-- dump date   	20140619_131142
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
355276000001	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
355276000002	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
355276000003	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
355276000004	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
355276000005	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
355276000006	homodimer interface [polypeptide binding]; other site
355276000007	substrate-cofactor binding pocket; other site
355276000008	catalytic residue [active]
355276000009	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
355276000010	DNA polymerase III subunit delta'; Validated; Region: PRK08485
355276000011	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
355276000012	DnaA N-terminal domain; Region: DnaA_N; pfam11638
355276000013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276000014	Walker A motif; other site
355276000015	ATP binding site [chemical binding]; other site
355276000016	Walker B motif; other site
355276000017	arginine finger; other site
355276000018	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
355276000019	DnaA box-binding interface [nucleotide binding]; other site
355276000020	DNA polymerase III subunit beta; Provisional; Region: PRK14942
355276000021	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
355276000022	putative DNA binding surface [nucleotide binding]; other site
355276000023	dimer interface [polypeptide binding]; other site
355276000024	beta-clamp/clamp loader binding surface; other site
355276000025	beta-clamp/translesion DNA polymerase binding surface; other site
355276000026	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
355276000027	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
355276000028	Walker A/P-loop; other site
355276000029	ATP binding site [chemical binding]; other site
355276000030	Q-loop/lid; other site
355276000031	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276000032	ABC transporter signature motif; other site
355276000033	Walker B; other site
355276000034	D-loop; other site
355276000035	H-loop/switch region; other site
355276000036	Protein of unknown function (DUF721); Region: DUF721; pfam05258
355276000037	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
355276000038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276000039	Mg2+ binding site [ion binding]; other site
355276000040	G-X-G motif; other site
355276000041	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
355276000042	anchoring element; other site
355276000043	dimer interface [polypeptide binding]; other site
355276000044	ATP binding site [chemical binding]; other site
355276000045	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
355276000046	active site
355276000047	putative metal-binding site [ion binding]; other site
355276000048	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
355276000049	DNA gyrase subunit A; Validated; Region: PRK05560
355276000050	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
355276000051	CAP-like domain; other site
355276000052	active site
355276000053	primary dimer interface [polypeptide binding]; other site
355276000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
355276000055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
355276000056	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
355276000057	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
355276000058	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
355276000059	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
355276000060	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
355276000061	FMN binding site [chemical binding]; other site
355276000062	active site
355276000063	catalytic residues [active]
355276000064	substrate binding site [chemical binding]; other site
355276000065	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
355276000066	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
355276000067	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
355276000068	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
355276000069	DNA polymerase III, delta subunit; Region: holA; TIGR01128
355276000070	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
355276000071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000072	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000073	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000074	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276000075	cyclase homology domain; Region: CHD; cd07302
355276000076	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276000077	nucleotidyl binding site; other site
355276000078	metal binding site [ion binding]; metal-binding site
355276000079	dimer interface [polypeptide binding]; other site
355276000080	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
355276000081	FliG C-terminal domain; Region: FliG_C; pfam01706
355276000082	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
355276000083	ArsC family; Region: ArsC; pfam03960
355276000084	putative ArsC-like catalytic residues; other site
355276000085	putative TRX-like catalytic residues [active]
355276000086	HEAT repeats; Region: HEAT_2; pfam13646
355276000087	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
355276000088	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
355276000089	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
355276000090	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
355276000091	Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920
355276000092	putative active site [active]
355276000093	redox center [active]
355276000094	Thioredoxin; Region: Thioredoxin_4; pfam13462
355276000095	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
355276000096	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
355276000097	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
355276000098	catalytic residues [active]
355276000099	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK14004
355276000100	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
355276000101	putative active site [active]
355276000102	oxyanion strand; other site
355276000103	catalytic triad [active]
355276000104	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
355276000105	putative active site pocket [active]
355276000106	4-fold oligomerization interface [polypeptide binding]; other site
355276000107	metal binding residues [ion binding]; metal-binding site
355276000108	3-fold/trimer interface [polypeptide binding]; other site
355276000109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276000110	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276000111	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
355276000112	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
355276000113	nudix motif; other site
355276000114	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
355276000115	peptide chain release factor 1; Validated; Region: prfA; PRK00591
355276000116	PCRF domain; Region: PCRF; pfam03462
355276000117	RF-1 domain; Region: RF-1; pfam00472
355276000118	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
355276000119	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
355276000120	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276000121	catalytic residue [active]
355276000122	MASE1; Region: MASE1; pfam05231
355276000123	aminodeoxychorismate synthase; Provisional; Region: PRK07508
355276000124	chorismate binding enzyme; Region: Chorismate_bind; cl10555
355276000125	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
355276000126	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
355276000127	substrate-cofactor binding pocket; other site
355276000128	homodimer interface [polypeptide binding]; other site
355276000129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276000130	catalytic residue [active]
355276000131	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
355276000132	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
355276000133	acyl-activating enzyme (AAE) consensus motif; other site
355276000134	CoA binding site [chemical binding]; other site
355276000135	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
355276000136	AMP binding site [chemical binding]; other site
355276000137	active site
355276000138	CoA binding site [chemical binding]; other site
355276000139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000140	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000141	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000142	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
355276000143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276000144	S-adenosylmethionine binding site [chemical binding]; other site
355276000145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000146	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000147	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000148	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
355276000149	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
355276000150	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
355276000151	trimer interface [polypeptide binding]; other site
355276000152	active site
355276000153	UDP-GlcNAc binding site [chemical binding]; other site
355276000154	lipid binding site [chemical binding]; lipid-binding site
355276000155	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
355276000156	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
355276000157	FAD binding pocket [chemical binding]; other site
355276000158	conserved FAD binding motif [chemical binding]; other site
355276000159	phosphate binding motif [ion binding]; other site
355276000160	beta-alpha-beta structure motif; other site
355276000161	NAD binding pocket [chemical binding]; other site
355276000162	Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229
355276000163	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
355276000164	nucleoside/Zn binding site; other site
355276000165	dimer interface [polypeptide binding]; other site
355276000166	catalytic motif [active]
355276000167	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14956
355276000168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276000169	Walker A motif; other site
355276000170	ATP binding site [chemical binding]; other site
355276000171	Walker B motif; other site
355276000172	arginine finger; other site
355276000173	hypothetical protein; Provisional; Region: PRK14624
355276000174	recombination protein RecR; Reviewed; Region: recR; PRK00076
355276000175	RecR protein; Region: RecR; pfam02132
355276000176	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
355276000177	putative active site [active]
355276000178	putative metal-binding site [ion binding]; other site
355276000179	tetramer interface [polypeptide binding]; other site
355276000180	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
355276000181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
355276000182	substrate binding pocket [chemical binding]; other site
355276000183	membrane-bound complex binding site; other site
355276000184	hinge residues; other site
355276000185	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
355276000186	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
355276000187	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276000188	ligand binding site [chemical binding]; other site
355276000189	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000190	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000191	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000193	binding surface
355276000194	TPR repeat; Region: TPR_11; pfam13414
355276000195	TPR motif; other site
355276000196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000197	binding surface
355276000198	TPR motif; other site
355276000199	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
355276000200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000201	binding surface
355276000202	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276000203	TPR motif; other site
355276000204	ribonuclease R; Region: RNase_R; TIGR02063
355276000205	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276000206	RNB domain; Region: RNB; pfam00773
355276000207	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276000208	RNA binding site [nucleotide binding]; other site
355276000209	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
355276000210	Glycoprotease family; Region: Peptidase_M22; pfam00814
355276000211	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
355276000212	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
355276000213	dimerization interface [polypeptide binding]; other site
355276000214	domain crossover interface; other site
355276000215	redox-dependent activation switch; other site
355276000216	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
355276000217	active site
355276000218	dimerization interface [polypeptide binding]; other site
355276000219	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
355276000220	Cytochrome c; Region: Cytochrom_C; pfam00034
355276000221	Predicted membrane protein [Function unknown]; Region: COG3748
355276000222	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
355276000223	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
355276000224	active site
355276000225	Zn binding site [ion binding]; other site
355276000226	Protein of unknown function (DUF423); Region: DUF423; pfam04241
355276000227	TRL-like protein family; Region: TRL; pfam13146
355276000228	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
355276000229	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276000230	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276000231	FlgN protein; Region: FlgN; pfam05130
355276000232	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665
355276000233	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
355276000234	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
355276000235	flagellar hook-associated protein FlgL; Validated; Region: PRK06663
355276000236	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
355276000237	flagellar assembly protein FliW; Provisional; Region: PRK13285
355276000238	carbon storage regulator; Provisional; Region: PRK01712
355276000239	Short C-terminal domain; Region: SHOCT; pfam09851
355276000240	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
355276000241	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
355276000242	TrkA-N domain; Region: TrkA_N; pfam02254
355276000243	intracellular protease, PfpI family; Region: PfpI; TIGR01382
355276000244	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
355276000245	conserved cys residue [active]
355276000246	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
355276000247	catalytic residues [active]
355276000248	dimer interface [polypeptide binding]; other site
355276000249	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
355276000250	MarR family; Region: MarR; pfam01047
355276000251	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
355276000252	extended (e) SDRs; Region: SDR_e; cd08946
355276000253	NAD(P) binding site [chemical binding]; other site
355276000254	active site
355276000255	substrate binding site [chemical binding]; other site
355276000256	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
355276000257	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
355276000258	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
355276000259	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
355276000260	putative acyl-acceptor binding pocket; other site
355276000261	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
355276000262	ATP-grasp domain; Region: ATP-grasp; pfam02222
355276000263	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
355276000264	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276000265	Helix-turn-helix domain; Region: HTH_18; pfam12833
355276000266	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000267	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000268	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000269	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
355276000270	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
355276000271	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
355276000272	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
355276000273	hydrogenase 4 subunit F; Validated; Region: PRK06458
355276000274	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
355276000275	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
355276000276	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
355276000277	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
355276000278	Domain of unknown function (DUF897); Region: DUF897; pfam05982
355276000279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000280	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000281	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000282	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
355276000283	cobalamin binding residues [chemical binding]; other site
355276000284	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
355276000285	putative BtuC binding residues; other site
355276000286	dimer interface [polypeptide binding]; other site
355276000287	acetyl-CoA synthetase; Provisional; Region: PRK00174
355276000288	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
355276000289	active site
355276000290	CoA binding site [chemical binding]; other site
355276000291	acyl-activating enzyme (AAE) consensus motif; other site
355276000292	AMP binding site [chemical binding]; other site
355276000293	acetate binding site [chemical binding]; other site
355276000294	GTP cyclohydrolase I; Provisional; Region: PLN03044
355276000295	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
355276000296	homodecamer interface [polypeptide binding]; other site
355276000297	active site
355276000298	putative catalytic site residues [active]
355276000299	zinc binding site [ion binding]; other site
355276000300	GTP-CH-I/GFRP interaction surface; other site
355276000301	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
355276000302	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276000303	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
355276000304	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
355276000305	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
355276000306	TrkA-N domain; Region: TrkA_N; pfam02254
355276000307	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
355276000308	active site
355276000309	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
355276000310	catalytic core [active]
355276000311	Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409
355276000312	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
355276000313	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
355276000314	quinone interaction residues [chemical binding]; other site
355276000315	active site
355276000316	catalytic residues [active]
355276000317	FMN binding site [chemical binding]; other site
355276000318	substrate binding site [chemical binding]; other site
355276000319	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
355276000320	ABC-2 type transporter; Region: ABC2_membrane; cl17235
355276000321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000322	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000323	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000324	Fructosamine kinase; Region: Fructosamin_kin; cl17579
355276000325	Phosphotransferase enzyme family; Region: APH; pfam01636
355276000326	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
355276000327	active site
355276000328	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
355276000329	Helix-turn-helix domain; Region: HTH_18; pfam12833
355276000330	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
355276000331	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
355276000332	DNA binding site [nucleotide binding]
355276000333	active site
355276000334	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276000335	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276000336	dimer interface [polypeptide binding]; other site
355276000337	putative CheW interface [polypeptide binding]; other site
355276000338	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
355276000339	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
355276000340	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
355276000341	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
355276000342	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
355276000343	putative active site [active]
355276000344	putative metal binding site [ion binding]; other site
355276000345	Acyltransferase family; Region: Acyl_transf_3; pfam01757
355276000346	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276000347	dimerization interface [polypeptide binding]; other site
355276000348	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276000349	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276000350	dimer interface [polypeptide binding]; other site
355276000351	putative CheW interface [polypeptide binding]; other site
355276000352	ketol-acid reductoisomerase; Provisional; Region: PRK05479
355276000353	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
355276000354	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
355276000355	Caspase domain; Region: Peptidase_C14; pfam00656
355276000356	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
355276000357	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
355276000358	Walker A/P-loop; other site
355276000359	ATP binding site [chemical binding]; other site
355276000360	Q-loop/lid; other site
355276000361	ABC transporter signature motif; other site
355276000362	Walker B; other site
355276000363	D-loop; other site
355276000364	H-loop/switch region; other site
355276000365	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
355276000366	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
355276000367	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
355276000368	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
355276000369	Walker A/P-loop; other site
355276000370	ATP binding site [chemical binding]; other site
355276000371	Q-loop/lid; other site
355276000372	ABC transporter signature motif; other site
355276000373	Walker B; other site
355276000374	D-loop; other site
355276000375	H-loop/switch region; other site
355276000376	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
355276000377	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
355276000378	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
355276000379	Walker A/P-loop; other site
355276000380	ATP binding site [chemical binding]; other site
355276000381	Q-loop/lid; other site
355276000382	ABC transporter signature motif; other site
355276000383	Walker B; other site
355276000384	D-loop; other site
355276000385	H-loop/switch region; other site
355276000386	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
355276000387	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
355276000388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
355276000389	dimer interface [polypeptide binding]; other site
355276000390	conserved gate region; other site
355276000391	putative PBP binding loops; other site
355276000392	ABC-ATPase subunit interface; other site
355276000393	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
355276000394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
355276000395	dimer interface [polypeptide binding]; other site
355276000396	conserved gate region; other site
355276000397	putative PBP binding loops; other site
355276000398	ABC-ATPase subunit interface; other site
355276000399	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
355276000400	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
355276000401	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
355276000402	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
355276000403	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
355276000404	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
355276000405	active site
355276000406	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
355276000407	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
355276000408	active site
355276000409	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
355276000410	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
355276000411	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
355276000412	dimer interface [polypeptide binding]; other site
355276000413	motif 1; other site
355276000414	active site
355276000415	motif 2; other site
355276000416	motif 3; other site
355276000417	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
355276000418	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
355276000419	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
355276000420	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
355276000421	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
355276000422	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
355276000423	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
355276000424	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
355276000425	Walker A/P-loop; other site
355276000426	ATP binding site [chemical binding]; other site
355276000427	Q-loop/lid; other site
355276000428	ABC transporter signature motif; other site
355276000429	Walker B; other site
355276000430	D-loop; other site
355276000431	H-loop/switch region; other site
355276000432	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
355276000433	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
355276000434	argininosuccinate synthase; Provisional; Region: PRK13820
355276000435	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
355276000436	ANP binding site [chemical binding]; other site
355276000437	Substrate Binding Site II [chemical binding]; other site
355276000438	Substrate Binding Site I [chemical binding]; other site
355276000439	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
355276000440	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
355276000441	active site
355276000442	(T/H)XGH motif; other site
355276000443	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
355276000444	active site
355276000445	multimer interface [polypeptide binding]; other site
355276000446	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
355276000447	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
355276000448	active site
355276000449	Predicted acetyltransferase [General function prediction only]; Region: COG2388
355276000450	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
355276000451	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
355276000452	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
355276000453	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
355276000454	MarR family; Region: MarR; pfam01047
355276000455	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
355276000456	Uncharacterized conserved protein [Function unknown]; Region: COG0585
355276000457	active site
355276000458	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
355276000459	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
355276000460	active site
355276000461	catalytic tetrad [active]
355276000462	TPR repeat; Region: TPR_11; pfam13414
355276000463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000464	binding surface
355276000465	TPR motif; other site
355276000466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000467	binding surface
355276000468	TPR motif; other site
355276000469	TPR repeat; Region: TPR_11; pfam13414
355276000470	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
355276000471	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
355276000472	putative heme binding pocket [chemical binding]; other site
355276000473	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276000474	anti sigma factor interaction site; other site
355276000475	regulatory phosphorylation site [posttranslational modification]; other site
355276000476	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
355276000477	active site
355276000478	dimerization interface [polypeptide binding]; other site
355276000479	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
355276000480	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276000481	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276000482	ABC transporter; Region: ABC_tran_2; pfam12848
355276000483	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276000484	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
355276000485	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
355276000486	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
355276000487	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276000488	ligand binding site [chemical binding]; other site
355276000489	phosphoglyceromutase; Provisional; Region: PRK05434
355276000490	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
355276000491	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000492	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000493	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000494	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276000495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276000496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276000497	DNA binding residues [nucleotide binding]
355276000498	FecR protein; Region: FecR; pfam04773
355276000499	DoxX; Region: DoxX; pfam07681
355276000500	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
355276000501	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276000502	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276000503	ABC transporter; Region: ABC_tran_2; pfam12848
355276000504	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276000505	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
355276000506	active site residue [active]
355276000507	putative acyltransferase; Provisional; Region: PRK05790
355276000508	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
355276000509	dimer interface [polypeptide binding]; other site
355276000510	active site
355276000511	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276000512	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276000513	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276000514	active site
355276000515	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
355276000516	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
355276000517	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
355276000518	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
355276000519	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
355276000520	glutamine binding [chemical binding]; other site
355276000521	catalytic triad [active]
355276000522	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
355276000523	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
355276000524	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
355276000525	Walker A/P-loop; other site
355276000526	ATP binding site [chemical binding]; other site
355276000527	Q-loop/lid; other site
355276000528	ABC transporter signature motif; other site
355276000529	Walker B; other site
355276000530	D-loop; other site
355276000531	H-loop/switch region; other site
355276000532	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276000533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276000534	active site
355276000535	phosphorylation site [posttranslational modification]
355276000536	intermolecular recognition site; other site
355276000537	HEAT repeats; Region: HEAT_2; pfam13646
355276000538	HEAT repeats; Region: HEAT_2; pfam13646
355276000539	HEAT repeats; Region: HEAT_2; pfam13646
355276000540	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
355276000541	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
355276000542	HflX GTPase family; Region: HflX; cd01878
355276000543	G1 box; other site
355276000544	GTP/Mg2+ binding site [chemical binding]; other site
355276000545	Switch I region; other site
355276000546	G2 box; other site
355276000547	G3 box; other site
355276000548	Switch II region; other site
355276000549	G4 box; other site
355276000550	G5 box; other site
355276000551	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276000552	anti sigma factor interaction site; other site
355276000553	regulatory phosphorylation site [posttranslational modification]; other site
355276000554	homoserine dehydrogenase; Provisional; Region: PRK06349
355276000555	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
355276000556	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
355276000557	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
355276000558	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
355276000559	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
355276000560	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
355276000561	active site
355276000562	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
355276000563	Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Region: Pat_hypo_W_succinogenes_WS1459_like; cd07210
355276000564	active site
355276000565	nucleophile elbow; other site
355276000566	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
355276000567	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
355276000568	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276000569	ligand binding site [chemical binding]; other site
355276000570	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
355276000571	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
355276000572	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
355276000573	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
355276000574	Active Sites [active]
355276000575	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
355276000576	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
355276000577	Active Sites [active]
355276000578	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
355276000579	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
355276000580	CysD dimerization site [polypeptide binding]; other site
355276000581	G1 box; other site
355276000582	putative GEF interaction site [polypeptide binding]; other site
355276000583	GTP/Mg2+ binding site [chemical binding]; other site
355276000584	Switch I region; other site
355276000585	G2 box; other site
355276000586	G3 box; other site
355276000587	Switch II region; other site
355276000588	G4 box; other site
355276000589	G5 box; other site
355276000590	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
355276000591	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
355276000592	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
355276000593	active site
355276000594	SAM binding site [chemical binding]; other site
355276000595	homodimer interface [polypeptide binding]; other site
355276000596	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
355276000597	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
355276000598	sulfite reductase subunit beta; Provisional; Region: PRK13504
355276000599	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
355276000600	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
355276000601	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
355276000602	Strictosidine synthase; Region: Str_synth; pfam03088
355276000603	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276000604	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
355276000605	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276000606	CAAX protease self-immunity; Region: Abi; pfam02517
355276000607	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
355276000608	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
355276000609	Cl- selectivity filter; other site
355276000610	Cl- binding residues [ion binding]; other site
355276000611	pore gating glutamate residue; other site
355276000612	dimer interface [polypeptide binding]; other site
355276000613	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
355276000614	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
355276000615	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
355276000616	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
355276000617	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
355276000618	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
355276000619	von Willebrand factor type A domain; Region: VWA_2; pfam13519
355276000620	metal ion-dependent adhesion site (MIDAS); other site
355276000621	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
355276000622	catalytic core [active]
355276000623	cobalamin synthase; Reviewed; Region: cobS; PRK00235
355276000624	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
355276000625	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
355276000626	putative dimer interface [polypeptide binding]; other site
355276000627	active site pocket [active]
355276000628	putative cataytic base [active]
355276000629	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
355276000630	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
355276000631	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
355276000632	TopoisomeraseII; Region: TOP2c; smart00433
355276000633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276000634	ATP binding site [chemical binding]; other site
355276000635	Mg2+ binding site [ion binding]; other site
355276000636	G-X-G motif; other site
355276000637	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
355276000638	ATP binding site [chemical binding]; other site
355276000639	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
355276000640	active site
355276000641	putative metal-binding site [ion binding]; other site
355276000642	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
355276000643	CAP-like domain; other site
355276000644	DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521
355276000645	active site
355276000646	primary dimer interface [polypeptide binding]; other site
355276000647	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
355276000648	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
355276000649	HIGH motif; other site
355276000650	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
355276000651	active site
355276000652	KMSKS motif; other site
355276000653	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276000654	Protein of unknown function (DUF455); Region: DUF455; pfam04305
355276000655	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
355276000656	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
355276000657	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
355276000658	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276000659	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
355276000660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276000661	homodimer interface [polypeptide binding]; other site
355276000662	catalytic residue [active]
355276000663	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
355276000664	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
355276000665	PAS domain S-box; Region: sensory_box; TIGR00229
355276000666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276000667	putative active site [active]
355276000668	heme pocket [chemical binding]; other site
355276000669	PAS domain S-box; Region: sensory_box; TIGR00229
355276000670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276000671	putative active site [active]
355276000672	heme pocket [chemical binding]; other site
355276000673	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276000674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276000675	ATP binding site [chemical binding]; other site
355276000676	Mg2+ binding site [ion binding]; other site
355276000677	G-X-G motif; other site
355276000678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276000679	Response regulator receiver domain; Region: Response_reg; pfam00072
355276000680	active site
355276000681	phosphorylation site [posttranslational modification]
355276000682	intermolecular recognition site; other site
355276000683	dimerization interface [polypeptide binding]; other site
355276000684	isocitrate dehydrogenase; Validated; Region: PRK09222
355276000685	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
355276000686	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
355276000687	UbiA prenyltransferase family; Region: UbiA; pfam01040
355276000688	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
355276000689	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
355276000690	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
355276000691	Cu(I) binding site [ion binding]; other site
355276000692	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
355276000693	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
355276000694	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
355276000695	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
355276000696	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
355276000697	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
355276000698	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
355276000699	Subunit I/III interface [polypeptide binding]; other site
355276000700	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
355276000701	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
355276000702	putative active site [active]
355276000703	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
355276000704	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
355276000705	active site
355276000706	substrate-binding site [chemical binding]; other site
355276000707	metal-binding site [ion binding]
355276000708	ATP binding site [chemical binding]; other site
355276000709	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
355276000710	Neurokinin B; Region: Neurokinin_B; pfam03823
355276000711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
355276000712	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
355276000713	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276000714	P-loop; other site
355276000715	Magnesium ion binding site [ion binding]; other site
355276000716	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276000717	Magnesium ion binding site [ion binding]; other site
355276000718	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
355276000719	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
355276000720	GatB domain; Region: GatB_Yqey; smart00845
355276000721	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
355276000722	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
355276000723	active site
355276000724	PHP Thumb interface [polypeptide binding]; other site
355276000725	metal binding site [ion binding]; metal-binding site
355276000726	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
355276000727	generic binding surface I; other site
355276000728	generic binding surface II; other site
355276000729	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276000730	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276000731	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276000732	CHAT domain; Region: CHAT; pfam12770
355276000733	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
355276000734	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
355276000735	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
355276000736	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
355276000737	Walker A/P-loop; other site
355276000738	ATP binding site [chemical binding]; other site
355276000739	Q-loop/lid; other site
355276000740	ABC transporter signature motif; other site
355276000741	Walker B; other site
355276000742	D-loop; other site
355276000743	H-loop/switch region; other site
355276000744	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
355276000745	phosphagen binding site; other site
355276000746	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
355276000747	Clp amino terminal domain; Region: Clp_N; pfam02861
355276000748	Clp amino terminal domain; Region: Clp_N; pfam02861
355276000749	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276000750	Walker A motif; other site
355276000751	ATP binding site [chemical binding]; other site
355276000752	Walker B motif; other site
355276000753	arginine finger; other site
355276000754	UvrB/uvrC motif; Region: UVR; pfam02151
355276000755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276000756	Walker A motif; other site
355276000757	ATP binding site [chemical binding]; other site
355276000758	Walker B motif; other site
355276000759	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
355276000760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000761	binding surface
355276000762	TPR motif; other site
355276000763	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
355276000764	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
355276000765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276000766	FeS/SAM binding site; other site
355276000767	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
355276000768	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
355276000769	Methyltransferase domain; Region: Methyltransf_18; pfam12847
355276000770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
355276000771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000772	binding surface
355276000773	TPR motif; other site
355276000774	TPR repeat; Region: TPR_11; pfam13414
355276000775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000776	binding surface
355276000777	TPR motif; other site
355276000778	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276000779	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
355276000780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000781	TPR motif; other site
355276000782	binding surface
355276000783	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276000784	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
355276000785	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
355276000786	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
355276000787	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276000788	catalytic residue [active]
355276000789	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
355276000790	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
355276000791	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12729
355276000792	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
355276000793	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
355276000794	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
355276000795	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624
355276000796	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
355276000797	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276000798	anti sigma factor interaction site; other site
355276000799	regulatory phosphorylation site [posttranslational modification]; other site
355276000800	TPR repeat; Region: TPR_11; pfam13414
355276000801	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000802	binding surface
355276000803	TPR motif; other site
355276000804	TPR repeat; Region: TPR_11; pfam13414
355276000805	Fatty acid desaturase; Region: FA_desaturase; pfam00487
355276000806	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
355276000807	putative di-iron ligands [ion binding]; other site
355276000808	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
355276000809	Protein of unknown function (DUF454); Region: DUF454; pfam04304
355276000810	Dienelactone hydrolase family; Region: DLH; pfam01738
355276000811	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000812	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000813	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276000815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276000816	dimer interface [polypeptide binding]; other site
355276000817	phosphorylation site [posttranslational modification]
355276000818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276000819	ATP binding site [chemical binding]; other site
355276000820	Mg2+ binding site [ion binding]; other site
355276000821	G-X-G motif; other site
355276000822	Response regulator receiver domain; Region: Response_reg; pfam00072
355276000823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276000824	active site
355276000825	phosphorylation site [posttranslational modification]
355276000826	intermolecular recognition site; other site
355276000827	dimerization interface [polypeptide binding]; other site
355276000828	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
355276000829	glycine dehydrogenase; Provisional; Region: PRK05367
355276000830	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
355276000831	tetramer interface [polypeptide binding]; other site
355276000832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276000833	catalytic residue [active]
355276000834	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
355276000835	tetramer interface [polypeptide binding]; other site
355276000836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276000837	catalytic residue [active]
355276000838	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
355276000839	lipoyl attachment site [posttranslational modification]; other site
355276000840	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
355276000841	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
355276000842	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000843	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000844	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000845	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
355276000846	putative hydrophobic ligand binding site [chemical binding]; other site
355276000847	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
355276000848	putative DNA binding site [nucleotide binding]; other site
355276000849	putative Zn2+ binding site [ion binding]; other site
355276000850	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
355276000851	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
355276000852	active site
355276000853	catalytic site [active]
355276000854	metal binding site [ion binding]; metal-binding site
355276000855	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276000856	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276000857	TPR motif; other site
355276000858	TPR repeat; Region: TPR_11; pfam13414
355276000859	binding surface
355276000860	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
355276000861	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
355276000862	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
355276000863	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
355276000864	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
355276000865	Ligand Binding Site [chemical binding]; other site
355276000866	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
355276000867	active site
355276000868	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
355276000869	Galactose oxidase, central domain; Region: Kelch_3; cl02701
355276000870	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
355276000871	Kelch domain; Region: Kelch; smart00612
355276000872	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
355276000873	Galactose oxidase, central domain; Region: Kelch_3; cl02701
355276000874	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
355276000875	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
355276000876	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
355276000877	active site
355276000878	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
355276000879	Fe-S cluster binding site [ion binding]; other site
355276000880	active site
355276000881	acyl-CoA synthetase; Validated; Region: PRK07868
355276000882	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
355276000883	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
355276000884	methionine sulfoxide reductase A; Provisional; Region: PRK14054
355276000885	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
355276000886	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276000887	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
355276000888	FAD binding site [chemical binding]; other site
355276000889	substrate binding site [chemical binding]; other site
355276000890	catalytic residues [active]
355276000891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276000892	PAS domain; Region: PAS_9; pfam13426
355276000893	putative active site [active]
355276000894	heme pocket [chemical binding]; other site
355276000895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276000896	dimer interface [polypeptide binding]; other site
355276000897	phosphorylation site [posttranslational modification]
355276000898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276000899	ATP binding site [chemical binding]; other site
355276000900	Mg2+ binding site [ion binding]; other site
355276000901	G-X-G motif; other site
355276000902	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000903	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000904	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000905	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
355276000906	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
355276000907	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
355276000908	Integrase core domain; Region: rve; pfam00665
355276000909	Integrase core domain; Region: rve_3; pfam13683
355276000910	Integrase core domain; Region: rve; pfam00665
355276000911	Integrase core domain; Region: rve_3; pfam13683
355276000912	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
355276000913	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
355276000914	GDP-binding site [chemical binding]; other site
355276000915	ACT binding site; other site
355276000916	IMP binding site; other site
355276000917	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
355276000918	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
355276000919	motif 1; other site
355276000920	dimer interface [polypeptide binding]; other site
355276000921	active site
355276000922	motif 2; other site
355276000923	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
355276000924	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
355276000925	putative acyl-acceptor binding pocket; other site
355276000926	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
355276000927	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
355276000928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000929	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000930	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000931	Pirin-related protein [General function prediction only]; Region: COG1741
355276000932	Pirin; Region: Pirin; pfam02678
355276000933	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
355276000934	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
355276000935	hydrophobic ligand binding site; other site
355276000936	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276000937	GAF domain; Region: GAF; pfam01590
355276000938	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276000939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276000940	dimer interface [polypeptide binding]; other site
355276000941	phosphorylation site [posttranslational modification]
355276000942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276000943	ATP binding site [chemical binding]; other site
355276000944	Mg2+ binding site [ion binding]; other site
355276000945	G-X-G motif; other site
355276000946	Response regulator receiver domain; Region: Response_reg; pfam00072
355276000947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276000948	active site
355276000949	phosphorylation site [posttranslational modification]
355276000950	intermolecular recognition site; other site
355276000951	dimerization interface [polypeptide binding]; other site
355276000952	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
355276000953	dimer interface [polypeptide binding]; other site
355276000954	catalytic triad [active]
355276000955	peroxidatic and resolving cysteines [active]
355276000956	thiamine monophosphate kinase; Provisional; Region: PRK05731
355276000957	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
355276000958	ATP binding site [chemical binding]; other site
355276000959	dimerization interface [polypeptide binding]; other site
355276000960	YceI-like domain; Region: YceI; pfam04264
355276000961	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
355276000962	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
355276000963	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
355276000964	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
355276000965	Walker A/P-loop; other site
355276000966	ATP binding site [chemical binding]; other site
355276000967	Q-loop/lid; other site
355276000968	ABC transporter signature motif; other site
355276000969	Walker B; other site
355276000970	D-loop; other site
355276000971	H-loop/switch region; other site
355276000972	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
355276000973	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
355276000974	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
355276000975	Transglycosylase; Region: Transgly; pfam00912
355276000976	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
355276000977	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
355276000978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276000979	S-adenosylmethionine binding site [chemical binding]; other site
355276000980	AAA domain; Region: AAA_33; pfam13671
355276000981	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
355276000982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276000983	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276000984	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276000985	Predicted membrane protein [Function unknown]; Region: COG2259
355276000986	elongation factor G; Reviewed; Region: PRK13351
355276000987	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
355276000988	G1 box; other site
355276000989	GTP/Mg2+ binding site [chemical binding]; other site
355276000990	G2 box; other site
355276000991	Switch I region; other site
355276000992	G3 box; other site
355276000993	Switch II region; other site
355276000994	G4 box; other site
355276000995	G5 box; other site
355276000996	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514
355276000997	elongation factor Tu; Reviewed; Region: PRK00049
355276000998	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
355276000999	G1 box; other site
355276001000	GEF interaction site [polypeptide binding]; other site
355276001001	GTP/Mg2+ binding site [chemical binding]; other site
355276001002	Switch I region; other site
355276001003	G2 box; other site
355276001004	G3 box; other site
355276001005	Switch II region; other site
355276001006	G4 box; other site
355276001007	G5 box; other site
355276001008	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
355276001009	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
355276001010	Antibiotic Binding Site [chemical binding]; other site
355276001011	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
355276001012	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
355276001013	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
355276001014	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
355276001015	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
355276001016	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
355276001017	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
355276001018	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
355276001019	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
355276001020	putative translocon binding site; other site
355276001021	protein-rRNA interface [nucleotide binding]; other site
355276001022	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
355276001023	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
355276001024	G-X-X-G motif; other site
355276001025	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
355276001026	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
355276001027	23S rRNA interface [nucleotide binding]; other site
355276001028	5S rRNA interface [nucleotide binding]; other site
355276001029	putative antibiotic binding site [chemical binding]; other site
355276001030	L25 interface [polypeptide binding]; other site
355276001031	L27 interface [polypeptide binding]; other site
355276001032	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
355276001033	putative translocon interaction site; other site
355276001034	23S rRNA interface [nucleotide binding]; other site
355276001035	signal recognition particle (SRP54) interaction site; other site
355276001036	L23 interface [polypeptide binding]; other site
355276001037	trigger factor interaction site; other site
355276001038	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
355276001039	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
355276001040	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
355276001041	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
355276001042	RNA binding site [nucleotide binding]; other site
355276001043	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
355276001044	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
355276001045	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
355276001046	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
355276001047	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
355276001048	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
355276001049	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
355276001050	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
355276001051	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
355276001052	5S rRNA interface [nucleotide binding]; other site
355276001053	L27 interface [polypeptide binding]; other site
355276001054	23S rRNA interface [nucleotide binding]; other site
355276001055	L5 interface [polypeptide binding]; other site
355276001056	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
355276001057	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
355276001058	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
355276001059	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
355276001060	23S rRNA binding site [nucleotide binding]; other site
355276001061	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
355276001062	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
355276001063	SecY translocase; Region: SecY; pfam00344
355276001064	adenylate kinase; Provisional; Region: PRK14528
355276001065	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
355276001066	AMP-binding site [chemical binding]; other site
355276001067	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
355276001068	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
355276001069	rRNA binding site [nucleotide binding]; other site
355276001070	predicted 30S ribosome binding site; other site
355276001071	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
355276001072	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
355276001073	30S ribosomal protein S13; Region: bact_S13; TIGR03631
355276001074	30S ribosomal protein S11; Validated; Region: PRK05309
355276001075	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
355276001076	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
355276001077	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
355276001078	RNA binding surface [nucleotide binding]; other site
355276001079	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
355276001080	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
355276001081	alphaNTD - beta interaction site [polypeptide binding]; other site
355276001082	alphaNTD homodimer interface [polypeptide binding]; other site
355276001083	alphaNTD - beta' interaction site [polypeptide binding]; other site
355276001084	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
355276001085	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
355276001086	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
355276001087	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
355276001088	ligand binding site [chemical binding]; other site
355276001089	NAD binding site [chemical binding]; other site
355276001090	catalytic site [active]
355276001091	homodimer interface [polypeptide binding]; other site
355276001092	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
355276001093	RNase_H superfamily; Region: RNase_H_2; pfam13482
355276001094	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
355276001095	Response regulator receiver domain; Region: Response_reg; pfam00072
355276001096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276001097	active site
355276001098	phosphorylation site [posttranslational modification]
355276001099	intermolecular recognition site; other site
355276001100	dimerization interface [polypeptide binding]; other site
355276001101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001102	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001103	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001104	Predicted membrane protein [Function unknown]; Region: COG2259
355276001105	elongation factor G; Reviewed; Region: PRK13351
355276001106	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
355276001107	G1 box; other site
355276001108	GTP/Mg2+ binding site [chemical binding]; other site
355276001109	G2 box; other site
355276001110	Switch I region; other site
355276001111	G3 box; other site
355276001112	Switch II region; other site
355276001113	G4 box; other site
355276001114	G5 box; other site
355276001115	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514
355276001116	elongation factor Tu; Reviewed; Region: PRK00049
355276001117	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
355276001118	G1 box; other site
355276001119	GEF interaction site [polypeptide binding]; other site
355276001120	GTP/Mg2+ binding site [chemical binding]; other site
355276001121	Switch I region; other site
355276001122	G2 box; other site
355276001123	G3 box; other site
355276001124	Switch II region; other site
355276001125	G4 box; other site
355276001126	G5 box; other site
355276001127	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
355276001128	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
355276001129	Antibiotic Binding Site [chemical binding]; other site
355276001130	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
355276001131	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
355276001132	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
355276001133	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
355276001134	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
355276001135	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
355276001136	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
355276001137	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
355276001138	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
355276001139	putative translocon binding site; other site
355276001140	protein-rRNA interface [nucleotide binding]; other site
355276001141	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
355276001142	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
355276001143	G-X-X-G motif; other site
355276001144	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
355276001145	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
355276001146	23S rRNA interface [nucleotide binding]; other site
355276001147	5S rRNA interface [nucleotide binding]; other site
355276001148	putative antibiotic binding site [chemical binding]; other site
355276001149	L25 interface [polypeptide binding]; other site
355276001150	L27 interface [polypeptide binding]; other site
355276001151	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
355276001152	putative translocon interaction site; other site
355276001153	23S rRNA interface [nucleotide binding]; other site
355276001154	signal recognition particle (SRP54) interaction site; other site
355276001155	L23 interface [polypeptide binding]; other site
355276001156	trigger factor interaction site; other site
355276001157	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
355276001158	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
355276001159	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
355276001160	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
355276001161	RNA binding site [nucleotide binding]; other site
355276001162	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
355276001163	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
355276001164	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
355276001165	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
355276001166	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
355276001167	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
355276001168	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
355276001169	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
355276001170	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
355276001171	5S rRNA interface [nucleotide binding]; other site
355276001172	L27 interface [polypeptide binding]; other site
355276001173	23S rRNA interface [nucleotide binding]; other site
355276001174	L5 interface [polypeptide binding]; other site
355276001175	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
355276001176	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
355276001177	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
355276001178	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
355276001179	23S rRNA binding site [nucleotide binding]; other site
355276001180	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
355276001181	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
355276001182	SecY translocase; Region: SecY; pfam00344
355276001183	adenylate kinase; Provisional; Region: PRK14528
355276001184	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
355276001185	AMP-binding site [chemical binding]; other site
355276001186	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
355276001187	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
355276001188	rRNA binding site [nucleotide binding]; other site
355276001189	predicted 30S ribosome binding site; other site
355276001190	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
355276001191	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
355276001192	30S ribosomal protein S13; Region: bact_S13; TIGR03631
355276001193	30S ribosomal protein S11; Validated; Region: PRK05309
355276001194	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
355276001195	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
355276001196	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
355276001197	RNA binding surface [nucleotide binding]; other site
355276001198	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
355276001199	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
355276001200	alphaNTD - beta interaction site [polypeptide binding]; other site
355276001201	alphaNTD homodimer interface [polypeptide binding]; other site
355276001202	alphaNTD - beta' interaction site [polypeptide binding]; other site
355276001203	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
355276001204	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
355276001205	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
355276001206	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
355276001207	ligand binding site [chemical binding]; other site
355276001208	NAD binding site [chemical binding]; other site
355276001209	catalytic site [active]
355276001210	homodimer interface [polypeptide binding]; other site
355276001211	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
355276001212	RNase_H superfamily; Region: RNase_H_2; pfam13482
355276001213	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
355276001214	Response regulator receiver domain; Region: Response_reg; pfam00072
355276001215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276001216	active site
355276001217	phosphorylation site [posttranslational modification]
355276001218	intermolecular recognition site; other site
355276001219	dimerization interface [polypeptide binding]; other site
355276001220	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001221	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001222	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001224	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001225	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001226	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
355276001227	putative hydrophobic ligand binding site [chemical binding]; other site
355276001228	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
355276001229	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
355276001230	substrate binding pocket [chemical binding]; other site
355276001231	chain length determination region; other site
355276001232	substrate-Mg2+ binding site; other site
355276001233	catalytic residues [active]
355276001234	aspartate-rich region 1; other site
355276001235	active site lid residues [active]
355276001236	aspartate-rich region 2; other site
355276001237	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
355276001238	transketolase; Reviewed; Region: PRK05899
355276001239	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
355276001240	TPP-binding site [chemical binding]; other site
355276001241	dimer interface [polypeptide binding]; other site
355276001242	Protein of unknown function (DUF420); Region: DUF420; cl00989
355276001243	Transglycosylase; Region: Transgly; pfam00912
355276001244	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
355276001245	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
355276001246	Protein of unknown function, DUF399; Region: DUF399; pfam04187
355276001247	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
355276001248	catalytic residues [active]
355276001249	dimer interface [polypeptide binding]; other site
355276001250	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001251	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001252	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
355276001254	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
355276001255	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
355276001256	putative NAD(P) binding site [chemical binding]; other site
355276001257	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
355276001258	HSP70 interaction site [polypeptide binding]; other site
355276001259	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
355276001260	Carbon starvation protein CstA; Region: CstA; pfam02554
355276001261	Carbon starvation protein CstA; Region: CstA; pfam02554
355276001262	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
355276001263	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
355276001264	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
355276001265	nudix motif; other site
355276001266	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
355276001267	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276001268	ligand binding site [chemical binding]; other site
355276001269	PilZ domain; Region: PilZ; pfam07238
355276001270	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
355276001271	spermidine synthase; Provisional; Region: PRK03612
355276001272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
355276001273	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001274	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001275	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001276	EVE domain; Region: EVE; cl00728
355276001277	FtsH Extracellular; Region: FtsH_ext; pfam06480
355276001278	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
355276001279	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276001280	Walker A motif; other site
355276001281	ATP binding site [chemical binding]; other site
355276001282	Walker B motif; other site
355276001283	arginine finger; other site
355276001284	Peptidase family M41; Region: Peptidase_M41; pfam01434
355276001285	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
355276001286	putative active site [active]
355276001287	catalytic residue [active]
355276001288	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
355276001289	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
355276001290	5S rRNA interface [nucleotide binding]; other site
355276001291	CTC domain interface [polypeptide binding]; other site
355276001292	L16 interface [polypeptide binding]; other site
355276001293	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
355276001294	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
355276001295	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
355276001296	active site
355276001297	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
355276001298	Substrate binding site; other site
355276001299	Mg++ binding site; other site
355276001300	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14613
355276001301	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
355276001302	Predicted transcriptional regulator [Transcription]; Region: COG2378
355276001303	WYL domain; Region: WYL; pfam13280
355276001304	Predicted membrane protein [Function unknown]; Region: COG1511
355276001305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001306	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001307	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001308	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
355276001309	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
355276001310	active site
355276001311	metal binding site [ion binding]; metal-binding site
355276001312	helicase 45; Provisional; Region: PTZ00424
355276001313	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
355276001314	ATP binding site [chemical binding]; other site
355276001315	Mg++ binding site [ion binding]; other site
355276001316	motif III; other site
355276001317	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276001318	nucleotide binding region [chemical binding]; other site
355276001319	ATP-binding site [chemical binding]; other site
355276001320	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276001321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276001322	S-adenosylmethionine binding site [chemical binding]; other site
355276001323	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
355276001324	homotrimer interaction site [polypeptide binding]; other site
355276001325	putative active site [active]
355276001326	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276001327	WYL domain; Region: WYL; pfam13280
355276001328	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276001329	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
355276001330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001331	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001332	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001333	DNA polymerase I; Provisional; Region: PRK05755
355276001334	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
355276001335	active site
355276001336	metal binding site 1 [ion binding]; metal-binding site
355276001337	putative 5' ssDNA interaction site; other site
355276001338	metal binding site 3; metal-binding site
355276001339	metal binding site 2 [ion binding]; metal-binding site
355276001340	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
355276001341	putative DNA binding site [nucleotide binding]; other site
355276001342	putative metal binding site [ion binding]; other site
355276001343	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
355276001344	active site
355276001345	catalytic site [active]
355276001346	substrate binding site [chemical binding]; other site
355276001347	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
355276001348	active site
355276001349	DNA binding site [nucleotide binding]
355276001350	catalytic site [active]
355276001351	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276001352	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
355276001353	putative ADP-binding pocket [chemical binding]; other site
355276001354	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
355276001355	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
355276001356	putative active site [active]
355276001357	putative dimer interface [polypeptide binding]; other site
355276001358	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
355276001359	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
355276001360	NAD(P) binding site [chemical binding]; other site
355276001361	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
355276001362	hypothetical protein; Provisional; Region: PRK10318
355276001363	Predicted membrane protein [Function unknown]; Region: COG4270
355276001364	flagellar motor protein MotS; Reviewed; Region: PRK06742
355276001365	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276001366	ligand binding site [chemical binding]; other site
355276001367	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276001368	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276001369	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
355276001370	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
355276001371	Catalytic site [active]
355276001372	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
355276001373	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
355276001374	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
355276001375	Short C-terminal domain; Region: SHOCT; pfam09851
355276001376	threonine synthase; Validated; Region: PRK06260
355276001377	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
355276001378	homodimer interface [polypeptide binding]; other site
355276001379	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276001380	catalytic residue [active]
355276001381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001382	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001383	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001385	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001386	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001387	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
355276001388	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
355276001389	HIGH motif; other site
355276001390	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
355276001391	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
355276001392	active site
355276001393	KMSKS motif; other site
355276001394	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
355276001395	tRNA binding surface [nucleotide binding]; other site
355276001396	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
355276001397	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
355276001398	Walker A/P-loop; other site
355276001399	ATP binding site [chemical binding]; other site
355276001400	Q-loop/lid; other site
355276001401	ABC transporter signature motif; other site
355276001402	Walker B; other site
355276001403	D-loop; other site
355276001404	H-loop/switch region; other site
355276001405	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
355276001406	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
355276001407	FtsX-like permease family; Region: FtsX; pfam02687
355276001408	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
355276001409	Citrate synthase; Region: Citrate_synt; pfam00285
355276001410	oxalacetate binding site [chemical binding]; other site
355276001411	citrylCoA binding site [chemical binding]; other site
355276001412	coenzyme A binding site [chemical binding]; other site
355276001413	catalytic triad [active]
355276001414	HEPN domain; Region: HEPN; pfam05168
355276001415	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
355276001416	active site
355276001417	NTP binding site [chemical binding]; other site
355276001418	metal binding triad [ion binding]; metal-binding site
355276001419	antibiotic binding site [chemical binding]; other site
355276001420	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
355276001421	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
355276001422	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
355276001423	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
355276001424	Beta-propeller repeat; Region: SBBP; pfam06739
355276001425	Beta-propeller repeat; Region: SBBP; pfam06739
355276001426	Beta-propeller repeat; Region: SBBP; pfam06739
355276001427	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
355276001428	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
355276001429	Predicted transcriptional regulators [Transcription]; Region: COG1695
355276001430	Transcriptional regulator PadR-like family; Region: PadR; cl17335
355276001431	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
355276001432	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276001433	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276001434	active site
355276001435	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
355276001436	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
355276001437	active site
355276001438	HIGH motif; other site
355276001439	KMSKS motif; other site
355276001440	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
355276001441	tRNA binding surface [nucleotide binding]; other site
355276001442	anticodon binding site; other site
355276001443	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
355276001444	putative tRNA-binding site [nucleotide binding]; other site
355276001445	dimer interface [polypeptide binding]; other site
355276001446	tellurium resistance terB-like protein; Region: terB_like; cl11965
355276001447	metal binding site [ion binding]; metal-binding site
355276001448	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
355276001449	HEAT repeats; Region: HEAT_2; pfam13646
355276001450	HEAT repeats; Region: HEAT_2; pfam13646
355276001451	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
355276001452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001453	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001454	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001455	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
355276001456	Protein export membrane protein; Region: SecD_SecF; cl14618
355276001457	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
355276001458	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
355276001459	tandem repeat interface [polypeptide binding]; other site
355276001460	oligomer interface [polypeptide binding]; other site
355276001461	active site residues [active]
355276001462	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
355276001463	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
355276001464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001465	binding surface
355276001466	TPR motif; other site
355276001467	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
355276001468	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
355276001469	putative NAD(P) binding site [chemical binding]; other site
355276001470	putative active site [active]
355276001471	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
355276001472	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
355276001473	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
355276001474	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
355276001475	active site
355276001476	(T/H)XGH motif; other site
355276001477	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
355276001478	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
355276001479	putative catalytic cysteine [active]
355276001480	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
355276001481	nucleotide binding site [chemical binding]; other site
355276001482	homotetrameric interface [polypeptide binding]; other site
355276001483	putative phosphate binding site [ion binding]; other site
355276001484	putative allosteric binding site; other site
355276001485	GTPase CgtA; Reviewed; Region: obgE; PRK12299
355276001486	GTP1/OBG; Region: GTP1_OBG; pfam01018
355276001487	Obg GTPase; Region: Obg; cd01898
355276001488	G1 box; other site
355276001489	GTP/Mg2+ binding site [chemical binding]; other site
355276001490	Switch I region; other site
355276001491	G2 box; other site
355276001492	G3 box; other site
355276001493	Switch II region; other site
355276001494	G4 box; other site
355276001495	G5 box; other site
355276001496	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
355276001497	hypothetical protein; Provisional; Region: PRK14553
355276001498	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; pfam00829
355276001499	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
355276001500	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
355276001501	putative NAD(P) binding site [chemical binding]; other site
355276001502	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
355276001503	putative single-stranded DNA-binding protein; Region: PHA01740
355276001504	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
355276001505	amidase catalytic site [active]
355276001506	Zn binding residues [ion binding]; other site
355276001507	substrate binding site [chemical binding]; other site
355276001508	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
355276001509	amidase catalytic site [active]
355276001510	Zn binding residues [ion binding]; other site
355276001511	substrate binding site [chemical binding]; other site
355276001512	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
355276001513	homopentamer interface [polypeptide binding]; other site
355276001514	active site
355276001515	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
355276001516	putative RNA binding site [nucleotide binding]; other site
355276001517	TPR repeat; Region: TPR_11; pfam13414
355276001518	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001519	TPR motif; other site
355276001520	binding surface
355276001521	TPR repeat; Region: TPR_11; pfam13414
355276001522	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001523	binding surface
355276001524	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276001525	TPR motif; other site
355276001526	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276001527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001528	binding surface
355276001529	TPR repeat; Region: TPR_11; pfam13414
355276001530	TPR motif; other site
355276001531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001532	binding surface
355276001533	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
355276001534	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
355276001535	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276001536	substrate binding site [chemical binding]; other site
355276001537	oxyanion hole (OAH) forming residues; other site
355276001538	trimer interface [polypeptide binding]; other site
355276001539	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
355276001540	structural tetrad; other site
355276001541	Uncharacterized conserved protein [Function unknown]; Region: COG3391
355276001542	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
355276001543	Acyltransferase family; Region: Acyl_transf_3; pfam01757
355276001544	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276001545	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276001546	ligand binding site [chemical binding]; other site
355276001547	flexible hinge region; other site
355276001548	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276001549	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276001550	active site
355276001551	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
355276001552	putative active site [active]
355276001553	putative substrate binding site [chemical binding]; other site
355276001554	ATP binding site [chemical binding]; other site
355276001555	Phosphotransferase enzyme family; Region: APH; pfam01636
355276001556	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
355276001557	catalytic core [active]
355276001558	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
355276001559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276001560	dimer interface [polypeptide binding]; other site
355276001561	phosphorylation site [posttranslational modification]
355276001562	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276001563	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276001564	ATP binding site [chemical binding]; other site
355276001565	Mg2+ binding site [ion binding]; other site
355276001566	G-X-G motif; other site
355276001567	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
355276001568	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
355276001569	C-terminal domain interface [polypeptide binding]; other site
355276001570	GSH binding site (G-site) [chemical binding]; other site
355276001571	dimer interface [polypeptide binding]; other site
355276001572	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
355276001573	N-terminal domain interface [polypeptide binding]; other site
355276001574	putative dimer interface [polypeptide binding]; other site
355276001575	active site
355276001576	Outer membrane efflux protein; Region: OEP; pfam02321
355276001577	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
355276001578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
355276001579	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
355276001580	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
355276001581	Protein of unknown function (DUF962); Region: DUF962; pfam06127
355276001582	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
355276001583	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
355276001584	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
355276001585	CT1975-like protein; Region: Cas_CT1975; pfam09344
355276001586	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
355276001587	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
355276001588	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
355276001589	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
355276001590	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
355276001591	Domain of unknown function (DUF389); Region: DUF389; pfam04087
355276001592	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
355276001593	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
355276001594	Walker A/P-loop; other site
355276001595	ATP binding site [chemical binding]; other site
355276001596	Q-loop/lid; other site
355276001597	ABC transporter signature motif; other site
355276001598	Walker B; other site
355276001599	D-loop; other site
355276001600	H-loop/switch region; other site
355276001601	FeS assembly protein SufD; Region: sufD; TIGR01981
355276001602	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
355276001603	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
355276001604	[2Fe-2S] cluster binding site [ion binding]; other site
355276001605	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
355276001606	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
355276001607	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276001608	catalytic residue [active]
355276001609	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
355276001610	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
355276001611	trimerization site [polypeptide binding]; other site
355276001612	active site
355276001613	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
355276001614	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
355276001615	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
355276001616	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
355276001617	active site residue [active]
355276001618	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
355276001619	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276001620	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276001621	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
355276001622	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
355276001623	active site
355276001624	HIGH motif; other site
355276001625	dimer interface [polypeptide binding]; other site
355276001626	KMSKS motif; other site
355276001627	Protein of unknown function (DUF1168); Region: DUF1168; pfam06658
355276001628	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
355276001629	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
355276001630	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
355276001631	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
355276001632	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
355276001633	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
355276001634	Ligand binding site [chemical binding]; other site
355276001635	Electron transfer flavoprotein domain; Region: ETF; pfam01012
355276001636	isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461
355276001637	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276001638	active site
355276001639	Helix-turn-helix domain; Region: HTH_18; pfam12833
355276001640	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
355276001641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276001642	non-specific DNA binding site [nucleotide binding]; other site
355276001643	salt bridge; other site
355276001644	sequence-specific DNA binding site [nucleotide binding]; other site
355276001645	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
355276001646	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276001647	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276001648	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276001649	active site
355276001650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001651	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001652	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001653	Predicted permeases [General function prediction only]; Region: COG0795
355276001654	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
355276001655	HEAT repeats; Region: HEAT_2; pfam13646
355276001656	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
355276001657	substrate binding site [chemical binding]; other site
355276001658	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557
355276001659	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
355276001660	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
355276001661	substrate binding pocket [chemical binding]; other site
355276001662	chain length determination region; other site
355276001663	substrate-Mg2+ binding site; other site
355276001664	catalytic residues [active]
355276001665	aspartate-rich region 1; other site
355276001666	active site lid residues [active]
355276001667	aspartate-rich region 2; other site
355276001668	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
355276001669	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
355276001670	RNA binding surface [nucleotide binding]; other site
355276001671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276001672	S-adenosylmethionine binding site [chemical binding]; other site
355276001673	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
355276001674	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
355276001675	23S rRNA interface [nucleotide binding]; other site
355276001676	L3 interface [polypeptide binding]; other site
355276001677	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
355276001678	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
355276001679	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
355276001680	motif 1; other site
355276001681	active site
355276001682	motif 2; other site
355276001683	motif 3; other site
355276001684	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
355276001685	DHHA1 domain; Region: DHHA1; pfam02272
355276001686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
355276001687	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
355276001688	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
355276001689	putative active site [active]
355276001690	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
355276001691	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
355276001692	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
355276001693	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
355276001694	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
355276001695	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
355276001696	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
355276001697	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
355276001698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
355276001699	Domain of unknown function (DUF955); Region: DUF955; pfam06114
355276001700	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
355276001701	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
355276001702	Cytochrome c; Region: Cytochrom_C; pfam00034
355276001703	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
355276001704	HAMP domain; Region: HAMP; pfam00672
355276001705	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276001706	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276001707	dimer interface [polypeptide binding]; other site
355276001708	putative CheW interface [polypeptide binding]; other site
355276001709	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
355276001710	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
355276001711	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
355276001712	putative homodimer interface [polypeptide binding]; other site
355276001713	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
355276001714	heterodimer interface [polypeptide binding]; other site
355276001715	homodimer interface [polypeptide binding]; other site
355276001716	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
355276001717	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
355276001718	23S rRNA interface [nucleotide binding]; other site
355276001719	L7/L12 interface [polypeptide binding]; other site
355276001720	putative thiostrepton binding site; other site
355276001721	L25 interface [polypeptide binding]; other site
355276001722	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
355276001723	mRNA/rRNA interface [nucleotide binding]; other site
355276001724	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
355276001725	23S rRNA interface [nucleotide binding]; other site
355276001726	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
355276001727	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
355276001728	core dimer interface [polypeptide binding]; other site
355276001729	peripheral dimer interface [polypeptide binding]; other site
355276001730	L10 interface [polypeptide binding]; other site
355276001731	L11 interface [polypeptide binding]; other site
355276001732	putative EF-Tu interaction site [polypeptide binding]; other site
355276001733	putative EF-G interaction site [polypeptide binding]; other site
355276001734	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
355276001735	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
355276001736	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
355276001737	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
355276001738	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
355276001739	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
355276001740	RPB10 interaction site [polypeptide binding]; other site
355276001741	RPB1 interaction site [polypeptide binding]; other site
355276001742	RPB11 interaction site [polypeptide binding]; other site
355276001743	RPB3 interaction site [polypeptide binding]; other site
355276001744	RPB12 interaction site [polypeptide binding]; other site
355276001745	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
355276001746	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
355276001747	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
355276001748	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
355276001749	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
355276001750	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
355276001751	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
355276001752	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
355276001753	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
355276001754	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
355276001755	DNA binding site [nucleotide binding]
355276001756	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
355276001757	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
355276001758	S17 interaction site [polypeptide binding]; other site
355276001759	S8 interaction site; other site
355276001760	16S rRNA interaction site [nucleotide binding]; other site
355276001761	streptomycin interaction site [chemical binding]; other site
355276001762	23S rRNA interaction site [nucleotide binding]; other site
355276001763	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
355276001764	30S ribosomal protein S7; Validated; Region: PRK05302
355276001765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001766	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001767	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001768	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
355276001769	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
355276001770	putative NAD(P) binding site [chemical binding]; other site
355276001771	catalytic Zn binding site [ion binding]; other site
355276001772	structural Zn binding site [ion binding]; other site
355276001773	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
355276001774	CoenzymeA binding site [chemical binding]; other site
355276001775	subunit interaction site [polypeptide binding]; other site
355276001776	PHB binding site; other site
355276001777	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
355276001778	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
355276001779	Pectinacetylesterase; Region: PAE; pfam03283
355276001780	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
355276001781	excinuclease ABC subunit B; Provisional; Region: PRK05298
355276001782	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276001783	ATP binding site [chemical binding]; other site
355276001784	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276001785	nucleotide binding region [chemical binding]; other site
355276001786	ATP-binding site [chemical binding]; other site
355276001787	Ultra-violet resistance protein B; Region: UvrB; pfam12344
355276001788	UvrB/uvrC motif; Region: UVR; pfam02151
355276001789	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276001790	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
355276001791	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
355276001792	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
355276001793	RNA binding site [nucleotide binding]; other site
355276001794	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
355276001795	RNA binding site [nucleotide binding]; other site
355276001796	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
355276001797	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
355276001798	nudix motif; other site
355276001799	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276001800	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
355276001801	putative metal binding site; other site
355276001802	Imelysin; Region: Peptidase_M75; pfam09375
355276001803	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
355276001804	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
355276001805	Imelysin; Region: Peptidase_M75; pfam09375
355276001806	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
355276001807	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
355276001808	N-terminal plug; other site
355276001809	ligand-binding site [chemical binding]; other site
355276001810	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
355276001811	Predicted amidohydrolase [General function prediction only]; Region: COG0388
355276001812	putative active site [active]
355276001813	catalytic triad [active]
355276001814	putative dimer interface [polypeptide binding]; other site
355276001815	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
355276001816	FAD binding domain; Region: FAD_binding_4; pfam01565
355276001817	polyphosphate kinase; Provisional; Region: PRK05443
355276001818	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
355276001819	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
355276001820	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
355276001821	putative domain interface [polypeptide binding]; other site
355276001822	putative active site [active]
355276001823	catalytic site [active]
355276001824	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
355276001825	putative domain interface [polypeptide binding]; other site
355276001826	putative active site [active]
355276001827	catalytic site [active]
355276001828	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
355276001829	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
355276001830	DXD motif; other site
355276001831	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
355276001832	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
355276001833	active site
355276001834	phosphorylation site [posttranslational modification]
355276001835	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
355276001836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
355276001837	dimer interface [polypeptide binding]; other site
355276001838	conserved gate region; other site
355276001839	putative PBP binding loops; other site
355276001840	ABC-ATPase subunit interface; other site
355276001841	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
355276001842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
355276001843	PEGA domain; Region: PEGA; pfam08308
355276001844	PEGA domain; Region: PEGA; pfam08308
355276001845	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
355276001846	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
355276001847	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
355276001848	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
355276001849	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
355276001850	shikimate binding site; other site
355276001851	NAD(P) binding site [chemical binding]; other site
355276001852	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
355276001853	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276001854	NAD(P) binding site [chemical binding]; other site
355276001855	active site
355276001856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276001857	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276001858	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276001859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276001860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276001861	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
355276001862	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
355276001863	active site
355276001864	catalytic residues [active]
355276001865	metal binding site [ion binding]; metal-binding site
355276001866	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
355276001867	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
355276001868	catalytic residues [active]
355276001869	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276001870	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
355276001871	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276001872	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
355276001873	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276001874	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276001875	MORN repeat; Region: MORN; cl14787
355276001876	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
355276001877	Outer membrane efflux protein; Region: OEP; pfam02321
355276001878	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
355276001879	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
355276001880	catalytic residues [active]
355276001881	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
355276001882	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
355276001883	Zn binding site [ion binding]; other site
355276001884	enterobactin exporter EntS; Provisional; Region: PRK10489
355276001885	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
355276001886	dimer interface [polypeptide binding]; other site
355276001887	ADP-ribose binding site [chemical binding]; other site
355276001888	active site
355276001889	nudix motif; other site
355276001890	metal binding site [ion binding]; metal-binding site
355276001891	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276001892	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
355276001893	Part of AAA domain; Region: AAA_19; pfam13245
355276001894	Family description; Region: UvrD_C_2; pfam13538
355276001895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001896	binding surface
355276001897	TPR motif; other site
355276001898	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
355276001899	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
355276001900	Ligand binding site; other site
355276001901	Putative Catalytic site; other site
355276001902	DXD motif; other site
355276001903	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276001904	anti sigma factor interaction site; other site
355276001905	regulatory phosphorylation site [posttranslational modification]; other site
355276001906	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
355276001907	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276001908	TPR repeat; Region: TPR_11; pfam13414
355276001909	TPR motif; other site
355276001910	binding surface
355276001911	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
355276001912	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
355276001913	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
355276001914	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
355276001915	protein binding site [polypeptide binding]; other site
355276001916	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
355276001917	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276001918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276001919	homodimer interface [polypeptide binding]; other site
355276001920	catalytic residue [active]
355276001921	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
355276001922	FecR protein; Region: FecR; pfam04773
355276001923	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
355276001924	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
355276001925	dimerization interface [polypeptide binding]; other site
355276001926	putative ATP binding site [chemical binding]; other site
355276001927	PAS domain S-box; Region: sensory_box; TIGR00229
355276001928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276001929	putative active site [active]
355276001930	heme pocket [chemical binding]; other site
355276001931	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
355276001932	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
355276001933	metal binding site [ion binding]; metal-binding site
355276001934	active site
355276001935	I-site; other site
355276001936	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
355276001937	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
355276001938	domain interfaces; other site
355276001939	active site
355276001940	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
355276001941	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
355276001942	putative active site [active]
355276001943	Zn binding site [ion binding]; other site
355276001944	Melibiase; Region: Melibiase; pfam02065
355276001945	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
355276001946	catalytic site [active]
355276001947	putative active site [active]
355276001948	putative substrate binding site [chemical binding]; other site
355276001949	DNA repair protein RadA; Provisional; Region: PRK11823
355276001950	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
355276001951	Walker A motif; other site
355276001952	ATP binding site [chemical binding]; other site
355276001953	Walker B motif; other site
355276001954	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
355276001955	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
355276001956	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
355276001957	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
355276001958	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
355276001959	Bacterial SH3 domain; Region: SH3_3; pfam08239
355276001960	Outer membrane efflux protein; Region: OEP; pfam02321
355276001961	Outer membrane efflux protein; Region: OEP; pfam02321
355276001962	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
355276001963	CoA binding domain; Region: CoA_binding; smart00881
355276001964	CoA-ligase; Region: Ligase_CoA; pfam00549
355276001965	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
355276001966	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
355276001967	CoA-ligase; Region: Ligase_CoA; pfam00549
355276001968	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
355276001969	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
355276001970	dimerization interface [polypeptide binding]; other site
355276001971	ATP binding site [chemical binding]; other site
355276001972	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
355276001973	dimerization interface [polypeptide binding]; other site
355276001974	ATP binding site [chemical binding]; other site
355276001975	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276001976	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
355276001977	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
355276001978	active site
355276001979	HIGH motif; other site
355276001980	nucleotide binding site [chemical binding]; other site
355276001981	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
355276001982	active site
355276001983	KMSKS motif; other site
355276001984	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
355276001985	tRNA binding surface [nucleotide binding]; other site
355276001986	anticodon binding site; other site
355276001987	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
355276001988	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276001989	anti sigma factor interaction site; other site
355276001990	regulatory phosphorylation site [posttranslational modification]; other site
355276001991	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
355276001992	Predicted amidohydrolase [General function prediction only]; Region: COG0388
355276001993	active site
355276001994	catalytic triad [active]
355276001995	dimer interface [polypeptide binding]; other site
355276001996	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276001997	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276001998	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276001999	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276002000	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
355276002001	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
355276002002	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
355276002003	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
355276002004	ABC1 family; Region: ABC1; cl17513
355276002005	lipoprotein signal peptidase; Provisional; Region: PRK14783
355276002006	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276002007	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276002008	ligand binding site [chemical binding]; other site
355276002009	flexible hinge region; other site
355276002010	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
355276002011	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
355276002012	oligomeric interface; other site
355276002013	putative active site [active]
355276002014	homodimer interface [polypeptide binding]; other site
355276002015	EamA-like transporter family; Region: EamA; pfam00892
355276002016	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
355276002017	EamA-like transporter family; Region: EamA; pfam00892
355276002018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002019	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002020	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002021	bile acid transporter; Region: bass; TIGR00841
355276002022	Sodium Bile acid symporter family; Region: SBF; cl17470
355276002023	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
355276002024	putative acyl-acceptor binding pocket; other site
355276002025	Response regulator receiver domain; Region: Response_reg; pfam00072
355276002026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276002027	active site
355276002028	phosphorylation site [posttranslational modification]
355276002029	intermolecular recognition site; other site
355276002030	dimerization interface [polypeptide binding]; other site
355276002031	CHASE3 domain; Region: CHASE3; pfam05227
355276002032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276002033	dimer interface [polypeptide binding]; other site
355276002034	phosphorylation site [posttranslational modification]
355276002035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276002036	ATP binding site [chemical binding]; other site
355276002037	Mg2+ binding site [ion binding]; other site
355276002038	G-X-G motif; other site
355276002039	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276002040	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276002041	S-adenosylmethionine binding site [chemical binding]; other site
355276002042	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
355276002043	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
355276002044	putative active site [active]
355276002045	putative metal binding site [ion binding]; other site
355276002046	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276002047	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276002048	Leucine rich repeat; Region: LRR_8; pfam13855
355276002049	Leucine rich repeat; Region: LRR_8; pfam13855
355276002050	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
355276002051	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
355276002052	N-terminal plug; other site
355276002053	ligand-binding site [chemical binding]; other site
355276002054	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276002055	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276002056	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
355276002057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002058	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002059	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002060	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002061	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002062	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276002064	Major Facilitator Superfamily; Region: MFS_1; pfam07690
355276002065	putative substrate translocation pore; other site
355276002066	Pirin-related protein [General function prediction only]; Region: COG1741
355276002067	Pirin; Region: Pirin; pfam02678
355276002068	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
355276002069	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276002070	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
355276002071	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
355276002072	G1 box; other site
355276002073	putative GEF interaction site [polypeptide binding]; other site
355276002074	GTP/Mg2+ binding site [chemical binding]; other site
355276002075	Switch I region; other site
355276002076	G2 box; other site
355276002077	G3 box; other site
355276002078	Switch II region; other site
355276002079	G4 box; other site
355276002080	G5 box; other site
355276002081	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
355276002082	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
355276002083	DnaJ domain; Region: DnaJ; pfam00226
355276002084	HSP70 interaction site [polypeptide binding]; other site
355276002085	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14332
355276002086	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
355276002087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276002088	FeS/SAM binding site; other site
355276002089	Predicted permeases [General function prediction only]; Region: COG0795
355276002090	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
355276002091	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
355276002092	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
355276002093	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
355276002094	active site
355276002095	dimer interfaces [polypeptide binding]; other site
355276002096	catalytic residues [active]
355276002097	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
355276002098	oligomeric interface; other site
355276002099	putative active site [active]
355276002100	homodimer interface [polypeptide binding]; other site
355276002101	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
355276002102	putative catalytic residues [active]
355276002103	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
355276002104	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002105	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002106	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002107	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276002108	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
355276002109	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276002110	substrate binding site [chemical binding]; other site
355276002111	oxyanion hole (OAH) forming residues; other site
355276002112	trimer interface [polypeptide binding]; other site
355276002113	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
355276002114	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
355276002115	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276002116	PilZ domain; Region: PilZ; pfam07238
355276002117	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
355276002118	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276002119	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276002120	DNA binding residues [nucleotide binding]
355276002121	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
355276002122	Mg++ binding site [ion binding]; other site
355276002123	putative catalytic motif [active]
355276002124	putative substrate binding site [chemical binding]; other site
355276002125	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
355276002126	dihydrodipicolinate synthase; Region: dapA; TIGR00674
355276002127	dimer interface [polypeptide binding]; other site
355276002128	active site
355276002129	catalytic residue [active]
355276002130	dihydrodipicolinate reductase; Provisional; Region: PRK00048
355276002131	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
355276002132	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
355276002133	Uncharacterized conserved protein [Function unknown]; Region: COG1624
355276002134	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
355276002135	YbbR-like protein; Region: YbbR; pfam07949
355276002136	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
355276002137	TPR repeat; Region: TPR_11; pfam13414
355276002138	binding surface
355276002139	Tetratricopeptide repeat; Region: TPR_2; pfam07719
355276002140	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
355276002141	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
355276002142	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
355276002143	rRNA interaction site [nucleotide binding]; other site
355276002144	S8 interaction site; other site
355276002145	putative laminin-1 binding site; other site
355276002146	elongation factor Ts; Reviewed; Region: tsf; PRK12332
355276002147	UBA/TS-N domain; Region: UBA; pfam00627
355276002148	Elongation factor TS; Region: EF_TS; pfam00889
355276002149	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
355276002150	putative nucleotide binding site [chemical binding]; other site
355276002151	uridine monophosphate binding site [chemical binding]; other site
355276002152	homohexameric interface [polypeptide binding]; other site
355276002153	ribosome recycling factor; Reviewed; Region: frr; PRK00083
355276002154	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
355276002155	hinge region; other site
355276002156	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14842
355276002157	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
355276002158	catalytic residue [active]
355276002159	putative FPP diphosphate  binding site; other site
355276002160	putative FPP binding hydrophobic cleft; other site
355276002161	dimer interface [polypeptide binding]; other site
355276002162	putative IPP diphosphate binding site; other site
355276002163	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
355276002164	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
355276002165	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
355276002166	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
355276002167	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
355276002168	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
355276002169	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
355276002170	active site
355276002171	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
355276002172	RIP metalloprotease RseP; Region: TIGR00054
355276002173	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
355276002174	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
355276002175	putative substrate binding region [chemical binding]; other site
355276002176	prolyl-tRNA synthetase; Provisional; Region: PRK09194
355276002177	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
355276002178	dimer interface [polypeptide binding]; other site
355276002179	motif 1; other site
355276002180	active site
355276002181	motif 2; other site
355276002182	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
355276002183	putative deacylase active site [active]
355276002184	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
355276002185	active site
355276002186	motif 3; other site
355276002187	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
355276002188	anticodon binding site; other site
355276002189	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
355276002190	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
355276002191	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276002192	catalytic residue [active]
355276002193	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
355276002194	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
355276002195	substrate binding site [chemical binding]; other site
355276002196	active site
355276002197	catalytic residues [active]
355276002198	heterodimer interface [polypeptide binding]; other site
355276002199	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276002200	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
355276002201	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276002202	cyclase homology domain; Region: CHD; cd07302
355276002203	nucleotidyl binding site; other site
355276002204	metal binding site [ion binding]; metal-binding site
355276002205	dimer interface [polypeptide binding]; other site
355276002206	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
355276002207	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
355276002208	TPP-binding site; other site
355276002209	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
355276002210	PYR/PP interface [polypeptide binding]; other site
355276002211	dimer interface [polypeptide binding]; other site
355276002212	TPP binding site [chemical binding]; other site
355276002213	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
355276002214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002215	binding surface
355276002216	TPR motif; other site
355276002217	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002218	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002219	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002221	binding surface
355276002222	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276002223	TPR motif; other site
355276002224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002225	binding surface
355276002226	TPR motif; other site
355276002227	Uncharacterized conserved protein [Function unknown]; Region: COG3391
355276002228	NHL repeat; Region: NHL; pfam01436
355276002229	NHL repeat; Region: NHL; pfam01436
355276002230	von Willebrand factor type A domain; Region: VWA_2; pfam13519
355276002231	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276002232	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
355276002233	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
355276002234	NAD(P) binding site [chemical binding]; other site
355276002235	homotetramer interface [polypeptide binding]; other site
355276002236	homodimer interface [polypeptide binding]; other site
355276002237	active site
355276002238	acyl carrier protein; Provisional; Region: acpP; PRK00982
355276002239	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
355276002240	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
355276002241	dimerization interface [polypeptide binding]; other site
355276002242	active site
355276002243	metal binding site [ion binding]; metal-binding site
355276002244	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
355276002245	dsRNA binding site [nucleotide binding]; other site
355276002246	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
355276002247	nudix motif; other site
355276002248	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
355276002249	active site
355276002250	dimer interface [polypeptide binding]; other site
355276002251	metal binding site [ion binding]; metal-binding site
355276002252	Mechanosensitive ion channel; Region: MS_channel; pfam00924
355276002253	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
355276002254	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
355276002255	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
355276002256	active site
355276002257	NAD binding site [chemical binding]; other site
355276002258	metal binding site [ion binding]; metal-binding site
355276002259	Predicted methyltransferases [General function prediction only]; Region: COG0313
355276002260	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
355276002261	putative SAM binding site [chemical binding]; other site
355276002262	putative homodimer interface [polypeptide binding]; other site
355276002263	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
355276002264	NAD synthetase; Provisional; Region: PRK13981
355276002265	multimer interface [polypeptide binding]; other site
355276002266	active site
355276002267	catalytic triad [active]
355276002268	protein interface 1 [polypeptide binding]; other site
355276002269	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
355276002270	homodimer interface [polypeptide binding]; other site
355276002271	NAD binding pocket [chemical binding]; other site
355276002272	ATP binding pocket [chemical binding]; other site
355276002273	Mg binding site [ion binding]; other site
355276002274	active-site loop [active]
355276002275	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
355276002276	active site
355276002277	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
355276002278	Protein export membrane protein; Region: SecD_SecF; cl14618
355276002279	Bacterial Ig-like domain; Region: Big_5; pfam13205
355276002280	Bacterial Ig-like domain; Region: Big_5; pfam13205
355276002281	Bacterial Ig-like domain; Region: Big_5; pfam13205
355276002282	Bacterial Ig-like domain; Region: Big_5; pfam13205
355276002283	Bacterial Ig-like domain; Region: Big_5; pfam13205
355276002284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002285	TPR motif; other site
355276002286	binding surface
355276002287	Outer membrane efflux protein; Region: OEP; pfam02321
355276002288	Outer membrane efflux protein; Region: OEP; pfam02321
355276002289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002290	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002291	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002292	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
355276002293	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
355276002294	lipoyl-biotinyl attachment site [posttranslational modification]; other site
355276002295	HlyD family secretion protein; Region: HlyD_3; pfam13437
355276002296	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
355276002297	FtsX-like permease family; Region: FtsX; pfam02687
355276002298	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
355276002299	FtsX-like permease family; Region: FtsX; pfam02687
355276002300	Stage II sporulation protein; Region: SpoIID; pfam08486
355276002301	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
355276002302	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
355276002303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
355276002304	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
355276002305	PIN domain; Region: PIN_3; cl17397
355276002306	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
355276002307	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
355276002308	CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049
355276002309	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
355276002310	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
355276002311	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
355276002312	O-Antigen ligase; Region: Wzy_C; pfam04932
355276002313	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276002314	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276002315	active site
355276002316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
355276002317	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
355276002318	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
355276002319	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276002320	non-specific DNA binding site [nucleotide binding]; other site
355276002321	salt bridge; other site
355276002322	sequence-specific DNA binding site [nucleotide binding]; other site
355276002323	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
355276002324	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
355276002325	putative acyl-acceptor binding pocket; other site
355276002326	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
355276002327	PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393
355276002328	active site
355276002329	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
355276002330	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
355276002331	Response regulator receiver domain; Region: Response_reg; pfam00072
355276002332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276002333	active site
355276002334	phosphorylation site [posttranslational modification]
355276002335	intermolecular recognition site; other site
355276002336	dimerization interface [polypeptide binding]; other site
355276002337	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276002338	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
355276002339	protein binding site [polypeptide binding]; other site
355276002340	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
355276002341	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
355276002342	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
355276002343	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002344	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002345	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002346	Rhodanese Homology Domain; Region: RHOD; smart00450
355276002347	active site residue [active]
355276002348	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
355276002349	active site residue [active]
355276002350	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
355276002351	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276002352	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276002353	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
355276002354	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
355276002355	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
355276002356	putative SAM binding site [chemical binding]; other site
355276002357	homodimer interface [polypeptide binding]; other site
355276002358	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
355276002359	active site
355276002360	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
355276002361	hydrophobic ligand binding site; other site
355276002362	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
355276002363	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276002364	non-specific DNA binding site [nucleotide binding]; other site
355276002365	salt bridge; other site
355276002366	sequence-specific DNA binding site [nucleotide binding]; other site
355276002367	Cupin domain; Region: Cupin_2; pfam07883
355276002368	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
355276002369	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
355276002370	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
355276002371	transmembrane helices; other site
355276002372	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
355276002373	metal binding site 2 [ion binding]; metal-binding site
355276002374	putative DNA binding helix; other site
355276002375	metal binding site 1 [ion binding]; metal-binding site
355276002376	dimer interface [polypeptide binding]; other site
355276002377	structural Zn2+ binding site [ion binding]; other site
355276002378	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
355276002379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
355276002380	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
355276002381	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
355276002382	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
355276002383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002384	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002385	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002386	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
355276002387	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
355276002388	Leucine-rich repeats; other site
355276002389	Substrate binding site [chemical binding]; other site
355276002390	Leucine rich repeat; Region: LRR_8; pfam13855
355276002391	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276002392	Leucine rich repeat; Region: LRR_8; pfam13855
355276002393	Leucine rich repeat; Region: LRR_8; pfam13855
355276002394	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
355276002395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276002396	S-adenosylmethionine binding site [chemical binding]; other site
355276002397	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
355276002398	Protein of unknown function (DUF342); Region: DUF342; pfam03961
355276002399	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
355276002400	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
355276002401	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
355276002402	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
355276002403	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
355276002404	ornithine carbamoyltransferase; Provisional; Region: PRK14804
355276002405	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
355276002406	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
355276002407	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
355276002408	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
355276002409	G1 box; other site
355276002410	putative GEF interaction site [polypeptide binding]; other site
355276002411	GTP/Mg2+ binding site [chemical binding]; other site
355276002412	Switch I region; other site
355276002413	G2 box; other site
355276002414	G3 box; other site
355276002415	Switch II region; other site
355276002416	G4 box; other site
355276002417	G5 box; other site
355276002418	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
355276002419	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
355276002420	Histidine kinase; Region: HisKA_2; pfam07568
355276002421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276002422	Mg2+ binding site [ion binding]; other site
355276002423	G-X-G motif; other site
355276002424	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
355276002425	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
355276002426	Histidine kinase; Region: HisKA_2; pfam07568
355276002427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
355276002428	ATP binding site [chemical binding]; other site
355276002429	Mg2+ binding site [ion binding]; other site
355276002430	G-X-G motif; other site
355276002431	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
355276002432	Cysteine-rich domain; Region: CCG; pfam02754
355276002433	Cysteine-rich domain; Region: CCG; pfam02754
355276002434	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276002435	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
355276002436	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276002437	FeS/SAM binding site; other site
355276002438	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
355276002439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
355276002440	metal binding site [ion binding]; metal-binding site
355276002441	active site
355276002442	I-site; other site
355276002443	Sporulation and spore germination; Region: Germane; pfam10646
355276002444	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
355276002445	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
355276002446	motif II; other site
355276002447	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
355276002448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
355276002449	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
355276002450	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276002451	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
355276002452	Protein of unknown function, DUF393; Region: DUF393; cl01136
355276002453	PAS domain S-box; Region: sensory_box; TIGR00229
355276002454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276002455	putative active site [active]
355276002456	heme pocket [chemical binding]; other site
355276002457	PAS domain; Region: PAS_9; pfam13426
355276002458	PAS domain S-box; Region: sensory_box; TIGR00229
355276002459	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276002460	putative active site [active]
355276002461	heme pocket [chemical binding]; other site
355276002462	PAS domain S-box; Region: sensory_box; TIGR00229
355276002463	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276002464	putative active site [active]
355276002465	heme pocket [chemical binding]; other site
355276002466	PAS domain S-box; Region: sensory_box; TIGR00229
355276002467	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276002468	putative active site [active]
355276002469	heme pocket [chemical binding]; other site
355276002470	PAS domain S-box; Region: sensory_box; TIGR00229
355276002471	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276002472	putative active site [active]
355276002473	heme pocket [chemical binding]; other site
355276002474	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276002475	GAF domain; Region: GAF; pfam01590
355276002476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276002477	dimer interface [polypeptide binding]; other site
355276002478	phosphorylation site [posttranslational modification]
355276002479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276002480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276002481	ATP binding site [chemical binding]; other site
355276002482	Mg2+ binding site [ion binding]; other site
355276002483	G-X-G motif; other site
355276002484	TPR repeat; Region: TPR_11; pfam13414
355276002485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002486	binding surface
355276002487	TPR motif; other site
355276002488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002489	binding surface
355276002490	TPR repeat; Region: TPR_11; pfam13414
355276002491	TPR motif; other site
355276002492	TPR repeat; Region: TPR_11; pfam13414
355276002493	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
355276002494	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
355276002495	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
355276002496	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
355276002497	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
355276002498	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276002499	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276002500	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
355276002501	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
355276002502	active site
355276002503	NTP binding site [chemical binding]; other site
355276002504	metal binding triad [ion binding]; metal-binding site
355276002505	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
355276002506	DHH family; Region: DHH; pfam01368
355276002507	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
355276002508	DHHA1 domain; Region: DHHA1; pfam02272
355276002509	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
355276002510	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
355276002511	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
355276002512	RuvA N terminal domain; Region: RuvA_N; pfam01330
355276002513	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002514	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002515	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002516	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
355276002517	DNA methylase; Region: N6_N4_Mtase; pfam01555
355276002518	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
355276002519	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
355276002520	UGMP family protein; Validated; Region: PRK09604
355276002521	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
355276002522	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
355276002523	C-terminal peptidase (prc); Region: prc; TIGR00225
355276002524	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
355276002525	protein binding site [polypeptide binding]; other site
355276002526	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
355276002527	Catalytic dyad [active]
355276002528	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
355276002529	LexA repressor; Validated; Region: PRK00215
355276002530	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
355276002531	Catalytic site [active]
355276002532	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002533	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002534	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002535	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
355276002536	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
355276002537	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
355276002538	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
355276002539	Thymidylate synthase complementing protein; Region: Thy1; cl03630
355276002540	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
355276002541	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
355276002542	metal binding site [ion binding]; metal-binding site
355276002543	dimer interface [polypeptide binding]; other site
355276002544	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
355276002545	Methyltransferase domain; Region: Methyltransf_26; pfam13659
355276002546	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
355276002547	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
355276002548	putative active site [active]
355276002549	putative NTP binding site [chemical binding]; other site
355276002550	putative nucleic acid binding site [nucleotide binding]; other site
355276002551	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
355276002552	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276002553	non-specific DNA binding site [nucleotide binding]; other site
355276002554	salt bridge; other site
355276002555	sequence-specific DNA binding site [nucleotide binding]; other site
355276002556	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
355276002557	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276002558	non-specific DNA binding site [nucleotide binding]; other site
355276002559	salt bridge; other site
355276002560	sequence-specific DNA binding site [nucleotide binding]; other site
355276002561	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816
355276002562	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
355276002563	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
355276002564	SAF-like; Region: SAF_2; pfam13144
355276002565	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
355276002566	Flagellar L-ring protein; Region: FlgH; cl17277
355276002567	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
355276002568	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
355276002569	Rod binding protein; Region: Rod-binding; pfam10135
355276002570	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276002571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276002572	S-adenosylmethionine binding site [chemical binding]; other site
355276002573	Methyltransferase domain; Region: Methyltransf_11; pfam08241
355276002574	S-adenosylmethionine binding site [chemical binding]; other site
355276002575	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
355276002576	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
355276002577	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
355276002578	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
355276002579	ring oligomerisation interface [polypeptide binding]; other site
355276002580	ATP/Mg binding site [chemical binding]; other site
355276002581	stacking interactions; other site
355276002582	hinge regions; other site
355276002583	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
355276002584	oligomerisation interface [polypeptide binding]; other site
355276002585	mobile loop; other site
355276002586	roof hairpin; other site
355276002587	hypothetical protein; Provisional; Region: PRK10030
355276002588	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276002589	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
355276002590	cyclase homology domain; Region: CHD; cd07302
355276002591	nucleotidyl binding site; other site
355276002592	metal binding site [ion binding]; metal-binding site
355276002593	dimer interface [polypeptide binding]; other site
355276002594	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
355276002595	NADH(P)-binding; Region: NAD_binding_10; pfam13460
355276002596	NAD binding site [chemical binding]; other site
355276002597	active site
355276002598	TOBE domain; Region: TOBE_2; pfam08402
355276002599	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
355276002600	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
355276002601	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
355276002602	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
355276002603	Walker A motif; other site
355276002604	ATP binding site [chemical binding]; other site
355276002605	Walker B motif; other site
355276002606	flagellar assembly protein H; Validated; Region: fliH; PRK06669
355276002607	Flagellar assembly protein FliH; Region: FliH; pfam02108
355276002608	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
355276002609	FliG C-terminal domain; Region: FliG_C; pfam01706
355276002610	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
355276002611	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
355276002612	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
355276002613	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276002614	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
355276002615	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276002616	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276002617	NeuB family; Region: NeuB; pfam03102
355276002618	Sulfatase; Region: Sulfatase; pfam00884
355276002619	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
355276002620	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
355276002621	G1 box; other site
355276002622	GTP/Mg2+ binding site [chemical binding]; other site
355276002623	Switch I region; other site
355276002624	G2 box; other site
355276002625	G3 box; other site
355276002626	Switch II region; other site
355276002627	G4 box; other site
355276002628	G5 box; other site
355276002629	Nucleoside recognition; Region: Gate; pfam07670
355276002630	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
355276002631	Nucleoside recognition; Region: Gate; pfam07670
355276002632	FeoA domain; Region: FeoA; pfam04023
355276002633	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
355276002634	ABC1 family; Region: ABC1; pfam03109
355276002635	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
355276002636	active site
355276002637	ATP binding site [chemical binding]; other site
355276002638	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
355276002639	HAMP domain; Region: HAMP; pfam00672
355276002640	dimerization interface [polypeptide binding]; other site
355276002641	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276002642	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276002643	dimer interface [polypeptide binding]; other site
355276002644	putative CheW interface [polypeptide binding]; other site
355276002645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002646	binding surface
355276002647	TPR motif; other site
355276002648	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276002649	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002650	binding surface
355276002651	TPR motif; other site
355276002652	TPR repeat; Region: TPR_11; pfam13414
355276002653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276002654	binding surface
355276002655	TPR motif; other site
355276002656	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
355276002657	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
355276002658	PYR/PP interface [polypeptide binding]; other site
355276002659	dimer interface [polypeptide binding]; other site
355276002660	TPP binding site [chemical binding]; other site
355276002661	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
355276002662	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
355276002663	TPP-binding site [chemical binding]; other site
355276002664	dimer interface [polypeptide binding]; other site
355276002665	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
355276002666	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
355276002667	putative valine binding site [chemical binding]; other site
355276002668	dimer interface [polypeptide binding]; other site
355276002669	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
355276002670	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
355276002671	active site
355276002672	coproporphyrinogen III oxidase; Provisional; Region: PRK06294
355276002673	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276002674	FeS/SAM binding site; other site
355276002675	HemN C-terminal domain; Region: HemN_C; pfam06969
355276002676	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
355276002677	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
355276002678	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
355276002679	active site
355276002680	catalytic triad [active]
355276002681	oxyanion hole [active]
355276002682	switch loop; other site
355276002683	trigger factor; Region: tig; TIGR00115
355276002684	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
355276002685	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
355276002686	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
355276002687	oligomer interface [polypeptide binding]; other site
355276002688	active site residues [active]
355276002689	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
355276002690	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
355276002691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276002692	Walker A motif; other site
355276002693	ATP binding site [chemical binding]; other site
355276002694	Walker B motif; other site
355276002695	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
355276002696	Phosphate transporter family; Region: PHO4; cl00396
355276002697	Phosphate transporter family; Region: PHO4; cl00396
355276002698	serine/threonine protein kinase; Provisional; Region: PRK11768
355276002699	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002700	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002701	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002702	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
355276002703	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
355276002704	putative active site; other site
355276002705	catalytic residue [active]
355276002706	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
355276002707	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
355276002708	dimer interface [polypeptide binding]; other site
355276002709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276002710	catalytic residue [active]
355276002711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002712	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002713	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002714	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
355276002715	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
355276002716	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
355276002717	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
355276002718	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
355276002719	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
355276002720	Cu(I) binding site [ion binding]; other site
355276002721	Protein of unknown function, DUF486; Region: DUF486; cl01236
355276002722	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
355276002723	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
355276002724	putative dimer interface [polypeptide binding]; other site
355276002725	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
355276002726	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
355276002727	putative dimer interface [polypeptide binding]; other site
355276002728	Beta-propeller repeat; Region: SBBP; pfam06739
355276002729	Beta-propeller repeat; Region: SBBP; pfam06739
355276002730	Beta-propeller repeat; Region: SBBP; pfam06739
355276002731	Beta-propeller repeat; Region: SBBP; pfam06739
355276002732	Beta-propeller repeat; Region: SBBP; pfam06739
355276002733	Beta-propeller repeat; Region: SBBP; pfam06739
355276002734	Beta-propeller repeat; Region: SBBP; pfam06739
355276002735	Beta-propeller repeat; Region: SBBP; pfam06739
355276002736	Beta-propeller repeat; Region: SBBP; pfam06739
355276002737	Beta-propeller repeat; Region: SBBP; pfam06739
355276002738	Beta-propeller repeat; Region: SBBP; pfam06739
355276002739	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
355276002740	putative DNA binding site [nucleotide binding]; other site
355276002741	putative Zn2+ binding site [ion binding]; other site
355276002742	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
355276002743	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
355276002744	NADP binding site [chemical binding]; other site
355276002745	active site
355276002746	putative substrate binding site [chemical binding]; other site
355276002747	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH3; cd08184
355276002748	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
355276002749	putative active site [active]
355276002750	metal binding site [ion binding]; metal-binding site
355276002751	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276002752	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
355276002753	active site
355276002754	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
355276002755	NeuB family; Region: NeuB; pfam03102
355276002756	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
355276002757	NeuB binding interface [polypeptide binding]; other site
355276002758	putative substrate binding site [chemical binding]; other site
355276002759	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
355276002760	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
355276002761	ligand binding site; other site
355276002762	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
355276002763	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
355276002764	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
355276002765	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
355276002766	inhibitor-cofactor binding pocket; inhibition site
355276002767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276002768	catalytic residue [active]
355276002769	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
355276002770	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
355276002771	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
355276002772	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
355276002773	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
355276002774	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
355276002775	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
355276002776	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
355276002777	inhibitor-cofactor binding pocket; inhibition site
355276002778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276002779	catalytic residue [active]
355276002780	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
355276002781	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
355276002782	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
355276002783	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
355276002784	putative NAD(P) binding site [chemical binding]; other site
355276002785	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
355276002786	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
355276002787	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276002788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276002789	S-adenosylmethionine binding site [chemical binding]; other site
355276002790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276002791	S-adenosylmethionine binding site [chemical binding]; other site
355276002792	M28 Zn-Peptidases; Region: M28_like_7; cd05643
355276002793	putative metal binding site [ion binding]; other site
355276002794	Peptidase family M28; Region: Peptidase_M28; pfam04389
355276002795	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
355276002796	ligand binding site; other site
355276002797	classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930
355276002798	flagellin modification protein A; Provisional; Region: PRK09186
355276002799	putative NAD(P) binding site [chemical binding]; other site
355276002800	active site
355276002801	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
355276002802	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
355276002803	active site
355276002804	catalytic tetrad [active]
355276002805	NeuB family; Region: NeuB; pfam03102
355276002806	WbqC-like protein family; Region: WbqC; pfam08889
355276002807	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
355276002808	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
355276002809	inhibitor-cofactor binding pocket; inhibition site
355276002810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276002811	catalytic residue [active]
355276002812	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
355276002813	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
355276002814	Walker A/P-loop; other site
355276002815	ATP binding site [chemical binding]; other site
355276002816	Q-loop/lid; other site
355276002817	ABC transporter signature motif; other site
355276002818	Walker B; other site
355276002819	D-loop; other site
355276002820	H-loop/switch region; other site
355276002821	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
355276002822	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
355276002823	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
355276002824	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
355276002825	putative active site [active]
355276002826	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
355276002827	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
355276002828	dimer interface [polypeptide binding]; other site
355276002829	active site
355276002830	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
355276002831	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
355276002832	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
355276002833	Ligand binding site; other site
355276002834	oligomer interface; other site
355276002835	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
355276002836	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
355276002837	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
355276002838	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
355276002839	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
355276002840	active site
355276002841	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002842	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002843	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002844	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
355276002845	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
355276002846	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
355276002847	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
355276002848	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276002849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276002850	S-adenosylmethionine binding site [chemical binding]; other site
355276002851	alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175
355276002852	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
355276002853	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
355276002854	putative ligand binding site [chemical binding]; other site
355276002855	putative NAD binding site [chemical binding]; other site
355276002856	catalytic site [active]
355276002857	surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326
355276002858	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
355276002859	active site
355276002860	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
355276002861	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
355276002862	Ligand Binding Site [chemical binding]; other site
355276002863	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
355276002864	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
355276002865	putative active site [active]
355276002866	oxyanion strand; other site
355276002867	catalytic triad [active]
355276002868	imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033
355276002869	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
355276002870	substrate binding site [chemical binding]; other site
355276002871	glutamase interaction surface [polypeptide binding]; other site
355276002872	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276002873	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
355276002874	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
355276002875	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
355276002876	NAD binding site [chemical binding]; other site
355276002877	substrate binding site [chemical binding]; other site
355276002878	active site
355276002879	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
355276002880	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
355276002881	Substrate binding site; other site
355276002882	metal-binding site
355276002883	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
355276002884	extended (e) SDRs; Region: SDR_e; cd08946
355276002885	NAD(P) binding site [chemical binding]; other site
355276002886	active site
355276002887	substrate binding site [chemical binding]; other site
355276002888	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
355276002889	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
355276002890	NADP binding site [chemical binding]; other site
355276002891	active site
355276002892	putative substrate binding site [chemical binding]; other site
355276002893	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
355276002894	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
355276002895	NAD(P) binding site [chemical binding]; other site
355276002896	homodimer interface [polypeptide binding]; other site
355276002897	substrate binding site [chemical binding]; other site
355276002898	active site
355276002899	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
355276002900	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
355276002901	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
355276002902	active site
355276002903	homodimer interface [polypeptide binding]; other site
355276002904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276002905	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
355276002906	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
355276002907	Bacterial sugar transferase; Region: Bac_transf; pfam02397
355276002908	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
355276002909	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
355276002910	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
355276002911	active site
355276002912	putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325
355276002913	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276002914	active site
355276002915	WxcM-like, C-terminal; Region: FdtA; pfam05523
355276002916	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
355276002917	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
355276002918	inhibitor-cofactor binding pocket; inhibition site
355276002919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276002920	catalytic residue [active]
355276002921	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276002922	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
355276002923	metal-binding site
355276002924	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276002925	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276002926	active site
355276002927	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
355276002928	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276002929	Probable Catalytic site; other site
355276002930	metal-binding site
355276002931	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276002932	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
355276002933	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
355276002934	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
355276002935	NADP binding site [chemical binding]; other site
355276002936	active site
355276002937	putative substrate binding site [chemical binding]; other site
355276002938	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
355276002939	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
355276002940	NAD binding site [chemical binding]; other site
355276002941	substrate binding site [chemical binding]; other site
355276002942	homodimer interface [polypeptide binding]; other site
355276002943	active site
355276002944	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
355276002945	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
355276002946	substrate binding site; other site
355276002947	tetramer interface; other site
355276002948	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
355276002949	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
355276002950	Probable Catalytic site; other site
355276002951	metal-binding site
355276002952	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
355276002953	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
355276002954	Ligand binding site; other site
355276002955	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276002956	active site
355276002957	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
355276002958	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276002959	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
355276002960	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
355276002961	transmembrane helices; other site
355276002962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276002963	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276002964	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276002965	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
355276002966	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
355276002967	putative active site [active]
355276002968	putative metal binding site [ion binding]; other site
355276002969	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
355276002970	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
355276002971	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
355276002972	dimer interface [polypeptide binding]; other site
355276002973	ssDNA binding site [nucleotide binding]; other site
355276002974	tetramer (dimer of dimers) interface [polypeptide binding]; other site
355276002975	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
355276002976	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
355276002977	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
355276002978	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
355276002979	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
355276002980	replicative DNA helicase; Region: DnaB; TIGR00665
355276002981	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
355276002982	Walker A motif; other site
355276002983	ATP binding site [chemical binding]; other site
355276002984	Walker B motif; other site
355276002985	DNA binding loops [nucleotide binding]
355276002986	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
355276002987	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
355276002988	dimer interface [polypeptide binding]; other site
355276002989	anticodon binding site; other site
355276002990	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
355276002991	homodimer interface [polypeptide binding]; other site
355276002992	motif 1; other site
355276002993	active site
355276002994	motif 2; other site
355276002995	GAD domain; Region: GAD; pfam02938
355276002996	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
355276002997	active site
355276002998	motif 3; other site
355276002999	PhoH-like protein; Region: PhoH; pfam02562
355276003000	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
355276003001	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
355276003002	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276003003	Zn2+ binding site [ion binding]; other site
355276003004	Mg2+ binding site [ion binding]; other site
355276003005	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
355276003006	Recombination protein O N terminal; Region: RecO_N; pfam11967
355276003007	DNA repair protein RecO; Region: reco; TIGR00613
355276003008	Recombination protein O C terminal; Region: RecO_C; pfam02565
355276003009	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
355276003010	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
355276003011	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
355276003012	active site
355276003013	HIGH motif; other site
355276003014	nucleotide binding site [chemical binding]; other site
355276003015	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
355276003016	KMSK motif region; other site
355276003017	DALR anticodon binding domain; Region: DALR_1; smart00836
355276003018	anticodon binding site; other site
355276003019	tRNA binding surface [nucleotide binding]; other site
355276003020	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
355276003021	competence damage-inducible protein A; Provisional; Region: PRK00549
355276003022	putative MPT binding site; other site
355276003023	Competence-damaged protein; Region: CinA; pfam02464
355276003024	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
355276003025	Helix-turn-helix domain; Region: HTH_19; pfam12844
355276003026	non-specific DNA binding site [nucleotide binding]; other site
355276003027	salt bridge; other site
355276003028	sequence-specific DNA binding site [nucleotide binding]; other site
355276003029	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
355276003030	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276003031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003032	active site
355276003033	phosphorylation site [posttranslational modification]
355276003034	intermolecular recognition site; other site
355276003035	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
355276003036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276003037	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276003038	dimer interface [polypeptide binding]; other site
355276003039	phosphorylation site [posttranslational modification]
355276003040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003041	ATP binding site [chemical binding]; other site
355276003042	Mg2+ binding site [ion binding]; other site
355276003043	G-X-G motif; other site
355276003044	triosephosphate isomerase; Provisional; Region: PRK14567
355276003045	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
355276003046	substrate binding site [chemical binding]; other site
355276003047	dimer interface [polypeptide binding]; other site
355276003048	catalytic triad [active]
355276003049	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
355276003050	Phosphoglycerate kinase; Region: PGK; pfam00162
355276003051	substrate binding site [chemical binding]; other site
355276003052	hinge regions; other site
355276003053	ADP binding site [chemical binding]; other site
355276003054	catalytic site [active]
355276003055	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
355276003056	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
355276003057	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
355276003058	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276003059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003060	active site
355276003061	phosphorylation site [posttranslational modification]
355276003062	intermolecular recognition site; other site
355276003063	dimerization interface [polypeptide binding]; other site
355276003064	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
355276003065	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
355276003066	Catalytic site [active]
355276003067	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
355276003068	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
355276003069	trimer interface [polypeptide binding]; other site
355276003070	putative metal binding site [ion binding]; other site
355276003071	glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207
355276003072	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
355276003073	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
355276003074	dimer interface [polypeptide binding]; other site
355276003075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276003076	catalytic residue [active]
355276003077	DNA topoisomerase I; Validated; Region: PRK05582
355276003078	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
355276003079	active site
355276003080	interdomain interaction site; other site
355276003081	putative metal-binding site [ion binding]; other site
355276003082	nucleotide binding site [chemical binding]; other site
355276003083	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
355276003084	domain I; other site
355276003085	DNA binding groove [nucleotide binding]
355276003086	phosphate binding site [ion binding]; other site
355276003087	domain II; other site
355276003088	domain III; other site
355276003089	nucleotide binding site [chemical binding]; other site
355276003090	catalytic site [active]
355276003091	domain IV; other site
355276003092	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
355276003093	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
355276003094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276003095	Walker A/P-loop; other site
355276003096	ATP binding site [chemical binding]; other site
355276003097	Q-loop/lid; other site
355276003098	ABC transporter signature motif; other site
355276003099	Walker B; other site
355276003100	D-loop; other site
355276003101	H-loop/switch region; other site
355276003102	HDOD domain; Region: HDOD; pfam08668
355276003103	HD domain; Region: HD; pfam01966
355276003104	putative inner membrane protein translocase component YidC; Validated; Region: PRK00247
355276003105	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
355276003106	tetramerization interface [polypeptide binding]; other site
355276003107	active site
355276003108	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
355276003109	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
355276003110	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276003111	anti sigma factor interaction site; other site
355276003112	regulatory phosphorylation site [posttranslational modification]; other site
355276003113	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
355276003114	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
355276003115	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
355276003116	Transcriptional regulators [Transcription]; Region: MarR; COG1846
355276003117	MarR family; Region: MarR_2; pfam12802
355276003118	MarR family; Region: MarR_2; cl17246
355276003119	SnoaL-like domain; Region: SnoaL_2; pfam12680
355276003120	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
355276003121	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
355276003122	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
355276003123	putative acyl-acceptor binding pocket; other site
355276003124	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
355276003125	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
355276003126	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
355276003127	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
355276003128	CheB methylesterase; Region: CheB_methylest; pfam01339
355276003129	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
355276003130	HAMP domain; Region: HAMP; pfam00672
355276003131	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276003132	GAF domain; Region: GAF; pfam01590
355276003133	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276003134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276003135	dimer interface [polypeptide binding]; other site
355276003136	phosphorylation site [posttranslational modification]
355276003137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003138	ATP binding site [chemical binding]; other site
355276003139	Mg2+ binding site [ion binding]; other site
355276003140	G-X-G motif; other site
355276003141	Response regulator receiver domain; Region: Response_reg; pfam00072
355276003142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003143	active site
355276003144	phosphorylation site [posttranslational modification]
355276003145	intermolecular recognition site; other site
355276003146	dimerization interface [polypeptide binding]; other site
355276003147	Response regulator receiver domain; Region: Response_reg; pfam00072
355276003148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003149	active site
355276003150	phosphorylation site [posttranslational modification]
355276003151	intermolecular recognition site; other site
355276003152	Response regulator receiver domain; Region: Response_reg; pfam00072
355276003153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003154	active site
355276003155	phosphorylation site [posttranslational modification]
355276003156	intermolecular recognition site; other site
355276003157	dimerization interface [polypeptide binding]; other site
355276003158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276003159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003160	active site
355276003161	phosphorylation site [posttranslational modification]
355276003162	intermolecular recognition site; other site
355276003163	dimerization interface [polypeptide binding]; other site
355276003164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276003165	dimer interface [polypeptide binding]; other site
355276003166	phosphorylation site [posttranslational modification]
355276003167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003168	ATP binding site [chemical binding]; other site
355276003169	Mg2+ binding site [ion binding]; other site
355276003170	G-X-G motif; other site
355276003171	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276003172	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
355276003173	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276003174	non-specific DNA binding site [nucleotide binding]; other site
355276003175	salt bridge; other site
355276003176	sequence-specific DNA binding site [nucleotide binding]; other site
355276003177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276003178	non-specific DNA binding site [nucleotide binding]; other site
355276003179	salt bridge; other site
355276003180	sequence-specific DNA binding site [nucleotide binding]; other site
355276003181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276003182	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276003183	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276003184	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
355276003185	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
355276003186	Leucine-rich repeats; other site
355276003187	Substrate binding site [chemical binding]; other site
355276003188	Leucine rich repeat; Region: LRR_8; pfam13855
355276003189	Leucine rich repeat; Region: LRR_8; pfam13855
355276003190	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
355276003191	FliG C-terminal domain; Region: FliG_C; pfam01706
355276003192	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
355276003193	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
355276003194	E3 interaction surface; other site
355276003195	lipoyl attachment site [posttranslational modification]; other site
355276003196	e3 binding domain; Region: E3_binding; pfam02817
355276003197	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
355276003198	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
355276003199	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
355276003200	alpha subunit interface [polypeptide binding]; other site
355276003201	TPP binding site [chemical binding]; other site
355276003202	heterodimer interface [polypeptide binding]; other site
355276003203	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
355276003204	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
355276003205	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
355276003206	tetramer interface [polypeptide binding]; other site
355276003207	TPP-binding site [chemical binding]; other site
355276003208	heterodimer interface [polypeptide binding]; other site
355276003209	phosphorylation loop region [posttranslational modification]
355276003210	DNA-binding response regulator CreB; Provisional; Region: PRK11083
355276003211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003212	active site
355276003213	phosphorylation site [posttranslational modification]
355276003214	intermolecular recognition site; other site
355276003215	dimerization interface [polypeptide binding]; other site
355276003216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
355276003217	DNA binding site [nucleotide binding]
355276003218	sensory histidine kinase CreC; Provisional; Region: PRK11100
355276003219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003220	ATP binding site [chemical binding]; other site
355276003221	Mg2+ binding site [ion binding]; other site
355276003222	G-X-G motif; other site
355276003223	inner membrane protein; Provisional; Region: PRK11715
355276003224	flagellin; Provisional; Region: PRK12804
355276003225	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
355276003226	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
355276003227	flagellin; Provisional; Region: PRK12804
355276003228	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
355276003229	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
355276003230	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
355276003231	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
355276003232	Peptidase family M48; Region: Peptidase_M48; cl12018
355276003233	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
355276003234	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
355276003235	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
355276003236	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
355276003237	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
355276003238	mce related protein; Region: MCE; pfam02470
355276003239	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
355276003240	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
355276003241	Walker A/P-loop; other site
355276003242	ATP binding site [chemical binding]; other site
355276003243	Q-loop/lid; other site
355276003244	ABC transporter signature motif; other site
355276003245	Walker B; other site
355276003246	D-loop; other site
355276003247	H-loop/switch region; other site
355276003248	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
355276003249	Permease; Region: Permease; pfam02405
355276003250	D-alanyl-alanine synthetase A; Provisional; Region: PRK14572
355276003251	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
355276003252	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276003253	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276003254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276003255	S-adenosylmethionine binding site [chemical binding]; other site
355276003256	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
355276003257	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
355276003258	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
355276003259	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
355276003260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276003261	Walker A motif; other site
355276003262	ATP binding site [chemical binding]; other site
355276003263	Walker B motif; other site
355276003264	arginine finger; other site
355276003265	flagellar motor switch protein FliN; Region: fliN; TIGR02480
355276003266	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
355276003267	HflC protein; Region: hflC; TIGR01932
355276003268	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
355276003269	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
355276003270	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
355276003271	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
355276003272	Haem-binding domain; Region: Haem_bd; pfam14376
355276003273	argininosuccinate lyase; Provisional; Region: PRK00855
355276003274	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
355276003275	active sites [active]
355276003276	tetramer interface [polypeptide binding]; other site
355276003277	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
355276003278	active site
355276003279	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
355276003280	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
355276003281	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
355276003282	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
355276003283	FecR protein; Region: FecR; pfam04773
355276003284	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
355276003285	Uncharacterized conserved protein [Function unknown]; Region: COG4095
355276003286	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
355276003287	GMP synthase; Reviewed; Region: guaA; PRK00074
355276003288	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
355276003289	AMP/PPi binding site [chemical binding]; other site
355276003290	candidate oxyanion hole; other site
355276003291	catalytic triad [active]
355276003292	potential glutamine specificity residues [chemical binding]; other site
355276003293	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
355276003294	ATP Binding subdomain [chemical binding]; other site
355276003295	Ligand Binding sites [chemical binding]; other site
355276003296	Dimerization subdomain; other site
355276003297	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
355276003298	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
355276003299	O-Antigen ligase; Region: Wzy_C; pfam04932
355276003300	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
355276003301	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
355276003302	putative metal binding site; other site
355276003303	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
355276003304	dimer interface [polypeptide binding]; other site
355276003305	active site
355276003306	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
355276003307	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
355276003308	Walker A/P-loop; other site
355276003309	ATP binding site [chemical binding]; other site
355276003310	Q-loop/lid; other site
355276003311	ABC transporter signature motif; other site
355276003312	Walker B; other site
355276003313	D-loop; other site
355276003314	H-loop/switch region; other site
355276003315	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
355276003316	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
355276003317	phosphopeptide binding site; other site
355276003318	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
355276003319	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
355276003320	substrate binding site [chemical binding]; other site
355276003321	ligand binding site [chemical binding]; other site
355276003322	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
355276003323	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
355276003324	substrate binding site [chemical binding]; other site
355276003325	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
355276003326	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
355276003327	dimer interface [polypeptide binding]; other site
355276003328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276003329	catalytic residue [active]
355276003330	DNA helicase, putative; Region: TIGR00376
355276003331	AAA domain; Region: AAA_12; pfam13087
355276003332	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276003333	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276003334	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276003335	DNA binding residues [nucleotide binding]
355276003336	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
355276003337	Protein of unknown function, DUF482; Region: DUF482; pfam04339
355276003338	Uncharacterized conserved protein [Function unknown]; Region: COG2127
355276003339	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
355276003340	Clp amino terminal domain; Region: Clp_N; pfam02861
355276003341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276003342	Walker A motif; other site
355276003343	ATP binding site [chemical binding]; other site
355276003344	Walker B motif; other site
355276003345	arginine finger; other site
355276003346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276003347	Walker A motif; other site
355276003348	ATP binding site [chemical binding]; other site
355276003349	Walker B motif; other site
355276003350	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
355276003351	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
355276003352	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
355276003353	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
355276003354	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
355276003355	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276003356	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
355276003357	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
355276003358	putative GSH binding site [chemical binding]; other site
355276003359	catalytic residues [active]
355276003360	BolA-like protein; Region: BolA; pfam01722
355276003361	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
355276003362	inner membrane transport permease; Provisional; Region: PRK15066
355276003363	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
355276003364	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
355276003365	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
355276003366	Walker A/P-loop; other site
355276003367	ATP binding site [chemical binding]; other site
355276003368	Q-loop/lid; other site
355276003369	ABC transporter signature motif; other site
355276003370	Walker B; other site
355276003371	D-loop; other site
355276003372	H-loop/switch region; other site
355276003373	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
355276003374	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
355276003375	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
355276003376	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
355276003377	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276003378	anti sigma factor interaction site; other site
355276003379	regulatory phosphorylation site [posttranslational modification]; other site
355276003380	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
355276003381	glycerol kinase; Provisional; Region: glpK; PRK00047
355276003382	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
355276003383	N- and C-terminal domain interface [polypeptide binding]; other site
355276003384	active site
355276003385	MgATP binding site [chemical binding]; other site
355276003386	catalytic site [active]
355276003387	metal binding site [ion binding]; metal-binding site
355276003388	glycerol binding site [chemical binding]; other site
355276003389	homotetramer interface [polypeptide binding]; other site
355276003390	homodimer interface [polypeptide binding]; other site
355276003391	FBP binding site [chemical binding]; other site
355276003392	protein IIAGlc interface [polypeptide binding]; other site
355276003393	proline dipeptidase; Provisional; Region: PRK13607
355276003394	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276003395	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276003396	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
355276003397	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
355276003398	tandem repeat interface [polypeptide binding]; other site
355276003399	oligomer interface [polypeptide binding]; other site
355276003400	active site residues [active]
355276003401	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
355276003402	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
355276003403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
355276003404	ATP binding site [chemical binding]; other site
355276003405	putative Mg++ binding site [ion binding]; other site
355276003406	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276003407	nucleotide binding region [chemical binding]; other site
355276003408	ATP-binding site [chemical binding]; other site
355276003409	aspartate aminotransferase; Provisional; Region: PRK05764
355276003410	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276003411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276003412	homodimer interface [polypeptide binding]; other site
355276003413	catalytic residue [active]
355276003414	acyl-CoA esterase; Provisional; Region: PRK10673
355276003415	PGAP1-like protein; Region: PGAP1; pfam07819
355276003416	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
355276003417	Na binding site [ion binding]; other site
355276003418	homoserine kinase; Provisional; Region: PRK01212
355276003419	Thioredoxin; Region: Thioredoxin_4; pfam13462
355276003420	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
355276003421	malate dehydrogenase; Provisional; Region: PRK05442
355276003422	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
355276003423	NAD(P) binding site [chemical binding]; other site
355276003424	dimer interface [polypeptide binding]; other site
355276003425	malate binding site [chemical binding]; other site
355276003426	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
355276003427	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
355276003428	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276003429	catalytic residue [active]
355276003430	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
355276003431	AAA domain; Region: AAA_26; pfam13500
355276003432	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
355276003433	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
355276003434	inhibitor-cofactor binding pocket; inhibition site
355276003435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276003436	catalytic residue [active]
355276003437	biotin synthase; Region: bioB; TIGR00433
355276003438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276003439	FeS/SAM binding site; other site
355276003440	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
355276003441	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
355276003442	active site
355276003443	catalytic triad [active]
355276003444	oxyanion hole [active]
355276003445	phosphoserine phosphatase SerB; Region: serB; TIGR00338
355276003446	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
355276003447	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
355276003448	motif II; other site
355276003449	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
355276003450	MutS domain I; Region: MutS_I; pfam01624
355276003451	MutS domain II; Region: MutS_II; pfam05188
355276003452	MutS domain III; Region: MutS_III; pfam05192
355276003453	MutS domain V; Region: MutS_V; pfam00488
355276003454	Walker A/P-loop; other site
355276003455	ATP binding site [chemical binding]; other site
355276003456	Q-loop/lid; other site
355276003457	ABC transporter signature motif; other site
355276003458	Walker B; other site
355276003459	D-loop; other site
355276003460	H-loop/switch region; other site
355276003461	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
355276003462	active site
355276003463	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
355276003464	Response regulator receiver domain; Region: Response_reg; pfam00072
355276003465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003466	active site
355276003467	phosphorylation site [posttranslational modification]
355276003468	intermolecular recognition site; other site
355276003469	dimerization interface [polypeptide binding]; other site
355276003470	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
355276003471	tartrate dehydrogenase; Region: TTC; TIGR02089
355276003472	acetylornithine aminotransferase; Provisional; Region: PRK02627
355276003473	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
355276003474	inhibitor-cofactor binding pocket; inhibition site
355276003475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276003476	catalytic residue [active]
355276003477	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
355276003478	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
355276003479	active site
355276003480	substrate binding site [chemical binding]; other site
355276003481	metal binding site [ion binding]; metal-binding site
355276003482	transaminase; Validated; Region: PRK07324
355276003483	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276003484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276003485	homodimer interface [polypeptide binding]; other site
355276003486	catalytic residue [active]
355276003487	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
355276003488	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
355276003489	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
355276003490	minor groove reading motif; other site
355276003491	helix-hairpin-helix signature motif; other site
355276003492	substrate binding pocket [chemical binding]; other site
355276003493	active site
355276003494	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
355276003495	RF-1 domain; Region: RF-1; pfam00472
355276003496	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
355276003497	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
355276003498	GIY-YIG motif/motif A; other site
355276003499	active site
355276003500	catalytic site [active]
355276003501	putative DNA binding site [nucleotide binding]; other site
355276003502	metal binding site [ion binding]; metal-binding site
355276003503	UvrB/uvrC motif; Region: UVR; pfam02151
355276003504	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
355276003505	Helix-hairpin-helix motif; Region: HHH; pfam00633
355276003506	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
355276003507	PLD-like domain; Region: PLDc_2; pfam13091
355276003508	putative active site [active]
355276003509	catalytic site [active]
355276003510	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
355276003511	PLD-like domain; Region: PLDc_2; pfam13091
355276003512	putative active site [active]
355276003513	catalytic site [active]
355276003514	Winged helix-turn helix; Region: HTH_29; pfam13551
355276003515	Homeodomain-like domain; Region: HTH_32; pfam13565
355276003516	Winged helix-turn helix; Region: HTH_33; pfam13592
355276003517	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276003518	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
355276003519	putative ADP-binding pocket [chemical binding]; other site
355276003520	O-Antigen ligase; Region: Wzy_C; pfam04932
355276003521	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
355276003522	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
355276003523	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
355276003524	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
355276003525	putative active site [active]
355276003526	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
355276003527	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276003528	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276003529	ligand binding site [chemical binding]; other site
355276003530	flexible hinge region; other site
355276003531	hypothetical protein; Provisional; Region: PRK10279
355276003532	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
355276003533	nucleophile elbow; other site
355276003534	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
355276003535	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276003536	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276003537	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276003538	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
355276003539	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
355276003540	N-terminal plug; other site
355276003541	ligand-binding site [chemical binding]; other site
355276003542	Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375
355276003543	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276003544	outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327
355276003545	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
355276003546	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
355276003547	active site
355276003548	catalytic residues [active]
355276003549	metal binding site [ion binding]; metal-binding site
355276003550	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276003551	GAF domain; Region: GAF; pfam01590
355276003552	GAF domain; Region: GAF_3; pfam13492
355276003553	GAF domain; Region: GAF_2; pfam13185
355276003554	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276003555	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276003556	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276003557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
355276003558	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276003559	anti sigma factor interaction site; other site
355276003560	regulatory phosphorylation site [posttranslational modification]; other site
355276003561	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
355276003562	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
355276003563	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
355276003564	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
355276003565	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276003566	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
355276003567	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
355276003568	carboxyltransferase (CT) interaction site; other site
355276003569	biotinylation site [posttranslational modification]; other site
355276003570	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
355276003571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003572	active site
355276003573	phosphorylation site [posttranslational modification]
355276003574	intermolecular recognition site; other site
355276003575	dimerization interface [polypeptide binding]; other site
355276003576	CheB methylesterase; Region: CheB_methylest; pfam01339
355276003577	CheD chemotactic sensory transduction; Region: CheD; cl00810
355276003578	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
355276003579	PAS fold; Region: PAS; pfam00989
355276003580	PAS domain; Region: PAS; smart00091
355276003581	PAS domain; Region: PAS_10; pfam13596
355276003582	PAS domain; Region: PAS_9; pfam13426
355276003583	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276003584	dimer interface [polypeptide binding]; other site
355276003585	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
355276003586	putative CheW interface [polypeptide binding]; other site
355276003587	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276003588	anti sigma factor interaction site; other site
355276003589	regulatory phosphorylation site [posttranslational modification]; other site
355276003590	Response regulator receiver domain; Region: Response_reg; pfam00072
355276003591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003592	active site
355276003593	phosphorylation site [posttranslational modification]
355276003594	intermolecular recognition site; other site
355276003595	dimerization interface [polypeptide binding]; other site
355276003596	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
355276003597	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
355276003598	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276003599	flagellin; Provisional; Region: PRK12804
355276003600	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
355276003601	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
355276003602	flagellin; Provisional; Region: PRK12804
355276003603	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
355276003604	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
355276003605	ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636
355276003606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276003607	Major Facilitator Superfamily; Region: MFS_1; pfam07690
355276003608	putative substrate translocation pore; other site
355276003609	POT family; Region: PTR2; cl17359
355276003610	NlpC/P60 family; Region: NLPC_P60; pfam00877
355276003611	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
355276003612	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
355276003613	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
355276003614	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
355276003615	active site
355276003616	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
355276003617	TSCPD domain; Region: TSCPD; pfam12637
355276003618	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276003619	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276003620	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276003621	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14069
355276003622	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
355276003623	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
355276003624	generic binding surface II; other site
355276003625	generic binding surface I; other site
355276003626	Domain of unknown function DUF20; Region: UPF0118; pfam01594
355276003627	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
355276003628	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
355276003629	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
355276003630	Uncharacterized conserved protein [Function unknown]; Region: COG4850
355276003631	Smr domain; Region: Smr; pfam01713
355276003632	(R)-citramalate synthase; Provisional; Region: PRK09389
355276003633	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
355276003634	active site
355276003635	catalytic residues [active]
355276003636	metal binding site [ion binding]; metal-binding site
355276003637	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
355276003638	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
355276003639	putative active site [active]
355276003640	catalytic residue [active]
355276003641	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
355276003642	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
355276003643	active site
355276003644	Int/Topo IB signature motif; other site
355276003645	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
355276003646	active site
355276003647	HslU subunit interaction site [polypeptide binding]; other site
355276003648	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
355276003649	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276003650	Walker A motif; other site
355276003651	ATP binding site [chemical binding]; other site
355276003652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276003653	Walker B motif; other site
355276003654	arginine finger; other site
355276003655	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
355276003656	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
355276003657	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
355276003658	E3 interaction surface; other site
355276003659	lipoyl attachment site [posttranslational modification]; other site
355276003660	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
355276003661	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
355276003662	putative active site [active]
355276003663	putative metal binding site [ion binding]; other site
355276003664	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
355276003665	active site
355276003666	metal binding site [ion binding]; metal-binding site
355276003667	Domain of unknown function DUF59; Region: DUF59; pfam01883
355276003668	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
355276003669	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
355276003670	Walker A motif; other site
355276003671	aromatic acid decarboxylase; Validated; Region: PRK05920
355276003672	Flavoprotein; Region: Flavoprotein; pfam02441
355276003673	prenyltransferase; Reviewed; Region: ubiA; PRK12886
355276003674	UbiA prenyltransferase family; Region: UbiA; pfam01040
355276003675	GTP-binding protein YchF; Reviewed; Region: PRK09601
355276003676	YchF GTPase; Region: YchF; cd01900
355276003677	G1 box; other site
355276003678	GTP/Mg2+ binding site [chemical binding]; other site
355276003679	Switch I region; other site
355276003680	G2 box; other site
355276003681	Switch II region; other site
355276003682	G3 box; other site
355276003683	G4 box; other site
355276003684	G5 box; other site
355276003685	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
355276003686	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
355276003687	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
355276003688	minor groove reading motif; other site
355276003689	helix-hairpin-helix signature motif; other site
355276003690	substrate binding pocket [chemical binding]; other site
355276003691	active site
355276003692	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
355276003693	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
355276003694	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
355276003695	NADP binding site [chemical binding]; other site
355276003696	homopentamer interface [polypeptide binding]; other site
355276003697	substrate binding site [chemical binding]; other site
355276003698	active site
355276003699	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
355276003700	dimerization interface [polypeptide binding]; other site
355276003701	putative DNA binding site [nucleotide binding]; other site
355276003702	putative Zn2+ binding site [ion binding]; other site
355276003703	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
355276003704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276003705	NAD(P) binding site [chemical binding]; other site
355276003706	active site
355276003707	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
355276003708	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
355276003709	Walker A/P-loop; other site
355276003710	ATP binding site [chemical binding]; other site
355276003711	Q-loop/lid; other site
355276003712	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
355276003713	ABC transporter signature motif; other site
355276003714	Walker B; other site
355276003715	D-loop; other site
355276003716	H-loop/switch region; other site
355276003717	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
355276003718	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
355276003719	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
355276003720	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
355276003721	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
355276003722	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
355276003723	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
355276003724	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
355276003725	Surface antigen; Region: Bac_surface_Ag; pfam01103
355276003726	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
355276003727	Part of AAA domain; Region: AAA_19; pfam13245
355276003728	Family description; Region: UvrD_C_2; pfam13538
355276003729	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
355276003730	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
355276003731	active site
355276003732	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276003733	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
355276003734	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
355276003735	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
355276003736	catalytic residues [active]
355276003737	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
355276003738	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
355276003739	acyl-activating enzyme (AAE) consensus motif; other site
355276003740	active site
355276003741	AMP binding site [chemical binding]; other site
355276003742	CoA binding site [chemical binding]; other site
355276003743	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
355276003744	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
355276003745	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
355276003746	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
355276003747	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
355276003748	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
355276003749	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
355276003750	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
355276003751	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
355276003752	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
355276003753	biotin synthase; Provisional; Region: PRK08508
355276003754	FecR protein; Region: FecR; pfam04773
355276003755	lipoyl synthase; Provisional; Region: PRK05481
355276003756	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276003757	FeS/SAM binding site; other site
355276003758	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
355276003759	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
355276003760	RNA binding surface [nucleotide binding]; other site
355276003761	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
355276003762	active site
355276003763	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276003764	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
355276003765	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
355276003766	active site
355276003767	intersubunit interactions; other site
355276003768	catalytic residue [active]
355276003769	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
355276003770	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
355276003771	purine monophosphate binding site [chemical binding]; other site
355276003772	dimer interface [polypeptide binding]; other site
355276003773	putative catalytic residues [active]
355276003774	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
355276003775	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
355276003776	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
355276003777	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
355276003778	active site
355276003779	substrate binding site [chemical binding]; other site
355276003780	cosubstrate binding site; other site
355276003781	catalytic site [active]
355276003782	Flagellar protein FliS; Region: FliS; cl00654
355276003783	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
355276003784	HSP70 interaction site [polypeptide binding]; other site
355276003785	nsp8 replicase; Region: nsp8; pfam08717
355276003786	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
355276003787	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
355276003788	active site
355276003789	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
355276003790	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
355276003791	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
355276003792	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276003793	Zn2+ binding site [ion binding]; other site
355276003794	Mg2+ binding site [ion binding]; other site
355276003795	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
355276003796	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
355276003797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276003798	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276003799	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276003800	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
355276003801	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
355276003802	recombinase A; Provisional; Region: recA; PRK09354
355276003803	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
355276003804	hexamer interface [polypeptide binding]; other site
355276003805	Walker A motif; other site
355276003806	ATP binding site [chemical binding]; other site
355276003807	Walker B motif; other site
355276003808	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
355276003809	nucleotide binding site/active site [active]
355276003810	HIT family signature motif; other site
355276003811	catalytic residue [active]
355276003812	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
355276003813	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
355276003814	MG2 domain; Region: A2M_N; pfam01835
355276003815	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
355276003816	Alpha-2-macroglobulin family; Region: A2M; pfam00207
355276003817	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
355276003818	Transglycosylase; Region: Transgly; pfam00912
355276003819	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
355276003820	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
355276003821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276003822	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
355276003823	Walker A motif; other site
355276003824	ATP binding site [chemical binding]; other site
355276003825	Walker B motif; other site
355276003826	arginine finger; other site
355276003827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
355276003828	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
355276003829	Protein of unknown function DUF45; Region: DUF45; cl00636
355276003830	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
355276003831	Part of AAA domain; Region: AAA_19; pfam13245
355276003832	Family description; Region: UvrD_C_2; pfam13538
355276003833	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
355276003834	Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340
355276003835	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
355276003836	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
355276003837	active site
355276003838	FMN binding site [chemical binding]; other site
355276003839	2,4-decadienoyl-CoA binding site; other site
355276003840	catalytic residue [active]
355276003841	4Fe-4S cluster binding site [ion binding]; other site
355276003842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
355276003843	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
355276003844	amidase catalytic site [active]
355276003845	Zn binding residues [ion binding]; other site
355276003846	substrate binding site [chemical binding]; other site
355276003847	2-isopropylmalate synthase; Validated; Region: PRK00915
355276003848	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
355276003849	active site
355276003850	catalytic residues [active]
355276003851	metal binding site [ion binding]; metal-binding site
355276003852	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
355276003853	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
355276003854	Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253
355276003855	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276003856	ligand binding site [chemical binding]; other site
355276003857	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
355276003858	MgtE intracellular N domain; Region: MgtE_N; pfam03448
355276003859	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
355276003860	Divalent cation transporter; Region: MgtE; pfam01769
355276003861	PAS domain; Region: PAS; smart00091
355276003862	PAS fold; Region: PAS_4; pfam08448
355276003863	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276003864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276003865	dimer interface [polypeptide binding]; other site
355276003866	phosphorylation site [posttranslational modification]
355276003867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003868	ATP binding site [chemical binding]; other site
355276003869	Mg2+ binding site [ion binding]; other site
355276003870	G-X-G motif; other site
355276003871	Response regulator receiver domain; Region: Response_reg; pfam00072
355276003872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003873	active site
355276003874	phosphorylation site [posttranslational modification]
355276003875	intermolecular recognition site; other site
355276003876	dimerization interface [polypeptide binding]; other site
355276003877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276003878	dimer interface [polypeptide binding]; other site
355276003879	phosphorylation site [posttranslational modification]
355276003880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003881	ATP binding site [chemical binding]; other site
355276003882	Mg2+ binding site [ion binding]; other site
355276003883	G-X-G motif; other site
355276003884	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276003885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276003886	active site
355276003887	phosphorylation site [posttranslational modification]
355276003888	intermolecular recognition site; other site
355276003889	dimerization interface [polypeptide binding]; other site
355276003890	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276003891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276003892	dimer interface [polypeptide binding]; other site
355276003893	phosphorylation site [posttranslational modification]
355276003894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276003895	ATP binding site [chemical binding]; other site
355276003896	G-X-G motif; other site
355276003897	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
355276003898	AMP binding site [chemical binding]; other site
355276003899	metal binding site [ion binding]; metal-binding site
355276003900	active site
355276003901	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
355276003902	Yqey-like protein; Region: YqeY; pfam09424
355276003903	CHC2 zinc finger; Region: zf-CHC2; pfam01807
355276003904	DNA primase; Validated; Region: dnaG; PRK05667
355276003905	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
355276003906	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
355276003907	active site
355276003908	metal binding site [ion binding]; metal-binding site
355276003909	interdomain interaction site; other site
355276003910	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
355276003911	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
355276003912	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
355276003913	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276003914	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
355276003915	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276003916	DNA binding residues [nucleotide binding]
355276003917	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
355276003918	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
355276003919	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
355276003920	active site
355276003921	HIGH motif; other site
355276003922	dimer interface [polypeptide binding]; other site
355276003923	KMSKS motif; other site
355276003924	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
355276003925	NodB motif; other site
355276003926	active site
355276003927	catalytic site [active]
355276003928	metal binding site [ion binding]; metal-binding site
355276003929	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
355276003930	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
355276003931	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276003932	catalytic residue [active]
355276003933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276003934	TPR motif; other site
355276003935	binding surface
355276003936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276003937	binding surface
355276003938	TPR motif; other site
355276003939	TPR repeat; Region: TPR_11; pfam13414
355276003940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276003941	binding surface
355276003942	TPR motif; other site
355276003943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276003944	binding surface
355276003945	TPR motif; other site
355276003946	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276003947	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
355276003948	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276003949	substrate binding site [chemical binding]; other site
355276003950	oxyanion hole (OAH) forming residues; other site
355276003951	trimer interface [polypeptide binding]; other site
355276003952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276003953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276003954	Protein of unknown function (DUF962); Region: DUF962; cl01879
355276003955	YacP-like NYN domain; Region: NYN_YacP; pfam05991
355276003956	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276003957	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
355276003958	NAD-dependent deacetylase; Provisional; Region: PRK00481
355276003959	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
355276003960	NAD+ binding site [chemical binding]; other site
355276003961	substrate binding site [chemical binding]; other site
355276003962	Zn binding site [ion binding]; other site
355276003963	DJ-1 family protein; Region: not_thiJ; TIGR01383
355276003964	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
355276003965	conserved cys residue [active]
355276003966	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
355276003967	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
355276003968	active site
355276003969	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
355276003970	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
355276003971	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
355276003972	active site
355276003973	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
355276003974	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
355276003975	tandem repeat interface [polypeptide binding]; other site
355276003976	oligomer interface [polypeptide binding]; other site
355276003977	active site residues [active]
355276003978	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
355276003979	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
355276003980	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
355276003981	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
355276003982	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276003983	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
355276003984	active site
355276003985	Zn binding site [ion binding]; other site
355276003986	Integrase core domain; Region: rve_3; pfam13683
355276003987	Cell division protein FtsA; Region: FtsA; pfam14450
355276003988	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
355276003989	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
355276003990	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
355276003991	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
355276003992	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
355276003993	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
355276003994	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
355276003995	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
355276003996	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
355276003997	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
355276003998	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
355276003999	type II secretion system protein E; Region: type_II_gspE; TIGR02533
355276004000	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
355276004001	Walker A motif; other site
355276004002	ATP binding site [chemical binding]; other site
355276004003	Walker B motif; other site
355276004004	type II secretion system protein D; Region: type_II_gspD; TIGR02517
355276004005	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
355276004006	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
355276004007	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
355276004008	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
355276004009	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
355276004010	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
355276004011	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
355276004012	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276004013	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276004014	hypothetical protein; Reviewed; Region: PRK12497
355276004015	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
355276004016	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
355276004017	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276004018	Zn2+ binding site [ion binding]; other site
355276004019	Mg2+ binding site [ion binding]; other site
355276004020	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
355276004021	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
355276004022	RNA/DNA hybrid binding site [nucleotide binding]; other site
355276004023	active site
355276004024	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
355276004025	tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Provisional; Region: trmD; PRK14599
355276004026	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590
355276004027	RimM N-terminal domain; Region: RimM; pfam01782
355276004028	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
355276004029	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
355276004030	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
355276004031	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
355276004032	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
355276004033	substrate binding site [chemical binding]; other site
355276004034	hexamer interface [polypeptide binding]; other site
355276004035	metal binding site [ion binding]; metal-binding site
355276004036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
355276004037	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
355276004038	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
355276004039	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
355276004040	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
355276004041	putative active site [active]
355276004042	substrate binding site [chemical binding]; other site
355276004043	putative cosubstrate binding site; other site
355276004044	catalytic site [active]
355276004045	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
355276004046	substrate binding site [chemical binding]; other site
355276004047	primosome assembly protein PriA; Validated; Region: PRK05580
355276004048	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276004049	ATP binding site [chemical binding]; other site
355276004050	putative Mg++ binding site [ion binding]; other site
355276004051	helicase superfamily c-terminal domain; Region: HELICc; smart00490
355276004052	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
355276004053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004054	active site
355276004055	phosphorylation site [posttranslational modification]
355276004056	intermolecular recognition site; other site
355276004057	dimerization interface [polypeptide binding]; other site
355276004058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276004059	Walker A motif; other site
355276004060	ATP binding site [chemical binding]; other site
355276004061	Walker B motif; other site
355276004062	arginine finger; other site
355276004063	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
355276004064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276004065	dimerization interface [polypeptide binding]; other site
355276004066	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276004067	dimer interface [polypeptide binding]; other site
355276004068	phosphorylation site [posttranslational modification]
355276004069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276004070	ATP binding site [chemical binding]; other site
355276004071	Mg2+ binding site [ion binding]; other site
355276004072	G-X-G motif; other site
355276004073	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
355276004074	regulatory protein interface [polypeptide binding]; other site
355276004075	active site
355276004076	regulatory phosphorylation site [posttranslational modification]; other site
355276004077	HPr kinase/phosphorylase; Provisional; Region: PRK05428
355276004078	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
355276004079	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
355276004080	Hpr binding site; other site
355276004081	active site
355276004082	homohexamer subunit interaction site [polypeptide binding]; other site
355276004083	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
355276004084	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
355276004085	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
355276004086	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
355276004087	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
355276004088	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
355276004089	Walker A/P-loop; other site
355276004090	ATP binding site [chemical binding]; other site
355276004091	Q-loop/lid; other site
355276004092	ABC transporter signature motif; other site
355276004093	Walker B; other site
355276004094	D-loop; other site
355276004095	H-loop/switch region; other site
355276004096	OstA-like protein; Region: OstA; cl00844
355276004097	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
355276004098	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
355276004099	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
355276004100	CTP synthetase; Validated; Region: pyrG; PRK05380
355276004101	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
355276004102	Catalytic site [active]
355276004103	active site
355276004104	UTP binding site [chemical binding]; other site
355276004105	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
355276004106	active site
355276004107	putative oxyanion hole; other site
355276004108	catalytic triad [active]
355276004109	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
355276004110	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
355276004111	active site
355276004112	nucleotide binding site [chemical binding]; other site
355276004113	HIGH motif; other site
355276004114	KMSKS motif; other site
355276004115	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
355276004116	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
355276004117	putative ribose interaction site [chemical binding]; other site
355276004118	putative ADP binding site [chemical binding]; other site
355276004119	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
355276004120	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
355276004121	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
355276004122	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
355276004123	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
355276004124	active site
355276004125	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
355276004126	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
355276004127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276004128	S-adenosylmethionine binding site [chemical binding]; other site
355276004129	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
355276004130	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
355276004131	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
355276004132	Walker A/P-loop; other site
355276004133	ATP binding site [chemical binding]; other site
355276004134	Q-loop/lid; other site
355276004135	ABC transporter signature motif; other site
355276004136	Walker B; other site
355276004137	D-loop; other site
355276004138	H-loop/switch region; other site
355276004139	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
355276004140	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
355276004141	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
355276004142	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
355276004143	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
355276004144	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
355276004145	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
355276004146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276004147	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276004148	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276004149	cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488
355276004150	Low-spin heme binding site [chemical binding]; other site
355276004151	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
355276004152	D-pathway; other site
355276004153	Putative water exit pathway; other site
355276004154	Binuclear center (active site) [active]
355276004155	K-pathway; other site
355276004156	Putative proton exit pathway; other site
355276004157	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
355276004158	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
355276004159	Cytochrome c; Region: Cytochrom_C; cl11414
355276004160	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
355276004161	4Fe-4S binding domain; Region: Fer4_5; pfam12801
355276004162	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
355276004163	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
355276004164	FixH; Region: FixH; pfam05751
355276004165	YtkA-like; Region: YtkA; pfam13115
355276004166	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
355276004167	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
355276004168	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
355276004169	metal-binding site [ion binding]
355276004170	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
355276004171	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
355276004172	motif II; other site
355276004173	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
355276004174	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
355276004175	Family description; Region: DsbD_2; pfam13386
355276004176	Protein of unknown function (DUF342); Region: DUF342; pfam03961
355276004177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
355276004178	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276004179	ATP binding site [chemical binding]; other site
355276004180	Mg2+ binding site [ion binding]; other site
355276004181	G-X-G motif; other site
355276004182	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
355276004183	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
355276004184	active site
355276004185	Int/Topo IB signature motif; other site
355276004186	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276004187	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
355276004188	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276004189	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
355276004190	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
355276004191	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
355276004192	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
355276004193	glycogen binding site [chemical binding]; other site
355276004194	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
355276004195	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
355276004196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276004197	binding surface
355276004198	TPR motif; other site
355276004199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276004200	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276004201	binding surface
355276004202	TPR motif; other site
355276004203	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
355276004204	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
355276004205	ligand binding site [chemical binding]; other site
355276004206	NAD binding site [chemical binding]; other site
355276004207	tetramer interface [polypeptide binding]; other site
355276004208	catalytic site [active]
355276004209	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
355276004210	L-serine binding site [chemical binding]; other site
355276004211	ACT domain interface; other site
355276004212	PilZ domain; Region: PilZ; cl01260
355276004213	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
355276004214	CoenzymeA binding site [chemical binding]; other site
355276004215	subunit interaction site [polypeptide binding]; other site
355276004216	PHB binding site; other site
355276004217	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
355276004218	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
355276004219	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
355276004220	catalytic site [active]
355276004221	Domain of unknown function (DUF309); Region: DUF309; pfam03745
355276004222	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
355276004223	active site
355276004224	catalytic tetrad [active]
355276004225	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
355276004226	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
355276004227	putative Iron-sulfur protein interface [polypeptide binding]; other site
355276004228	proximal heme binding site [chemical binding]; other site
355276004229	distal heme binding site [chemical binding]; other site
355276004230	putative dimer interface [polypeptide binding]; other site
355276004231	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
355276004232	L-aspartate oxidase; Provisional; Region: PRK06175
355276004233	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
355276004234	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
355276004235	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
355276004236	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
355276004237	GTP-binding protein LepA; Provisional; Region: PRK05433
355276004238	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
355276004239	G1 box; other site
355276004240	putative GEF interaction site [polypeptide binding]; other site
355276004241	GTP/Mg2+ binding site [chemical binding]; other site
355276004242	Switch I region; other site
355276004243	G2 box; other site
355276004244	G3 box; other site
355276004245	Switch II region; other site
355276004246	G4 box; other site
355276004247	G5 box; other site
355276004248	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
355276004249	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
355276004250	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
355276004251	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
355276004252	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276004253	anti sigma factor interaction site; other site
355276004254	regulatory phosphorylation site [posttranslational modification]; other site
355276004255	Spc7 kinetochore protein; Region: Spc7; pfam08317
355276004256	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
355276004257	putative active site [active]
355276004258	putative metal binding site [ion binding]; other site
355276004259	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276004260	active site
355276004261	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
355276004262	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
355276004263	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
355276004264	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
355276004265	dimer interface [polypeptide binding]; other site
355276004266	putative anticodon binding site; other site
355276004267	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
355276004268	motif 1; other site
355276004269	active site
355276004270	motif 2; other site
355276004271	motif 3; other site
355276004272	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
355276004273	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
355276004274	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
355276004275	thiamine phosphate binding site [chemical binding]; other site
355276004276	active site
355276004277	pyrophosphate binding site [ion binding]; other site
355276004278	RNA methyltransferase, RsmE family; Region: TIGR00046
355276004279	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
355276004280	inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314
355276004281	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
355276004282	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
355276004283	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
355276004284	active site
355276004285	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
355276004286	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
355276004287	O-Antigen ligase; Region: Wzy_C; pfam04932
355276004288	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
355276004289	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
355276004290	active site
355276004291	NTP binding site [chemical binding]; other site
355276004292	metal binding triad [ion binding]; metal-binding site
355276004293	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
355276004294	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
355276004295	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
355276004296	RNA/DNA hybrid binding site [nucleotide binding]; other site
355276004297	active site
355276004298	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
355276004299	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
355276004300	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
355276004301	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
355276004302	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276004303	NAD(P) binding site [chemical binding]; other site
355276004304	active site
355276004305	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
355276004306	FAD binding domain; Region: FAD_binding_4; pfam01565
355276004307	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
355276004308	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
355276004309	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
355276004310	Ligand binding site; other site
355276004311	Putative Catalytic site; other site
355276004312	DXD motif; other site
355276004313	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276004314	non-specific DNA binding site [nucleotide binding]; other site
355276004315	salt bridge; other site
355276004316	sequence-specific DNA binding site [nucleotide binding]; other site
355276004317	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
355276004318	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
355276004319	HlyD family secretion protein; Region: HlyD_3; pfam13437
355276004320	Outer membrane efflux protein; Region: OEP; pfam02321
355276004321	Outer membrane efflux protein; Region: OEP; pfam02321
355276004322	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
355276004323	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
355276004324	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
355276004325	nucleotide binding region [chemical binding]; other site
355276004326	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
355276004327	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
355276004328	catalytic triad [active]
355276004329	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
355276004330	catalytic residues [active]
355276004331	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
355276004332	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
355276004333	Clp protease; Region: CLP_protease; pfam00574
355276004334	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
355276004335	oligomer interface [polypeptide binding]; other site
355276004336	active site residues [active]
355276004337	Septum formation initiator; Region: DivIC; pfam04977
355276004338	enolase; Provisional; Region: eno; PRK00077
355276004339	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
355276004340	dimer interface [polypeptide binding]; other site
355276004341	metal binding site [ion binding]; metal-binding site
355276004342	substrate binding pocket [chemical binding]; other site
355276004343	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
355276004344	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276004345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004346	active site
355276004347	phosphorylation site [posttranslational modification]
355276004348	intermolecular recognition site; other site
355276004349	dimerization interface [polypeptide binding]; other site
355276004350	HEAT repeats; Region: HEAT_2; pfam13646
355276004351	HEAT repeats; Region: HEAT_2; pfam13646
355276004352	HEAT repeats; Region: HEAT_2; pfam13646
355276004353	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276004354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276004355	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276004356	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276004357	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
355276004358	Bifunctional nuclease; Region: DNase-RNase; pfam02577
355276004359	UvrB/uvrC motif; Region: UVR; pfam02151
355276004360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276004361	Major Facilitator Superfamily; Region: MFS_1; pfam07690
355276004362	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
355276004363	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
355276004364	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276004365	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276004366	active site
355276004367	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
355276004368	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276004369	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276004370	ligand binding site [chemical binding]; other site
355276004371	flexible hinge region; other site
355276004372	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276004373	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276004374	ligand binding site [chemical binding]; other site
355276004375	flexible hinge region; other site
355276004376	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
355276004377	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
355276004378	catalytic residues [active]
355276004379	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
355276004380	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
355276004381	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276004382	Bacterial transcriptional activator domain; Region: BTAD; smart01043
355276004383	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
355276004384	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
355276004385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
355276004386	MORN repeat; Region: MORN; cl14787
355276004387	MORN repeat; Region: MORN; cl14787
355276004388	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
355276004389	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
355276004390	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
355276004391	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
355276004392	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
355276004393	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
355276004394	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
355276004395	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
355276004396	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
355276004397	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
355276004398	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
355276004399	tetramer interface [polypeptide binding]; other site
355276004400	heme binding pocket [chemical binding]; other site
355276004401	NADPH binding site [chemical binding]; other site
355276004402	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276004403	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276004404	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
355276004405	metal binding site 2 [ion binding]; metal-binding site
355276004406	putative DNA binding helix; other site
355276004407	metal binding site 1 [ion binding]; metal-binding site
355276004408	dimer interface [polypeptide binding]; other site
355276004409	structural Zn2+ binding site [ion binding]; other site
355276004410	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
355276004411	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
355276004412	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
355276004413	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
355276004414	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
355276004415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276004416	S-adenosylmethionine binding site [chemical binding]; other site
355276004417	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276004418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004419	active site
355276004420	phosphorylation site [posttranslational modification]
355276004421	intermolecular recognition site; other site
355276004422	dimerization interface [polypeptide binding]; other site
355276004423	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004424	PAS domain; Region: PAS_9; pfam13426
355276004425	putative active site [active]
355276004426	heme pocket [chemical binding]; other site
355276004427	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276004428	cyclase homology domain; Region: CHD; cd07302
355276004429	nucleotidyl binding site; other site
355276004430	metal binding site [ion binding]; metal-binding site
355276004431	dimer interface [polypeptide binding]; other site
355276004432	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
355276004433	Clp amino terminal domain; Region: Clp_N; pfam02861
355276004434	Clp amino terminal domain; Region: Clp_N; pfam02861
355276004435	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276004436	Walker A motif; other site
355276004437	ATP binding site [chemical binding]; other site
355276004438	Walker B motif; other site
355276004439	arginine finger; other site
355276004440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276004441	Walker A motif; other site
355276004442	ATP binding site [chemical binding]; other site
355276004443	Walker B motif; other site
355276004444	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
355276004445	Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333
355276004446	Na2 binding site [ion binding]; other site
355276004447	substrate binding site 1 [chemical binding]; other site
355276004448	Na binding site 1 [ion binding]; other site
355276004449	substrate binding site 2 [chemical binding]; other site
355276004450	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
355276004451	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
355276004452	DEAD_2; Region: DEAD_2; pfam06733
355276004453	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
355276004454	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
355276004455	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
355276004456	catalytic site [active]
355276004457	G-X2-G-X-G-K; other site
355276004458	hypothetical protein; Provisional; Region: PRK04323
355276004459	Protein of unknown function (DUF342); Region: DUF342; pfam03961
355276004460	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
355276004461	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276004462	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276004463	DNA binding residues [nucleotide binding]
355276004464	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
355276004465	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
355276004466	P-loop; other site
355276004467	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724
355276004468	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
355276004469	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
355276004470	FHIPEP family; Region: FHIPEP; pfam00771
355276004471	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
355276004472	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
355276004473	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
355276004474	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
355276004475	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
355276004476	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
355276004477	flagellar motor switch protein; Validated; Region: PRK08119
355276004478	flagellar motor switch protein FliN; Region: fliN; TIGR02480
355276004479	Protein of unknown function (DUF971); Region: DUF971; pfam06155
355276004480	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
355276004481	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
355276004482	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
355276004483	Head domain of virus receptor-binding proteins (RBP); Region: RBP-H; cl07506
355276004484	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
355276004485	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276004486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004487	putative active site [active]
355276004488	heme pocket [chemical binding]; other site
355276004489	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276004490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
355276004491	classical (c) SDRs; Region: SDR_c; cd05233
355276004492	short chain dehydrogenase; Provisional; Region: PRK06181
355276004493	NAD(P) binding site [chemical binding]; other site
355276004494	active site
355276004495	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
355276004496	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
355276004497	C-terminal domain interface [polypeptide binding]; other site
355276004498	GSH binding site (G-site) [chemical binding]; other site
355276004499	dimer interface [polypeptide binding]; other site
355276004500	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
355276004501	putative N-terminal domain interface [polypeptide binding]; other site
355276004502	putative dimer interface [polypeptide binding]; other site
355276004503	putative substrate binding pocket (H-site) [chemical binding]; other site
355276004504	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
355276004505	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
355276004506	active site
355276004507	Zn binding site [ion binding]; other site
355276004508	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
355276004509	putative active site [active]
355276004510	putative catalytic site [active]
355276004511	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
355276004512	active site 2 [active]
355276004513	active site 1 [active]
355276004514	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276004515	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
355276004516	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
355276004517	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
355276004518	PYR/PP interface [polypeptide binding]; other site
355276004519	dimer interface [polypeptide binding]; other site
355276004520	TPP binding site [chemical binding]; other site
355276004521	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
355276004522	S-adenosylmethionine synthetase; Validated; Region: PRK05250
355276004523	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
355276004524	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
355276004525	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
355276004526	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
355276004527	ParB-like nuclease domain; Region: ParBc; pfam02195
355276004528	Surface lipoprotein of Spirochaetales order; Region: Lipl32; pfam12103
355276004529	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276004530	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276004531	active site
355276004532	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
355276004533	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
355276004534	putative dimer interface [polypeptide binding]; other site
355276004535	putative anticodon binding site; other site
355276004536	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
355276004537	homodimer interface [polypeptide binding]; other site
355276004538	motif 1; other site
355276004539	motif 2; other site
355276004540	active site
355276004541	motif 3; other site
355276004542	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14177
355276004543	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
355276004544	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
355276004545	homodimer interface [polypeptide binding]; other site
355276004546	NADP binding site [chemical binding]; other site
355276004547	substrate binding site [chemical binding]; other site
355276004548	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
355276004549	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
355276004550	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
355276004551	active site
355276004552	HIGH motif; other site
355276004553	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
355276004554	KMSKS motif; other site
355276004555	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
355276004556	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
355276004557	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
355276004558	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
355276004559	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
355276004560	PGAP1-like protein; Region: PGAP1; pfam07819
355276004561	PGAP1-like protein; Region: PGAP1; pfam07819
355276004562	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
355276004563	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
355276004564	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
355276004565	substrate binding site [chemical binding]; other site
355276004566	glutamase interaction surface [polypeptide binding]; other site
355276004567	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
355276004568	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
355276004569	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
355276004570	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
355276004571	Bacterial sugar transferase; Region: Bac_transf; pfam02397
355276004572	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
355276004573	Bacitracin resistance protein BacA; Region: BacA; pfam02673
355276004574	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
355276004575	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
355276004576	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276004577	ATP binding site [chemical binding]; other site
355276004578	putative Mg++ binding site [ion binding]; other site
355276004579	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276004580	nucleotide binding region [chemical binding]; other site
355276004581	ATP-binding site [chemical binding]; other site
355276004582	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
355276004583	Pantoate-beta-alanine ligase; Region: PanC; cd00560
355276004584	pantoate--beta-alanine ligase; Region: panC; TIGR00018
355276004585	active site
355276004586	ATP-binding site [chemical binding]; other site
355276004587	pantoate-binding site; other site
355276004588	HXXH motif; other site
355276004589	histidinol dehydrogenase; Region: hisD; TIGR00069
355276004590	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
355276004591	NAD binding site [chemical binding]; other site
355276004592	dimerization interface [polypeptide binding]; other site
355276004593	product binding site; other site
355276004594	substrate binding site [chemical binding]; other site
355276004595	zinc binding site [ion binding]; other site
355276004596	catalytic residues [active]
355276004597	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
355276004598	putative active site [active]
355276004599	putative catalytic site [active]
355276004600	putative DNA binding site [nucleotide binding]; other site
355276004601	putative phosphate binding site [ion binding]; other site
355276004602	metal binding site A [ion binding]; metal-binding site
355276004603	putative AP binding site [nucleotide binding]; other site
355276004604	putative metal binding site B [ion binding]; other site
355276004605	Response regulator receiver domain; Region: Response_reg; pfam00072
355276004606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004607	active site
355276004608	phosphorylation site [posttranslational modification]
355276004609	intermolecular recognition site; other site
355276004610	dimerization interface [polypeptide binding]; other site
355276004611	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
355276004612	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
355276004613	metal binding site [ion binding]; metal-binding site
355276004614	active site
355276004615	I-site; other site
355276004616	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
355276004617	dimerization interface [polypeptide binding]; other site
355276004618	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
355276004619	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276004620	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276004621	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276004622	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
355276004623	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
355276004624	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
355276004625	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276004626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276004627	dimer interface [polypeptide binding]; other site
355276004628	phosphorylation site [posttranslational modification]
355276004629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276004630	ATP binding site [chemical binding]; other site
355276004631	Mg2+ binding site [ion binding]; other site
355276004632	G-X-G motif; other site
355276004633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004634	PAS domain; Region: PAS_9; pfam13426
355276004635	putative active site [active]
355276004636	heme pocket [chemical binding]; other site
355276004637	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276004638	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276004639	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276004640	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276004641	ligand binding site [chemical binding]; other site
355276004642	flexible hinge region; other site
355276004643	PAS domain; Region: PAS_9; pfam13426
355276004644	PAS domain S-box; Region: sensory_box; TIGR00229
355276004645	PAS domain; Region: PAS_9; pfam13426
355276004646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276004647	dimer interface [polypeptide binding]; other site
355276004648	phosphorylation site [posttranslational modification]
355276004649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276004650	ATP binding site [chemical binding]; other site
355276004651	Mg2+ binding site [ion binding]; other site
355276004652	G-X-G motif; other site
355276004653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004654	phosphorylation site [posttranslational modification]
355276004655	intermolecular recognition site; other site
355276004656	Response regulator receiver domain; Region: Response_reg; pfam00072
355276004657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004658	active site
355276004659	phosphorylation site [posttranslational modification]
355276004660	intermolecular recognition site; other site
355276004661	dimerization interface [polypeptide binding]; other site
355276004662	PAS domain S-box; Region: sensory_box; TIGR00229
355276004663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004664	putative active site [active]
355276004665	heme pocket [chemical binding]; other site
355276004666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
355276004667	PAS fold; Region: PAS_4; pfam08448
355276004668	putative active site [active]
355276004669	heme pocket [chemical binding]; other site
355276004670	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
355276004671	Histidine kinase; Region: HisKA_2; pfam07568
355276004672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276004673	ATP binding site [chemical binding]; other site
355276004674	Mg2+ binding site [ion binding]; other site
355276004675	G-X-G motif; other site
355276004676	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
355276004677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276004678	Walker A/P-loop; other site
355276004679	ATP binding site [chemical binding]; other site
355276004680	Q-loop/lid; other site
355276004681	ABC transporter signature motif; other site
355276004682	Walker B; other site
355276004683	D-loop; other site
355276004684	H-loop/switch region; other site
355276004685	ABC transporter; Region: ABC_tran_2; pfam12848
355276004686	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
355276004687	FecR protein; Region: FecR; pfam04773
355276004688	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276004689	dimerization interface [polypeptide binding]; other site
355276004690	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276004691	cyclase homology domain; Region: CHD; cd07302
355276004692	nucleotidyl binding site; other site
355276004693	metal binding site [ion binding]; metal-binding site
355276004694	dimer interface [polypeptide binding]; other site
355276004695	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
355276004696	active site
355276004697	Response regulator receiver domain; Region: Response_reg; pfam00072
355276004698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004699	active site
355276004700	phosphorylation site [posttranslational modification]
355276004701	intermolecular recognition site; other site
355276004702	dimerization interface [polypeptide binding]; other site
355276004703	PAS fold; Region: PAS; pfam00989
355276004704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004705	putative active site [active]
355276004706	heme pocket [chemical binding]; other site
355276004707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276004708	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276004709	dimer interface [polypeptide binding]; other site
355276004710	phosphorylation site [posttranslational modification]
355276004711	FOG: CBS domain [General function prediction only]; Region: COG0517
355276004712	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
355276004713	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
355276004714	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
355276004715	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
355276004716	Substrate binding site; other site
355276004717	Cupin domain; Region: Cupin_2; cl17218
355276004718	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
355276004719	bacterial Hfq-like; Region: Hfq; cd01716
355276004720	hexamer interface [polypeptide binding]; other site
355276004721	Sm1 motif; other site
355276004722	RNA binding site [nucleotide binding]; other site
355276004723	Sm2 motif; other site
355276004724	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
355276004725	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
355276004726	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
355276004727	TIGR02300 family protein; Region: FYDLN_acid
355276004728	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
355276004729	active site
355276004730	hydrophilic channel; other site
355276004731	dimerization interface [polypeptide binding]; other site
355276004732	catalytic residues [active]
355276004733	active site lid [active]
355276004734	C-terminal peptidase (prc); Region: prc; TIGR00225
355276004735	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
355276004736	protein binding site [polypeptide binding]; other site
355276004737	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
355276004738	Catalytic dyad [active]
355276004739	L-aspartate oxidase; Provisional; Region: PRK09077
355276004740	L-aspartate oxidase; Provisional; Region: PRK06175
355276004741	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
355276004742	Surface antigen; Region: Bac_surface_Ag; pfam01103
355276004743	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
355276004744	Surface antigen; Region: Bac_surface_Ag; pfam01103
355276004745	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
355276004746	carboxyltransferase (CT) interaction site; other site
355276004747	biotinylation site [posttranslational modification]; other site
355276004748	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
355276004749	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
355276004750	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276004751	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
355276004752	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
355276004753	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
355276004754	putative acyl-acceptor binding pocket; other site
355276004755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
355276004756	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
355276004757	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
355276004758	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
355276004759	dimerization interface 3.5A [polypeptide binding]; other site
355276004760	active site
355276004761	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
355276004762	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
355276004763	FMN binding site [chemical binding]; other site
355276004764	substrate binding site [chemical binding]; other site
355276004765	putative catalytic residue [active]
355276004766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276004767	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276004768	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276004769	Predicted transcriptional regulator [Transcription]; Region: COG1959
355276004770	Transcriptional regulator; Region: Rrf2; pfam02082
355276004771	Transcriptional regulator; Region: Rrf2; cl17282
355276004772	Domain of unknown function (DU1801); Region: DUF1801; cl17490
355276004773	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276004774	MepB protein; Region: MepB; cl01985
355276004775	Protein of unknown function (DUF445); Region: DUF445; pfam04286
355276004776	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
355276004777	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
355276004778	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
355276004779	substrate binding pocket [chemical binding]; other site
355276004780	membrane-bound complex binding site; other site
355276004781	hinge residues; other site
355276004782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276004783	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276004784	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276004785	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
355276004786	active site
355276004787	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
355276004788	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
355276004789	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
355276004790	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
355276004791	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
355276004792	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
355276004793	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
355276004794	rod shape-determining protein MreC; Provisional; Region: PRK13922
355276004795	rod shape-determining protein MreC; Region: MreC; pfam04085
355276004796	rod shape-determining protein MreB; Provisional; Region: PRK13927
355276004797	MreB and similar proteins; Region: MreB_like; cd10225
355276004798	nucleotide binding site [chemical binding]; other site
355276004799	Mg binding site [ion binding]; other site
355276004800	putative protofilament interaction site [polypeptide binding]; other site
355276004801	RodZ interaction site [polypeptide binding]; other site
355276004802	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
355276004803	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
355276004804	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
355276004805	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
355276004806	A new structural DNA glycosylase; Region: AlkD_like; cd06561
355276004807	active site
355276004808	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276004809	GAF domain; Region: GAF_3; pfam13492
355276004810	GAF domain; Region: GAF_2; pfam13185
355276004811	GAF domain; Region: GAF; cl17456
355276004812	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
355276004813	SLBB domain; Region: SLBB; pfam10531
355276004814	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444
355276004815	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
355276004816	gamma subunit interface [polypeptide binding]; other site
355276004817	epsilon subunit interface [polypeptide binding]; other site
355276004818	LBP interface [polypeptide binding]; other site
355276004819	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
355276004820	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
355276004821	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
355276004822	alpha subunit interaction interface [polypeptide binding]; other site
355276004823	Walker A motif; other site
355276004824	ATP binding site [chemical binding]; other site
355276004825	Walker B motif; other site
355276004826	inhibitor binding site; inhibition site
355276004827	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
355276004828	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
355276004829	core domain interface [polypeptide binding]; other site
355276004830	delta subunit interface [polypeptide binding]; other site
355276004831	epsilon subunit interface [polypeptide binding]; other site
355276004832	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
355276004833	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
355276004834	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
355276004835	beta subunit interaction interface [polypeptide binding]; other site
355276004836	Walker A motif; other site
355276004837	ATP binding site [chemical binding]; other site
355276004838	Walker B motif; other site
355276004839	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
355276004840	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13434
355276004841	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
355276004842	F0F1 ATP synthase subunit B; Provisional; Region: PRK13460
355276004843	F0F1 ATP synthase subunit A; Provisional; Region: PRK13417
355276004844	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
355276004845	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
355276004846	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
355276004847	Catalytic site [active]
355276004848	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
355276004849	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
355276004850	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276004851	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276004852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276004853	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276004854	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276004855	glutamine synthetase, type I; Region: GlnA; TIGR00653
355276004856	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
355276004857	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
355276004858	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
355276004859	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
355276004860	Walker A/P-loop; other site
355276004861	ATP binding site [chemical binding]; other site
355276004862	Q-loop/lid; other site
355276004863	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
355276004864	ABC transporter signature motif; other site
355276004865	Walker B; other site
355276004866	D-loop; other site
355276004867	H-loop/switch region; other site
355276004868	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
355276004869	membrane protein; Provisional; Region: PRK14409
355276004870	GTP-binding protein Der; Reviewed; Region: PRK00093
355276004871	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
355276004872	G1 box; other site
355276004873	GTP/Mg2+ binding site [chemical binding]; other site
355276004874	Switch I region; other site
355276004875	G2 box; other site
355276004876	Switch II region; other site
355276004877	G3 box; other site
355276004878	G4 box; other site
355276004879	G5 box; other site
355276004880	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
355276004881	G1 box; other site
355276004882	GTP/Mg2+ binding site [chemical binding]; other site
355276004883	Switch I region; other site
355276004884	G2 box; other site
355276004885	G3 box; other site
355276004886	Switch II region; other site
355276004887	G4 box; other site
355276004888	G5 box; other site
355276004889	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
355276004890	SmpB-tmRNA interface; other site
355276004891	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
355276004892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
355276004893	aspartate aminotransferase; Provisional; Region: PRK05764
355276004894	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276004895	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276004896	homodimer interface [polypeptide binding]; other site
355276004897	catalytic residue [active]
355276004898	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
355276004899	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
355276004900	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
355276004901	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
355276004902	Walker A/P-loop; other site
355276004903	ATP binding site [chemical binding]; other site
355276004904	Q-loop/lid; other site
355276004905	ABC transporter signature motif; other site
355276004906	Walker B; other site
355276004907	D-loop; other site
355276004908	H-loop/switch region; other site
355276004909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276004910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276004911	Sulfatase; Region: Sulfatase; pfam00884
355276004912	proline aminopeptidase P II; Provisional; Region: PRK10879
355276004913	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
355276004914	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
355276004915	active site
355276004916	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
355276004917	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
355276004918	putative active site [active]
355276004919	acetyl-CoA acetyltransferase; Provisional; Region: PRK06365
355276004920	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
355276004921	active site
355276004922	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
355276004923	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
355276004924	heme binding site [chemical binding]; other site
355276004925	ferroxidase pore; other site
355276004926	ferroxidase diiron center [ion binding]; other site
355276004927	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
355276004928	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
355276004929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
355276004930	acetylglutamate kinase; Provisional; Region: PRK04531
355276004931	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
355276004932	nucleotide binding site [chemical binding]; other site
355276004933	Protein of unknown function (DUF619); Region: DUF619; pfam04768
355276004934	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
355276004935	FeS assembly protein SufB; Region: sufB; TIGR01980
355276004936	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
355276004937	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
355276004938	dimer interface [polypeptide binding]; other site
355276004939	decamer (pentamer of dimers) interface [polypeptide binding]; other site
355276004940	catalytic triad [active]
355276004941	peroxidatic and resolving cysteines [active]
355276004942	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
355276004943	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276004944	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276004945	dimer interface [polypeptide binding]; other site
355276004946	putative CheW interface [polypeptide binding]; other site
355276004947	YceI-like domain; Region: YceI; pfam04264
355276004948	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
355276004949	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
355276004950	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
355276004951	Ligand binding site; other site
355276004952	Putative Catalytic site; other site
355276004953	DXD motif; other site
355276004954	Predicted membrane protein [Function unknown]; Region: COG2246
355276004955	GtrA-like protein; Region: GtrA; pfam04138
355276004956	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
355276004957	CoenzymeA binding site [chemical binding]; other site
355276004958	subunit interaction site [polypeptide binding]; other site
355276004959	PHB binding site; other site
355276004960	Response regulator receiver domain; Region: Response_reg; pfam00072
355276004961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004962	active site
355276004963	phosphorylation site [posttranslational modification]
355276004964	intermolecular recognition site; other site
355276004965	dimerization interface [polypeptide binding]; other site
355276004966	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
355276004967	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276004968	dimer interface [polypeptide binding]; other site
355276004969	phosphorylation site [posttranslational modification]
355276004970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276004971	ATP binding site [chemical binding]; other site
355276004972	Mg2+ binding site [ion binding]; other site
355276004973	G-X-G motif; other site
355276004974	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276004975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276004976	active site
355276004977	phosphorylation site [posttranslational modification]
355276004978	intermolecular recognition site; other site
355276004979	dimerization interface [polypeptide binding]; other site
355276004980	PAS domain S-box; Region: sensory_box; TIGR00229
355276004981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004982	putative active site [active]
355276004983	heme pocket [chemical binding]; other site
355276004984	PAS fold; Region: PAS_4; pfam08448
355276004985	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004986	putative active site [active]
355276004987	heme pocket [chemical binding]; other site
355276004988	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276004989	GAF domain; Region: GAF; pfam01590
355276004990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276004991	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276004992	putative active site [active]
355276004993	heme pocket [chemical binding]; other site
355276004994	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276004995	dimer interface [polypeptide binding]; other site
355276004996	phosphorylation site [posttranslational modification]
355276004997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276004998	ATP binding site [chemical binding]; other site
355276004999	Mg2+ binding site [ion binding]; other site
355276005000	G-X-G motif; other site
355276005001	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
355276005002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005003	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005004	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005005	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
355276005006	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276005007	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276005008	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
355276005009	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
355276005010	RNA binding surface [nucleotide binding]; other site
355276005011	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
355276005012	active site
355276005013	PilZ domain; Region: PilZ; pfam07238
355276005014	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
355276005015	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
355276005016	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
355276005017	active site
355276005018	substrate binding site [chemical binding]; other site
355276005019	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
355276005020	FMN binding site [chemical binding]; other site
355276005021	putative catalytic residues [active]
355276005022	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
355276005023	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
355276005024	Ligand Binding Site [chemical binding]; other site
355276005025	Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303
355276005026	inhibitor binding site; inhibition site
355276005027	catalytic motif [active]
355276005028	Catalytic residue [active]
355276005029	Active site flap [active]
355276005030	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276005031	GAF domain; Region: GAF_3; pfam13492
355276005032	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
355276005033	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
355276005034	metal binding site [ion binding]; metal-binding site
355276005035	active site
355276005036	I-site; other site
355276005037	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
355276005038	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
355276005039	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
355276005040	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
355276005041	catalytic residue [active]
355276005042	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
355276005043	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
355276005044	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
355276005045	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
355276005046	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
355276005047	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
355276005048	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
355276005049	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
355276005050	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
355276005051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276005052	TPR motif; other site
355276005053	binding surface
355276005054	TRL-like protein family; Region: TRL; pfam13146
355276005055	TRL-like protein family; Region: TRL; pfam13146
355276005056	TRL-like protein family; Region: TRL; pfam13146
355276005057	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
355276005058	trehalose synthase; Region: treS_nterm; TIGR02456
355276005059	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
355276005060	Ca binding site [ion binding]; other site
355276005061	active site
355276005062	catalytic site [active]
355276005063	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
355276005064	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
355276005065	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
355276005066	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
355276005067	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
355276005068	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
355276005069	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
355276005070	NAD binding site [chemical binding]; other site
355276005071	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276005072	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
355276005073	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
355276005074	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
355276005075	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
355276005076	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
355276005077	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
355276005078	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
355276005079	Walker A/P-loop; other site
355276005080	ATP binding site [chemical binding]; other site
355276005081	Q-loop/lid; other site
355276005082	ABC transporter signature motif; other site
355276005083	Walker B; other site
355276005084	D-loop; other site
355276005085	H-loop/switch region; other site
355276005086	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
355276005087	putative carbohydrate binding site [chemical binding]; other site
355276005088	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
355276005089	hypothetical protein; Reviewed; Region: PRK00024
355276005090	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
355276005091	MPN+ (JAMM) motif; other site
355276005092	Zinc-binding site [ion binding]; other site
355276005093	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
355276005094	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
355276005095	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
355276005096	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
355276005097	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
355276005098	RNase E interface [polypeptide binding]; other site
355276005099	trimer interface [polypeptide binding]; other site
355276005100	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
355276005101	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
355276005102	RNase E interface [polypeptide binding]; other site
355276005103	trimer interface [polypeptide binding]; other site
355276005104	active site
355276005105	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
355276005106	putative nucleic acid binding region [nucleotide binding]; other site
355276005107	G-X-X-G motif; other site
355276005108	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
355276005109	RNA binding site [nucleotide binding]; other site
355276005110	domain interface; other site
355276005111	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
355276005112	16S/18S rRNA binding site [nucleotide binding]; other site
355276005113	S13e-L30e interaction site [polypeptide binding]; other site
355276005114	25S rRNA binding site [nucleotide binding]; other site
355276005115	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
355276005116	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
355276005117	active site
355276005118	Ribosome-binding factor A; Region: RBFA; pfam02033
355276005119	translation initiation factor IF-2; Region: IF-2; TIGR00487
355276005120	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
355276005121	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
355276005122	G1 box; other site
355276005123	putative GEF interaction site [polypeptide binding]; other site
355276005124	GTP/Mg2+ binding site [chemical binding]; other site
355276005125	Switch I region; other site
355276005126	G2 box; other site
355276005127	G3 box; other site
355276005128	Switch II region; other site
355276005129	G4 box; other site
355276005130	G5 box; other site
355276005131	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
355276005132	Translation-initiation factor 2; Region: IF-2; pfam11987
355276005133	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
355276005134	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
355276005135	NusA N-terminal domain; Region: NusA_N; pfam08529
355276005136	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
355276005137	RNA binding site [nucleotide binding]; other site
355276005138	homodimer interface [polypeptide binding]; other site
355276005139	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
355276005140	G-X-X-G motif; other site
355276005141	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
355276005142	G-X-X-G motif; other site
355276005143	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
355276005144	hypothetical protein; Provisional; Region: PRK14635
355276005145	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
355276005146	heptamer interface [polypeptide binding]; other site
355276005147	Sm1 motif; other site
355276005148	hexamer interface [polypeptide binding]; other site
355276005149	RNA binding site [nucleotide binding]; other site
355276005150	Sm2 motif; other site
355276005151	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
355276005152	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
355276005153	putative substrate binding site [chemical binding]; other site
355276005154	putative ATP binding site [chemical binding]; other site
355276005155	putative phosphate acyltransferase; Provisional; Region: PRK05331
355276005156	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
355276005157	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
355276005158	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
355276005159	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276005160	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
355276005161	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
355276005162	RNA binding site [nucleotide binding]; other site
355276005163	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
355276005164	RNA binding site [nucleotide binding]; other site
355276005165	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276005166	RNA binding site [nucleotide binding]; other site
355276005167	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276005168	RNA binding site [nucleotide binding]; other site
355276005169	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276005170	RNA binding site [nucleotide binding]; other site
355276005171	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
355276005172	RNA binding site [nucleotide binding]; other site
355276005173	cytidylate kinase; Provisional; Region: cmk; PRK00023
355276005174	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
355276005175	CMP-binding site; other site
355276005176	The sites determining sugar specificity; other site
355276005177	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
355276005178	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
355276005179	hinge; other site
355276005180	active site
355276005181	prephenate dehydrogenase; Validated; Region: PRK08507
355276005182	Chorismate mutase type II; Region: CM_2; pfam01817
355276005183	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
355276005184	Prephenate dehydratase; Region: PDT; pfam00800
355276005185	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
355276005186	putative L-Phe binding site [chemical binding]; other site
355276005187	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
355276005188	ScpA/B protein; Region: ScpA_ScpB; cl00598
355276005189	Response regulator receiver domain; Region: Response_reg; pfam00072
355276005190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276005191	active site
355276005192	phosphorylation site [posttranslational modification]
355276005193	intermolecular recognition site; other site
355276005194	dimerization interface [polypeptide binding]; other site
355276005195	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
355276005196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276005197	active site
355276005198	phosphorylation site [posttranslational modification]
355276005199	intermolecular recognition site; other site
355276005200	dimerization interface [polypeptide binding]; other site
355276005201	CheB methylesterase; Region: CheB_methylest; pfam01339
355276005202	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
355276005203	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
355276005204	putative binding surface; other site
355276005205	active site
355276005206	P2 response regulator binding domain; Region: P2; pfam07194
355276005207	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
355276005208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276005209	ATP binding site [chemical binding]; other site
355276005210	Mg2+ binding site [ion binding]; other site
355276005211	G-X-G motif; other site
355276005212	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
355276005213	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
355276005214	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
355276005215	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
355276005216	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
355276005217	Cell division protein ZapA; Region: ZapA; pfam05164
355276005218	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
355276005219	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
355276005220	23S rRNA binding site [nucleotide binding]; other site
355276005221	L21 binding site [polypeptide binding]; other site
355276005222	L13 binding site [polypeptide binding]; other site
355276005223	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
355276005224	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
355276005225	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
355276005226	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
355276005227	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005228	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005229	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005230	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
355276005231	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
355276005232	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
355276005233	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
355276005234	active site
355276005235	dimer interface [polypeptide binding]; other site
355276005236	motif 1; other site
355276005237	motif 2; other site
355276005238	motif 3; other site
355276005239	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
355276005240	anticodon binding site; other site
355276005241	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
355276005242	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
355276005243	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
355276005244	catalytic site [active]
355276005245	subunit interface [polypeptide binding]; other site
355276005246	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
355276005247	Fic family protein [Function unknown]; Region: COG3177
355276005248	Fic/DOC family; Region: Fic; pfam02661
355276005249	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
355276005250	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
355276005251	TPP-binding site [chemical binding]; other site
355276005252	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
355276005253	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
355276005254	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
355276005255	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
355276005256	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
355276005257	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
355276005258	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
355276005259	E3 interaction surface; other site
355276005260	lipoyl attachment site [posttranslational modification]; other site
355276005261	e3 binding domain; Region: E3_binding; pfam02817
355276005262	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
355276005263	Transglycosylase; Region: Transgly; pfam00912
355276005264	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
355276005265	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
355276005266	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
355276005267	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
355276005268	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
355276005269	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
355276005270	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
355276005271	dimer interface [polypeptide binding]; other site
355276005272	active site
355276005273	glycine-pyridoxal phosphate binding site [chemical binding]; other site
355276005274	folate binding site [chemical binding]; other site
355276005275	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
355276005276	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
355276005277	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
355276005278	HlyD family secretion protein; Region: HlyD_3; pfam13437
355276005279	Outer membrane efflux protein; Region: OEP; pfam02321
355276005280	Outer membrane efflux protein; Region: OEP; pfam02321
355276005281	Uncharacterized conserved protein [Function unknown]; Region: COG3268
355276005282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276005283	NAD(P) binding site [chemical binding]; other site
355276005284	Integrase core domain; Region: rve; pfam00665
355276005285	Integrase core domain; Region: rve_3; pfam13683
355276005286	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
355276005287	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
355276005288	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
355276005289	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
355276005290	Catalytic domain of Protein Kinases; Region: PKc; cd00180
355276005291	active site
355276005292	ATP binding site [chemical binding]; other site
355276005293	substrate binding site [chemical binding]; other site
355276005294	activation loop (A-loop); other site
355276005295	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
355276005296	AAA ATPase domain; Region: AAA_16; pfam13191
355276005297	Predicted ATPase [General function prediction only]; Region: COG3899
355276005298	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276005299	GAF domain; Region: GAF; pfam01590
355276005300	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276005301	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276005302	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
355276005303	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
355276005304	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
355276005305	Walker A/P-loop; other site
355276005306	ATP binding site [chemical binding]; other site
355276005307	Q-loop/lid; other site
355276005308	ABC transporter signature motif; other site
355276005309	Walker B; other site
355276005310	D-loop; other site
355276005311	H-loop/switch region; other site
355276005312	TOBE-like domain; Region: TOBE_3; pfam12857
355276005313	sulfate transport protein; Provisional; Region: cysT; CHL00187
355276005314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
355276005315	dimer interface [polypeptide binding]; other site
355276005316	conserved gate region; other site
355276005317	putative PBP binding loops; other site
355276005318	ABC-ATPase subunit interface; other site
355276005319	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
355276005320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
355276005321	dimer interface [polypeptide binding]; other site
355276005322	conserved gate region; other site
355276005323	putative PBP binding loops; other site
355276005324	ABC-ATPase subunit interface; other site
355276005325	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
355276005326	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
355276005327	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
355276005328	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
355276005329	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
355276005330	dimerization interface [polypeptide binding]; other site
355276005331	active site
355276005332	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
355276005333	Lumazine binding domain; Region: Lum_binding; pfam00677
355276005334	Lumazine binding domain; Region: Lum_binding; pfam00677
355276005335	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
355276005336	catalytic motif [active]
355276005337	Zn binding site [ion binding]; other site
355276005338	RibD C-terminal domain; Region: RibD_C; cl17279
355276005339	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
355276005340	Protein export membrane protein; Region: SecD_SecF; pfam02355
355276005341	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
355276005342	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
355276005343	Preprotein translocase subunit; Region: YajC; pfam02699
355276005344	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
355276005345	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
355276005346	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
355276005347	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
355276005348	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
355276005349	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
355276005350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276005351	FeS/SAM binding site; other site
355276005352	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
355276005353	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276005354	non-specific DNA binding site [nucleotide binding]; other site
355276005355	salt bridge; other site
355276005356	sequence-specific DNA binding site [nucleotide binding]; other site
355276005357	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
355276005358	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
355276005359	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
355276005360	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
355276005361	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
355276005362	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
355276005363	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
355276005364	Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375
355276005365	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276005366	Oligomerisation domain; Region: Oligomerisation; pfam02410
355276005367	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
355276005368	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
355276005369	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
355276005370	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
355276005371	dimer interface [polypeptide binding]; other site
355276005372	acyl-activating enzyme (AAE) consensus motif; other site
355276005373	putative active site [active]
355276005374	AMP binding site [chemical binding]; other site
355276005375	putative CoA binding site [chemical binding]; other site
355276005376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276005377	binding surface
355276005378	TPR motif; other site
355276005379	Restriction endonuclease; Region: Mrr_cat; pfam04471
355276005380	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
355276005381	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
355276005382	Walker A/P-loop; other site
355276005383	ATP binding site [chemical binding]; other site
355276005384	Q-loop/lid; other site
355276005385	ABC transporter signature motif; other site
355276005386	Walker B; other site
355276005387	D-loop; other site
355276005388	H-loop/switch region; other site
355276005389	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
355276005390	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
355276005391	nucleotide binding site [chemical binding]; other site
355276005392	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
355276005393	nucleotide binding site/active site [active]
355276005394	HIT family signature motif; other site
355276005395	catalytic residue [active]
355276005396	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
355276005397	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
355276005398	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276005399	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276005400	ATP binding site [chemical binding]; other site
355276005401	Mg2+ binding site [ion binding]; other site
355276005402	G-X-G motif; other site
355276005403	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276005404	cyclase homology domain; Region: CHD; cd07302
355276005405	nucleotidyl binding site; other site
355276005406	metal binding site [ion binding]; metal-binding site
355276005407	dimer interface [polypeptide binding]; other site
355276005408	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
355276005409	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
355276005410	dimer interface [polypeptide binding]; other site
355276005411	active site
355276005412	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
355276005413	Protein phosphatase 2C; Region: PP2C; pfam00481
355276005414	active site
355276005415	short chain dehydrogenase; Provisional; Region: PRK06172
355276005416	classical (c) SDRs; Region: SDR_c; cd05233
355276005417	NAD(P) binding site [chemical binding]; other site
355276005418	active site
355276005419	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
355276005420	active site
355276005421	Coenzyme A transferase; Region: CoA_trans; pfam01144
355276005422	Coenzyme A transferase; Region: CoA_trans; cl17247
355276005423	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
355276005424	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
355276005425	dimer interface [polypeptide binding]; other site
355276005426	active site
355276005427	CoA binding pocket [chemical binding]; other site
355276005428	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
355276005429	Catalytic domain of Protein Kinases; Region: PKc; cd00180
355276005430	active site
355276005431	ATP binding site [chemical binding]; other site
355276005432	substrate binding site [chemical binding]; other site
355276005433	activation loop (A-loop); other site
355276005434	AAA ATPase domain; Region: AAA_16; pfam13191
355276005435	Predicted ATPase [General function prediction only]; Region: COG3899
355276005436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276005437	binding surface
355276005438	TPR motif; other site
355276005439	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276005440	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
355276005441	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276005442	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
355276005443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276005444	GAF domain; Region: GAF_3; pfam13492
355276005445	Heme NO binding associated; Region: HNOBA; pfam07701
355276005446	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
355276005447	cyclase homology domain; Region: CHD; cd07302
355276005448	nucleotidyl binding site; other site
355276005449	metal binding site [ion binding]; metal-binding site
355276005450	dimer interface [polypeptide binding]; other site
355276005451	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
355276005452	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
355276005453	dimer interface [polypeptide binding]; other site
355276005454	substrate binding site [chemical binding]; other site
355276005455	metal binding site [ion binding]; metal-binding site
355276005456	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
355276005457	putative catalytic site [active]
355276005458	putative metal binding site [ion binding]; other site
355276005459	putative phosphate binding site [ion binding]; other site
355276005460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005461	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005462	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005463	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
355276005464	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
355276005465	putative active site [active]
355276005466	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276005467	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
355276005468	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
355276005469	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
355276005470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
355276005471	motif II; other site
355276005472	TPR repeat; Region: TPR_11; pfam13414
355276005473	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
355276005474	PilZ domain; Region: PilZ; pfam07238
355276005475	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
355276005476	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276005477	substrate binding site [chemical binding]; other site
355276005478	oxyanion hole (OAH) forming residues; other site
355276005479	trimer interface [polypeptide binding]; other site
355276005480	Putative glycosyl hydrolase domain; Region: DUF4015; cl17870
355276005481	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
355276005482	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
355276005483	active site
355276005484	Zn binding site [ion binding]; other site
355276005485	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276005486	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
355276005487	30S subunit binding site; other site
355276005488	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
355276005489	binding surface
355276005490	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276005491	TPR motif; other site
355276005492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005493	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005494	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005495	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
355276005496	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276005497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276005498	homodimer interface [polypeptide binding]; other site
355276005499	catalytic residue [active]
355276005500	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005501	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005502	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005503	recombination factor protein RarA; Reviewed; Region: PRK13342
355276005504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276005505	Walker A motif; other site
355276005506	ATP binding site [chemical binding]; other site
355276005507	Walker B motif; other site
355276005508	arginine finger; other site
355276005509	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
355276005510	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276005511	Leucine rich repeat; Region: LRR_8; pfam13855
355276005512	Predicted membrane protein [Function unknown]; Region: COG1238
355276005513	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
355276005514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276005515	ATP binding site [chemical binding]; other site
355276005516	Mg2+ binding site [ion binding]; other site
355276005517	G-X-G motif; other site
355276005518	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
355276005519	ATP binding site [chemical binding]; other site
355276005520	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
355276005521	Protein of unknown function (DUF1554); Region: DUF1554; pfam07588
355276005522	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
355276005523	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
355276005524	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
355276005525	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
355276005526	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
355276005527	substrate binding site [chemical binding]; other site
355276005528	ATP binding site [chemical binding]; other site
355276005529	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
355276005530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276005531	S-adenosylmethionine binding site [chemical binding]; other site
355276005532	Protease prsW family; Region: PrsW-protease; pfam13367
355276005533	Gram-negative bacterial tonB protein; Region: TonB; cl10048
355276005534	glycyl-tRNA synthetase; Provisional; Region: PRK04173
355276005535	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
355276005536	motif 1; other site
355276005537	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
355276005538	active site
355276005539	motif 2; other site
355276005540	motif 3; other site
355276005541	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
355276005542	anticodon binding site; other site
355276005543	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
355276005544	trimer interface [polypeptide binding]; other site
355276005545	active site
355276005546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005547	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005548	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005549	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
355276005550	hydrophobic ligand binding site; other site
355276005551	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
355276005552	dimerization interface [polypeptide binding]; other site
355276005553	putative DNA binding site [nucleotide binding]; other site
355276005554	putative Zn2+ binding site [ion binding]; other site
355276005555	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
355276005556	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
355276005557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276005558	NAD(P) binding site [chemical binding]; other site
355276005559	active site
355276005560	adenylosuccinate lyase; Provisional; Region: PRK07492
355276005561	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
355276005562	tetramer interface [polypeptide binding]; other site
355276005563	active site
355276005564	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
355276005565	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
355276005566	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
355276005567	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
355276005568	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276005569	Zn2+ binding site [ion binding]; other site
355276005570	Mg2+ binding site [ion binding]; other site
355276005571	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
355276005572	synthetase active site [active]
355276005573	NTP binding site [chemical binding]; other site
355276005574	metal binding site [ion binding]; metal-binding site
355276005575	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
355276005576	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
355276005577	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
355276005578	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
355276005579	dimerization interface [polypeptide binding]; other site
355276005580	active site
355276005581	Domain of unknown function (DUF4398); Region: DUF4398; pfam14346
355276005582	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
355276005583	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276005584	anti sigma factor interaction site; other site
355276005585	regulatory phosphorylation site [posttranslational modification]; other site
355276005586	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
355276005587	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
355276005588	ferric uptake regulator; Provisional; Region: fur; PRK09462
355276005589	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
355276005590	metal binding site 2 [ion binding]; metal-binding site
355276005591	putative DNA binding helix; other site
355276005592	metal binding site 1 [ion binding]; metal-binding site
355276005593	dimer interface [polypeptide binding]; other site
355276005594	structural Zn2+ binding site [ion binding]; other site
355276005595	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276005596	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276005597	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
355276005598	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276005599	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
355276005600	four helix bundle protein; Region: TIGR02436
355276005601	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
355276005602	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
355276005603	active site
355276005604	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
355276005605	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
355276005606	catalytic triad [active]
355276005607	multifunctional aminopeptidase A; Provisional; Region: PRK00913
355276005608	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
355276005609	interface (dimer of trimers) [polypeptide binding]; other site
355276005610	Substrate-binding/catalytic site; other site
355276005611	Zn-binding sites [ion binding]; other site
355276005612	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
355276005613	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
355276005614	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
355276005615	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
355276005616	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
355276005617	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
355276005618	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
355276005619	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
355276005620	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
355276005621	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
355276005622	The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764
355276005623	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
355276005624	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
355276005625	4Fe-4S binding domain; Region: Fer4_2; pfam12797
355276005626	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
355276005627	heme-binding residues [chemical binding]; other site
355276005628	Integrase core domain; Region: rve; pfam00665
355276005629	Integrase core domain; Region: rve_3; pfam13683
355276005630	Integrase core domain; Region: rve; pfam00665
355276005631	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
355276005632	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
355276005633	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14465
355276005634	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276005635	FeS/SAM binding site; other site
355276005636	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
355276005637	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
355276005638	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
355276005639	active site
355276005640	ribulose/triose binding site [chemical binding]; other site
355276005641	phosphate binding site [ion binding]; other site
355276005642	substrate (anthranilate) binding pocket [chemical binding]; other site
355276005643	product (indole) binding pocket [chemical binding]; other site
355276005644	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276005645	anti sigma factor interaction site; other site
355276005646	regulatory phosphorylation site [posttranslational modification]; other site
355276005647	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
355276005648	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
355276005649	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
355276005650	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276005651	GAF domain; Region: GAF; pfam01590
355276005652	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276005653	Zn2+ binding site [ion binding]; other site
355276005654	Mg2+ binding site [ion binding]; other site
355276005655	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276005656	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
355276005657	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
355276005658	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
355276005659	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
355276005660	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
355276005661	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
355276005662	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
355276005663	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
355276005664	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
355276005665	putative catalytic residue [active]
355276005666	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276005667	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
355276005668	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
355276005669	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
355276005670	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
355276005671	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
355276005672	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276005673	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
355276005674	IMP binding site; other site
355276005675	dimer interface [polypeptide binding]; other site
355276005676	interdomain contacts; other site
355276005677	partial ornithine binding site; other site
355276005678	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
355276005679	Sulfatase; Region: Sulfatase; pfam00884
355276005680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
355276005681	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
355276005682	transcriptional regulator NarP; Provisional; Region: PRK10403
355276005683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276005684	active site
355276005685	phosphorylation site [posttranslational modification]
355276005686	intermolecular recognition site; other site
355276005687	dimerization interface [polypeptide binding]; other site
355276005688	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
355276005689	DNA binding residues [nucleotide binding]
355276005690	dimerization interface [polypeptide binding]; other site
355276005691	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276005692	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276005693	Histidine kinase; Region: HisKA_3; pfam07730
355276005694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276005695	ATP binding site [chemical binding]; other site
355276005696	Mg2+ binding site [ion binding]; other site
355276005697	G-X-G motif; other site
355276005698	PIN domain; Region: PIN; pfam01850
355276005699	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
355276005700	Gram-negative bacterial tonB protein; Region: TonB; cl10048
355276005701	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
355276005702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276005703	Walker A motif; other site
355276005704	ATP binding site [chemical binding]; other site
355276005705	Walker B motif; other site
355276005706	arginine finger; other site
355276005707	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
355276005708	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
355276005709	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
355276005710	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
355276005711	protein binding site [polypeptide binding]; other site
355276005712	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
355276005713	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
355276005714	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
355276005715	TMP-binding site; other site
355276005716	ATP-binding site [chemical binding]; other site
355276005717	TPR repeat; Region: TPR_11; pfam13414
355276005718	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276005719	binding surface
355276005720	TPR motif; other site
355276005721	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276005722	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
355276005723	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
355276005724	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
355276005725	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
355276005726	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
355276005727	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
355276005728	N-acetyl-D-glucosamine binding site [chemical binding]; other site
355276005729	catalytic residue [active]
355276005730	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
355276005731	dimer interface [polypeptide binding]; other site
355276005732	Citrate synthase; Region: Citrate_synt; pfam00285
355276005733	active site
355276005734	citrylCoA binding site [chemical binding]; other site
355276005735	NADH binding [chemical binding]; other site
355276005736	cationic pore residues; other site
355276005737	oxalacetate/citrate binding site [chemical binding]; other site
355276005738	coenzyme A binding site [chemical binding]; other site
355276005739	catalytic triad [active]
355276005740	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
355276005741	putative RNA binding site [nucleotide binding]; other site
355276005742	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
355276005743	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
355276005744	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
355276005745	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
355276005746	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
355276005747	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
355276005748	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
355276005749	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
355276005750	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
355276005751	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
355276005752	active site
355276005753	dimer interface [polypeptide binding]; other site
355276005754	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
355276005755	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
355276005756	active site
355276005757	FMN binding site [chemical binding]; other site
355276005758	substrate binding site [chemical binding]; other site
355276005759	3Fe-4S cluster binding site [ion binding]; other site
355276005760	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
355276005761	domain interface; other site
355276005762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276005763	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276005764	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276005765	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
355276005766	GcpE protein; Region: GcpE; pfam04551
355276005767	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
355276005768	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
355276005769	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
355276005770	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
355276005771	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
355276005772	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
355276005773	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
355276005774	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276005775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276005776	homodimer interface [polypeptide binding]; other site
355276005777	catalytic residue [active]
355276005778	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
355276005779	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
355276005780	transcription termination factor Rho; Provisional; Region: rho; PRK09376
355276005781	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
355276005782	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
355276005783	RNA binding site [nucleotide binding]; other site
355276005784	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
355276005785	multimer interface [polypeptide binding]; other site
355276005786	Walker A motif; other site
355276005787	ATP binding site [chemical binding]; other site
355276005788	Walker B motif; other site
355276005789	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
355276005790	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
355276005791	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
355276005792	trimerization site [polypeptide binding]; other site
355276005793	active site
355276005794	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
355276005795	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
355276005796	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
355276005797	FecR protein; Region: FecR; pfam04773
355276005798	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276005799	dimerization interface [polypeptide binding]; other site
355276005800	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276005801	cyclase homology domain; Region: CHD; cd07302
355276005802	nucleotidyl binding site; other site
355276005803	metal binding site [ion binding]; metal-binding site
355276005804	dimer interface [polypeptide binding]; other site
355276005805	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
355276005806	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
355276005807	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
355276005808	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
355276005809	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
355276005810	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
355276005811	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
355276005812	Mechanosensitive ion channel; Region: MS_channel; pfam00924
355276005813	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
355276005814	Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520
355276005815	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
355276005816	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
355276005817	ATP-grasp domain; Region: ATP-grasp_4; cl17255
355276005818	transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720
355276005819	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
355276005820	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
355276005821	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
355276005822	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
355276005823	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
355276005824	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
355276005825	putative active site [active]
355276005826	catalytic triad [active]
355276005827	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
355276005828	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
355276005829	active site
355276005830	ATP binding site [chemical binding]; other site
355276005831	substrate binding site [chemical binding]; other site
355276005832	Response regulator receiver domain; Region: Response_reg; pfam00072
355276005833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276005834	active site
355276005835	phosphorylation site [posttranslational modification]
355276005836	intermolecular recognition site; other site
355276005837	dimerization interface [polypeptide binding]; other site
355276005838	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276005839	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276005840	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
355276005841	CcmB protein; Region: CcmB; cl17444
355276005842	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
355276005843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276005844	Walker A/P-loop; other site
355276005845	ATP binding site [chemical binding]; other site
355276005846	Q-loop/lid; other site
355276005847	ABC transporter signature motif; other site
355276005848	Walker B; other site
355276005849	D-loop; other site
355276005850	H-loop/switch region; other site
355276005851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276005852	binding surface
355276005853	TPR motif; other site
355276005854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276005855	binding surface
355276005856	TPR motif; other site
355276005857	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
355276005858	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
355276005859	Walker A/P-loop; other site
355276005860	ATP binding site [chemical binding]; other site
355276005861	Q-loop/lid; other site
355276005862	ABC transporter signature motif; other site
355276005863	Walker B; other site
355276005864	D-loop; other site
355276005865	H-loop/switch region; other site
355276005866	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
355276005867	dimerization interface [polypeptide binding]; other site
355276005868	putative DNA binding site [nucleotide binding]; other site
355276005869	putative Zn2+ binding site [ion binding]; other site
355276005870	DoxX-like family; Region: DoxX_2; pfam13564
355276005871	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
355276005872	hydrophobic ligand binding site; other site
355276005873	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
355276005874	putative hydrophobic ligand binding site [chemical binding]; other site
355276005875	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
355276005876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276005877	ATP binding site [chemical binding]; other site
355276005878	putative Mg++ binding site [ion binding]; other site
355276005879	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276005880	nucleotide binding region [chemical binding]; other site
355276005881	ATP-binding site [chemical binding]; other site
355276005882	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
355276005883	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
355276005884	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
355276005885	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
355276005886	Part of AAA domain; Region: AAA_19; pfam13245
355276005887	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
355276005888	AAA domain; Region: AAA_30; pfam13604
355276005889	Family description; Region: UvrD_C_2; pfam13538
355276005890	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
355276005891	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
355276005892	Walker A/P-loop; other site
355276005893	ATP binding site [chemical binding]; other site
355276005894	Q-loop/lid; other site
355276005895	ABC transporter signature motif; other site
355276005896	Walker B; other site
355276005897	D-loop; other site
355276005898	H-loop/switch region; other site
355276005899	ABC-2 type transporter; Region: ABC2_membrane; cl17235
355276005900	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
355276005901	short chain dehydrogenase; Provisional; Region: PRK06181
355276005902	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
355276005903	putative NAD(P) binding site [chemical binding]; other site
355276005904	homotetramer interface [polypeptide binding]; other site
355276005905	active site
355276005906	homodimer interface [polypeptide binding]; other site
355276005907	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
355276005908	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
355276005909	S-adenosylmethionine binding site [chemical binding]; other site
355276005910	HDOD domain; Region: HDOD; pfam08668
355276005911	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276005912	Zn2+ binding site [ion binding]; other site
355276005913	Mg2+ binding site [ion binding]; other site
355276005914	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
355276005915	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
355276005916	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
355276005917	Walker A/P-loop; other site
355276005918	ATP binding site [chemical binding]; other site
355276005919	Q-loop/lid; other site
355276005920	ABC transporter signature motif; other site
355276005921	Walker B; other site
355276005922	D-loop; other site
355276005923	H-loop/switch region; other site
355276005924	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
355276005925	catalytic core [active]
355276005926	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
355276005927	active site
355276005928	catalytic triad [active]
355276005929	oxyanion hole [active]
355276005930	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276005931	anti sigma factor interaction site; other site
355276005932	regulatory phosphorylation site [posttranslational modification]; other site
355276005933	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
355276005934	catalytic residues [active]
355276005935	Int/Topo IB signature motif; other site
355276005936	DNA binding site [nucleotide binding]
355276005937	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
355276005938	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276005939	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276005940	ligand binding site [chemical binding]; other site
355276005941	flexible hinge region; other site
355276005942	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276005943	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
355276005944	ligand binding site [chemical binding]; other site
355276005945	flexible hinge region; other site
355276005946	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
355276005947	endonuclease III; Region: ENDO3c; smart00478
355276005948	minor groove reading motif; other site
355276005949	helix-hairpin-helix signature motif; other site
355276005950	substrate binding pocket [chemical binding]; other site
355276005951	active site
355276005952	Beta-propeller repeat; Region: SBBP; pfam06739
355276005953	Beta-propeller repeat; Region: SBBP; pfam06739
355276005954	Beta-propeller repeat; Region: SBBP; pfam06739
355276005955	Beta-propeller repeat; Region: SBBP; pfam06739
355276005956	Beta-propeller repeat; Region: SBBP; pfam06739
355276005957	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
355276005958	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
355276005959	active site
355276005960	metal binding site [ion binding]; metal-binding site
355276005961	DNA binding site [nucleotide binding]
355276005962	AAA domain; Region: AAA_23; pfam13476
355276005963	P-loop containing region of AAA domain; Region: AAA_29; cl17516
355276005964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276005965	ABC transporter signature motif; other site
355276005966	Walker B; other site
355276005967	D-loop; other site
355276005968	H-loop/switch region; other site
355276005969	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
355276005970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276005971	S-adenosylmethionine binding site [chemical binding]; other site
355276005972	Sporulation related domain; Region: SPOR; pfam05036
355276005973	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
355276005974	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
355276005975	ATP-binding [chemical binding]; other site
355276005976	CoA-binding site [chemical binding]; other site
355276005977	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
355276005978	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
355276005979	active site
355276005980	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
355276005981	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
355276005982	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
355276005983	HSP70 interaction site [polypeptide binding]; other site
355276005984	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276005985	anti sigma factor interaction site; other site
355276005986	regulatory phosphorylation site [posttranslational modification]; other site
355276005987	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
355276005988	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
355276005989	active site
355276005990	Riboflavin kinase; Region: Flavokinase; pfam01687
355276005991	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276005992	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276005993	flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664
355276005994	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
355276005995	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
355276005996	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
355276005997	amphipathic channel; other site
355276005998	Asn-Pro-Ala signature motifs; other site
355276005999	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
355276006000	dimer interface [polypeptide binding]; other site
355276006001	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276006002	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276006003	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276006004	DNA binding residues [nucleotide binding]
355276006005	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
355276006006	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
355276006007	dimer interface [polypeptide binding]; other site
355276006008	ssDNA binding site [nucleotide binding]; other site
355276006009	tetramer (dimer of dimers) interface [polypeptide binding]; other site
355276006010	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
355276006011	YceG-like family; Region: YceG; pfam02618
355276006012	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
355276006013	dimerization interface [polypeptide binding]; other site
355276006014	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276006015	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
355276006016	active site
355276006017	Substrate binding site; other site
355276006018	Mg++ binding site; other site
355276006019	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
355276006020	Ligand binding site; other site
355276006021	Putative Catalytic site; other site
355276006022	DXD motif; other site
355276006023	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
355276006024	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
355276006025	NAD binding site [chemical binding]; other site
355276006026	homotetramer interface [polypeptide binding]; other site
355276006027	homodimer interface [polypeptide binding]; other site
355276006028	active site
355276006029	substrate binding site [chemical binding]; other site
355276006030	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
355276006031	Ligand binding site; other site
355276006032	Putative Catalytic site; other site
355276006033	DXD motif; other site
355276006034	flagellin; Provisional; Region: PRK12805
355276006035	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
355276006036	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
355276006037	oligomeric interface; other site
355276006038	putative active site [active]
355276006039	homodimer interface [polypeptide binding]; other site
355276006040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006041	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006042	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006043	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
355276006044	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
355276006045	Beta-lactamase; Region: Beta-lactamase; pfam00144
355276006046	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
355276006047	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
355276006048	inhibitor-cofactor binding pocket; inhibition site
355276006049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276006050	catalytic residue [active]
355276006051	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
355276006052	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
355276006053	active site
355276006054	purine riboside binding site [chemical binding]; other site
355276006055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276006056	non-specific DNA binding site [nucleotide binding]; other site
355276006057	salt bridge; other site
355276006058	sequence-specific DNA binding site [nucleotide binding]; other site
355276006059	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
355276006060	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
355276006061	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
355276006062	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
355276006063	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
355276006064	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
355276006065	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
355276006066	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
355276006067	Response regulator receiver domain; Region: Response_reg; pfam00072
355276006068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276006069	active site
355276006070	phosphorylation site [posttranslational modification]
355276006071	intermolecular recognition site; other site
355276006072	dimerization interface [polypeptide binding]; other site
355276006073	PAS fold; Region: PAS_4; pfam08448
355276006074	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276006075	putative active site [active]
355276006076	heme pocket [chemical binding]; other site
355276006077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276006078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
355276006079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276006080	ATP binding site [chemical binding]; other site
355276006081	G-X-G motif; other site
355276006082	Phosphotransferase enzyme family; Region: APH; pfam01636
355276006083	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
355276006084	substrate binding site [chemical binding]; other site
355276006085	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
355276006086	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
355276006087	Substrate binding site; other site
355276006088	metal-binding site
355276006089	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
355276006090	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
355276006091	active site
355276006092	dimer interface [polypeptide binding]; other site
355276006093	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
355276006094	dimer interface [polypeptide binding]; other site
355276006095	active site
355276006096	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593
355276006097	ligand binding site [chemical binding]; other site
355276006098	active site
355276006099	hypothetical protein; Provisional; Region: PRK04164
355276006100	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
355276006101	SET domain; Region: SET; pfam00856
355276006102	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276006103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276006104	S-adenosylmethionine binding site [chemical binding]; other site
355276006105	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
355276006106	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
355276006107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276006108	PAS domain; Region: PAS_9; pfam13426
355276006109	putative active site [active]
355276006110	heme pocket [chemical binding]; other site
355276006111	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
355276006112	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
355276006113	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
355276006114	metal-binding site [ion binding]
355276006115	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
355276006116	Soluble P-type ATPase [General function prediction only]; Region: COG4087
355276006117	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
355276006118	metal-binding site [ion binding]
355276006119	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
355276006120	putative homodimer interface [polypeptide binding]; other site
355276006121	putative homotetramer interface [polypeptide binding]; other site
355276006122	putative allosteric switch controlling residues; other site
355276006123	putative metal binding site [ion binding]; other site
355276006124	putative homodimer-homodimer interface [polypeptide binding]; other site
355276006125	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
355276006126	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
355276006127	Sulfate transporter family; Region: Sulfate_transp; pfam00916
355276006128	Protein of unknown function (DUF806); Region: DUF806; pfam05657
355276006129	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
355276006130	active site clefts [active]
355276006131	zinc binding site [ion binding]; other site
355276006132	dimer interface [polypeptide binding]; other site
355276006133	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
355276006134	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
355276006135	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
355276006136	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
355276006137	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
355276006138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006139	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006140	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006141	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
355276006142	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
355276006143	dimer interface [polypeptide binding]; other site
355276006144	active site
355276006145	Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389
355276006146	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
355276006147	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
355276006148	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
355276006149	active site
355276006150	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
355276006151	CoA-transferase family III; Region: CoA_transf_3; pfam02515
355276006152	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
355276006153	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
355276006154	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cd11308
355276006155	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
355276006156	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
355276006157	N-terminal plug; other site
355276006158	ligand-binding site [chemical binding]; other site
355276006159	Uncharacterized conserved protein [Function unknown]; Region: COG1434
355276006160	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
355276006161	putative active site [active]
355276006162	CcmE; Region: CcmE; cl00994
355276006163	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
355276006164	Cytochrome C biogenesis protein; Region: CcmH; cl01179
355276006165	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
355276006166	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276006167	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
355276006168	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
355276006169	dimer interface [polypeptide binding]; other site
355276006170	active site
355276006171	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
355276006172	active site
355276006173	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
355276006174	active site 2 [active]
355276006175	active site 1 [active]
355276006176	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276006177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276006178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276006179	Leucine rich repeat; Region: LRR_8; pfam13855
355276006180	methionine sulfoxide reductase B; Provisional; Region: PRK00222
355276006181	SelR domain; Region: SelR; pfam01641
355276006182	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
355276006183	Putative serine esterase (DUF676); Region: DUF676; pfam05057
355276006184	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
355276006185	active site
355276006186	putative DNA-binding cleft [nucleotide binding]; other site
355276006187	dimer interface [polypeptide binding]; other site
355276006188	hypothetical protein; Validated; Region: PRK00110
355276006189	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
355276006190	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
355276006191	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
355276006192	Na binding site [ion binding]; other site
355276006193	aspartate kinase; Reviewed; Region: PRK06635
355276006194	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
355276006195	putative nucleotide binding site [chemical binding]; other site
355276006196	putative catalytic residues [active]
355276006197	putative Mg ion binding site [ion binding]; other site
355276006198	putative aspartate binding site [chemical binding]; other site
355276006199	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
355276006200	putative allosteric regulatory site; other site
355276006201	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
355276006202	putative allosteric regulatory residue; other site
355276006203	Cache domain; Region: Cache_1; pfam02743
355276006204	HAMP domain; Region: HAMP; pfam00672
355276006205	dimerization interface [polypeptide binding]; other site
355276006206	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276006207	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276006208	dimer interface [polypeptide binding]; other site
355276006209	putative CheW interface [polypeptide binding]; other site
355276006210	Cache domain; Region: Cache_1; pfam02743
355276006211	HAMP domain; Region: HAMP; pfam00672
355276006212	dimerization interface [polypeptide binding]; other site
355276006213	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276006214	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276006215	dimer interface [polypeptide binding]; other site
355276006216	putative CheW interface [polypeptide binding]; other site
355276006217	SurA N-terminal domain; Region: SurA_N_3; cl07813
355276006218	putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142
355276006219	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
355276006220	spiro-SPASM protein; Region: spiroSPASM; TIGR04321
355276006221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276006222	FeS/SAM binding site; other site
355276006223	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
355276006224	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
355276006225	ligand binding site; other site
355276006226	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
355276006227	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
355276006228	active site
355276006229	HIGH motif; other site
355276006230	nucleotide binding site [chemical binding]; other site
355276006231	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
355276006232	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
355276006233	active site
355276006234	KMSKS motif; other site
355276006235	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
355276006236	tRNA binding surface [nucleotide binding]; other site
355276006237	anticodon binding site; other site
355276006238	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
355276006239	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13789
355276006240	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
355276006241	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
355276006242	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
355276006243	peptide chain release factor 2; Validated; Region: prfB; PRK00578
355276006244	PCRF domain; Region: PCRF; pfam03462
355276006245	RF-1 domain; Region: RF-1; pfam00472
355276006246	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
355276006247	putative catalytic site [active]
355276006248	metal binding site A [ion binding]; metal-binding site
355276006249	phosphate binding site [ion binding]; other site
355276006250	metal binding site C [ion binding]; metal-binding site
355276006251	metal binding site B [ion binding]; metal-binding site
355276006252	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
355276006253	substrate binding site [chemical binding]; other site
355276006254	multimerization interface [polypeptide binding]; other site
355276006255	ATP binding site [chemical binding]; other site
355276006256	Protein required for attachment to host cells; Region: Host_attach; pfam10116
355276006257	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
355276006258	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
355276006259	nucleotide binding site [chemical binding]; other site
355276006260	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
355276006261	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
355276006262	catalytic site [active]
355276006263	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cl09113
355276006264	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276006265	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276006266	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276006267	DNA binding residues [nucleotide binding]
355276006268	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
355276006269	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
355276006270	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
355276006271	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
355276006272	proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974
355276006273	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
355276006274	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
355276006275	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
355276006276	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
355276006277	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
355276006278	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
355276006279	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
355276006280	SLBB domain; Region: SLBB; pfam10531
355276006281	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
355276006282	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
355276006283	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
355276006284	putative dimer interface [polypeptide binding]; other site
355276006285	[2Fe-2S] cluster binding site [ion binding]; other site
355276006286	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
355276006287	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
355276006288	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
355276006289	NADH dehydrogenase subunit B; Provisional; Region: PRK14814
355276006290	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
355276006291	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
355276006292	putative active site [active]
355276006293	putative catalytic site [active]
355276006294	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
355276006295	MarR family; Region: MarR_2; pfam12802
355276006296	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
355276006297	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
355276006298	pantothenate kinase; Reviewed; Region: PRK13318
355276006299	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
355276006300	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
355276006301	Methyltransferase domain; Region: Methyltransf_26; pfam13659
355276006302	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
355276006303	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
355276006304	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
355276006305	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
355276006306	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
355276006307	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
355276006308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276006309	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
355276006310	nucleotide binding site/active site [active]
355276006311	HIT family signature motif; other site
355276006312	catalytic residue [active]
355276006313	MraW methylase family; Region: Methyltransf_5; cl17771
355276006314	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
355276006315	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
355276006316	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
355276006317	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
355276006318	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
355276006319	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
355276006320	Mg++ binding site [ion binding]; other site
355276006321	putative catalytic motif [active]
355276006322	putative substrate binding site [chemical binding]; other site
355276006323	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
355276006324	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
355276006325	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
355276006326	active site
355276006327	homodimer interface [polypeptide binding]; other site
355276006328	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
355276006329	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
355276006330	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
355276006331	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
355276006332	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
355276006333	catalytic residues [active]
355276006334	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006335	binding surface
355276006336	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276006337	TPR motif; other site
355276006338	TPR repeat; Region: TPR_11; pfam13414
355276006339	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
355276006340	metal binding site [ion binding]; metal-binding site
355276006341	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
355276006342	Beta-lactamase; Region: Beta-lactamase; pfam00144
355276006343	DJ-1 family protein; Region: not_thiJ; TIGR01383
355276006344	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
355276006345	conserved cys residue [active]
355276006346	HDOD domain; Region: HDOD; pfam08668
355276006347	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
355276006348	Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134
355276006349	NAD(P) binding site [chemical binding]; other site
355276006350	catalytic residues [active]
355276006351	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
355276006352	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
355276006353	dimerization interface [polypeptide binding]; other site
355276006354	DPS ferroxidase diiron center [ion binding]; other site
355276006355	ion pore; other site
355276006356	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
355276006357	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
355276006358	inhibitor-cofactor binding pocket; inhibition site
355276006359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276006360	catalytic residue [active]
355276006361	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
355276006362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276006363	Walker A motif; other site
355276006364	ATP binding site [chemical binding]; other site
355276006365	Walker B motif; other site
355276006366	arginine finger; other site
355276006367	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
355276006368	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
355276006369	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
355276006370	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276006371	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276006372	MAPEG family; Region: MAPEG; pfam01124
355276006373	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
355276006374	PhoU domain; Region: PhoU; pfam01895
355276006375	PhoU domain; Region: PhoU; pfam01895
355276006376	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
355276006377	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
355276006378	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
355276006379	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
355276006380	NAD(P) binding site [chemical binding]; other site
355276006381	homotetramer interface [polypeptide binding]; other site
355276006382	homodimer interface [polypeptide binding]; other site
355276006383	active site
355276006384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006385	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006386	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006387	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
355276006388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276006389	S-adenosylmethionine binding site [chemical binding]; other site
355276006390	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
355276006391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006392	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006393	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006394	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
355276006395	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
355276006396	trimer interface [polypeptide binding]; other site
355276006397	active site
355276006398	UDP-GlcNAc binding site [chemical binding]; other site
355276006399	lipid binding site [chemical binding]; lipid-binding site
355276006400	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
355276006401	EamA-like transporter family; Region: EamA; pfam00892
355276006402	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
355276006403	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
355276006404	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
355276006405	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
355276006406	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
355276006407	chaperone protein DnaJ; Provisional; Region: PRK14286
355276006408	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
355276006409	HSP70 interaction site [polypeptide binding]; other site
355276006410	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
355276006411	substrate binding site [polypeptide binding]; other site
355276006412	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
355276006413	Zn binding sites [ion binding]; other site
355276006414	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
355276006415	dimer interface [polypeptide binding]; other site
355276006416	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
355276006417	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
355276006418	nucleotide binding site [chemical binding]; other site
355276006419	NEF interaction site [polypeptide binding]; other site
355276006420	SBD interface [polypeptide binding]; other site
355276006421	GrpE; Region: GrpE; pfam01025
355276006422	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
355276006423	dimer interface [polypeptide binding]; other site
355276006424	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
355276006425	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
355276006426	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
355276006427	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
355276006428	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
355276006429	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
355276006430	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
355276006431	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
355276006432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006433	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006434	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006435	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
355276006436	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
355276006437	active site
355276006438	catalytic site [active]
355276006439	metal binding site [ion binding]; metal-binding site
355276006440	dimer interface [polypeptide binding]; other site
355276006441	SET domain; Region: SET; pfam00856
355276006442	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
355276006443	putative active site [active]
355276006444	Ap4A binding site [chemical binding]; other site
355276006445	nudix motif; other site
355276006446	putative metal binding site [ion binding]; other site
355276006447	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
355276006448	Acylphosphatase; Region: Acylphosphatase; pfam00708
355276006449	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
355276006450	TrkA-N domain; Region: TrkA_N; pfam02254
355276006451	TrkA-C domain; Region: TrkA_C; pfam02080
355276006452	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
355276006453	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
355276006454	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
355276006455	active site
355276006456	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
355276006457	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
355276006458	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
355276006459	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
355276006460	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
355276006461	NADP-binding site; other site
355276006462	homotetramer interface [polypeptide binding]; other site
355276006463	substrate binding site [chemical binding]; other site
355276006464	homodimer interface [polypeptide binding]; other site
355276006465	active site
355276006466	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
355276006467	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
355276006468	active site
355276006469	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
355276006470	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
355276006471	NAD binding site [chemical binding]; other site
355276006472	homodimer interface [polypeptide binding]; other site
355276006473	active site
355276006474	substrate binding site [chemical binding]; other site
355276006475	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
355276006476	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
355276006477	ThiC-associated domain; Region: ThiC-associated; pfam13667
355276006478	ThiC family; Region: ThiC; pfam01964
355276006479	PemK-like protein; Region: PemK; pfam02452
355276006480	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
355276006481	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
355276006482	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
355276006483	generic binding surface II; other site
355276006484	ssDNA binding site; other site
355276006485	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276006486	ATP binding site [chemical binding]; other site
355276006487	putative Mg++ binding site [ion binding]; other site
355276006488	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276006489	nucleotide binding region [chemical binding]; other site
355276006490	ATP-binding site [chemical binding]; other site
355276006491	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
355276006492	active site
355276006493	metal binding site [ion binding]; metal-binding site
355276006494	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
355276006495	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
355276006496	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
355276006497	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
355276006498	Domain of unknown function DUF21; Region: DUF21; pfam01595
355276006499	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
355276006500	Transporter associated domain; Region: CorC_HlyC; smart01091
355276006501	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
355276006502	Flavoprotein; Region: Flavoprotein; pfam02441
355276006503	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
355276006504	AAA domain; Region: AAA_21; pfam13304
355276006505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276006506	ABC transporter signature motif; other site
355276006507	Walker B; other site
355276006508	D-loop; other site
355276006509	H-loop/switch region; other site
355276006510	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
355276006511	dimer interface [polypeptide binding]; other site
355276006512	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006513	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006514	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006515	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
355276006516	FAD binding domain; Region: FAD_binding_4; pfam01565
355276006517	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
355276006518	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276006519	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
355276006520	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
355276006521	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
355276006522	metal binding site [ion binding]; metal-binding site
355276006523	active site
355276006524	I-site; other site
355276006525	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
355276006526	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
355276006527	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
355276006528	Cation transport protein; Region: TrkH; cl17365
355276006529	Cation transport protein; Region: TrkH; cl17365
355276006530	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
355276006531	elongation factor G; Reviewed; Region: PRK12740
355276006532	G1 box; other site
355276006533	putative GEF interaction site [polypeptide binding]; other site
355276006534	GTP/Mg2+ binding site [chemical binding]; other site
355276006535	Switch I region; other site
355276006536	G2 box; other site
355276006537	G3 box; other site
355276006538	Switch II region; other site
355276006539	G4 box; other site
355276006540	G5 box; other site
355276006541	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
355276006542	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
355276006543	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
355276006544	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
355276006545	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276006546	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
355276006547	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
355276006548	active site
355276006549	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276006550	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276006551	ligand binding site [chemical binding]; other site
355276006552	flexible hinge region; other site
355276006553	Tetratricopeptide repeat; Region: TPR_6; pfam13174
355276006554	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276006555	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
355276006556	ligand binding site [chemical binding]; other site
355276006557	flexible hinge region; other site
355276006558	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006559	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006560	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006561	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
355276006562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276006563	S-adenosylmethionine binding site [chemical binding]; other site
355276006564	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
355276006565	Nitrogen regulatory protein P-II; Region: P-II; smart00938
355276006566	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
355276006567	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
355276006568	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
355276006569	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
355276006570	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
355276006571	glutaminase active site [active]
355276006572	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
355276006573	dimer interface [polypeptide binding]; other site
355276006574	active site
355276006575	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
355276006576	dimer interface [polypeptide binding]; other site
355276006577	active site
355276006578	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
355276006579	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
355276006580	active site
355276006581	substrate binding site [chemical binding]; other site
355276006582	metal binding site [ion binding]; metal-binding site
355276006583	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
355276006584	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
355276006585	Ligand binding site; other site
355276006586	Putative Catalytic site; other site
355276006587	DXD motif; other site
355276006588	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
355276006589	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276006590	S-adenosylmethionine binding site [chemical binding]; other site
355276006591	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
355276006592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
355276006593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276006594	active site
355276006595	phosphorylation site [posttranslational modification]
355276006596	intermolecular recognition site; other site
355276006597	dimerization interface [polypeptide binding]; other site
355276006598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
355276006599	DNA binding residues [nucleotide binding]
355276006600	dimerization interface [polypeptide binding]; other site
355276006601	TIGR02453 family protein; Region: TIGR02453
355276006602	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
355276006603	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
355276006604	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
355276006605	active site
355276006606	oligomerization interface [polypeptide binding]; other site
355276006607	metal binding site [ion binding]; metal-binding site
355276006608	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
355276006609	catalytic center binding site [active]
355276006610	ATP binding site [chemical binding]; other site
355276006611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276006612	Walker A motif; other site
355276006613	ATP binding site [chemical binding]; other site
355276006614	Walker B motif; other site
355276006615	arginine finger; other site
355276006616	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
355276006617	active site
355276006618	catalytic residues [active]
355276006619	metal binding site [ion binding]; metal-binding site
355276006620	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
355276006621	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
355276006622	DUF35 OB-fold domain; Region: DUF35; pfam01796
355276006623	Cytochrome c; Region: Cytochrom_C; pfam00034
355276006624	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276006625	anti sigma factor interaction site; other site
355276006626	regulatory phosphorylation site [posttranslational modification]; other site
355276006627	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
355276006628	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
355276006629	Ligand binding site; other site
355276006630	oligomer interface; other site
355276006631	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
355276006632	flagellar motor protein MotB; Validated; Region: motB; PRK06667
355276006633	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
355276006634	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276006635	ligand binding site [chemical binding]; other site
355276006636	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
355276006637	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
355276006638	Flagellar protein (FlbD); Region: FlbD; pfam06289
355276006639	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276006640	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
355276006641	putative ADP-binding pocket [chemical binding]; other site
355276006642	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
355276006643	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
355276006644	putative active site [active]
355276006645	metal binding site [ion binding]; metal-binding site
355276006646	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
355276006647	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
355276006648	DNA protecting protein DprA; Region: dprA; TIGR00732
355276006649	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
355276006650	Predicted membrane protein [Function unknown]; Region: COG4270
355276006651	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
355276006652	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
355276006653	Coenzyme A binding pocket [chemical binding]; other site
355276006654	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
355276006655	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
355276006656	Protein of unknown function (DUF433); Region: DUF433; pfam04255
355276006657	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
355276006658	homotrimer interaction site [polypeptide binding]; other site
355276006659	zinc binding site [ion binding]; other site
355276006660	CDP-binding sites; other site
355276006661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006662	binding surface
355276006663	TPR motif; other site
355276006664	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276006665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006666	binding surface
355276006667	TPR motif; other site
355276006668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006669	TPR motif; other site
355276006670	TPR repeat; Region: TPR_11; pfam13414
355276006671	binding surface
355276006672	quinolinate synthetase; Provisional; Region: PRK09375
355276006673	cell division protein FtsZ; Validated; Region: PRK09330
355276006674	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
355276006675	nucleotide binding site [chemical binding]; other site
355276006676	SulA interaction site; other site
355276006677	cell division protein FtsA; Region: ftsA; TIGR01174
355276006678	Cell division protein FtsA; Region: FtsA; smart00842
355276006679	Cell division protein FtsA; Region: FtsA; pfam14450
355276006680	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
355276006681	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
355276006682	mce related protein; Region: MCE; pfam02470
355276006683	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
355276006684	EamA-like transporter family; Region: EamA; pfam00892
355276006685	EamA-like transporter family; Region: EamA; pfam00892
355276006686	Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246
355276006687	active site
355276006688	Zn binding site [ion binding]; other site
355276006689	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
355276006690	Uncharacterized conserved protein [Function unknown]; Region: COG1262
355276006691	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
355276006692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
355276006693	Uncharacterized conserved protein [Function unknown]; Region: COG3349
355276006694	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
355276006695	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
355276006696	substrate binding site [chemical binding]; other site
355276006697	activation loop (A-loop); other site
355276006698	Predicted ATPase [General function prediction only]; Region: COG3899
355276006699	AAA ATPase domain; Region: AAA_16; pfam13191
355276006700	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276006701	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
355276006702	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276006703	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276006704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276006705	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276006706	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276006707	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
355276006708	HsdM N-terminal domain; Region: HsdM_N; pfam12161
355276006709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276006710	S-adenosylmethionine binding site [chemical binding]; other site
355276006711	AAA domain; Region: AAA_13; pfam13166
355276006712	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
355276006713	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
355276006714	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276006715	ATP binding site [chemical binding]; other site
355276006716	putative Mg++ binding site [ion binding]; other site
355276006717	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
355276006718	four helix bundle protein; Region: TIGR02436
355276006719	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
355276006720	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
355276006721	FMN binding site [chemical binding]; other site
355276006722	active site
355276006723	catalytic residues [active]
355276006724	substrate binding site [chemical binding]; other site
355276006725	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
355276006726	Uncharacterized conserved protein [Function unknown]; Region: COG4121
355276006727	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
355276006728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276006729	ATP binding site [chemical binding]; other site
355276006730	putative Mg++ binding site [ion binding]; other site
355276006731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276006732	nucleotide binding region [chemical binding]; other site
355276006733	ATP-binding site [chemical binding]; other site
355276006734	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
355276006735	HRDC domain; Region: HRDC; pfam00570
355276006736	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276006737	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276006738	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276006739	DNA binding residues [nucleotide binding]
355276006740	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
355276006741	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
355276006742	putative catalytic site [active]
355276006743	metal binding site A [ion binding]; metal-binding site
355276006744	phosphate binding site [ion binding]; other site
355276006745	metal binding site C [ion binding]; metal-binding site
355276006746	metal binding site B [ion binding]; metal-binding site
355276006747	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006748	TPR motif; other site
355276006749	binding surface
355276006750	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276006751	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006752	binding surface
355276006753	TPR motif; other site
355276006754	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276006755	enoyl-CoA hydratase; Provisional; Region: PRK06142
355276006756	substrate binding site [chemical binding]; other site
355276006757	oxyanion hole (OAH) forming residues; other site
355276006758	trimer interface [polypeptide binding]; other site
355276006759	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276006760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276006761	active site
355276006762	phosphorylation site [posttranslational modification]
355276006763	intermolecular recognition site; other site
355276006764	dimerization interface [polypeptide binding]; other site
355276006765	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276006766	PAS domain; Region: PAS_9; pfam13426
355276006767	putative active site [active]
355276006768	heme pocket [chemical binding]; other site
355276006769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
355276006770	Histidine kinase; Region: HisKA_2; pfam07568
355276006771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276006772	ATP binding site [chemical binding]; other site
355276006773	Mg2+ binding site [ion binding]; other site
355276006774	G-X-G motif; other site
355276006775	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
355276006776	MarR family; Region: MarR_2; pfam12802
355276006777	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276006778	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
355276006779	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
355276006780	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276006781	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
355276006782	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
355276006783	Transglycosylase; Region: Transgly; pfam00912
355276006784	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
355276006785	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
355276006786	diaminopimelate decarboxylase; Provisional; Region: PRK11165
355276006787	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
355276006788	active site
355276006789	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
355276006790	substrate binding site [chemical binding]; other site
355276006791	catalytic residues [active]
355276006792	dimer interface [polypeptide binding]; other site
355276006793	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
355276006794	substrate binding site; other site
355276006795	dimer interface; other site
355276006796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276006797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276006798	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
355276006799	CoenzymeA binding site [chemical binding]; other site
355276006800	subunit interaction site [polypeptide binding]; other site
355276006801	PHB binding site; other site
355276006802	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
355276006803	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
355276006804	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
355276006805	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
355276006806	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
355276006807	GTPase RsgA; Reviewed; Region: PRK01889
355276006808	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276006809	RNA binding site [nucleotide binding]; other site
355276006810	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
355276006811	GTPase/Zn-binding domain interface [polypeptide binding]; other site
355276006812	GTP/Mg2+ binding site [chemical binding]; other site
355276006813	G4 box; other site
355276006814	G5 box; other site
355276006815	G1 box; other site
355276006816	Switch I region; other site
355276006817	G2 box; other site
355276006818	G3 box; other site
355276006819	Switch II region; other site
355276006820	Fatty acid desaturase; Region: FA_desaturase; pfam00487
355276006821	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
355276006822	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
355276006823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276006824	FeS/SAM binding site; other site
355276006825	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
355276006826	dimerization interface [polypeptide binding]; other site
355276006827	putative DNA binding site [nucleotide binding]; other site
355276006828	putative Zn2+ binding site [ion binding]; other site
355276006829	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
355276006830	putative hydrophobic ligand binding site [chemical binding]; other site
355276006831	Outer membrane efflux protein; Region: OEP; pfam02321
355276006832	Outer membrane efflux protein; Region: OEP; pfam02321
355276006833	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
355276006834	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276006835	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276006836	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276006837	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
355276006838	NAD(P) binding site [chemical binding]; other site
355276006839	active site
355276006840	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
355276006841	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
355276006842	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276006843	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
355276006844	Protein export membrane protein; Region: SecD_SecF; cl14618
355276006845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276006846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276006847	dimer interface [polypeptide binding]; other site
355276006848	phosphorylation site [posttranslational modification]
355276006849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276006850	ATP binding site [chemical binding]; other site
355276006851	Mg2+ binding site [ion binding]; other site
355276006852	G-X-G motif; other site
355276006853	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
355276006854	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276006855	substrate binding site [chemical binding]; other site
355276006856	oxyanion hole (OAH) forming residues; other site
355276006857	trimer interface [polypeptide binding]; other site
355276006858	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
355276006859	Sulfatase; Region: Sulfatase; cl17466
355276006860	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
355276006861	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
355276006862	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
355276006863	active site
355276006864	catalytic site [active]
355276006865	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
355276006866	active site
355276006867	catalytic site [active]
355276006868	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
355276006869	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
355276006870	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276006871	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276006872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006873	TPR motif; other site
355276006874	binding surface
355276006875	TPR repeat; Region: TPR_11; pfam13414
355276006876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006877	binding surface
355276006878	TPR motif; other site
355276006879	TPR repeat; Region: TPR_11; pfam13414
355276006880	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
355276006881	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
355276006882	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
355276006883	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276006884	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276006885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276006886	binding surface
355276006887	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276006888	TPR motif; other site
355276006889	Transglycosylase; Region: Transgly; pfam00912
355276006890	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
355276006891	RibD C-terminal domain; Region: RibD_C; cl17279
355276006892	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
355276006893	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
355276006894	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
355276006895	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
355276006896	trimer interface [polypeptide binding]; other site
355276006897	putative metal binding site [ion binding]; other site
355276006898	phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472
355276006899	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
355276006900	putative tRNA-binding site [nucleotide binding]; other site
355276006901	B3/4 domain; Region: B3_4; pfam03483
355276006902	tRNA synthetase B5 domain; Region: B5; smart00874
355276006903	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
355276006904	dimer interface [polypeptide binding]; other site
355276006905	motif 1; other site
355276006906	motif 3; other site
355276006907	motif 2; other site
355276006908	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
355276006909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
355276006910	ATP binding site [chemical binding]; other site
355276006911	putative Mg++ binding site [ion binding]; other site
355276006912	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276006913	nucleotide binding region [chemical binding]; other site
355276006914	ATP-binding site [chemical binding]; other site
355276006915	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
355276006916	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
355276006917	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
355276006918	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
355276006919	putative acyl-acceptor binding pocket; other site
355276006920	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
355276006921	dimer interface [polypeptide binding]; other site
355276006922	substrate binding site [chemical binding]; other site
355276006923	metal binding sites [ion binding]; metal-binding site
355276006924	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
355276006925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276006926	putative substrate translocation pore; other site
355276006927	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
355276006928	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
355276006929	Uncharacterized conserved protein [Function unknown]; Region: COG1262
355276006930	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
355276006931	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
355276006932	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
355276006933	ATP binding site [chemical binding]; other site
355276006934	Mg++ binding site [ion binding]; other site
355276006935	motif III; other site
355276006936	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
355276006937	nucleotide binding region [chemical binding]; other site
355276006938	ATP-binding site [chemical binding]; other site
355276006939	Membrane transport protein; Region: Mem_trans; pfam03547
355276006940	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276006941	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
355276006942	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276006943	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276006944	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276006945	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276006946	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276006947	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
355276006948	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
355276006949	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
355276006950	homodimer interface [polypeptide binding]; other site
355276006951	metal binding site [ion binding]; metal-binding site
355276006952	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
355276006953	homodimer interface [polypeptide binding]; other site
355276006954	active site
355276006955	putative chemical substrate binding site [chemical binding]; other site
355276006956	metal binding site [ion binding]; metal-binding site
355276006957	Response regulator receiver domain; Region: Response_reg; pfam00072
355276006958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276006959	active site
355276006960	phosphorylation site [posttranslational modification]
355276006961	intermolecular recognition site; other site
355276006962	dimerization interface [polypeptide binding]; other site
355276006963	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
355276006964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276006965	active site
355276006966	phosphorylation site [posttranslational modification]
355276006967	intermolecular recognition site; other site
355276006968	dimerization interface [polypeptide binding]; other site
355276006969	isocitrate dehydrogenase; Validated; Region: PRK08299
355276006970	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
355276006971	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
355276006972	putative active site [active]
355276006973	catalytic triad [active]
355276006974	putative dimer interface [polypeptide binding]; other site
355276006975	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
355276006976	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
355276006977	hinge; other site
355276006978	active site
355276006979	ferredoxin-type protein; Provisional; Region: PRK10194
355276006980	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
355276006981	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
355276006982	Putative serine esterase (DUF676); Region: DUF676; pfam05057
355276006983	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
355276006984	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
355276006985	dimer interface [polypeptide binding]; other site
355276006986	[2Fe-2S] cluster binding site [ion binding]; other site
355276006987	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
355276006988	amidophosphoribosyltransferase; Provisional; Region: PRK09123
355276006989	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
355276006990	active site
355276006991	tetramer interface [polypeptide binding]; other site
355276006992	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
355276006993	active site
355276006994	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
355276006995	catalytic site [active]
355276006996	putative active site [active]
355276006997	putative substrate binding site [chemical binding]; other site
355276006998	HRDC domain; Region: HRDC; pfam00570
355276006999	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
355276007000	putative active site [active]
355276007001	putative CoA binding site [chemical binding]; other site
355276007002	nudix motif; other site
355276007003	metal binding site [ion binding]; metal-binding site
355276007004	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
355276007005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276007006	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276007007	DNA binding residues [nucleotide binding]
355276007008	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
355276007009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276007010	active site
355276007011	phosphorylation site [posttranslational modification]
355276007012	intermolecular recognition site; other site
355276007013	dimerization interface [polypeptide binding]; other site
355276007014	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
355276007015	DNA binding site [nucleotide binding]
355276007016	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276007017	dimerization interface [polypeptide binding]; other site
355276007018	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
355276007019	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276007020	dimer interface [polypeptide binding]; other site
355276007021	phosphorylation site [posttranslational modification]
355276007022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276007023	ATP binding site [chemical binding]; other site
355276007024	Mg2+ binding site [ion binding]; other site
355276007025	G-X-G motif; other site
355276007026	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
355276007027	heterotetramer interface [polypeptide binding]; other site
355276007028	active site pocket [active]
355276007029	cleavage site
355276007030	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276007031	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276007032	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
355276007033	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
355276007034	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
355276007035	nucleotide binding pocket [chemical binding]; other site
355276007036	K-X-D-G motif; other site
355276007037	catalytic site [active]
355276007038	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
355276007039	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
355276007040	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
355276007041	Dimer interface [polypeptide binding]; other site
355276007042	BRCT sequence motif; other site
355276007043	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276007044	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276007045	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276007046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276007047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276007048	DNA binding residues [nucleotide binding]
355276007049	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
355276007050	dimer interface [polypeptide binding]; other site
355276007051	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
355276007052	putative active site [active]
355276007053	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
355276007054	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
355276007055	NADP-binding site; other site
355276007056	homotetramer interface [polypeptide binding]; other site
355276007057	substrate binding site [chemical binding]; other site
355276007058	homodimer interface [polypeptide binding]; other site
355276007059	active site
355276007060	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276007061	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
355276007062	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276007063	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
355276007064	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
355276007065	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276007066	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
355276007067	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
355276007068	active site
355276007069	dimerization interface [polypeptide binding]; other site
355276007070	Uncharacterized conserved protein [Function unknown]; Region: COG3339
355276007071	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
355276007072	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
355276007073	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
355276007074	classical (c) SDRs; Region: SDR_c; cd05233
355276007075	NAD(P) binding site [chemical binding]; other site
355276007076	active site
355276007077	Predicted amidohydrolase [General function prediction only]; Region: COG0388
355276007078	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
355276007079	putative active site [active]
355276007080	catalytic triad [active]
355276007081	putative dimer interface [polypeptide binding]; other site
355276007082	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
355276007083	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
355276007084	RNA binding surface [nucleotide binding]; other site
355276007085	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
355276007086	active site
355276007087	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276007088	ligand binding site [chemical binding]; other site
355276007089	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
355276007090	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
355276007091	non-specific DNA binding site [nucleotide binding]; other site
355276007092	salt bridge; other site
355276007093	sequence-specific DNA binding site [nucleotide binding]; other site
355276007094	fumarate hydratase; Reviewed; Region: fumC; PRK00485
355276007095	Class II fumarases; Region: Fumarase_classII; cd01362
355276007096	active site
355276007097	tetramer interface [polypeptide binding]; other site
355276007098	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276007099	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
355276007100	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
355276007101	trmE is a tRNA modification GTPase; Region: trmE; cd04164
355276007102	G1 box; other site
355276007103	GTP/Mg2+ binding site [chemical binding]; other site
355276007104	Switch I region; other site
355276007105	G2 box; other site
355276007106	Switch II region; other site
355276007107	G3 box; other site
355276007108	G4 box; other site
355276007109	G5 box; other site
355276007110	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
355276007111	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
355276007112	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
355276007113	G-X-X-G motif; other site
355276007114	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
355276007115	RxxxH motif; other site
355276007116	membrane protein insertase; Provisional; Region: PRK01318
355276007117	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
355276007118	hypothetical protein; Provisional; Region: PRK14391
355276007119	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
355276007120	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
355276007121	cyclase homology domain; Region: CHD; cd07302
355276007122	nucleotidyl binding site; other site
355276007123	metal binding site [ion binding]; metal-binding site
355276007124	dimer interface [polypeptide binding]; other site
355276007125	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
355276007126	4Fe-4S binding domain; Region: Fer4; pfam00037
355276007127	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
355276007128	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
355276007129	catalytic loop [active]
355276007130	iron binding site [ion binding]; other site
355276007131	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
355276007132	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
355276007133	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
355276007134	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
355276007135	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
355276007136	Tetramer interface [polypeptide binding]; other site
355276007137	active site
355276007138	FMN-binding site [chemical binding]; other site
355276007139	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
355276007140	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
355276007141	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
355276007142	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
355276007143	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
355276007144	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
355276007145	Walker A/P-loop; other site
355276007146	ATP binding site [chemical binding]; other site
355276007147	Q-loop/lid; other site
355276007148	ABC transporter signature motif; other site
355276007149	Walker B; other site
355276007150	D-loop; other site
355276007151	H-loop/switch region; other site
355276007152	SET domain; Region: SET; pfam00856
355276007153	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
355276007154	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276007155	GAF domain; Region: GAF; pfam01590
355276007156	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
355276007157	GAF domain; Region: GAF; pfam01590
355276007158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
355276007159	Walker A motif; other site
355276007160	ATP binding site [chemical binding]; other site
355276007161	Walker B motif; other site
355276007162	arginine finger; other site
355276007163	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
355276007164	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
355276007165	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
355276007166	Ligand Binding Site [chemical binding]; other site
355276007167	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
355276007168	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
355276007169	G1 box; other site
355276007170	GTP/Mg2+ binding site [chemical binding]; other site
355276007171	Switch I region; other site
355276007172	G2 box; other site
355276007173	G3 box; other site
355276007174	Switch II region; other site
355276007175	G4 box; other site
355276007176	G5 box; other site
355276007177	PilZ domain; Region: PilZ; pfam07238
355276007178	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
355276007179	dimer interface [polypeptide binding]; other site
355276007180	substrate binding site [chemical binding]; other site
355276007181	ATP binding site [chemical binding]; other site
355276007182	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
355276007183	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
355276007184	DNA binding site [nucleotide binding]
355276007185	active site
355276007186	GAF domain; Region: GAF_3; pfam13492
355276007187	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276007188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276007189	ATP binding site [chemical binding]; other site
355276007190	Mg2+ binding site [ion binding]; other site
355276007191	G-X-G motif; other site
355276007192	GTPase RsgA; Reviewed; Region: PRK00098
355276007193	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
355276007194	RNA binding site [nucleotide binding]; other site
355276007195	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
355276007196	GTPase/Zn-binding domain interface [polypeptide binding]; other site
355276007197	GTP/Mg2+ binding site [chemical binding]; other site
355276007198	G4 box; other site
355276007199	G5 box; other site
355276007200	G1 box; other site
355276007201	Switch I region; other site
355276007202	G2 box; other site
355276007203	G3 box; other site
355276007204	Switch II region; other site
355276007205	FecR protein; Region: FecR; pfam04773
355276007206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007207	binding surface
355276007208	TPR motif; other site
355276007209	TPR repeat; Region: TPR_11; pfam13414
355276007210	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007211	binding surface
355276007212	TPR motif; other site
355276007213	TPR repeat; Region: TPR_11; pfam13414
355276007214	TPR repeat; Region: TPR_11; pfam13414
355276007215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007216	TPR motif; other site
355276007217	binding surface
355276007218	TPR repeat; Region: TPR_11; pfam13414
355276007219	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007220	binding surface
355276007221	TPR motif; other site
355276007222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007223	binding surface
355276007224	TPR motif; other site
355276007225	TPR repeat; Region: TPR_11; pfam13414
355276007226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007227	TPR motif; other site
355276007228	binding surface
355276007229	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
355276007230	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007231	binding surface
355276007232	TPR motif; other site
355276007233	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007234	TPR motif; other site
355276007235	binding surface
355276007236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007237	binding surface
355276007238	TPR motif; other site
355276007239	Putative methyltransferase; Region: Methyltransf_4; cl17290
355276007240	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
355276007241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007242	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007243	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007244	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
355276007245	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
355276007246	Maf-like protein; Region: Maf; pfam02545
355276007247	active site
355276007248	dimer interface [polypeptide binding]; other site
355276007249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007250	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007251	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007252	seryl-tRNA synthetase; Provisional; Region: PRK05431
355276007253	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
355276007254	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
355276007255	dimer interface [polypeptide binding]; other site
355276007256	active site
355276007257	motif 1; other site
355276007258	motif 2; other site
355276007259	motif 3; other site
355276007260	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
355276007261	active site
355276007262	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
355276007263	Peptidase family M23; Region: Peptidase_M23; pfam01551
355276007264	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
355276007265	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
355276007266	Protein of unknown function (DUF327); Region: DUF327; pfam03885
355276007267	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
355276007268	ParB-like nuclease domain; Region: ParB; smart00470
355276007269	KorB domain; Region: KorB; pfam08535
355276007270	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
355276007271	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276007272	P-loop; other site
355276007273	Magnesium ion binding site [ion binding]; other site
355276007274	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276007275	Magnesium ion binding site [ion binding]; other site
355276007276	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
355276007277	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
355276007278	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
355276007279	active site
355276007280	catalytic residue [active]
355276007281	dimer interface [polypeptide binding]; other site
355276007282	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
355276007283	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
355276007284	putative active site [active]
355276007285	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
355276007286	transcriptional activator RfaH; Region: RfaH; TIGR01955
355276007287	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
355276007288	PAS domain; Region: PAS_9; pfam13426
355276007289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276007290	putative active site [active]
355276007291	heme pocket [chemical binding]; other site
355276007292	UbiA prenyltransferase family; Region: UbiA; pfam01040
355276007293	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
355276007294	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
355276007295	dimer interface [polypeptide binding]; other site
355276007296	putative CheW interface [polypeptide binding]; other site
355276007297	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
355276007298	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
355276007299	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
355276007300	NAD binding site [chemical binding]; other site
355276007301	putative substrate binding site 2 [chemical binding]; other site
355276007302	putative substrate binding site 1 [chemical binding]; other site
355276007303	active site
355276007304	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
355276007305	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
355276007306	ligand binding site [chemical binding]; other site
355276007307	homodimer interface [polypeptide binding]; other site
355276007308	NAD(P) binding site [chemical binding]; other site
355276007309	trimer interface B [polypeptide binding]; other site
355276007310	trimer interface A [polypeptide binding]; other site
355276007311	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
355276007312	active site
355276007313	histidyl-tRNA synthetase; Region: hisS; TIGR00442
355276007314	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
355276007315	dimer interface [polypeptide binding]; other site
355276007316	motif 1; other site
355276007317	active site
355276007318	motif 2; other site
355276007319	motif 3; other site
355276007320	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
355276007321	anticodon binding site; other site
355276007322	Protein of unknown function (DUF1577); Region: DUF1577; pfam07614
355276007323	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
355276007324	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
355276007325	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
355276007326	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276007327	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
355276007328	ligand binding site [chemical binding]; other site
355276007329	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
355276007330	dihydropteroate synthase; Region: DHPS; TIGR01496
355276007331	substrate binding pocket [chemical binding]; other site
355276007332	dimer interface [polypeptide binding]; other site
355276007333	inhibitor binding site; inhibition site
355276007334	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
355276007335	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276007336	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
355276007337	DNA binding residues [nucleotide binding]
355276007338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007339	binding surface
355276007340	TPR motif; other site
355276007341	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276007342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007343	binding surface
355276007344	Tetratricopeptide repeat; Region: TPR_12; pfam13424
355276007345	TPR motif; other site
355276007346	TPR repeat; Region: TPR_11; pfam13414
355276007347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007348	TPR motif; other site
355276007349	binding surface
355276007350	rare lipoprotein A; Region: rlpA; TIGR00413
355276007351	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
355276007352	Sporulation related domain; Region: SPOR; pfam05036
355276007353	serine O-acetyltransferase; Region: cysE; TIGR01172
355276007354	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
355276007355	trimer interface [polypeptide binding]; other site
355276007356	active site
355276007357	substrate binding site [chemical binding]; other site
355276007358	CoA binding site [chemical binding]; other site
355276007359	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
355276007360	Peptidase family M50; Region: Peptidase_M50; pfam02163
355276007361	active site
355276007362	putative substrate binding region [chemical binding]; other site
355276007363	Uncharacterized conserved protein [Function unknown]; Region: COG3391
355276007364	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
355276007365	putative efflux protein, MATE family; Region: matE; TIGR00797
355276007366	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
355276007367	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
355276007368	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
355276007369	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
355276007370	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
355276007371	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276007372	dimerization interface [polypeptide binding]; other site
355276007373	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276007374	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276007375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007376	binding surface
355276007377	Tetratricopeptide repeat; Region: TPR_16; pfam13432
355276007378	TPR motif; other site
355276007379	TPR repeat; Region: TPR_11; pfam13414
355276007380	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
355276007381	Zn binding site [ion binding]; other site
355276007382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276007383	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276007384	dimerization interface [polypeptide binding]; other site
355276007385	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276007386	TPR repeat; Region: TPR_11; pfam13414
355276007387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007388	binding surface
355276007389	TPR motif; other site
355276007390	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
355276007391	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
355276007392	trimer interface [polypeptide binding]; other site
355276007393	active site
355276007394	enoyl-CoA hydratase; Provisional; Region: PRK07657
355276007395	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
355276007396	substrate binding site [chemical binding]; other site
355276007397	oxyanion hole (OAH) forming residues; other site
355276007398	trimer interface [polypeptide binding]; other site
355276007399	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
355276007400	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
355276007401	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
355276007402	active site
355276007403	metal binding site [ion binding]; metal-binding site
355276007404	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
355276007405	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
355276007406	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276007407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007408	S-adenosylmethionine binding site [chemical binding]; other site
355276007409	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
355276007410	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
355276007411	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
355276007412	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
355276007413	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
355276007414	putative acyl-acceptor binding pocket; other site
355276007415	Uncharacterized conserved protein [Function unknown]; Region: COG5439
355276007416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
355276007417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007418	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007419	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007420	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
355276007421	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
355276007422	putative metal binding site [ion binding]; other site
355276007423	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
355276007424	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276007425	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
355276007426	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
355276007427	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276007428	P-loop; other site
355276007429	Magnesium ion binding site [ion binding]; other site
355276007430	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276007431	Magnesium ion binding site [ion binding]; other site
355276007432	ParB-like nuclease domain; Region: ParB; smart00470
355276007433	Helix-turn-helix domain; Region: HTH_36; pfam13730
355276007434	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
355276007435	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
355276007436	FAD binding site [chemical binding]; other site
355276007437	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
355276007438	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
355276007439	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
355276007440	active site
355276007441	motif I; other site
355276007442	motif II; other site
355276007443	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
355276007444	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
355276007445	NAD(P) binding pocket [chemical binding]; other site
355276007446	porphobilinogen deaminase; Region: hemC; TIGR00212
355276007447	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
355276007448	domain interfaces; other site
355276007449	active site
355276007450	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
355276007451	dimer interface [polypeptide binding]; other site
355276007452	active site
355276007453	Schiff base residues; other site
355276007454	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
355276007455	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
355276007456	inhibitor-cofactor binding pocket; inhibition site
355276007457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276007458	catalytic residue [active]
355276007459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
355276007460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276007461	dimer interface [polypeptide binding]; other site
355276007462	phosphorylation site [posttranslational modification]
355276007463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276007464	Mg2+ binding site [ion binding]; other site
355276007465	G-X-G motif; other site
355276007466	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
355276007467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276007468	active site
355276007469	phosphorylation site [posttranslational modification]
355276007470	intermolecular recognition site; other site
355276007471	dimerization interface [polypeptide binding]; other site
355276007472	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
355276007473	DNA binding site [nucleotide binding]
355276007474	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
355276007475	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
355276007476	HemN C-terminal domain; Region: HemN_C; pfam06969
355276007477	protoporphyrinogen oxidase; Region: PLN02576
355276007478	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
355276007479	Ferrochelatase; Region: Ferrochelatase; pfam00762
355276007480	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
355276007481	C-terminal domain interface [polypeptide binding]; other site
355276007482	active site
355276007483	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
355276007484	active site
355276007485	N-terminal domain interface [polypeptide binding]; other site
355276007486	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
355276007487	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276007488	P-loop; other site
355276007489	Magnesium ion binding site [ion binding]; other site
355276007490	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
355276007491	Magnesium ion binding site [ion binding]; other site
355276007492	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
355276007493	ParB-like nuclease domain; Region: ParB; smart00470
355276007494	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
355276007495	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
355276007496	Acyltransferase family; Region: Acyl_transf_3; pfam01757
355276007497	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
355276007498	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
355276007499	ligand binding site [chemical binding]; other site
355276007500	flexible hinge region; other site
355276007501	short chain dehydrogenase; Provisional; Region: PRK08251
355276007502	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
355276007503	putative NAD(P) binding site [chemical binding]; other site
355276007504	active site
355276007505	Low molecular weight phosphatase family; Region: LMWPc; cd00115
355276007506	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
355276007507	active site
355276007508	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
355276007509	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
355276007510	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
355276007511	putative active site [active]
355276007512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
355276007513	short chain dehydrogenase; Provisional; Region: PRK06181
355276007514	NAD(P) binding site [chemical binding]; other site
355276007515	active site
355276007516	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
355276007517	putative hydrophobic ligand binding site [chemical binding]; other site
355276007518	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
355276007519	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
355276007520	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
355276007521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
355276007522	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
355276007523	MoxR-like ATPases [General function prediction only]; Region: COG0714
355276007524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
355276007525	Walker A motif; other site
355276007526	ATP binding site [chemical binding]; other site
355276007527	Walker B motif; other site
355276007528	arginine finger; other site
355276007529	Protein of unknown function DUF58; Region: DUF58; pfam01882
355276007530	Aerotolerance regulator N-terminal; Region: BatA; cl06567
355276007531	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
355276007532	metal ion-dependent adhesion site (MIDAS); other site
355276007533	Serpentine type 7TM GPCR chemoreceptor Sru; Region: 7TM_GPCR_Sru; pfam10322
355276007534	von Willebrand factor type A domain; Region: VWA_2; pfam13519
355276007535	metal ion-dependent adhesion site (MIDAS); other site
355276007536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007537	binding surface
355276007538	TPR motif; other site
355276007539	TPR repeat; Region: TPR_11; pfam13414
355276007540	Oxygen tolerance; Region: BatD; pfam13584
355276007541	heat shock protein 90; Provisional; Region: PRK05218
355276007542	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276007543	ATP binding site [chemical binding]; other site
355276007544	Mg2+ binding site [ion binding]; other site
355276007545	G-X-G motif; other site
355276007546	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
355276007547	anti sigma factor interaction site; other site
355276007548	regulatory phosphorylation site [posttranslational modification]; other site
355276007549	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
355276007550	Fatty acid desaturase; Region: FA_desaturase; pfam00487
355276007551	Di-iron ligands [ion binding]; other site
355276007552	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
355276007553	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
355276007554	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
355276007555	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276007556	LAO/AO transport system ATPase; Region: lao; TIGR00750
355276007557	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
355276007558	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
355276007559	G4 box; other site
355276007560	G5 box; other site
355276007561	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
355276007562	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
355276007563	B12 binding site [chemical binding]; other site
355276007564	cobalt ligand [ion binding]; other site
355276007565	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276007566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007567	S-adenosylmethionine binding site [chemical binding]; other site
355276007568	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
355276007569	FecR protein; Region: FecR; pfam04773
355276007570	Cache domain; Region: Cache_1; pfam02743
355276007571	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
355276007572	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
355276007573	metal binding site [ion binding]; metal-binding site
355276007574	active site
355276007575	I-site; other site
355276007576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007577	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007578	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007579	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276007580	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276007581	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
355276007582	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
355276007583	Helix-turn-helix domain; Region: HTH_18; pfam12833
355276007584	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
355276007585	Helix-turn-helix domain; Region: HTH_18; pfam12833
355276007586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
355276007587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
355276007588	dimerization interface [polypeptide binding]; other site
355276007589	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276007590	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276007591	Patatin-like phospholipase; Region: Patatin; pfam01734
355276007592	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
355276007593	Methyltransferase domain; Region: Methyltransf_31; pfam13847
355276007594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007595	S-adenosylmethionine binding site [chemical binding]; other site
355276007596	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
355276007597	putative active site [active]
355276007598	putative metal binding site [ion binding]; other site
355276007599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
355276007600	binding surface
355276007601	TPR motif; other site
355276007602	TPR repeat; Region: TPR_11; pfam13414
355276007603	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
355276007604	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
355276007605	active site
355276007606	motif I; other site
355276007607	motif II; other site
355276007608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
355276007609	Protein of unknown function (DUF1564); Region: DUF1564; pfam07600
355276007610	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
355276007611	dimerization interface [polypeptide binding]; other site
355276007612	putative DNA binding site [nucleotide binding]; other site
355276007613	putative Zn2+ binding site [ion binding]; other site
355276007614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007615	Methyltransferase domain; Region: Methyltransf_23; pfam13489
355276007616	S-adenosylmethionine binding site [chemical binding]; other site
355276007617	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
355276007618	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
355276007619	homotetramer interface [polypeptide binding]; other site
355276007620	ligand binding site [chemical binding]; other site
355276007621	catalytic site [active]
355276007622	NAD binding site [chemical binding]; other site
355276007623	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
355276007624	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
355276007625	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
355276007626	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
355276007627	substrate binding pocket [chemical binding]; other site
355276007628	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
355276007629	B12 binding site [chemical binding]; other site
355276007630	cobalt ligand [ion binding]; other site
355276007631	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
355276007632	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
355276007633	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
355276007634	active site
355276007635	ADP/pyrophosphate binding site [chemical binding]; other site
355276007636	dimerization interface [polypeptide binding]; other site
355276007637	allosteric effector site; other site
355276007638	fructose-1,6-bisphosphate binding site; other site
355276007639	GAF domain; Region: GAF_2; pfam13185
355276007640	GAF domain; Region: GAF; pfam01590
355276007641	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
355276007642	GAF domain; Region: GAF; pfam01590
355276007643	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
355276007644	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
355276007645	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
355276007646	homohexameric interface [polypeptide binding]; other site
355276007647	feedback inhibition sensing region; other site
355276007648	nucleotide binding site [chemical binding]; other site
355276007649	N-acetyl-L-glutamate binding site [chemical binding]; other site
355276007650	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
355276007651	classical (c) SDRs; Region: SDR_c; cd05233
355276007652	NAD(P) binding site [chemical binding]; other site
355276007653	active site
355276007654	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
355276007655	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
355276007656	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
355276007657	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
355276007658	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
355276007659	catalytic triad [active]
355276007660	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
355276007661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007662	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007663	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007664	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
355276007665	active site
355276007666	DNA binding site [nucleotide binding]
355276007667	Int/Topo IB signature motif; other site
355276007668	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
355276007669	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
355276007670	ADP binding site [chemical binding]; other site
355276007671	magnesium binding site [ion binding]; other site
355276007672	putative shikimate binding site; other site
355276007673	HDOD domain; Region: HDOD; pfam08668
355276007674	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
355276007675	Zn2+ binding site [ion binding]; other site
355276007676	Mg2+ binding site [ion binding]; other site
355276007677	CheD chemotactic sensory transduction; Region: CheD; cl00810
355276007678	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
355276007679	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
355276007680	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
355276007681	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
355276007682	putative active site [active]
355276007683	heme pocket [chemical binding]; other site
355276007684	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
355276007685	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
355276007686	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
355276007687	active site
355276007688	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
355276007689	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
355276007690	active site
355276007691	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
355276007692	Interdomain contacts; other site
355276007693	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
355276007694	Cytokine receptor motif; other site
355276007695	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
355276007696	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
355276007697	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
355276007698	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
355276007699	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
355276007700	membrane ATPase/protein kinase; Provisional; Region: PRK09435
355276007701	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
355276007702	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
355276007703	Walker A; other site
355276007704	G1 box; other site
355276007705	GTP/Mg2+ binding site [chemical binding]; other site
355276007706	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
355276007707	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
355276007708	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
355276007709	active site
355276007710	substrate binding site [chemical binding]; other site
355276007711	coenzyme B12 binding site [chemical binding]; other site
355276007712	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
355276007713	B12 binding site [chemical binding]; other site
355276007714	cobalt ligand [ion binding]; other site
355276007715	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
355276007716	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
355276007717	heterodimer interface [polypeptide binding]; other site
355276007718	substrate interaction site [chemical binding]; other site
355276007719	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
355276007720	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
355276007721	YhhN-like protein; Region: YhhN; pfam07947
355276007722	Uncharacterized conserved protein [Function unknown]; Region: COG1633
355276007723	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
355276007724	diiron binding motif [ion binding]; other site
355276007725	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
355276007726	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
355276007727	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
355276007728	catalytic residue [active]
355276007729	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007730	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007731	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007732	Protease prsW family; Region: PrsW-protease; pfam13367
355276007733	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
355276007734	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
355276007735	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007736	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007737	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007738	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
355276007739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007740	S-adenosylmethionine binding site [chemical binding]; other site
355276007741	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
355276007742	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
355276007743	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
355276007744	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
355276007745	homodimer interface [polypeptide binding]; other site
355276007746	metal binding site [ion binding]; metal-binding site
355276007747	Protein of unknown function (DUF1574); Region: DUF1574; pfam07611
355276007748	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276007749	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
355276007750	catalytic triad [active]
355276007751	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276007752	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
355276007753	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
355276007754	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
355276007755	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
355276007756	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
355276007757	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
355276007758	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
355276007759	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
355276007760	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276007761	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
355276007762	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
355276007763	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
355276007764	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
355276007765	N-terminal plug; other site
355276007766	ligand-binding site [chemical binding]; other site
355276007767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276007768	Major Facilitator Superfamily; Region: MFS_1; pfam07690
355276007769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276007770	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
355276007771	heme binding pocket [chemical binding]; other site
355276007772	heme ligand [chemical binding]; other site
355276007773	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
355276007774	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
355276007775	protein binding site [polypeptide binding]; other site
355276007776	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
355276007777	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
355276007778	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
355276007779	protein binding site [polypeptide binding]; other site
355276007780	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
355276007781	active site
355276007782	heat shock protein HtpX; Provisional; Region: PRK05457
355276007783	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
355276007784	Sulfate transporter family; Region: Sulfate_transp; pfam00916
355276007785	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
355276007786	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
355276007787	NAD(P) binding site [chemical binding]; other site
355276007788	homodimer interface [polypeptide binding]; other site
355276007789	substrate binding site [chemical binding]; other site
355276007790	active site
355276007791	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
355276007792	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
355276007793	putative active site [active]
355276007794	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
355276007795	putative active site [active]
355276007796	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
355276007797	dimer interface [polypeptide binding]; other site
355276007798	[2Fe-2S] cluster binding site [ion binding]; other site
355276007799	Protein of unknown function (DUF3209); Region: DUF3209; pfam11483
355276007800	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
355276007801	FAD binding pocket [chemical binding]; other site
355276007802	conserved FAD binding motif [chemical binding]; other site
355276007803	phosphate binding motif [ion binding]; other site
355276007804	beta-alpha-beta structure motif; other site
355276007805	NAD binding pocket [chemical binding]; other site
355276007806	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
355276007807	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
355276007808	Precorrin-8X methylmutase; Region: CbiC; pfam02570
355276007809	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
355276007810	active site
355276007811	putative homodimer interface [polypeptide binding]; other site
355276007812	SAM binding site [chemical binding]; other site
355276007813	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
355276007814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007815	S-adenosylmethionine binding site [chemical binding]; other site
355276007816	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
355276007817	homodimer interface [polypeptide binding]; other site
355276007818	active site
355276007819	SAM binding site [chemical binding]; other site
355276007820	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
355276007821	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
355276007822	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
355276007823	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
355276007824	active site
355276007825	SAM binding site [chemical binding]; other site
355276007826	homodimer interface [polypeptide binding]; other site
355276007827	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
355276007828	active site
355276007829	SAM binding site [chemical binding]; other site
355276007830	homodimer interface [polypeptide binding]; other site
355276007831	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
355276007832	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
355276007833	homodimer interface [polypeptide binding]; other site
355276007834	Walker A motif; other site
355276007835	ATP binding site [chemical binding]; other site
355276007836	hydroxycobalamin binding site [chemical binding]; other site
355276007837	Walker B motif; other site
355276007838	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
355276007839	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
355276007840	catalytic triad [active]
355276007841	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
355276007842	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
355276007843	homotrimer interface [polypeptide binding]; other site
355276007844	Walker A motif; other site
355276007845	GTP binding site [chemical binding]; other site
355276007846	Walker B motif; other site
355276007847	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
355276007848	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
355276007849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
355276007850	homodimer interface [polypeptide binding]; other site
355276007851	catalytic residue [active]
355276007852	cobyric acid synthase; Provisional; Region: PRK00784
355276007853	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
355276007854	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
355276007855	catalytic triad [active]
355276007856	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
355276007857	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
355276007858	catalytic core [active]
355276007859	Protein of unknown function (DUF1561); Region: DUF1561; pfam07598
355276007860	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
355276007861	Transposase; Region: DEDD_Tnp_IS110; pfam01548
355276007862	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
355276007863	Integrase core domain; Region: rve_3; pfam13683
355276007864	Integrase core domain; Region: rve; pfam00665
355276007865	FecR protein; Region: FecR; pfam04773
355276007866	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
355276007867	FecR protein; Region: FecR; pfam04773
355276007868	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
355276007869	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
355276007870	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
355276007871	DNA binding residues [nucleotide binding]
355276007872	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
355276007873	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
355276007874	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
355276007875	active site
355276007876	nucleophile elbow; other site
355276007877	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
355276007878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
355276007879	putative substrate translocation pore; other site
355276007880	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
355276007881	putative active site [active]
355276007882	putative metal binding site [ion binding]; other site
355276007883	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
355276007884	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
355276007885	active site
355276007886	FMN binding site [chemical binding]; other site
355276007887	substrate binding site [chemical binding]; other site
355276007888	3Fe-4S cluster binding site [ion binding]; other site
355276007889	Yip1 domain; Region: Yip1; pfam04893
355276007890	classical (c) SDRs; Region: SDR_c; cd05233
355276007891	short chain dehydrogenase; Provisional; Region: PRK07454
355276007892	NAD(P) binding site [chemical binding]; other site
355276007893	active site
355276007894	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
355276007895	intersubunit interface [polypeptide binding]; other site
355276007896	active site
355276007897	Zn2+ binding site [ion binding]; other site
355276007898	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
355276007899	Cupin domain; Region: Cupin_2; pfam07883
355276007900	elongation factor P; Validated; Region: PRK00529
355276007901	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
355276007902	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
355276007903	RNA binding site [nucleotide binding]; other site
355276007904	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
355276007905	RNA binding site [nucleotide binding]; other site
355276007906	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
355276007907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
355276007908	FeS/SAM binding site; other site
355276007909	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
355276007910	Predicted membrane protein [Function unknown]; Region: COG1238
355276007911	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
355276007912	active site
355276007913	dimer interface [polypeptide binding]; other site
355276007914	spermidine synthase; Provisional; Region: PRK00811
355276007915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
355276007916	S-adenosylmethionine binding site [chemical binding]; other site
355276007917	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
355276007918	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
355276007919	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
355276007920	alanine racemase; Reviewed; Region: alr; PRK00053
355276007921	active site
355276007922	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
355276007923	dimer interface [polypeptide binding]; other site
355276007924	substrate binding site [chemical binding]; other site
355276007925	catalytic residues [active]
355276007926	Phosphate acyltransferases; Region: PlsC; smart00563
355276007927	putative acyl-acceptor binding pocket; other site
355276007928	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
355276007929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
355276007930	dimer interface [polypeptide binding]; other site
355276007931	phosphorylation site [posttranslational modification]
355276007932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
355276007933	ATP binding site [chemical binding]; other site
355276007934	Mg2+ binding site [ion binding]; other site
355276007935	G-X-G motif; other site
355276007936	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
355276007937	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
355276007938	N-acetyl-D-glucosamine binding site [chemical binding]; other site
355276007939	catalytic residue [active]
355276007940	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
355276007941	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
355276007942	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
355276007943	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
355276007944	substrate binding site [chemical binding]; other site
355276007945	ligand binding site [chemical binding]; other site
355276007946	Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578
355276007947	substrate binding site [chemical binding]; other site
355276007948	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
355276007949	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
355276007950	ligand binding site [chemical binding]; other site
355276007951	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
355276007952	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
355276007953	motif 1; other site
355276007954	dimer interface [polypeptide binding]; other site
355276007955	active site
355276007956	motif 2; other site
355276007957	motif 3; other site
355276007958	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
355276007959	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
355276007960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
355276007961	active site
355276007962	phosphorylation site [posttranslational modification]
355276007963	intermolecular recognition site; other site
355276007964	dimerization interface [polypeptide binding]; other site
355276007965	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
355276007966	DNA binding site [nucleotide binding]
355276007967	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
355276007968	aromatic arch; other site
355276007969	DCoH dimer interaction site [polypeptide binding]; other site
355276007970	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
355276007971	DCoH tetramer interaction site [polypeptide binding]; other site
355276007972	substrate binding site [chemical binding]; other site
355276007973	phosphodiesterase; Provisional; Region: PRK12704
355276007974	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
355276007975	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
355276007976	pyruvate kinase; Provisional; Region: PRK05826
355276007977	domain interfaces; other site
355276007978	active site
355276007979	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
355276007980	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
355276007981	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
355276007982	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
355276007983	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954