481000822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481000823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481000824 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 456481000825 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 456481000826 putative C-terminal domain interface [polypeptide binding]; other site 456481000827 putative GSH binding site (G-site) [chemical binding]; other site 456481000828 putative dimer interface [polypeptide binding]; other site 456481000829 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 456481000830 N-terminal domain interface [polypeptide binding]; other site 456481000831 dimer interface [polypeptide binding]; other site 456481000832 substrate binding pocket (H-site) [chemical binding]; other site 456481000833 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 456481000834 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 456481000835 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481000836 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481000837 metal binding site [ion binding]; metal-binding site 456481000838 active site 456481000839 I-site; other site 456481000840 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481000841 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 456481000842 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 456481000843 Methyltransferase domain; Region: Methyltransf_31; pfam13847 456481000844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481000845 S-adenosylmethionine binding site [chemical binding]; other site 456481000846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481000847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481000848 putative substrate translocation pore; other site 456481000849 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 456481000850 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 456481000851 trimer interface [polypeptide binding]; other site 456481000852 putative metal binding site [ion binding]; other site 456481000853 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481000854 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481000855 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481000856 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 456481000857 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 456481000858 putative tRNA-binding site [nucleotide binding]; other site 456481000859 B3/4 domain; Region: B3_4; pfam03483 456481000860 tRNA synthetase B5 domain; Region: B5; smart00874 456481000861 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 456481000862 dimer interface [polypeptide binding]; other site 456481000863 motif 1; other site 456481000864 motif 3; other site 456481000865 motif 2; other site 456481000866 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 456481000867 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481000868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481000869 putative active site [active] 456481000870 heme pocket [chemical binding]; other site 456481000871 PAS domain; Region: PAS; smart00091 456481000872 putative active site [active] 456481000873 heme pocket [chemical binding]; other site 456481000874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481000875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481000876 metal binding site [ion binding]; metal-binding site 456481000877 active site 456481000878 I-site; other site 456481000879 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481000880 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 456481000881 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 456481000882 active site 456481000883 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 456481000884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481000885 ATP binding site [chemical binding]; other site 456481000886 putative Mg++ binding site [ion binding]; other site 456481000887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481000888 nucleotide binding region [chemical binding]; other site 456481000889 ATP-binding site [chemical binding]; other site 456481000890 RQC domain; Region: RQC; pfam09382 456481000891 HRDC domain; Region: HRDC; pfam00570 456481000892 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481000893 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481000894 Caspase domain; Region: Peptidase_C14; pfam00656 456481000895 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 456481000896 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 456481000897 cell division protein FtsA; Region: ftsA; TIGR01174 456481000898 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 456481000899 nucleotide binding site [chemical binding]; other site 456481000900 Cell division protein FtsA; Region: FtsA; pfam14450 456481000901 cell division protein FtsZ; Validated; Region: PRK09330 456481000902 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 456481000903 nucleotide binding site [chemical binding]; other site 456481000904 SulA interaction site; other site 456481000905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 456481000906 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 456481000907 quinolinate synthetase; Provisional; Region: PRK09375 456481000908 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 456481000909 homotrimer interaction site [polypeptide binding]; other site 456481000910 zinc binding site [ion binding]; other site 456481000911 CDP-binding sites; other site 456481000912 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481000913 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481000914 TPR repeat; Region: TPR_11; pfam13414 456481000915 TPR repeat; Region: TPR_11; pfam13414 456481000916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481000917 binding surface 456481000918 TPR motif; other site 456481000919 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 456481000920 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 456481000921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481000922 ABC-ATPase subunit interface; other site 456481000923 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 456481000924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481000925 dimer interface [polypeptide binding]; other site 456481000926 conserved gate region; other site 456481000927 putative PBP binding loops; other site 456481000928 ABC-ATPase subunit interface; other site 456481000929 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 456481000930 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 456481000931 Walker A/P-loop; other site 456481000932 ATP binding site [chemical binding]; other site 456481000933 Q-loop/lid; other site 456481000934 ABC transporter signature motif; other site 456481000935 Walker B; other site 456481000936 D-loop; other site 456481000937 H-loop/switch region; other site 456481000938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 456481000939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 456481000940 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 456481000941 Walker A/P-loop; other site 456481000942 ATP binding site [chemical binding]; other site 456481000943 Q-loop/lid; other site 456481000944 ABC transporter signature motif; other site 456481000945 Walker B; other site 456481000946 D-loop; other site 456481000947 H-loop/switch region; other site 456481000948 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 456481000949 AsmA family; Region: AsmA; pfam05170 456481000950 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 456481000951 HEAT repeats; Region: HEAT_2; pfam13646 456481000952 Bacterial SH3 domain; Region: SH3_3; pfam08239 456481000953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481000954 Walker A/P-loop; other site 456481000955 ATP binding site [chemical binding]; other site 456481000956 Q-loop/lid; other site 456481000957 ABC transporter signature motif; other site 456481000958 Walker B; other site 456481000959 D-loop; other site 456481000960 H-loop/switch region; other site 456481000961 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481000962 acyl-activating enzyme (AAE) consensus motif; other site 456481000963 CoA binding site [chemical binding]; other site 456481000964 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481000965 AMP binding site [chemical binding]; other site 456481000966 active site 456481000967 CoA binding site [chemical binding]; other site 456481000968 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 456481000969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481000970 substrate binding site [chemical binding]; other site 456481000971 oxyanion hole (OAH) forming residues; other site 456481000972 trimer interface [polypeptide binding]; other site 456481000973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 456481000974 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 456481000975 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 456481000976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481000977 FeS/SAM binding site; other site 456481000978 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 456481000979 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 456481000980 active site 456481000981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481000982 MAPEG family; Region: MAPEG; pfam01124 456481000983 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 456481000984 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 456481000985 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 456481000986 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 456481000987 metal binding site [ion binding]; metal-binding site 456481000988 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 456481000989 active site 456481000990 metal binding site [ion binding]; metal-binding site 456481000991 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 456481000992 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 456481000993 generic binding surface II; other site 456481000994 ssDNA binding site; other site 456481000995 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481000996 ATP binding site [chemical binding]; other site 456481000997 putative Mg++ binding site [ion binding]; other site 456481000998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481000999 nucleotide binding region [chemical binding]; other site 456481001000 ATP-binding site [chemical binding]; other site 456481001001 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 456481001002 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 456481001003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481001004 NAD(P) binding site [chemical binding]; other site 456481001005 active site 456481001006 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 456481001007 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 456481001008 active site 456481001009 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 456481001010 putative binding surface; other site 456481001011 active site 456481001012 putative acyltransferase; Provisional; Region: PRK05790 456481001013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 456481001014 dimer interface [polypeptide binding]; other site 456481001015 active site 456481001016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481001017 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481001018 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481001019 ligand binding site [chemical binding]; other site 456481001020 flexible hinge region; other site 456481001021 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481001022 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481001023 ligand binding site [chemical binding]; other site 456481001024 flexible hinge region; other site 456481001025 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 456481001026 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 456481001027 putative active site [active] 456481001028 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481001029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481001030 Walker A/P-loop; other site 456481001031 ATP binding site [chemical binding]; other site 456481001032 Q-loop/lid; other site 456481001033 ABC transporter signature motif; other site 456481001034 Walker B; other site 456481001035 D-loop; other site 456481001036 H-loop/switch region; other site 456481001037 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 456481001038 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 456481001039 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481001040 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481001041 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481001042 ligand binding site [chemical binding]; other site 456481001043 flexible hinge region; other site 456481001044 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 456481001045 putative active site [active] 456481001046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481001047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 456481001048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481001049 Walker A/P-loop; other site 456481001050 ATP binding site [chemical binding]; other site 456481001051 Q-loop/lid; other site 456481001052 ABC transporter signature motif; other site 456481001053 Walker B; other site 456481001054 D-loop; other site 456481001055 H-loop/switch region; other site 456481001056 Outer membrane efflux protein; Region: OEP; pfam02321 456481001057 Predicted membrane protein [Function unknown]; Region: COG3463 456481001058 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 456481001059 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 456481001060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 456481001061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481001062 Coenzyme A binding pocket [chemical binding]; other site 456481001063 DinB family; Region: DinB; cl17821 456481001064 DinB superfamily; Region: DinB_2; pfam12867 456481001065 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 456481001066 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 456481001067 Chromate transporter; Region: Chromate_transp; pfam02417 456481001068 Predicted transcriptional regulators [Transcription]; Region: COG1695 456481001069 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 456481001070 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 456481001071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481001072 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 456481001073 Coenzyme A binding pocket [chemical binding]; other site 456481001074 Protein of unknown function (DUF461); Region: DUF461; cl01071 456481001075 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 456481001076 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 456481001077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 456481001078 Walker A/P-loop; other site 456481001079 ATP binding site [chemical binding]; other site 456481001080 Q-loop/lid; other site 456481001081 ABC transporter signature motif; other site 456481001082 Walker B; other site 456481001083 D-loop; other site 456481001084 H-loop/switch region; other site 456481001085 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 456481001086 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 456481001087 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 456481001088 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 456481001089 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 456481001090 Cytochrome c; Region: Cytochrom_C; pfam00034 456481001091 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 456481001092 Fasciclin domain; Region: Fasciclin; pfam02469 456481001093 Hemerythrin; Region: Hemerythrin; cd12107 456481001094 Fe binding site [ion binding]; other site 456481001095 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 456481001096 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 456481001097 putative protease; Provisional; Region: PRK15452 456481001098 Peptidase family U32; Region: Peptidase_U32; pfam01136 456481001099 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 456481001100 DNA-binding response regulator CreB; Provisional; Region: PRK11083 456481001101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481001102 active site 456481001103 phosphorylation site [posttranslational modification] 456481001104 intermolecular recognition site; other site 456481001105 dimerization interface [polypeptide binding]; other site 456481001106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 456481001107 DNA binding site [nucleotide binding] 456481001108 sensory histidine kinase CreC; Provisional; Region: PRK11100 456481001109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001110 dimer interface [polypeptide binding]; other site 456481001111 phosphorylation site [posttranslational modification] 456481001112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001113 ATP binding site [chemical binding]; other site 456481001114 Mg2+ binding site [ion binding]; other site 456481001115 G-X-G motif; other site 456481001116 inner membrane protein; Provisional; Region: PRK11715 456481001117 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 456481001118 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 456481001119 putative hydrophobic ligand binding site [chemical binding]; other site 456481001120 MASE1; Region: MASE1; pfam05231 456481001121 CHASE domain; Region: CHASE; pfam03924 456481001122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481001123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001124 dimer interface [polypeptide binding]; other site 456481001125 phosphorylation site [posttranslational modification] 456481001126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001127 ATP binding site [chemical binding]; other site 456481001128 Mg2+ binding site [ion binding]; other site 456481001129 G-X-G motif; other site 456481001130 Response regulator receiver domain; Region: Response_reg; pfam00072 456481001131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481001132 active site 456481001133 phosphorylation site [posttranslational modification] 456481001134 intermolecular recognition site; other site 456481001135 dimerization interface [polypeptide binding]; other site 456481001136 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 456481001137 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 456481001138 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 456481001139 RibD C-terminal domain; Region: RibD_C; cl17279 456481001140 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 456481001141 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 456481001142 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 456481001143 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 456481001144 substrate binding pocket [chemical binding]; other site 456481001145 Secretory lipase; Region: LIP; pfam03583 456481001146 hypothetical protein; Validated; Region: PRK00029 456481001147 Uncharacterized conserved protein [Function unknown]; Region: COG0397 456481001148 YhhN-like protein; Region: YhhN; pfam07947 456481001149 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 456481001150 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481001151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481001152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481001153 dimer interface [polypeptide binding]; other site 456481001154 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481001155 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481001156 dimer interface [polypeptide binding]; other site 456481001157 putative CheW interface [polypeptide binding]; other site 456481001158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481001159 PAS domain; Region: PAS_9; pfam13426 456481001160 putative active site [active] 456481001161 heme pocket [chemical binding]; other site 456481001162 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 456481001163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481001164 putative active site [active] 456481001165 heme pocket [chemical binding]; other site 456481001166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001167 dimer interface [polypeptide binding]; other site 456481001168 phosphorylation site [posttranslational modification] 456481001169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001170 ATP binding site [chemical binding]; other site 456481001171 Mg2+ binding site [ion binding]; other site 456481001172 G-X-G motif; other site 456481001173 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481001175 active site 456481001176 phosphorylation site [posttranslational modification] 456481001177 intermolecular recognition site; other site 456481001178 dimerization interface [polypeptide binding]; other site 456481001179 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 456481001180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481001181 dimerization interface [polypeptide binding]; other site 456481001182 putative DNA binding site [nucleotide binding]; other site 456481001183 putative Zn2+ binding site [ion binding]; other site 456481001184 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 456481001185 putative hydrophobic ligand binding site [chemical binding]; other site 456481001186 Putative transposase; Region: Y2_Tnp; pfam04986 456481001187 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 456481001188 putative active site [active] 456481001189 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 456481001190 Galactose oxidase, central domain; Region: Kelch_3; cl02701 456481001191 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 456481001192 Kelch domain; Region: Kelch; smart00612 456481001193 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 456481001194 Putative transposase; Region: Y2_Tnp; pfam04986 456481001195 rod shape-determining protein MreB; Provisional; Region: PRK13927 456481001196 MreB and similar proteins; Region: MreB_like; cd10225 456481001197 nucleotide binding site [chemical binding]; other site 456481001198 Mg binding site [ion binding]; other site 456481001199 putative protofilament interaction site [polypeptide binding]; other site 456481001200 RodZ interaction site [polypeptide binding]; other site 456481001201 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 456481001202 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 456481001203 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 456481001204 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481001205 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481001207 binding surface 456481001208 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481001209 TPR motif; other site 456481001210 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 456481001211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481001212 putative substrate translocation pore; other site 456481001213 multifunctional aminopeptidase A; Provisional; Region: PRK00913 456481001214 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 456481001215 interface (dimer of trimers) [polypeptide binding]; other site 456481001216 Substrate-binding/catalytic site; other site 456481001217 Zn-binding sites [ion binding]; other site 456481001218 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 456481001219 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 456481001220 catalytic triad [active] 456481001221 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 456481001222 TrkA-C domain; Region: TrkA_C; pfam02080 456481001223 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 456481001224 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 456481001225 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 456481001226 tandem repeat interface [polypeptide binding]; other site 456481001227 oligomer interface [polypeptide binding]; other site 456481001228 active site residues [active] 456481001229 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 456481001230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481001231 binding surface 456481001232 TPR motif; other site 456481001233 TPR repeat; Region: TPR_11; pfam13414 456481001234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481001235 binding surface 456481001236 TPR motif; other site 456481001237 TPR repeat; Region: TPR_11; pfam13414 456481001238 Src Homology 3 domain superfamily; Region: SH3; cl17036 456481001239 Bacterial SH3 domain homologues; Region: SH3b; smart00287 456481001240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481001241 dimerization interface [polypeptide binding]; other site 456481001242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481001243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481001244 dimer interface [polypeptide binding]; other site 456481001245 putative CheW interface [polypeptide binding]; other site 456481001246 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 456481001247 NMT1/THI5 like; Region: NMT1; pfam09084 456481001248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001249 dimer interface [polypeptide binding]; other site 456481001250 phosphorylation site [posttranslational modification] 456481001251 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 456481001252 Protein of unknown function (DUF805); Region: DUF805; pfam05656 456481001253 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 456481001254 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 456481001255 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 456481001256 active site 456481001257 DNA binding site [nucleotide binding] 456481001258 Int/Topo IB signature motif; other site 456481001259 L-aspartate oxidase; Provisional; Region: PRK09077 456481001260 L-aspartate oxidase; Provisional; Region: PRK06175 456481001261 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 456481001262 C-terminal peptidase (prc); Region: prc; TIGR00225 456481001263 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 456481001264 protein binding site [polypeptide binding]; other site 456481001265 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 456481001266 Catalytic dyad [active] 456481001267 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 456481001268 active site 456481001269 hydrophilic channel; other site 456481001270 dimerization interface [polypeptide binding]; other site 456481001271 catalytic residues [active] 456481001272 active site lid [active] 456481001273 TIGR02300 family protein; Region: FYDLN_acid 456481001274 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 456481001275 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 456481001276 bacterial Hfq-like; Region: Hfq; cd01716 456481001277 hexamer interface [polypeptide binding]; other site 456481001278 Sm1 motif; other site 456481001279 RNA binding site [nucleotide binding]; other site 456481001280 Sm2 motif; other site 456481001281 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 456481001282 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 456481001283 Substrate binding site; other site 456481001284 Cupin domain; Region: Cupin_2; cl17218 456481001285 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 456481001286 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 456481001287 PhoU domain; Region: PhoU; pfam01895 456481001288 PhoU domain; Region: PhoU; pfam01895 456481001289 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481001290 dimer interface [polypeptide binding]; other site 456481001291 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 456481001292 putative CheW interface [polypeptide binding]; other site 456481001293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 456481001294 dimerization interface [polypeptide binding]; other site 456481001295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001296 dimer interface [polypeptide binding]; other site 456481001297 phosphorylation site [posttranslational modification] 456481001298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001299 ATP binding site [chemical binding]; other site 456481001300 Mg2+ binding site [ion binding]; other site 456481001301 G-X-G motif; other site 456481001302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481001303 binding surface 456481001304 TPR motif; other site 456481001305 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 456481001306 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 456481001307 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 456481001308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 456481001309 HAMP domain; Region: HAMP; pfam00672 456481001310 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481001312 TPR motif; other site 456481001313 binding surface 456481001314 TPR repeat; Region: TPR_11; pfam13414 456481001315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481001316 binding surface 456481001317 TPR motif; other site 456481001318 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481001319 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481001320 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481001321 anti sigma factor interaction site; other site 456481001322 regulatory phosphorylation site [posttranslational modification]; other site 456481001323 Beta-lactamase; Region: Beta-lactamase; pfam00144 456481001324 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 456481001325 Beta-lactamase; Region: Beta-lactamase; pfam00144 456481001326 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 456481001327 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 456481001328 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 456481001329 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 456481001330 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 456481001331 N-terminal plug; other site 456481001332 ligand-binding site [chemical binding]; other site 456481001333 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 456481001334 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 456481001335 substrate binding site [chemical binding]; other site 456481001336 ATP binding site [chemical binding]; other site 456481001337 Response regulator receiver domain; Region: Response_reg; pfam00072 456481001338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481001339 active site 456481001340 phosphorylation site [posttranslational modification] 456481001341 intermolecular recognition site; other site 456481001342 dimerization interface [polypeptide binding]; other site 456481001343 PAS fold; Region: PAS_4; pfam08448 456481001344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481001345 putative active site [active] 456481001346 heme pocket [chemical binding]; other site 456481001347 PAS domain S-box; Region: sensory_box; TIGR00229 456481001348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481001349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001350 dimer interface [polypeptide binding]; other site 456481001351 phosphorylation site [posttranslational modification] 456481001352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001353 ATP binding site [chemical binding]; other site 456481001354 Mg2+ binding site [ion binding]; other site 456481001355 G-X-G motif; other site 456481001356 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 456481001357 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 456481001358 Walker A/P-loop; other site 456481001359 ATP binding site [chemical binding]; other site 456481001360 Q-loop/lid; other site 456481001361 ABC transporter signature motif; other site 456481001362 Walker B; other site 456481001363 D-loop; other site 456481001364 H-loop/switch region; other site 456481001365 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 456481001366 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 456481001367 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 456481001368 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 456481001369 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 456481001370 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 456481001371 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 456481001372 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 456481001373 dimer interface [polypeptide binding]; other site 456481001374 motif 1; other site 456481001375 active site 456481001376 motif 2; other site 456481001377 motif 3; other site 456481001378 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 456481001379 active site 456481001380 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 456481001381 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 456481001382 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 456481001383 active site 456481001384 substrate binding site [chemical binding]; other site 456481001385 metal binding site [ion binding]; metal-binding site 456481001386 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 456481001387 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 456481001388 glutaminase active site [active] 456481001389 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 456481001390 dimer interface [polypeptide binding]; other site 456481001391 active site 456481001392 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 456481001393 dimer interface [polypeptide binding]; other site 456481001394 active site 456481001395 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 456481001396 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 456481001397 putative trimer interface [polypeptide binding]; other site 456481001398 putative CoA binding site [chemical binding]; other site 456481001399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481001400 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 456481001401 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 456481001402 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 456481001403 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481001404 anti sigma factor interaction site; other site 456481001405 regulatory phosphorylation site [posttranslational modification]; other site 456481001406 DJ-1 family protein; Region: not_thiJ; TIGR01383 456481001407 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 456481001408 conserved cys residue [active] 456481001409 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 456481001410 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 456481001411 protein binding site [polypeptide binding]; other site 456481001412 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 456481001413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481001414 Walker A motif; other site 456481001415 ATP binding site [chemical binding]; other site 456481001416 Walker B motif; other site 456481001417 arginine finger; other site 456481001418 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 456481001419 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 456481001420 Beta-lactamase; Region: Beta-lactamase; pfam00144 456481001421 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 456481001422 Fe-S metabolism associated domain; Region: SufE; cl00951 456481001423 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 456481001424 metal binding site [ion binding]; metal-binding site 456481001425 nucleotidyl binding site; other site 456481001426 glycyl-tRNA synthetase; Provisional; Region: PRK14894 456481001427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 456481001428 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 456481001429 Transglycosylase; Region: Transgly; pfam00912 456481001430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 456481001431 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 456481001432 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 456481001433 active site 456481001434 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001435 Predicted permeases [General function prediction only]; Region: COG0795 456481001436 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 456481001437 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 456481001438 FAD binding domain; Region: FAD_binding_4; pfam01565 456481001439 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 456481001440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481001441 NAD(P) binding site [chemical binding]; other site 456481001442 active site 456481001443 YacP-like NYN domain; Region: NYN_YacP; cl01491 456481001444 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481001445 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481001446 FecR protein; Region: FecR; pfam04773 456481001447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481001448 dimerization interface [polypeptide binding]; other site 456481001449 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481001450 cyclase homology domain; Region: CHD; cd07302 456481001451 nucleotidyl binding site; other site 456481001452 metal binding site [ion binding]; metal-binding site 456481001453 dimer interface [polypeptide binding]; other site 456481001454 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 456481001455 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 456481001456 dimerization interface 3.5A [polypeptide binding]; other site 456481001457 active site 456481001458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 456481001459 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 456481001460 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481001461 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 456481001462 putative acyl-acceptor binding pocket; other site 456481001463 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 456481001464 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 456481001465 active site 456481001466 catalytic residues [active] 456481001467 Isochorismatase family; Region: Isochorismatase; pfam00857 456481001468 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 456481001469 conserved cis-peptide bond; other site 456481001470 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 456481001471 Sulfatase; Region: Sulfatase; pfam00884 456481001472 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 456481001473 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 456481001474 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481001475 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 456481001476 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 456481001477 carboxyltransferase (CT) interaction site; other site 456481001478 biotinylation site [posttranslational modification]; other site 456481001479 Surface antigen; Region: Bac_surface_Ag; pfam01103 456481001480 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 456481001481 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 456481001482 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 456481001483 G1 box; other site 456481001484 GTP/Mg2+ binding site [chemical binding]; other site 456481001485 Switch I region; other site 456481001486 G2 box; other site 456481001487 G3 box; other site 456481001488 Switch II region; other site 456481001489 G4 box; other site 456481001490 G5 box; other site 456481001491 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 456481001492 TilS substrate C-terminal domain; Region: TilS_C; cl17443 456481001493 GAF domain; Region: GAF_3; pfam13492 456481001494 GAF domain; Region: GAF_3; pfam13492 456481001495 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481001496 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001497 GAF domain; Region: GAF_2; pfam13185 456481001498 GAF domain; Region: GAF; pfam01590 456481001499 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 456481001500 GAF domain; Region: GAF; pfam01590 456481001501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481001502 Walker A motif; other site 456481001503 ATP binding site [chemical binding]; other site 456481001504 Walker B motif; other site 456481001505 arginine finger; other site 456481001506 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 456481001507 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 456481001508 dimer interface [polypeptide binding]; other site 456481001509 substrate binding site [chemical binding]; other site 456481001510 ATP binding site [chemical binding]; other site 456481001511 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 456481001512 DNA binding site [nucleotide binding] 456481001513 active site 456481001514 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 456481001515 dinuclear metal binding motif [ion binding]; other site 456481001516 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 456481001517 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 456481001518 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 456481001519 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481001520 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 456481001521 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 456481001522 FAD binding domain; Region: FAD_binding_4; pfam01565 456481001523 polyphosphate kinase; Provisional; Region: PRK05443 456481001524 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 456481001525 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 456481001526 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 456481001527 putative domain interface [polypeptide binding]; other site 456481001528 putative active site [active] 456481001529 catalytic site [active] 456481001530 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 456481001531 putative domain interface [polypeptide binding]; other site 456481001532 putative active site [active] 456481001533 catalytic site [active] 456481001534 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 456481001535 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 456481001536 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 456481001537 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 456481001538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481001539 motif II; other site 456481001540 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 456481001541 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481001542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481001543 S-adenosylmethionine binding site [chemical binding]; other site 456481001544 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 456481001545 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 456481001546 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 456481001547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 456481001548 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481001549 putative acyl-acceptor binding pocket; other site 456481001550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481001551 dimerization interface [polypeptide binding]; other site 456481001552 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481001553 cyclase homology domain; Region: CHD; cd07302 456481001554 nucleotidyl binding site; other site 456481001555 metal binding site [ion binding]; metal-binding site 456481001556 dimer interface [polypeptide binding]; other site 456481001557 MFS/sugar transport protein; Region: MFS_2; pfam13347 456481001558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481001559 putative substrate translocation pore; other site 456481001560 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001561 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001562 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481001563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481001564 binding surface 456481001565 TPR motif; other site 456481001566 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481001567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481001568 PAS domain; Region: PAS_9; pfam13426 456481001569 putative active site [active] 456481001570 heme pocket [chemical binding]; other site 456481001571 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481001572 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481001573 dimer interface [polypeptide binding]; other site 456481001574 putative CheW interface [polypeptide binding]; other site 456481001575 OsmC-like protein; Region: OsmC; pfam02566 456481001576 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 456481001577 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 456481001578 active site 456481001579 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 456481001580 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 456481001581 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 456481001582 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 456481001583 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 456481001584 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 456481001585 FMN binding site [chemical binding]; other site 456481001586 active site 456481001587 catalytic residues [active] 456481001588 substrate binding site [chemical binding]; other site 456481001589 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 456481001590 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 456481001591 PYR/PP interface [polypeptide binding]; other site 456481001592 dimer interface [polypeptide binding]; other site 456481001593 TPP binding site [chemical binding]; other site 456481001594 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 456481001595 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 456481001596 TPP-binding site [chemical binding]; other site 456481001597 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 456481001598 Predicted flavoprotein [General function prediction only]; Region: COG0431 456481001599 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 456481001600 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 456481001601 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 456481001602 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 456481001603 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 456481001604 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481001605 Predicted transcriptional regulators [Transcription]; Region: COG1695 456481001606 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 456481001607 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 456481001608 NMT1/THI5 like; Region: NMT1; pfam09084 456481001609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001610 dimer interface [polypeptide binding]; other site 456481001611 phosphorylation site [posttranslational modification] 456481001612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481001613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001614 ATP binding site [chemical binding]; other site 456481001615 Mg2+ binding site [ion binding]; other site 456481001616 G-X-G motif; other site 456481001617 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 456481001618 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 456481001619 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 456481001620 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 456481001621 classical (c) SDRs; Region: SDR_c; cd05233 456481001622 NAD(P) binding site [chemical binding]; other site 456481001623 active site 456481001624 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481001625 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481001626 ligand binding site [chemical binding]; other site 456481001627 flexible hinge region; other site 456481001628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481001629 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481001630 ligand binding site [chemical binding]; other site 456481001631 flexible hinge region; other site 456481001632 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481001633 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481001634 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481001635 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481001636 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481001637 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481001638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481001639 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481001640 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481001641 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481001642 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481001643 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481001644 Bacterial SH3 domain; Region: SH3_3; pfam08239 456481001645 Bacterial SH3 domain; Region: SH3_3; cl17532 456481001646 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481001647 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481001648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 456481001649 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 456481001650 DNA binding residues [nucleotide binding] 456481001651 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481001652 GAF domain; Region: GAF_3; pfam13492 456481001653 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481001654 GAF domain; Region: GAF; cl17456 456481001655 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481001656 cyclase homology domain; Region: CHD; cd07302 456481001657 nucleotidyl binding site; other site 456481001658 metal binding site [ion binding]; metal-binding site 456481001659 dimer interface [polypeptide binding]; other site 456481001660 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481001661 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481001662 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481001663 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481001664 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481001665 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481001666 GAF domain; Region: GAF_3; pfam13492 456481001667 Heme NO binding associated; Region: HNOBA; pfam07701 456481001668 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481001669 cyclase homology domain; Region: CHD; cd07302 456481001670 nucleotidyl binding site; other site 456481001671 metal binding site [ion binding]; metal-binding site 456481001672 dimer interface [polypeptide binding]; other site 456481001673 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 456481001674 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 456481001675 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 456481001676 catalytic residues [active] 456481001677 dimer interface [polypeptide binding]; other site 456481001678 Protein of unknown function, DUF399; Region: DUF399; pfam04187 456481001679 Transglycosylase; Region: Transgly; pfam00912 456481001680 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 456481001681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 456481001682 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 456481001683 active site 456481001684 NTP binding site [chemical binding]; other site 456481001685 metal binding triad [ion binding]; metal-binding site 456481001686 antibiotic binding site [chemical binding]; other site 456481001687 Protein of unknown function DUF86; Region: DUF86; cl01031 456481001688 transketolase; Reviewed; Region: PRK05899 456481001689 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 456481001690 TPP-binding site [chemical binding]; other site 456481001691 dimer interface [polypeptide binding]; other site 456481001692 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 456481001693 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 456481001694 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 456481001695 substrate binding pocket [chemical binding]; other site 456481001696 chain length determination region; other site 456481001697 substrate-Mg2+ binding site; other site 456481001698 catalytic residues [active] 456481001699 aspartate-rich region 1; other site 456481001700 active site lid residues [active] 456481001701 aspartate-rich region 2; other site 456481001702 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481001703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001704 dimer interface [polypeptide binding]; other site 456481001705 phosphorylation site [posttranslational modification] 456481001706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481001707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001708 ATP binding site [chemical binding]; other site 456481001709 Mg2+ binding site [ion binding]; other site 456481001710 G-X-G motif; other site 456481001711 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 456481001712 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 456481001713 Cl- selectivity filter; other site 456481001714 Cl- binding residues [ion binding]; other site 456481001715 pore gating glutamate residue; other site 456481001716 dimer interface [polypeptide binding]; other site 456481001717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 456481001718 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 456481001719 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 456481001720 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 456481001721 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 456481001722 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 456481001723 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 456481001724 homodimer interface [polypeptide binding]; other site 456481001725 metal binding site [ion binding]; metal-binding site 456481001726 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 456481001727 homodimer interface [polypeptide binding]; other site 456481001728 active site 456481001729 putative chemical substrate binding site [chemical binding]; other site 456481001730 metal binding site [ion binding]; metal-binding site 456481001731 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 456481001732 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 456481001733 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 456481001734 trimer interface [polypeptide binding]; other site 456481001735 active site 456481001736 UDP-GlcNAc binding site [chemical binding]; other site 456481001737 lipid binding site [chemical binding]; lipid-binding site 456481001738 Predicted membrane protein [Function unknown]; Region: COG2259 456481001739 RibD C-terminal domain; Region: RibD_C; pfam01872 456481001740 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 456481001741 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 456481001742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481001743 putative substrate translocation pore; other site 456481001744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 456481001745 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 456481001746 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 456481001747 Predicted transcriptional regulator [Transcription]; Region: COG2378 456481001748 WYL domain; Region: WYL; pfam13280 456481001749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481001750 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481001751 putative substrate translocation pore; other site 456481001752 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 456481001753 heme binding pocket [chemical binding]; other site 456481001754 heme ligand [chemical binding]; other site 456481001755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 456481001756 DNA polymerase I; Provisional; Region: PRK05755 456481001757 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 456481001758 active site 456481001759 metal binding site 1 [ion binding]; metal-binding site 456481001760 putative 5' ssDNA interaction site; other site 456481001761 metal binding site 3; metal-binding site 456481001762 metal binding site 2 [ion binding]; metal-binding site 456481001763 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 456481001764 putative DNA binding site [nucleotide binding]; other site 456481001765 putative metal binding site [ion binding]; other site 456481001766 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 456481001767 active site 456481001768 catalytic site [active] 456481001769 substrate binding site [chemical binding]; other site 456481001770 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 456481001771 active site 456481001772 DNA binding site [nucleotide binding] 456481001773 catalytic site [active] 456481001774 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 456481001775 putative ADP-binding pocket [chemical binding]; other site 456481001776 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481001777 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481001778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 456481001779 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 456481001780 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 456481001781 HIGH motif; other site 456481001782 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 456481001783 active site 456481001784 KMSKS motif; other site 456481001785 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 456481001786 CAP-like domain; other site 456481001787 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 456481001788 active site 456481001789 primary dimer interface [polypeptide binding]; other site 456481001790 TopoisomeraseII; Region: TOP2c; smart00433 456481001791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001792 ATP binding site [chemical binding]; other site 456481001793 Mg2+ binding site [ion binding]; other site 456481001794 G-X-G motif; other site 456481001795 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 456481001796 ATP binding site [chemical binding]; other site 456481001797 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 456481001798 active site 456481001799 putative metal-binding site [ion binding]; other site 456481001800 Beta-lactamase; Region: Beta-lactamase; pfam00144 456481001801 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 456481001802 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 456481001803 Protein of unknown function (DUF445); Region: DUF445; pfam04286 456481001804 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 456481001805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481001806 NAD(P) binding site [chemical binding]; other site 456481001807 active site 456481001808 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 456481001809 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 456481001810 Coenzyme A binding pocket [chemical binding]; other site 456481001811 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 456481001812 DNA protecting protein DprA; Region: dprA; TIGR00732 456481001813 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 456481001814 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 456481001815 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 456481001816 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 456481001817 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 456481001818 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481001819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481001820 catalytic residue [active] 456481001821 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 456481001822 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 456481001823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481001824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481001825 homodimer interface [polypeptide binding]; other site 456481001826 catalytic residue [active] 456481001827 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 456481001828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481001829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481001830 catalytic residue [active] 456481001831 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 456481001832 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 456481001833 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 456481001834 C-terminal domain interface [polypeptide binding]; other site 456481001835 GSH binding site (G-site) [chemical binding]; other site 456481001836 dimer interface [polypeptide binding]; other site 456481001837 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481001838 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481001839 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 456481001840 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481001841 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481001842 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 456481001843 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 456481001844 Bacterial SH3 domain; Region: SH3_3; cl17532 456481001845 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 456481001846 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 456481001847 dimer interface [polypeptide binding]; other site 456481001848 active site 456481001849 ketol-acid reductoisomerase; Provisional; Region: PRK05479 456481001850 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 456481001851 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 456481001852 MASE1; Region: MASE1; cl17823 456481001853 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481001854 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481001855 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 456481001856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481001857 Walker A/P-loop; other site 456481001858 ATP binding site [chemical binding]; other site 456481001859 Q-loop/lid; other site 456481001860 ABC transporter signature motif; other site 456481001861 Walker B; other site 456481001862 D-loop; other site 456481001863 H-loop/switch region; other site 456481001864 ABC transporter; Region: ABC_tran_2; pfam12848 456481001865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481001866 PAS fold; Region: PAS_3; pfam08447 456481001867 PAS fold; Region: PAS; pfam00989 456481001868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481001869 putative active site [active] 456481001870 heme pocket [chemical binding]; other site 456481001871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481001872 PAS fold; Region: PAS_3; pfam08447 456481001873 putative active site [active] 456481001874 heme pocket [chemical binding]; other site 456481001875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481001876 dimer interface [polypeptide binding]; other site 456481001877 phosphorylation site [posttranslational modification] 456481001878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481001879 ATP binding site [chemical binding]; other site 456481001880 Mg2+ binding site [ion binding]; other site 456481001881 G-X-G motif; other site 456481001882 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481001883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481001884 active site 456481001885 phosphorylation site [posttranslational modification] 456481001886 intermolecular recognition site; other site 456481001887 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481001889 active site 456481001890 phosphorylation site [posttranslational modification] 456481001891 intermolecular recognition site; other site 456481001892 dimerization interface [polypeptide binding]; other site 456481001893 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 456481001894 Domain of unknown function DUF21; Region: DUF21; pfam01595 456481001895 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 456481001896 Transporter associated domain; Region: CorC_HlyC; smart01091 456481001897 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 456481001898 Flavoprotein; Region: Flavoprotein; pfam02441 456481001899 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 456481001900 Protein of unknown function, DUF486; Region: DUF486; cl01236 456481001901 NAD-dependent deacetylase; Provisional; Region: PRK00481 456481001902 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 456481001903 NAD+ binding site [chemical binding]; other site 456481001904 substrate binding site [chemical binding]; other site 456481001905 Zn binding site [ion binding]; other site 456481001906 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 456481001907 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 456481001908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481001909 catalytic residue [active] 456481001910 Cytochrome C biogenesis protein; Region: CcmH; cl01179 456481001911 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 456481001912 CcmE; Region: CcmE; cl00994 456481001913 Uncharacterized conserved protein [Function unknown]; Region: COG1434 456481001914 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 456481001915 putative active site [active] 456481001916 acetolactate synthase catalytic subunit; Reviewed; Region: PRK06276 456481001917 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 456481001918 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 456481001919 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 456481001920 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 456481001921 transmembrane helices; other site 456481001922 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 456481001923 active sites [active] 456481001924 tetramer interface [polypeptide binding]; other site 456481001925 Domain of unknown function (DUF368); Region: DUF368; pfam04018 456481001926 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 456481001927 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 456481001928 Mg++ binding site [ion binding]; other site 456481001929 putative catalytic motif [active] 456481001930 putative substrate binding site [chemical binding]; other site 456481001931 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 456481001932 dihydrodipicolinate synthase; Region: dapA; TIGR00674 456481001933 dimer interface [polypeptide binding]; other site 456481001934 active site 456481001935 catalytic residue [active] 456481001936 dihydrodipicolinate reductase; Provisional; Region: PRK00048 456481001937 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 456481001938 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 456481001939 Uncharacterized conserved protein [Function unknown]; Region: COG1624 456481001940 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 456481001941 YbbR-like protein; Region: YbbR; pfam07949 456481001942 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481001943 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 456481001944 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481001945 cyclase homology domain; Region: CHD; cd07302 456481001946 nucleotidyl binding site; other site 456481001947 metal binding site [ion binding]; metal-binding site 456481001948 dimer interface [polypeptide binding]; other site 456481001949 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 456481001950 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 456481001951 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 456481001952 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 456481001953 PemK-like protein; Region: PemK; pfam02452 456481001954 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 456481001955 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481001956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481001957 catalytic residue [active] 456481001958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481001959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481001960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481001961 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 456481001962 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 456481001963 N- and C-terminal domain interface [polypeptide binding]; other site 456481001964 active site 456481001965 MgATP binding site [chemical binding]; other site 456481001966 catalytic site [active] 456481001967 metal binding site [ion binding]; metal-binding site 456481001968 xylulose binding site [chemical binding]; other site 456481001969 putative homodimer interface [polypeptide binding]; other site 456481001970 Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172 456481001971 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 456481001972 active site 456481001973 substrate binding site [chemical binding]; other site 456481001974 ATP binding site [chemical binding]; other site 456481001975 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 456481001976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 456481001977 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 456481001978 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12729 456481001979 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 456481001980 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 456481001981 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 456481001982 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624 456481001983 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 456481001984 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 456481001985 PLD-like domain; Region: PLDc_2; pfam13091 456481001986 putative homodimer interface [polypeptide binding]; other site 456481001987 putative active site [active] 456481001988 catalytic site [active] 456481001989 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 456481001990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481001991 ATP binding site [chemical binding]; other site 456481001992 putative Mg++ binding site [ion binding]; other site 456481001993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481001994 nucleotide binding region [chemical binding]; other site 456481001995 ATP-binding site [chemical binding]; other site 456481001996 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 456481001997 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 456481001998 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 456481001999 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 456481002000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481002001 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 456481002002 Permease; Region: Permease; pfam02405 456481002003 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 456481002004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481002005 Walker A/P-loop; other site 456481002006 ATP binding site [chemical binding]; other site 456481002007 Q-loop/lid; other site 456481002008 ABC transporter signature motif; other site 456481002009 Walker B; other site 456481002010 D-loop; other site 456481002011 H-loop/switch region; other site 456481002012 mce related protein; Region: MCE; pfam02470 456481002013 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 456481002014 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 456481002015 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 456481002016 dimer interface [polypeptide binding]; other site 456481002017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481002018 active site 456481002019 metal binding site [ion binding]; metal-binding site 456481002020 glutathione binding site [chemical binding]; other site 456481002021 flavoprotein, HI0933 family; Region: TIGR00275 456481002022 pyruvate kinase; Provisional; Region: PRK05826 456481002023 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 456481002024 domain interfaces; other site 456481002025 active site 456481002026 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 456481002027 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 456481002028 putative active site [active] 456481002029 Zn binding site [ion binding]; other site 456481002030 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002032 active site 456481002033 phosphorylation site [posttranslational modification] 456481002034 intermolecular recognition site; other site 456481002035 dimerization interface [polypeptide binding]; other site 456481002036 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481002037 Melibiase; Region: Melibiase; pfam02065 456481002038 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 456481002039 catalytic site [active] 456481002040 putative active site [active] 456481002041 putative substrate binding site [chemical binding]; other site 456481002042 DNA repair protein RadA; Provisional; Region: PRK11823 456481002043 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 456481002044 Walker A motif; other site 456481002045 ATP binding site [chemical binding]; other site 456481002046 Walker B motif; other site 456481002047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 456481002048 PGAP1-like protein; Region: PGAP1; pfam07819 456481002049 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 456481002050 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 456481002051 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 456481002052 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 456481002053 active site 456481002054 Zn binding site [ion binding]; other site 456481002055 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 456481002056 Putative Ig domain; Region: He_PIG; pfam05345 456481002057 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 456481002058 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 456481002059 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 456481002060 tetrameric interface [polypeptide binding]; other site 456481002061 activator binding site; other site 456481002062 NADP binding site [chemical binding]; other site 456481002063 substrate binding site [chemical binding]; other site 456481002064 catalytic residues [active] 456481002065 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 456481002066 putative active site [active] 456481002067 putative catalytic site [active] 456481002068 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 456481002069 active site 2 [active] 456481002070 active site 1 [active] 456481002071 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 456481002072 Predicted membrane protein (DUF2206); Region: DUF2206; pfam09971 456481002073 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 456481002074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 456481002075 Catalytic site [active] 456481002076 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 456481002077 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 456481002078 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 456481002079 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 456481002080 PYR/PP interface [polypeptide binding]; other site 456481002081 dimer interface [polypeptide binding]; other site 456481002082 TPP binding site [chemical binding]; other site 456481002083 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 456481002084 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 456481002085 TPP-binding site [chemical binding]; other site 456481002086 dimer interface [polypeptide binding]; other site 456481002087 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 456481002088 Nitrogen regulatory protein P-II; Region: P-II; smart00938 456481002089 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 456481002090 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 456481002091 catalytic residues [active] 456481002092 dimer interface [polypeptide binding]; other site 456481002093 Transcriptional regulators [Transcription]; Region: MarR; COG1846 456481002094 MarR family; Region: MarR; pfam01047 456481002095 F0F1 ATP synthase subunit A; Provisional; Region: PRK13417 456481002096 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 456481002097 F0F1 ATP synthase subunit B; Provisional; Region: PRK13460 456481002098 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 456481002099 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13434 456481002100 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 456481002101 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 456481002102 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 456481002103 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 456481002104 beta subunit interaction interface [polypeptide binding]; other site 456481002105 Walker A motif; other site 456481002106 ATP binding site [chemical binding]; other site 456481002107 Walker B motif; other site 456481002108 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 456481002109 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 456481002110 core domain interface [polypeptide binding]; other site 456481002111 delta subunit interface [polypeptide binding]; other site 456481002112 epsilon subunit interface [polypeptide binding]; other site 456481002113 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 456481002114 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 456481002115 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 456481002116 alpha subunit interaction interface [polypeptide binding]; other site 456481002117 Walker A motif; other site 456481002118 ATP binding site [chemical binding]; other site 456481002119 Walker B motif; other site 456481002120 inhibitor binding site; inhibition site 456481002121 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 456481002122 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444 456481002123 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 456481002124 gamma subunit interface [polypeptide binding]; other site 456481002125 epsilon subunit interface [polypeptide binding]; other site 456481002126 LBP interface [polypeptide binding]; other site 456481002127 SLBB domain; Region: SLBB; pfam10531 456481002128 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481002129 GAF domain; Region: GAF_3; pfam13492 456481002130 GAF domain; Region: GAF_3; pfam13492 456481002131 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481002132 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 456481002133 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 456481002134 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 456481002135 catalytic site [active] 456481002136 subunit interface [polypeptide binding]; other site 456481002137 Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389 456481002138 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 456481002139 aromatic arch; other site 456481002140 DCoH dimer interaction site [polypeptide binding]; other site 456481002141 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 456481002142 DCoH tetramer interaction site [polypeptide binding]; other site 456481002143 substrate binding site [chemical binding]; other site 456481002144 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 456481002145 EamA-like transporter family; Region: EamA; pfam00892 456481002146 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 456481002147 ligand binding site [chemical binding]; other site 456481002148 active site 456481002149 UGI interface [polypeptide binding]; other site 456481002150 catalytic site [active] 456481002151 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 456481002152 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 456481002153 EamA-like transporter family; Region: EamA; pfam00892 456481002154 EamA-like transporter family; Region: EamA; pfam00892 456481002155 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 456481002156 Domain of unknown function DUF20; Region: UPF0118; pfam01594 456481002157 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481002158 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481002159 ligand binding site [chemical binding]; other site 456481002160 flexible hinge region; other site 456481002161 AAA domain; Region: AAA_26; pfam13500 456481002162 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 456481002163 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 456481002164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 456481002165 inhibitor-cofactor binding pocket; inhibition site 456481002166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481002167 catalytic residue [active] 456481002168 biotin synthase; Region: bioB; TIGR00433 456481002169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481002170 FeS/SAM binding site; other site 456481002171 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 456481002172 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 456481002173 MFS/sugar transport protein; Region: MFS_2; pfam13347 456481002174 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 456481002175 active site 456481002176 catalytic triad [active] 456481002177 oxyanion hole [active] 456481002178 phosphoserine phosphatase SerB; Region: serB; TIGR00338 456481002179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481002180 active site 456481002181 motif I; other site 456481002182 motif II; other site 456481002183 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 456481002184 MutS domain I; Region: MutS_I; pfam01624 456481002185 MutS domain II; Region: MutS_II; pfam05188 456481002186 MutS domain III; Region: MutS_III; pfam05192 456481002187 MutS domain V; Region: MutS_V; pfam00488 456481002188 Walker A/P-loop; other site 456481002189 ATP binding site [chemical binding]; other site 456481002190 Q-loop/lid; other site 456481002191 ABC transporter signature motif; other site 456481002192 Walker B; other site 456481002193 D-loop; other site 456481002194 H-loop/switch region; other site 456481002195 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 456481002196 active site 456481002197 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 456481002198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481002199 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 456481002200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 456481002201 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 456481002202 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 456481002203 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 456481002204 shikimate binding site; other site 456481002205 NAD(P) binding site [chemical binding]; other site 456481002206 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 456481002207 putative metal binding site; other site 456481002208 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 456481002209 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481002210 RNA binding site [nucleotide binding]; other site 456481002211 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 456481002212 RNA binding site [nucleotide binding]; other site 456481002213 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 456481002214 RNA binding site [nucleotide binding]; other site 456481002215 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 456481002216 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481002217 excinuclease ABC subunit B; Provisional; Region: PRK05298 456481002218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481002219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481002220 Walker A/P-loop; other site 456481002221 ATP binding site [chemical binding]; other site 456481002222 ATP binding site [chemical binding]; other site 456481002223 putative Mg++ binding site [ion binding]; other site 456481002224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481002225 nucleotide binding region [chemical binding]; other site 456481002226 ATP-binding site [chemical binding]; other site 456481002227 Ultra-violet resistance protein B; Region: UvrB; pfam12344 456481002228 UvrB/uvrC motif; Region: UVR; pfam02151 456481002229 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 456481002230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481002231 Walker A motif; other site 456481002232 ATP binding site [chemical binding]; other site 456481002233 Walker B motif; other site 456481002234 arginine finger; other site 456481002235 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 456481002236 Transglycosylase; Region: Transgly; pfam00912 456481002237 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 456481002238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 456481002239 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 456481002240 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 456481002241 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 456481002242 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481002243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481002244 Walker A/P-loop; other site 456481002245 ATP binding site [chemical binding]; other site 456481002246 Q-loop/lid; other site 456481002247 ABC transporter signature motif; other site 456481002248 Walker B; other site 456481002249 D-loop; other site 456481002250 H-loop/switch region; other site 456481002251 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 456481002252 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 456481002253 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 456481002254 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 456481002255 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 456481002256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481002257 Methyltransferase domain; Region: Methyltransf_31; pfam13847 456481002258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481002259 S-adenosylmethionine binding site [chemical binding]; other site 456481002260 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 456481002261 Protein export membrane protein; Region: SecD_SecF; cl14618 456481002262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481002263 dimerization interface [polypeptide binding]; other site 456481002264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481002265 dimer interface [polypeptide binding]; other site 456481002266 phosphorylation site [posttranslational modification] 456481002267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002269 ATP binding site [chemical binding]; other site 456481002270 Mg2+ binding site [ion binding]; other site 456481002271 G-X-G motif; other site 456481002272 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 456481002273 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 456481002274 N-acetyl-D-glucosamine binding site [chemical binding]; other site 456481002275 catalytic residue [active] 456481002276 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 456481002277 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 456481002278 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 456481002279 active site 456481002280 TPR repeat; Region: TPR_11; pfam13414 456481002281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481002282 binding surface 456481002283 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 456481002284 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 456481002285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481002286 substrate binding site [chemical binding]; other site 456481002287 oxyanion hole (OAH) forming residues; other site 456481002288 trimer interface [polypeptide binding]; other site 456481002289 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481002290 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 456481002291 ligand binding site [chemical binding]; other site 456481002292 flexible hinge region; other site 456481002293 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 456481002294 putative switch regulator; other site 456481002295 non-specific DNA interactions [nucleotide binding]; other site 456481002296 DNA binding site [nucleotide binding] 456481002297 sequence specific DNA binding site [nucleotide binding]; other site 456481002298 putative cAMP binding site [chemical binding]; other site 456481002299 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 456481002300 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 456481002301 putative active site pocket [active] 456481002302 4-fold oligomerization interface [polypeptide binding]; other site 456481002303 metal binding residues [ion binding]; metal-binding site 456481002304 3-fold/trimer interface [polypeptide binding]; other site 456481002305 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK14004 456481002306 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 456481002307 putative active site [active] 456481002308 oxyanion strand; other site 456481002309 catalytic triad [active] 456481002310 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 456481002311 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 456481002312 catalytic residues [active] 456481002313 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 456481002314 putative active site [active] 456481002315 redox center [active] 456481002316 Thioredoxin; Region: Thioredoxin_4; pfam13462 456481002317 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 456481002318 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 456481002319 NeuB family; Region: NeuB; pfam03102 456481002320 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 456481002321 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 456481002322 G1 box; other site 456481002323 GTP/Mg2+ binding site [chemical binding]; other site 456481002324 Switch I region; other site 456481002325 G2 box; other site 456481002326 G3 box; other site 456481002327 Switch II region; other site 456481002328 G4 box; other site 456481002329 G5 box; other site 456481002330 Nucleoside recognition; Region: Gate; pfam07670 456481002331 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 456481002332 Nucleoside recognition; Region: Gate; pfam07670 456481002333 FeoA domain; Region: FeoA; pfam04023 456481002334 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 456481002335 ABC1 family; Region: ABC1; cl17513 456481002336 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 456481002337 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 456481002338 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 456481002339 putative active site [active] 456481002340 catalytic triad [active] 456481002341 putative dimer interface [polypeptide binding]; other site 456481002342 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 456481002343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481002344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481002345 Repair protein; Region: Repair_PSII; pfam04536 456481002346 glycyl-tRNA synthetase; Provisional; Region: PRK04173 456481002347 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 456481002348 motif 1; other site 456481002349 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 456481002350 active site 456481002351 motif 2; other site 456481002352 motif 3; other site 456481002353 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 456481002354 anticodon binding site; other site 456481002355 Protease prsW family; Region: PrsW-protease; pfam13367 456481002356 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 456481002357 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 456481002358 putative dimer interface [polypeptide binding]; other site 456481002359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481002360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481002361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481002362 WHG domain; Region: WHG; pfam13305 456481002363 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 456481002364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481002365 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 456481002366 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 456481002367 FAD binding pocket [chemical binding]; other site 456481002368 FAD binding motif [chemical binding]; other site 456481002369 phosphate binding motif [ion binding]; other site 456481002370 beta-alpha-beta structure motif; other site 456481002371 NAD binding pocket [chemical binding]; other site 456481002372 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 456481002373 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 456481002374 catalytic loop [active] 456481002375 iron binding site [ion binding]; other site 456481002376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481002377 PAS domain; Region: PAS_9; pfam13426 456481002378 putative active site [active] 456481002379 heme pocket [chemical binding]; other site 456481002380 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 456481002381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481002382 putative active site [active] 456481002383 heme pocket [chemical binding]; other site 456481002384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481002385 dimer interface [polypeptide binding]; other site 456481002386 phosphorylation site [posttranslational modification] 456481002387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002388 ATP binding site [chemical binding]; other site 456481002389 Mg2+ binding site [ion binding]; other site 456481002390 G-X-G motif; other site 456481002391 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002393 active site 456481002394 phosphorylation site [posttranslational modification] 456481002395 intermolecular recognition site; other site 456481002396 dimerization interface [polypeptide binding]; other site 456481002397 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 456481002398 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 456481002399 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481002400 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481002401 anti sigma factor interaction site; other site 456481002402 regulatory phosphorylation site [posttranslational modification]; other site 456481002403 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 456481002404 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 456481002405 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 456481002406 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 456481002407 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 456481002408 protein binding site [polypeptide binding]; other site 456481002409 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 456481002410 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481002411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481002412 homodimer interface [polypeptide binding]; other site 456481002413 catalytic residue [active] 456481002414 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 456481002415 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 456481002416 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 456481002417 dimerization interface [polypeptide binding]; other site 456481002418 putative ATP binding site [chemical binding]; other site 456481002419 PAS fold; Region: PAS_3; pfam08447 456481002420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481002421 PAS domain; Region: PAS_9; pfam13426 456481002422 putative active site [active] 456481002423 heme pocket [chemical binding]; other site 456481002424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481002425 dimer interface [polypeptide binding]; other site 456481002426 phosphorylation site [posttranslational modification] 456481002427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002429 ATP binding site [chemical binding]; other site 456481002430 Mg2+ binding site [ion binding]; other site 456481002431 G-X-G motif; other site 456481002432 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002434 active site 456481002435 phosphorylation site [posttranslational modification] 456481002436 intermolecular recognition site; other site 456481002437 dimerization interface [polypeptide binding]; other site 456481002438 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002440 active site 456481002441 phosphorylation site [posttranslational modification] 456481002442 intermolecular recognition site; other site 456481002443 dimerization interface [polypeptide binding]; other site 456481002444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 456481002445 active site 456481002446 phosphorylation site [posttranslational modification] 456481002447 intermolecular recognition site; other site 456481002448 dimerization interface [polypeptide binding]; other site 456481002449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002451 ATP binding site [chemical binding]; other site 456481002452 Mg2+ binding site [ion binding]; other site 456481002453 G-X-G motif; other site 456481002454 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 456481002455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002456 active site 456481002457 phosphorylation site [posttranslational modification] 456481002458 intermolecular recognition site; other site 456481002459 dimerization interface [polypeptide binding]; other site 456481002460 CheB methylesterase; Region: CheB_methylest; pfam01339 456481002461 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 456481002462 putative binding surface; other site 456481002463 active site 456481002464 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 456481002465 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 456481002466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002467 ATP binding site [chemical binding]; other site 456481002468 Mg2+ binding site [ion binding]; other site 456481002469 G-X-G motif; other site 456481002470 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 456481002471 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 456481002472 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 456481002473 HAMP domain; Region: HAMP; pfam00672 456481002474 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481002475 dimer interface [polypeptide binding]; other site 456481002476 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 456481002477 putative CheW interface [polypeptide binding]; other site 456481002478 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481002479 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 456481002480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481002481 substrate binding site [chemical binding]; other site 456481002482 oxyanion hole (OAH) forming residues; other site 456481002483 trimer interface [polypeptide binding]; other site 456481002484 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 456481002485 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 456481002486 homodimer interface [polypeptide binding]; other site 456481002487 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 456481002488 active site pocket [active] 456481002489 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002491 active site 456481002492 phosphorylation site [posttranslational modification] 456481002493 intermolecular recognition site; other site 456481002494 dimerization interface [polypeptide binding]; other site 456481002495 HEAT repeats; Region: HEAT_2; pfam13646 456481002496 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 456481002497 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 456481002498 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 456481002499 Walker A/P-loop; other site 456481002500 ATP binding site [chemical binding]; other site 456481002501 Q-loop/lid; other site 456481002502 ABC transporter signature motif; other site 456481002503 Walker B; other site 456481002504 D-loop; other site 456481002505 H-loop/switch region; other site 456481002506 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 456481002507 putative carbohydrate binding site [chemical binding]; other site 456481002508 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 456481002509 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 456481002510 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 456481002511 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 456481002512 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 456481002513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481002514 TPR repeat; Region: TPR_11; pfam13414 456481002515 binding surface 456481002516 TPR motif; other site 456481002517 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 456481002518 metal binding site [ion binding]; metal-binding site 456481002519 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 456481002520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481002521 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 456481002522 Uncharacterized conserved protein [Function unknown]; Region: COG4121 456481002523 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724 456481002524 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 456481002525 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 456481002526 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 456481002527 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 456481002528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481002529 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 456481002530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481002531 DNA binding residues [nucleotide binding] 456481002532 Protein of unknown function (DUF342); Region: DUF342; pfam03961 456481002533 hypothetical protein; Provisional; Region: PRK04323 456481002534 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 456481002535 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 456481002536 catalytic site [active] 456481002537 G-X2-G-X-G-K; other site 456481002538 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 456481002539 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 456481002540 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481002541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481002543 dimer interface [polypeptide binding]; other site 456481002544 phosphorylation site [posttranslational modification] 456481002545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002546 ATP binding site [chemical binding]; other site 456481002547 Mg2+ binding site [ion binding]; other site 456481002548 G-X-G motif; other site 456481002549 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002551 active site 456481002552 phosphorylation site [posttranslational modification] 456481002553 intermolecular recognition site; other site 456481002554 dimerization interface [polypeptide binding]; other site 456481002555 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481002556 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481002557 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 456481002558 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 456481002559 Walker A motif; other site 456481002560 ATP binding site [chemical binding]; other site 456481002561 Walker B motif; other site 456481002562 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 456481002563 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 456481002564 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 456481002565 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 456481002566 hinge; other site 456481002567 active site 456481002568 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 456481002569 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 456481002570 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 456481002571 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 456481002572 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481002573 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481002574 ligand binding site [chemical binding]; other site 456481002575 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 456481002576 active site 456481002577 catalytic triad [active] 456481002578 oxyanion hole [active] 456481002579 switch loop; other site 456481002580 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 456481002581 trigger factor; Region: tig; TIGR00115 456481002582 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 456481002583 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 456481002584 Clp protease; Region: CLP_protease; pfam00574 456481002585 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 456481002586 oligomer interface [polypeptide binding]; other site 456481002587 active site residues [active] 456481002588 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 456481002589 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 456481002590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481002591 Walker A motif; other site 456481002592 ATP binding site [chemical binding]; other site 456481002593 Walker B motif; other site 456481002594 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 456481002595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 456481002596 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 456481002597 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 456481002598 PAS domain S-box; Region: sensory_box; TIGR00229 456481002599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481002601 dimer interface [polypeptide binding]; other site 456481002602 phosphorylation site [posttranslational modification] 456481002603 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002605 active site 456481002606 phosphorylation site [posttranslational modification] 456481002607 intermolecular recognition site; other site 456481002608 dimerization interface [polypeptide binding]; other site 456481002609 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481002610 PGAP1-like protein; Region: PGAP1; pfam07819 456481002611 Protein of unknown function (DUF461); Region: DUF461; pfam04314 456481002612 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 456481002613 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 456481002614 Cu(I) binding site [ion binding]; other site 456481002615 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 456481002616 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 456481002617 active site 456481002618 Zn binding site [ion binding]; other site 456481002619 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 456481002620 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 456481002621 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 456481002622 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 456481002623 FecR protein; Region: FecR; pfam04773 456481002624 Outer membrane efflux protein; Region: OEP; pfam02321 456481002625 Bacterial Ig-like domain; Region: Big_5; pfam13205 456481002626 Bacterial Ig-like domain; Region: Big_5; pfam13205 456481002627 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 456481002628 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 456481002629 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481002630 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 456481002631 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 456481002632 cyclase homology domain; Region: CHD; cd07302 456481002633 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481002634 nucleotidyl binding site; other site 456481002635 metal binding site [ion binding]; metal-binding site 456481002636 dimer interface [polypeptide binding]; other site 456481002637 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 456481002638 Uncharacterized conserved protein [Function unknown]; Region: COG3589 456481002639 O-Antigen ligase; Region: Wzy_C; pfam04932 456481002640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481002641 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 456481002642 putative ADP-binding pocket [chemical binding]; other site 456481002643 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 456481002644 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 456481002645 putative active site [active] 456481002646 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 456481002647 NRDE protein; Region: NRDE; cl01315 456481002648 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 456481002649 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 456481002650 dimer interface [polypeptide binding]; other site 456481002651 active site 456481002652 glycine-pyridoxal phosphate binding site [chemical binding]; other site 456481002653 folate binding site [chemical binding]; other site 456481002654 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 456481002655 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 456481002656 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 456481002657 glycosyltransferase; Provisional; Region: PRK13481 456481002658 Transglycosylase; Region: Transgly; pfam00912 456481002659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 456481002660 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481002661 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481002662 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 456481002663 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 456481002664 tandem repeat interface [polypeptide binding]; other site 456481002665 oligomer interface [polypeptide binding]; other site 456481002666 active site residues [active] 456481002667 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 456481002668 active site 456481002669 catalytic residues [active] 456481002670 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 456481002671 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 456481002672 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 456481002673 endonuclease III; Region: ENDO3c; smart00478 456481002674 minor groove reading motif; other site 456481002675 helix-hairpin-helix signature motif; other site 456481002676 substrate binding pocket [chemical binding]; other site 456481002677 active site 456481002678 prenyltransferase; Reviewed; Region: ubiA; PRK12886 456481002679 UbiA prenyltransferase family; Region: UbiA; pfam01040 456481002680 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 456481002681 Flavoprotein; Region: Flavoprotein; pfam02441 456481002682 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 456481002683 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 456481002684 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 456481002685 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 456481002686 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 456481002687 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 456481002688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481002689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481002690 homodimer interface [polypeptide binding]; other site 456481002691 catalytic residue [active] 456481002692 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 456481002693 transcription termination factor Rho; Provisional; Region: rho; PRK09376 456481002694 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 456481002695 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 456481002696 RNA binding site [nucleotide binding]; other site 456481002697 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 456481002698 multimer interface [polypeptide binding]; other site 456481002699 Walker A motif; other site 456481002700 ATP binding site [chemical binding]; other site 456481002701 Walker B motif; other site 456481002702 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 456481002703 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 456481002704 active site 456481002705 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 456481002706 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 456481002707 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 456481002708 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481002709 anti sigma factor interaction site; other site 456481002710 regulatory phosphorylation site [posttranslational modification]; other site 456481002711 Protein of unknown function (DUF342); Region: DUF342; pfam03961 456481002712 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 456481002713 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 456481002714 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 456481002715 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 456481002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 456481002717 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481002718 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481002719 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481002720 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481002721 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 456481002722 dimer interface [polypeptide binding]; other site 456481002723 Citrate synthase; Region: Citrate_synt; pfam00285 456481002724 active site 456481002725 citrylCoA binding site [chemical binding]; other site 456481002726 NADH binding [chemical binding]; other site 456481002727 cationic pore residues; other site 456481002728 oxalacetate/citrate binding site [chemical binding]; other site 456481002729 coenzyme A binding site [chemical binding]; other site 456481002730 catalytic triad [active] 456481002731 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 456481002732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 456481002733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 456481002734 catalytic residue [active] 456481002735 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 456481002736 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 456481002737 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 456481002738 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 456481002739 inhibitor-cofactor binding pocket; inhibition site 456481002740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481002741 catalytic residue [active] 456481002742 TRL-like protein family; Region: TRL; pfam13146 456481002743 TRL-like protein family; Region: TRL; pfam13146 456481002744 TRL-like protein family; Region: TRL; pfam13146 456481002745 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 456481002746 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 456481002747 TPP-binding site [chemical binding]; other site 456481002748 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 456481002749 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 456481002750 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481002751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481002752 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 456481002753 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 456481002754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 456481002755 E3 interaction surface; other site 456481002756 lipoyl attachment site [posttranslational modification]; other site 456481002757 e3 binding domain; Region: E3_binding; pfam02817 456481002758 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 456481002759 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 456481002760 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 456481002761 trimer interface [polypeptide binding]; other site 456481002762 putative metal binding site [ion binding]; other site 456481002763 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481002764 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481002765 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481002766 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481002767 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481002768 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481002769 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 456481002770 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 456481002771 Multicopper oxidase; Region: Cu-oxidase; pfam00394 456481002772 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 456481002773 Cytochrome c; Region: Cytochrom_C; pfam00034 456481002774 Uncharacterized conserved protein [Function unknown]; Region: COG1262 456481002775 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 456481002776 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 456481002777 Cu(I) binding site [ion binding]; other site 456481002778 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481002779 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 456481002780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481002781 NAD(P) binding site [chemical binding]; other site 456481002782 active site 456481002783 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481002784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481002786 dimer interface [polypeptide binding]; other site 456481002787 phosphorylation site [posttranslational modification] 456481002788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002789 ATP binding site [chemical binding]; other site 456481002790 Mg2+ binding site [ion binding]; other site 456481002791 G-X-G motif; other site 456481002792 Response regulator receiver domain; Region: Response_reg; pfam00072 456481002793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002794 active site 456481002795 phosphorylation site [posttranslational modification] 456481002796 intermolecular recognition site; other site 456481002797 dimerization interface [polypeptide binding]; other site 456481002798 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 456481002799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481002800 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 456481002801 OmpA family; Region: OmpA; pfam00691 456481002802 ligand binding site [chemical binding]; other site 456481002803 malate:quinone oxidoreductase; Validated; Region: PRK05257 456481002804 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 456481002805 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 456481002806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 456481002807 putative active site [active] 456481002808 putative metal binding site [ion binding]; other site 456481002809 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 456481002810 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481002811 dimer interface [polypeptide binding]; other site 456481002812 putative CheW interface [polypeptide binding]; other site 456481002813 PAS domain; Region: PAS_9; pfam13426 456481002814 PAS domain S-box; Region: sensory_box; TIGR00229 456481002815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481002816 putative active site [active] 456481002817 heme pocket [chemical binding]; other site 456481002818 PAS fold; Region: PAS_4; pfam08448 456481002819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481002820 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 456481002821 dimer interface [polypeptide binding]; other site 456481002822 phosphorylation site [posttranslational modification] 456481002823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002824 ATP binding site [chemical binding]; other site 456481002825 Mg2+ binding site [ion binding]; other site 456481002826 G-X-G motif; other site 456481002827 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481002828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481002829 active site 456481002830 phosphorylation site [posttranslational modification] 456481002831 intermolecular recognition site; other site 456481002832 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481002833 cyclase homology domain; Region: CHD; cd07302 456481002834 nucleotidyl binding site; other site 456481002835 metal binding site [ion binding]; metal-binding site 456481002836 dimer interface [polypeptide binding]; other site 456481002837 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481002838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481002839 metal binding site [ion binding]; metal-binding site 456481002840 active site 456481002841 I-site; other site 456481002842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 456481002843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481002844 dimer interface [polypeptide binding]; other site 456481002845 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 456481002846 putative CheW interface [polypeptide binding]; other site 456481002847 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481002848 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481002849 Histidine kinase; Region: His_kinase; pfam06580 456481002850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 456481002851 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 456481002852 dimerization interface [polypeptide binding]; other site 456481002853 LytTr DNA-binding domain; Region: LytTR; smart00850 456481002854 Predicted membrane protein [Function unknown]; Region: COG4270 456481002855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 456481002856 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 456481002857 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 456481002858 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 456481002859 putative hydrophobic ligand binding site [chemical binding]; other site 456481002860 Putative Ig domain; Region: He_PIG; pfam05345 456481002861 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 456481002862 putative active site [active] 456481002863 putative metal binding site [ion binding]; other site 456481002864 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 456481002865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481002866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481002867 Repair protein; Region: Repair_PSII; pfam04536 456481002868 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 456481002869 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 456481002870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 456481002871 active site 456481002872 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 456481002873 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 456481002874 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 456481002875 active site 456481002876 catalytic residues [active] 456481002877 metal binding site [ion binding]; metal-binding site 456481002878 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 456481002879 Na binding site [ion binding]; other site 456481002880 FOG: CBS domain [General function prediction only]; Region: COG0517 456481002881 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 456481002882 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 456481002883 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481002884 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 456481002885 acyl-activating enzyme (AAE) consensus motif; other site 456481002886 acyl-activating enzyme (AAE) consensus motif; other site 456481002887 putative AMP binding site [chemical binding]; other site 456481002888 putative active site [active] 456481002889 putative CoA binding site [chemical binding]; other site 456481002890 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481002891 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481002892 active site 456481002893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 456481002894 PAS fold; Region: PAS_3; pfam08447 456481002895 putative active site [active] 456481002896 heme pocket [chemical binding]; other site 456481002897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 456481002898 Histidine kinase; Region: HisKA_2; pfam07568 456481002899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481002900 ATP binding site [chemical binding]; other site 456481002901 Mg2+ binding site [ion binding]; other site 456481002902 G-X-G motif; other site 456481002903 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 456481002904 dimer interaction site [polypeptide binding]; other site 456481002905 substrate-binding tunnel; other site 456481002906 active site 456481002907 catalytic site [active] 456481002908 substrate binding site [chemical binding]; other site 456481002909 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 456481002910 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 456481002911 active site 456481002912 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 456481002913 Acyltransferase family; Region: Acyl_transf_3; pfam01757 456481002914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481002915 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 456481002916 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481002917 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481002918 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481002919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 456481002920 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 456481002921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481002922 S-adenosylmethionine binding site [chemical binding]; other site 456481002923 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 456481002924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481002925 non-specific DNA binding site [nucleotide binding]; other site 456481002926 salt bridge; other site 456481002927 sequence-specific DNA binding site [nucleotide binding]; other site 456481002928 Cupin domain; Region: Cupin_2; pfam07883 456481002929 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 456481002930 putative SAM binding site [chemical binding]; other site 456481002931 homodimer interface [polypeptide binding]; other site 456481002932 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 456481002933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481002934 motif II; other site 456481002935 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481002936 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481002937 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 456481002938 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 456481002939 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 456481002940 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 456481002941 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 456481002942 Competence protein; Region: Competence; pfam03772 456481002943 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 456481002944 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 456481002945 active site 456481002946 HIGH motif; other site 456481002947 dimer interface [polypeptide binding]; other site 456481002948 KMSKS motif; other site 456481002949 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 456481002950 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 456481002951 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 456481002952 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 456481002953 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 456481002954 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 456481002955 Ligand binding site [chemical binding]; other site 456481002956 Electron transfer flavoprotein domain; Region: ETF; pfam01012 456481002957 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481002958 cyclase homology domain; Region: CHD; cd07302 456481002959 nucleotidyl binding site; other site 456481002960 metal binding site [ion binding]; metal-binding site 456481002961 dimer interface [polypeptide binding]; other site 456481002962 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 456481002963 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 456481002964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481002965 active site 456481002966 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 456481002967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481002968 homoserine kinase; Provisional; Region: PRK01212 456481002969 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 456481002970 Thioredoxin; Region: Thioredoxin_4; pfam13462 456481002971 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 456481002972 malate dehydrogenase; Provisional; Region: PRK05442 456481002973 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 456481002974 NAD(P) binding site [chemical binding]; other site 456481002975 dimer interface [polypeptide binding]; other site 456481002976 malate binding site [chemical binding]; other site 456481002977 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 456481002978 MarR family; Region: MarR_2; pfam12802 456481002979 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 456481002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481002981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481002982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481002983 ligand binding site [chemical binding]; other site 456481002984 flexible hinge region; other site 456481002985 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481002986 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481002987 ligand binding site [chemical binding]; other site 456481002988 flexible hinge region; other site 456481002989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481002990 binding surface 456481002991 TPR motif; other site 456481002992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481002993 binding surface 456481002994 TPR motif; other site 456481002995 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 456481002996 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 456481002997 active site 456481002998 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481002999 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481003000 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481003001 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 456481003002 elongation factor G; Reviewed; Region: PRK12740 456481003003 G1 box; other site 456481003004 putative GEF interaction site [polypeptide binding]; other site 456481003005 GTP/Mg2+ binding site [chemical binding]; other site 456481003006 Switch I region; other site 456481003007 G2 box; other site 456481003008 G3 box; other site 456481003009 Switch II region; other site 456481003010 G4 box; other site 456481003011 G5 box; other site 456481003012 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 456481003013 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 456481003014 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 456481003015 Cation transport protein; Region: TrkH; cl17365 456481003016 Cation transport protein; Region: TrkH; cl17365 456481003017 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 456481003018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 456481003019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 456481003020 catalytic residues [active] 456481003021 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 456481003022 active site 456481003023 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 456481003024 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 456481003025 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 456481003026 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 456481003027 dimer interface [polypeptide binding]; other site 456481003028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481003029 catalytic residue [active] 456481003030 DNA topoisomerase I; Validated; Region: PRK05582 456481003031 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 456481003032 active site 456481003033 metal binding site [ion binding]; metal-binding site 456481003034 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 456481003035 domain I; other site 456481003036 DNA binding groove [nucleotide binding] 456481003037 phosphate binding site [ion binding]; other site 456481003038 domain II; other site 456481003039 domain III; other site 456481003040 nucleotide binding site [chemical binding]; other site 456481003041 catalytic site [active] 456481003042 domain IV; other site 456481003043 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 456481003044 Ferrochelatase; Region: Ferrochelatase; pfam00762 456481003045 C-terminal domain interface [polypeptide binding]; other site 456481003046 active site 456481003047 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 456481003048 active site 456481003049 N-terminal domain interface [polypeptide binding]; other site 456481003050 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 456481003051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481003052 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 456481003053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481003054 FeS/SAM binding site; other site 456481003055 HemN C-terminal domain; Region: HemN_C; pfam06969 456481003056 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 456481003057 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 456481003058 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 456481003059 inhibitor-cofactor binding pocket; inhibition site 456481003060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481003061 catalytic residue [active] 456481003062 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 456481003063 dimer interface [polypeptide binding]; other site 456481003064 active site 456481003065 Schiff base residues; other site 456481003066 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 456481003067 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 456481003068 domain interfaces; other site 456481003069 active site 456481003070 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 456481003071 NAD(P) binding pocket [chemical binding]; other site 456481003072 methionine sulfoxide reductase B; Provisional; Region: PRK00222 456481003073 SelR domain; Region: SelR; pfam01641 456481003074 Nuclease-related domain; Region: NERD; pfam08378 456481003075 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 456481003076 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 456481003077 Walker A motif; other site 456481003078 ATP binding site [chemical binding]; other site 456481003079 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 456481003080 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 456481003081 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 456481003082 active site 456481003083 SAM binding site [chemical binding]; other site 456481003084 homodimer interface [polypeptide binding]; other site 456481003085 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 456481003086 Flavodoxin; Region: Flavodoxin_1; pfam00258 456481003087 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 456481003088 FAD binding pocket [chemical binding]; other site 456481003089 FAD binding motif [chemical binding]; other site 456481003090 catalytic residues [active] 456481003091 NAD binding pocket [chemical binding]; other site 456481003092 phosphate binding motif [ion binding]; other site 456481003093 beta-alpha-beta structure motif; other site 456481003094 sulfite reductase subunit beta; Provisional; Region: PRK13504 456481003095 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 456481003096 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 456481003097 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 456481003098 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 456481003099 CysD dimerization site [polypeptide binding]; other site 456481003100 G1 box; other site 456481003101 putative GEF interaction site [polypeptide binding]; other site 456481003102 GTP/Mg2+ binding site [chemical binding]; other site 456481003103 Switch I region; other site 456481003104 G2 box; other site 456481003105 G3 box; other site 456481003106 Switch II region; other site 456481003107 G4 box; other site 456481003108 G5 box; other site 456481003109 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 456481003110 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 456481003111 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 456481003112 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 456481003113 Active Sites [active] 456481003114 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 456481003115 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 456481003116 Active Sites [active] 456481003117 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 456481003118 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 456481003119 Walker A/P-loop; other site 456481003120 ATP binding site [chemical binding]; other site 456481003121 Q-loop/lid; other site 456481003122 ABC transporter signature motif; other site 456481003123 Walker B; other site 456481003124 D-loop; other site 456481003125 H-loop/switch region; other site 456481003126 TOBE-like domain; Region: TOBE_3; pfam12857 456481003127 sulfate transport protein; Provisional; Region: cysT; CHL00187 456481003128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 456481003129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481003130 dimer interface [polypeptide binding]; other site 456481003131 conserved gate region; other site 456481003132 putative PBP binding loops; other site 456481003133 ABC-ATPase subunit interface; other site 456481003134 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 456481003135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481003136 dimer interface [polypeptide binding]; other site 456481003137 conserved gate region; other site 456481003138 putative PBP binding loops; other site 456481003139 ABC-ATPase subunit interface; other site 456481003140 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 456481003141 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 456481003142 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 456481003143 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 456481003144 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 456481003145 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 456481003146 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 456481003147 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 456481003148 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 456481003149 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481003150 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481003151 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481003152 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481003153 Zn2+ binding site [ion binding]; other site 456481003154 Mg2+ binding site [ion binding]; other site 456481003155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481003156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481003157 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 456481003158 NAD(P) binding site [chemical binding]; other site 456481003159 active site 456481003160 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 456481003161 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 456481003162 NAD(P) binding pocket [chemical binding]; other site 456481003163 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 456481003164 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481003165 anti sigma factor interaction site; other site 456481003166 regulatory phosphorylation site [posttranslational modification]; other site 456481003167 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 456481003168 active site 456481003169 ribulose/triose binding site [chemical binding]; other site 456481003170 phosphate binding site [ion binding]; other site 456481003171 substrate (anthranilate) binding pocket [chemical binding]; other site 456481003172 product (indole) binding pocket [chemical binding]; other site 456481003173 MASE1; Region: MASE1; cl17823 456481003174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481003175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481003176 dimer interface [polypeptide binding]; other site 456481003177 phosphorylation site [posttranslational modification] 456481003178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481003179 ATP binding site [chemical binding]; other site 456481003180 Mg2+ binding site [ion binding]; other site 456481003181 G-X-G motif; other site 456481003182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481003183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481003184 ATP binding site [chemical binding]; other site 456481003185 Mg2+ binding site [ion binding]; other site 456481003186 G-X-G motif; other site 456481003187 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 456481003188 inhibitor binding site; inhibition site 456481003189 catalytic motif [active] 456481003190 Catalytic residue [active] 456481003191 Active site flap [active] 456481003192 integron integrase; Region: integrase_gron; TIGR02249 456481003193 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 456481003194 active site 456481003195 DNA binding site [nucleotide binding] 456481003196 Int/Topo IB signature motif; other site 456481003197 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003198 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481003199 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003200 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 456481003201 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 456481003202 Cytochrome c; Region: Cytochrom_C; pfam00034 456481003203 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 456481003204 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 456481003205 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 456481003206 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 456481003207 RibD C-terminal domain; Region: RibD_C; cl17279 456481003208 Transposase; Region: HTH_Tnp_1; pfam01527 456481003209 Winged helix-turn helix; Region: HTH_29; pfam13551 456481003210 HTH-like domain; Region: HTH_21; pfam13276 456481003211 Integrase core domain; Region: rve; pfam00665 456481003212 Integrase core domain; Region: rve_3; pfam13683 456481003213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481003214 PAS domain; Region: PAS_9; pfam13426 456481003215 putative active site [active] 456481003216 heme pocket [chemical binding]; other site 456481003217 Histidine kinase; Region: HisKA_2; pfam07568 456481003218 PAS domain; Region: PAS; smart00091 456481003219 PAS fold; Region: PAS_3; pfam08447 456481003220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481003221 heme pocket [chemical binding]; other site 456481003222 putative active site [active] 456481003223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481003224 putative active site [active] 456481003225 heme pocket [chemical binding]; other site 456481003226 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481003227 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481003228 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481003229 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481003230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481003231 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 456481003232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 456481003233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 456481003234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 456481003235 dimerization interface [polypeptide binding]; other site 456481003236 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 456481003237 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 456481003238 substrate binding site [chemical binding]; other site 456481003239 ligand binding site [chemical binding]; other site 456481003240 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 456481003241 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 456481003242 hypothetical protein; Provisional; Region: PRK14812 456481003243 substrate binding site [chemical binding]; other site 456481003244 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481003245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481003246 dimer interface [polypeptide binding]; other site 456481003247 putative CheW interface [polypeptide binding]; other site 456481003248 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481003250 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003252 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481003253 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003254 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481003255 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003256 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481003258 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 456481003259 YCII-related domain; Region: YCII; cl00999 456481003260 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 456481003261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481003262 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 456481003263 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 456481003264 NADP+ binding site [chemical binding]; other site 456481003265 RibD C-terminal domain; Region: RibD_C; cl17279 456481003266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481003267 dimerization interface [polypeptide binding]; other site 456481003268 putative DNA binding site [nucleotide binding]; other site 456481003269 putative Zn2+ binding site [ion binding]; other site 456481003270 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 456481003271 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 456481003272 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 456481003273 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 456481003274 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 456481003275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481003276 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481003277 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481003278 dimer interface [polypeptide binding]; other site 456481003279 putative CheW interface [polypeptide binding]; other site 456481003280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481003281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481003282 active site 456481003283 Amidohydrolase; Region: Amidohydro_2; pfam04909 456481003284 active site 456481003285 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 456481003286 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 456481003287 intersubunit interface [polypeptide binding]; other site 456481003288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481003289 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481003290 Walker A/P-loop; other site 456481003291 ATP binding site [chemical binding]; other site 456481003292 Q-loop/lid; other site 456481003293 ABC transporter signature motif; other site 456481003294 Walker B; other site 456481003295 D-loop; other site 456481003296 H-loop/switch region; other site 456481003297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 456481003298 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 456481003299 Methyltransferase domain; Region: Methyltransf_31; pfam13847 456481003300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481003301 S-adenosylmethionine binding site [chemical binding]; other site 456481003302 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 456481003303 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 456481003304 TMP-binding site; other site 456481003305 ATP-binding site [chemical binding]; other site 456481003306 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481003307 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 456481003308 B12 binding domain; Region: B12-binding; pfam02310 456481003309 B12 binding site [chemical binding]; other site 456481003310 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 456481003311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481003312 FeS/SAM binding site; other site 456481003313 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 456481003314 inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314 456481003315 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 456481003316 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 456481003317 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 456481003318 active site 456481003319 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 456481003320 RNA methyltransferase, RsmE family; Region: TIGR00046 456481003321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481003322 Bacterial Ig-like domain; Region: Big_5; pfam13205 456481003323 MG2 domain; Region: A2M_N; pfam01835 456481003324 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 456481003325 Alpha-2-macroglobulin family; Region: A2M; pfam00207 456481003326 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 456481003327 Sulfatase; Region: Sulfatase; cl17466 456481003328 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 456481003329 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 456481003330 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 456481003331 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 456481003332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 456481003333 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481003334 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 456481003335 IMP binding site; other site 456481003336 dimer interface [polypeptide binding]; other site 456481003337 interdomain contacts; other site 456481003338 partial ornithine binding site; other site 456481003339 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 456481003340 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 456481003341 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 456481003342 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 456481003343 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 456481003344 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 456481003345 minor groove reading motif; other site 456481003346 helix-hairpin-helix signature motif; other site 456481003347 substrate binding pocket [chemical binding]; other site 456481003348 active site 456481003349 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 456481003350 HAMP domain; Region: HAMP; pfam00672 456481003351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481003352 dimer interface [polypeptide binding]; other site 456481003353 phosphorylation site [posttranslational modification] 456481003354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481003355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481003356 ATP binding site [chemical binding]; other site 456481003357 Mg2+ binding site [ion binding]; other site 456481003358 G-X-G motif; other site 456481003359 Response regulator receiver domain; Region: Response_reg; pfam00072 456481003360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481003361 active site 456481003362 phosphorylation site [posttranslational modification] 456481003363 intermolecular recognition site; other site 456481003364 dimerization interface [polypeptide binding]; other site 456481003365 Smr domain; Region: Smr; pfam01713 456481003366 (R)-citramalate synthase; Provisional; Region: PRK09389 456481003367 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 456481003368 active site 456481003369 catalytic residues [active] 456481003370 metal binding site [ion binding]; metal-binding site 456481003371 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 456481003372 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 456481003373 putative active site [active] 456481003374 catalytic residue [active] 456481003375 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 456481003376 recombination factor protein RarA; Reviewed; Region: PRK13342 456481003377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481003378 Walker A motif; other site 456481003379 ATP binding site [chemical binding]; other site 456481003380 Walker B motif; other site 456481003381 arginine finger; other site 456481003382 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 456481003383 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 456481003384 NADH dehydrogenase subunit B; Provisional; Region: PRK14814 456481003385 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 456481003386 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 456481003387 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 456481003388 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 456481003389 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 456481003390 putative dimer interface [polypeptide binding]; other site 456481003391 [2Fe-2S] cluster binding site [ion binding]; other site 456481003392 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 456481003393 SLBB domain; Region: SLBB; pfam10531 456481003394 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 456481003395 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 456481003396 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 456481003397 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 456481003398 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 456481003399 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 456481003400 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 456481003401 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 456481003402 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 456481003403 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 456481003404 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 456481003405 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 456481003406 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 456481003407 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 456481003408 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 456481003409 Cupin domain; Region: Cupin_2; cl17218 456481003410 DHH family; Region: DHH; pfam01368 456481003411 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 456481003412 DHHA1 domain; Region: DHHA1; pfam02272 456481003413 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 456481003414 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 456481003415 inorganic pyrophosphatase; Provisional; Region: PRK00642 456481003416 dimer interface [polypeptide binding]; other site 456481003417 substrate binding site [chemical binding]; other site 456481003418 metal binding sites [ion binding]; metal-binding site 456481003419 Outer membrane efflux protein; Region: OEP; pfam02321 456481003420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 456481003421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 456481003422 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481003423 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 456481003424 LexA repressor; Validated; Region: PRK00215 456481003425 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 456481003426 Catalytic site [active] 456481003427 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 456481003428 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 456481003429 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 456481003430 protein binding site [polypeptide binding]; other site 456481003431 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 456481003432 Catalytic dyad [active] 456481003433 UGMP family protein; Validated; Region: PRK09604 456481003434 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 456481003435 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 456481003436 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 456481003437 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481003438 anti sigma factor interaction site; other site 456481003439 regulatory phosphorylation site [posttranslational modification]; other site 456481003440 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 456481003441 glycerol kinase; Provisional; Region: glpK; PRK00047 456481003442 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 456481003443 N- and C-terminal domain interface [polypeptide binding]; other site 456481003444 active site 456481003445 MgATP binding site [chemical binding]; other site 456481003446 catalytic site [active] 456481003447 metal binding site [ion binding]; metal-binding site 456481003448 glycerol binding site [chemical binding]; other site 456481003449 homotetramer interface [polypeptide binding]; other site 456481003450 homodimer interface [polypeptide binding]; other site 456481003451 FBP binding site [chemical binding]; other site 456481003452 protein IIAGlc interface [polypeptide binding]; other site 456481003453 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 456481003454 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 456481003455 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 456481003456 active site 456481003457 NAD binding site [chemical binding]; other site 456481003458 metal binding site [ion binding]; metal-binding site 456481003459 seryl-tRNA synthetase; Provisional; Region: PRK05431 456481003460 Predicted methyltransferases [General function prediction only]; Region: COG0313 456481003461 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 456481003462 putative SAM binding site [chemical binding]; other site 456481003463 putative homodimer interface [polypeptide binding]; other site 456481003464 NAD synthetase; Provisional; Region: PRK13981 456481003465 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 456481003466 multimer interface [polypeptide binding]; other site 456481003467 active site 456481003468 catalytic triad [active] 456481003469 protein interface 1 [polypeptide binding]; other site 456481003470 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 456481003471 Ligand Binding Site [chemical binding]; other site 456481003472 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 456481003473 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 456481003474 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 456481003475 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 456481003476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 456481003477 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 456481003478 catalytic residue [active] 456481003479 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 456481003480 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 456481003481 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481003482 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481003483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481003484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481003485 metal binding site [ion binding]; metal-binding site 456481003486 active site 456481003487 I-site; other site 456481003488 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 456481003489 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 456481003490 Ligand Binding Site [chemical binding]; other site 456481003491 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 456481003492 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 456481003493 active site 456481003494 substrate binding site [chemical binding]; other site 456481003495 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 456481003496 FMN binding site [chemical binding]; other site 456481003497 putative catalytic residues [active] 456481003498 PilZ domain; Region: PilZ; pfam07238 456481003499 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 456481003500 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 456481003501 active site 456481003502 DNA methylase; Region: N6_N4_Mtase; cl17433 456481003503 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 456481003504 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 456481003505 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 456481003506 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 456481003507 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 456481003508 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 456481003509 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 456481003510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 456481003511 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 456481003512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 456481003513 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 456481003514 active site 456481003515 metal binding site [ion binding]; metal-binding site 456481003516 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 456481003517 CoenzymeA binding site [chemical binding]; other site 456481003518 subunit interaction site [polypeptide binding]; other site 456481003519 PHB binding site; other site 456481003520 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 456481003521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481003522 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481003523 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 456481003524 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 456481003525 dimer interface [polypeptide binding]; other site 456481003526 decamer (pentamer of dimers) interface [polypeptide binding]; other site 456481003527 catalytic triad [active] 456481003528 peroxidatic and resolving cysteines [active] 456481003529 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 456481003530 FeS assembly protein SufB; Region: sufB; TIGR01980 456481003531 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 456481003532 Sulfatase; Region: Sulfatase; pfam00884 456481003533 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 456481003534 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 456481003535 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14465 456481003536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481003537 FeS/SAM binding site; other site 456481003538 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 456481003539 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 456481003540 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 456481003541 heme-binding residues [chemical binding]; other site 456481003542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 456481003543 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 456481003544 molybdopterin cofactor binding site; other site 456481003545 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 456481003546 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 456481003547 4Fe-4S binding domain; Region: Fer4; cl02805 456481003548 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 456481003549 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 456481003550 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 456481003551 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 456481003552 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 456481003553 MarR family; Region: MarR_2; pfam12802 456481003554 cyclase homology domain; Region: CHD; cd07302 456481003555 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481003556 nucleotidyl binding site; other site 456481003557 metal binding site [ion binding]; metal-binding site 456481003558 dimer interface [polypeptide binding]; other site 456481003559 AAA domain; Region: AAA_11; pfam13086 456481003560 Part of AAA domain; Region: AAA_19; pfam13245 456481003561 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 456481003562 AAA domain; Region: AAA_12; pfam13087 456481003563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481003564 binding surface 456481003565 TPR motif; other site 456481003566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481003567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481003568 binding surface 456481003569 TPR motif; other site 456481003570 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 456481003571 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 456481003572 enoyl-CoA hydratase; Provisional; Region: PRK06142 456481003573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481003574 substrate binding site [chemical binding]; other site 456481003575 oxyanion hole (OAH) forming residues; other site 456481003576 trimer interface [polypeptide binding]; other site 456481003577 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 456481003578 DoxX; Region: DoxX; pfam07681 456481003579 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481003580 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481003581 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 456481003582 active site 456481003583 NTP binding site [chemical binding]; other site 456481003584 metal binding triad [ion binding]; metal-binding site 456481003585 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 456481003586 thiamine monophosphate kinase; Provisional; Region: PRK05731 456481003587 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 456481003588 ATP binding site [chemical binding]; other site 456481003589 dimerization interface [polypeptide binding]; other site 456481003590 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 456481003591 23S rRNA interface [nucleotide binding]; other site 456481003592 L3 interface [polypeptide binding]; other site 456481003593 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 456481003594 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 456481003595 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 456481003596 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 456481003597 motif 1; other site 456481003598 active site 456481003599 motif 2; other site 456481003600 motif 3; other site 456481003601 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 456481003602 DHHA1 domain; Region: DHHA1; pfam02272 456481003603 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 456481003604 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 456481003605 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 456481003606 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 456481003607 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 456481003608 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 456481003609 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 456481003610 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 456481003611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481003612 non-specific DNA binding site [nucleotide binding]; other site 456481003613 salt bridge; other site 456481003614 sequence-specific DNA binding site [nucleotide binding]; other site 456481003615 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 456481003616 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 456481003617 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 456481003618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481003619 FeS/SAM binding site; other site 456481003620 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 456481003621 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 456481003622 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 456481003623 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 456481003624 Preprotein translocase subunit; Region: YajC; pfam02699 456481003625 protein-export membrane protein SecD; Region: secD; TIGR01129 456481003626 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 456481003627 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 456481003628 Protein export membrane protein; Region: SecD_SecF; cl14618 456481003629 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 456481003630 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 456481003631 catalytic motif [active] 456481003632 Zn binding site [ion binding]; other site 456481003633 RibD C-terminal domain; Region: RibD_C; cl17279 456481003634 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 456481003635 Lumazine binding domain; Region: Lum_binding; pfam00677 456481003636 Lumazine binding domain; Region: Lum_binding; pfam00677 456481003637 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481003638 anti sigma factor interaction site; other site 456481003639 regulatory phosphorylation site [posttranslational modification]; other site 456481003640 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 456481003641 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 456481003642 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 456481003643 dimerization interface [polypeptide binding]; other site 456481003644 active site 456481003645 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 456481003646 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 456481003647 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 456481003648 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 456481003649 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 456481003650 aspartate aminotransferase; Provisional; Region: PRK05764 456481003651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481003652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481003653 homodimer interface [polypeptide binding]; other site 456481003654 catalytic residue [active] 456481003655 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 456481003656 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 456481003657 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 456481003658 SmpB-tmRNA interface; other site 456481003659 GTP-binding protein Der; Reviewed; Region: PRK00093 456481003660 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 456481003661 G1 box; other site 456481003662 GTP/Mg2+ binding site [chemical binding]; other site 456481003663 G2 box; other site 456481003664 Switch I region; other site 456481003665 G3 box; other site 456481003666 Switch II region; other site 456481003667 G4 box; other site 456481003668 G5 box; other site 456481003669 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 456481003670 G1 box; other site 456481003671 GTP/Mg2+ binding site [chemical binding]; other site 456481003672 Switch I region; other site 456481003673 G2 box; other site 456481003674 G3 box; other site 456481003675 Switch II region; other site 456481003676 G4 box; other site 456481003677 G5 box; other site 456481003678 membrane protein; Provisional; Region: PRK14409 456481003679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 456481003680 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 456481003681 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 456481003682 Walker A/P-loop; other site 456481003683 ATP binding site [chemical binding]; other site 456481003684 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 456481003685 ABC transporter signature motif; other site 456481003686 Walker B; other site 456481003687 D-loop; other site 456481003688 H-loop/switch region; other site 456481003689 glutamine synthetase, type I; Region: GlnA; TIGR00653 456481003690 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 456481003691 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 456481003692 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481003693 GAF domain; Region: GAF; pfam01590 456481003694 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481003695 Protein of unknown function (DUF328); Region: DUF328; cl01143 456481003696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 456481003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481003698 active site 456481003699 phosphorylation site [posttranslational modification] 456481003700 intermolecular recognition site; other site 456481003701 dimerization interface [polypeptide binding]; other site 456481003702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 456481003703 DNA binding site [nucleotide binding] 456481003704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481003705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481003706 dimer interface [polypeptide binding]; other site 456481003707 phosphorylation site [posttranslational modification] 456481003708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481003709 ATP binding site [chemical binding]; other site 456481003710 Mg2+ binding site [ion binding]; other site 456481003711 G-X-G motif; other site 456481003712 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 456481003713 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 456481003714 putative active site; other site 456481003715 catalytic residue [active] 456481003716 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 456481003717 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 456481003718 Protein of unknown function (DUF962); Region: DUF962; cl01879 456481003719 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 456481003720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481003721 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 456481003722 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 456481003723 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 456481003724 LysM domain; Region: LysM; pfam01476 456481003725 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481003726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481003727 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481003728 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 456481003729 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 456481003730 Transglycosylase; Region: Transgly; pfam00912 456481003731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 456481003732 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 456481003733 diaminopimelate decarboxylase; Provisional; Region: PRK11165 456481003734 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 456481003735 active site 456481003736 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 456481003737 substrate binding site [chemical binding]; other site 456481003738 catalytic residues [active] 456481003739 dimer interface [polypeptide binding]; other site 456481003740 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 456481003741 substrate binding site; other site 456481003742 dimer interface; other site 456481003743 PilZ domain; Region: PilZ; pfam07238 456481003744 PilZ domain; Region: PilZ; pfam07238 456481003745 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481003746 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481003747 ligand binding site [chemical binding]; other site 456481003748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481003749 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481003750 ligand binding site [chemical binding]; other site 456481003751 flexible hinge region; other site 456481003752 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 456481003753 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481003754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481003755 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 456481003756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481003757 Family description; Region: VCBS; pfam13517 456481003758 FG-GAP repeat; Region: FG-GAP; pfam01839 456481003759 Family description; Region: VCBS; pfam13517 456481003760 Family description; Region: VCBS; pfam13517 456481003761 FG-GAP repeat; Region: FG-GAP; cl15299 456481003762 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 456481003763 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 456481003764 Sporulation related domain; Region: SPOR; pfam05036 456481003765 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 456481003766 dephospho-CoA kinase; Region: TIGR00152 456481003767 CoA-binding site [chemical binding]; other site 456481003768 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481003769 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 456481003770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 456481003771 DNA-binding site [nucleotide binding]; DNA binding site 456481003772 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481003773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481003774 homodimer interface [polypeptide binding]; other site 456481003775 catalytic residue [active] 456481003776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481003777 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 456481003778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481003779 homodimer interface [polypeptide binding]; other site 456481003780 catalytic residue [active] 456481003781 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481003782 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481003783 FecR protein; Region: FecR; pfam04773 456481003784 lipoyl synthase; Provisional; Region: PRK05481 456481003785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481003786 FeS/SAM binding site; other site 456481003787 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 456481003788 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 456481003789 RNA binding surface [nucleotide binding]; other site 456481003790 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 456481003791 active site 456481003792 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481003793 HPP family; Region: HPP; pfam04982 456481003794 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 456481003795 active site 456481003796 intersubunit interactions; other site 456481003797 catalytic residue [active] 456481003798 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 456481003799 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 456481003800 purine monophosphate binding site [chemical binding]; other site 456481003801 dimer interface [polypeptide binding]; other site 456481003802 putative catalytic residues [active] 456481003803 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 456481003804 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 456481003805 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 456481003806 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 456481003807 active site 456481003808 substrate binding site [chemical binding]; other site 456481003809 cosubstrate binding site; other site 456481003810 catalytic site [active] 456481003811 Flagellar protein FliS; Region: FliS; cl00654 456481003812 DctM-like transporters; Region: DctM; pfam06808 456481003813 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 456481003814 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 456481003815 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 456481003816 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 456481003817 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 456481003818 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 456481003819 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 456481003820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481003821 Zn2+ binding site [ion binding]; other site 456481003822 Mg2+ binding site [ion binding]; other site 456481003823 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 456481003824 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 456481003825 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 456481003826 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 456481003827 N-terminal domain interface [polypeptide binding]; other site 456481003828 dimer interface [polypeptide binding]; other site 456481003829 substrate binding pocket (H-site) [chemical binding]; other site 456481003830 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 456481003831 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 456481003832 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 456481003833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481003834 dimer interface [polypeptide binding]; other site 456481003835 phosphorylation site [posttranslational modification] 456481003836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481003837 ATP binding site [chemical binding]; other site 456481003838 Mg2+ binding site [ion binding]; other site 456481003839 G-X-G motif; other site 456481003840 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 456481003841 PAS domain S-box; Region: sensory_box; TIGR00229 456481003842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481003843 putative active site [active] 456481003844 heme pocket [chemical binding]; other site 456481003845 PAS domain; Region: PAS_9; pfam13426 456481003846 PAS fold; Region: PAS_4; pfam08448 456481003847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481003848 dimer interface [polypeptide binding]; other site 456481003849 phosphorylation site [posttranslational modification] 456481003850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481003851 ATP binding site [chemical binding]; other site 456481003852 Mg2+ binding site [ion binding]; other site 456481003853 G-X-G motif; other site 456481003854 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481003855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481003856 active site 456481003857 phosphorylation site [posttranslational modification] 456481003858 intermolecular recognition site; other site 456481003859 dimerization interface [polypeptide binding]; other site 456481003860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481003861 dimerization interface [polypeptide binding]; other site 456481003862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481003863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481003864 dimer interface [polypeptide binding]; other site 456481003865 putative CheW interface [polypeptide binding]; other site 456481003866 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481003867 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481003868 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481003869 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 456481003870 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 456481003871 Active site serine [active] 456481003872 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 456481003873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481003874 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 456481003875 dimer interface [polypeptide binding]; other site 456481003876 substrate binding site [chemical binding]; other site 456481003877 metal binding site [ion binding]; metal-binding site 456481003878 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 456481003879 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 456481003880 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 456481003881 nucleotide binding site/active site [active] 456481003882 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 456481003883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 456481003884 nucleotide binding site [chemical binding]; other site 456481003885 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481003886 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481003887 Walker A/P-loop; other site 456481003888 ATP binding site [chemical binding]; other site 456481003889 Q-loop/lid; other site 456481003890 ABC transporter signature motif; other site 456481003891 Walker B; other site 456481003892 D-loop; other site 456481003893 H-loop/switch region; other site 456481003894 Restriction endonuclease; Region: Mrr_cat; pfam04471 456481003895 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 456481003896 RuvA N terminal domain; Region: RuvA_N; pfam01330 456481003897 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481003898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481003899 ligand binding site [chemical binding]; other site 456481003900 flexible hinge region; other site 456481003901 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 456481003902 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 456481003903 nucleophile elbow; other site 456481003904 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 456481003905 NlpC/P60 family; Region: NLPC_P60; pfam00877 456481003906 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 456481003907 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 456481003908 active site 456481003909 nucleophile elbow; other site 456481003910 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 456481003911 Peptidase family M48; Region: Peptidase_M48; cl12018 456481003912 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 456481003913 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481003914 cyclase homology domain; Region: CHD; cd07302 456481003915 nucleotidyl binding site; other site 456481003916 metal binding site [ion binding]; metal-binding site 456481003917 dimer interface [polypeptide binding]; other site 456481003918 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 456481003919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 456481003920 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481003921 dimer interface [polypeptide binding]; other site 456481003922 putative CheW interface [polypeptide binding]; other site 456481003923 Surface antigen; Region: Bac_surface_Ag; pfam01103 456481003924 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 456481003925 HIT family signature motif; other site 456481003926 catalytic residue [active] 456481003927 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 456481003928 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 456481003929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 456481003930 MarR family; Region: MarR_2; pfam12802 456481003931 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 456481003932 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 456481003933 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 456481003934 putative substrate binding site [chemical binding]; other site 456481003935 putative ATP binding site [chemical binding]; other site 456481003936 hypothetical protein; Provisional; Region: PRK14635 456481003937 ribosome maturation protein RimP; Reviewed; Region: PRK00092 456481003938 heptamer interface [polypeptide binding]; other site 456481003939 Sm1 motif; other site 456481003940 hexamer interface [polypeptide binding]; other site 456481003941 RNA binding site [nucleotide binding]; other site 456481003942 Sm2 motif; other site 456481003943 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 456481003944 NusA N-terminal domain; Region: NusA_N; pfam08529 456481003945 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 456481003946 RNA binding site [nucleotide binding]; other site 456481003947 homodimer interface [polypeptide binding]; other site 456481003948 NusA-like KH domain; Region: KH_5; pfam13184 456481003949 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 456481003950 G-X-X-G motif; other site 456481003951 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 456481003952 translation initiation factor IF-2; Region: IF-2; TIGR00487 456481003953 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 456481003954 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 456481003955 G1 box; other site 456481003956 putative GEF interaction site [polypeptide binding]; other site 456481003957 GTP/Mg2+ binding site [chemical binding]; other site 456481003958 Switch I region; other site 456481003959 G2 box; other site 456481003960 G3 box; other site 456481003961 Switch II region; other site 456481003962 G4 box; other site 456481003963 G5 box; other site 456481003964 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 456481003965 Translation-initiation factor 2; Region: IF-2; pfam11987 456481003966 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 456481003967 Ribosome-binding factor A; Region: RBFA; pfam02033 456481003968 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 456481003969 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 456481003970 active site 456481003971 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 456481003972 16S/18S rRNA binding site [nucleotide binding]; other site 456481003973 S13e-L30e interaction site [polypeptide binding]; other site 456481003974 25S rRNA binding site [nucleotide binding]; other site 456481003975 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 456481003976 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 456481003977 RNase E interface [polypeptide binding]; other site 456481003978 trimer interface [polypeptide binding]; other site 456481003979 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 456481003980 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 456481003981 RNase E interface [polypeptide binding]; other site 456481003982 trimer interface [polypeptide binding]; other site 456481003983 active site 456481003984 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 456481003985 putative nucleic acid binding region [nucleotide binding]; other site 456481003986 G-X-X-G motif; other site 456481003987 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 456481003988 RNA binding site [nucleotide binding]; other site 456481003989 domain interface; other site 456481003990 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 456481003991 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 456481003992 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 456481003993 Bacteriophage T4-like capsid assembly protein (Gp20); Region: Phage_T4_Gp20; pfam07230 456481003994 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 456481003995 trimer interface [polypeptide binding]; other site 456481003996 active site 456481003997 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 456481003998 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 456481003999 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 456481004000 Flagellar L-ring protein; Region: FlgH; cl17277 456481004001 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 456481004002 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 456481004003 Rod binding protein; Region: Rod-binding; pfam10135 456481004004 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 456481004005 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 456481004006 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481004007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481004008 S-adenosylmethionine binding site [chemical binding]; other site 456481004009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481004010 S-adenosylmethionine binding site [chemical binding]; other site 456481004011 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 456481004012 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 456481004013 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 456481004014 RNA recognition motif; Region: RRM; smart00360 456481004015 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 456481004016 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 456481004017 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 456481004018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 456481004019 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 456481004020 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 456481004021 putative NAD(P) binding site [chemical binding]; other site 456481004022 short chain dehydrogenase; Provisional; Region: PRK06179 456481004023 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 456481004024 NADP binding site [chemical binding]; other site 456481004025 active site 456481004026 steroid binding site; other site 456481004027 Predicted transcriptional regulators [Transcription]; Region: COG1733 456481004028 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 456481004029 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 456481004030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481004031 NAD(P) binding site [chemical binding]; other site 456481004032 active site 456481004033 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 456481004034 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 456481004035 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 456481004036 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 456481004037 PAS domain S-box; Region: sensory_box; TIGR00229 456481004038 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481004039 putative active site [active] 456481004040 heme pocket [chemical binding]; other site 456481004041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481004042 putative active site [active] 456481004043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481004044 heme pocket [chemical binding]; other site 456481004045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481004046 dimer interface [polypeptide binding]; other site 456481004047 phosphorylation site [posttranslational modification] 456481004048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481004049 ATP binding site [chemical binding]; other site 456481004050 Mg2+ binding site [ion binding]; other site 456481004051 G-X-G motif; other site 456481004052 Response regulator receiver domain; Region: Response_reg; pfam00072 456481004053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004054 active site 456481004055 phosphorylation site [posttranslational modification] 456481004056 intermolecular recognition site; other site 456481004057 dimerization interface [polypeptide binding]; other site 456481004058 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 456481004059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004060 active site 456481004061 phosphorylation site [posttranslational modification] 456481004062 intermolecular recognition site; other site 456481004063 dimerization interface [polypeptide binding]; other site 456481004064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481004065 Zn2+ binding site [ion binding]; other site 456481004066 Mg2+ binding site [ion binding]; other site 456481004067 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 456481004068 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 456481004069 intersubunit interface [polypeptide binding]; other site 456481004070 active site 456481004071 Zn2+ binding site [ion binding]; other site 456481004072 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004073 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 456481004074 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 456481004075 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 456481004076 FliG C-terminal domain; Region: FliG_C; pfam01706 456481004077 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 456481004078 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 456481004079 E3 interaction surface; other site 456481004080 lipoyl attachment site [posttranslational modification]; other site 456481004081 e3 binding domain; Region: E3_binding; pfam02817 456481004082 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 456481004083 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 456481004084 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 456481004085 alpha subunit interface [polypeptide binding]; other site 456481004086 TPP binding site [chemical binding]; other site 456481004087 heterodimer interface [polypeptide binding]; other site 456481004088 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 456481004089 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 456481004090 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 456481004091 tetramer interface [polypeptide binding]; other site 456481004092 TPP-binding site [chemical binding]; other site 456481004093 heterodimer interface [polypeptide binding]; other site 456481004094 phosphorylation loop region [posttranslational modification] 456481004095 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 456481004096 AMP binding site [chemical binding]; other site 456481004097 metal binding site [ion binding]; metal-binding site 456481004098 active site 456481004099 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 456481004100 Yqey-like protein; Region: YqeY; pfam09424 456481004101 CHC2 zinc finger; Region: zf-CHC2; cl17510 456481004102 DNA primase; Validated; Region: dnaG; PRK05667 456481004103 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 456481004104 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 456481004105 active site 456481004106 metal binding site [ion binding]; metal-binding site 456481004107 interdomain interaction site; other site 456481004108 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 456481004109 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 456481004110 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 456481004111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481004112 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 456481004113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481004114 DNA binding residues [nucleotide binding] 456481004115 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 456481004116 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 456481004117 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 456481004118 active site 456481004119 HIGH motif; other site 456481004120 dimer interface [polypeptide binding]; other site 456481004121 KMSKS motif; other site 456481004122 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 456481004123 RNA binding surface [nucleotide binding]; other site 456481004124 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 456481004125 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 456481004126 NodB motif; other site 456481004127 active site 456481004128 catalytic site [active] 456481004129 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 456481004130 Protein export membrane protein; Region: SecD_SecF; cl14618 456481004131 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 456481004132 active site 456481004133 catalytic residues [active] 456481004134 metal binding site [ion binding]; metal-binding site 456481004135 GAF domain; Region: GAF_3; pfam13492 456481004136 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481004137 GAF domain; Region: GAF; pfam01590 456481004138 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481004139 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004140 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481004141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 456481004142 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481004143 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481004144 anti sigma factor interaction site; other site 456481004145 regulatory phosphorylation site [posttranslational modification]; other site 456481004146 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 456481004147 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 456481004148 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 456481004149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 456481004150 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481004151 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 456481004152 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 456481004153 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 456481004154 carboxyltransferase (CT) interaction site; other site 456481004155 biotinylation site [posttranslational modification]; other site 456481004156 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 456481004157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004158 active site 456481004159 phosphorylation site [posttranslational modification] 456481004160 intermolecular recognition site; other site 456481004161 dimerization interface [polypeptide binding]; other site 456481004162 CheB methylesterase; Region: CheB_methylest; pfam01339 456481004163 CheD chemotactic sensory transduction; Region: CheD; cl00810 456481004164 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 456481004165 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481004166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481004167 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481004168 putative active site [active] 456481004169 heme pocket [chemical binding]; other site 456481004170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481004171 putative active site [active] 456481004172 heme pocket [chemical binding]; other site 456481004173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481004174 dimer interface [polypeptide binding]; other site 456481004175 putative CheW interface [polypeptide binding]; other site 456481004176 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 456481004177 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 456481004178 putative binding surface; other site 456481004179 active site 456481004180 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 456481004181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481004182 ATP binding site [chemical binding]; other site 456481004183 Mg2+ binding site [ion binding]; other site 456481004184 G-X-G motif; other site 456481004185 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 456481004186 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481004187 anti sigma factor interaction site; other site 456481004188 regulatory phosphorylation site [posttranslational modification]; other site 456481004189 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004191 active site 456481004192 phosphorylation site [posttranslational modification] 456481004193 intermolecular recognition site; other site 456481004194 dimerization interface [polypeptide binding]; other site 456481004195 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481004196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004197 active site 456481004198 phosphorylation site [posttranslational modification] 456481004199 intermolecular recognition site; other site 456481004200 dimerization interface [polypeptide binding]; other site 456481004201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481004202 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 456481004203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481004204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481004205 dimer interface [polypeptide binding]; other site 456481004206 phosphorylation site [posttranslational modification] 456481004207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481004208 ATP binding site [chemical binding]; other site 456481004209 Mg2+ binding site [ion binding]; other site 456481004210 G-X-G motif; other site 456481004211 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 456481004212 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 456481004213 flagellin; Provisional; Region: PRK12804 456481004214 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 456481004215 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 456481004216 threonine dehydratase; Validated; Region: PRK08639 456481004217 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 456481004218 tetramer interface [polypeptide binding]; other site 456481004219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481004220 catalytic residue [active] 456481004221 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 456481004222 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481004223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481004224 S-adenosylmethionine binding site [chemical binding]; other site 456481004225 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 456481004226 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 456481004227 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 456481004228 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 456481004229 homodimer interface [polypeptide binding]; other site 456481004230 substrate-cofactor binding pocket; other site 456481004231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481004232 catalytic residue [active] 456481004233 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 456481004234 RNA methyltransferase, RsmE family; Region: TIGR00046 456481004235 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 456481004236 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 456481004237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481004238 Walker A motif; other site 456481004239 ATP binding site [chemical binding]; other site 456481004240 Walker B motif; other site 456481004241 arginine finger; other site 456481004242 flagellar motor switch protein FliN; Region: fliN; TIGR02480 456481004243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481004244 Coenzyme A binding pocket [chemical binding]; other site 456481004245 RNHCP domain; Region: RNHCP; pfam12647 456481004246 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 456481004247 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 456481004248 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 456481004249 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 456481004250 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 456481004251 Haem-binding domain; Region: Haem_bd; pfam14376 456481004252 argininosuccinate lyase; Provisional; Region: PRK00855 456481004253 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 456481004254 active sites [active] 456481004255 tetramer interface [polypeptide binding]; other site 456481004256 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 456481004257 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 456481004258 active site 456481004259 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 456481004260 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 456481004261 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 456481004262 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 456481004263 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 456481004264 Uncharacterized conserved protein [Function unknown]; Region: COG4095 456481004265 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 456481004266 GMP synthase; Reviewed; Region: guaA; PRK00074 456481004267 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 456481004268 AMP/PPi binding site [chemical binding]; other site 456481004269 candidate oxyanion hole; other site 456481004270 catalytic triad [active] 456481004271 potential glutamine specificity residues [chemical binding]; other site 456481004272 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 456481004273 Ligand Binding Site [chemical binding]; other site 456481004274 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 456481004275 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 456481004276 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 456481004277 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 456481004278 putative metal binding site; other site 456481004279 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 456481004280 dimer interface [polypeptide binding]; other site 456481004281 active site 456481004282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481004283 Q-loop/lid; other site 456481004284 ABC transporter signature motif; other site 456481004285 Walker B; other site 456481004286 D-loop; other site 456481004287 H-loop/switch region; other site 456481004288 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 456481004289 phosphopeptide binding site; other site 456481004290 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 456481004291 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 456481004292 substrate binding site [chemical binding]; other site 456481004293 ligand binding site [chemical binding]; other site 456481004294 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 456481004295 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 456481004296 substrate binding site [chemical binding]; other site 456481004297 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 456481004298 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 456481004299 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 456481004300 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 456481004301 dimer interface [polypeptide binding]; other site 456481004302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481004303 catalytic residue [active] 456481004304 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481004305 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481004306 ligand binding site [chemical binding]; other site 456481004307 flexible hinge region; other site 456481004308 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 456481004309 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 456481004310 nucleophile elbow; other site 456481004311 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 456481004312 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 456481004313 Walker A/P-loop; other site 456481004314 ATP binding site [chemical binding]; other site 456481004315 Q-loop/lid; other site 456481004316 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 456481004317 Q-loop/lid; other site 456481004318 ABC transporter signature motif; other site 456481004319 Walker B; other site 456481004320 D-loop; other site 456481004321 H-loop/switch region; other site 456481004322 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 456481004323 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 456481004324 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 456481004325 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 456481004326 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 456481004327 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 456481004328 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 456481004329 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 456481004330 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 456481004331 Surface antigen; Region: Bac_surface_Ag; pfam01103 456481004332 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 456481004333 Part of AAA domain; Region: AAA_19; pfam13245 456481004334 Family description; Region: UvrD_C_2; pfam13538 456481004335 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 456481004336 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 456481004337 active site 456481004338 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 456481004339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481004340 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 456481004341 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 456481004342 catalytic residues [active] 456481004343 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 456481004344 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 456481004345 acyl-activating enzyme (AAE) consensus motif; other site 456481004346 putative AMP binding site [chemical binding]; other site 456481004347 putative active site [active] 456481004348 putative CoA binding site [chemical binding]; other site 456481004349 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 456481004350 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 456481004351 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 456481004352 putative ribose interaction site [chemical binding]; other site 456481004353 putative ADP binding site [chemical binding]; other site 456481004354 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 456481004355 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 456481004356 active site 456481004357 nucleotide binding site [chemical binding]; other site 456481004358 HIGH motif; other site 456481004359 KMSKS motif; other site 456481004360 CTP synthetase; Validated; Region: pyrG; PRK05380 456481004361 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 456481004362 Catalytic site [active] 456481004363 active site 456481004364 UTP binding site [chemical binding]; other site 456481004365 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 456481004366 active site 456481004367 putative oxyanion hole; other site 456481004368 catalytic triad [active] 456481004369 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 456481004370 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 456481004371 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 456481004372 OstA-like protein; Region: OstA; cl00844 456481004373 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 456481004374 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 456481004375 Walker A/P-loop; other site 456481004376 ATP binding site [chemical binding]; other site 456481004377 Q-loop/lid; other site 456481004378 ABC transporter signature motif; other site 456481004379 Walker B; other site 456481004380 D-loop; other site 456481004381 H-loop/switch region; other site 456481004382 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 456481004383 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 456481004384 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 456481004385 HPr kinase/phosphorylase; Provisional; Region: PRK05428 456481004386 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 456481004387 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 456481004388 Hpr binding site; other site 456481004389 active site 456481004390 homohexamer subunit interaction site [polypeptide binding]; other site 456481004391 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 456481004392 regulatory protein interface [polypeptide binding]; other site 456481004393 active site 456481004394 regulatory phosphorylation site [posttranslational modification]; other site 456481004395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481004396 dimerization interface [polypeptide binding]; other site 456481004397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481004398 dimer interface [polypeptide binding]; other site 456481004399 phosphorylation site [posttranslational modification] 456481004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481004401 ATP binding site [chemical binding]; other site 456481004402 Mg2+ binding site [ion binding]; other site 456481004403 G-X-G motif; other site 456481004404 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 456481004405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004406 active site 456481004407 phosphorylation site [posttranslational modification] 456481004408 intermolecular recognition site; other site 456481004409 dimerization interface [polypeptide binding]; other site 456481004410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481004411 Walker A motif; other site 456481004412 ATP binding site [chemical binding]; other site 456481004413 Walker B motif; other site 456481004414 arginine finger; other site 456481004415 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 456481004416 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 456481004417 primosome assembly protein PriA; Validated; Region: PRK05580 456481004418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481004419 ATP binding site [chemical binding]; other site 456481004420 putative Mg++ binding site [ion binding]; other site 456481004421 helicase superfamily c-terminal domain; Region: HELICc; smart00490 456481004422 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 456481004423 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 456481004424 putative active site [active] 456481004425 substrate binding site [chemical binding]; other site 456481004426 putative cosubstrate binding site; other site 456481004427 catalytic site [active] 456481004428 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 456481004429 substrate binding site [chemical binding]; other site 456481004430 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 456481004431 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 456481004432 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 456481004433 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 456481004434 substrate binding site [chemical binding]; other site 456481004435 hexamer interface [polypeptide binding]; other site 456481004436 metal binding site [ion binding]; metal-binding site 456481004437 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 456481004438 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 456481004439 hypothetical protein; Provisional; Region: PRK00468 456481004440 G-X-X-G motif; other site 456481004441 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590 456481004442 RimM N-terminal domain; Region: RimM; pfam01782 456481004443 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Provisional; Region: trmD; PRK14599 456481004444 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 456481004445 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 456481004446 RNA/DNA hybrid binding site [nucleotide binding]; other site 456481004447 active site 456481004448 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 456481004449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481004450 Zn2+ binding site [ion binding]; other site 456481004451 Mg2+ binding site [ion binding]; other site 456481004452 hypothetical protein; Reviewed; Region: PRK12497 456481004453 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 456481004454 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 456481004455 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 456481004456 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 456481004457 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 456481004458 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 456481004459 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481004460 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481004461 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481004462 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 456481004463 type II secretion system protein D; Region: type_II_gspD; TIGR02517 456481004464 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 456481004465 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 456481004466 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 456481004467 type II secretion system protein E; Region: type_II_gspE; TIGR02533 456481004468 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 456481004469 Walker A motif; other site 456481004470 ATP binding site [chemical binding]; other site 456481004471 Walker B motif; other site 456481004472 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 456481004473 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 456481004474 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 456481004475 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 456481004476 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 456481004477 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 456481004478 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 456481004479 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 456481004480 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 456481004481 Cell division protein FtsA; Region: FtsA; pfam14450 456481004482 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 456481004483 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 456481004484 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 456481004485 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 456481004486 Transcriptional regulator; Region: Transcrip_reg; cl00361 456481004487 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 456481004488 active site 456481004489 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 456481004490 TSCPD domain; Region: TSCPD; pfam12637 456481004491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 456481004492 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 456481004493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 456481004494 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481004495 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 456481004496 Sulfate transporter family; Region: Sulfate_transp; pfam00916 456481004497 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 456481004498 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 456481004499 active site clefts [active] 456481004500 zinc binding site [ion binding]; other site 456481004501 dimer interface [polypeptide binding]; other site 456481004502 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 456481004503 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 456481004504 putative Iron-sulfur protein interface [polypeptide binding]; other site 456481004505 proximal heme binding site [chemical binding]; other site 456481004506 distal heme binding site [chemical binding]; other site 456481004507 putative dimer interface [polypeptide binding]; other site 456481004508 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 456481004509 L-aspartate oxidase; Provisional; Region: PRK06175 456481004510 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 456481004511 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 456481004512 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 456481004513 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 456481004514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 456481004515 active site 456481004516 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 456481004517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481004518 GTP-binding protein LepA; Provisional; Region: PRK05433 456481004519 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 456481004520 G1 box; other site 456481004521 putative GEF interaction site [polypeptide binding]; other site 456481004522 GTP/Mg2+ binding site [chemical binding]; other site 456481004523 Switch I region; other site 456481004524 G2 box; other site 456481004525 G3 box; other site 456481004526 Switch II region; other site 456481004527 G4 box; other site 456481004528 G5 box; other site 456481004529 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 456481004530 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 456481004531 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 456481004532 enolase; Provisional; Region: eno; PRK00077 456481004533 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 456481004534 dimer interface [polypeptide binding]; other site 456481004535 metal binding site [ion binding]; metal-binding site 456481004536 substrate binding pocket [chemical binding]; other site 456481004537 Septum formation initiator; Region: DivIC; cl17659 456481004538 Clp protease; Region: CLP_protease; pfam00574 456481004539 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 456481004540 oligomer interface [polypeptide binding]; other site 456481004541 active site residues [active] 456481004542 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 456481004543 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 456481004544 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 456481004545 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 456481004546 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 456481004547 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481004548 anti sigma factor interaction site; other site 456481004549 regulatory phosphorylation site [posttranslational modification]; other site 456481004550 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 456481004551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481004552 non-specific DNA binding site [nucleotide binding]; other site 456481004553 salt bridge; other site 456481004554 sequence-specific DNA binding site [nucleotide binding]; other site 456481004555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481004556 non-specific DNA binding site [nucleotide binding]; other site 456481004557 salt bridge; other site 456481004558 sequence-specific DNA binding site [nucleotide binding]; other site 456481004559 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 456481004560 Na2 binding site [ion binding]; other site 456481004561 substrate binding site 1 [chemical binding]; other site 456481004562 Na binding site 1 [ion binding]; other site 456481004563 substrate binding site 2 [chemical binding]; other site 456481004564 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 456481004565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 456481004566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 456481004567 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 456481004568 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 456481004569 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 456481004570 Dimer interface [polypeptide binding]; other site 456481004571 anticodon binding site; other site 456481004572 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 456481004573 homodimer interface [polypeptide binding]; other site 456481004574 motif 1; other site 456481004575 motif 2; other site 456481004576 active site 456481004577 motif 3; other site 456481004578 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14177 456481004579 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 456481004580 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 456481004581 homodimer interface [polypeptide binding]; other site 456481004582 NADP binding site [chemical binding]; other site 456481004583 substrate binding site [chemical binding]; other site 456481004584 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 456481004585 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481004586 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 456481004587 active site 456481004588 HIGH motif; other site 456481004589 nucleotide binding site [chemical binding]; other site 456481004590 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481004591 active site 456481004592 KMSKS motif; other site 456481004593 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 456481004594 tRNA binding surface [nucleotide binding]; other site 456481004595 anticodon binding site; other site 456481004596 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 456481004597 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 456481004598 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 456481004599 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 456481004600 PGAP1-like protein; Region: PGAP1; pfam07819 456481004601 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 456481004602 Na binding site [ion binding]; other site 456481004603 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 456481004604 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 456481004605 substrate binding site [chemical binding]; other site 456481004606 glutamase interaction surface [polypeptide binding]; other site 456481004607 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 456481004608 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 456481004609 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 456481004610 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 456481004611 Bacterial sugar transferase; Region: Bac_transf; pfam02397 456481004612 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 456481004613 Response regulator receiver domain; Region: Response_reg; pfam00072 456481004614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481004615 active site 456481004616 phosphorylation site [posttranslational modification] 456481004617 intermolecular recognition site; other site 456481004618 dimerization interface [polypeptide binding]; other site 456481004619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481004620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481004621 dimer interface [polypeptide binding]; other site 456481004622 phosphorylation site [posttranslational modification] 456481004623 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 456481004624 Part of AAA domain; Region: AAA_19; pfam13245 456481004625 Family description; Region: UvrD_C_2; pfam13538 456481004626 MORN repeat; Region: MORN; cl14787 456481004627 Peptidase family M48; Region: Peptidase_M48; pfam01435 456481004628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481004629 PAS domain; Region: PAS_9; pfam13426 456481004630 putative active site [active] 456481004631 heme pocket [chemical binding]; other site 456481004632 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481004633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481004634 metal binding site [ion binding]; metal-binding site 456481004635 active site 456481004636 I-site; other site 456481004637 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481004638 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481004639 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481004640 anti sigma factor interaction site; other site 456481004641 regulatory phosphorylation site [posttranslational modification]; other site 456481004642 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 456481004643 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481004644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481004645 dimerization interface [polypeptide binding]; other site 456481004646 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004647 Protease prsW family; Region: PrsW-protease; pfam13367 456481004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 456481004649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481004650 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 456481004651 Walker A motif; other site 456481004652 ATP binding site [chemical binding]; other site 456481004653 Walker B motif; other site 456481004654 arginine finger; other site 456481004655 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 456481004656 active site 456481004657 catalytic triad [active] 456481004658 dimer interface [polypeptide binding]; other site 456481004659 lipoprotein signal peptidase; Provisional; Region: PRK14783 456481004660 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 456481004661 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 456481004662 active site 456481004663 ATP binding site [chemical binding]; other site 456481004664 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 456481004665 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 456481004666 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 456481004667 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 456481004668 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 456481004669 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 456481004670 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 456481004671 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 456481004672 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 456481004673 ATP-grasp domain; Region: ATP-grasp; pfam02222 456481004674 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 456481004675 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 456481004676 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 456481004677 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 456481004678 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 456481004679 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 456481004680 homodimer interface [polypeptide binding]; other site 456481004681 active site 456481004682 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 456481004683 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 456481004684 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 456481004685 Mg++ binding site [ion binding]; other site 456481004686 putative catalytic motif [active] 456481004687 putative substrate binding site [chemical binding]; other site 456481004688 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 456481004689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 456481004690 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 456481004691 MraW methylase family; Region: Methyltransf_5; cl17771 456481004692 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 456481004693 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 456481004694 nucleotide binding site/active site [active] 456481004695 HIT family signature motif; other site 456481004696 catalytic residue [active] 456481004697 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 456481004698 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 456481004699 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 456481004700 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 456481004701 ammonium transporter; Region: amt; TIGR00836 456481004702 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481004703 GAF domain; Region: GAF; pfam01590 456481004704 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481004706 binding surface 456481004707 TPR motif; other site 456481004708 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481004709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481004710 binding surface 456481004711 TPR motif; other site 456481004712 TPR repeat; Region: TPR_11; pfam13414 456481004713 Putative Fe-S cluster; Region: FeS; cl17515 456481004714 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 456481004715 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 456481004716 G1 box; other site 456481004717 putative GEF interaction site [polypeptide binding]; other site 456481004718 GTP/Mg2+ binding site [chemical binding]; other site 456481004719 Switch I region; other site 456481004720 G2 box; other site 456481004721 G3 box; other site 456481004722 Switch II region; other site 456481004723 G4 box; other site 456481004724 G5 box; other site 456481004725 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 456481004726 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 456481004727 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 456481004728 Protein of unknown function (DUF464); Region: DUF464; pfam04327 456481004729 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 456481004730 GTPase CgtA; Reviewed; Region: obgE; PRK12299 456481004731 GTP1/OBG; Region: GTP1_OBG; pfam01018 456481004732 Obg GTPase; Region: Obg; cd01898 456481004733 G1 box; other site 456481004734 GTP/Mg2+ binding site [chemical binding]; other site 456481004735 Switch I region; other site 456481004736 G2 box; other site 456481004737 G3 box; other site 456481004738 Switch II region; other site 456481004739 G4 box; other site 456481004740 G5 box; other site 456481004741 gamma-glutamyl kinase; Provisional; Region: PRK05429 456481004742 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 456481004743 nucleotide binding site [chemical binding]; other site 456481004744 homotetrameric interface [polypeptide binding]; other site 456481004745 putative phosphate binding site [ion binding]; other site 456481004746 putative allosteric binding site; other site 456481004747 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 456481004748 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 456481004749 putative catalytic cysteine [active] 456481004750 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 456481004751 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 456481004752 active site 456481004753 (T/H)XGH motif; other site 456481004754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481004755 Zn2+ binding site [ion binding]; other site 456481004756 Mg2+ binding site [ion binding]; other site 456481004757 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 456481004758 Oligomerisation domain; Region: Oligomerisation; pfam02410 456481004759 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 456481004760 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 456481004761 catalytic residues [active] 456481004762 Outer membrane efflux protein; Region: OEP; pfam02321 456481004763 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 456481004764 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 456481004765 metal binding site [ion binding]; metal-binding site 456481004766 dimer interface [polypeptide binding]; other site 456481004767 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 456481004768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481004769 substrate binding site [chemical binding]; other site 456481004770 oxyanion hole (OAH) forming residues; other site 456481004771 trimer interface [polypeptide binding]; other site 456481004772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 456481004773 MarR family; Region: MarR_2; pfam12802 456481004774 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 456481004775 proline aminopeptidase P II; Provisional; Region: PRK10879 456481004776 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 456481004777 active site 456481004778 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 456481004779 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 456481004780 putative active site [active] 456481004781 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 456481004782 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 456481004783 active site 456481004784 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 456481004785 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 456481004786 heme binding site [chemical binding]; other site 456481004787 ferroxidase pore; other site 456481004788 ferroxidase diiron center [ion binding]; other site 456481004789 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 456481004790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 456481004791 acetylglutamate kinase; Provisional; Region: PRK04531 456481004792 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 456481004793 nucleotide binding site [chemical binding]; other site 456481004794 substrate binding site [chemical binding]; other site 456481004795 DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases; Region: DUF619-like; cl14605 456481004796 Protein of unknown function, DUF393; Region: DUF393; cl01136 456481004797 Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981 456481004798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481004799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481004800 Radical SAM superfamily; Region: Radical_SAM; pfam04055 456481004801 FeS/SAM binding site; other site 456481004802 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 456481004803 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 456481004804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481004805 motif II; other site 456481004806 Sporulation and spore germination; Region: Germane; pfam10646 456481004807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481004808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481004809 metal binding site [ion binding]; metal-binding site 456481004810 active site 456481004811 I-site; other site 456481004812 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 456481004813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481004814 FeS/SAM binding site; other site 456481004815 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 456481004816 Cysteine-rich domain; Region: CCG; pfam02754 456481004817 Cysteine-rich domain; Region: CCG; pfam02754 456481004818 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481004819 FecR protein; Region: FecR; pfam04773 456481004820 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481004821 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004822 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 456481004823 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 456481004824 G1 box; other site 456481004825 putative GEF interaction site [polypeptide binding]; other site 456481004826 GTP/Mg2+ binding site [chemical binding]; other site 456481004827 Switch I region; other site 456481004828 G2 box; other site 456481004829 G3 box; other site 456481004830 Switch II region; other site 456481004831 G4 box; other site 456481004832 G5 box; other site 456481004833 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 456481004834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481004835 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481004836 binding surface 456481004837 TPR motif; other site 456481004838 NHL repeat; Region: NHL; pfam01436 456481004839 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 456481004840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481004841 binding surface 456481004842 TPR motif; other site 456481004843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481004844 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481004845 TPR motif; other site 456481004846 binding surface 456481004847 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 456481004848 hydrophobic ligand binding site; other site 456481004849 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 456481004850 active site 456481004851 dimer interfaces [polypeptide binding]; other site 456481004852 catalytic residues [active] 456481004853 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 456481004854 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 456481004855 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 456481004856 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 456481004857 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14332 456481004858 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 456481004859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481004860 FeS/SAM binding site; other site 456481004861 TRAM domain; Region: TRAM; cl01282 456481004862 DnaJ domain; Region: DnaJ; pfam00226 456481004863 HSP70 interaction site [polypeptide binding]; other site 456481004864 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481004865 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481004866 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 456481004867 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 456481004868 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 456481004869 putative RNA binding site [nucleotide binding]; other site 456481004870 Methyltransferase domain; Region: Methyltransf_26; pfam13659 456481004871 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481004872 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481004874 TPR motif; other site 456481004875 binding surface 456481004876 Bacitracin resistance protein BacA; Region: BacA; pfam02673 456481004877 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 456481004878 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 456481004879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481004880 ATP binding site [chemical binding]; other site 456481004881 putative Mg++ binding site [ion binding]; other site 456481004882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481004883 nucleotide binding region [chemical binding]; other site 456481004884 ATP-binding site [chemical binding]; other site 456481004885 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 456481004886 pantoate--beta-alanine ligase; Region: panC; TIGR00018 456481004887 Pantoate-beta-alanine ligase; Region: PanC; cd00560 456481004888 active site 456481004889 ATP-binding site [chemical binding]; other site 456481004890 pantoate-binding site; other site 456481004891 HXXH motif; other site 456481004892 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 456481004893 histidinol dehydrogenase; Region: hisD; TIGR00069 456481004894 NAD binding site [chemical binding]; other site 456481004895 dimerization interface [polypeptide binding]; other site 456481004896 product binding site; other site 456481004897 substrate binding site [chemical binding]; other site 456481004898 zinc binding site [ion binding]; other site 456481004899 catalytic residues [active] 456481004900 FecR protein; Region: FecR; pfam04773 456481004901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481004902 dimerization interface [polypeptide binding]; other site 456481004903 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481004904 cyclase homology domain; Region: CHD; cd07302 456481004905 nucleotidyl binding site; other site 456481004906 metal binding site [ion binding]; metal-binding site 456481004907 dimer interface [polypeptide binding]; other site 456481004908 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 456481004909 putative catalytic site [active] 456481004910 putative metal binding site [ion binding]; other site 456481004911 putative phosphate binding site [ion binding]; other site 456481004912 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 456481004913 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 456481004914 MgtE intracellular N domain; Region: MgtE_N; pfam03448 456481004915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 456481004916 Divalent cation transporter; Region: MgtE; pfam01769 456481004917 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481004918 ligand binding site [chemical binding]; other site 456481004919 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 456481004920 Acyl-CoA dehydrogenase, middle domain; Region: Acyl-CoA_dh_M; pfam02770 456481004921 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 456481004922 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 456481004923 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 456481004924 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 456481004925 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 456481004926 active site 456481004927 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 456481004928 tandem repeat interface [polypeptide binding]; other site 456481004929 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 456481004930 oligomer interface [polypeptide binding]; other site 456481004931 active site residues [active] 456481004932 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 456481004933 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 456481004934 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 456481004935 active site 456481004936 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 456481004937 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 456481004938 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 456481004939 active site 456481004940 catalytic site [active] 456481004941 2-isopropylmalate synthase; Validated; Region: PRK00915 456481004942 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 456481004943 active site 456481004944 catalytic residues [active] 456481004945 metal binding site [ion binding]; metal-binding site 456481004946 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 456481004947 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 456481004948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481004949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481004950 homodimer interface [polypeptide binding]; other site 456481004951 catalytic residue [active] 456481004952 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 456481004953 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 456481004954 putative dimer interface [polypeptide binding]; other site 456481004955 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 456481004956 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 456481004957 putative dimer interface [polypeptide binding]; other site 456481004958 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 456481004959 homotrimer interaction site [polypeptide binding]; other site 456481004960 putative active site [active] 456481004961 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 456481004962 Clp amino terminal domain; Region: Clp_N; pfam02861 456481004963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481004964 Walker A motif; other site 456481004965 ATP binding site [chemical binding]; other site 456481004966 Walker B motif; other site 456481004967 arginine finger; other site 456481004968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481004969 Walker A motif; other site 456481004970 ATP binding site [chemical binding]; other site 456481004971 Walker B motif; other site 456481004972 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 456481004973 Uncharacterized conserved protein [Function unknown]; Region: COG2127 456481004974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 456481004975 Protein of unknown function, DUF482; Region: DUF482; pfam04339 456481004976 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 456481004977 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 456481004978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481004979 dimerization interface [polypeptide binding]; other site 456481004980 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481004981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481004982 binding surface 456481004983 TPR motif; other site 456481004984 TPR repeat; Region: TPR_11; pfam13414 456481004985 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 456481004986 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 456481004987 Domain of unknown function DUF20; Region: UPF0118; pfam01594 456481004988 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 456481004989 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 456481004990 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 456481004991 generic binding surface II; other site 456481004992 generic binding surface I; other site 456481004993 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14069 456481004994 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 456481004995 Na binding site [ion binding]; other site 456481004996 putative glycosylation site [posttranslational modification]; other site 456481004997 putative glycosylation site [posttranslational modification]; other site 456481004998 D-alanyl-alanine synthetase A; Provisional; Region: PRK14572 456481004999 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 456481005000 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481005001 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 456481005002 Permease; Region: Permease; pfam02405 456481005003 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 456481005004 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 456481005005 Walker A/P-loop; other site 456481005006 ATP binding site [chemical binding]; other site 456481005007 Q-loop/lid; other site 456481005008 ABC transporter signature motif; other site 456481005009 Walker B; other site 456481005010 D-loop; other site 456481005011 H-loop/switch region; other site 456481005012 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 456481005013 mce related protein; Region: MCE; pfam02470 456481005014 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 456481005015 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 456481005016 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 456481005017 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 456481005018 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 456481005019 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 456481005020 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 456481005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481005022 POT family; Region: PTR2; cl17359 456481005023 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 456481005024 flagellin; Provisional; Region: PRK12804 456481005025 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 456481005026 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 456481005027 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481005028 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481005029 ligand binding site [chemical binding]; other site 456481005030 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 456481005031 Voltage-dependent potassium channel; Provisional; Region: PLN03192 456481005032 Ion channel; Region: Ion_trans_2; pfam07885 456481005033 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481005034 ligand binding site [chemical binding]; other site 456481005035 flexible hinge region; other site 456481005036 AAA domain; Region: AAA_31; pfam13614 456481005037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481005038 P-loop; other site 456481005039 Magnesium ion binding site [ion binding]; other site 456481005040 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481005041 Magnesium ion binding site [ion binding]; other site 456481005042 YopX protein; Region: YopX; cl09859 456481005043 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481005044 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 456481005045 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 456481005046 acyl-activating enzyme (AAE) consensus motif; other site 456481005047 acyl-activating enzyme (AAE) consensus motif; other site 456481005048 putative AMP binding site [chemical binding]; other site 456481005049 putative active site [active] 456481005050 putative CoA binding site [chemical binding]; other site 456481005051 aminopeptidase N; Provisional; Region: pepN; PRK14015 456481005052 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 456481005053 active site 456481005054 Zn binding site [ion binding]; other site 456481005055 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 456481005056 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481005057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481005058 active site 456481005059 phosphorylation site [posttranslational modification] 456481005060 intermolecular recognition site; other site 456481005061 dimerization interface [polypeptide binding]; other site 456481005062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481005063 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481005064 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 456481005065 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 456481005066 N-terminal plug; other site 456481005067 ligand-binding site [chemical binding]; other site 456481005068 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 456481005069 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 456481005070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481005071 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 456481005072 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 456481005073 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 456481005074 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 456481005075 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 456481005076 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 456481005077 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 456481005078 dimer interface [polypeptide binding]; other site 456481005079 putative anticodon binding site; other site 456481005080 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 456481005081 motif 1; other site 456481005082 active site 456481005083 motif 2; other site 456481005084 motif 3; other site 456481005085 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 456481005086 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 456481005087 ligand binding site [chemical binding]; other site 456481005088 NAD binding site [chemical binding]; other site 456481005089 tetramer interface [polypeptide binding]; other site 456481005090 catalytic site [active] 456481005091 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 456481005092 L-serine binding site [chemical binding]; other site 456481005093 ACT domain interface; other site 456481005094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 456481005095 MAPEG family; Region: MAPEG; cl09190 456481005096 Endonuclease I; Region: Endonuclease_1; pfam04231 456481005097 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 456481005098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481005099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 456481005100 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 456481005101 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 456481005102 active site residue [active] 456481005103 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 456481005104 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 456481005105 Walker A/P-loop; other site 456481005106 ATP binding site [chemical binding]; other site 456481005107 Q-loop/lid; other site 456481005108 ABC transporter signature motif; other site 456481005109 Walker B; other site 456481005110 D-loop; other site 456481005111 H-loop/switch region; other site 456481005112 inner membrane transport permease; Provisional; Region: PRK15066 456481005113 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 456481005114 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 456481005115 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 456481005116 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481005117 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 456481005118 N-terminal domain interface [polypeptide binding]; other site 456481005119 dimer interface [polypeptide binding]; other site 456481005120 substrate binding pocket (H-site) [chemical binding]; other site 456481005121 BolA-like protein; Region: BolA; pfam01722 456481005122 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 456481005123 putative GSH binding site [chemical binding]; other site 456481005124 catalytic residues [active] 456481005125 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481005126 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 456481005127 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481005128 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 456481005129 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 456481005130 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 456481005131 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 456481005132 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 456481005133 active site 456481005134 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 456481005135 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 456481005136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481005137 catalytic residue [active] 456481005138 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 456481005139 [2Fe-2S] cluster binding site [ion binding]; other site 456481005140 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 456481005141 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 456481005142 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 456481005143 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 456481005144 Walker A/P-loop; other site 456481005145 ATP binding site [chemical binding]; other site 456481005146 Q-loop/lid; other site 456481005147 ABC transporter signature motif; other site 456481005148 Walker B; other site 456481005149 D-loop; other site 456481005150 H-loop/switch region; other site 456481005151 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481005152 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 456481005153 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 456481005154 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 456481005155 ligand binding site; other site 456481005156 oligomer interface; other site 456481005157 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 456481005158 dimer interface [polypeptide binding]; other site 456481005159 N-terminal domain interface [polypeptide binding]; other site 456481005160 sulfate 1 binding site; other site 456481005161 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 456481005162 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 456481005163 putative active site [active] 456481005164 catalytic triad [active] 456481005165 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 456481005166 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 456481005167 ATP binding site [chemical binding]; other site 456481005168 active site 456481005169 substrate binding site [chemical binding]; other site 456481005170 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481005171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481005172 active site 456481005173 phosphorylation site [posttranslational modification] 456481005174 intermolecular recognition site; other site 456481005175 dimerization interface [polypeptide binding]; other site 456481005176 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481005177 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 456481005178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481005179 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 456481005180 Walker A/P-loop; other site 456481005181 ATP binding site [chemical binding]; other site 456481005182 Q-loop/lid; other site 456481005183 ABC transporter signature motif; other site 456481005184 Walker B; other site 456481005185 D-loop; other site 456481005186 H-loop/switch region; other site 456481005187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005188 binding surface 456481005189 TPR motif; other site 456481005190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005191 binding surface 456481005192 TPR motif; other site 456481005193 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 456481005194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 456481005195 Walker A/P-loop; other site 456481005196 ATP binding site [chemical binding]; other site 456481005197 Q-loop/lid; other site 456481005198 ABC transporter signature motif; other site 456481005199 Walker B; other site 456481005200 D-loop; other site 456481005201 H-loop/switch region; other site 456481005202 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 456481005203 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 456481005204 active site 456481005205 catalytic residues [active] 456481005206 metal binding site [ion binding]; metal-binding site 456481005207 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 456481005208 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 456481005209 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 456481005210 GDP-binding site [chemical binding]; other site 456481005211 ACT binding site; other site 456481005212 IMP binding site; other site 456481005213 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 456481005214 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 456481005215 motif 1; other site 456481005216 dimer interface [polypeptide binding]; other site 456481005217 active site 456481005218 motif 2; other site 456481005219 motif 3; other site 456481005220 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 456481005221 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481005222 putative acyl-acceptor binding pocket; other site 456481005223 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 456481005224 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 456481005225 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 456481005226 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481005227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 456481005228 putative active site [active] 456481005229 heme pocket [chemical binding]; other site 456481005230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481005231 putative active site [active] 456481005232 heme pocket [chemical binding]; other site 456481005233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481005234 dimer interface [polypeptide binding]; other site 456481005235 phosphorylation site [posttranslational modification] 456481005236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481005237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005238 ATP binding site [chemical binding]; other site 456481005239 Mg2+ binding site [ion binding]; other site 456481005240 G-X-G motif; other site 456481005241 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 456481005242 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 456481005243 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 456481005244 alphaNTD - beta interaction site [polypeptide binding]; other site 456481005245 alphaNTD homodimer interface [polypeptide binding]; other site 456481005246 alphaNTD - beta' interaction site [polypeptide binding]; other site 456481005247 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 456481005248 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 456481005249 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 456481005250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 456481005251 RNA binding surface [nucleotide binding]; other site 456481005252 30S ribosomal protein S11; Validated; Region: PRK05309 456481005253 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 456481005254 30S ribosomal protein S13; Region: bact_S13; TIGR03631 456481005255 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 456481005256 rRNA binding site [nucleotide binding]; other site 456481005257 predicted 30S ribosome binding site; other site 456481005258 adenylate kinase; Provisional; Region: PRK14528 456481005259 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 456481005260 AMP-binding site [chemical binding]; other site 456481005261 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 456481005262 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 456481005263 SecY translocase; Region: SecY; pfam00344 456481005264 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 456481005265 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 456481005266 23S rRNA binding site [nucleotide binding]; other site 456481005267 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 456481005268 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 456481005269 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 456481005270 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 456481005271 23S rRNA interface [nucleotide binding]; other site 456481005272 5S rRNA interface [nucleotide binding]; other site 456481005273 L27 interface [polypeptide binding]; other site 456481005274 L5 interface [polypeptide binding]; other site 456481005275 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 456481005276 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 456481005277 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 456481005278 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 456481005279 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 456481005280 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 456481005281 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 456481005282 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 456481005283 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 456481005284 RNA binding site [nucleotide binding]; other site 456481005285 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 456481005286 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 456481005287 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 456481005288 putative translocon interaction site; other site 456481005289 23S rRNA interface [nucleotide binding]; other site 456481005290 signal recognition particle (SRP54) interaction site; other site 456481005291 L23 interface [polypeptide binding]; other site 456481005292 trigger factor interaction site; other site 456481005293 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 456481005294 23S rRNA interface [nucleotide binding]; other site 456481005295 5S rRNA interface [nucleotide binding]; other site 456481005296 putative antibiotic binding site [chemical binding]; other site 456481005297 L25 interface [polypeptide binding]; other site 456481005298 L27 interface [polypeptide binding]; other site 456481005299 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 456481005300 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 456481005301 G-X-X-G motif; other site 456481005302 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 456481005303 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 456481005304 putative translocon binding site; other site 456481005305 protein-rRNA interface [nucleotide binding]; other site 456481005306 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 456481005307 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 456481005308 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 456481005309 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 456481005310 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 456481005311 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 456481005312 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 456481005313 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 456481005314 elongation factor Tu; Reviewed; Region: PRK00049 456481005315 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 456481005316 G1 box; other site 456481005317 GEF interaction site [polypeptide binding]; other site 456481005318 GTP/Mg2+ binding site [chemical binding]; other site 456481005319 Switch I region; other site 456481005320 G2 box; other site 456481005321 G3 box; other site 456481005322 Switch II region; other site 456481005323 G4 box; other site 456481005324 G5 box; other site 456481005325 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 456481005326 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 456481005327 Antibiotic Binding Site [chemical binding]; other site 456481005328 elongation factor G; Reviewed; Region: PRK13351 456481005329 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 456481005330 G1 box; other site 456481005331 GTP/Mg2+ binding site [chemical binding]; other site 456481005332 G2 box; other site 456481005333 Switch I region; other site 456481005334 G3 box; other site 456481005335 Switch II region; other site 456481005336 G4 box; other site 456481005337 G5 box; other site 456481005338 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514 456481005339 30S ribosomal protein S7; Validated; Region: PRK05302 456481005340 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 456481005341 S17 interaction site [polypeptide binding]; other site 456481005342 S8 interaction site; other site 456481005343 16S rRNA interaction site [nucleotide binding]; other site 456481005344 streptomycin interaction site [chemical binding]; other site 456481005345 23S rRNA interaction site [nucleotide binding]; other site 456481005346 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 456481005347 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 456481005348 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 456481005349 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 456481005350 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 456481005351 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 456481005352 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 456481005353 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 456481005354 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 456481005355 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 456481005356 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 456481005357 DNA binding site [nucleotide binding] 456481005358 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 456481005359 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 456481005360 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 456481005361 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 456481005362 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 456481005363 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 456481005364 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 456481005365 RPB10 interaction site [polypeptide binding]; other site 456481005366 RPB1 interaction site [polypeptide binding]; other site 456481005367 RPB11 interaction site [polypeptide binding]; other site 456481005368 RPB3 interaction site [polypeptide binding]; other site 456481005369 RPB12 interaction site [polypeptide binding]; other site 456481005370 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 456481005371 core dimer interface [polypeptide binding]; other site 456481005372 peripheral dimer interface [polypeptide binding]; other site 456481005373 L10 interface [polypeptide binding]; other site 456481005374 L11 interface [polypeptide binding]; other site 456481005375 putative EF-Tu interaction site [polypeptide binding]; other site 456481005376 putative EF-G interaction site [polypeptide binding]; other site 456481005377 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 456481005378 23S rRNA interface [nucleotide binding]; other site 456481005379 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 456481005380 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 456481005381 mRNA/rRNA interface [nucleotide binding]; other site 456481005382 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 456481005383 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 456481005384 23S rRNA interface [nucleotide binding]; other site 456481005385 L7/L12 interface [polypeptide binding]; other site 456481005386 putative thiostrepton binding site; other site 456481005387 L25 interface [polypeptide binding]; other site 456481005388 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 456481005389 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 456481005390 putative homodimer interface [polypeptide binding]; other site 456481005391 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 456481005392 heterodimer interface [polypeptide binding]; other site 456481005393 homodimer interface [polypeptide binding]; other site 456481005394 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 456481005395 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 456481005396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481005397 NAD(P) binding site [chemical binding]; other site 456481005398 active site 456481005399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481005400 dimerization interface [polypeptide binding]; other site 456481005401 putative DNA binding site [nucleotide binding]; other site 456481005402 putative Zn2+ binding site [ion binding]; other site 456481005403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481005404 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 456481005405 NAD(P) binding site [chemical binding]; other site 456481005406 active site 456481005407 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 456481005408 Uncharacterized conserved protein [Function unknown]; Region: COG4850 456481005409 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 456481005410 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 456481005411 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 456481005412 Ligand binding site; other site 456481005413 Putative Catalytic site; other site 456481005414 DXD motif; other site 456481005415 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 456481005416 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 456481005417 Ligand binding site; other site 456481005418 Putative Catalytic site; other site 456481005419 DXD motif; other site 456481005420 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 456481005421 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 456481005422 Putative Catalytic site; other site 456481005423 DXD motif; other site 456481005424 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 456481005425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 456481005426 active site 456481005427 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 456481005428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481005429 UDP-galactopyranose mutase; Region: GLF; pfam03275 456481005430 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 456481005431 metal-binding site 456481005432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481005433 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 456481005434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481005435 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 456481005436 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 456481005437 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 456481005438 metal-binding site 456481005439 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 456481005440 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 456481005441 putative ligand binding site [chemical binding]; other site 456481005442 putative NAD binding site [chemical binding]; other site 456481005443 catalytic site [active] 456481005444 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 456481005445 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481005446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481005447 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 456481005448 active site 456481005449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481005450 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 456481005451 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 456481005452 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 456481005453 inhibitor-cofactor binding pocket; inhibition site 456481005454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481005455 catalytic residue [active] 456481005456 WxcM-like, C-terminal; Region: FdtA; pfam05523 456481005457 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481005458 Methyltransferase domain; Region: Methyltransf_11; pfam08241 456481005459 S-adenosylmethionine binding site [chemical binding]; other site 456481005460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481005461 active site 456481005462 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 456481005463 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 456481005464 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 456481005465 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 456481005466 Walker A/P-loop; other site 456481005467 ATP binding site [chemical binding]; other site 456481005468 Q-loop/lid; other site 456481005469 ABC transporter signature motif; other site 456481005470 Walker B; other site 456481005471 D-loop; other site 456481005472 H-loop/switch region; other site 456481005473 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 456481005474 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 456481005475 trimer interface [polypeptide binding]; other site 456481005476 active site 456481005477 substrate binding site [chemical binding]; other site 456481005478 CoA binding site [chemical binding]; other site 456481005479 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 456481005480 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 456481005481 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 456481005482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 456481005483 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 456481005484 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 456481005485 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 456481005486 inhibitor-cofactor binding pocket; inhibition site 456481005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481005488 catalytic residue [active] 456481005489 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 456481005490 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 456481005491 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 456481005492 ligand binding site; other site 456481005493 pseudaminic acid synthase; Region: PseI; TIGR03586 456481005494 NeuB family; Region: NeuB; pfam03102 456481005495 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 456481005496 NeuB binding interface [polypeptide binding]; other site 456481005497 putative substrate binding site [chemical binding]; other site 456481005498 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_1; cd08821 456481005499 putative active site [active] 456481005500 putative substrate binding site [chemical binding]; other site 456481005501 putative cosubstrate binding site; other site 456481005502 catalytic site [active] 456481005503 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 456481005504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 456481005505 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 456481005506 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 456481005507 Coenzyme A binding pocket [chemical binding]; other site 456481005508 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 456481005509 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 456481005510 ligand binding site; other site 456481005511 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 456481005512 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481005513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481005514 catalytic residue [active] 456481005515 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 456481005516 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 456481005517 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 456481005518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 456481005519 active site 456481005520 catalytic tetrad [active] 456481005521 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 456481005522 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 456481005523 inhibitor-cofactor binding pocket; inhibition site 456481005524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481005525 catalytic residue [active] 456481005526 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 456481005527 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 456481005528 NAD(P) binding site [chemical binding]; other site 456481005529 homodimer interface [polypeptide binding]; other site 456481005530 substrate binding site [chemical binding]; other site 456481005531 active site 456481005532 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 456481005533 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 456481005534 NADP binding site [chemical binding]; other site 456481005535 active site 456481005536 putative substrate binding site [chemical binding]; other site 456481005537 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 456481005538 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 456481005539 NAD binding site [chemical binding]; other site 456481005540 substrate binding site [chemical binding]; other site 456481005541 homodimer interface [polypeptide binding]; other site 456481005542 active site 456481005543 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 456481005544 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 456481005545 substrate binding site; other site 456481005546 tetramer interface; other site 456481005547 Transcriptional regulators [Transcription]; Region: MarR; COG1846 456481005548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 456481005549 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 456481005550 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 456481005551 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481005552 putative acyl-acceptor binding pocket; other site 456481005553 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 456481005554 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 456481005555 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 456481005556 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 456481005557 active site 456481005558 FMN binding site [chemical binding]; other site 456481005559 2,4-decadienoyl-CoA binding site; other site 456481005560 catalytic residue [active] 456481005561 4Fe-4S cluster binding site [ion binding]; other site 456481005562 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 456481005563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481005564 Response regulator receiver domain; Region: Response_reg; pfam00072 456481005565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481005566 active site 456481005567 phosphorylation site [posttranslational modification] 456481005568 intermolecular recognition site; other site 456481005569 dimerization interface [polypeptide binding]; other site 456481005570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481005571 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481005572 putative active site [active] 456481005573 heme pocket [chemical binding]; other site 456481005574 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481005575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481005576 putative active site [active] 456481005577 heme pocket [chemical binding]; other site 456481005578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481005579 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481005580 putative active site [active] 456481005581 heme pocket [chemical binding]; other site 456481005582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 456481005583 putative active site [active] 456481005584 heme pocket [chemical binding]; other site 456481005585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481005586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005587 ATP binding site [chemical binding]; other site 456481005588 Mg2+ binding site [ion binding]; other site 456481005589 G-X-G motif; other site 456481005590 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 456481005591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481005592 NAD(P) binding site [chemical binding]; other site 456481005593 active site 456481005594 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481005595 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481005596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005597 binding surface 456481005598 TPR motif; other site 456481005599 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 456481005600 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 456481005601 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 456481005602 Interdomain contacts; other site 456481005603 Cytokine receptor motif; other site 456481005604 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 456481005605 Interdomain contacts; other site 456481005606 Cytokine receptor motif; other site 456481005607 Thrombospondin type 1 repeats; Region: TSP1; smart00209 456481005608 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 456481005609 active site 456481005610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 456481005611 PAS domain; Region: PAS_9; pfam13426 456481005612 putative active site [active] 456481005613 heme pocket [chemical binding]; other site 456481005614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481005615 PAS domain; Region: PAS_9; pfam13426 456481005616 putative active site [active] 456481005617 heme pocket [chemical binding]; other site 456481005618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481005619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005620 ATP binding site [chemical binding]; other site 456481005621 Mg2+ binding site [ion binding]; other site 456481005622 G-X-G motif; other site 456481005623 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 456481005624 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 456481005625 CoA-ligase; Region: Ligase_CoA; pfam00549 456481005626 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 456481005627 CoA binding domain; Region: CoA_binding; smart00881 456481005628 CoA-ligase; Region: Ligase_CoA; pfam00549 456481005629 Outer membrane efflux protein; Region: OEP; pfam02321 456481005630 Outer membrane efflux protein; Region: OEP; pfam02321 456481005631 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 456481005632 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 456481005633 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 456481005634 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 456481005635 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 456481005636 Part of AAA domain; Region: AAA_19; pfam13245 456481005637 Family description; Region: UvrD_C_2; pfam13538 456481005638 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 456481005639 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 456481005640 C-terminal domain interface [polypeptide binding]; other site 456481005641 GSH binding site (G-site) [chemical binding]; other site 456481005642 dimer interface [polypeptide binding]; other site 456481005643 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 456481005644 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 456481005645 dimer interface [polypeptide binding]; other site 456481005646 ADP-ribose binding site [chemical binding]; other site 456481005647 active site 456481005648 nudix motif; other site 456481005649 metal binding site [ion binding]; metal-binding site 456481005650 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481005651 FecR protein; Region: FecR; pfam04773 456481005652 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 456481005653 enterobactin exporter EntS; Provisional; Region: PRK10489 456481005654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481005655 putative substrate translocation pore; other site 456481005656 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 456481005657 PLD-like domain; Region: PLDc_2; pfam13091 456481005658 putative active site [active] 456481005659 catalytic site [active] 456481005660 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 456481005661 PLD-like domain; Region: PLDc_2; pfam13091 456481005662 putative active site [active] 456481005663 catalytic site [active] 456481005664 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 456481005665 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 456481005666 GIY-YIG motif/motif A; other site 456481005667 active site 456481005668 catalytic site [active] 456481005669 putative DNA binding site [nucleotide binding]; other site 456481005670 metal binding site [ion binding]; metal-binding site 456481005671 UvrB/uvrC motif; Region: UVR; pfam02151 456481005672 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 456481005673 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 456481005674 active site 456481005675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481005676 dimerization interface [polypeptide binding]; other site 456481005677 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481005678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481005679 dimer interface [polypeptide binding]; other site 456481005680 putative CheW interface [polypeptide binding]; other site 456481005681 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 456481005682 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 456481005683 Catalytic site [active] 456481005684 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481005685 GAF domain; Region: GAF; pfam01590 456481005686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481005687 dimer interface [polypeptide binding]; other site 456481005688 phosphorylation site [posttranslational modification] 456481005689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481005690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005691 ATP binding site [chemical binding]; other site 456481005692 Mg2+ binding site [ion binding]; other site 456481005693 G-X-G motif; other site 456481005694 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 456481005695 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 456481005696 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 456481005697 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 456481005698 Phosphoglycerate kinase; Region: PGK; pfam00162 456481005699 substrate binding site [chemical binding]; other site 456481005700 hinge regions; other site 456481005701 ADP binding site [chemical binding]; other site 456481005702 catalytic site [active] 456481005703 triosephosphate isomerase; Provisional; Region: PRK14567 456481005704 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 456481005705 substrate binding site [chemical binding]; other site 456481005706 dimer interface [polypeptide binding]; other site 456481005707 catalytic triad [active] 456481005708 Preprotein translocase SecG subunit; Region: SecG; pfam03840 456481005709 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 456481005710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481005711 dimer interface [polypeptide binding]; other site 456481005712 phosphorylation site [posttranslational modification] 456481005713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005714 ATP binding site [chemical binding]; other site 456481005715 Mg2+ binding site [ion binding]; other site 456481005716 G-X-G motif; other site 456481005717 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481005718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481005719 active site 456481005720 phosphorylation site [posttranslational modification] 456481005721 intermolecular recognition site; other site 456481005722 dimerization interface [polypeptide binding]; other site 456481005723 PQQ-like domain; Region: PQQ_2; pfam13360 456481005724 competence damage-inducible protein A; Provisional; Region: PRK00549 456481005725 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 456481005726 putative MPT binding site; other site 456481005727 Competence-damaged protein; Region: CinA; pfam02464 456481005728 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 456481005729 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 456481005730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481005731 active site 456481005732 HIGH motif; other site 456481005733 nucleotide binding site [chemical binding]; other site 456481005734 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 456481005735 KMSK motif region; other site 456481005736 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 456481005737 tRNA binding surface [nucleotide binding]; other site 456481005738 anticodon binding site; other site 456481005739 Recombination protein O N terminal; Region: RecO_N; pfam11967 456481005740 DNA repair protein RecO; Region: reco; TIGR00613 456481005741 Recombination protein O C terminal; Region: RecO_C; pfam02565 456481005742 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 456481005743 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 456481005744 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 456481005745 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 456481005746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481005747 Zn2+ binding site [ion binding]; other site 456481005748 Mg2+ binding site [ion binding]; other site 456481005749 PhoH-like protein; Region: PhoH; pfam02562 456481005750 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 456481005751 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 456481005752 dimer interface [polypeptide binding]; other site 456481005753 anticodon binding site; other site 456481005754 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 456481005755 homodimer interface [polypeptide binding]; other site 456481005756 motif 1; other site 456481005757 active site 456481005758 motif 2; other site 456481005759 GAD domain; Region: GAD; pfam02938 456481005760 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 456481005761 active site 456481005762 motif 3; other site 456481005763 replicative DNA helicase; Region: DnaB; TIGR00665 456481005764 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 456481005765 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 456481005766 Walker A motif; other site 456481005767 ATP binding site [chemical binding]; other site 456481005768 Walker B motif; other site 456481005769 DNA binding loops [nucleotide binding] 456481005770 ribosomal protein L9; Region: L9; TIGR00158 456481005771 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 456481005772 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 456481005773 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 456481005774 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 456481005775 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 456481005776 dimer interface [polypeptide binding]; other site 456481005777 ssDNA binding site [nucleotide binding]; other site 456481005778 tetramer (dimer of dimers) interface [polypeptide binding]; other site 456481005779 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 456481005780 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 456481005781 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 456481005782 putative active site [active] 456481005783 putative metal binding site [ion binding]; other site 456481005784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481005785 binding surface 456481005786 TPR motif; other site 456481005787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005788 TPR repeat; Region: TPR_11; pfam13414 456481005789 binding surface 456481005790 TPR motif; other site 456481005791 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481005792 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 456481005793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481005794 catalytic residue [active] 456481005795 CHAT domain; Region: CHAT; cl17868 456481005796 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 456481005797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481005798 DNA binding residues [nucleotide binding] 456481005799 GTP-binding protein YchF; Reviewed; Region: PRK09601 456481005800 YchF GTPase; Region: YchF; cd01900 456481005801 G1 box; other site 456481005802 GTP/Mg2+ binding site [chemical binding]; other site 456481005803 Switch I region; other site 456481005804 G2 box; other site 456481005805 Switch II region; other site 456481005806 G3 box; other site 456481005807 G4 box; other site 456481005808 G5 box; other site 456481005809 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 456481005810 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 456481005811 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 456481005812 active site 456481005813 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 456481005814 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 456481005815 Response regulator receiver domain; Region: Response_reg; pfam00072 456481005816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481005817 active site 456481005818 phosphorylation site [posttranslational modification] 456481005819 intermolecular recognition site; other site 456481005820 dimerization interface [polypeptide binding]; other site 456481005821 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481005822 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481005823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481005824 dimer interface [polypeptide binding]; other site 456481005825 phosphorylation site [posttranslational modification] 456481005826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005827 ATP binding site [chemical binding]; other site 456481005828 Mg2+ binding site [ion binding]; other site 456481005829 G-X-G motif; other site 456481005830 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 456481005831 active site residue [active] 456481005832 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 456481005833 active site 456481005834 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 456481005835 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 456481005836 TrkA-N domain; Region: TrkA_N; pfam02254 456481005837 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 456481005838 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 456481005839 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 456481005840 ATP-grasp domain; Region: ATP-grasp_4; cl17255 456481005841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481005842 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 456481005843 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481005844 cyclase homology domain; Region: CHD; cd07302 456481005845 nucleotidyl binding site; other site 456481005846 metal binding site [ion binding]; metal-binding site 456481005847 dimer interface [polypeptide binding]; other site 456481005848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005849 binding surface 456481005850 TPR motif; other site 456481005851 flagellin; Provisional; Region: PRK12804 456481005852 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 456481005853 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 456481005854 flagellin; Provisional; Region: PRK12804 456481005855 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 456481005856 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 456481005857 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 456481005858 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 456481005859 active site 456481005860 metal binding site [ion binding]; metal-binding site 456481005861 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 456481005862 DEAD-like helicases superfamily; Region: DEXDc; smart00487 456481005863 ATP binding site [chemical binding]; other site 456481005864 Mg++ binding site [ion binding]; other site 456481005865 motif III; other site 456481005866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481005867 nucleotide binding region [chemical binding]; other site 456481005868 ATP-binding site [chemical binding]; other site 456481005869 Methyltransferase domain; Region: Methyltransf_31; pfam13847 456481005870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481005871 S-adenosylmethionine binding site [chemical binding]; other site 456481005872 TPR repeat; Region: TPR_11; pfam13414 456481005873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005874 TPR motif; other site 456481005875 binding surface 456481005876 TPR repeat; Region: TPR_11; pfam13414 456481005877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005878 binding surface 456481005879 TPR motif; other site 456481005880 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481005881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481005882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005883 binding surface 456481005884 TPR motif; other site 456481005885 TPR repeat; Region: TPR_11; pfam13414 456481005886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005887 binding surface 456481005888 TPR repeat; Region: TPR_11; pfam13414 456481005889 TPR motif; other site 456481005890 TPR repeat; Region: TPR_11; pfam13414 456481005891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481005892 TPR repeat; Region: TPR_11; pfam13414 456481005893 binding surface 456481005894 TPR motif; other site 456481005895 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 456481005896 putative RNA binding site [nucleotide binding]; other site 456481005897 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 456481005898 homopentamer interface [polypeptide binding]; other site 456481005899 active site 456481005900 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 456481005901 Uncharacterized conserved protein [Function unknown]; Region: COG1543 456481005902 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 456481005903 active site 456481005904 substrate binding site [chemical binding]; other site 456481005905 catalytic site [active] 456481005906 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 456481005907 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 456481005908 30S subunit binding site; other site 456481005909 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 456481005910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481005911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481005912 DNA binding residues [nucleotide binding] 456481005913 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 456481005914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481005915 ATP binding site [chemical binding]; other site 456481005916 Mg2+ binding site [ion binding]; other site 456481005917 G-X-G motif; other site 456481005918 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 456481005919 ATP binding site [chemical binding]; other site 456481005920 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 456481005921 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 456481005922 metal binding site 2 [ion binding]; metal-binding site 456481005923 putative DNA binding helix; other site 456481005924 metal binding site 1 [ion binding]; metal-binding site 456481005925 dimer interface [polypeptide binding]; other site 456481005926 structural Zn2+ binding site [ion binding]; other site 456481005927 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 456481005928 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 456481005929 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 456481005930 dimerization interface [polypeptide binding]; other site 456481005931 ATP binding site [chemical binding]; other site 456481005932 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 456481005933 dimerization interface [polypeptide binding]; other site 456481005934 ATP binding site [chemical binding]; other site 456481005935 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 456481005936 DNA polymerase I; Reviewed; Region: PRK05761 456481005937 DNA polymerase type-B B2 subfamily catalytic domain. Archaeal proteins that are involved in DNA replication are similar to those from eukaryotes. Some archaeal members also possess multiple family B DNA polymerases (B1, B2 and B3). So far there is no...; Region: POLBc_B2; cd05531 456481005938 active site 456481005939 metal-binding site 456481005940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481005941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 456481005942 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 456481005943 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 456481005944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481005945 AAA domain; Region: AAA_21; pfam13304 456481005946 Walker A/P-loop; other site 456481005947 ATP binding site [chemical binding]; other site 456481005948 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 456481005949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481005950 AAA domain; Region: AAA_21; pfam13304 456481005951 Walker A/P-loop; other site 456481005952 ATP binding site [chemical binding]; other site 456481005953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481005954 Walker B; other site 456481005955 D-loop; other site 456481005956 H-loop/switch region; other site 456481005957 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 456481005958 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481005959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481005960 S-adenosylmethionine binding site [chemical binding]; other site 456481005961 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 456481005962 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 456481005963 cyclase homology domain; Region: CHD; cd07302 456481005964 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481005965 nucleotidyl binding site; other site 456481005966 metal binding site [ion binding]; metal-binding site 456481005967 dimer interface [polypeptide binding]; other site 456481005968 MerT mercuric transport protein; Region: MerT; cl03578 456481005969 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 456481005970 metal-binding site [ion binding] 456481005971 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 456481005972 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 456481005973 DNA binding residues [nucleotide binding] 456481005974 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 456481005975 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 456481005976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481005977 non-specific DNA binding site [nucleotide binding]; other site 456481005978 salt bridge; other site 456481005979 sequence-specific DNA binding site [nucleotide binding]; other site 456481005980 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 456481005981 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 456481005982 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 456481005983 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 456481005984 putative active site [active] 456481005985 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 456481005986 AAA domain; Region: AAA_22; pfam13401 456481005987 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 456481005988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481005989 non-specific DNA binding site [nucleotide binding]; other site 456481005990 salt bridge; other site 456481005991 sequence-specific DNA binding site [nucleotide binding]; other site 456481005992 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 456481005993 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 456481005994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481005995 motif II; other site 456481005996 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 456481005997 Divergent AAA domain; Region: AAA_4; pfam04326 456481005998 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 456481005999 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 456481006000 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 456481006001 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 456481006002 putative active site [active] 456481006003 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 456481006004 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 456481006005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481006006 sequence-specific DNA binding site [nucleotide binding]; other site 456481006007 salt bridge; other site 456481006008 MerT mercuric transport protein; Region: MerT; cl03578 456481006009 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 456481006010 metal-binding site [ion binding] 456481006011 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 456481006012 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 456481006013 DNA binding residues [nucleotide binding] 456481006014 PIN domain; Region: PIN_3; pfam13470 456481006015 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 456481006016 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 456481006017 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 456481006018 putative active site [active] 456481006019 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 456481006020 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 456481006021 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 456481006022 PIN domain; Region: PIN_3; cl17397 456481006023 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 456481006024 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 456481006025 oligomeric interface; other site 456481006026 putative active site [active] 456481006027 homodimer interface [polypeptide binding]; other site 456481006028 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 456481006029 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481006030 non-specific DNA binding site [nucleotide binding]; other site 456481006031 salt bridge; other site 456481006032 sequence-specific DNA binding site [nucleotide binding]; other site 456481006033 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 456481006034 oxyanion hole [active] 456481006035 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 456481006036 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 456481006037 sequence-specific DNA binding site [nucleotide binding]; other site 456481006038 salt bridge; other site 456481006039 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 456481006040 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 456481006041 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 456481006042 DNA binding residues [nucleotide binding] 456481006043 hypothetical protein; Provisional; Region: PRK02237 456481006044 Winged helix-turn helix; Region: HTH_29; pfam13551 456481006045 Homeodomain-like domain; Region: HTH_23; cl17451 456481006046 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 456481006047 conserved cys residue [active] 456481006048 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 456481006049 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 456481006050 putative C-terminal domain interface [polypeptide binding]; other site 456481006051 putative GSH binding site (G-site) [chemical binding]; other site 456481006052 putative dimer interface [polypeptide binding]; other site 456481006053 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 456481006054 putative N-terminal domain interface [polypeptide binding]; other site 456481006055 putative dimer interface [polypeptide binding]; other site 456481006056 putative substrate binding pocket (H-site) [chemical binding]; other site 456481006057 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 456481006058 MepB protein; Region: MepB; cl01985 456481006059 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 456481006060 active site 456481006061 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 456481006062 active site 456481006063 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 456481006064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 456481006065 RNA binding surface [nucleotide binding]; other site 456481006066 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 456481006067 active site 456481006068 uracil binding [chemical binding]; other site 456481006069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481006070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 456481006071 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 456481006072 Walker A/P-loop; other site 456481006073 ATP binding site [chemical binding]; other site 456481006074 Q-loop/lid; other site 456481006075 ABC transporter signature motif; other site 456481006076 Walker B; other site 456481006077 D-loop; other site 456481006078 H-loop/switch region; other site 456481006079 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481006080 putative CheW interface [polypeptide binding]; other site 456481006081 Cache domain; Region: Cache_1; pfam02743 456481006082 Protein chain release factor A [Translation, ribosomal structure and biogenesis]; Region: PrfA; COG0216 456481006083 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 456481006084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481006085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481006086 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 456481006087 active site 456481006088 DinB superfamily; Region: DinB_2; pfam12867 456481006089 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 456481006090 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 456481006091 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 456481006092 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 456481006093 Ligand binding site; other site 456481006094 Putative Catalytic site; other site 456481006095 DXD motif; other site 456481006096 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481006097 anti sigma factor interaction site; other site 456481006098 regulatory phosphorylation site [posttranslational modification]; other site 456481006099 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 456481006100 Ca binding site [ion binding]; other site 456481006101 active site 456481006102 catalytic site [active] 456481006103 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 456481006104 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481006105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481006106 dimer interface [polypeptide binding]; other site 456481006107 putative CheW interface [polypeptide binding]; other site 456481006108 Uncharacterized conserved protein [Function unknown]; Region: COG1284 456481006109 Leucine rich repeat; Region: LRR_8; pfam13855 456481006110 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 456481006111 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481006112 active site 456481006113 HIGH motif; other site 456481006114 nucleotide binding site [chemical binding]; other site 456481006115 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 456481006116 active site 456481006117 KMSKS motif; other site 456481006118 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 456481006119 tRNA binding surface [nucleotide binding]; other site 456481006120 anticodon binding site; other site 456481006121 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 456481006122 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 456481006123 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481006124 anti sigma factor interaction site; other site 456481006125 regulatory phosphorylation site [posttranslational modification]; other site 456481006126 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 456481006127 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 456481006128 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 456481006129 tetramerization interface [polypeptide binding]; other site 456481006130 active site 456481006131 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 456481006132 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 456481006133 catalytic residues [active] 456481006134 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 456481006135 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006136 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006137 ligand binding site [chemical binding]; other site 456481006138 flexible hinge region; other site 456481006139 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006140 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006141 ligand binding site [chemical binding]; other site 456481006142 flexible hinge region; other site 456481006143 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481006144 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481006145 active site 456481006146 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 456481006147 ThiC-associated domain; Region: ThiC-associated; pfam13667 456481006148 ThiC family; Region: ThiC; pfam01964 456481006149 PilZ domain; Region: PilZ; pfam07238 456481006150 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 456481006151 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 456481006152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481006153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481006154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481006155 Bifunctional nuclease; Region: DNase-RNase; pfam02577 456481006156 UvrB/uvrC motif; Region: UVR; pfam02151 456481006157 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 456481006158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481006159 FeS/SAM binding site; other site 456481006160 FOG: CBS domain [General function prediction only]; Region: COG0517 456481006161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 456481006162 RNase_H superfamily; Region: RNase_H_2; pfam13482 456481006163 active site 456481006164 substrate binding site [chemical binding]; other site 456481006165 catalytic site [active] 456481006166 transaminase; Validated; Region: PRK07324 456481006167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481006168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481006169 homodimer interface [polypeptide binding]; other site 456481006170 catalytic residue [active] 456481006171 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 456481006172 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 456481006173 active site 456481006174 substrate binding site [chemical binding]; other site 456481006175 metal binding site [ion binding]; metal-binding site 456481006176 acetylornithine aminotransferase; Provisional; Region: PRK02627 456481006177 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 456481006178 inhibitor-cofactor binding pocket; inhibition site 456481006179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481006180 catalytic residue [active] 456481006181 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 456481006182 tartrate dehydrogenase; Region: TTC; TIGR02089 456481006183 Response regulator receiver domain; Region: Response_reg; pfam00072 456481006184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006185 active site 456481006186 phosphorylation site [posttranslational modification] 456481006187 intermolecular recognition site; other site 456481006188 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 456481006189 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 456481006190 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 456481006191 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 456481006192 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 456481006193 active site 456481006194 catalytic site [active] 456481006195 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 456481006196 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 456481006197 dimerization interface [polypeptide binding]; other site 456481006198 active site 456481006199 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 456481006200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481006201 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481006202 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481006203 anti sigma factor interaction site; other site 456481006204 regulatory phosphorylation site [posttranslational modification]; other site 456481006205 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 456481006206 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 456481006207 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 456481006208 metal binding site 2 [ion binding]; metal-binding site 456481006209 putative DNA binding helix; other site 456481006210 metal binding site 1 [ion binding]; metal-binding site 456481006211 dimer interface [polypeptide binding]; other site 456481006212 structural Zn2+ binding site [ion binding]; other site 456481006213 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481006214 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 456481006215 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 456481006216 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 456481006217 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 456481006218 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 456481006219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006220 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006221 ligand binding site [chemical binding]; other site 456481006222 flexible hinge region; other site 456481006223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 456481006224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006225 active site 456481006226 phosphorylation site [posttranslational modification] 456481006227 intermolecular recognition site; other site 456481006228 dimerization interface [polypeptide binding]; other site 456481006229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 456481006230 DNA binding residues [nucleotide binding] 456481006231 dimerization interface [polypeptide binding]; other site 456481006232 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481006233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481006234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481006235 dimer interface [polypeptide binding]; other site 456481006236 phosphorylation site [posttranslational modification] 456481006237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006238 ATP binding site [chemical binding]; other site 456481006239 Mg2+ binding site [ion binding]; other site 456481006240 G-X-G motif; other site 456481006241 Response regulator receiver domain; Region: Response_reg; pfam00072 456481006242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006243 active site 456481006244 phosphorylation site [posttranslational modification] 456481006245 intermolecular recognition site; other site 456481006246 dimerization interface [polypeptide binding]; other site 456481006247 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 456481006248 Zonular occludens toxin (Zot); Region: Zot; cl17485 456481006249 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 456481006250 oligomerisation interface [polypeptide binding]; other site 456481006251 mobile loop; other site 456481006252 roof hairpin; other site 456481006253 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 456481006254 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 456481006255 ring oligomerisation interface [polypeptide binding]; other site 456481006256 ATP/Mg binding site [chemical binding]; other site 456481006257 stacking interactions; other site 456481006258 hinge regions; other site 456481006259 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 456481006260 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 456481006261 oligomeric interface; other site 456481006262 putative active site [active] 456481006263 homodimer interface [polypeptide binding]; other site 456481006264 RF-1 domain; Region: RF-1; pfam00472 456481006265 antiporter inner membrane protein; Provisional; Region: PRK11670 456481006266 Domain of unknown function DUF59; Region: DUF59; pfam01883 456481006267 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 456481006268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 456481006269 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 456481006270 putative active site [active] 456481006271 putative metal binding site [ion binding]; other site 456481006272 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 456481006273 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 456481006274 E3 interaction surface; other site 456481006275 lipoyl attachment site [posttranslational modification]; other site 456481006276 aminodeoxychorismate synthase; Provisional; Region: PRK07508 456481006277 chorismate binding enzyme; Region: Chorismate_bind; cl10555 456481006278 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 456481006279 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 456481006280 substrate-cofactor binding pocket; other site 456481006281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481006282 catalytic residue [active] 456481006283 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 456481006284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481006285 Walker A motif; other site 456481006286 ATP binding site [chemical binding]; other site 456481006287 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 456481006288 Walker B motif; other site 456481006289 arginine finger; other site 456481006290 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 456481006291 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 456481006292 active site 456481006293 HslU subunit interaction site [polypeptide binding]; other site 456481006294 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481006295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006296 ATP binding site [chemical binding]; other site 456481006297 Mg2+ binding site [ion binding]; other site 456481006298 G-X-G motif; other site 456481006299 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 456481006300 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 456481006301 active site 456481006302 Int/Topo IB signature motif; other site 456481006303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481006304 binding surface 456481006305 TPR motif; other site 456481006306 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 456481006307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481006308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481006309 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 456481006310 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 456481006311 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 456481006312 putative valine binding site [chemical binding]; other site 456481006313 dimer interface [polypeptide binding]; other site 456481006314 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 456481006315 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 456481006316 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 456481006317 PYR/PP interface [polypeptide binding]; other site 456481006318 dimer interface [polypeptide binding]; other site 456481006319 TPP binding site [chemical binding]; other site 456481006320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 456481006321 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 456481006322 TPP-binding site [chemical binding]; other site 456481006323 dimer interface [polypeptide binding]; other site 456481006324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006325 binding surface 456481006326 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481006327 TPR motif; other site 456481006328 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481006329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006330 binding surface 456481006331 TPR motif; other site 456481006332 TPR repeat; Region: TPR_11; pfam13414 456481006333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006334 binding surface 456481006335 TPR motif; other site 456481006336 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481006337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006338 TPR motif; other site 456481006339 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481006340 binding surface 456481006341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481006342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481006343 putative substrate translocation pore; other site 456481006344 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 456481006345 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 456481006346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481006347 catalytic residue [active] 456481006348 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 456481006349 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 456481006350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481006351 binding surface 456481006352 TPR motif; other site 456481006353 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481006354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006355 TPR motif; other site 456481006356 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481006357 binding surface 456481006358 Methyltransferase domain; Region: Methyltransf_18; pfam12847 456481006359 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 456481006360 Part of AAA domain; Region: AAA_19; pfam13245 456481006361 Family description; Region: UvrD_C_2; pfam13538 456481006362 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 456481006363 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481006364 LemA family; Region: LemA; pfam04011 456481006365 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 456481006366 prephenate dehydrogenase; Validated; Region: PRK08507 456481006367 Chorismate mutase type II; Region: CM_2; smart00830 456481006368 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 456481006369 Prephenate dehydratase; Region: PDT; pfam00800 456481006370 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 456481006371 putative L-Phe binding site [chemical binding]; other site 456481006372 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 456481006373 ScpA/B protein; Region: ScpA_ScpB; cl00598 456481006374 Response regulator receiver domain; Region: Response_reg; pfam00072 456481006375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006376 active site 456481006377 phosphorylation site [posttranslational modification] 456481006378 intermolecular recognition site; other site 456481006379 dimerization interface [polypeptide binding]; other site 456481006380 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 456481006381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006382 active site 456481006383 phosphorylation site [posttranslational modification] 456481006384 intermolecular recognition site; other site 456481006385 dimerization interface [polypeptide binding]; other site 456481006386 CheB methylesterase; Region: CheB_methylest; pfam01339 456481006387 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 456481006388 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 456481006389 putative binding surface; other site 456481006390 active site 456481006391 P2 response regulator binding domain; Region: P2; pfam07194 456481006392 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 456481006393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006394 ATP binding site [chemical binding]; other site 456481006395 Mg2+ binding site [ion binding]; other site 456481006396 G-X-G motif; other site 456481006397 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 456481006398 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 456481006399 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 456481006400 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 456481006401 Cell division protein ZapA; Region: ZapA; pfam05164 456481006402 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 456481006403 23S rRNA binding site [nucleotide binding]; other site 456481006404 L21 binding site [polypeptide binding]; other site 456481006405 L13 binding site [polypeptide binding]; other site 456481006406 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 456481006407 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 456481006408 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 456481006409 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 456481006410 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 456481006411 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 456481006412 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 456481006413 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 456481006414 active site 456481006415 dimer interface [polypeptide binding]; other site 456481006416 motif 1; other site 456481006417 motif 2; other site 456481006418 motif 3; other site 456481006419 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 456481006420 anticodon binding site; other site 456481006421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481006422 WHG domain; Region: WHG; pfam13305 456481006423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481006424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481006425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 456481006426 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 456481006427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481006428 Walker A/P-loop; other site 456481006429 ATP binding site [chemical binding]; other site 456481006430 Q-loop/lid; other site 456481006431 ABC transporter signature motif; other site 456481006432 Walker B; other site 456481006433 D-loop; other site 456481006434 H-loop/switch region; other site 456481006435 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 456481006436 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 456481006437 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 456481006438 Nitrogen regulatory protein P-II; Region: P-II; smart00938 456481006439 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 456481006440 photolyase PhrII; Region: phr2; TIGR00591 456481006441 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 456481006442 A new structural DNA glycosylase; Region: AlkD_like; cd06561 456481006443 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 456481006444 active site 456481006445 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 456481006446 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481006447 cyclase homology domain; Region: CHD; cd07302 456481006448 nucleotidyl binding site; other site 456481006449 metal binding site [ion binding]; metal-binding site 456481006450 dimer interface [polypeptide binding]; other site 456481006451 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 456481006452 Stage II sporulation protein; Region: SpoIID; pfam08486 456481006453 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 456481006454 HDOD domain; Region: HDOD; pfam08668 456481006455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 456481006456 active site 456481006457 phosphorylation site [posttranslational modification] 456481006458 intermolecular recognition site; other site 456481006459 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481006460 cyclase homology domain; Region: CHD; cd07302 456481006461 nucleotidyl binding site; other site 456481006462 metal binding site [ion binding]; metal-binding site 456481006463 dimer interface [polypeptide binding]; other site 456481006464 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 456481006465 4Fe-4S binding domain; Region: Fer4; pfam00037 456481006466 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 456481006467 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 456481006468 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 456481006469 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 456481006470 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 456481006471 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 456481006472 NADH dehydrogenase; Region: NADHdh; cl00469 456481006473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 456481006474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481006475 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481006476 Walker A/P-loop; other site 456481006477 ATP binding site [chemical binding]; other site 456481006478 Q-loop/lid; other site 456481006479 ABC transporter signature motif; other site 456481006480 Walker B; other site 456481006481 D-loop; other site 456481006482 H-loop/switch region; other site 456481006483 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 456481006484 FtsX-like permease family; Region: FtsX; pfam02687 456481006485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 456481006486 active site 456481006487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481006488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481006489 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 456481006490 PilZ domain; Region: PilZ; pfam07238 456481006491 ornithine carbamoyltransferase; Provisional; Region: PRK14804 456481006492 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 456481006493 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 456481006494 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 456481006495 heme-binding site [chemical binding]; other site 456481006496 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 456481006497 Cache domain; Region: Cache_1; pfam02743 456481006498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481006499 dimerization interface [polypeptide binding]; other site 456481006500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481006501 dimer interface [polypeptide binding]; other site 456481006502 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 456481006503 putative CheW interface [polypeptide binding]; other site 456481006504 FecR protein; Region: FecR; pfam04773 456481006505 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 456481006506 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 456481006507 putative Cl- selectivity filter; other site 456481006508 putative pore gating glutamate residue; other site 456481006509 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481006510 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 456481006511 putative acyl-acceptor binding pocket; other site 456481006512 Response regulator receiver domain; Region: Response_reg; pfam00072 456481006513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006514 active site 456481006515 phosphorylation site [posttranslational modification] 456481006516 intermolecular recognition site; other site 456481006517 dimerization interface [polypeptide binding]; other site 456481006518 PAS fold; Region: PAS; pfam00989 456481006519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481006520 putative active site [active] 456481006521 heme pocket [chemical binding]; other site 456481006522 PAS fold; Region: PAS; pfam00989 456481006523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481006524 putative active site [active] 456481006525 heme pocket [chemical binding]; other site 456481006526 PAS domain; Region: PAS_9; pfam13426 456481006527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481006528 putative active site [active] 456481006529 heme pocket [chemical binding]; other site 456481006530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 456481006531 Histidine kinase; Region: HisKA_2; pfam07568 456481006532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006533 ATP binding site [chemical binding]; other site 456481006534 Mg2+ binding site [ion binding]; other site 456481006535 G-X-G motif; other site 456481006536 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 456481006537 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 456481006538 active site 456481006539 catalytic triad [active] 456481006540 dimer interface [polypeptide binding]; other site 456481006541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481006542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481006543 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 456481006544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 456481006545 active site 456481006546 DNA binding site [nucleotide binding] 456481006547 Int/Topo IB signature motif; other site 456481006548 recombinase A; Provisional; Region: recA; PRK09354 456481006549 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 456481006550 hexamer interface [polypeptide binding]; other site 456481006551 Walker A motif; other site 456481006552 ATP binding site [chemical binding]; other site 456481006553 Walker B motif; other site 456481006554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 456481006555 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 456481006556 active site 456481006557 catalytic tetrad [active] 456481006558 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 456481006559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481006560 Walker A motif; other site 456481006561 ATP binding site [chemical binding]; other site 456481006562 Walker B motif; other site 456481006563 arginine finger; other site 456481006564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481006565 Walker A motif; other site 456481006566 ATP binding site [chemical binding]; other site 456481006567 Walker B motif; other site 456481006568 arginine finger; other site 456481006569 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 456481006570 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481006571 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481006572 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481006573 CHASE3 domain; Region: CHASE3; pfam05227 456481006574 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481006575 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 456481006576 putative active site [active] 456481006577 heme pocket [chemical binding]; other site 456481006578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481006579 dimer interface [polypeptide binding]; other site 456481006580 phosphorylation site [posttranslational modification] 456481006581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006582 ATP binding site [chemical binding]; other site 456481006583 Mg2+ binding site [ion binding]; other site 456481006584 G-X-G motif; other site 456481006585 Response regulator receiver domain; Region: Response_reg; pfam00072 456481006586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006587 active site 456481006588 phosphorylation site [posttranslational modification] 456481006589 intermolecular recognition site; other site 456481006590 dimerization interface [polypeptide binding]; other site 456481006591 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481006592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006593 active site 456481006594 phosphorylation site [posttranslational modification] 456481006595 intermolecular recognition site; other site 456481006596 dimerization interface [polypeptide binding]; other site 456481006597 PAS fold; Region: PAS_4; pfam08448 456481006598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481006599 dimer interface [polypeptide binding]; other site 456481006600 phosphorylation site [posttranslational modification] 456481006601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006602 ATP binding site [chemical binding]; other site 456481006603 Mg2+ binding site [ion binding]; other site 456481006604 G-X-G motif; other site 456481006605 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 456481006606 Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Region: Pat_hypo_W_succinogenes_WS1459_like; cd07210 456481006607 active site 456481006608 nucleophile elbow; other site 456481006609 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 456481006610 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 456481006611 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 456481006612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481006613 motif II; other site 456481006614 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 456481006615 Peptidase family C69; Region: Peptidase_C69; cl17793 456481006616 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 456481006617 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 456481006618 MOFRL family; Region: MOFRL; pfam05161 456481006619 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481006620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481006621 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 456481006622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481006623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 456481006624 dimer interface [polypeptide binding]; other site 456481006625 phosphorylation site [posttranslational modification] 456481006626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006627 ATP binding site [chemical binding]; other site 456481006628 Mg2+ binding site [ion binding]; other site 456481006629 G-X-G motif; other site 456481006630 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481006631 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 456481006632 metal binding site 2 [ion binding]; metal-binding site 456481006633 putative DNA binding helix; other site 456481006634 structural Zn2+ binding site [ion binding]; other site 456481006635 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 456481006636 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 456481006637 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 456481006638 PaaX-like protein; Region: PaaX; pfam07848 456481006639 Predicted membrane protein [Function unknown]; Region: COG4270 456481006640 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006641 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006642 ligand binding site [chemical binding]; other site 456481006643 flexible hinge region; other site 456481006644 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006645 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006646 ligand binding site [chemical binding]; other site 456481006647 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 456481006648 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 456481006649 active site 456481006650 metal binding site [ion binding]; metal-binding site 456481006651 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 456481006652 UbiA prenyltransferase family; Region: UbiA; pfam01040 456481006653 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 456481006654 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 456481006655 active site 456481006656 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 456481006657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481006658 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 456481006659 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 456481006660 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 456481006661 putative NAD(P) binding site [chemical binding]; other site 456481006662 Haemolysin-III related; Region: HlyIII; cl03831 456481006663 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 456481006664 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 456481006665 Ca2+ binding site [ion binding]; other site 456481006666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481006667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481006668 active site 456481006669 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 456481006670 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 456481006671 active site 456481006672 FMN binding site [chemical binding]; other site 456481006673 2,4-decadienoyl-CoA binding site; other site 456481006674 catalytic residue [active] 456481006675 4Fe-4S cluster binding site [ion binding]; other site 456481006676 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 456481006677 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 456481006678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481006679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481006680 WHG domain; Region: WHG; pfam13305 456481006681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481006682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481006683 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 456481006684 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 456481006685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481006686 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 456481006687 NAD(P) binding site [chemical binding]; other site 456481006688 active site 456481006689 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 456481006690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481006691 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481006692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481006693 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 456481006694 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 456481006695 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 456481006696 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 456481006697 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 456481006698 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 456481006699 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 456481006700 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 456481006701 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 456481006702 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 456481006703 dimer interface [polypeptide binding]; other site 456481006704 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 456481006705 active site 456481006706 heme binding site [chemical binding]; other site 456481006707 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 456481006708 High potential iron-sulfur protein; Region: HIPIP; pfam01355 456481006709 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 456481006710 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 456481006711 DEAD-like helicases superfamily; Region: DEXDc; smart00487 456481006712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481006713 ATP binding site [chemical binding]; other site 456481006714 putative Mg++ binding site [ion binding]; other site 456481006715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481006716 nucleotide binding region [chemical binding]; other site 456481006717 ATP-binding site [chemical binding]; other site 456481006718 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481006719 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481006720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481006721 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481006722 cyclase homology domain; Region: CHD; cd07302 456481006723 nucleotidyl binding site; other site 456481006724 metal binding site [ion binding]; metal-binding site 456481006725 dimer interface [polypeptide binding]; other site 456481006726 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 456481006727 YceI-like domain; Region: YceI; pfam04264 456481006728 Response regulator receiver domain; Region: Response_reg; pfam00072 456481006729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006730 active site 456481006731 phosphorylation site [posttranslational modification] 456481006732 intermolecular recognition site; other site 456481006733 dimerization interface [polypeptide binding]; other site 456481006734 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481006735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481006736 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481006737 Histidine kinase; Region: His_kinase; pfam06580 456481006738 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 456481006739 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006741 ligand binding site [chemical binding]; other site 456481006742 flexible hinge region; other site 456481006743 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481006744 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006745 ligand binding site [chemical binding]; other site 456481006746 flexible hinge region; other site 456481006747 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 456481006748 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 456481006749 nucleophile elbow; other site 456481006750 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006751 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006752 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006753 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006754 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006755 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006756 FG-GAP repeat; Region: FG-GAP_2; pfam14312 456481006757 Gram-negative bacterial tonB protein; Region: TonB; cl10048 456481006758 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481006759 GAF domain; Region: GAF; cl17456 456481006760 GAF domain; Region: GAF_2; pfam13185 456481006761 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481006762 GAF domain; Region: GAF; cl17456 456481006763 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 456481006764 cyclase homology domain; Region: CHD; cd07302 456481006765 nucleotidyl binding site; other site 456481006766 metal binding site [ion binding]; metal-binding site 456481006767 dimer interface [polypeptide binding]; other site 456481006768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 456481006769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481006770 active site 456481006771 phosphorylation site [posttranslational modification] 456481006772 intermolecular recognition site; other site 456481006773 dimerization interface [polypeptide binding]; other site 456481006774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 456481006775 DNA binding residues [nucleotide binding] 456481006776 dimerization interface [polypeptide binding]; other site 456481006777 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481006778 Uncharacterized conserved protein [Function unknown]; Region: COG4938 456481006779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481006780 Walker A/P-loop; other site 456481006781 ATP binding site [chemical binding]; other site 456481006782 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 456481006783 Protein of unknown function DUF262; Region: DUF262; pfam03235 456481006784 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481006785 Esterase/lipase [General function prediction only]; Region: COG1647 456481006786 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 456481006787 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 456481006788 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 456481006789 dimerization interface [polypeptide binding]; other site 456481006790 DPS ferroxidase diiron center [ion binding]; other site 456481006791 ion pore; other site 456481006792 acyl-CoA esterase; Provisional; Region: PRK10673 456481006793 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481006794 aspartate aminotransferase; Provisional; Region: PRK05764 456481006795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481006796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481006797 homodimer interface [polypeptide binding]; other site 456481006798 catalytic residue [active] 456481006799 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 456481006800 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 456481006801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481006802 ATP binding site [chemical binding]; other site 456481006803 putative Mg++ binding site [ion binding]; other site 456481006804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481006805 nucleotide binding region [chemical binding]; other site 456481006806 ATP-binding site [chemical binding]; other site 456481006807 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 456481006808 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 456481006809 FMN binding site [chemical binding]; other site 456481006810 active site 456481006811 catalytic residues [active] 456481006812 substrate binding site [chemical binding]; other site 456481006813 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 456481006814 FHIPEP family; Region: FHIPEP; pfam00771 456481006815 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 456481006816 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 456481006817 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 456481006818 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 456481006819 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 456481006820 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 456481006821 flagellar motor switch protein; Validated; Region: PRK08119 456481006822 flagellar motor switch protein FliN; Region: fliN; TIGR02480 456481006823 Protein of unknown function (DUF971); Region: DUF971; pfam06155 456481006824 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 456481006825 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 456481006826 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 456481006827 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 456481006828 ArsC family; Region: ArsC; pfam03960 456481006829 catalytic residue [active] 456481006830 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 456481006831 hydrophobic ligand binding site; other site 456481006832 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 456481006833 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 456481006834 trimer interface [polypeptide binding]; other site 456481006835 active site 456481006836 UDP-GlcNAc binding site [chemical binding]; other site 456481006837 lipid binding site [chemical binding]; lipid-binding site 456481006838 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481006839 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481006840 ligand binding site [chemical binding]; other site 456481006841 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 456481006842 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 456481006843 Ligand binding site; other site 456481006844 Putative Catalytic site; other site 456481006845 DXD motif; other site 456481006846 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 456481006847 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 456481006848 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 456481006849 active site residue [active] 456481006850 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 456481006851 active site residue [active] 456481006852 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 456481006853 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 456481006854 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 456481006855 homodimer interface [polypeptide binding]; other site 456481006856 substrate-cofactor binding pocket; other site 456481006857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481006858 catalytic residue [active] 456481006859 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481006860 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481006861 Walker A/P-loop; other site 456481006862 ATP binding site [chemical binding]; other site 456481006863 Q-loop/lid; other site 456481006864 ABC transporter signature motif; other site 456481006865 Walker B; other site 456481006866 D-loop; other site 456481006867 H-loop/switch region; other site 456481006868 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 456481006869 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 456481006870 FtsX-like permease family; Region: FtsX; pfam02687 456481006871 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 456481006872 carboxyltransferase (CT) interaction site; other site 456481006873 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481006874 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 456481006875 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 456481006876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481006877 FeS/SAM binding site; other site 456481006878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006879 binding surface 456481006880 TPR motif; other site 456481006881 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 456481006882 TPR repeat; Region: TPR_11; pfam13414 456481006883 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 456481006884 Clp amino terminal domain; Region: Clp_N; pfam02861 456481006885 Clp amino terminal domain; Region: Clp_N; pfam02861 456481006886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481006887 Walker A motif; other site 456481006888 ATP binding site [chemical binding]; other site 456481006889 Walker B motif; other site 456481006890 arginine finger; other site 456481006891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481006892 Walker A motif; other site 456481006893 ATP binding site [chemical binding]; other site 456481006894 Walker B motif; other site 456481006895 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 456481006896 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 456481006897 ADP binding site [chemical binding]; other site 456481006898 phosphagen binding site; other site 456481006899 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481006900 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481006901 Walker A/P-loop; other site 456481006902 ATP binding site [chemical binding]; other site 456481006903 Q-loop/lid; other site 456481006904 ABC transporter signature motif; other site 456481006905 Walker B; other site 456481006906 D-loop; other site 456481006907 H-loop/switch region; other site 456481006908 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 456481006909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 456481006910 FtsX-like permease family; Region: FtsX; pfam02687 456481006911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 456481006912 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 456481006913 Mechanosensitive ion channel; Region: MS_channel; pfam00924 456481006914 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 456481006915 active site 456481006916 dimer interface [polypeptide binding]; other site 456481006917 metal binding site [ion binding]; metal-binding site 456481006918 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 456481006919 nudix motif; other site 456481006920 ribonuclease III; Reviewed; Region: rnc; PRK00102 456481006921 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 456481006922 dimerization interface [polypeptide binding]; other site 456481006923 active site 456481006924 metal binding site [ion binding]; metal-binding site 456481006925 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 456481006926 dsRNA binding site [nucleotide binding]; other site 456481006927 acyl carrier protein; Provisional; Region: acpP; PRK00982 456481006928 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 456481006929 active site residue [active] 456481006930 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 456481006931 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 456481006932 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 456481006933 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 456481006934 Nitrogen regulatory protein P-II; Region: P-II; smart00938 456481006935 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 456481006936 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 456481006937 NAD(P) binding site [chemical binding]; other site 456481006938 homotetramer interface [polypeptide binding]; other site 456481006939 homodimer interface [polypeptide binding]; other site 456481006940 active site 456481006941 putative phosphate acyltransferase; Provisional; Region: PRK05331 456481006942 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 456481006943 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 456481006944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481006945 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 456481006946 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 456481006947 RNA binding site [nucleotide binding]; other site 456481006948 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 456481006949 RNA binding site [nucleotide binding]; other site 456481006950 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481006951 RNA binding site [nucleotide binding]; other site 456481006952 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481006953 RNA binding site [nucleotide binding]; other site 456481006954 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481006955 RNA binding site [nucleotide binding]; other site 456481006956 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 456481006957 RNA binding site [nucleotide binding]; other site 456481006958 cytidylate kinase; Provisional; Region: cmk; PRK00023 456481006959 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 456481006960 active site 456481006961 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 456481006962 CMP-binding site; other site 456481006963 The sites determining sugar specificity; other site 456481006964 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481006965 GAF domain; Region: GAF_2; pfam13185 456481006966 PAS domain S-box; Region: sensory_box; TIGR00229 456481006967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481006968 putative active site [active] 456481006969 heme pocket [chemical binding]; other site 456481006970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 456481006971 Histidine kinase; Region: HisKA_2; pfam07568 456481006972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481006973 ATP binding site [chemical binding]; other site 456481006974 Mg2+ binding site [ion binding]; other site 456481006975 G-X-G motif; other site 456481006976 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 456481006977 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 456481006978 hinge; other site 456481006979 active site 456481006980 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481006981 ligand binding site [chemical binding]; other site 456481006982 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 456481006983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481006984 binding surface 456481006985 TPR motif; other site 456481006986 TPR repeat; Region: TPR_11; pfam13414 456481006987 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 456481006988 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 456481006989 TPP-binding site; other site 456481006990 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 456481006991 PYR/PP interface [polypeptide binding]; other site 456481006992 dimer interface [polypeptide binding]; other site 456481006993 TPP binding site [chemical binding]; other site 456481006994 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 456481006995 CHASE2 domain; Region: CHASE2; pfam05226 456481006996 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481006997 cyclase homology domain; Region: CHD; cd07302 456481006998 nucleotidyl binding site; other site 456481006999 metal binding site [ion binding]; metal-binding site 456481007000 dimer interface [polypeptide binding]; other site 456481007001 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 456481007002 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 456481007003 substrate binding site [chemical binding]; other site 456481007004 active site 456481007005 catalytic residues [active] 456481007006 heterodimer interface [polypeptide binding]; other site 456481007007 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 456481007008 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 456481007009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481007010 catalytic residue [active] 456481007011 prolyl-tRNA synthetase; Provisional; Region: PRK09194 456481007012 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 456481007013 dimer interface [polypeptide binding]; other site 456481007014 motif 1; other site 456481007015 active site 456481007016 motif 2; other site 456481007017 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 456481007018 putative deacylase active site [active] 456481007019 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 456481007020 active site 456481007021 motif 3; other site 456481007022 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 456481007023 anticodon binding site; other site 456481007024 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 456481007025 active site 456481007026 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 456481007027 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 456481007028 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 456481007029 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 456481007030 putative substrate binding region [chemical binding]; other site 456481007031 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 456481007032 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 456481007033 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 456481007034 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 456481007035 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 456481007036 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 456481007037 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14842 456481007038 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 456481007039 catalytic residue [active] 456481007040 putative FPP diphosphate binding site; other site 456481007041 putative FPP binding hydrophobic cleft; other site 456481007042 dimer interface [polypeptide binding]; other site 456481007043 putative IPP diphosphate binding site; other site 456481007044 ribosome recycling factor; Reviewed; Region: frr; PRK00083 456481007045 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 456481007046 hinge region; other site 456481007047 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 456481007048 putative nucleotide binding site [chemical binding]; other site 456481007049 uridine monophosphate binding site [chemical binding]; other site 456481007050 homohexameric interface [polypeptide binding]; other site 456481007051 elongation factor Ts; Reviewed; Region: tsf; PRK12332 456481007052 UBA/TS-N domain; Region: UBA; pfam00627 456481007053 Elongation factor TS; Region: EF_TS; pfam00889 456481007054 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 456481007055 rRNA interaction site [nucleotide binding]; other site 456481007056 S8 interaction site; other site 456481007057 putative laminin-1 binding site; other site 456481007058 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 456481007059 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 456481007060 active site 456481007061 homotetramer interface [polypeptide binding]; other site 456481007062 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 456481007063 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 456481007064 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 456481007065 PAS fold; Region: PAS_3; pfam08447 456481007066 PAS fold; Region: PAS_3; pfam08447 456481007067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007068 putative active site [active] 456481007069 heme pocket [chemical binding]; other site 456481007070 PAS domain S-box; Region: sensory_box; TIGR00229 456481007071 PAS domain; Region: PAS_8; pfam13188 456481007072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481007073 dimer interface [polypeptide binding]; other site 456481007074 phosphorylation site [posttranslational modification] 456481007075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481007076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007077 ATP binding site [chemical binding]; other site 456481007078 Mg2+ binding site [ion binding]; other site 456481007079 G-X-G motif; other site 456481007080 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 456481007081 putative dimer interface [polypeptide binding]; other site 456481007082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481007083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 456481007084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481007085 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 456481007086 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 456481007087 active site 456481007088 catalytic triad [active] 456481007089 oxyanion hole [active] 456481007090 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481007091 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481007092 dimer interface [polypeptide binding]; other site 456481007093 putative CheW interface [polypeptide binding]; other site 456481007094 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481007095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481007096 metal binding site [ion binding]; metal-binding site 456481007097 active site 456481007098 I-site; other site 456481007099 PilZ domain; Region: PilZ; pfam07238 456481007100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 456481007101 active site residue [active] 456481007102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 456481007103 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 456481007104 methionine sulfoxide reductase A; Provisional; Region: PRK14054 456481007105 HDOD domain; Region: HDOD; pfam08668 456481007106 UPF0126 domain; Region: UPF0126; pfam03458 456481007107 Predicted membrane protein [Function unknown]; Region: COG2860 456481007108 UPF0126 domain; Region: UPF0126; pfam03458 456481007109 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 456481007110 Strictosidine synthase; Region: Str_synth; pfam03088 456481007111 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481007112 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 456481007113 putative acyl-acceptor binding pocket; other site 456481007114 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481007115 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481007116 ligand binding site [chemical binding]; other site 456481007117 flexible hinge region; other site 456481007118 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481007119 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481007120 Cupin domain; Region: Cupin_2; pfam07883 456481007121 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 456481007122 short chain dehydrogenase; Provisional; Region: PRK06197 456481007123 putative NAD(P) binding site [chemical binding]; other site 456481007124 active site 456481007125 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 456481007126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007127 putative active site [active] 456481007128 heme pocket [chemical binding]; other site 456481007129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481007130 dimer interface [polypeptide binding]; other site 456481007131 phosphorylation site [posttranslational modification] 456481007132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007133 ATP binding site [chemical binding]; other site 456481007134 Mg2+ binding site [ion binding]; other site 456481007135 G-X-G motif; other site 456481007136 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 456481007137 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 456481007138 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 456481007139 Catalytic domain of Protein Kinases; Region: PKc; cd00180 456481007140 active site 456481007141 ATP binding site [chemical binding]; other site 456481007142 substrate binding site [chemical binding]; other site 456481007143 activation loop (A-loop); other site 456481007144 AAA ATPase domain; Region: AAA_16; pfam13191 456481007145 Predicted ATPase [General function prediction only]; Region: COG3899 456481007146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481007147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481007148 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481007149 short chain dehydrogenase; Provisional; Region: PRK06172 456481007150 classical (c) SDRs; Region: SDR_c; cd05233 456481007151 NAD(P) binding site [chemical binding]; other site 456481007152 active site 456481007153 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 456481007154 PilZ domain; Region: PilZ; pfam07238 456481007155 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 456481007156 Ligand Binding Site [chemical binding]; other site 456481007157 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 456481007158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481007159 dimer interface [polypeptide binding]; other site 456481007160 conserved gate region; other site 456481007161 putative PBP binding loops; other site 456481007162 ABC-ATPase subunit interface; other site 456481007163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481007164 dimer interface [polypeptide binding]; other site 456481007165 conserved gate region; other site 456481007166 putative PBP binding loops; other site 456481007167 ABC-ATPase subunit interface; other site 456481007168 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 456481007169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481007170 Walker A/P-loop; other site 456481007171 ATP binding site [chemical binding]; other site 456481007172 Q-loop/lid; other site 456481007173 ABC transporter signature motif; other site 456481007174 Walker B; other site 456481007175 D-loop; other site 456481007176 H-loop/switch region; other site 456481007177 TOBE domain; Region: TOBE_2; pfam08402 456481007178 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 456481007179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 456481007180 succinic semialdehyde dehydrogenase; Region: PLN02278 456481007181 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 456481007182 tetramerization interface [polypeptide binding]; other site 456481007183 NAD(P) binding site [chemical binding]; other site 456481007184 catalytic residues [active] 456481007185 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 456481007186 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 456481007187 inhibitor-cofactor binding pocket; inhibition site 456481007188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481007189 catalytic residue [active] 456481007190 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 456481007191 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 456481007192 tetrameric interface [polypeptide binding]; other site 456481007193 NAD binding site [chemical binding]; other site 456481007194 catalytic residues [active] 456481007195 substrate binding site [chemical binding]; other site 456481007196 Domain of unknown function (DUF389); Region: DUF389; pfam04087 456481007197 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 456481007198 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 456481007199 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 456481007200 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 456481007201 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481007202 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481007203 ligand binding site [chemical binding]; other site 456481007204 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 456481007205 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481007206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481007207 ABC transporter; Region: ABC_tran_2; pfam12848 456481007208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481007209 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 456481007210 dimerization interface [polypeptide binding]; other site 456481007211 active site 456481007212 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481007213 anti sigma factor interaction site; other site 456481007214 regulatory phosphorylation site [posttranslational modification]; other site 456481007215 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 456481007216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 456481007217 active site 456481007218 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 456481007219 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 456481007220 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 456481007221 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 456481007222 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 456481007223 putative active site [active] 456481007224 catalytic triad [active] 456481007225 putative dimer interface [polypeptide binding]; other site 456481007226 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 456481007227 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 456481007228 putative active site [active] 456481007229 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 456481007230 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481007231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481007232 S-adenosylmethionine binding site [chemical binding]; other site 456481007233 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481007234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007235 binding surface 456481007236 TPR motif; other site 456481007237 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 456481007238 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 456481007239 Subunit I/III interface [polypeptide binding]; other site 456481007240 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 456481007241 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 456481007242 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 456481007243 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 456481007244 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 456481007245 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 456481007246 Cytochrome c; Region: Cytochrom_C; pfam00034 456481007247 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 456481007248 Cu(I) binding site [ion binding]; other site 456481007249 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 456481007250 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 456481007251 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 456481007252 UbiA prenyltransferase family; Region: UbiA; pfam01040 456481007253 Repair protein; Region: Repair_PSII; cl01535 456481007254 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 456481007255 Repair protein; Region: Repair_PSII; pfam04536 456481007256 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007257 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481007258 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 456481007259 Citrate synthase; Region: Citrate_synt; pfam00285 456481007260 oxalacetate binding site [chemical binding]; other site 456481007261 citrylCoA binding site [chemical binding]; other site 456481007262 coenzyme A binding site [chemical binding]; other site 456481007263 catalytic triad [active] 456481007264 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481007265 anti sigma factor interaction site; other site 456481007266 regulatory phosphorylation site [posttranslational modification]; other site 456481007267 Cytochrome c; Region: Cytochrom_C; pfam00034 456481007268 TIGR01777 family protein; Region: yfcH 456481007269 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 456481007270 putative NAD(P) binding site [chemical binding]; other site 456481007271 putative active site [active] 456481007272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 456481007273 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 456481007274 metal ion-dependent adhesion site (MIDAS); other site 456481007275 DNA polymerase III PolC; Validated; Region: polC; PRK00448 456481007276 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 456481007277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481007278 active site 456481007279 AMP binding site [chemical binding]; other site 456481007280 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 456481007281 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 456481007282 active site 456481007283 nucleotide binding site [chemical binding]; other site 456481007284 HIGH motif; other site 456481007285 KMSKS motif; other site 456481007286 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 456481007287 active site 456481007288 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 456481007289 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481007290 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 456481007291 putative acyl-acceptor binding pocket; other site 456481007292 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 456481007293 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 456481007294 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 456481007295 active site 456481007296 Response regulator receiver domain; Region: Response_reg; pfam00072 456481007297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481007298 active site 456481007299 phosphorylation site [posttranslational modification] 456481007300 intermolecular recognition site; other site 456481007301 dimerization interface [polypeptide binding]; other site 456481007302 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 456481007303 substrate binding site [chemical binding]; other site 456481007304 multimerization interface [polypeptide binding]; other site 456481007305 ATP binding site [chemical binding]; other site 456481007306 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 456481007307 thiamine phosphate binding site [chemical binding]; other site 456481007308 active site 456481007309 pyrophosphate binding site [ion binding]; other site 456481007310 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 456481007311 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 456481007312 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 456481007313 active site 456481007314 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 456481007315 ligand binding site [chemical binding]; other site 456481007316 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 456481007317 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 456481007318 active site 456481007319 nucleophile elbow; other site 456481007320 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 456481007321 Protein of unknown function DUF86; Region: DUF86; cl01031 456481007322 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 456481007323 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 456481007324 YHYH protein; Region: YHYH; pfam14240 456481007325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 456481007326 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 456481007327 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 456481007328 Cu(I) binding site [ion binding]; other site 456481007329 ABC-2 type transporter; Region: ABC2_membrane; cl17235 456481007330 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 456481007331 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 456481007332 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 456481007333 Walker A/P-loop; other site 456481007334 ATP binding site [chemical binding]; other site 456481007335 Q-loop/lid; other site 456481007336 ABC transporter signature motif; other site 456481007337 Walker B; other site 456481007338 D-loop; other site 456481007339 H-loop/switch region; other site 456481007340 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 456481007341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481007342 ABC transporter; Region: ABC_tran_2; pfam12848 456481007343 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 456481007344 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 456481007345 ATP-grasp domain; Region: ATP-grasp; pfam02222 456481007346 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481007347 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481007348 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481007349 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 456481007350 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 456481007351 metal-binding site [ion binding] 456481007352 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 456481007353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481007354 motif II; other site 456481007355 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 456481007356 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 456481007357 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 456481007358 DNA binding residues [nucleotide binding] 456481007359 dimer interface [polypeptide binding]; other site 456481007360 copper binding site [ion binding]; other site 456481007361 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 456481007362 catalytic triad [active] 456481007363 Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Region: RPL43A; COG1997 456481007364 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481007365 anti sigma factor interaction site; other site 456481007366 regulatory phosphorylation site [posttranslational modification]; other site 456481007367 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481007368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481007369 active site 456481007370 phosphorylation site [posttranslational modification] 456481007371 intermolecular recognition site; other site 456481007372 dimerization interface [polypeptide binding]; other site 456481007373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481007374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007375 ATP binding site [chemical binding]; other site 456481007376 Mg2+ binding site [ion binding]; other site 456481007377 G-X-G motif; other site 456481007378 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 456481007379 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 456481007380 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 456481007381 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 456481007382 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 456481007383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481007384 motif II; other site 456481007385 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 456481007386 short chain dehydrogenase; Provisional; Region: PRK06181 456481007387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481007388 NAD(P) binding site [chemical binding]; other site 456481007389 active site 456481007390 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 456481007391 integral membrane protein; Region: integ_memb_HG; TIGR03954 456481007392 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 456481007393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481007394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481007395 putative substrate translocation pore; other site 456481007396 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 456481007397 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 456481007398 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 456481007399 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 456481007400 GXWXG protein; Region: GXWXG; pfam14231 456481007401 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 456481007402 CoA binding domain; Region: CoA_binding; cl17356 456481007403 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 456481007404 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 456481007405 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 456481007406 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 456481007407 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 456481007408 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481007409 Sulfate transporter family; Region: Sulfate_transp; pfam00916 456481007410 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 456481007411 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 456481007412 [4Fe-4S] binding site [ion binding]; other site 456481007413 molybdopterin cofactor binding site; other site 456481007414 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 456481007415 molybdopterin cofactor binding site; other site 456481007416 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 456481007417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481007418 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 456481007419 nitrite reductase subunit NirD; Provisional; Region: PRK14989 456481007420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481007421 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 456481007422 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 456481007423 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 456481007424 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 456481007425 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 456481007426 active site 456481007427 SAM binding site [chemical binding]; other site 456481007428 homodimer interface [polypeptide binding]; other site 456481007429 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 456481007430 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 456481007431 trimer interface [polypeptide binding]; other site 456481007432 dimer interface [polypeptide binding]; other site 456481007433 putative active site [active] 456481007434 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 456481007435 MPT binding site; other site 456481007436 trimer interface [polypeptide binding]; other site 456481007437 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 456481007438 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 456481007439 dimer interface [polypeptide binding]; other site 456481007440 putative functional site; other site 456481007441 putative MPT binding site; other site 456481007442 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 456481007443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481007444 putative substrate translocation pore; other site 456481007445 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 456481007446 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 456481007447 putative [Fe4-S4] binding site [ion binding]; other site 456481007448 putative molybdopterin cofactor binding site [chemical binding]; other site 456481007449 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 456481007450 putative molybdopterin cofactor binding site; other site 456481007451 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 456481007452 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 456481007453 ATP binding site [chemical binding]; other site 456481007454 substrate interface [chemical binding]; other site 456481007455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 456481007456 active site residue [active] 456481007457 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 456481007458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 456481007459 FeS/SAM binding site; other site 456481007460 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 456481007461 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 456481007462 MoaE homodimer interface [polypeptide binding]; other site 456481007463 MoaD interaction [polypeptide binding]; other site 456481007464 active site residues [active] 456481007465 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 456481007466 GTP binding site; other site 456481007467 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 456481007468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 456481007469 active site 456481007470 motif I; other site 456481007471 motif II; other site 456481007472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 456481007473 Histidine kinase; Region: HisKA_2; pfam07568 456481007474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007475 ATP binding site [chemical binding]; other site 456481007476 Mg2+ binding site [ion binding]; other site 456481007477 G-X-G motif; other site 456481007478 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 456481007479 putative active site [active] 456481007480 Zn binding site [ion binding]; other site 456481007481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481007482 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481007483 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 456481007484 MarR family; Region: MarR_2; pfam12802 456481007485 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 456481007486 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 456481007487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481007488 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 456481007489 active site 456481007490 OmpA family; Region: OmpA; pfam00691 456481007491 ligand binding site [chemical binding]; other site 456481007492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 456481007493 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481007495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 456481007496 dimer interface [polypeptide binding]; other site 456481007497 phosphorylation site [posttranslational modification] 456481007498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007499 ATP binding site [chemical binding]; other site 456481007500 Mg2+ binding site [ion binding]; other site 456481007501 G-X-G motif; other site 456481007502 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481007503 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481007504 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481007505 intermolecular salt bridges; other site 456481007506 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481007507 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 456481007508 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481007509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481007510 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 456481007511 active site residue [active] 456481007512 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 456481007513 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 456481007514 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 456481007515 catalytic loop [active] 456481007516 iron binding site [ion binding]; other site 456481007517 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213 456481007518 FAD binding pocket [chemical binding]; other site 456481007519 FAD binding motif [chemical binding]; other site 456481007520 phosphate binding motif [ion binding]; other site 456481007521 beta-alpha-beta structure motif; other site 456481007522 NAD binding pocket [chemical binding]; other site 456481007523 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 456481007524 Fatty acid desaturase; Region: FA_desaturase; pfam00487 456481007525 Di-iron ligands [ion binding]; other site 456481007526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481007527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481007528 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 456481007529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 456481007530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 456481007531 DNA binding residues [nucleotide binding] 456481007532 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 456481007533 Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368 456481007534 Thioredoxin; Region: Thioredoxin_4; pfam13462 456481007535 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 456481007536 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 456481007537 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481007538 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481007539 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481007540 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481007541 Bacterial SH3 domain; Region: SH3_3; cl17532 456481007542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007543 binding surface 456481007544 TPR motif; other site 456481007545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481007546 binding surface 456481007547 TPR motif; other site 456481007548 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481007549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481007550 DJ-1 family protein; Region: not_thiJ; TIGR01383 456481007551 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 456481007552 conserved cys residue [active] 456481007553 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 456481007554 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 456481007555 ATP binding site [chemical binding]; other site 456481007556 Mg++ binding site [ion binding]; other site 456481007557 motif III; other site 456481007558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481007559 nucleotide binding region [chemical binding]; other site 456481007560 ATP-binding site [chemical binding]; other site 456481007561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481007562 Coenzyme A binding pocket [chemical binding]; other site 456481007563 PEGA domain; Region: PEGA; pfam08308 456481007564 PEGA domain; Region: PEGA; pfam08308 456481007565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 456481007566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 456481007567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 456481007568 conserved gate region; other site 456481007569 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 456481007570 active site 456481007571 phosphorylation site [posttranslational modification] 456481007572 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 456481007573 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 456481007574 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 456481007575 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 456481007576 DXD motif; other site 456481007577 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 456481007578 flagellar motor protein MotA; Validated; Region: PRK08124 456481007579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481007580 S-adenosylmethionine binding site [chemical binding]; other site 456481007581 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 456481007582 RNA/DNA hybrid binding site [nucleotide binding]; other site 456481007583 active site 456481007584 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 456481007585 metal binding site 2 [ion binding]; metal-binding site 456481007586 putative DNA binding helix; other site 456481007587 metal binding site 1 [ion binding]; metal-binding site 456481007588 dimer interface [polypeptide binding]; other site 456481007589 structural Zn2+ binding site [ion binding]; other site 456481007590 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 456481007591 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 456481007592 active site 456481007593 NTP binding site [chemical binding]; other site 456481007594 metal binding triad [ion binding]; metal-binding site 456481007595 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 456481007596 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 456481007597 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 456481007598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481007599 dimerization interface [polypeptide binding]; other site 456481007600 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481007601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481007602 dimer interface [polypeptide binding]; other site 456481007603 putative CheW interface [polypeptide binding]; other site 456481007604 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 456481007605 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 456481007606 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 456481007607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 456481007608 nucleotide binding region [chemical binding]; other site 456481007609 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 456481007610 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 456481007611 catalytic triad [active] 456481007612 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481007613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 456481007614 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 456481007615 HDOD domain; Region: HDOD; pfam08668 456481007616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481007617 Zn2+ binding site [ion binding]; other site 456481007618 Mg2+ binding site [ion binding]; other site 456481007619 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 456481007620 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481007621 Walker A/P-loop; other site 456481007622 ATP binding site [chemical binding]; other site 456481007623 Q-loop/lid; other site 456481007624 ABC transporter signature motif; other site 456481007625 Walker B; other site 456481007626 D-loop; other site 456481007627 H-loop/switch region; other site 456481007628 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 456481007629 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 456481007630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 456481007631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 456481007632 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 456481007633 extended (e) SDRs; Region: SDR_e; cd08946 456481007634 NAD(P) binding site [chemical binding]; other site 456481007635 active site 456481007636 substrate binding site [chemical binding]; other site 456481007637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481007638 dimerization interface [polypeptide binding]; other site 456481007639 putative DNA binding site [nucleotide binding]; other site 456481007640 putative Zn2+ binding site [ion binding]; other site 456481007641 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 456481007642 Low molecular weight phosphatase family; Region: LMWPc; cd00115 456481007643 active site 456481007644 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 456481007645 arsenical-resistance protein; Region: acr3; TIGR00832 456481007646 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 456481007647 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 456481007648 putative active site [active] 456481007649 putative FMN binding site [chemical binding]; other site 456481007650 putative substrate binding site [chemical binding]; other site 456481007651 putative catalytic residue [active] 456481007652 GAF domain; Region: GAF; pfam01590 456481007653 GAF domain; Region: GAF_2; pfam13185 456481007654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481007655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481007656 metal binding site [ion binding]; metal-binding site 456481007657 active site 456481007658 I-site; other site 456481007659 PAS fold; Region: PAS_3; pfam08447 456481007660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007661 heme pocket [chemical binding]; other site 456481007662 putative active site [active] 456481007663 PAS domain; Region: PAS_9; pfam13426 456481007664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007665 putative active site [active] 456481007666 heme pocket [chemical binding]; other site 456481007667 PAS domain S-box; Region: sensory_box; TIGR00229 456481007668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007669 putative active site [active] 456481007670 heme pocket [chemical binding]; other site 456481007671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481007672 phosphorylation site [posttranslational modification] 456481007673 dimer interface [polypeptide binding]; other site 456481007674 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 456481007675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 456481007676 Coenzyme A binding pocket [chemical binding]; other site 456481007677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481007678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481007679 active site 456481007680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481007681 PGAP1-like protein; Region: PGAP1; pfam07819 456481007682 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 456481007683 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 456481007684 NADP binding site [chemical binding]; other site 456481007685 substrate binding site [chemical binding]; other site 456481007686 active site 456481007687 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 456481007688 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 456481007689 putative hydrophobic ligand binding site [chemical binding]; other site 456481007690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481007691 dimerization interface [polypeptide binding]; other site 456481007692 putative DNA binding site [nucleotide binding]; other site 456481007693 putative Zn2+ binding site [ion binding]; other site 456481007694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481007695 active site 456481007696 GAF domain; Region: GAF_2; pfam13185 456481007697 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481007698 cyclase homology domain; Region: CHD; cd07302 456481007699 nucleotidyl binding site; other site 456481007700 metal binding site [ion binding]; metal-binding site 456481007701 dimer interface [polypeptide binding]; other site 456481007702 isocitrate dehydrogenase; Validated; Region: PRK08299 456481007703 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 456481007704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481007705 S-adenosylmethionine binding site [chemical binding]; other site 456481007706 TPR repeat; Region: TPR_11; pfam13414 456481007707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007708 binding surface 456481007709 TPR motif; other site 456481007710 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481007711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007712 binding surface 456481007713 Tetratricopeptide repeat; Region: TPR_12; pfam13424 456481007714 TPR motif; other site 456481007715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007716 binding surface 456481007717 TPR motif; other site 456481007718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007719 binding surface 456481007720 TPR motif; other site 456481007721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007722 TPR motif; other site 456481007723 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481007724 binding surface 456481007725 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 456481007726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007727 binding surface 456481007728 TPR motif; other site 456481007729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007730 binding surface 456481007731 TPR motif; other site 456481007732 PEGA domain; Region: PEGA; pfam08308 456481007733 PEGA domain; Region: PEGA; pfam08308 456481007734 FecR protein; Region: FecR; pfam04773 456481007735 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 456481007736 RNA binding site [nucleotide binding]; other site 456481007737 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 456481007738 GTPase/Zn-binding domain interface [polypeptide binding]; other site 456481007739 GTP/Mg2+ binding site [chemical binding]; other site 456481007740 G4 box; other site 456481007741 G5 box; other site 456481007742 G1 box; other site 456481007743 Switch I region; other site 456481007744 G2 box; other site 456481007745 G3 box; other site 456481007746 Switch II region; other site 456481007747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 456481007748 dimer interface [polypeptide binding]; other site 456481007749 phosphorylation site [posttranslational modification] 456481007750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481007751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007752 ATP binding site [chemical binding]; other site 456481007753 Mg2+ binding site [ion binding]; other site 456481007754 G-X-G motif; other site 456481007755 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 456481007756 Fatty acid desaturase; Region: FA_desaturase; pfam00487 456481007757 Di-iron ligands [ion binding]; other site 456481007758 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 456481007759 dimer interface [polypeptide binding]; other site 456481007760 catalytic triad [active] 456481007761 peroxidatic and resolving cysteines [active] 456481007762 AAA domain; Region: AAA_23; pfam13476 456481007763 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 456481007764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 456481007765 ATP binding site [chemical binding]; other site 456481007766 Q-loop/lid; other site 456481007767 ABC transporter signature motif; other site 456481007768 Walker B; other site 456481007769 D-loop; other site 456481007770 H-loop/switch region; other site 456481007771 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 456481007772 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 456481007773 active site 456481007774 metal binding site [ion binding]; metal-binding site 456481007775 DNA binding site [nucleotide binding] 456481007776 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 456481007777 CoA-transferase family III; Region: CoA_transf_3; pfam02515 456481007778 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 456481007779 Sulfatase; Region: Sulfatase; cl17466 456481007780 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 456481007781 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481007782 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481007783 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 456481007784 putative active site [active] 456481007785 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 456481007786 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 456481007787 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 456481007788 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 456481007789 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 456481007790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481007791 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 456481007792 Putative methyltransferase; Region: Methyltransf_4; cl17290 456481007793 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481007794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481007795 S-adenosylmethionine binding site [chemical binding]; other site 456481007796 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 456481007797 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 456481007798 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 456481007799 Protein of unknown function (DUF342); Region: DUF342; pfam03961 456481007800 Transcriptional activator; Region: Transcrip_act; pfam04949 456481007801 methionine sulfoxide reductase A; Provisional; Region: PRK14054 456481007802 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 456481007803 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 456481007804 CHAT domain; Region: CHAT; pfam12770 456481007805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 456481007806 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 456481007807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481007808 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481007809 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481007810 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 456481007811 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481007812 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 456481007813 acyl-activating enzyme (AAE) consensus motif; other site 456481007814 acyl-activating enzyme (AAE) consensus motif; other site 456481007815 putative AMP binding site [chemical binding]; other site 456481007816 putative active site [active] 456481007817 putative CoA binding site [chemical binding]; other site 456481007818 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481007819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481007820 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 456481007821 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 456481007822 active site 456481007823 PHP Thumb interface [polypeptide binding]; other site 456481007824 metal binding site [ion binding]; metal-binding site 456481007825 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 456481007826 generic binding surface I; other site 456481007827 generic binding surface II; other site 456481007828 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 456481007829 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 456481007830 putative dimer interface [polypeptide binding]; other site 456481007831 active site pocket [active] 456481007832 putative cataytic base [active] 456481007833 cobalamin synthase; Reviewed; Region: cobS; PRK00235 456481007834 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 456481007835 catalytic core [active] 456481007836 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 456481007837 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 456481007838 GatB domain; Region: GatB_Yqey; smart00845 456481007839 Hemerythrin; Region: Hemerythrin; cd12107 456481007840 Fe binding site [ion binding]; other site 456481007841 Hemerythrin; Region: Hemerythrin; cd12107 456481007842 Fe binding site [ion binding]; other site 456481007843 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 456481007844 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 456481007845 NAD(P) binding site [chemical binding]; other site 456481007846 catalytic residues [active] 456481007847 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 456481007848 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007849 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481007850 cyclase homology domain; Region: CHD; cd07302 456481007851 nucleotidyl binding site; other site 456481007852 metal binding site [ion binding]; metal-binding site 456481007853 dimer interface [polypeptide binding]; other site 456481007854 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007855 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481007856 cyclase homology domain; Region: CHD; cd07302 456481007857 nucleotidyl binding site; other site 456481007858 metal binding site [ion binding]; metal-binding site 456481007859 dimer interface [polypeptide binding]; other site 456481007860 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 456481007861 FliG C-terminal domain; Region: FliG_C; pfam01706 456481007862 flagellar assembly protein H; Validated; Region: fliH; PRK06669 456481007863 Flagellar assembly protein FliH; Region: FliH; pfam02108 456481007864 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481007866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007867 ATP binding site [chemical binding]; other site 456481007868 Mg2+ binding site [ion binding]; other site 456481007869 G-X-G motif; other site 456481007870 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 456481007871 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007872 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481007873 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481007874 ligand binding site [chemical binding]; other site 456481007875 flexible hinge region; other site 456481007876 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 456481007877 putative switch regulator; other site 456481007878 non-specific DNA interactions [nucleotide binding]; other site 456481007879 DNA binding site [nucleotide binding] 456481007880 sequence specific DNA binding site [nucleotide binding]; other site 456481007881 putative cAMP binding site [chemical binding]; other site 456481007882 NnrS protein; Region: NnrS; pfam05940 456481007883 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 456481007884 metal ion-dependent adhesion site (MIDAS); other site 456481007885 MoxR-like ATPases [General function prediction only]; Region: COG0714 456481007886 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 456481007887 Walker A motif; other site 456481007888 ATP binding site [chemical binding]; other site 456481007889 Walker B motif; other site 456481007890 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 456481007891 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 456481007892 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 456481007893 Binuclear center (active site) [active] 456481007894 K-pathway; other site 456481007895 Putative proton exit pathway; other site 456481007896 Cytochrome c; Region: Cytochrom_C; pfam00034 456481007897 Cytochrome c; Region: Cytochrom_C; pfam00034 456481007898 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 456481007899 Subunit I/III interface [polypeptide binding]; other site 456481007900 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 456481007901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481007902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481007903 putative substrate translocation pore; other site 456481007904 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 456481007905 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 456481007906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007907 TPR motif; other site 456481007908 binding surface 456481007909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007910 binding surface 456481007911 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481007912 TPR motif; other site 456481007913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481007914 binding surface 456481007915 TPR motif; other site 456481007916 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 456481007917 glycogen binding site [chemical binding]; other site 456481007918 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 456481007919 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 456481007920 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 456481007921 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 456481007922 PYR/PP interface [polypeptide binding]; other site 456481007923 dimer interface [polypeptide binding]; other site 456481007924 TPP binding site [chemical binding]; other site 456481007925 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 456481007926 S-adenosylmethionine synthetase; Validated; Region: PRK05250 456481007927 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 456481007928 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 456481007929 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 456481007930 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 456481007931 putative acyl-acceptor binding pocket; other site 456481007932 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 456481007933 NADH(P)-binding; Region: NAD_binding_10; pfam13460 456481007934 NAD binding site [chemical binding]; other site 456481007935 active site 456481007936 PilZ domain; Region: PilZ; cl01260 456481007937 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481007938 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 456481007939 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 456481007940 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 456481007941 dimer interface [polypeptide binding]; other site 456481007942 ssDNA binding site [nucleotide binding]; other site 456481007943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 456481007944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007945 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481007946 putative active site [active] 456481007947 heme pocket [chemical binding]; other site 456481007948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481007949 putative active site [active] 456481007950 heme pocket [chemical binding]; other site 456481007951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481007952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481007953 ATP binding site [chemical binding]; other site 456481007954 Mg2+ binding site [ion binding]; other site 456481007955 G-X-G motif; other site 456481007956 Response regulator receiver domain; Region: Response_reg; pfam00072 456481007957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481007958 active site 456481007959 phosphorylation site [posttranslational modification] 456481007960 intermolecular recognition site; other site 456481007961 dimerization interface [polypeptide binding]; other site 456481007962 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 456481007963 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 456481007964 active site 456481007965 FMN binding site [chemical binding]; other site 456481007966 substrate binding site [chemical binding]; other site 456481007967 3Fe-4S cluster binding site [ion binding]; other site 456481007968 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481007969 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481007970 cyclase homology domain; Region: CHD; cd07302 456481007971 nucleotidyl binding site; other site 456481007972 metal binding site [ion binding]; metal-binding site 456481007973 dimer interface [polypeptide binding]; other site 456481007974 ethanolamine permease; Region: 2A0305; TIGR00908 456481007975 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 456481007976 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 456481007977 Repair protein; Region: Repair_PSII; pfam04536 456481007978 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 456481007979 hypothetical protein; Provisional; Region: PRK07758 456481007980 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 456481007981 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 456481007982 Interdomain contacts; other site 456481007983 Cytokine receptor motif; other site 456481007984 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 456481007985 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 456481007986 active site 456481007987 substrate-binding site [chemical binding]; other site 456481007988 metal-binding site [ion binding] 456481007989 ATP binding site [chemical binding]; other site 456481007990 glycogen synthase; Provisional; Region: glgA; PRK00654 456481007991 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 456481007992 ADP-binding pocket [chemical binding]; other site 456481007993 homodimer interface [polypeptide binding]; other site 456481007994 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 456481007995 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 456481007996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481007997 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 456481007998 Cupin; Region: Cupin_6; pfam12852 456481007999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481008000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 456481008001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481008002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481008003 NADH(P)-binding; Region: NAD_binding_10; pfam13460 456481008004 NAD(P) binding site [chemical binding]; other site 456481008005 active site 456481008006 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 456481008007 hypothetical protein; Provisional; Region: PRK10318 456481008008 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 456481008009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008011 Sulfatase; Region: Sulfatase; cl17466 456481008012 Transglycosylase; Region: Transgly; pfam00912 456481008013 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 456481008014 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 456481008015 MG2 domain; Region: A2M_N; pfam01835 456481008016 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 456481008017 Alpha-2-macroglobulin family; Region: A2M; pfam00207 456481008018 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 456481008019 PAS fold; Region: PAS_3; pfam08447 456481008020 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481008021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481008022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481008023 dimer interface [polypeptide binding]; other site 456481008024 phosphorylation site [posttranslational modification] 456481008025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481008026 ATP binding site [chemical binding]; other site 456481008027 Mg2+ binding site [ion binding]; other site 456481008028 G-X-G motif; other site 456481008029 Response regulator receiver domain; Region: Response_reg; pfam00072 456481008030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008031 active site 456481008032 phosphorylation site [posttranslational modification] 456481008033 intermolecular recognition site; other site 456481008034 dimerization interface [polypeptide binding]; other site 456481008035 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 456481008036 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 456481008037 catalytic residue [active] 456481008038 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 456481008039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481008040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481008041 peroxiredoxin; Region: AhpC; TIGR03137 456481008042 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 456481008043 dimer interface [polypeptide binding]; other site 456481008044 decamer (pentamer of dimers) interface [polypeptide binding]; other site 456481008045 catalytic triad [active] 456481008046 peroxidatic and resolving cysteines [active] 456481008047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 456481008048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 456481008049 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 456481008050 dimerization interface [polypeptide binding]; other site 456481008051 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481008052 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481008053 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008054 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 456481008055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008056 active site 456481008057 phosphorylation site [posttranslational modification] 456481008058 intermolecular recognition site; other site 456481008059 dimerization interface [polypeptide binding]; other site 456481008060 LytTr DNA-binding domain; Region: LytTR; pfam04397 456481008061 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 456481008062 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 456481008063 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 456481008064 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 456481008065 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 456481008066 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 456481008067 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 456481008068 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 456481008069 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481008070 Histidine kinase; Region: His_kinase; pfam06580 456481008071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 456481008072 ATP binding site [chemical binding]; other site 456481008073 Mg2+ binding site [ion binding]; other site 456481008074 G-X-G motif; other site 456481008075 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 456481008076 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 456481008077 Cu(I) binding site [ion binding]; other site 456481008078 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 456481008079 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 456481008080 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 456481008081 putative pectinesterase; Region: PLN02432; cl01911 456481008082 Right handed beta helix region; Region: Beta_helix; pfam13229 456481008083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008085 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 456481008086 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481008087 Walker A/P-loop; other site 456481008088 ATP binding site [chemical binding]; other site 456481008089 Q-loop/lid; other site 456481008090 ABC transporter signature motif; other site 456481008091 Walker B; other site 456481008092 D-loop; other site 456481008093 H-loop/switch region; other site 456481008094 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 456481008095 FtsX-like permease family; Region: FtsX; pfam02687 456481008096 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 456481008097 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 456481008098 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481008099 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 456481008100 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 456481008101 Repair protein; Region: Repair_PSII; pfam04536 456481008102 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 456481008103 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481008104 Sulfate transporter family; Region: Sulfate_transp; pfam00916 456481008105 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481008106 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481008107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 456481008108 Domain of unknown function (DUF897); Region: DUF897; pfam05982 456481008109 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 456481008110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008112 WHG domain; Region: WHG; pfam13305 456481008113 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481008114 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 456481008115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481008116 S-adenosylmethionine binding site [chemical binding]; other site 456481008117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 456481008118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 456481008119 Uncharacterized conserved protein [Function unknown]; Region: COG5439 456481008120 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 456481008121 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481008122 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481008123 ligand binding site [chemical binding]; other site 456481008124 flexible hinge region; other site 456481008125 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 456481008126 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008127 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481008128 cyclase homology domain; Region: CHD; cd07302 456481008129 nucleotidyl binding site; other site 456481008130 metal binding site [ion binding]; metal-binding site 456481008131 dimer interface [polypeptide binding]; other site 456481008132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 456481008133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008135 WHG domain; Region: WHG; pfam13305 456481008136 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 456481008137 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 456481008138 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 456481008139 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481008140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481008141 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 456481008142 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 456481008143 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 456481008144 NAD(P) binding site [chemical binding]; other site 456481008145 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 456481008146 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 456481008147 Protein of unknown function (DUF497); Region: DUF497; pfam04365 456481008148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481008149 S-adenosylmethionine binding site [chemical binding]; other site 456481008150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 456481008151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 456481008152 PemK-like protein; Region: PemK; pfam02452 456481008153 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 456481008154 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481008155 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481008156 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481008157 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481008158 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481008159 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481008160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 456481008161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 456481008162 rod shape-determining protein MreC; Provisional; Region: PRK13922 456481008163 rod shape-determining protein MreC; Region: MreC; pfam04085 456481008164 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 456481008165 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 456481008166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 456481008167 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 456481008168 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 456481008169 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 456481008170 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 456481008171 active site 456481008172 Riboflavin kinase; Region: Flavokinase; pfam01687 456481008173 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481008174 anti sigma factor interaction site; other site 456481008175 regulatory phosphorylation site [posttranslational modification]; other site 456481008176 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 456481008177 HSP70 interaction site [polypeptide binding]; other site 456481008178 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 456481008179 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 456481008180 Pirin-related protein [General function prediction only]; Region: COG1741 456481008181 Pirin; Region: Pirin; pfam02678 456481008182 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 456481008183 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 456481008184 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 456481008185 putative hydrophobic ligand binding site [chemical binding]; other site 456481008186 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 456481008187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481008188 putative substrate translocation pore; other site 456481008189 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 456481008190 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 456481008191 dimer interface [polypeptide binding]; other site 456481008192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481008193 catalytic residue [active] 456481008194 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481008195 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481008196 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 456481008197 Helix-turn-helix domain; Region: HTH_38; pfam13936 456481008198 Integrase core domain; Region: rve; pfam00665 456481008199 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 456481008200 Cytochrome c; Region: Cytochrom_C; pfam00034 456481008201 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 456481008202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481008203 acyl-activating enzyme (AAE) consensus motif; other site 456481008204 AMP binding site [chemical binding]; other site 456481008205 active site 456481008206 CoA binding site [chemical binding]; other site 456481008207 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481008208 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481008209 Outer membrane efflux protein; Region: OEP; pfam02321 456481008210 Outer membrane efflux protein; Region: OEP; pfam02321 456481008211 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 456481008212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 456481008213 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481008214 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 456481008215 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 456481008216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481008217 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 456481008218 active site 456481008219 Fatty acid desaturase; Region: FA_desaturase; pfam00487 456481008220 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 456481008221 putative di-iron ligands [ion binding]; other site 456481008222 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 456481008223 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 456481008224 FAD binding pocket [chemical binding]; other site 456481008225 FAD binding motif [chemical binding]; other site 456481008226 phosphate binding motif [ion binding]; other site 456481008227 beta-alpha-beta structure motif; other site 456481008228 NAD binding pocket [chemical binding]; other site 456481008229 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 456481008230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 456481008231 catalytic loop [active] 456481008232 iron binding site [ion binding]; other site 456481008233 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 456481008234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 456481008236 active site 456481008237 phosphorylation site [posttranslational modification] 456481008238 intermolecular recognition site; other site 456481008239 dimerization interface [polypeptide binding]; other site 456481008240 PAS domain S-box; Region: sensory_box; TIGR00229 456481008241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481008242 putative active site [active] 456481008243 heme pocket [chemical binding]; other site 456481008244 PAS domain S-box; Region: sensory_box; TIGR00229 456481008245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 456481008246 Histidine kinase; Region: HisKA_2; pfam07568 456481008247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481008248 ATP binding site [chemical binding]; other site 456481008249 Mg2+ binding site [ion binding]; other site 456481008250 G-X-G motif; other site 456481008251 TRL-like protein family; Region: TRL; pfam13146 456481008252 TRL-like protein family; Region: TRL; pfam13146 456481008253 TRL-like protein family; Region: TRL; pfam13146 456481008254 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 456481008255 active site 456481008256 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 456481008257 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 456481008258 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 456481008259 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 456481008260 putative NAD(P) binding site [chemical binding]; other site 456481008261 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481008262 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 456481008263 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 456481008264 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 456481008265 putative NAD(P) binding site [chemical binding]; other site 456481008266 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 456481008267 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 456481008268 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481008269 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481008270 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008271 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 456481008272 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 456481008273 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 456481008274 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 456481008275 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 456481008276 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 456481008277 AAA domain; Region: AAA_33; pfam13671 456481008278 AAA domain; Region: AAA_17; pfam13207 456481008279 fumarate hydratase; Reviewed; Region: fumC; PRK00485 456481008280 Class II fumarases; Region: Fumarase_classII; cd01362 456481008281 active site 456481008282 tetramer interface [polypeptide binding]; other site 456481008283 Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; Region: SRPBCC_Aha1; cd08892 456481008284 putative hydrophobic ligand binding site [chemical binding]; other site 456481008285 putative Hsp90 binding residues [polypeptide binding]; other site 456481008286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481008287 S-adenosylmethionine binding site [chemical binding]; other site 456481008288 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 456481008289 homodimer interaction site [polypeptide binding]; other site 456481008290 cofactor binding site; other site 456481008291 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 456481008292 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 456481008293 L-aspartate oxidase; Provisional; Region: PRK06175 456481008294 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 456481008295 fumarate hydratase; Provisional; Region: PRK15389 456481008296 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 456481008297 Fumarase C-terminus; Region: Fumerase_C; pfam05683 456481008298 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481008299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481008300 S-adenosylmethionine binding site [chemical binding]; other site 456481008301 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 456481008302 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 456481008303 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 456481008304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 456481008305 Soluble P-type ATPase [General function prediction only]; Region: COG4087 456481008306 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 456481008307 Outer membrane efflux protein; Region: OEP; pfam02321 456481008308 Outer membrane efflux protein; Region: OEP; pfam02321 456481008309 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 456481008310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008312 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 456481008313 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481008314 ligand binding site [chemical binding]; other site 456481008315 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 456481008316 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 456481008317 RNA binding surface [nucleotide binding]; other site 456481008318 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 456481008319 active site 456481008320 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 456481008321 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 456481008322 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481008323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481008324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481008325 dimer interface [polypeptide binding]; other site 456481008326 phosphorylation site [posttranslational modification] 456481008327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481008328 ATP binding site [chemical binding]; other site 456481008329 Mg2+ binding site [ion binding]; other site 456481008330 G-X-G motif; other site 456481008331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008332 Response regulator receiver domain; Region: Response_reg; pfam00072 456481008333 active site 456481008334 phosphorylation site [posttranslational modification] 456481008335 intermolecular recognition site; other site 456481008336 dimerization interface [polypeptide binding]; other site 456481008337 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 456481008338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008339 active site 456481008340 phosphorylation site [posttranslational modification] 456481008341 intermolecular recognition site; other site 456481008342 dimerization interface [polypeptide binding]; other site 456481008343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 456481008344 DNA binding residues [nucleotide binding] 456481008345 dimerization interface [polypeptide binding]; other site 456481008346 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 456481008347 catalytic core [active] 456481008348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 456481008349 active site 456481008350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 456481008351 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 456481008352 dimerization interface [polypeptide binding]; other site 456481008353 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481008354 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481008355 ligand binding site [chemical binding]; other site 456481008356 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 456481008357 putative acyl-acceptor binding pocket; other site 456481008358 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 456481008359 Sulfatase; Region: Sulfatase; pfam00884 456481008360 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 456481008361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 456481008362 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 456481008363 active site 456481008364 catalytic site [active] 456481008365 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 456481008366 active site 456481008367 catalytic site [active] 456481008368 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 456481008369 VanW like protein; Region: VanW; pfam04294 456481008370 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 456481008371 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 456481008372 catalytic residues [active] 456481008373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481008374 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481008375 ligand binding site [chemical binding]; other site 456481008376 flexible hinge region; other site 456481008377 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 456481008378 potential catalytic triad [active] 456481008379 conserved cys residue [active] 456481008380 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 456481008381 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 456481008382 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 456481008383 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 456481008384 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 456481008385 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 456481008386 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 456481008387 NADP binding site [chemical binding]; other site 456481008388 putative substrate binding site [chemical binding]; other site 456481008389 active site 456481008390 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 456481008391 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 456481008392 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 456481008393 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 456481008394 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 456481008395 putative NAD(P) binding site [chemical binding]; other site 456481008396 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 456481008397 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 456481008398 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 456481008399 lipoyl attachment site [posttranslational modification]; other site 456481008400 glycine dehydrogenase; Provisional; Region: PRK05367 456481008401 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 456481008402 tetramer interface [polypeptide binding]; other site 456481008403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481008404 catalytic residue [active] 456481008405 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 456481008406 tetramer interface [polypeptide binding]; other site 456481008407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481008408 catalytic residue [active] 456481008409 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 456481008410 dimer interface [polypeptide binding]; other site 456481008411 [2Fe-2S] cluster binding site [ion binding]; other site 456481008412 Cytochrome c; Region: Cytochrom_C; pfam00034 456481008413 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 456481008414 active site 456481008415 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 456481008416 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 456481008417 B12 binding site [chemical binding]; other site 456481008418 cobalt ligand [ion binding]; other site 456481008419 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 456481008420 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 456481008421 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 456481008422 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 456481008423 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 456481008424 putative acyl-acceptor binding pocket; other site 456481008425 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 456481008426 active site 456481008427 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 456481008428 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 456481008429 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 456481008430 Response regulator receiver domain; Region: Response_reg; pfam00072 456481008431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008432 active site 456481008433 phosphorylation site [posttranslational modification] 456481008434 intermolecular recognition site; other site 456481008435 dimerization interface [polypeptide binding]; other site 456481008436 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481008437 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 456481008438 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 456481008439 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 456481008440 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 456481008441 protein binding site [polypeptide binding]; other site 456481008442 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 456481008443 active site residue [active] 456481008444 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 456481008445 active site residue [active] 456481008446 alpha-glucosidase; Provisional; Region: PRK10426 456481008447 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 456481008448 putative active site [active] 456481008449 putative catalytic site [active] 456481008450 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 456481008451 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 456481008452 active site 456481008453 metal binding site [ion binding]; metal-binding site 456481008454 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 456481008455 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 456481008456 putative acyl-acceptor binding pocket; other site 456481008457 carbon storage regulator; Provisional; Region: PRK01712 456481008458 flagellar assembly protein FliW; Provisional; Region: PRK13285 456481008459 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 456481008460 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 456481008461 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 456481008462 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 456481008463 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 456481008464 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 456481008465 FlgN protein; Region: FlgN; pfam05130 456481008466 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 456481008467 Protein of unknown function (DUF962); Region: DUF962; pfam06127 456481008468 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 456481008469 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 456481008470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481008471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481008472 DNA binding residues [nucleotide binding] 456481008473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 456481008474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008475 active site 456481008476 phosphorylation site [posttranslational modification] 456481008477 intermolecular recognition site; other site 456481008478 dimerization interface [polypeptide binding]; other site 456481008479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 456481008480 DNA binding site [nucleotide binding] 456481008481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481008482 dimerization interface [polypeptide binding]; other site 456481008483 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 456481008484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481008485 dimer interface [polypeptide binding]; other site 456481008486 phosphorylation site [posttranslational modification] 456481008487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481008488 ATP binding site [chemical binding]; other site 456481008489 Mg2+ binding site [ion binding]; other site 456481008490 G-X-G motif; other site 456481008491 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 456481008492 heterotetramer interface [polypeptide binding]; other site 456481008493 active site pocket [active] 456481008494 cleavage site 456481008495 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008496 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 456481008497 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 456481008498 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 456481008499 NAD binding site [chemical binding]; other site 456481008500 putative substrate binding site 2 [chemical binding]; other site 456481008501 putative substrate binding site 1 [chemical binding]; other site 456481008502 active site 456481008503 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 456481008504 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 456481008505 ligand binding site [chemical binding]; other site 456481008506 homodimer interface [polypeptide binding]; other site 456481008507 NAD(P) binding site [chemical binding]; other site 456481008508 trimer interface B [polypeptide binding]; other site 456481008509 trimer interface A [polypeptide binding]; other site 456481008510 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 456481008511 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 456481008512 putative acyl-acceptor binding pocket; other site 456481008513 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 456481008514 active site 456481008515 histidyl-tRNA synthetase; Region: hisS; TIGR00442 456481008516 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 456481008517 dimer interface [polypeptide binding]; other site 456481008518 motif 1; other site 456481008519 active site 456481008520 motif 2; other site 456481008521 motif 3; other site 456481008522 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 456481008523 anticodon binding site; other site 456481008524 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 456481008525 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 456481008526 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 456481008527 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481008528 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481008529 ligand binding site [chemical binding]; other site 456481008530 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 456481008531 dihydropteroate synthase; Region: DHPS; TIGR01496 456481008532 substrate binding pocket [chemical binding]; other site 456481008533 dimer interface [polypeptide binding]; other site 456481008534 inhibitor binding site; inhibition site 456481008535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008536 binding surface 456481008537 TPR repeat; Region: TPR_11; pfam13414 456481008538 TPR motif; other site 456481008539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008540 TPR repeat; Region: TPR_11; pfam13414 456481008541 binding surface 456481008542 TPR motif; other site 456481008543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008544 binding surface 456481008545 TPR motif; other site 456481008546 TPR repeat; Region: TPR_11; pfam13414 456481008547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008548 binding surface 456481008549 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008550 TPR motif; other site 456481008551 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008552 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 456481008553 rare lipoprotein A; Region: rlpA; TIGR00413 456481008554 Sporulation related domain; Region: SPOR; pfam05036 456481008555 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 456481008556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481008557 dimerization interface [polypeptide binding]; other site 456481008558 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008559 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008561 binding surface 456481008562 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008563 TPR motif; other site 456481008564 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008565 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481008566 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481008567 dimer interface [polypeptide binding]; other site 456481008568 putative CheW interface [polypeptide binding]; other site 456481008569 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 456481008570 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 456481008571 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 456481008572 trimer interface [polypeptide binding]; other site 456481008573 active site 456481008574 enoyl-CoA hydratase; Provisional; Region: PRK07657 456481008575 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 456481008576 substrate binding site [chemical binding]; other site 456481008577 oxyanion hole (OAH) forming residues; other site 456481008578 trimer interface [polypeptide binding]; other site 456481008579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481008580 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 456481008581 active site 456481008582 metal binding site [ion binding]; metal-binding site 456481008583 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 456481008584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 456481008585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 456481008586 putative substrate translocation pore; other site 456481008587 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 456481008588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481008589 NAD(P) binding site [chemical binding]; other site 456481008590 active site 456481008591 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 456481008592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 456481008593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 456481008594 homodimer interface [polypeptide binding]; other site 456481008595 catalytic residue [active] 456481008596 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 456481008597 Patatin-like phospholipase; Region: Patatin; pfam01734 456481008598 active site 456481008599 nucleophile elbow; other site 456481008600 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 456481008601 Peptidase family M48; Region: Peptidase_M48; pfam01435 456481008602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481008603 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 456481008604 NAD(P) binding site [chemical binding]; other site 456481008605 active site 456481008606 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 456481008607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481008608 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481008609 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 456481008610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481008611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 456481008612 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 456481008613 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 456481008614 active site 456481008615 dimerization interface [polypeptide binding]; other site 456481008616 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 456481008617 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 456481008618 active site 456481008619 Int/Topo IB signature motif; other site 456481008620 catalytic residues [active] 456481008621 DNA binding site [nucleotide binding] 456481008622 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481008623 anti sigma factor interaction site; other site 456481008624 regulatory phosphorylation site [posttranslational modification]; other site 456481008625 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 456481008626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 456481008627 nucleotide binding site [chemical binding]; other site 456481008628 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 456481008629 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 456481008630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481008631 NAD(P) binding site [chemical binding]; other site 456481008632 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 456481008633 active site 456481008634 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 456481008635 FAD binding site [chemical binding]; other site 456481008636 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 456481008637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008638 Response regulator receiver domain; Region: Response_reg; pfam00072 456481008639 active site 456481008640 phosphorylation site [posttranslational modification] 456481008641 intermolecular recognition site; other site 456481008642 dimerization interface [polypeptide binding]; other site 456481008643 Chemotaxis phosphatase CheX; Region: CheX; cl15816 456481008644 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 456481008645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481008646 dimer interface [polypeptide binding]; other site 456481008647 phosphorylation site [posttranslational modification] 456481008648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481008649 ATP binding site [chemical binding]; other site 456481008650 Mg2+ binding site [ion binding]; other site 456481008651 G-X-G motif; other site 456481008652 Response regulator receiver domain; Region: Response_reg; pfam00072 456481008653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008654 active site 456481008655 phosphorylation site [posttranslational modification] 456481008656 intermolecular recognition site; other site 456481008657 dimerization interface [polypeptide binding]; other site 456481008658 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 456481008659 calcium binding site 1 [ion binding]; other site 456481008660 active site 456481008661 catalytic triad [active] 456481008662 calcium binding site 2 [ion binding]; other site 456481008663 calcium binding site 3 [ion binding]; other site 456481008664 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 456481008665 peptide chain release factor 1; Validated; Region: prfA; PRK00591 456481008666 PCRF domain; Region: PCRF; pfam03462 456481008667 RF-1 domain; Region: RF-1; pfam00472 456481008668 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 456481008669 active site 456481008670 catalytic triad [active] 456481008671 dimer interface [polypeptide binding]; other site 456481008672 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 456481008673 nudix motif; other site 456481008674 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 456481008675 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 456481008676 NAD(P) binding site [chemical binding]; other site 456481008677 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 456481008678 Rhomboid family; Region: Rhomboid; cl11446 456481008679 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 456481008680 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 456481008681 putative NAD(P) binding site [chemical binding]; other site 456481008682 catalytic Zn binding site [ion binding]; other site 456481008683 structural Zn binding site [ion binding]; other site 456481008684 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481008685 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008686 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 456481008687 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 456481008688 FMN binding site [chemical binding]; other site 456481008689 substrate binding site [chemical binding]; other site 456481008690 putative catalytic residue [active] 456481008691 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 456481008692 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 456481008693 FecR protein; Region: FecR; pfam04773 456481008694 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 456481008695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481008696 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 456481008697 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 456481008698 hydrophobic ligand binding site; other site 456481008699 SnoaL-like domain; Region: SnoaL_2; pfam12680 456481008700 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 456481008701 active site residue [active] 456481008702 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 456481008703 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481008704 cyclase homology domain; Region: CHD; cd07302 456481008705 nucleotidyl binding site; other site 456481008706 metal binding site [ion binding]; metal-binding site 456481008707 dimer interface [polypeptide binding]; other site 456481008708 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 456481008709 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 456481008710 active site 456481008711 HIGH motif; other site 456481008712 KMSKS motif; other site 456481008713 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 456481008714 tRNA binding surface [nucleotide binding]; other site 456481008715 anticodon binding site; other site 456481008716 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 456481008717 dimer interface [polypeptide binding]; other site 456481008718 putative tRNA-binding site [nucleotide binding]; other site 456481008719 tellurium resistance terB-like protein; Region: terB_like; cd07177 456481008720 metal binding site [ion binding]; metal-binding site 456481008721 Tim44-like domain; Region: Tim44; cl09208 456481008722 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 456481008723 Double zinc ribbon; Region: DZR; pfam12773 456481008724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481008725 S-adenosylmethionine binding site [chemical binding]; other site 456481008726 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 456481008727 putative lipid binding site [chemical binding]; other site 456481008728 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481008729 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 456481008730 active site 456481008731 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 456481008732 active site 456481008733 putative DNA-binding cleft [nucleotide binding]; other site 456481008734 dimer interface [polypeptide binding]; other site 456481008735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481008736 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 456481008737 NAD(P) binding site [chemical binding]; other site 456481008738 active site 456481008739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008741 Putative serine esterase (DUF676); Region: DUF676; pfam05057 456481008742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 456481008743 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 456481008744 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 456481008745 catalytic core [active] 456481008746 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 456481008747 putative active site [active] 456481008748 Ap4A binding site [chemical binding]; other site 456481008749 nudix motif; other site 456481008750 putative metal binding site [ion binding]; other site 456481008751 Acylphosphatase; Region: Acylphosphatase; pfam00708 456481008752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 456481008753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 456481008754 active site 456481008755 catalytic tetrad [active] 456481008756 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 456481008757 catalytic core [active] 456481008758 Phosphotransferase enzyme family; Region: APH; pfam01636 456481008759 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 456481008760 putative active site [active] 456481008761 putative substrate binding site [chemical binding]; other site 456481008762 ATP binding site [chemical binding]; other site 456481008763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 456481008764 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 456481008765 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 456481008766 active site 456481008767 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481008768 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 456481008769 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481008770 CAAX protease self-immunity; Region: Abi; pfam02517 456481008771 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 456481008772 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 456481008773 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 456481008774 active site 456481008775 Zn binding site [ion binding]; other site 456481008776 Domain of unknown function (DU1801); Region: DUF1801; cl17490 456481008777 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 456481008778 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 456481008779 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 456481008780 hydrophobic ligand binding site; other site 456481008781 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 456481008782 putative hydrophobic ligand binding site [chemical binding]; other site 456481008783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481008784 dimerization interface [polypeptide binding]; other site 456481008785 putative DNA binding site [nucleotide binding]; other site 456481008786 putative Zn2+ binding site [ion binding]; other site 456481008787 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 456481008788 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 456481008789 FMN binding site [chemical binding]; other site 456481008790 active site 456481008791 substrate binding site [chemical binding]; other site 456481008792 catalytic residue [active] 456481008793 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481008794 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481008795 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 456481008796 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481008797 Pleckstrin homology-like domain; Region: PH-like; cl17171 456481008798 PAS domain; Region: PAS_9; pfam13426 456481008799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481008800 putative active site [active] 456481008801 heme pocket [chemical binding]; other site 456481008802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481008803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481008804 dimer interface [polypeptide binding]; other site 456481008805 phosphorylation site [posttranslational modification] 456481008806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481008807 ATP binding site [chemical binding]; other site 456481008808 Mg2+ binding site [ion binding]; other site 456481008809 G-X-G motif; other site 456481008810 Pirin-related protein [General function prediction only]; Region: COG1741 456481008811 Pirin; Region: Pirin; pfam02678 456481008812 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 456481008813 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 456481008814 Cna protein B-type domain; Region: Cna_B_2; pfam13715 456481008815 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 456481008816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008818 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 456481008819 putative FMN binding site [chemical binding]; other site 456481008820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481008821 S-adenosylmethionine binding site [chemical binding]; other site 456481008822 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 456481008823 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 456481008824 putative metal binding site [ion binding]; other site 456481008825 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481008826 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481008827 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 456481008828 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 456481008829 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481008830 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481008831 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481008832 Cna protein B-type domain; Region: Cna_B_2; pfam13715 456481008833 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 456481008834 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 456481008835 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 456481008836 YceG-like family; Region: YceG; pfam02618 456481008837 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 456481008838 dimerization interface [polypeptide binding]; other site 456481008839 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 456481008840 FAD binding domain; Region: FAD_binding_4; pfam01565 456481008841 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 456481008842 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 456481008843 ArsC family; Region: ArsC; pfam03960 456481008844 putative ArsC-like catalytic residues; other site 456481008845 putative TRX-like catalytic residues [active] 456481008846 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 456481008847 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 456481008848 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 456481008849 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 456481008850 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 456481008851 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 456481008852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 456481008853 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 456481008854 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 456481008855 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 456481008856 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 456481008857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 456481008858 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 456481008859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 456481008860 Uncharacterized conserved protein [Function unknown]; Region: COG2308 456481008861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481008862 active site 456481008863 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 456481008864 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 456481008865 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 456481008866 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 456481008867 chaperone protein DnaJ; Provisional; Region: PRK14294 456481008868 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 456481008869 HSP70 interaction site [polypeptide binding]; other site 456481008870 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 456481008871 substrate binding site [polypeptide binding]; other site 456481008872 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 456481008873 Zn binding sites [ion binding]; other site 456481008874 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 456481008875 dimer interface [polypeptide binding]; other site 456481008876 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 456481008877 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 456481008878 nucleotide binding site [chemical binding]; other site 456481008879 NEF interaction site [polypeptide binding]; other site 456481008880 SBD interface [polypeptide binding]; other site 456481008881 GrpE; Region: GrpE; pfam01025 456481008882 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 456481008883 dimer interface [polypeptide binding]; other site 456481008884 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 456481008885 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 456481008886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 456481008887 DNA-binding site [nucleotide binding]; DNA binding site 456481008888 PAS domain S-box; Region: sensory_box; TIGR00229 456481008889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481008890 putative active site [active] 456481008891 heme pocket [chemical binding]; other site 456481008892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481008893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481008894 metal binding site [ion binding]; metal-binding site 456481008895 active site 456481008896 I-site; other site 456481008897 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 456481008898 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 456481008899 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 456481008900 metal binding triad; other site 456481008901 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 456481008902 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 456481008903 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 456481008904 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 456481008905 Ca binding site [ion binding]; other site 456481008906 active site 456481008907 catalytic site [active] 456481008908 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 456481008909 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481008910 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 456481008911 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 456481008912 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 456481008913 active site 1 [active] 456481008914 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 456481008915 DUF35 OB-fold domain; Region: DUF35; pfam01796 456481008916 Bacterial SH3 domain; Region: SH3_3; pfam08239 456481008917 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 456481008918 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 456481008919 oligomeric interface; other site 456481008920 putative active site [active] 456481008921 homodimer interface [polypeptide binding]; other site 456481008922 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 456481008923 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 456481008924 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 456481008925 dimer interface [polypeptide binding]; other site 456481008926 active site 456481008927 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 456481008928 4Fe-4S binding domain; Region: Fer4; pfam00037 456481008929 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 456481008930 catalytic loop [active] 456481008931 iron binding site [ion binding]; other site 456481008932 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 456481008933 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 456481008934 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 456481008935 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 456481008936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481008937 active site 456481008938 phosphorylation site [posttranslational modification] 456481008939 intermolecular recognition site; other site 456481008940 dimerization interface [polypeptide binding]; other site 456481008941 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 456481008942 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 456481008943 Tetramer interface [polypeptide binding]; other site 456481008944 active site 456481008945 FMN-binding site [chemical binding]; other site 456481008946 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 456481008947 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 456481008948 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 456481008949 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 456481008950 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 456481008951 putative active site [active] 456481008952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 456481008953 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 456481008954 active site 456481008955 catalytic residue [active] 456481008956 dimer interface [polypeptide binding]; other site 456481008957 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008959 binding surface 456481008960 TPR motif; other site 456481008961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008962 TPR motif; other site 456481008963 binding surface 456481008964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008965 binding surface 456481008966 TPR motif; other site 456481008967 TPR repeat; Region: TPR_11; pfam13414 456481008968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481008969 binding surface 456481008970 TPR motif; other site 456481008971 Tetratricopeptide repeat; Region: TPR_16; pfam13432 456481008972 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 456481008973 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 456481008974 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 456481008975 Zn binding residues [ion binding]; other site 456481008976 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 456481008977 amidase catalytic site [active] 456481008978 Zn binding residues [ion binding]; other site 456481008979 substrate binding site [chemical binding]; other site 456481008980 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 456481008981 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 456481008982 Zn binding site [ion binding]; other site 456481008983 TRL-like protein family; Region: TRL; pfam13146 456481008984 TRL-like protein family; Region: TRL; pfam13146 456481008985 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 456481008986 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 456481008987 active site 456481008988 catalytic site [active] 456481008989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 456481008990 non-specific DNA binding site [nucleotide binding]; other site 456481008991 salt bridge; other site 456481008992 sequence-specific DNA binding site [nucleotide binding]; other site 456481008993 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 456481008994 FliG C-terminal domain; Region: FliG_C; pfam01706 456481008995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481008996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481008997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 456481008998 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481008999 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481009000 PAS domain S-box; Region: sensory_box; TIGR00229 456481009001 PAS fold; Region: PAS_4; pfam08448 456481009002 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481009003 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481009004 metal binding site [ion binding]; metal-binding site 456481009005 active site 456481009006 I-site; other site 456481009007 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 456481009008 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 456481009009 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 456481009010 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 456481009011 N-terminal plug; other site 456481009012 ligand-binding site [chemical binding]; other site 456481009013 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 456481009014 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 456481009015 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 456481009016 dimerization interface [polypeptide binding]; other site 456481009017 FAD binding pocket [chemical binding]; other site 456481009018 FAD binding motif [chemical binding]; other site 456481009019 catalytic residues [active] 456481009020 NAD binding pocket [chemical binding]; other site 456481009021 phosphate binding motif [ion binding]; other site 456481009022 beta-alpha-beta structure motif; other site 456481009023 Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229 456481009024 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 456481009025 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 456481009026 metal ion-dependent adhesion site (MIDAS); other site 456481009027 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481009028 anti sigma factor interaction site; other site 456481009029 regulatory phosphorylation site [posttranslational modification]; other site 456481009030 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 456481009031 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 456481009032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481009033 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 456481009034 ATP binding site [chemical binding]; other site 456481009035 putative Mg++ binding site [ion binding]; other site 456481009036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481009037 nucleotide binding region [chemical binding]; other site 456481009038 ATP-binding site [chemical binding]; other site 456481009039 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 456481009040 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 456481009041 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 456481009042 active site 456481009043 catalytic triad [active] 456481009044 oxyanion hole [active] 456481009045 TRL-like protein family; Region: TRL; pfam13146 456481009046 TRL-like protein family; Region: TRL; pfam13146 456481009047 Bacterial Ig-like domain; Region: Big_5; pfam13205 456481009048 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 456481009049 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 456481009050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 456481009051 binding surface 456481009052 TPR motif; other site 456481009053 acetyl-CoA synthetase; Provisional; Region: PRK00174 456481009054 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 456481009055 active site 456481009056 CoA binding site [chemical binding]; other site 456481009057 acyl-activating enzyme (AAE) consensus motif; other site 456481009058 AMP binding site [chemical binding]; other site 456481009059 acetate binding site [chemical binding]; other site 456481009060 GTP cyclohydrolase I; Provisional; Region: PLN03044 456481009061 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 456481009062 homodecamer interface [polypeptide binding]; other site 456481009063 active site 456481009064 putative catalytic site residues [active] 456481009065 zinc binding site [ion binding]; other site 456481009066 GTP-CH-I/GFRP interaction surface; other site 456481009067 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 456481009068 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481009069 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 456481009070 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 456481009071 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 456481009072 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 456481009073 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 456481009074 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 456481009075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009076 S-adenosylmethionine binding site [chemical binding]; other site 456481009077 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 456481009078 nucleoside/Zn binding site; other site 456481009079 dimer interface [polypeptide binding]; other site 456481009080 catalytic motif [active] 456481009081 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14956 456481009082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481009083 Walker A motif; other site 456481009084 ATP binding site [chemical binding]; other site 456481009085 Walker B motif; other site 456481009086 arginine finger; other site 456481009087 hypothetical protein; Provisional; Region: PRK14624 456481009088 recombination protein RecR; Reviewed; Region: recR; PRK00076 456481009089 RecR protein; Region: RecR; pfam02132 456481009090 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 456481009091 putative active site [active] 456481009092 putative metal-binding site [ion binding]; other site 456481009093 tetramer interface [polypeptide binding]; other site 456481009094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 456481009095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 456481009096 substrate binding pocket [chemical binding]; other site 456481009097 membrane-bound complex binding site; other site 456481009098 hinge residues; other site 456481009099 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 456481009100 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 456481009101 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 456481009102 ligand binding site [chemical binding]; other site 456481009103 seryl-tRNA synthetase; Provisional; Region: PRK05431 456481009104 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 456481009105 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 456481009106 dimer interface [polypeptide binding]; other site 456481009107 active site 456481009108 motif 1; other site 456481009109 motif 2; other site 456481009110 motif 3; other site 456481009111 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 456481009112 active site 456481009113 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 456481009114 Peptidase family M23; Region: Peptidase_M23; pfam01551 456481009115 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 456481009116 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 456481009117 Protein of unknown function (DUF327); Region: DUF327; pfam03885 456481009118 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 456481009119 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 456481009120 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 456481009121 Walker A/P-loop; other site 456481009122 ATP binding site [chemical binding]; other site 456481009123 Q-loop/lid; other site 456481009124 ABC transporter signature motif; other site 456481009125 Walker B; other site 456481009126 D-loop; other site 456481009127 H-loop/switch region; other site 456481009128 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 456481009129 ParB-like nuclease domain; Region: ParBc; pfam02195 456481009130 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 456481009131 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009132 P-loop; other site 456481009133 Magnesium ion binding site [ion binding]; other site 456481009134 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009135 Magnesium ion binding site [ion binding]; other site 456481009136 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 456481009137 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 456481009138 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 456481009139 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 456481009140 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 456481009141 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 456481009142 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 456481009143 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 456481009144 homodimer interface [polypeptide binding]; other site 456481009145 substrate-cofactor binding pocket; other site 456481009146 catalytic residue [active] 456481009147 AAA ATPase domain; Region: AAA_16; pfam13191 456481009148 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 456481009149 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 456481009150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009151 P-loop; other site 456481009152 Magnesium ion binding site [ion binding]; other site 456481009153 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009154 Magnesium ion binding site [ion binding]; other site 456481009155 ParB-like nuclease domain; Region: ParB; smart00470 456481009156 Helix-turn-helix domain; Region: HTH_36; pfam13730 456481009157 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 456481009158 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 456481009159 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 456481009160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 456481009161 PAS domain S-box; Region: sensory_box; TIGR00229 456481009162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481009163 putative active site [active] 456481009164 heme pocket [chemical binding]; other site 456481009165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481009166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481009167 dimer interface [polypeptide binding]; other site 456481009168 phosphorylation site [posttranslational modification] 456481009169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009170 ATP binding site [chemical binding]; other site 456481009171 Mg2+ binding site [ion binding]; other site 456481009172 G-X-G motif; other site 456481009173 heat shock protein 90; Provisional; Region: PRK05218 456481009174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009175 ATP binding site [chemical binding]; other site 456481009176 Mg2+ binding site [ion binding]; other site 456481009177 G-X-G motif; other site 456481009178 Oxygen tolerance; Region: BatD; pfam13584 456481009179 von Willebrand factor type A domain; Region: VWA_2; pfam13519 456481009180 metal ion-dependent adhesion site (MIDAS); other site 456481009181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 456481009182 binding surface 456481009183 TPR motif; other site 456481009184 TPR repeat; Region: TPR_11; pfam13414 456481009185 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 456481009186 metal ion-dependent adhesion site (MIDAS); other site 456481009187 Protein of unknown function DUF58; Region: DUF58; pfam01882 456481009188 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 456481009189 metal ion-dependent adhesion site (MIDAS); other site 456481009190 MoxR-like ATPases [General function prediction only]; Region: COG0714 456481009191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 456481009192 Walker A motif; other site 456481009193 ATP binding site [chemical binding]; other site 456481009194 Walker B motif; other site 456481009195 arginine finger; other site 456481009196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 456481009197 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 456481009198 CoenzymeA binding site [chemical binding]; other site 456481009199 subunit interaction site [polypeptide binding]; other site 456481009200 PHB binding site; other site 456481009201 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481009202 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 456481009203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481009204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481009205 Low molecular weight phosphatase family; Region: LMWPc; cd00115 456481009206 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 456481009207 active site 456481009208 Protein of unknown function DUF45; Region: DUF45; pfam01863 456481009209 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 456481009210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009211 P-loop; other site 456481009212 Magnesium ion binding site [ion binding]; other site 456481009213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009214 Magnesium ion binding site [ion binding]; other site 456481009215 ParB-like nuclease domain; Region: ParB; smart00470 456481009216 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 456481009217 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 456481009218 Predicted flavoprotein [General function prediction only]; Region: COG0431 456481009219 Acyltransferase family; Region: Acyl_transf_3; pfam01757 456481009220 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 456481009221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 456481009222 ligand binding site [chemical binding]; other site 456481009223 flexible hinge region; other site 456481009224 HDOD domain; Region: HDOD; pfam08668 456481009225 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 456481009226 Zn2+ binding site [ion binding]; other site 456481009227 Mg2+ binding site [ion binding]; other site 456481009228 NADH kinase; Region: PLN02929 456481009229 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 456481009230 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 456481009231 anti sigma factor interaction site; other site 456481009232 regulatory phosphorylation site [posttranslational modification]; other site 456481009233 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 456481009234 IHF dimer interface [polypeptide binding]; other site 456481009235 IHF - DNA interface [nucleotide binding]; other site 456481009236 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 456481009237 FAD binding domain; Region: FAD_binding_4; pfam01565 456481009238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481009239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481009240 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 456481009241 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 456481009242 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 456481009243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 456481009244 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 456481009245 active site 456481009246 ArgK protein; Region: ArgK; pfam03308 456481009247 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 456481009248 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 456481009249 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 456481009250 B12 binding site [chemical binding]; other site 456481009251 cobalt ligand [ion binding]; other site 456481009252 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 456481009253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 456481009254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 456481009255 catalytic residue [active] 456481009256 Response regulator receiver domain; Region: Response_reg; pfam00072 456481009257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481009258 active site 456481009259 phosphorylation site [posttranslational modification] 456481009260 intermolecular recognition site; other site 456481009261 dimerization interface [polypeptide binding]; other site 456481009262 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 456481009263 Aspartase; Region: Aspartase; cd01357 456481009264 active sites [active] 456481009265 tetramer interface [polypeptide binding]; other site 456481009266 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 456481009267 dimer interface [polypeptide binding]; other site 456481009268 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 456481009269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481009270 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481009271 DNA binding residues [nucleotide binding] 456481009272 Family description; Region: DsbD_2; pfam13386 456481009273 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 456481009274 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 456481009275 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 456481009276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 456481009277 metal-binding site [ion binding] 456481009278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 456481009279 Soluble P-type ATPase [General function prediction only]; Region: COG4087 456481009280 FixH; Region: FixH; pfam05751 456481009281 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 456481009282 4Fe-4S binding domain; Region: Fer4_5; pfam12801 456481009283 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 456481009284 Cytochrome c; Region: Cytochrom_C; cl11414 456481009285 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 456481009286 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 456481009287 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 456481009288 Low-spin heme binding site [chemical binding]; other site 456481009289 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 456481009290 D-pathway; other site 456481009291 Putative water exit pathway; other site 456481009292 Binuclear center (active site) [active] 456481009293 K-pathway; other site 456481009294 Putative proton exit pathway; other site 456481009295 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 456481009296 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 456481009297 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 456481009298 active site 456481009299 dimer interface [polypeptide binding]; other site 456481009300 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 456481009301 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 456481009302 active site 456481009303 FMN binding site [chemical binding]; other site 456481009304 substrate binding site [chemical binding]; other site 456481009305 3Fe-4S cluster binding site [ion binding]; other site 456481009306 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 456481009307 domain interface; other site 456481009308 Repair protein; Region: Repair_PSII; pfam04536 456481009309 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 456481009310 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 456481009311 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 456481009312 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 456481009313 ADP binding site [chemical binding]; other site 456481009314 magnesium binding site [ion binding]; other site 456481009315 putative shikimate binding site; other site 456481009316 HDOD domain; Region: HDOD; pfam08668 456481009317 CheD chemotactic sensory transduction; Region: CheD; cl00810 456481009318 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 456481009319 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 456481009320 dimerization interface [polypeptide binding]; other site 456481009321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481009322 PGAP1-like protein; Region: PGAP1; pfam07819 456481009323 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481009324 active site 456481009325 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 456481009326 active site 456481009327 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 456481009328 Interdomain contacts; other site 456481009329 Cytokine receptor motif; other site 456481009330 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 456481009331 Interdomain contacts; other site 456481009332 Cytokine receptor motif; other site 456481009333 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 456481009334 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 456481009335 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 456481009336 PilZ domain; Region: PilZ; pfam07238 456481009337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 456481009338 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 456481009339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481009340 active site 456481009341 phosphorylation site [posttranslational modification] 456481009342 intermolecular recognition site; other site 456481009343 dimerization interface [polypeptide binding]; other site 456481009344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 456481009345 DNA binding residues [nucleotide binding] 456481009346 dimerization interface [polypeptide binding]; other site 456481009347 membrane ATPase/protein kinase; Provisional; Region: PRK09435 456481009348 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 456481009349 Walker A; other site 456481009350 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 456481009351 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 456481009352 active site 456481009353 substrate binding site [chemical binding]; other site 456481009354 coenzyme B12 binding site [chemical binding]; other site 456481009355 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 456481009356 B12 binding site [chemical binding]; other site 456481009357 cobalt ligand [ion binding]; other site 456481009358 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 456481009359 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 456481009360 heterodimer interface [polypeptide binding]; other site 456481009361 substrate interaction site [chemical binding]; other site 456481009362 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 456481009363 YhhN-like protein; Region: YhhN; pfam07947 456481009364 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 456481009365 diiron binding motif [ion binding]; other site 456481009366 EamA-like transporter family; Region: EamA; pfam00892 456481009367 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 456481009368 EamA-like transporter family; Region: EamA; pfam00892 456481009369 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 456481009370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481009371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 456481009372 DNA binding residues [nucleotide binding] 456481009373 Domain of unknown function DUF302; Region: DUF302; cl01364 456481009374 spermidine synthase; Provisional; Region: PRK00811 456481009375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009376 S-adenosylmethionine binding site [chemical binding]; other site 456481009377 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 456481009378 active site 456481009379 dimer interface [polypeptide binding]; other site 456481009380 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 456481009381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 456481009382 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 456481009383 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 456481009384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009385 S-adenosylmethionine binding site [chemical binding]; other site 456481009386 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 456481009387 putative hydrophobic ligand binding site [chemical binding]; other site 456481009388 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 456481009389 activation loop (A-loop); other site 456481009390 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 456481009391 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 456481009392 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 456481009393 active site 456481009394 Substrate binding site; other site 456481009395 Mg++ binding site; other site 456481009396 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 456481009397 Ligand binding site; other site 456481009398 Putative Catalytic site; other site 456481009399 DXD motif; other site 456481009400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 456481009401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481009402 NAD(P) binding site [chemical binding]; other site 456481009403 active site 456481009404 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 456481009405 active site 456481009406 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 456481009407 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 456481009408 protein binding site [polypeptide binding]; other site 456481009409 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 456481009410 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 456481009411 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 456481009412 protein binding site [polypeptide binding]; other site 456481009413 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 456481009414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009415 ATP binding site [chemical binding]; other site 456481009416 Mg2+ binding site [ion binding]; other site 456481009417 G-X-G motif; other site 456481009418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 456481009419 active site 456481009420 heat shock protein HtpX; Provisional; Region: PRK05457 456481009421 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 456481009422 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 456481009423 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 456481009424 NAD(P) binding site [chemical binding]; other site 456481009425 homodimer interface [polypeptide binding]; other site 456481009426 substrate binding site [chemical binding]; other site 456481009427 active site 456481009428 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 456481009429 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 456481009430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481009431 ATP binding site [chemical binding]; other site 456481009432 putative Mg++ binding site [ion binding]; other site 456481009433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481009434 nucleotide binding region [chemical binding]; other site 456481009435 ATP-binding site [chemical binding]; other site 456481009436 Helicase associated domain (HA2); Region: HA2; pfam04408 456481009437 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 456481009438 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481009439 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 456481009440 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 456481009441 DNA binding site [nucleotide binding] 456481009442 active site 456481009443 YhhN-like protein; Region: YhhN; cl01505 456481009444 Integrase core domain; Region: rve; pfam00665 456481009445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 456481009446 dimerization interface [polypeptide binding]; other site 456481009447 FecR protein; Region: FecR; pfam04773 456481009448 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 456481009449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 456481009450 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 456481009451 DNA binding site [nucleotide binding] 456481009452 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 456481009453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 456481009454 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 456481009455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481009456 dimerization interface [polypeptide binding]; other site 456481009457 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 456481009458 cyclase homology domain; Region: CHD; cd07302 456481009459 nucleotidyl binding site; other site 456481009460 metal binding site [ion binding]; metal-binding site 456481009461 dimer interface [polypeptide binding]; other site 456481009462 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 456481009463 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 456481009464 dimer interface [polypeptide binding]; other site 456481009465 decamer (pentamer of dimers) interface [polypeptide binding]; other site 456481009466 catalytic triad [active] 456481009467 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 456481009468 Protein of unknown function, DUF547; Region: DUF547; pfam04784 456481009469 Predicted esterase [General function prediction only]; Region: COG0400 456481009470 Serine hydrolase (FSH1); Region: FSH1; pfam03959 456481009471 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 456481009472 active site 456481009473 DNA polymerase IV; Validated; Region: PRK02406 456481009474 DNA binding site [nucleotide binding] 456481009475 Response regulator receiver domain; Region: Response_reg; pfam00072 456481009476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481009477 active site 456481009478 phosphorylation site [posttranslational modification] 456481009479 intermolecular recognition site; other site 456481009480 dimerization interface [polypeptide binding]; other site 456481009481 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481009482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481009483 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 456481009484 putative active site [active] 456481009485 heme pocket [chemical binding]; other site 456481009486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481009487 putative active site [active] 456481009488 heme pocket [chemical binding]; other site 456481009489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481009490 dimer interface [polypeptide binding]; other site 456481009491 phosphorylation site [posttranslational modification] 456481009492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009493 ATP binding site [chemical binding]; other site 456481009494 Mg2+ binding site [ion binding]; other site 456481009495 G-X-G motif; other site 456481009496 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 456481009497 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 456481009498 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 456481009499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009500 S-adenosylmethionine binding site [chemical binding]; other site 456481009501 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 456481009502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 456481009503 AMP binding site [chemical binding]; other site 456481009504 active site 456481009505 acyl-activating enzyme (AAE) consensus motif; other site 456481009506 CoA binding site [chemical binding]; other site 456481009507 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 456481009508 photoactive yellow protein; Region: photo_yellow; TIGR02373 456481009509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481009510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481009511 dimer interface [polypeptide binding]; other site 456481009512 putative CheW interface [polypeptide binding]; other site 456481009513 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 456481009514 CoenzymeA binding site [chemical binding]; other site 456481009515 subunit interaction site [polypeptide binding]; other site 456481009516 PHB binding site; other site 456481009517 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 456481009518 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 456481009519 Sodium Bile acid symporter family; Region: SBF; pfam01758 456481009520 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 456481009521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 456481009522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 456481009523 catalytic residue [active] 456481009524 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 456481009525 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 456481009526 active site 456481009527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 456481009528 dimer interface [polypeptide binding]; other site 456481009529 substrate binding site [chemical binding]; other site 456481009530 catalytic residues [active] 456481009531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 456481009532 PGAP1-like protein; Region: PGAP1; pfam07819 456481009533 nitrilase; Region: PLN02798 456481009534 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 456481009535 putative active site [active] 456481009536 catalytic triad [active] 456481009537 dimer interface [polypeptide binding]; other site 456481009538 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 456481009539 homohexameric interface [polypeptide binding]; other site 456481009540 feedback inhibition sensing region; other site 456481009541 nucleotide binding site [chemical binding]; other site 456481009542 N-acetyl-L-glutamate binding site [chemical binding]; other site 456481009543 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481009544 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 456481009545 GAF domain; Region: GAF; pfam01590 456481009546 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 456481009547 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481009548 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 456481009549 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 456481009550 Outer membrane efflux protein; Region: OEP; pfam02321 456481009551 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 456481009552 6-phosphofructokinase; Region: PLN02884 456481009553 active site 456481009554 ADP/pyrophosphate binding site [chemical binding]; other site 456481009555 dimerization interface [polypeptide binding]; other site 456481009556 allosteric effector site; other site 456481009557 fructose-1,6-bisphosphate binding site; other site 456481009558 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481009559 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 456481009560 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 456481009561 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 456481009562 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 456481009563 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 456481009564 substrate binding pocket [chemical binding]; other site 456481009565 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 456481009566 B12 binding site [chemical binding]; other site 456481009567 cobalt ligand [ion binding]; other site 456481009568 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 456481009569 Ferredoxin [Energy production and conversion]; Region: COG1146 456481009570 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 456481009571 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 456481009572 homotetramer interface [polypeptide binding]; other site 456481009573 ligand binding site [chemical binding]; other site 456481009574 catalytic site [active] 456481009575 NAD binding site [chemical binding]; other site 456481009576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481009577 dimerization interface [polypeptide binding]; other site 456481009578 putative DNA binding site [nucleotide binding]; other site 456481009579 putative Zn2+ binding site [ion binding]; other site 456481009580 Methyltransferase domain; Region: Methyltransf_31; pfam13847 456481009581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009582 S-adenosylmethionine binding site [chemical binding]; other site 456481009583 Cache domain; Region: Cache_1; pfam02743 456481009584 HAMP domain; Region: HAMP; pfam00672 456481009585 dimerization interface [polypeptide binding]; other site 456481009586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481009587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481009588 putative CheW interface [polypeptide binding]; other site 456481009589 dimer interface [polypeptide binding]; other site 456481009590 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 456481009591 EamA-like transporter family; Region: EamA; pfam00892 456481009592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 456481009593 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 456481009594 active site 456481009595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481009596 dimerization interface [polypeptide binding]; other site 456481009597 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481009598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481009599 dimer interface [polypeptide binding]; other site 456481009600 putative CheW interface [polypeptide binding]; other site 456481009601 Cache domain; Region: Cache_1; pfam02743 456481009602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 456481009603 dimerization interface [polypeptide binding]; other site 456481009604 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481009605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481009606 dimer interface [polypeptide binding]; other site 456481009607 putative CheW interface [polypeptide binding]; other site 456481009608 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 456481009609 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 456481009610 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 456481009611 protein binding site [polypeptide binding]; other site 456481009612 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 456481009613 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 456481009614 oligomer interface [polypeptide binding]; other site 456481009615 metal binding site [ion binding]; metal-binding site 456481009616 metal binding site [ion binding]; metal-binding site 456481009617 putative Cl binding site [ion binding]; other site 456481009618 aspartate ring; other site 456481009619 basic sphincter; other site 456481009620 hydrophobic gate; other site 456481009621 periplasmic entrance; other site 456481009622 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 456481009623 classical (c) SDRs; Region: SDR_c; cd05233 456481009624 NAD(P) binding site [chemical binding]; other site 456481009625 active site 456481009626 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 456481009627 classical (c) SDRs; Region: SDR_c; cd05233 456481009628 NAD(P) binding site [chemical binding]; other site 456481009629 active site 456481009630 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 456481009631 intersubunit interface [polypeptide binding]; other site 456481009632 active site 456481009633 Zn2+ binding site [ion binding]; other site 456481009634 elongation factor P; Validated; Region: PRK00529 456481009635 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 456481009636 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 456481009637 RNA binding site [nucleotide binding]; other site 456481009638 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 456481009639 RNA binding site [nucleotide binding]; other site 456481009640 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 456481009641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 456481009642 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 456481009643 metal binding triad [ion binding]; metal-binding site 456481009644 methionine sulfoxide reductase B; Provisional; Region: PRK00222 456481009645 SelR domain; Region: SelR; pfam01641 456481009646 GAF domain; Region: GAF; pfam01590 456481009647 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 456481009648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481009649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481009650 dimer interface [polypeptide binding]; other site 456481009651 phosphorylation site [posttranslational modification] 456481009652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009653 ATP binding site [chemical binding]; other site 456481009654 Mg2+ binding site [ion binding]; other site 456481009655 G-X-G motif; other site 456481009656 Response regulator receiver domain; Region: Response_reg; pfam00072 456481009657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481009658 active site 456481009659 phosphorylation site [posttranslational modification] 456481009660 intermolecular recognition site; other site 456481009661 dimerization interface [polypeptide binding]; other site 456481009662 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 456481009663 DEAD-like helicases superfamily; Region: DEXDc; smart00487 456481009664 ATP binding site [chemical binding]; other site 456481009665 Mg++ binding site [ion binding]; other site 456481009666 motif III; other site 456481009667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 456481009668 nucleotide binding region [chemical binding]; other site 456481009669 ATP-binding site [chemical binding]; other site 456481009670 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 456481009671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009672 S-adenosylmethionine binding site [chemical binding]; other site 456481009673 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 456481009674 short chain dehydrogenase; Provisional; Region: PRK06181 456481009675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 456481009676 NAD(P) binding site [chemical binding]; other site 456481009677 active site 456481009678 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 456481009679 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 456481009680 putative NAD(P) binding site [chemical binding]; other site 456481009681 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 456481009682 putative active site [active] 456481009683 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 456481009684 Bacterial SH3 domain homologues; Region: SH3b; smart00287 456481009685 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 456481009686 active site 456481009687 nucleophile elbow; other site 456481009688 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 456481009689 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 456481009690 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481009691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 456481009692 Bacterial SH3 domain; Region: SH3_3; pfam08239 456481009693 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 456481009694 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 456481009695 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 456481009696 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 456481009697 motif 1; other site 456481009698 dimer interface [polypeptide binding]; other site 456481009699 active site 456481009700 motif 2; other site 456481009701 motif 3; other site 456481009702 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 456481009703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 456481009704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481009705 active site 456481009706 phosphorylation site [posttranslational modification] 456481009707 intermolecular recognition site; other site 456481009708 dimerization interface [polypeptide binding]; other site 456481009709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 456481009710 DNA binding site [nucleotide binding] 456481009711 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 456481009712 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 456481009713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 456481009714 dimerization interface [polypeptide binding]; other site 456481009715 putative DNA binding site [nucleotide binding]; other site 456481009716 putative Zn2+ binding site [ion binding]; other site 456481009717 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 456481009718 hydrophobic ligand binding site; other site 456481009719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 456481009720 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 456481009721 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 456481009722 DoxX-like family; Region: DoxX_2; pfam13564 456481009723 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 456481009724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 456481009725 Methyltransferase domain; Region: Methyltransf_23; pfam13489 456481009726 S-adenosylmethionine binding site [chemical binding]; other site 456481009727 aconitate hydratase; Validated; Region: PRK07229 456481009728 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 456481009729 substrate binding site [chemical binding]; other site 456481009730 ligand binding site [chemical binding]; other site 456481009731 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 456481009732 substrate binding site [chemical binding]; other site 456481009733 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 456481009734 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 456481009735 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 456481009736 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 456481009737 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 456481009738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 456481009739 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481009740 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 456481009741 homodimer interface [polypeptide binding]; other site 456481009742 metal binding site [ion binding]; metal-binding site 456481009743 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 456481009744 Kelch domain; Region: Kelch; smart00612 456481009745 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 456481009746 Kelch motif; Region: Kelch_6; pfam13964 456481009747 Galactose oxidase, central domain; Region: Kelch_3; cl02701 456481009748 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 456481009749 Kelch domain; Region: Kelch; smart00612 456481009750 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 456481009751 Galactose oxidase, central domain; Region: Kelch_3; cl02701 456481009752 Caspase domain; Region: Peptidase_C14; pfam00656 456481009753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 456481009754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 456481009755 dimer interface [polypeptide binding]; other site 456481009756 putative CheW interface [polypeptide binding]; other site 456481009757 Pirin; Region: Pirin; pfam02678 456481009758 Pirin-related protein [General function prediction only]; Region: COG1741 456481009759 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 456481009760 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 456481009761 Active site serine [active] 456481009762 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 456481009763 active site clefts [active] 456481009764 zinc binding site [ion binding]; other site 456481009765 dimer interface [polypeptide binding]; other site 456481009766 Domain of unknown function (DUF897); Region: DUF897; cl01312 456481009767 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 456481009768 Surface antigen; Region: Bac_surface_Ag; pfam01103 456481009769 pyruvate kinase; Provisional; Region: PRK05826 456481009770 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 456481009771 domain interfaces; other site 456481009772 active site 456481009773 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 456481009774 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 456481009775 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 456481009776 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 456481009777 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009778 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 456481009779 P-loop; other site 456481009780 Magnesium ion binding site [ion binding]; other site 456481009781 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 456481009782 Magnesium ion binding site [ion binding]; other site 456481009783 ParB-like nuclease domain; Region: ParB; smart00470 456481009784 Helix-turn-helix domain; Region: HTH_36; pfam13730 456481009785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481009786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481009787 WHG domain; Region: WHG; pfam13305 456481009788 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 456481009789 CoenzymeA binding site [chemical binding]; other site 456481009790 subunit interaction site [polypeptide binding]; other site 456481009791 PHB binding site; other site 456481009792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481009793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481009794 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 456481009795 Uncharacterized conserved protein [Function unknown]; Region: COG3422 456481009796 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 456481009797 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 456481009798 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 456481009799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 456481009800 Histidine kinase; Region: HisKA_2; pfam07568 456481009801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009802 ATP binding site [chemical binding]; other site 456481009803 Mg2+ binding site [ion binding]; other site 456481009804 G-X-G motif; other site 456481009805 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 456481009806 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 456481009807 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 456481009808 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 456481009809 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 456481009810 Walker A/P-loop; other site 456481009811 ATP binding site [chemical binding]; other site 456481009812 Q-loop/lid; other site 456481009813 ABC transporter signature motif; other site 456481009814 Walker B; other site 456481009815 D-loop; other site 456481009816 H-loop/switch region; other site 456481009817 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 456481009818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 456481009819 ABC-ATPase subunit interface; other site 456481009820 dimer interface [polypeptide binding]; other site 456481009821 putative PBP binding regions; other site 456481009822 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 456481009823 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 456481009824 putative hemin binding site; other site 456481009825 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 456481009826 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 456481009827 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 456481009828 N-terminal plug; other site 456481009829 ligand-binding site [chemical binding]; other site 456481009830 AAA domain; Region: AAA_30; pfam13604 456481009831 AAA domain; Region: AAA_11; pfam13086 456481009832 Family description; Region: UvrD_C_2; pfam13538 456481009833 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 456481009834 Family description; Region: UvrD_C_2; pfam13538 456481009835 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 456481009836 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 456481009837 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 456481009838 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 456481009839 Helix-turn-helix domain; Region: HTH_18; pfam12833 456481009840 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 456481009841 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 456481009842 Integrase core domain; Region: rve; pfam00665 456481009843 outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327 456481009844 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 456481009845 Predicted helicase [General function prediction only]; Region: COG4889 456481009846 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 456481009847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 456481009848 ATP binding site [chemical binding]; other site 456481009849 putative Mg++ binding site [ion binding]; other site 456481009850 helicase superfamily c-terminal domain; Region: HELICc; smart00490 456481009851 ATP-binding site [chemical binding]; other site 456481009852 Methyltransferase domain; Region: Methyltransf_26; pfam13659 456481009853 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 456481009854 HEAT repeats; Region: HEAT_2; pfam13646 456481009855 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 456481009856 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 456481009857 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 456481009858 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 456481009859 Walker A/P-loop; other site 456481009860 ATP binding site [chemical binding]; other site 456481009861 Q-loop/lid; other site 456481009862 ABC transporter signature motif; other site 456481009863 Walker B; other site 456481009864 D-loop; other site 456481009865 H-loop/switch region; other site 456481009866 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 456481009867 FtsX-like permease family; Region: FtsX; pfam02687 456481009868 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 456481009869 FtsX-like permease family; Region: FtsX; pfam02687 456481009870 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 456481009871 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 456481009872 HlyD family secretion protein; Region: HlyD_3; pfam13437 456481009873 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 456481009874 PAS domain S-box; Region: sensory_box; TIGR00229 456481009875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 456481009876 putative active site [active] 456481009877 heme pocket [chemical binding]; other site 456481009878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 456481009879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 456481009880 dimer interface [polypeptide binding]; other site 456481009881 phosphorylation site [posttranslational modification] 456481009882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 456481009883 ATP binding site [chemical binding]; other site 456481009884 Mg2+ binding site [ion binding]; other site 456481009885 G-X-G motif; other site 456481009886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 456481009887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 456481009888 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 456481009889 RibD C-terminal domain; Region: RibD_C; cl17279 456481009890 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 456481009891 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 456481009892 putative active site [active] 456481009893 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 456481009894 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 456481009895 serine/threonine protein kinase; Provisional; Region: PRK11768 456481009896 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 456481009897 Response regulator receiver domain; Region: Response_reg; pfam00072 456481009898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 456481009899 active site 456481009900 phosphorylation site [posttranslational modification] 456481009901 intermolecular recognition site; other site 456481009902 dimerization interface [polypeptide binding]; other site 456481009903 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 456481009904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 456481009905 metal binding site [ion binding]; metal-binding site 456481009906 active site 456481009907 I-site; other site 456481009908 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 456481009909 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 456481009910 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 456481009911 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 456481009912 Ligand binding site; other site 456481009913 DXD motif; other site 456481009914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 456481009915 Helix-turn-helix domain; Region: HTH_36; pfam13730