-- dump date 20140619_131218 -- class Genbank::misc_feature -- table misc_feature_note -- id note 267671000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 267671000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 267671000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671000004 Walker A motif; other site 267671000005 ATP binding site [chemical binding]; other site 267671000006 Walker B motif; other site 267671000007 arginine finger; other site 267671000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 267671000009 DnaA box-binding interface [nucleotide binding]; other site 267671000010 DNA polymerase III subunit beta; Provisional; Region: PRK14942 267671000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 267671000012 putative DNA binding surface [nucleotide binding]; other site 267671000013 dimer interface [polypeptide binding]; other site 267671000014 beta-clamp/clamp loader binding surface; other site 267671000015 beta-clamp/translesion DNA polymerase binding surface; other site 267671000016 recombination protein F; Reviewed; Region: recF; PRK00064 267671000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671000018 Walker A/P-loop; other site 267671000019 ATP binding site [chemical binding]; other site 267671000020 Q-loop/lid; other site 267671000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671000022 ABC transporter signature motif; other site 267671000023 Walker B; other site 267671000024 D-loop; other site 267671000025 H-loop/switch region; other site 267671000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 267671000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 267671000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671000029 Mg2+ binding site [ion binding]; other site 267671000030 G-X-G motif; other site 267671000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 267671000032 anchoring element; other site 267671000033 dimer interface [polypeptide binding]; other site 267671000034 ATP binding site [chemical binding]; other site 267671000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 267671000036 active site 267671000037 putative metal-binding site [ion binding]; other site 267671000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 267671000039 DNA gyrase subunit A; Validated; Region: PRK05560 267671000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 267671000041 CAP-like domain; other site 267671000042 active site 267671000043 primary dimer interface [polypeptide binding]; other site 267671000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267671000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267671000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267671000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267671000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 267671000049 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 267671000050 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 267671000051 FMN binding site [chemical binding]; other site 267671000052 active site 267671000053 catalytic residues [active] 267671000054 substrate binding site [chemical binding]; other site 267671000055 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 267671000056 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 267671000057 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 267671000058 active site 267671000059 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 267671000060 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 267671000061 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 267671000062 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 267671000063 Maf-like protein; Reviewed; Region: PRK00078 267671000064 active site 267671000065 dimer interface [polypeptide binding]; other site 267671000066 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 267671000067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671000068 NAD(P) binding site [chemical binding]; other site 267671000069 active site 267671000070 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 267671000071 Family description; Region: VCBS; pfam13517 267671000072 FG-GAP repeat; Region: FG-GAP; pfam01839 267671000073 Family description; Region: VCBS; pfam13517 267671000074 Family description; Region: VCBS; pfam13517 267671000075 Family description; Region: VCBS; pfam13517 267671000076 Family description; Region: VCBS; pfam13517 267671000077 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 267671000078 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 267671000079 putative ArsC-like catalytic residues; other site 267671000080 putative TRX-like catalytic residues [active] 267671000081 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 267671000082 FliG C-terminal domain; Region: FliG_C; pfam01706 267671000083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671000084 cyclase homology domain; Region: CHD; cd07302 267671000085 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671000086 nucleotidyl binding site; other site 267671000087 metal binding site [ion binding]; metal-binding site 267671000088 dimer interface [polypeptide binding]; other site 267671000089 hypothetical protein; Provisional; Region: PRK08444 267671000090 Protein of unknown function (DUF989); Region: DUF989; pfam06181 267671000091 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 267671000092 Cytochrome c; Region: Cytochrom_C; pfam00034 267671000093 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 267671000094 active site 267671000095 dimerization interface [polypeptide binding]; other site 267671000096 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 267671000097 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 267671000098 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 267671000099 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 267671000100 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 267671000101 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 267671000102 dimerization interface [polypeptide binding]; other site 267671000103 domain crossover interface; other site 267671000104 redox-dependent activation switch; other site 267671000105 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 267671000106 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 267671000107 Glycoprotease family; Region: Peptidase_M22; pfam00814 267671000108 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 267671000109 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671000110 RNB domain; Region: RNB; pfam00773 267671000111 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671000112 RNA binding site [nucleotide binding]; other site 267671000113 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 267671000114 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 267671000115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000116 binding surface 267671000117 TPR repeat; Region: TPR_11; pfam13414 267671000118 TPR motif; other site 267671000119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000120 binding surface 267671000121 TPR motif; other site 267671000122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671000123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000124 binding surface 267671000125 TPR motif; other site 267671000126 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 267671000127 active site 267671000128 catalytic residue [active] 267671000129 dimer interface [polypeptide binding]; other site 267671000130 KpsF/GutQ family protein; Region: kpsF; TIGR00393 267671000131 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 267671000132 putative active site [active] 267671000133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 267671000134 transcriptional activator RfaH; Region: RfaH; TIGR01955 267671000135 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 267671000136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671000137 PAS domain; Region: PAS_9; pfam13426 267671000138 putative active site [active] 267671000139 heme pocket [chemical binding]; other site 267671000140 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671000141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671000142 dimer interface [polypeptide binding]; other site 267671000143 putative CheW interface [polypeptide binding]; other site 267671000144 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 267671000145 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 267671000146 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 267671000147 NAD binding site [chemical binding]; other site 267671000148 putative substrate binding site 2 [chemical binding]; other site 267671000149 putative substrate binding site 1 [chemical binding]; other site 267671000150 active site 267671000151 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 267671000152 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 267671000153 ligand binding site [chemical binding]; other site 267671000154 homodimer interface [polypeptide binding]; other site 267671000155 NAD(P) binding site [chemical binding]; other site 267671000156 trimer interface B [polypeptide binding]; other site 267671000157 trimer interface A [polypeptide binding]; other site 267671000158 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 267671000159 active site 267671000160 histidyl-tRNA synthetase; Region: hisS; TIGR00442 267671000161 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 267671000162 dimer interface [polypeptide binding]; other site 267671000163 motif 1; other site 267671000164 active site 267671000165 motif 2; other site 267671000166 motif 3; other site 267671000167 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 267671000168 anticodon binding site; other site 267671000169 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 267671000170 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 267671000171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 267671000172 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671000173 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 267671000174 ligand binding site [chemical binding]; other site 267671000175 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 267671000176 dihydropteroate synthase; Region: DHPS; TIGR01496 267671000177 substrate binding pocket [chemical binding]; other site 267671000178 dimer interface [polypeptide binding]; other site 267671000179 inhibitor binding site; inhibition site 267671000180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000181 binding surface 267671000182 TPR motif; other site 267671000183 TPR repeat; Region: TPR_11; pfam13414 267671000184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000185 binding surface 267671000186 TPR motif; other site 267671000187 TPR repeat; Region: TPR_11; pfam13414 267671000188 TPR repeat; Region: TPR_11; pfam13414 267671000189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000190 TPR motif; other site 267671000191 binding surface 267671000192 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 267671000193 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 267671000194 Sporulation related domain; Region: SPOR; pfam05036 267671000195 serine O-acetyltransferase; Region: cysE; TIGR01172 267671000196 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 267671000197 trimer interface [polypeptide binding]; other site 267671000198 active site 267671000199 substrate binding site [chemical binding]; other site 267671000200 CoA binding site [chemical binding]; other site 267671000201 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 267671000202 Peptidase family M50; Region: Peptidase_M50; pfam02163 267671000203 active site 267671000204 putative substrate binding region [chemical binding]; other site 267671000205 Uncharacterized conserved protein [Function unknown]; Region: COG3391 267671000206 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 267671000207 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 267671000208 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 267671000209 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 267671000210 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 267671000211 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671000212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671000213 dimerization interface [polypeptide binding]; other site 267671000214 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671000215 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671000216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000217 binding surface 267671000218 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671000219 TPR motif; other site 267671000220 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 267671000221 Zn binding site [ion binding]; other site 267671000222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671000223 putative substrate translocation pore; other site 267671000224 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671000225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671000226 dimerization interface [polypeptide binding]; other site 267671000227 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671000228 TPR repeat; Region: TPR_11; pfam13414 267671000229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000230 binding surface 267671000231 TPR motif; other site 267671000232 TPR repeat; Region: TPR_11; pfam13414 267671000233 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 267671000234 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 267671000235 trimer interface [polypeptide binding]; other site 267671000236 active site 267671000237 enoyl-CoA hydratase; Provisional; Region: PRK07657 267671000238 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671000239 substrate binding site [chemical binding]; other site 267671000240 oxyanion hole (OAH) forming residues; other site 267671000241 trimer interface [polypeptide binding]; other site 267671000242 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 267671000243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671000244 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 267671000245 active site 267671000246 metal binding site [ion binding]; metal-binding site 267671000247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671000248 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 267671000249 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 267671000250 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 267671000251 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671000252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671000253 S-adenosylmethionine binding site [chemical binding]; other site 267671000254 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 267671000255 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 267671000256 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 267671000257 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267671000258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 267671000259 putative acyl-acceptor binding pocket; other site 267671000260 Uncharacterized conserved protein [Function unknown]; Region: COG5439 267671000261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 267671000262 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 267671000263 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 267671000264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671000265 S-adenosylmethionine binding site [chemical binding]; other site 267671000266 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 267671000267 catalytic triad [active] 267671000268 HEAT repeats; Region: HEAT_2; pfam13646 267671000269 HEAT repeats; Region: HEAT_2; pfam13646 267671000270 HEAT repeats; Region: HEAT_2; pfam13646 267671000271 HEAT repeats; Region: HEAT_2; pfam13646 267671000272 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 267671000273 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 267671000274 acyl-activating enzyme (AAE) consensus motif; other site 267671000275 CoA binding site [chemical binding]; other site 267671000276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 267671000277 AMP binding site [chemical binding]; other site 267671000278 active site 267671000279 CoA binding site [chemical binding]; other site 267671000280 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 267671000281 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 267671000282 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 267671000283 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 267671000284 aminodeoxychorismate synthase; Provisional; Region: PRK07508 267671000285 chorismate binding enzyme; Region: Chorismate_bind; cl10555 267671000286 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 267671000287 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 267671000288 substrate-cofactor binding pocket; other site 267671000289 homodimer interface [polypeptide binding]; other site 267671000290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671000291 catalytic residue [active] 267671000292 MASE1; Region: MASE1; pfam05231 267671000293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267671000294 Histidine kinase; Region: HisKA_2; pfam07568 267671000295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671000296 ATP binding site [chemical binding]; other site 267671000297 Mg2+ binding site [ion binding]; other site 267671000298 G-X-G motif; other site 267671000299 Protein of unknown function (DUF1567); Region: DUF1567; pfam07604 267671000300 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267671000301 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 267671000302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671000303 catalytic residue [active] 267671000304 peptide chain release factor 1; Validated; Region: prfA; PRK00591 267671000305 PCRF domain; Region: PCRF; pfam03462 267671000306 RF-1 domain; Region: RF-1; pfam00472 267671000307 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 267671000308 active site 267671000309 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 267671000310 nudix motif; other site 267671000311 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 267671000312 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 267671000313 putative active site pocket [active] 267671000314 4-fold oligomerization interface [polypeptide binding]; other site 267671000315 metal binding residues [ion binding]; metal-binding site 267671000316 3-fold/trimer interface [polypeptide binding]; other site 267671000317 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK14004 267671000318 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 267671000319 putative active site [active] 267671000320 oxyanion strand; other site 267671000321 catalytic triad [active] 267671000322 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 267671000323 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 267671000324 catalytic residues [active] 267671000325 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 267671000326 putative active site [active] 267671000327 redox center [active] 267671000328 Thioredoxin; Region: Thioredoxin_4; pfam13462 267671000329 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 267671000330 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 267671000331 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 267671000332 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 267671000333 dimer interface [polypeptide binding]; other site 267671000334 substrate binding site [chemical binding]; other site 267671000335 ATP binding site [chemical binding]; other site 267671000336 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 267671000337 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 267671000338 DNA binding site [nucleotide binding] 267671000339 active site 267671000340 GAF domain; Region: GAF_3; pfam13492 267671000341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671000342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671000343 ATP binding site [chemical binding]; other site 267671000344 Mg2+ binding site [ion binding]; other site 267671000345 G-X-G motif; other site 267671000346 GTPase RsgA; Reviewed; Region: PRK00098 267671000347 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671000348 RNA binding site [nucleotide binding]; other site 267671000349 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 267671000350 GTPase/Zn-binding domain interface [polypeptide binding]; other site 267671000351 GTP/Mg2+ binding site [chemical binding]; other site 267671000352 G4 box; other site 267671000353 G5 box; other site 267671000354 G1 box; other site 267671000355 Switch I region; other site 267671000356 G2 box; other site 267671000357 G3 box; other site 267671000358 Switch II region; other site 267671000359 FecR protein; Region: FecR; pfam04773 267671000360 PEGA domain; Region: PEGA; pfam08308 267671000361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000362 binding surface 267671000363 TPR motif; other site 267671000364 TPR repeat; Region: TPR_11; pfam13414 267671000365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000366 binding surface 267671000367 TPR motif; other site 267671000368 TPR repeat; Region: TPR_11; pfam13414 267671000369 TPR repeat; Region: TPR_11; pfam13414 267671000370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000371 TPR motif; other site 267671000372 binding surface 267671000373 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671000374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000375 binding surface 267671000376 TPR motif; other site 267671000377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000378 binding surface 267671000379 TPR motif; other site 267671000380 TPR repeat; Region: TPR_11; pfam13414 267671000381 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 267671000382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000383 TPR motif; other site 267671000384 binding surface 267671000385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000386 binding surface 267671000387 TPR motif; other site 267671000388 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 267671000389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671000390 S-adenosylmethionine binding site [chemical binding]; other site 267671000391 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 267671000392 PilZ domain; Region: PilZ; pfam07238 267671000393 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 267671000394 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 267671000395 G1 box; other site 267671000396 GTP/Mg2+ binding site [chemical binding]; other site 267671000397 Switch I region; other site 267671000398 G2 box; other site 267671000399 G3 box; other site 267671000400 Switch II region; other site 267671000401 G4 box; other site 267671000402 G5 box; other site 267671000403 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 267671000404 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 267671000405 Ligand Binding Site [chemical binding]; other site 267671000406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671000407 GAF domain; Region: GAF; pfam01590 267671000408 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 267671000409 GAF domain; Region: GAF; pfam01590 267671000410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671000411 Walker A motif; other site 267671000412 ATP binding site [chemical binding]; other site 267671000413 Walker B motif; other site 267671000414 arginine finger; other site 267671000415 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 267671000416 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 267671000417 SET domain; Region: SET; pfam00856 267671000418 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267671000419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 267671000420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671000421 Walker A/P-loop; other site 267671000422 ATP binding site [chemical binding]; other site 267671000423 Q-loop/lid; other site 267671000424 ABC transporter signature motif; other site 267671000425 Walker B; other site 267671000426 D-loop; other site 267671000427 H-loop/switch region; other site 267671000428 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 267671000429 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 267671000430 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 267671000431 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 267671000432 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 267671000433 Tetramer interface [polypeptide binding]; other site 267671000434 active site 267671000435 FMN-binding site [chemical binding]; other site 267671000436 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 267671000437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 267671000438 catalytic loop [active] 267671000439 iron binding site [ion binding]; other site 267671000440 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 267671000441 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 267671000442 Molybdopterin oxidoreductase; Region: Molybdopterin; pfam00384 267671000443 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 267671000444 4Fe-4S binding domain; Region: Fer4; pfam00037 267671000445 Protein of unknown function (DUF433); Region: DUF433; pfam04255 267671000446 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 267671000447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671000448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671000449 DNA binding residues [nucleotide binding] 267671000450 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 267671000451 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 267671000452 catalytic residues [active] 267671000453 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 267671000454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671000455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671000456 homodimer interface [polypeptide binding]; other site 267671000457 catalytic residue [active] 267671000458 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 267671000459 hypothetical protein; Provisional; Region: PRK14391 267671000460 membrane protein insertase; Provisional; Region: PRK01318 267671000461 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 267671000462 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 267671000463 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 267671000464 G-X-X-G motif; other site 267671000465 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 267671000466 RxxxH motif; other site 267671000467 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 267671000468 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 267671000469 trmE is a tRNA modification GTPase; Region: trmE; cd04164 267671000470 G1 box; other site 267671000471 GTP/Mg2+ binding site [chemical binding]; other site 267671000472 Switch I region; other site 267671000473 G2 box; other site 267671000474 Switch II region; other site 267671000475 G3 box; other site 267671000476 G4 box; other site 267671000477 G5 box; other site 267671000478 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 267671000479 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 267671000480 Malic enzyme, N-terminal domain; Region: malic; pfam00390 267671000481 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 267671000482 putative NAD(P) binding site [chemical binding]; other site 267671000483 fumarate hydratase; Reviewed; Region: fumC; PRK00485 267671000484 Class II fumarases; Region: Fumarase_classII; cd01362 267671000485 active site 267671000486 tetramer interface [polypeptide binding]; other site 267671000487 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 267671000488 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 267671000489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671000490 non-specific DNA binding site [nucleotide binding]; other site 267671000491 salt bridge; other site 267671000492 sequence-specific DNA binding site [nucleotide binding]; other site 267671000493 Helix-turn-helix domain; Region: HTH_17; pfam12728 267671000494 Phage Tail Protein X; Region: Phage_tail_X; cl02088 267671000495 Protein of unknown function (DUF1562); Region: DUF1562; pfam07601 267671000496 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 267671000497 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671000498 ligand binding site [chemical binding]; other site 267671000499 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 267671000500 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267671000501 RNA binding surface [nucleotide binding]; other site 267671000502 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 267671000503 active site 267671000504 Predicted amidohydrolase [General function prediction only]; Region: COG0388 267671000505 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 267671000506 putative active site [active] 267671000507 catalytic triad [active] 267671000508 putative dimer interface [polypeptide binding]; other site 267671000509 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 267671000510 classical (c) SDRs; Region: SDR_c; cd05233 267671000511 NAD(P) binding site [chemical binding]; other site 267671000512 active site 267671000513 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 267671000514 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 267671000515 Uncharacterized conserved protein [Function unknown]; Region: COG3339 267671000516 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 267671000517 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 267671000518 active site 267671000519 dimerization interface [polypeptide binding]; other site 267671000520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671000521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 267671000522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671000523 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 267671000524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671000525 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 267671000526 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 267671000527 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 267671000528 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 267671000529 NADP-binding site; other site 267671000530 homotetramer interface [polypeptide binding]; other site 267671000531 substrate binding site [chemical binding]; other site 267671000532 homodimer interface [polypeptide binding]; other site 267671000533 active site 267671000534 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 267671000535 UbiA prenyltransferase family; Region: UbiA; pfam01040 267671000536 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 267671000537 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 267671000538 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 267671000539 Cu(I) binding site [ion binding]; other site 267671000540 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 267671000541 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 267671000542 Cytochrome c; Region: Cytochrom_C; pfam00034 267671000543 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 267671000544 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 267671000545 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 267671000546 Subunit I/III interface [polypeptide binding]; other site 267671000547 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 267671000548 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 267671000549 putative active site [active] 267671000550 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 267671000551 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 267671000552 active site 267671000553 substrate-binding site [chemical binding]; other site 267671000554 metal-binding site [ion binding] 267671000555 ATP binding site [chemical binding]; other site 267671000556 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 267671000557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 267671000558 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 267671000559 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671000560 P-loop; other site 267671000561 Magnesium ion binding site [ion binding]; other site 267671000562 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671000563 Magnesium ion binding site [ion binding]; other site 267671000564 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 267671000565 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 267671000566 GatB domain; Region: GatB_Yqey; smart00845 267671000567 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 267671000568 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 267671000569 active site 267671000570 PHP Thumb interface [polypeptide binding]; other site 267671000571 metal binding site [ion binding]; metal-binding site 267671000572 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 267671000573 generic binding surface I; other site 267671000574 generic binding surface II; other site 267671000575 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671000576 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671000577 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671000578 CHAT domain; Region: CHAT; pfam12770 267671000579 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 267671000580 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 267671000581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267671000582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 267671000583 Walker A/P-loop; other site 267671000584 ATP binding site [chemical binding]; other site 267671000585 Q-loop/lid; other site 267671000586 ABC transporter signature motif; other site 267671000587 Walker B; other site 267671000588 D-loop; other site 267671000589 H-loop/switch region; other site 267671000590 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 267671000591 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671000592 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671000593 ligand binding site [chemical binding]; other site 267671000594 flexible hinge region; other site 267671000595 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671000596 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 267671000597 ligand binding site [chemical binding]; other site 267671000598 flexible hinge region; other site 267671000599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 267671000600 endonuclease III; Region: ENDO3c; smart00478 267671000601 minor groove reading motif; other site 267671000602 helix-hairpin-helix signature motif; other site 267671000603 substrate binding pocket [chemical binding]; other site 267671000604 active site 267671000605 Beta-propeller repeat; Region: SBBP; pfam06739 267671000606 Beta-propeller repeat; Region: SBBP; pfam06739 267671000607 Beta-propeller repeat; Region: SBBP; pfam06739 267671000608 Beta-propeller repeat; Region: SBBP; pfam06739 267671000609 Beta-propeller repeat; Region: SBBP; pfam06739 267671000610 Beta-propeller repeat; Region: SBBP; pfam06739 267671000611 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 267671000612 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671000613 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671000614 cyclase homology domain; Region: CHD; cd07302 267671000615 nucleotidyl binding site; other site 267671000616 metal binding site [ion binding]; metal-binding site 267671000617 dimer interface [polypeptide binding]; other site 267671000618 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671000619 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671000620 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 267671000621 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 267671000622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671000623 S-adenosylmethionine binding site [chemical binding]; other site 267671000624 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 267671000625 AAA domain; Region: AAA_23; pfam13476 267671000626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671000627 ABC transporter signature motif; other site 267671000628 Walker B; other site 267671000629 D-loop; other site 267671000630 H-loop/switch region; other site 267671000631 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 267671000632 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 267671000633 active site 267671000634 metal binding site [ion binding]; metal-binding site 267671000635 DNA binding site [nucleotide binding] 267671000636 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 267671000637 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 267671000638 putative NAD(P) binding site [chemical binding]; other site 267671000639 FOG: CBS domain [General function prediction only]; Region: COG0517 267671000640 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803 267671000641 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 267671000642 HSP70 interaction site [polypeptide binding]; other site 267671000643 Carbon starvation protein CstA; Region: CstA; pfam02554 267671000644 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 267671000645 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 267671000646 Carbon starvation protein CstA; Region: CstA; pfam02554 267671000647 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 267671000648 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 267671000649 nudix motif; other site 267671000650 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 267671000651 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671000652 ligand binding site [chemical binding]; other site 267671000653 NRDE protein; Region: NRDE; cl01315 267671000654 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 267671000655 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671000656 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671000657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671000658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671000659 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671000660 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 267671000661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671000662 S-adenosylmethionine binding site [chemical binding]; other site 267671000663 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671000664 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 267671000665 ligand binding site [chemical binding]; other site 267671000666 flexible hinge region; other site 267671000667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671000668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671000669 ligand binding site [chemical binding]; other site 267671000670 flexible hinge region; other site 267671000671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671000672 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 267671000673 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 267671000674 active site 267671000675 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 267671000676 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671000677 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 267671000678 elongation factor G; Reviewed; Region: PRK12740 267671000679 G1 box; other site 267671000680 putative GEF interaction site [polypeptide binding]; other site 267671000681 GTP/Mg2+ binding site [chemical binding]; other site 267671000682 Switch I region; other site 267671000683 G2 box; other site 267671000684 G3 box; other site 267671000685 Switch II region; other site 267671000686 G4 box; other site 267671000687 G5 box; other site 267671000688 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 267671000689 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 267671000690 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 267671000691 Cation transport protein; Region: TrkH; cl17365 267671000692 Cation transport protein; Region: TrkH; cl17365 267671000693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671000694 non-specific DNA binding site [nucleotide binding]; other site 267671000695 salt bridge; other site 267671000696 sequence-specific DNA binding site [nucleotide binding]; other site 267671000697 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 267671000698 UbiA prenyltransferase family; Region: UbiA; pfam01040 267671000699 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 267671000700 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 267671000701 catalytic residues [active] 267671000702 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 267671000703 putative hydrophobic ligand binding site [chemical binding]; other site 267671000704 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 267671000705 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 267671000706 putative NAD(P) binding site [chemical binding]; other site 267671000707 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 267671000708 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 267671000709 substrate binding pocket [chemical binding]; other site 267671000710 chain length determination region; other site 267671000711 substrate-Mg2+ binding site; other site 267671000712 catalytic residues [active] 267671000713 aspartate-rich region 1; other site 267671000714 active site lid residues [active] 267671000715 aspartate-rich region 2; other site 267671000716 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 267671000717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267671000718 RNA binding surface [nucleotide binding]; other site 267671000719 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 267671000720 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 267671000721 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 267671000722 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 267671000723 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 267671000724 active site 267671000725 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 267671000726 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 267671000727 active site 267671000728 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 267671000729 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 267671000730 Ligand Binding Site [chemical binding]; other site 267671000731 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 267671000732 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 267671000733 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 267671000734 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 267671000735 active site 267671000736 catalytic site [active] 267671000737 metal binding site [ion binding]; metal-binding site 267671000738 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 267671000739 Uncharacterized conserved protein [Function unknown]; Region: COG3791 267671000740 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12729 267671000741 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 267671000742 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 267671000743 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 267671000744 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624 267671000745 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671000746 anti sigma factor interaction site; other site 267671000747 regulatory phosphorylation site [posttranslational modification]; other site 267671000748 TPR repeat; Region: TPR_11; pfam13414 267671000749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000750 binding surface 267671000751 TPR motif; other site 267671000752 TPR repeat; Region: TPR_11; pfam13414 267671000753 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 267671000754 Protein of unknown function (DUF454); Region: DUF454; pfam04304 267671000755 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 267671000756 glycine dehydrogenase; Provisional; Region: PRK05367 267671000757 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 267671000758 tetramer interface [polypeptide binding]; other site 267671000759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671000760 catalytic residue [active] 267671000761 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 267671000762 tetramer interface [polypeptide binding]; other site 267671000763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671000764 catalytic residue [active] 267671000765 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 267671000766 lipoyl attachment site [posttranslational modification]; other site 267671000767 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 267671000768 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 267671000769 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 267671000770 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 267671000771 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 267671000772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671000773 catalytic residue [active] 267671000774 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 267671000775 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 267671000776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000777 binding surface 267671000778 TPR motif; other site 267671000779 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671000780 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 267671000781 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 267671000782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000783 binding surface 267671000784 TPR motif; other site 267671000785 TPR repeat; Region: TPR_11; pfam13414 267671000786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000787 binding surface 267671000788 TPR motif; other site 267671000789 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671000790 Methyltransferase domain; Region: Methyltransf_18; pfam12847 267671000791 KWG Leptospira; Region: KWG; pfam07656 267671000792 KWG Leptospira; Region: KWG; pfam07656 267671000793 KWG Leptospira; Region: KWG; pfam07656 267671000794 Bacterial sugar transferase; Region: Bac_transf; pfam02397 267671000795 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 267671000796 dinuclear metal binding motif [ion binding]; other site 267671000797 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671000798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671000799 active site 267671000800 phosphorylation site [posttranslational modification] 267671000801 intermolecular recognition site; other site 267671000802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 267671000803 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 267671000804 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 267671000805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671000806 FeS/SAM binding site; other site 267671000807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000808 binding surface 267671000809 TPR motif; other site 267671000810 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 267671000811 Clp amino terminal domain; Region: Clp_N; pfam02861 267671000812 Clp amino terminal domain; Region: Clp_N; pfam02861 267671000813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671000814 Walker A motif; other site 267671000815 ATP binding site [chemical binding]; other site 267671000816 Walker B motif; other site 267671000817 arginine finger; other site 267671000818 UvrB/uvrC motif; Region: UVR; pfam02151 267671000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671000820 Walker A motif; other site 267671000821 ATP binding site [chemical binding]; other site 267671000822 Walker B motif; other site 267671000823 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 267671000824 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 267671000825 phosphagen binding site; other site 267671000826 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 267671000827 catalytic residues [active] 267671000828 Int/Topo IB signature motif; other site 267671000829 DNA binding site [nucleotide binding] 267671000830 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671000831 anti sigma factor interaction site; other site 267671000832 regulatory phosphorylation site [posttranslational modification]; other site 267671000833 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 267671000834 active site 267671000835 catalytic triad [active] 267671000836 oxyanion hole [active] 267671000837 Arylesterase; Region: Arylesterase; pfam01731 267671000838 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267671000839 catalytic core [active] 267671000840 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267671000841 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 267671000842 Walker A/P-loop; other site 267671000843 ATP binding site [chemical binding]; other site 267671000844 Q-loop/lid; other site 267671000845 ABC transporter signature motif; other site 267671000846 Walker B; other site 267671000847 D-loop; other site 267671000848 H-loop/switch region; other site 267671000849 HDOD domain; Region: HDOD; pfam08668 267671000850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671000851 Zn2+ binding site [ion binding]; other site 267671000852 Mg2+ binding site [ion binding]; other site 267671000853 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 267671000854 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 267671000855 Competence protein; Region: Competence; pfam03772 267671000856 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 267671000857 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 267671000858 active site 267671000859 HIGH motif; other site 267671000860 dimer interface [polypeptide binding]; other site 267671000861 KMSKS motif; other site 267671000862 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 267671000863 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 267671000864 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 267671000865 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 267671000866 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 267671000867 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 267671000868 Ligand binding site [chemical binding]; other site 267671000869 Electron transfer flavoprotein domain; Region: ETF; pfam01012 267671000870 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 267671000871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671000872 active site 267671000873 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 267671000874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671000875 S-adenosylmethionine binding site [chemical binding]; other site 267671000876 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 267671000877 Putative Ig domain; Region: He_PIG; pfam05345 267671000878 Putative Ig domain; Region: He_PIG; pfam05345 267671000879 Beta-propeller repeat; Region: SBBP; pfam06739 267671000880 Beta-propeller repeat; Region: SBBP; pfam06739 267671000881 Beta-propeller repeat; Region: SBBP; pfam06739 267671000882 Beta-propeller repeat; Region: SBBP; pfam06739 267671000883 Beta-propeller repeat; Region: SBBP; pfam06739 267671000884 Beta-propeller repeat; Region: SBBP; pfam06739 267671000885 Beta-propeller repeat; Region: SBBP; pfam06739 267671000886 Beta-propeller repeat; Region: SBBP; pfam06739 267671000887 Beta-propeller repeat; Region: SBBP; pfam06739 267671000888 Beta-propeller repeat; Region: SBBP; pfam06739 267671000889 Beta-propeller repeat; Region: SBBP; pfam06739 267671000890 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 267671000891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671000893 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671000894 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 267671000895 Predicted transcriptional regulators [Transcription]; Region: COG1695 267671000896 Transcriptional regulator PadR-like family; Region: PadR; cl17335 267671000897 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 267671000898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671000899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671000900 active site 267671000901 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 267671000902 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 267671000903 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671000904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671000905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671000906 DNA binding residues [nucleotide binding] 267671000907 FecR protein; Region: FecR; pfam04773 267671000908 DoxX; Region: DoxX; pfam07681 267671000909 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267671000910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671000911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671000912 ABC transporter; Region: ABC_tran_2; pfam12848 267671000913 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671000914 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 267671000915 active site residue [active] 267671000916 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 267671000917 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 267671000918 putative active site [active] 267671000919 putative metal binding site [ion binding]; other site 267671000920 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671000921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671000922 WHG domain; Region: WHG; pfam13305 267671000923 putative acyltransferase; Provisional; Region: PRK05790 267671000924 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 267671000925 dimer interface [polypeptide binding]; other site 267671000926 active site 267671000927 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 267671000928 amidase catalytic site [active] 267671000929 Zn binding residues [ion binding]; other site 267671000930 substrate binding site [chemical binding]; other site 267671000931 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 267671000932 amidase catalytic site [active] 267671000933 Zn binding residues [ion binding]; other site 267671000934 substrate binding site [chemical binding]; other site 267671000935 chromosome segregation protein; Provisional; Region: PRK03918 267671000936 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 267671000937 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 267671000938 homopentamer interface [polypeptide binding]; other site 267671000939 active site 267671000940 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 267671000941 TPR repeat; Region: TPR_11; pfam13414 267671000942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000943 TPR motif; other site 267671000944 binding surface 267671000945 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 267671000946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000947 binding surface 267671000948 TPR motif; other site 267671000949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000950 binding surface 267671000951 TPR motif; other site 267671000952 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 267671000953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671000954 binding surface 267671000955 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 267671000956 HEAT repeats; Region: HEAT_2; pfam13646 267671000957 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671000958 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 267671000959 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 267671000960 active site 267671000961 catalytic residues [active] 267671000962 metal binding site [ion binding]; metal-binding site 267671000963 HEAT repeats; Region: HEAT_2; pfam13646 267671000964 Predicted permeases [General function prediction only]; Region: COG0795 267671000965 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 267671000966 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 267671000967 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 267671000968 NAD(P) binding site [chemical binding]; other site 267671000969 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 267671000970 WYL domain; Region: WYL; pfam13280 267671000971 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 267671000972 Part of AAA domain; Region: AAA_19; pfam13245 267671000973 Family description; Region: UvrD_C_2; pfam13538 267671000974 Predicted transcriptional regulator [Transcription]; Region: COG2378 267671000975 WYL domain; Region: WYL; pfam13280 267671000976 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14613 267671000977 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 267671000978 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 267671000979 Substrate binding site; other site 267671000980 Mg++ binding site; other site 267671000981 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 267671000982 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 267671000983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 267671000984 active site 267671000985 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 267671000986 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 267671000987 5S rRNA interface [nucleotide binding]; other site 267671000988 CTC domain interface [polypeptide binding]; other site 267671000989 L16 interface [polypeptide binding]; other site 267671000990 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 267671000991 putative active site [active] 267671000992 catalytic residue [active] 267671000993 FtsH Extracellular; Region: FtsH_ext; pfam06480 267671000994 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 267671000995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671000996 Walker A motif; other site 267671000997 ATP binding site [chemical binding]; other site 267671000998 Walker B motif; other site 267671000999 arginine finger; other site 267671001000 Peptidase family M41; Region: Peptidase_M41; pfam01434 267671001001 EVE domain; Region: EVE; cl00728 267671001002 Cytochrome C' Region: Cytochrom_C_2; cl01610 267671001003 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 267671001004 spermidine synthase; Provisional; Region: PRK03612 267671001005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671001006 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 267671001007 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 267671001008 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 267671001009 Nitrogen regulatory protein P-II; Region: P-II; smart00938 267671001010 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 267671001011 Protein of unknown function (DUF1567); Region: DUF1567; pfam07604 267671001012 Protein of unknown function (DUF1567); Region: DUF1567; pfam07604 267671001013 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 267671001014 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 267671001015 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 267671001016 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 267671001017 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 267671001018 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 267671001019 glutaminase active site [active] 267671001020 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 267671001021 dimer interface [polypeptide binding]; other site 267671001022 active site 267671001023 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 267671001024 dimer interface [polypeptide binding]; other site 267671001025 active site 267671001026 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 267671001027 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 267671001028 active site 267671001029 substrate binding site [chemical binding]; other site 267671001030 metal binding site [ion binding]; metal-binding site 267671001031 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 267671001032 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 267671001033 Ligand binding site; other site 267671001034 Putative Catalytic site; other site 267671001035 DXD motif; other site 267671001036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 267671001037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671001038 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 267671001039 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 267671001040 active site 267671001041 purine riboside binding site [chemical binding]; other site 267671001042 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671001043 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 267671001044 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001045 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001046 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001047 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001048 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001049 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001050 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001051 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001052 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001053 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001054 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001055 Bacterial Ig-like domain 2; Region: BID_2; smart00635 267671001056 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001057 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001058 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 267671001059 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 267671001060 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 267671001061 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 267671001062 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 267671001063 peptide chain release factor 2; Validated; Region: prfB; PRK00578 267671001064 PCRF domain; Region: PCRF; pfam03462 267671001065 RF-1 domain; Region: RF-1; pfam00472 267671001066 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13789 267671001067 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 267671001068 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 267671001069 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 267671001070 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 267671001071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267671001072 active site 267671001073 HIGH motif; other site 267671001074 nucleotide binding site [chemical binding]; other site 267671001075 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 267671001076 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 267671001077 active site 267671001078 KMSKS motif; other site 267671001079 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 267671001080 tRNA binding surface [nucleotide binding]; other site 267671001081 anticodon binding site; other site 267671001082 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 267671001083 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 267671001084 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 267671001085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 267671001086 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 267671001087 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 267671001088 Catalytic site [active] 267671001089 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 267671001090 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 267671001091 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 267671001092 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 267671001093 Short C-terminal domain; Region: SHOCT; pfam09851 267671001094 threonine synthase; Validated; Region: PRK06260 267671001095 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 267671001096 homodimer interface [polypeptide binding]; other site 267671001097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671001098 catalytic residue [active] 267671001099 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 267671001100 MORN repeat; Region: MORN; pfam02493 267671001101 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 267671001102 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 267671001103 Protein export membrane protein; Region: SecD_SecF; cl14618 267671001104 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 267671001105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 267671001106 HlyD family secretion protein; Region: HlyD_3; pfam13437 267671001107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671001108 binding surface 267671001109 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671001110 TPR motif; other site 267671001111 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671001112 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671001113 Outer membrane efflux protein; Region: OEP; pfam02321 267671001114 Outer membrane efflux protein; Region: OEP; pfam02321 267671001115 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 267671001116 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671001117 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671001118 Fn3 associated; Region: Fn3_assoc; pfam13287 267671001119 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671001120 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671001121 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671001122 Putative Ig domain; Region: He_PIG; pfam05345 267671001123 Putative Ig domain; Region: He_PIG; pfam05345 267671001124 Putative Ig domain; Region: He_PIG; pfam05345 267671001125 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 267671001126 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 267671001127 thioester formation/cholesterol transfer; other site 267671001128 protein-splicing catalytic site; other site 267671001129 Integrase core domain; Region: rve; pfam00665 267671001130 Catalytic site; other site 267671001131 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 267671001132 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 267671001133 thioester formation/cholesterol transfer; other site 267671001134 protein-splicing catalytic site; other site 267671001135 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 267671001136 Pretoxin HINT domain; Region: PT-HINT; pfam07591 267671001137 thioester formation/cholesterol transfer; other site 267671001138 protein-splicing catalytic site; other site 267671001139 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 267671001140 putative active site [active] 267671001141 Integrase core domain; Region: rve; pfam00665 267671001142 Integrase core domain; Region: rve_3; pfam13683 267671001143 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 267671001144 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 267671001145 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 267671001146 HIGH motif; other site 267671001147 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 267671001148 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267671001149 active site 267671001150 KMSKS motif; other site 267671001151 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 267671001152 tRNA binding surface [nucleotide binding]; other site 267671001153 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267671001154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 267671001155 Walker A/P-loop; other site 267671001156 ATP binding site [chemical binding]; other site 267671001157 Q-loop/lid; other site 267671001158 ABC transporter signature motif; other site 267671001159 Walker B; other site 267671001160 D-loop; other site 267671001161 H-loop/switch region; other site 267671001162 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 267671001163 FtsX-like permease family; Region: FtsX; pfam02687 267671001164 FtsX-like permease family; Region: FtsX; pfam02687 267671001165 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 267671001166 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267671001167 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 267671001168 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 267671001169 chaperone protein DnaJ; Provisional; Region: PRK14286 267671001170 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 267671001171 HSP70 interaction site [polypeptide binding]; other site 267671001172 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 267671001173 substrate binding site [polypeptide binding]; other site 267671001174 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 267671001175 Zn binding sites [ion binding]; other site 267671001176 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 267671001177 dimer interface [polypeptide binding]; other site 267671001178 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 267671001179 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 267671001180 nucleotide binding site [chemical binding]; other site 267671001181 NEF interaction site [polypeptide binding]; other site 267671001182 SBD interface [polypeptide binding]; other site 267671001183 GrpE; Region: GrpE; pfam01025 267671001184 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 267671001185 dimer interface [polypeptide binding]; other site 267671001186 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 267671001187 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 267671001188 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 267671001189 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 267671001190 Low molecular weight phosphatase family; Region: LMWPc; cl00105 267671001191 active site 267671001192 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 267671001193 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 267671001194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 267671001195 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 267671001196 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 267671001197 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 267671001198 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267671001199 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 267671001200 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 267671001201 Walker A/P-loop; other site 267671001202 ATP binding site [chemical binding]; other site 267671001203 Q-loop/lid; other site 267671001204 ABC transporter signature motif; other site 267671001205 Walker B; other site 267671001206 D-loop; other site 267671001207 H-loop/switch region; other site 267671001208 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 267671001209 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 267671001210 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 267671001211 Transglycosylase; Region: Transgly; pfam00912 267671001212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 267671001213 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 267671001214 Protein of unknown function; Region: DUF3658; pfam12395 267671001215 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 267671001216 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 267671001217 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 267671001218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671001219 ligand binding site [chemical binding]; other site 267671001220 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 267671001221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671001222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671001223 ABC transporter; Region: ABC_tran_2; pfam12848 267671001224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671001225 Pathogenicity locus; Region: Cdd1; pfam11731 267671001226 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 267671001227 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 267671001228 trimer interface [polypeptide binding]; other site 267671001229 active site 267671001230 substrate binding site [chemical binding]; other site 267671001231 CoA binding site [chemical binding]; other site 267671001232 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 267671001233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671001234 FAD binding site [chemical binding]; other site 267671001235 substrate binding site [chemical binding]; other site 267671001236 catalytic residues [active] 267671001237 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 267671001238 methionine sulfoxide reductase A; Provisional; Region: PRK14054 267671001239 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 267671001240 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 267671001241 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 267671001242 Fe-S cluster binding site [ion binding]; other site 267671001243 active site 267671001244 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 267671001245 active site 267671001246 dimerization interface [polypeptide binding]; other site 267671001247 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671001248 anti sigma factor interaction site; other site 267671001249 regulatory phosphorylation site [posttranslational modification]; other site 267671001250 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 267671001251 putative heme binding pocket [chemical binding]; other site 267671001252 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 267671001253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671001254 dimer interface [polypeptide binding]; other site 267671001255 phosphorylation site [posttranslational modification] 267671001256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671001257 ATP binding site [chemical binding]; other site 267671001258 Mg2+ binding site [ion binding]; other site 267671001259 G-X-G motif; other site 267671001260 Response regulator receiver domain; Region: Response_reg; pfam00072 267671001261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671001262 active site 267671001263 phosphorylation site [posttranslational modification] 267671001264 intermolecular recognition site; other site 267671001265 dimerization interface [polypeptide binding]; other site 267671001266 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671001267 SnoaL-like domain; Region: SnoaL_2; pfam12680 267671001268 Response regulator receiver domain; Region: Response_reg; pfam00072 267671001269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671001270 active site 267671001271 phosphorylation site [posttranslational modification] 267671001272 intermolecular recognition site; other site 267671001273 dimerization interface [polypeptide binding]; other site 267671001274 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 267671001275 dimer interface [polypeptide binding]; other site 267671001276 RNA polymerase sigma factor; Provisional; Region: PRK11924 267671001277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671001278 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 267671001279 DNA binding residues [nucleotide binding] 267671001280 YHYH protein; Region: YHYH; pfam14240 267671001281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 267671001282 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 267671001283 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 267671001284 Cu(I) binding site [ion binding]; other site 267671001285 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 267671001286 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 267671001287 dimer interface [polypeptide binding]; other site 267671001288 ssDNA binding site [nucleotide binding]; other site 267671001289 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267671001290 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 267671001291 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671001292 substrate binding site [chemical binding]; other site 267671001293 oxyanion hole (OAH) forming residues; other site 267671001294 trimer interface [polypeptide binding]; other site 267671001295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 267671001296 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671001297 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671001298 anti sigma factor interaction site; other site 267671001299 regulatory phosphorylation site [posttranslational modification]; other site 267671001300 homoserine dehydrogenase; Provisional; Region: PRK06349 267671001301 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 267671001302 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 267671001303 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 267671001304 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 267671001305 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 267671001306 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 267671001307 active site 267671001308 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 267671001309 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 267671001310 HflX GTPase family; Region: HflX; cd01878 267671001311 G1 box; other site 267671001312 GTP/Mg2+ binding site [chemical binding]; other site 267671001313 Switch I region; other site 267671001314 G2 box; other site 267671001315 G3 box; other site 267671001316 Switch II region; other site 267671001317 G4 box; other site 267671001318 G5 box; other site 267671001319 HEAT repeats; Region: HEAT_2; pfam13646 267671001320 HEAT repeats; Region: HEAT_2; pfam13646 267671001321 HEAT repeats; Region: HEAT_2; pfam13646 267671001322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671001323 active site 267671001324 phosphorylation site [posttranslational modification] 267671001325 intermolecular recognition site; other site 267671001326 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267671001327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 267671001328 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 267671001329 Walker A/P-loop; other site 267671001330 ATP binding site [chemical binding]; other site 267671001331 Q-loop/lid; other site 267671001332 ABC transporter signature motif; other site 267671001333 Walker B; other site 267671001334 D-loop; other site 267671001335 H-loop/switch region; other site 267671001336 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 267671001337 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 267671001338 glutamine binding [chemical binding]; other site 267671001339 catalytic triad [active] 267671001340 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 267671001341 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 267671001342 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 267671001343 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671001344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671001345 active site 267671001346 DNA polymerase I; Provisional; Region: PRK05755 267671001347 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 267671001348 active site 267671001349 metal binding site 1 [ion binding]; metal-binding site 267671001350 putative 5' ssDNA interaction site; other site 267671001351 metal binding site 3; metal-binding site 267671001352 metal binding site 2 [ion binding]; metal-binding site 267671001353 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 267671001354 putative DNA binding site [nucleotide binding]; other site 267671001355 putative metal binding site [ion binding]; other site 267671001356 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 267671001357 active site 267671001358 catalytic site [active] 267671001359 substrate binding site [chemical binding]; other site 267671001360 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 267671001361 active site 267671001362 DNA binding site [nucleotide binding] 267671001363 catalytic site [active] 267671001364 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 267671001365 putative ADP-binding pocket [chemical binding]; other site 267671001366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671001367 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 267671001368 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 267671001369 putative active site [active] 267671001370 putative dimer interface [polypeptide binding]; other site 267671001371 ammonium transporter; Region: amt; TIGR00836 267671001372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 267671001373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671001374 dimer interface [polypeptide binding]; other site 267671001375 putative CheW interface [polypeptide binding]; other site 267671001376 Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Region: Pat_hypo_W_succinogenes_WS1459_like; cd07210 267671001377 active site 267671001378 nucleophile elbow; other site 267671001379 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 267671001380 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 267671001381 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671001382 ligand binding site [chemical binding]; other site 267671001383 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671001384 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671001385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001386 binding surface 267671001387 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671001388 TPR motif; other site 267671001389 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 267671001390 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 267671001391 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 267671001392 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671001393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001394 TPR motif; other site 267671001395 binding surface 267671001396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671001397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001398 binding surface 267671001399 TPR motif; other site 267671001400 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 267671001401 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671001402 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671001403 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 267671001404 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 267671001405 active site 267671001406 catalytic site [active] 267671001407 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 267671001408 active site 267671001409 catalytic site [active] 267671001410 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 267671001411 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671001412 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 267671001413 Sulfatase; Region: Sulfatase; pfam00884 267671001414 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 267671001415 hydrophobic ligand binding site; other site 267671001416 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 267671001417 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 267671001418 dimerization interface [polypeptide binding]; other site 267671001419 DPS ferroxidase diiron center [ion binding]; other site 267671001420 ion pore; other site 267671001421 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671001422 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671001423 inhibitor-cofactor binding pocket; inhibition site 267671001424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671001425 catalytic residue [active] 267671001426 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 267671001427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671001428 Walker A motif; other site 267671001429 ATP binding site [chemical binding]; other site 267671001430 Walker B motif; other site 267671001431 arginine finger; other site 267671001432 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 267671001433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001434 TPR motif; other site 267671001435 binding surface 267671001436 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671001437 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 267671001438 homotrimer interaction site [polypeptide binding]; other site 267671001439 zinc binding site [ion binding]; other site 267671001440 CDP-binding sites; other site 267671001441 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 267671001442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 267671001443 Coenzyme A binding pocket [chemical binding]; other site 267671001444 Predicted membrane protein [Function unknown]; Region: COG4270 267671001445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671001446 binding surface 267671001447 TPR motif; other site 267671001448 DNA protecting protein DprA; Region: dprA; TIGR00732 267671001449 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 267671001450 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; pfam05090 267671001451 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 267671001452 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 267671001453 putative active site [active] 267671001454 metal binding site [ion binding]; metal-binding site 267671001455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671001456 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 267671001457 putative ADP-binding pocket [chemical binding]; other site 267671001458 Flagellar protein (FlbD); Region: FlbD; pfam06289 267671001459 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 267671001460 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 267671001461 flagellar motor protein MotB; Validated; Region: motB; PRK06667 267671001462 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 267671001463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671001464 ligand binding site [chemical binding]; other site 267671001465 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 267671001466 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 267671001467 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 267671001468 Ligand binding site; other site 267671001469 oligomer interface; other site 267671001470 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671001471 anti sigma factor interaction site; other site 267671001472 regulatory phosphorylation site [posttranslational modification]; other site 267671001473 Cytochrome c; Region: Cytochrom_C; pfam00034 267671001474 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 267671001475 metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK5_metazoa; cd07793 267671001476 putative N- and C-terminal domain interface [polypeptide binding]; other site 267671001477 putative active site [active] 267671001478 putative MgATP binding site [chemical binding]; other site 267671001479 catalytic site [active] 267671001480 metal binding site [ion binding]; metal-binding site 267671001481 putative homotetramer interface [polypeptide binding]; other site 267671001482 putative homodimer interface [polypeptide binding]; other site 267671001483 putative glycerol binding site [chemical binding]; other site 267671001484 Protein required for attachment to host cells; Region: Host_attach; pfam10116 267671001485 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 267671001486 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 267671001487 Walker A/P-loop; other site 267671001488 ATP binding site [chemical binding]; other site 267671001489 Q-loop/lid; other site 267671001490 ABC transporter signature motif; other site 267671001491 Walker B; other site 267671001492 D-loop; other site 267671001493 H-loop/switch region; other site 267671001494 FeS assembly protein SufD; Region: sufD; TIGR01981 267671001495 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 267671001496 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 267671001497 [2Fe-2S] cluster binding site [ion binding]; other site 267671001498 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 267671001499 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 267671001500 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671001501 catalytic residue [active] 267671001502 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 267671001503 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 267671001504 trimerization site [polypeptide binding]; other site 267671001505 active site 267671001506 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 267671001507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 267671001508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 267671001509 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 267671001510 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671001511 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671001512 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 267671001513 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671001514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671001515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671001516 DNA binding residues [nucleotide binding] 267671001517 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 267671001518 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 267671001519 FMN binding site [chemical binding]; other site 267671001520 active site 267671001521 catalytic residues [active] 267671001522 substrate binding site [chemical binding]; other site 267671001523 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 267671001524 Uncharacterized conserved protein [Function unknown]; Region: COG4121 267671001525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671001526 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 267671001527 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 267671001528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671001529 S-adenosylmethionine binding site [chemical binding]; other site 267671001530 Membrane protein of unknown function; Region: DUF360; pfam04020 267671001531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671001532 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671001533 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671001534 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 267671001535 putative catalytic site [active] 267671001536 metal binding site A [ion binding]; metal-binding site 267671001537 phosphate binding site [ion binding]; other site 267671001538 metal binding site C [ion binding]; metal-binding site 267671001539 metal binding site B [ion binding]; metal-binding site 267671001540 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 267671001541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671001542 putative substrate translocation pore; other site 267671001543 RibD C-terminal domain; Region: RibD_C; cl17279 267671001544 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 267671001545 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 267671001546 putative hydrophobic ligand binding site [chemical binding]; other site 267671001547 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 267671001548 putative hydrophobic ligand binding site [chemical binding]; other site 267671001549 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 267671001550 putative hydrophobic ligand binding site [chemical binding]; other site 267671001551 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 267671001552 hydrophobic ligand binding site; other site 267671001553 DoxX-like family; Region: DoxX_2; pfam13564 267671001554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671001555 dimerization interface [polypeptide binding]; other site 267671001556 putative DNA binding site [nucleotide binding]; other site 267671001557 putative Zn2+ binding site [ion binding]; other site 267671001558 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671001559 active site 267671001560 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 267671001561 Mrr N-terminal domain; Region: Mrr_N; pfam14338 267671001562 Restriction endonuclease; Region: Mrr_cat; pfam04471 267671001563 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 267671001564 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 267671001565 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 267671001566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 267671001567 Walker A/P-loop; other site 267671001568 ATP binding site [chemical binding]; other site 267671001569 Q-loop/lid; other site 267671001570 ABC transporter signature motif; other site 267671001571 Walker B; other site 267671001572 D-loop; other site 267671001573 H-loop/switch region; other site 267671001574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001575 binding surface 267671001576 TPR motif; other site 267671001577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001578 binding surface 267671001579 TPR motif; other site 267671001580 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671001581 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671001582 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 267671001583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671001584 Walker A/P-loop; other site 267671001585 ATP binding site [chemical binding]; other site 267671001586 Q-loop/lid; other site 267671001587 ABC transporter signature motif; other site 267671001588 Walker B; other site 267671001589 D-loop; other site 267671001590 H-loop/switch region; other site 267671001591 CcmB protein; Region: CcmB; cl17444 267671001592 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 267671001593 Response regulator receiver domain; Region: Response_reg; pfam00072 267671001594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671001595 active site 267671001596 phosphorylation site [posttranslational modification] 267671001597 intermolecular recognition site; other site 267671001598 dimerization interface [polypeptide binding]; other site 267671001599 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671001600 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 267671001601 ATP binding site [chemical binding]; other site 267671001602 active site 267671001603 substrate binding site [chemical binding]; other site 267671001604 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 267671001605 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 267671001606 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 267671001607 putative active site [active] 267671001608 catalytic triad [active] 267671001609 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 267671001610 Cytochrome c; Region: Cytochrom_C; pfam00034 267671001611 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 267671001612 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 267671001613 Cytochrome c; Region: Cytochrom_C; pfam00034 267671001614 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671001615 HAMP domain; Region: HAMP; pfam00672 267671001616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671001617 dimer interface [polypeptide binding]; other site 267671001618 putative CheW interface [polypeptide binding]; other site 267671001619 Ycf48-like protein; Provisional; Region: PRK13684 267671001620 MAPEG family; Region: MAPEG; pfam01124 267671001621 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 267671001622 PhoU domain; Region: PhoU; pfam01895 267671001623 PhoU domain; Region: PhoU; pfam01895 267671001624 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 267671001625 SPFH domain / Band 7 family; Region: Band_7; pfam01145 267671001626 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671001627 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 267671001628 Predicted esterase [General function prediction only]; Region: COG0400 267671001629 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 267671001630 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 267671001631 NAD(P) binding site [chemical binding]; other site 267671001632 homotetramer interface [polypeptide binding]; other site 267671001633 homodimer interface [polypeptide binding]; other site 267671001634 active site 267671001635 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 267671001636 active site 267671001637 oxyanion hole [active] 267671001638 DUF35 OB-fold domain; Region: DUF35; pfam01796 267671001639 Imelysin; Region: Peptidase_M75; pfam09375 267671001640 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 267671001641 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 267671001642 Imelysin; Region: Peptidase_M75; pfam09375 267671001643 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 267671001644 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 267671001645 N-terminal plug; other site 267671001646 ligand-binding site [chemical binding]; other site 267671001647 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 267671001648 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 267671001649 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 267671001650 active site 267671001651 Zn binding site [ion binding]; other site 267671001652 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 267671001653 Predicted amidohydrolase [General function prediction only]; Region: COG0388 267671001654 putative active site [active] 267671001655 catalytic triad [active] 267671001656 putative dimer interface [polypeptide binding]; other site 267671001657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 267671001658 FAD binding domain; Region: FAD_binding_4; pfam01565 267671001659 polyphosphate kinase; Provisional; Region: PRK05443 267671001660 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 267671001661 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 267671001662 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 267671001663 putative domain interface [polypeptide binding]; other site 267671001664 putative active site [active] 267671001665 catalytic site [active] 267671001666 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 267671001667 putative domain interface [polypeptide binding]; other site 267671001668 putative active site [active] 267671001669 catalytic site [active] 267671001670 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671001671 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671001672 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 267671001673 amphipathic channel; other site 267671001674 Asn-Pro-Ala signature motifs; other site 267671001675 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 267671001676 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 267671001677 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 267671001678 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 267671001679 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 267671001680 active site 267671001681 Riboflavin kinase; Region: Flavokinase; pfam01687 267671001682 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 267671001683 Beta-lactamase; Region: Beta-lactamase; pfam00144 267671001684 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 267671001685 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 267671001686 catalytic triad [active] 267671001687 multifunctional aminopeptidase A; Provisional; Region: PRK00913 267671001688 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 267671001689 interface (dimer of trimers) [polypeptide binding]; other site 267671001690 Substrate-binding/catalytic site; other site 267671001691 Zn-binding sites [ion binding]; other site 267671001692 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 267671001693 homotrimer interaction site [polypeptide binding]; other site 267671001694 putative active site [active] 267671001695 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671001696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671001697 S-adenosylmethionine binding site [chemical binding]; other site 267671001698 helicase 45; Provisional; Region: PTZ00424 267671001699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 267671001700 ATP binding site [chemical binding]; other site 267671001701 Mg++ binding site [ion binding]; other site 267671001702 motif III; other site 267671001703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671001704 nucleotide binding region [chemical binding]; other site 267671001705 ATP-binding site [chemical binding]; other site 267671001706 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 267671001707 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 267671001708 active site 267671001709 metal binding site [ion binding]; metal-binding site 267671001710 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671001711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671001712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671001713 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671001714 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 267671001715 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 267671001716 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 267671001717 putative homodimer interface [polypeptide binding]; other site 267671001718 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 267671001719 heterodimer interface [polypeptide binding]; other site 267671001720 homodimer interface [polypeptide binding]; other site 267671001721 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 267671001722 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 267671001723 23S rRNA interface [nucleotide binding]; other site 267671001724 L7/L12 interface [polypeptide binding]; other site 267671001725 putative thiostrepton binding site; other site 267671001726 L25 interface [polypeptide binding]; other site 267671001727 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 267671001728 mRNA/rRNA interface [nucleotide binding]; other site 267671001729 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 267671001730 23S rRNA interface [nucleotide binding]; other site 267671001731 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 267671001732 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 267671001733 core dimer interface [polypeptide binding]; other site 267671001734 peripheral dimer interface [polypeptide binding]; other site 267671001735 L10 interface [polypeptide binding]; other site 267671001736 L11 interface [polypeptide binding]; other site 267671001737 putative EF-Tu interaction site [polypeptide binding]; other site 267671001738 putative EF-G interaction site [polypeptide binding]; other site 267671001739 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 267671001740 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 267671001741 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 267671001742 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 267671001743 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 267671001744 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 267671001745 RPB10 interaction site [polypeptide binding]; other site 267671001746 RPB1 interaction site [polypeptide binding]; other site 267671001747 RPB11 interaction site [polypeptide binding]; other site 267671001748 RPB3 interaction site [polypeptide binding]; other site 267671001749 RPB12 interaction site [polypeptide binding]; other site 267671001750 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 267671001751 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 267671001752 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 267671001753 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 267671001754 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 267671001755 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 267671001756 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 267671001757 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 267671001758 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 267671001759 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 267671001760 DNA binding site [nucleotide binding] 267671001761 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 267671001762 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 267671001763 S17 interaction site [polypeptide binding]; other site 267671001764 S8 interaction site; other site 267671001765 16S rRNA interaction site [nucleotide binding]; other site 267671001766 streptomycin interaction site [chemical binding]; other site 267671001767 23S rRNA interaction site [nucleotide binding]; other site 267671001768 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 267671001769 30S ribosomal protein S7; Validated; Region: PRK05302 267671001770 thiamine monophosphate kinase; Provisional; Region: PRK05731 267671001771 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 267671001772 ATP binding site [chemical binding]; other site 267671001773 dimerization interface [polypeptide binding]; other site 267671001774 YceI-like domain; Region: YceI; pfam04264 267671001775 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 267671001776 23S rRNA interface [nucleotide binding]; other site 267671001777 L3 interface [polypeptide binding]; other site 267671001778 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 267671001779 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 267671001780 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 267671001781 motif 1; other site 267671001782 active site 267671001783 motif 2; other site 267671001784 motif 3; other site 267671001785 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 267671001786 DHHA1 domain; Region: DHHA1; pfam02272 267671001787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 267671001788 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 267671001789 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 267671001790 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 267671001791 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 267671001792 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 267671001793 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 267671001794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 267671001795 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 267671001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671001797 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 267671001798 active site 267671001799 metal binding site [ion binding]; metal-binding site 267671001800 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 267671001801 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671001802 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 267671001803 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 267671001804 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 267671001805 putative transposase OrfB; Reviewed; Region: PHA02517 267671001806 Transposase; Region: HTH_Tnp_1; pfam01527 267671001807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 267671001808 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 267671001809 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 267671001810 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 267671001811 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 267671001812 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 267671001813 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671001814 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671001815 ligand binding site [chemical binding]; other site 267671001816 flexible hinge region; other site 267671001817 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 267671001818 Acyltransferase family; Region: Acyl_transf_3; pfam01757 267671001819 Uncharacterized conserved protein [Function unknown]; Region: COG3391 267671001820 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 267671001821 structural tetrad; other site 267671001822 Cupin; Region: Cupin_6; pfam12852 267671001823 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 267671001824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671001825 substrate binding site [chemical binding]; other site 267671001826 oxyanion hole (OAH) forming residues; other site 267671001827 trimer interface [polypeptide binding]; other site 267671001828 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 267671001829 substrate binding site [chemical binding]; other site 267671001830 multimerization interface [polypeptide binding]; other site 267671001831 ATP binding site [chemical binding]; other site 267671001832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671001833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671001834 active site 267671001835 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 267671001836 putative active site [active] 267671001837 putative substrate binding site [chemical binding]; other site 267671001838 ATP binding site [chemical binding]; other site 267671001839 Phosphotransferase enzyme family; Region: APH; pfam01636 267671001840 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 267671001841 catalytic core [active] 267671001842 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671001843 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 267671001844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671001845 dimer interface [polypeptide binding]; other site 267671001846 phosphorylation site [posttranslational modification] 267671001847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671001848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671001849 ATP binding site [chemical binding]; other site 267671001850 Mg2+ binding site [ion binding]; other site 267671001851 G-X-G motif; other site 267671001852 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 267671001853 C-terminal domain interface [polypeptide binding]; other site 267671001854 GSH binding site (G-site) [chemical binding]; other site 267671001855 dimer interface [polypeptide binding]; other site 267671001856 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 267671001857 N-terminal domain interface [polypeptide binding]; other site 267671001858 dimer interface [polypeptide binding]; other site 267671001859 substrate binding pocket (H-site) [chemical binding]; other site 267671001860 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 267671001861 CoenzymeA binding site [chemical binding]; other site 267671001862 subunit interaction site [polypeptide binding]; other site 267671001863 PHB binding site; other site 267671001864 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 267671001865 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 267671001866 putative NAD(P) binding site [chemical binding]; other site 267671001867 catalytic Zn binding site [ion binding]; other site 267671001868 structural Zn binding site [ion binding]; other site 267671001869 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 267671001870 Cytochrome C biogenesis protein; Region: CcmH; cl01179 267671001871 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 267671001872 CcmE; Region: CcmE; cl00994 267671001873 Uncharacterized conserved protein [Function unknown]; Region: COG1434 267671001874 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 267671001875 putative active site [active] 267671001876 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 267671001877 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 267671001878 catalytic residues [active] 267671001879 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 267671001880 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 267671001881 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671001882 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 267671001883 Interdomain contacts; other site 267671001884 Cytokine receptor motif; other site 267671001885 Kelch motif; Region: Kelch_1; pfam01344 267671001886 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 267671001887 Family description; Region: VCBS; pfam13517 267671001888 Family description; Region: VCBS; pfam13517 267671001889 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 267671001890 RHS Repeat; Region: RHS_repeat; cl11982 267671001891 RHS Repeat; Region: RHS_repeat; pfam05593 267671001892 RHS Repeat; Region: RHS_repeat; pfam05593 267671001893 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 267671001894 Leucine rich repeat; Region: LRR_8; pfam13855 267671001895 Leucine rich repeat; Region: LRR_8; pfam13855 267671001896 Leucine rich repeat; Region: LRR_8; pfam13855 267671001897 Leucine rich repeat; Region: LRR_8; pfam13855 267671001898 Leucine rich repeat; Region: LRR_8; pfam13855 267671001899 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671001900 Leucine-rich repeats; other site 267671001901 Substrate binding site [chemical binding]; other site 267671001902 Leucine rich repeat; Region: LRR_8; pfam13855 267671001903 Leucine rich repeat; Region: LRR_8; pfam13855 267671001904 Leucine rich repeat; Region: LRR_8; pfam13855 267671001905 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 267671001906 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671001907 Leucine-rich repeats; other site 267671001908 Leucine rich repeat; Region: LRR_8; pfam13855 267671001909 Substrate binding site [chemical binding]; other site 267671001910 Leucine rich repeat; Region: LRR_8; pfam13855 267671001911 Leucine rich repeat; Region: LRR_8; pfam13855 267671001912 Leucine rich repeat; Region: LRR_8; pfam13855 267671001913 Leucine rich repeat; Region: LRR_8; pfam13855 267671001914 Leucine rich repeat; Region: LRR_8; pfam13855 267671001915 Leucine rich repeat; Region: LRR_8; pfam13855 267671001916 Leucine rich repeat; Region: LRR_8; pfam13855 267671001917 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671001918 Leucine-rich repeats; other site 267671001919 Substrate binding site [chemical binding]; other site 267671001920 Leucine rich repeat; Region: LRR_8; pfam13855 267671001921 Leucine rich repeat; Region: LRR_8; pfam13855 267671001922 Leucine rich repeat; Region: LRR_8; pfam13855 267671001923 Leucine rich repeat; Region: LRR_8; pfam13855 267671001924 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 267671001925 dimer interface [polypeptide binding]; other site 267671001926 RibD C-terminal domain; Region: RibD_C; cl17279 267671001927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 267671001928 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 267671001929 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 267671001930 TIGR01777 family protein; Region: yfcH 267671001931 putative NAD(P) binding site [chemical binding]; other site 267671001932 putative active site [active] 267671001933 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671001934 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 267671001935 active site 267671001936 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 267671001937 Mg++ binding site [ion binding]; other site 267671001938 putative catalytic motif [active] 267671001939 putative substrate binding site [chemical binding]; other site 267671001940 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 267671001941 dihydrodipicolinate synthase; Region: dapA; TIGR00674 267671001942 dimer interface [polypeptide binding]; other site 267671001943 active site 267671001944 catalytic residue [active] 267671001945 dihydrodipicolinate reductase; Provisional; Region: PRK00048 267671001946 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 267671001947 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 267671001948 TIGR00159 family protein; Region: TIGR00159 267671001949 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 267671001950 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 267671001951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671001952 TPR repeat; Region: TPR_11; pfam13414 267671001953 binding surface 267671001954 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 267671001955 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 267671001956 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 267671001957 rRNA interaction site [nucleotide binding]; other site 267671001958 S8 interaction site; other site 267671001959 putative laminin-1 binding site; other site 267671001960 elongation factor Ts; Reviewed; Region: tsf; PRK12332 267671001961 UBA/TS-N domain; Region: UBA; pfam00627 267671001962 Elongation factor TS; Region: EF_TS; pfam00889 267671001963 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 267671001964 putative nucleotide binding site [chemical binding]; other site 267671001965 uridine monophosphate binding site [chemical binding]; other site 267671001966 homohexameric interface [polypeptide binding]; other site 267671001967 ribosome recycling factor; Reviewed; Region: frr; PRK00083 267671001968 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 267671001969 hinge region; other site 267671001970 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14842 267671001971 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 267671001972 catalytic residue [active] 267671001973 putative FPP diphosphate binding site; other site 267671001974 putative FPP binding hydrophobic cleft; other site 267671001975 dimer interface [polypeptide binding]; other site 267671001976 putative IPP diphosphate binding site; other site 267671001977 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 267671001978 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 267671001979 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 267671001980 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 267671001981 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 267671001982 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 267671001983 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 267671001984 active site 267671001985 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 267671001986 RIP metalloprotease RseP; Region: TIGR00054 267671001987 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267671001988 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 267671001989 putative substrate binding region [chemical binding]; other site 267671001990 prolyl-tRNA synthetase; Provisional; Region: PRK09194 267671001991 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 267671001992 dimer interface [polypeptide binding]; other site 267671001993 motif 1; other site 267671001994 active site 267671001995 motif 2; other site 267671001996 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 267671001997 putative deacylase active site [active] 267671001998 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 267671001999 active site 267671002000 motif 3; other site 267671002001 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 267671002002 anticodon binding site; other site 267671002003 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 267671002004 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 267671002005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671002006 catalytic residue [active] 267671002007 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 267671002008 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 267671002009 substrate binding site [chemical binding]; other site 267671002010 active site 267671002011 catalytic residues [active] 267671002012 heterodimer interface [polypeptide binding]; other site 267671002013 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671002014 CHASE2 domain; Region: CHASE2; pfam05226 267671002015 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671002016 cyclase homology domain; Region: CHD; cd07302 267671002017 nucleotidyl binding site; other site 267671002018 metal binding site [ion binding]; metal-binding site 267671002019 dimer interface [polypeptide binding]; other site 267671002020 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 267671002021 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 267671002022 TPP-binding site; other site 267671002023 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 267671002024 PYR/PP interface [polypeptide binding]; other site 267671002025 dimer interface [polypeptide binding]; other site 267671002026 TPP binding site [chemical binding]; other site 267671002027 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267671002028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671002029 binding surface 267671002030 TPR motif; other site 267671002031 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 267671002032 Uncharacterized conserved protein [Function unknown]; Region: COG1262 267671002033 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 267671002034 putative active site [active] 267671002035 Beta-propeller repeat; Region: SBBP; pfam06739 267671002036 Beta-propeller repeat; Region: SBBP; pfam06739 267671002037 Beta-propeller repeat; Region: SBBP; pfam06739 267671002038 Beta-propeller repeat; Region: SBBP; pfam06739 267671002039 Beta-propeller repeat; Region: SBBP; pfam06739 267671002040 Beta-propeller repeat; Region: SBBP; pfam06739 267671002041 Beta-propeller repeat; Region: SBBP; pfam06739 267671002042 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671002043 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 267671002044 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 267671002045 heme-binding residues [chemical binding]; other site 267671002046 The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764 267671002047 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 267671002048 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 267671002049 4Fe-4S binding domain; Region: Fer4_2; pfam12797 267671002050 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 267671002051 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 267671002052 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 267671002053 Cytochrome c; Region: Cytochrom_C; pfam00034 267671002054 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 267671002055 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 267671002056 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 267671002057 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671002058 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671002059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671002060 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671002061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671002062 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671002063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671002064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671002065 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671002066 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 267671002067 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 267671002068 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 267671002069 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 267671002070 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 267671002071 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 267671002072 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671002073 Cna protein B-type domain; Region: Cna_B_2; pfam13715 267671002074 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 267671002075 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671002076 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671002077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671002078 dimerization interface [polypeptide binding]; other site 267671002079 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671002080 cyclase homology domain; Region: CHD; cd07302 267671002081 nucleotidyl binding site; other site 267671002082 metal binding site [ion binding]; metal-binding site 267671002083 dimer interface [polypeptide binding]; other site 267671002084 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671002085 cyclase homology domain; Region: CHD; cd07302 267671002086 dimer interface [polypeptide binding]; other site 267671002087 FecR protein; Region: FecR; pfam04773 267671002088 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 267671002089 transketolase; Reviewed; Region: PRK05899 267671002090 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 267671002091 TPP-binding site [chemical binding]; other site 267671002092 dimer interface [polypeptide binding]; other site 267671002093 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 267671002094 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 267671002095 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 267671002096 substrate binding pocket [chemical binding]; other site 267671002097 chain length determination region; other site 267671002098 substrate-Mg2+ binding site; other site 267671002099 catalytic residues [active] 267671002100 aspartate-rich region 1; other site 267671002101 active site lid residues [active] 267671002102 aspartate-rich region 2; other site 267671002103 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 267671002104 putative hydrophobic ligand binding site [chemical binding]; other site 267671002105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671002106 dimerization interface [polypeptide binding]; other site 267671002107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002108 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 267671002109 putative active site [active] 267671002110 heme pocket [chemical binding]; other site 267671002111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002112 putative active site [active] 267671002113 heme pocket [chemical binding]; other site 267671002114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671002115 dimer interface [polypeptide binding]; other site 267671002116 phosphorylation site [posttranslational modification] 267671002117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671002118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671002119 ATP binding site [chemical binding]; other site 267671002120 Mg2+ binding site [ion binding]; other site 267671002121 G-X-G motif; other site 267671002122 Response regulator receiver domain; Region: Response_reg; pfam00072 267671002123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671002124 active site 267671002125 phosphorylation site [posttranslational modification] 267671002126 intermolecular recognition site; other site 267671002127 dimerization interface [polypeptide binding]; other site 267671002128 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 267671002129 Pectinacetylesterase; Region: PAE; pfam03283 267671002130 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 267671002131 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 267671002132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671002133 ATP binding site [chemical binding]; other site 267671002134 putative Mg++ binding site [ion binding]; other site 267671002135 AAA domain; Region: AAA_13; pfam13166 267671002136 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 267671002137 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 267671002138 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 267671002139 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 267671002140 HsdM N-terminal domain; Region: HsdM_N; pfam12161 267671002141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671002142 S-adenosylmethionine binding site [chemical binding]; other site 267671002143 Uncharacterized conserved protein [Function unknown]; Region: COG4933 267671002144 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 267671002145 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 267671002146 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 267671002147 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09713 267671002148 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cd09714 267671002149 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 267671002150 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 267671002151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 267671002152 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 267671002153 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 267671002154 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 267671002155 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 267671002156 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267671002157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671002158 ABC transporter; Region: ABC_tran_2; pfam12848 267671002159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671002160 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267671002161 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 267671002162 active site 267671002163 catalytic tetrad [active] 267671002164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002165 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671002166 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002167 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671002168 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671002169 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671002170 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 267671002171 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 267671002172 putative active site [active] 267671002173 putative metal binding site [ion binding]; other site 267671002174 MORN repeat; Region: MORN; cl14787 267671002175 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 267671002176 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 267671002177 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 267671002178 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 267671002179 putative NAD(P) binding site [chemical binding]; other site 267671002180 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 267671002181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 267671002182 DDE superfamily endonuclease; Region: DDE_4; cl17710 267671002183 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671002184 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 267671002185 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 267671002186 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 267671002187 N-terminal plug; other site 267671002188 ligand-binding site [chemical binding]; other site 267671002189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671002190 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 267671002191 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 267671002192 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 267671002193 CoA-transferase family III; Region: CoA_transf_3; pfam02515 267671002194 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671002195 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671002196 active site 267671002197 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 267671002198 Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389 267671002199 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 267671002200 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 267671002201 dimer interface [polypeptide binding]; other site 267671002202 active site 267671002203 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671002204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 267671002205 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 267671002206 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 267671002207 active site residue [active] 267671002208 bile acid transporter; Region: bass; TIGR00841 267671002209 Sodium Bile acid symporter family; Region: SBF; cl17470 267671002210 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 267671002211 putative transposase OrfB; Reviewed; Region: PHA02517 267671002212 Integrase core domain; Region: rve; pfam00665 267671002213 Integrase core domain; Region: rve_3; pfam13683 267671002214 Transposase; Region: HTH_Tnp_1; pfam01527 267671002215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 267671002216 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 267671002217 EamA-like transporter family; Region: EamA; pfam00892 267671002218 EamA-like transporter family; Region: EamA; pfam00892 267671002219 Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246 267671002220 active site 267671002221 Zn binding site [ion binding]; other site 267671002222 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 267671002223 Uncharacterized conserved protein [Function unknown]; Region: COG1262 267671002224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671002225 Uncharacterized conserved protein [Function unknown]; Region: COG3349 267671002226 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 267671002227 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267671002228 activation loop (A-loop); other site 267671002229 AAA ATPase domain; Region: AAA_16; pfam13191 267671002230 Predicted ATPase [General function prediction only]; Region: COG3899 267671002231 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002232 GAF domain; Region: GAF; pfam01590 267671002233 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671002234 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671002235 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 267671002236 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 267671002237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 267671002238 Soluble P-type ATPase [General function prediction only]; Region: COG4087 267671002239 K+-transporting ATPase, c chain; Region: KdpC; cl00944 267671002240 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 267671002241 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 267671002242 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 267671002243 Ligand Binding Site [chemical binding]; other site 267671002244 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 267671002245 GAF domain; Region: GAF_3; pfam13492 267671002246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671002247 dimer interface [polypeptide binding]; other site 267671002248 phosphorylation site [posttranslational modification] 267671002249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671002250 ATP binding site [chemical binding]; other site 267671002251 Mg2+ binding site [ion binding]; other site 267671002252 G-X-G motif; other site 267671002253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267671002254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671002255 active site 267671002256 phosphorylation site [posttranslational modification] 267671002257 intermolecular recognition site; other site 267671002258 dimerization interface [polypeptide binding]; other site 267671002259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267671002260 DNA binding site [nucleotide binding] 267671002261 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671002262 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671002263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671002264 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671002265 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671002266 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 267671002267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671002268 S-adenosylmethionine binding site [chemical binding]; other site 267671002269 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671002270 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 267671002271 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 267671002272 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671002273 anti sigma factor interaction site; other site 267671002274 regulatory phosphorylation site [posttranslational modification]; other site 267671002275 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 267671002276 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 267671002277 ferric uptake regulator; Provisional; Region: fur; PRK09462 267671002278 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 267671002279 metal binding site 2 [ion binding]; metal-binding site 267671002280 putative DNA binding helix; other site 267671002281 metal binding site 1 [ion binding]; metal-binding site 267671002282 dimer interface [polypeptide binding]; other site 267671002283 structural Zn2+ binding site [ion binding]; other site 267671002284 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671002285 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671002286 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 267671002287 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 267671002288 dimerization interface [polypeptide binding]; other site 267671002289 active site 267671002290 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 267671002291 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671002292 Zn2+ binding site [ion binding]; other site 267671002293 Mg2+ binding site [ion binding]; other site 267671002294 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 267671002295 synthetase active site [active] 267671002296 NTP binding site [chemical binding]; other site 267671002297 metal binding site [ion binding]; metal-binding site 267671002298 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 267671002299 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 267671002300 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 267671002301 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 267671002302 adenylosuccinate lyase; Provisional; Region: PRK07492 267671002303 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 267671002304 tetramer interface [polypeptide binding]; other site 267671002305 active site 267671002306 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 267671002307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671002308 NAD(P) binding site [chemical binding]; other site 267671002309 active site 267671002310 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 267671002311 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 267671002312 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 267671002313 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 267671002314 Ligand binding site; other site 267671002315 Putative Catalytic site; other site 267671002316 DXD motif; other site 267671002317 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671002318 anti sigma factor interaction site; other site 267671002319 regulatory phosphorylation site [posttranslational modification]; other site 267671002320 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 267671002321 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 267671002322 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 267671002323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671002324 TPR repeat; Region: TPR_11; pfam13414 267671002325 TPR motif; other site 267671002326 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 267671002327 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 267671002328 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671002329 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671002330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671002331 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671002332 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 267671002333 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 267671002334 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 267671002335 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 267671002336 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267671002337 protein binding site [polypeptide binding]; other site 267671002338 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 267671002339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671002340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671002341 homodimer interface [polypeptide binding]; other site 267671002342 catalytic residue [active] 267671002343 glutamate racemase; Provisional; Region: PRK00865 267671002344 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671002345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671002346 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 267671002347 cyclase homology domain; Region: CHD; cd07302 267671002348 nucleotidyl binding site; other site 267671002349 metal binding site [ion binding]; metal-binding site 267671002350 dimer interface [polypeptide binding]; other site 267671002351 Bacterial SH3 domain; Region: SH3_3; pfam08239 267671002352 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 267671002353 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671002354 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671002355 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 267671002356 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671002357 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 267671002358 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 267671002359 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671002360 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 267671002361 Leucine-rich repeats; other site 267671002362 Substrate binding site [chemical binding]; other site 267671002363 Leucine rich repeat; Region: LRR_8; pfam13855 267671002364 Leucine rich repeat; Region: LRR_8; pfam13855 267671002365 CARDB; Region: CARDB; pfam07705 267671002366 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 267671002367 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 267671002368 Repair protein; Region: Repair_PSII; pfam04536 267671002369 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 267671002370 Repair protein; Region: Repair_PSII; pfam04536 267671002371 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 267671002372 putative single-stranded DNA-binding protein; Region: PHA01740 267671002373 Domain of unknown function (DUF389); Region: DUF389; pfam04087 267671002374 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 267671002375 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 267671002376 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 267671002377 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 267671002378 Methyltransferase domain; Region: Methyltransf_18; pfam12847 267671002379 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 267671002380 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671002381 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671002382 poly(A) polymerase; Region: pcnB; TIGR01942 267671002383 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 267671002384 active site 267671002385 NTP binding site [chemical binding]; other site 267671002386 metal binding triad [ion binding]; metal-binding site 267671002387 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 267671002388 DHH family; Region: DHH; pfam01368 267671002389 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 267671002390 DHHA1 domain; Region: DHHA1; pfam02272 267671002391 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 267671002392 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 267671002393 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 267671002394 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 267671002395 active site 267671002396 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 267671002397 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 267671002398 active site 267671002399 NAD binding site [chemical binding]; other site 267671002400 metal binding site [ion binding]; metal-binding site 267671002401 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 267671002402 Predicted methyltransferases [General function prediction only]; Region: COG0313 267671002403 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 267671002404 putative SAM binding site [chemical binding]; other site 267671002405 putative homodimer interface [polypeptide binding]; other site 267671002406 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 267671002407 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 267671002408 multimer interface [polypeptide binding]; other site 267671002409 active site 267671002410 catalytic triad [active] 267671002411 protein interface 1 [polypeptide binding]; other site 267671002412 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 267671002413 homodimer interface [polypeptide binding]; other site 267671002414 NAD binding pocket [chemical binding]; other site 267671002415 ATP binding pocket [chemical binding]; other site 267671002416 Mg binding site [ion binding]; other site 267671002417 active-site loop [active] 267671002418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 267671002419 active site 267671002420 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671002421 FtsX-like permease family; Region: FtsX; pfam02687 267671002422 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 267671002423 FtsX-like permease family; Region: FtsX; pfam02687 267671002424 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 267671002425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267671002426 Walker A/P-loop; other site 267671002427 ATP binding site [chemical binding]; other site 267671002428 Q-loop/lid; other site 267671002429 ABC transporter signature motif; other site 267671002430 Walker B; other site 267671002431 D-loop; other site 267671002432 H-loop/switch region; other site 267671002433 Stage II sporulation protein; Region: SpoIID; pfam08486 267671002434 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 267671002435 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 267671002436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671002437 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 267671002438 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 267671002439 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 267671002440 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 267671002441 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671002442 active site 267671002443 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671002444 cyclase homology domain; Region: CHD; cd07302 267671002445 nucleotidyl binding site; other site 267671002446 metal binding site [ion binding]; metal-binding site 267671002447 dimer interface [polypeptide binding]; other site 267671002448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 267671002449 Leucine rich repeat; Region: LRR_8; pfam13855 267671002450 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671002451 Leucine-rich repeats; other site 267671002452 Substrate binding site [chemical binding]; other site 267671002453 Leucine rich repeat; Region: LRR_8; pfam13855 267671002454 Leucine rich repeat; Region: LRR_8; pfam13855 267671002455 Leucine rich repeat; Region: LRR_8; pfam13855 267671002456 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671002457 Leucine-rich repeats; other site 267671002458 Substrate binding site [chemical binding]; other site 267671002459 Leucine rich repeat; Region: LRR_8; pfam13855 267671002460 Leucine rich repeat; Region: LRR_8; pfam13855 267671002461 Leucine rich repeat; Region: LRR_8; pfam13855 267671002462 Leucine rich repeat; Region: LRR_8; pfam13855 267671002463 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 267671002464 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 267671002465 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671002466 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671002467 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 267671002468 active site 267671002469 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 267671002470 B12 binding site [chemical binding]; other site 267671002471 cobalt ligand [ion binding]; other site 267671002472 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 267671002473 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 267671002474 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 267671002475 putative active site [active] 267671002476 putative substrate binding site [chemical binding]; other site 267671002477 putative coenzyme B12 binding site [chemical binding]; other site 267671002478 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 267671002479 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267671002480 putative acyl-acceptor binding pocket; other site 267671002481 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 267671002482 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 267671002483 active site 267671002484 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 267671002485 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 267671002486 Response regulator receiver domain; Region: Response_reg; pfam00072 267671002487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671002488 active site 267671002489 phosphorylation site [posttranslational modification] 267671002490 intermolecular recognition site; other site 267671002491 dimerization interface [polypeptide binding]; other site 267671002492 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 267671002493 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267671002494 protein binding site [polypeptide binding]; other site 267671002495 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 267671002496 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 267671002497 Rhodanese Homology Domain; Region: RHOD; smart00450 267671002498 active site residue [active] 267671002499 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 267671002500 active site residue [active] 267671002501 alpha-glucosidase; Provisional; Region: PRK10426 267671002502 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 267671002503 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 267671002504 putative active site [active] 267671002505 putative catalytic site [active] 267671002506 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 267671002507 Galactose oxidase, central domain; Region: Kelch_3; cl02701 267671002508 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 267671002509 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 267671002510 Galactose oxidase, central domain; Region: Kelch_3; cl02701 267671002511 Bor protein; Region: Lambda_Bor; pfam06291 267671002512 FecR protein; Region: FecR; pfam04773 267671002513 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 267671002514 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 267671002515 dimerization interface [polypeptide binding]; other site 267671002516 putative ATP binding site [chemical binding]; other site 267671002517 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 267671002518 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 267671002519 Cl- selectivity filter; other site 267671002520 Cl- binding residues [ion binding]; other site 267671002521 pore gating glutamate residue; other site 267671002522 dimer interface [polypeptide binding]; other site 267671002523 PAS domain S-box; Region: sensory_box; TIGR00229 267671002524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002525 putative active site [active] 267671002526 heme pocket [chemical binding]; other site 267671002527 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002528 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002529 metal binding site [ion binding]; metal-binding site 267671002530 active site 267671002531 I-site; other site 267671002532 PAS domain S-box; Region: sensory_box; TIGR00229 267671002533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002534 putative active site [active] 267671002535 heme pocket [chemical binding]; other site 267671002536 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002538 metal binding site [ion binding]; metal-binding site 267671002539 active site 267671002540 I-site; other site 267671002541 PAS domain S-box; Region: sensory_box; TIGR00229 267671002542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002543 putative active site [active] 267671002544 heme pocket [chemical binding]; other site 267671002545 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002547 metal binding site [ion binding]; metal-binding site 267671002548 active site 267671002549 I-site; other site 267671002550 PAS domain S-box; Region: sensory_box; TIGR00229 267671002551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002552 putative active site [active] 267671002553 heme pocket [chemical binding]; other site 267671002554 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002555 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002556 metal binding site [ion binding]; metal-binding site 267671002557 active site 267671002558 I-site; other site 267671002559 PAS domain S-box; Region: sensory_box; TIGR00229 267671002560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002561 putative active site [active] 267671002562 heme pocket [chemical binding]; other site 267671002563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002565 metal binding site [ion binding]; metal-binding site 267671002566 active site 267671002567 I-site; other site 267671002568 PAS domain S-box; Region: sensory_box; TIGR00229 267671002569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002570 putative active site [active] 267671002571 heme pocket [chemical binding]; other site 267671002572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002574 metal binding site [ion binding]; metal-binding site 267671002575 active site 267671002576 I-site; other site 267671002577 PAS domain S-box; Region: sensory_box; TIGR00229 267671002578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002579 putative active site [active] 267671002580 heme pocket [chemical binding]; other site 267671002581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002583 metal binding site [ion binding]; metal-binding site 267671002584 active site 267671002585 I-site; other site 267671002586 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 267671002587 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 267671002588 domain interfaces; other site 267671002589 active site 267671002590 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 267671002591 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 267671002592 putative active site [active] 267671002593 Zn binding site [ion binding]; other site 267671002594 Response regulator receiver domain; Region: Response_reg; pfam00072 267671002595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671002596 active site 267671002597 phosphorylation site [posttranslational modification] 267671002598 intermolecular recognition site; other site 267671002599 dimerization interface [polypeptide binding]; other site 267671002600 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671002601 Melibiase; Region: Melibiase; pfam02065 267671002602 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 267671002603 catalytic site [active] 267671002604 putative active site [active] 267671002605 putative substrate binding site [chemical binding]; other site 267671002606 DNA repair protein RadA; Provisional; Region: PRK11823 267671002607 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 267671002608 Walker A motif; other site 267671002609 ATP binding site [chemical binding]; other site 267671002610 Walker B motif; other site 267671002611 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 267671002612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671002613 Zn2+ binding site [ion binding]; other site 267671002614 Mg2+ binding site [ion binding]; other site 267671002615 short chain dehydrogenase; Provisional; Region: PRK08303 267671002616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671002617 NAD(P) binding site [chemical binding]; other site 267671002618 active site 267671002619 Predicted transcriptional regulator [Transcription]; Region: COG2378 267671002620 HTH domain; Region: HTH_11; pfam08279 267671002621 WYL domain; Region: WYL; pfam13280 267671002622 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 267671002623 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 267671002624 RuvA N terminal domain; Region: RuvA_N; pfam01330 267671002625 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671002626 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671002627 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 267671002628 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 267671002629 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 267671002630 active site 267671002631 homodimer interface [polypeptide binding]; other site 267671002632 SAM binding site [chemical binding]; other site 267671002633 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 267671002634 active site 267671002635 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 267671002636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671002637 non-specific DNA binding site [nucleotide binding]; other site 267671002638 salt bridge; other site 267671002639 sequence-specific DNA binding site [nucleotide binding]; other site 267671002640 Cupin domain; Region: Cupin_2; pfam07883 267671002641 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 267671002642 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 267671002643 transmembrane helices; other site 267671002644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 267671002645 metal binding site 2 [ion binding]; metal-binding site 267671002646 putative DNA binding helix; other site 267671002647 structural Zn2+ binding site [ion binding]; other site 267671002648 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 267671002649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 267671002650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 267671002651 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267671002652 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 267671002653 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 267671002654 HEPN domain; Region: HEPN; pfam05168 267671002655 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 267671002656 active site 267671002657 NTP binding site [chemical binding]; other site 267671002658 metal binding triad [ion binding]; metal-binding site 267671002659 antibiotic binding site [chemical binding]; other site 267671002660 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 267671002661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671002662 S-adenosylmethionine binding site [chemical binding]; other site 267671002663 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 267671002664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671002665 binding surface 267671002666 TPR motif; other site 267671002667 Predicted esterase [General function prediction only]; Region: COG0400 267671002668 Protein of unknown function (DUF342); Region: DUF342; pfam03961 267671002669 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 267671002670 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 267671002671 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 267671002672 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 267671002673 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 267671002674 active site residue [active] 267671002675 Leucine rich repeat; Region: LRR_8; pfam13855 267671002676 Leucine rich repeat; Region: LRR_8; pfam13855 267671002677 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 267671002678 Predicted amidohydrolase [General function prediction only]; Region: COG0388 267671002679 active site 267671002680 catalytic triad [active] 267671002681 dimer interface [polypeptide binding]; other site 267671002682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671002683 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 267671002684 catalytic site [active] 267671002685 Putative Ig domain; Region: He_PIG; pfam05345 267671002686 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 267671002687 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 267671002688 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 267671002689 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 267671002690 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 267671002691 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 267671002692 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 267671002693 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002694 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671002695 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671002696 Zn2+ binding site [ion binding]; other site 267671002697 Mg2+ binding site [ion binding]; other site 267671002698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671002699 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 267671002700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671002701 non-specific DNA binding site [nucleotide binding]; other site 267671002702 salt bridge; other site 267671002703 sequence-specific DNA binding site [nucleotide binding]; other site 267671002704 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 267671002705 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 267671002706 PemK-like protein; Region: PemK; pfam02452 267671002707 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 267671002708 ornithine carbamoyltransferase; Provisional; Region: PRK14804 267671002709 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 267671002710 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 267671002711 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 267671002712 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002713 GAF domain; Region: GAF; pfam01590 267671002714 cyclase homology domain; Region: CHD; cd07302 267671002715 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671002716 nucleotidyl binding site; other site 267671002717 metal binding site [ion binding]; metal-binding site 267671002718 dimer interface [polypeptide binding]; other site 267671002719 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671002720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671002721 ligand binding site [chemical binding]; other site 267671002722 flexible hinge region; other site 267671002723 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 267671002724 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 267671002725 active site 267671002726 nucleophile elbow; other site 267671002727 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 267671002728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002729 putative active site [active] 267671002730 heme pocket [chemical binding]; other site 267671002731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002732 putative active site [active] 267671002733 heme pocket [chemical binding]; other site 267671002734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002735 GAF domain; Region: GAF; pfam01590 267671002736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002737 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 267671002738 putative active site [active] 267671002739 heme pocket [chemical binding]; other site 267671002740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671002741 dimer interface [polypeptide binding]; other site 267671002742 phosphorylation site [posttranslational modification] 267671002743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671002744 ATP binding site [chemical binding]; other site 267671002745 Mg2+ binding site [ion binding]; other site 267671002746 G-X-G motif; other site 267671002747 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671002748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671002749 active site 267671002750 phosphorylation site [posttranslational modification] 267671002751 intermolecular recognition site; other site 267671002752 dimerization interface [polypeptide binding]; other site 267671002753 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671002754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 267671002755 active site 267671002756 phosphorylation site [posttranslational modification] 267671002757 intermolecular recognition site; other site 267671002758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671002759 dimer interface [polypeptide binding]; other site 267671002760 phosphorylation site [posttranslational modification] 267671002761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671002762 ATP binding site [chemical binding]; other site 267671002763 Mg2+ binding site [ion binding]; other site 267671002764 G-X-G motif; other site 267671002765 Response regulator receiver domain; Region: Response_reg; pfam00072 267671002766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671002767 active site 267671002768 phosphorylation site [posttranslational modification] 267671002769 intermolecular recognition site; other site 267671002770 dimerization interface [polypeptide binding]; other site 267671002771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671002772 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 267671002773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 267671002774 CoenzymeA binding site [chemical binding]; other site 267671002775 subunit interaction site [polypeptide binding]; other site 267671002776 PHB binding site; other site 267671002777 YceI-like domain; Region: YceI; pfam04264 267671002778 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 267671002779 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 267671002780 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671002781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671002782 dimer interface [polypeptide binding]; other site 267671002783 putative CheW interface [polypeptide binding]; other site 267671002784 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671002785 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671002786 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671002787 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671002788 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 267671002789 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 267671002790 dimer interface [polypeptide binding]; other site 267671002791 decamer (pentamer of dimers) interface [polypeptide binding]; other site 267671002792 catalytic triad [active] 267671002793 peroxidatic and resolving cysteines [active] 267671002794 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 267671002795 FeS assembly protein SufB; Region: sufB; TIGR01980 267671002796 PAS domain S-box; Region: sensory_box; TIGR00229 267671002797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002798 putative active site [active] 267671002799 heme pocket [chemical binding]; other site 267671002800 PAS domain S-box; Region: sensory_box; TIGR00229 267671002801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002802 putative active site [active] 267671002803 heme pocket [chemical binding]; other site 267671002804 PAS domain S-box; Region: sensory_box; TIGR00229 267671002805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002806 putative active site [active] 267671002807 heme pocket [chemical binding]; other site 267671002808 PAS domain S-box; Region: sensory_box; TIGR00229 267671002809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002810 putative active site [active] 267671002811 heme pocket [chemical binding]; other site 267671002812 PAS domain S-box; Region: sensory_box; TIGR00229 267671002813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671002814 putative active site [active] 267671002815 heme pocket [chemical binding]; other site 267671002816 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671002817 GAF domain; Region: GAF; pfam01590 267671002818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671002819 dimer interface [polypeptide binding]; other site 267671002820 phosphorylation site [posttranslational modification] 267671002821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671002822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671002823 ATP binding site [chemical binding]; other site 267671002824 Mg2+ binding site [ion binding]; other site 267671002825 G-X-G motif; other site 267671002826 TPR repeat; Region: TPR_11; pfam13414 267671002827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671002828 binding surface 267671002829 TPR motif; other site 267671002830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671002831 binding surface 267671002832 TPR repeat; Region: TPR_11; pfam13414 267671002833 TPR motif; other site 267671002834 TPR repeat; Region: TPR_11; pfam13414 267671002835 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 267671002836 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 267671002837 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 267671002838 FecR protein; Region: FecR; pfam04773 267671002839 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 267671002840 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 267671002841 oligomer interface [polypeptide binding]; other site 267671002842 metal binding site [ion binding]; metal-binding site 267671002843 metal binding site [ion binding]; metal-binding site 267671002844 putative Cl binding site [ion binding]; other site 267671002845 aspartate ring; other site 267671002846 basic sphincter; other site 267671002847 hydrophobic gate; other site 267671002848 periplasmic entrance; other site 267671002849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671002850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671002851 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 267671002852 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 267671002853 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 267671002854 Catalytic site [active] 267671002855 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 267671002856 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 267671002857 F0F1 ATP synthase subunit A; Provisional; Region: PRK13417 267671002858 F0F1 ATP synthase subunit B; Provisional; Region: PRK13460 267671002859 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13434 267671002860 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 267671002861 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 267671002862 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 267671002863 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 267671002864 beta subunit interaction interface [polypeptide binding]; other site 267671002865 Walker A motif; other site 267671002866 ATP binding site [chemical binding]; other site 267671002867 Walker B motif; other site 267671002868 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 267671002869 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 267671002870 core domain interface [polypeptide binding]; other site 267671002871 delta subunit interface [polypeptide binding]; other site 267671002872 epsilon subunit interface [polypeptide binding]; other site 267671002873 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 267671002874 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 267671002875 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 267671002876 alpha subunit interaction interface [polypeptide binding]; other site 267671002877 Walker A motif; other site 267671002878 ATP binding site [chemical binding]; other site 267671002879 Walker B motif; other site 267671002880 inhibitor binding site; inhibition site 267671002881 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 267671002882 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444 267671002883 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 267671002884 gamma subunit interface [polypeptide binding]; other site 267671002885 epsilon subunit interface [polypeptide binding]; other site 267671002886 LBP interface [polypeptide binding]; other site 267671002887 SLBB domain; Region: SLBB; pfam10531 267671002888 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 267671002889 GAF domain; Region: GAF_3; pfam13492 267671002890 GAF domain; Region: GAF; pfam01590 267671002891 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671002892 A new structural DNA glycosylase; Region: AlkD_like; cl11434 267671002893 active site 267671002894 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 267671002895 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 267671002896 rod shape-determining protein MreB; Provisional; Region: PRK13927 267671002897 MreB and similar proteins; Region: MreB_like; cd10225 267671002898 nucleotide binding site [chemical binding]; other site 267671002899 Mg binding site [ion binding]; other site 267671002900 putative protofilament interaction site [polypeptide binding]; other site 267671002901 RodZ interaction site [polypeptide binding]; other site 267671002902 rod shape-determining protein MreC; Provisional; Region: PRK13922 267671002903 rod shape-determining protein MreC; Region: MreC; pfam04085 267671002904 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 267671002905 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 267671002906 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 267671002907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 267671002908 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 267671002909 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 267671002910 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 267671002911 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 267671002912 active site 267671002913 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 267671002914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 267671002915 substrate binding pocket [chemical binding]; other site 267671002916 membrane-bound complex binding site; other site 267671002917 hinge residues; other site 267671002918 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 267671002919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 267671002920 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 267671002921 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 267671002922 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 267671002923 putative acyl-acceptor binding pocket; other site 267671002924 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 267671002925 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267671002926 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671002927 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 267671002928 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 267671002929 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 267671002930 carboxyltransferase (CT) interaction site; other site 267671002931 biotinylation site [posttranslational modification]; other site 267671002932 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 267671002933 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 267671002934 G1 box; other site 267671002935 putative GEF interaction site [polypeptide binding]; other site 267671002936 GTP/Mg2+ binding site [chemical binding]; other site 267671002937 Switch I region; other site 267671002938 G2 box; other site 267671002939 G3 box; other site 267671002940 Switch II region; other site 267671002941 G4 box; other site 267671002942 G5 box; other site 267671002943 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 267671002944 Domain of unknown function (DU1801); Region: DUF1801; cl17490 267671002945 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 267671002946 Predicted transcriptional regulator [Transcription]; Region: COG1959 267671002947 Transcriptional regulator; Region: Rrf2; pfam02082 267671002948 Transcriptional regulator; Region: Rrf2; cl17282 267671002949 Uncharacterized conserved protein [Function unknown]; Region: COG1359 267671002950 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 267671002951 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 267671002952 FMN binding site [chemical binding]; other site 267671002953 substrate binding site [chemical binding]; other site 267671002954 putative catalytic residue [active] 267671002955 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 267671002956 Protein of unknown function (DUF445); Region: DUF445; pfam04286 267671002957 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267671002958 Histidine kinase; Region: HisKA_2; pfam07568 267671002959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267671002960 Mg2+ binding site [ion binding]; other site 267671002961 G-X-G motif; other site 267671002962 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 267671002963 Cysteine-rich domain; Region: CCG; pfam02754 267671002964 Cysteine-rich domain; Region: CCG; pfam02754 267671002965 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 267671002966 Ligand binding site; other site 267671002967 Putative Catalytic site; other site 267671002968 DXD motif; other site 267671002969 GtrA-like protein; Region: GtrA; pfam04138 267671002970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671002971 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 267671002972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671002973 FeS/SAM binding site; other site 267671002974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671002975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671002976 metal binding site [ion binding]; metal-binding site 267671002977 active site 267671002978 I-site; other site 267671002979 Sporulation and spore germination; Region: Germane; pfam10646 267671002980 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 267671002981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267671002982 motif II; other site 267671002983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 267671002984 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 267671002985 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 267671002986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671002987 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 267671002988 Protein of unknown function, DUF393; Region: DUF393; pfam04134 267671002989 acetylglutamate kinase; Provisional; Region: PRK04531 267671002990 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 267671002991 DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish; Region: DUF619-NAGS-U; cd04265 267671002992 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 267671002993 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 267671002994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671002995 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 267671002996 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 267671002997 heme binding site [chemical binding]; other site 267671002998 ferroxidase pore; other site 267671002999 ferroxidase diiron center [ion binding]; other site 267671003000 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 267671003001 active site 267671003002 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 267671003003 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 267671003004 putative active site [active] 267671003005 proline aminopeptidase P II; Provisional; Region: PRK10879 267671003006 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 267671003007 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 267671003008 active site 267671003009 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671003010 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671003011 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671003012 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671003013 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 267671003014 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 267671003015 metal binding site [ion binding]; metal-binding site 267671003016 dimer interface [polypeptide binding]; other site 267671003017 Methyltransferase domain; Region: Methyltransf_26; pfam13659 267671003018 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 267671003019 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 267671003020 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 267671003021 SAF-like; Region: SAF_2; pfam13144 267671003022 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 267671003023 Flagellar L-ring protein; Region: FlgH; cl17277 267671003024 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 267671003025 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 267671003026 Rod binding protein; Region: Rod-binding; pfam10135 267671003027 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 267671003028 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 267671003029 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 267671003030 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 267671003031 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 267671003032 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 267671003033 ring oligomerisation interface [polypeptide binding]; other site 267671003034 ATP/Mg binding site [chemical binding]; other site 267671003035 stacking interactions; other site 267671003036 hinge regions; other site 267671003037 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 267671003038 oligomerisation interface [polypeptide binding]; other site 267671003039 mobile loop; other site 267671003040 roof hairpin; other site 267671003041 photolyase PhrII; Region: phr2; TIGR00591 267671003042 Protein of unknown function (DUF962); Region: DUF962; pfam06127 267671003043 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 267671003044 cyclase homology domain; Region: CHD; cd07302 267671003045 nucleotidyl binding site; other site 267671003046 metal binding site [ion binding]; metal-binding site 267671003047 dimer interface [polypeptide binding]; other site 267671003048 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 267671003049 NADH(P)-binding; Region: NAD_binding_10; pfam13460 267671003050 NAD binding site [chemical binding]; other site 267671003051 active site 267671003052 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 267671003053 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 267671003054 N-terminal plug; other site 267671003055 ligand-binding site [chemical binding]; other site 267671003056 Integrase core domain; Region: rve; pfam00665 267671003057 Integrase core domain; Region: rve_3; pfam13683 267671003058 Transposase; Region: HTH_Tnp_1; pfam01527 267671003059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 267671003060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671003061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671003062 active site 267671003063 Surface lipoprotein of Spirochaetales order; Region: Lipl32; pfam12103 267671003064 ParB-like nuclease domain; Region: ParBc; pfam02195 267671003065 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 267671003066 S-adenosylmethionine synthetase; Validated; Region: PRK05250 267671003067 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 267671003068 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 267671003069 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 267671003070 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 267671003071 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 267671003072 PYR/PP interface [polypeptide binding]; other site 267671003073 dimer interface [polypeptide binding]; other site 267671003074 TPP binding site [chemical binding]; other site 267671003075 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267671003076 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 267671003077 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 267671003078 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 267671003079 NAD(P) binding site [chemical binding]; other site 267671003080 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671003081 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 267671003082 putative active site [active] 267671003083 putative catalytic site [active] 267671003084 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 267671003085 active site 2 [active] 267671003086 active site 1 [active] 267671003087 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 267671003088 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 267671003089 active site 267671003090 Zn binding site [ion binding]; other site 267671003091 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 267671003092 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 267671003093 C-terminal domain interface [polypeptide binding]; other site 267671003094 GSH binding site (G-site) [chemical binding]; other site 267671003095 dimer interface [polypeptide binding]; other site 267671003096 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 267671003097 putative N-terminal domain interface [polypeptide binding]; other site 267671003098 putative dimer interface [polypeptide binding]; other site 267671003099 putative substrate binding pocket (H-site) [chemical binding]; other site 267671003100 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 267671003101 classical (c) SDRs; Region: SDR_c; cd05233 267671003102 NAD(P) binding site [chemical binding]; other site 267671003103 active site 267671003104 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 267671003105 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 267671003106 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 267671003107 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 267671003108 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 267671003109 Protein of unknown function (DUF971); Region: DUF971; pfam06155 267671003110 flagellar motor switch protein; Validated; Region: PRK08119 267671003111 flagellar motor switch protein FliN; Region: fliN; TIGR02480 267671003112 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 267671003113 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 267671003114 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 267671003115 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 267671003116 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12773 267671003117 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 267671003118 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 267671003119 FHIPEP family; Region: FHIPEP; pfam00771 267671003120 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724 267671003121 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 267671003122 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 267671003123 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 267671003124 P-loop; other site 267671003125 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 267671003126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671003127 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671003128 DNA binding residues [nucleotide binding] 267671003129 Protein of unknown function (DUF342); Region: DUF342; pfam03961 267671003130 hypothetical protein; Provisional; Region: PRK04323 267671003131 TOBE domain; Region: TOBE_2; pfam08402 267671003132 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 267671003133 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 267671003134 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 267671003135 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 267671003136 Walker A motif; other site 267671003137 ATP binding site [chemical binding]; other site 267671003138 Walker B motif; other site 267671003139 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 267671003140 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 267671003141 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 267671003142 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 267671003143 FliG C-terminal domain; Region: FliG_C; pfam01706 267671003144 flagellar assembly protein H; Validated; Region: fliH; PRK06669 267671003145 Flagellar assembly protein FliH; Region: FliH; pfam02108 267671003146 Uncharacterized conserved protein [Function unknown]; Region: COG3268 267671003147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671003148 NAD(P) binding site [chemical binding]; other site 267671003149 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 267671003150 sugar binding site [chemical binding]; other site 267671003151 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671003152 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671003153 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 267671003154 NeuB family; Region: NeuB; pfam03102 267671003155 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 267671003156 Sulfatase; Region: Sulfatase; pfam00884 267671003157 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 267671003158 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 267671003159 G1 box; other site 267671003160 GTP/Mg2+ binding site [chemical binding]; other site 267671003161 Switch I region; other site 267671003162 G2 box; other site 267671003163 G3 box; other site 267671003164 Switch II region; other site 267671003165 G4 box; other site 267671003166 G5 box; other site 267671003167 Nucleoside recognition; Region: Gate; pfam07670 267671003168 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 267671003169 Nucleoside recognition; Region: Gate; pfam07670 267671003170 FeoA domain; Region: FeoA; pfam04023 267671003171 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 267671003172 ABC1 family; Region: ABC1; cl17513 267671003173 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 267671003174 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 267671003175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671003176 dimer interface [polypeptide binding]; other site 267671003177 putative CheW interface [polypeptide binding]; other site 267671003178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003179 TPR repeat; Region: TPR_11; pfam13414 267671003180 binding surface 267671003181 TPR motif; other site 267671003182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671003183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003184 binding surface 267671003185 TPR motif; other site 267671003186 TPR repeat; Region: TPR_11; pfam13414 267671003187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003188 binding surface 267671003189 TPR motif; other site 267671003190 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671003191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003192 TPR motif; other site 267671003193 binding surface 267671003194 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 267671003195 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 267671003196 PYR/PP interface [polypeptide binding]; other site 267671003197 dimer interface [polypeptide binding]; other site 267671003198 TPP binding site [chemical binding]; other site 267671003199 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 267671003200 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 267671003201 TPP-binding site [chemical binding]; other site 267671003202 dimer interface [polypeptide binding]; other site 267671003203 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 267671003204 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 267671003205 putative valine binding site [chemical binding]; other site 267671003206 dimer interface [polypeptide binding]; other site 267671003207 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 267671003208 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671003209 active site 267671003210 putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539 267671003211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671003212 FeS/SAM binding site; other site 267671003213 HemN C-terminal domain; Region: HemN_C; pfam06969 267671003214 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 267671003215 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 267671003216 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 267671003217 active site 267671003218 catalytic triad [active] 267671003219 oxyanion hole [active] 267671003220 switch loop; other site 267671003221 trigger factor; Region: tig; TIGR00115 267671003222 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 267671003223 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 267671003224 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 267671003225 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 267671003226 oligomer interface [polypeptide binding]; other site 267671003227 active site residues [active] 267671003228 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 267671003229 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 267671003230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671003231 Walker A motif; other site 267671003232 ATP binding site [chemical binding]; other site 267671003233 Walker B motif; other site 267671003234 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 267671003235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671003236 Coenzyme A binding pocket [chemical binding]; other site 267671003237 Phosphate transporter family; Region: PHO4; cl00396 267671003238 Phosphate transporter family; Region: PHO4; cl00396 267671003239 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 267671003240 serine/threonine protein kinase; Provisional; Region: PRK11768 267671003241 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 267671003242 RNA recognition motif; Region: RRM; smart00360 267671003243 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 267671003244 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 267671003245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671003246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671003247 dimer interface [polypeptide binding]; other site 267671003248 phosphorylation site [posttranslational modification] 267671003249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003250 ATP binding site [chemical binding]; other site 267671003251 Mg2+ binding site [ion binding]; other site 267671003252 G-X-G motif; other site 267671003253 PAS domain S-box; Region: sensory_box; TIGR00229 267671003254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671003255 putative active site [active] 267671003256 heme pocket [chemical binding]; other site 267671003257 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671003258 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671003259 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 267671003260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 267671003261 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 267671003262 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 267671003263 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 267671003264 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671003265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671003266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671003267 ligand binding site [chemical binding]; other site 267671003268 flexible hinge region; other site 267671003269 PAS domain; Region: PAS_9; pfam13426 267671003270 PAS domain S-box; Region: sensory_box; TIGR00229 267671003271 PAS domain S-box; Region: sensory_box; TIGR00229 267671003272 PAS domain; Region: PAS_8; pfam13188 267671003273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671003274 dimer interface [polypeptide binding]; other site 267671003275 phosphorylation site [posttranslational modification] 267671003276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003277 ATP binding site [chemical binding]; other site 267671003278 Mg2+ binding site [ion binding]; other site 267671003279 G-X-G motif; other site 267671003280 Response regulator receiver domain; Region: Response_reg; pfam00072 267671003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003282 active site 267671003283 phosphorylation site [posttranslational modification] 267671003284 intermolecular recognition site; other site 267671003285 dimerization interface [polypeptide binding]; other site 267671003286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671003287 PAS domain; Region: PAS_9; pfam13426 267671003288 putative active site [active] 267671003289 heme pocket [chemical binding]; other site 267671003290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 267671003291 PAS fold; Region: PAS_4; pfam08448 267671003292 putative active site [active] 267671003293 heme pocket [chemical binding]; other site 267671003294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267671003295 Histidine kinase; Region: HisKA_2; pfam07568 267671003296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003297 ATP binding site [chemical binding]; other site 267671003298 Mg2+ binding site [ion binding]; other site 267671003299 G-X-G motif; other site 267671003300 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 267671003301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671003302 Walker A/P-loop; other site 267671003303 ATP binding site [chemical binding]; other site 267671003304 Q-loop/lid; other site 267671003305 ABC transporter signature motif; other site 267671003306 Walker B; other site 267671003307 D-loop; other site 267671003308 H-loop/switch region; other site 267671003309 ABC transporter; Region: ABC_tran_2; pfam12848 267671003310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 267671003311 FecR protein; Region: FecR; pfam04773 267671003312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671003313 dimerization interface [polypeptide binding]; other site 267671003314 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671003315 cyclase homology domain; Region: CHD; cd07302 267671003316 nucleotidyl binding site; other site 267671003317 metal binding site [ion binding]; metal-binding site 267671003318 dimer interface [polypeptide binding]; other site 267671003319 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 267671003320 active site 267671003321 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 267671003322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003323 ATP binding site [chemical binding]; other site 267671003324 Mg2+ binding site [ion binding]; other site 267671003325 G-X-G motif; other site 267671003326 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671003327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003328 active site 267671003329 phosphorylation site [posttranslational modification] 267671003330 intermolecular recognition site; other site 267671003331 PAS domain S-box; Region: sensory_box; TIGR00229 267671003332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671003333 putative active site [active] 267671003334 heme pocket [chemical binding]; other site 267671003335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267671003336 Histidine kinase; Region: HisKA_2; pfam07568 267671003337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003338 ATP binding site [chemical binding]; other site 267671003339 Mg2+ binding site [ion binding]; other site 267671003340 G-X-G motif; other site 267671003341 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 267671003342 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 267671003343 dimerization interface [polypeptide binding]; other site 267671003344 Response regulator receiver domain; Region: Response_reg; pfam00072 267671003345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003346 active site 267671003347 phosphorylation site [posttranslational modification] 267671003348 intermolecular recognition site; other site 267671003349 dimerization interface [polypeptide binding]; other site 267671003350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671003351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671003352 metal binding site [ion binding]; metal-binding site 267671003353 active site 267671003354 I-site; other site 267671003355 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 267671003356 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 267671003357 MOFRL family; Region: MOFRL; pfam05161 267671003358 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671003359 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671003360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671003361 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671003362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671003363 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671003364 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 267671003365 putative active site [active] 267671003366 putative catalytic site [active] 267671003367 putative DNA binding site [nucleotide binding]; other site 267671003368 putative phosphate binding site [ion binding]; other site 267671003369 metal binding site A [ion binding]; metal-binding site 267671003370 putative AP binding site [nucleotide binding]; other site 267671003371 putative metal binding site B [ion binding]; other site 267671003372 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 267671003373 histidinol dehydrogenase; Region: hisD; TIGR00069 267671003374 NAD binding site [chemical binding]; other site 267671003375 dimerization interface [polypeptide binding]; other site 267671003376 product binding site; other site 267671003377 substrate binding site [chemical binding]; other site 267671003378 zinc binding site [ion binding]; other site 267671003379 catalytic residues [active] 267671003380 pantoate--beta-alanine ligase; Region: panC; TIGR00018 267671003381 Pantoate-beta-alanine ligase; Region: PanC; cd00560 267671003382 active site 267671003383 ATP-binding site [chemical binding]; other site 267671003384 pantoate-binding site; other site 267671003385 HXXH motif; other site 267671003386 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 267671003387 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 267671003388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671003389 ATP binding site [chemical binding]; other site 267671003390 putative Mg++ binding site [ion binding]; other site 267671003391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671003392 nucleotide binding region [chemical binding]; other site 267671003393 ATP-binding site [chemical binding]; other site 267671003394 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 267671003395 Bacitracin resistance protein BacA; Region: BacA; pfam02673 267671003396 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 267671003397 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 267671003398 Bacterial sugar transferase; Region: Bac_transf; pfam02397 267671003399 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 267671003400 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 267671003401 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 267671003402 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 267671003403 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 267671003404 substrate binding site [chemical binding]; other site 267671003405 glutamase interaction surface [polypeptide binding]; other site 267671003406 PGAP1-like protein; Region: PGAP1; pfam07819 267671003407 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671003408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671003409 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 267671003410 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 267671003411 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 267671003412 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 267671003413 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 267671003414 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 267671003415 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 267671003416 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 267671003417 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 267671003418 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 267671003419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 267671003420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 267671003421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671003422 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671003423 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671003424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671003425 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671003426 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 267671003427 active site 267671003428 oxyanion hole [active] 267671003429 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671003430 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671003431 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 267671003432 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 267671003433 catalytic triad [active] 267671003434 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671003435 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 267671003436 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 267671003437 active site 267671003438 Int/Topo IB signature motif; other site 267671003439 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 267671003440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003441 ATP binding site [chemical binding]; other site 267671003442 Mg2+ binding site [ion binding]; other site 267671003443 G-X-G motif; other site 267671003444 TfoX N-terminal domain; Region: TfoX_N; pfam04993 267671003445 Protein of unknown function (DUF342); Region: DUF342; pfam03961 267671003446 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671003447 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671003448 ligand binding site [chemical binding]; other site 267671003449 flexible hinge region; other site 267671003450 putative switch regulator; other site 267671003451 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 267671003452 non-specific DNA interactions [nucleotide binding]; other site 267671003453 DNA binding site [nucleotide binding] 267671003454 sequence specific DNA binding site [nucleotide binding]; other site 267671003455 putative cAMP binding site [chemical binding]; other site 267671003456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003457 binding surface 267671003458 TPR motif; other site 267671003459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671003460 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 267671003461 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 267671003462 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 267671003463 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 267671003464 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 267671003465 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 267671003466 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267671003467 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 267671003468 Walker A/P-loop; other site 267671003469 ATP binding site [chemical binding]; other site 267671003470 Q-loop/lid; other site 267671003471 ABC transporter signature motif; other site 267671003472 Walker B; other site 267671003473 D-loop; other site 267671003474 H-loop/switch region; other site 267671003475 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671003476 anti sigma factor interaction site; other site 267671003477 regulatory phosphorylation site [posttranslational modification]; other site 267671003478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671003479 S-adenosylmethionine binding site [chemical binding]; other site 267671003480 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 267671003481 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 267671003482 active site 267671003483 Predicted membrane protein [Function unknown]; Region: COG3766 267671003484 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 267671003485 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 267671003486 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 267671003487 Leucine rich repeat; Region: LRR_8; pfam13855 267671003488 Leucine rich repeat; Region: LRR_8; pfam13855 267671003489 Leucine rich repeat; Region: LRR_8; pfam13855 267671003490 Leucine rich repeat; Region: LRR_8; pfam13855 267671003491 Leucine rich repeat; Region: LRR_8; pfam13855 267671003492 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 267671003493 outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327 267671003494 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 267671003495 Leucine rich repeat; Region: LRR_8; pfam13855 267671003496 Leucine rich repeat; Region: LRR_8; pfam13855 267671003497 Leucine rich repeat; Region: LRR_8; pfam13855 267671003498 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 267671003499 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 267671003500 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 267671003501 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 267671003502 active site 267671003503 catalytic residues [active] 267671003504 metal binding site [ion binding]; metal-binding site 267671003505 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671003506 GAF domain; Region: GAF; pfam01590 267671003507 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671003508 GAF domain; Region: GAF_3; pfam13492 267671003509 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671003510 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671003511 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 267671003512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267671003513 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671003514 anti sigma factor interaction site; other site 267671003515 regulatory phosphorylation site [posttranslational modification]; other site 267671003516 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 267671003517 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 267671003518 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 267671003519 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267671003520 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671003521 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 267671003522 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 267671003523 carboxyltransferase (CT) interaction site; other site 267671003524 biotinylation site [posttranslational modification]; other site 267671003525 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 267671003526 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 267671003527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003528 active site 267671003529 phosphorylation site [posttranslational modification] 267671003530 intermolecular recognition site; other site 267671003531 dimerization interface [polypeptide binding]; other site 267671003532 CheB methylesterase; Region: CheB_methylest; pfam01339 267671003533 CheD chemotactic sensory transduction; Region: CheD; cl00810 267671003534 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 267671003535 PAS domain; Region: PAS_10; pfam13596 267671003536 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 267671003537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 267671003538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671003539 dimer interface [polypeptide binding]; other site 267671003540 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 267671003541 putative CheW interface [polypeptide binding]; other site 267671003542 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 267671003543 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 267671003544 putative binding surface; other site 267671003545 active site 267671003546 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 267671003547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003548 ATP binding site [chemical binding]; other site 267671003549 Mg2+ binding site [ion binding]; other site 267671003550 G-X-G motif; other site 267671003551 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 267671003552 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671003553 anti sigma factor interaction site; other site 267671003554 regulatory phosphorylation site [posttranslational modification]; other site 267671003555 Response regulator receiver domain; Region: Response_reg; pfam00072 267671003556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003557 active site 267671003558 phosphorylation site [posttranslational modification] 267671003559 intermolecular recognition site; other site 267671003560 dimerization interface [polypeptide binding]; other site 267671003561 Response regulator receiver domain; Region: Response_reg; pfam00072 267671003562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003563 active site 267671003564 phosphorylation site [posttranslational modification] 267671003565 intermolecular recognition site; other site 267671003566 dimerization interface [polypeptide binding]; other site 267671003567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003568 ATP binding site [chemical binding]; other site 267671003569 Mg2+ binding site [ion binding]; other site 267671003570 G-X-G motif; other site 267671003571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671003572 PAS domain; Region: PAS_9; pfam13426 267671003573 putative active site [active] 267671003574 heme pocket [chemical binding]; other site 267671003575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671003576 dimer interface [polypeptide binding]; other site 267671003577 phosphorylation site [posttranslational modification] 267671003578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003579 ATP binding site [chemical binding]; other site 267671003580 Mg2+ binding site [ion binding]; other site 267671003581 G-X-G motif; other site 267671003582 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 267671003583 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 267671003584 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671003585 flagellin; Provisional; Region: PRK12804 267671003586 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 267671003587 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 267671003588 flagellin; Provisional; Region: PRK12804 267671003589 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 267671003590 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 267671003591 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 267671003592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671003593 putative substrate translocation pore; other site 267671003594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671003595 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 267671003596 NlpC/P60 family; Region: NLPC_P60; pfam00877 267671003597 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 267671003598 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 267671003599 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 267671003600 putative ribose interaction site [chemical binding]; other site 267671003601 putative ADP binding site [chemical binding]; other site 267671003602 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 267671003603 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 267671003604 active site 267671003605 nucleotide binding site [chemical binding]; other site 267671003606 HIGH motif; other site 267671003607 KMSKS motif; other site 267671003608 CTP synthetase; Validated; Region: pyrG; PRK05380 267671003609 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 267671003610 Catalytic site [active] 267671003611 active site 267671003612 UTP binding site [chemical binding]; other site 267671003613 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 267671003614 active site 267671003615 putative oxyanion hole; other site 267671003616 catalytic triad [active] 267671003617 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 267671003618 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 267671003619 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 267671003620 OstA-like protein; Region: OstA; cl00844 267671003621 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 267671003622 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 267671003623 Walker A/P-loop; other site 267671003624 ATP binding site [chemical binding]; other site 267671003625 Q-loop/lid; other site 267671003626 ABC transporter signature motif; other site 267671003627 Walker B; other site 267671003628 D-loop; other site 267671003629 H-loop/switch region; other site 267671003630 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 267671003631 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 267671003632 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 267671003633 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 267671003634 HPr kinase/phosphorylase; Provisional; Region: PRK05428 267671003635 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 267671003636 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 267671003637 Hpr binding site; other site 267671003638 active site 267671003639 homohexamer subunit interaction site [polypeptide binding]; other site 267671003640 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 267671003641 regulatory protein interface [polypeptide binding]; other site 267671003642 active site 267671003643 regulatory phosphorylation site [posttranslational modification]; other site 267671003644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671003645 dimerization interface [polypeptide binding]; other site 267671003646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671003647 dimer interface [polypeptide binding]; other site 267671003648 phosphorylation site [posttranslational modification] 267671003649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671003650 ATP binding site [chemical binding]; other site 267671003651 Mg2+ binding site [ion binding]; other site 267671003652 G-X-G motif; other site 267671003653 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 267671003654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671003655 active site 267671003656 phosphorylation site [posttranslational modification] 267671003657 intermolecular recognition site; other site 267671003658 dimerization interface [polypeptide binding]; other site 267671003659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671003660 Walker A motif; other site 267671003661 ATP binding site [chemical binding]; other site 267671003662 Walker B motif; other site 267671003663 arginine finger; other site 267671003664 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 267671003665 primosome assembly protein PriA; Validated; Region: PRK05580 267671003666 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671003667 ATP binding site [chemical binding]; other site 267671003668 putative Mg++ binding site [ion binding]; other site 267671003669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 267671003670 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 267671003671 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 267671003672 putative active site [active] 267671003673 substrate binding site [chemical binding]; other site 267671003674 putative cosubstrate binding site; other site 267671003675 catalytic site [active] 267671003676 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 267671003677 substrate binding site [chemical binding]; other site 267671003678 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 267671003679 PASTA domain; Region: PASTA; pfam03793 267671003680 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 267671003681 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 267671003682 substrate binding site [chemical binding]; other site 267671003683 hexamer interface [polypeptide binding]; other site 267671003684 metal binding site [ion binding]; metal-binding site 267671003685 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 267671003686 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 267671003687 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 267671003688 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590 267671003689 RimM N-terminal domain; Region: RimM; pfam01782 267671003690 PRC-barrel domain; Region: PRC; pfam05239 267671003691 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Provisional; Region: trmD; PRK14599 267671003692 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 267671003693 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 267671003694 RNA/DNA hybrid binding site [nucleotide binding]; other site 267671003695 active site 267671003696 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 267671003697 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 267671003698 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 267671003699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671003700 Zn2+ binding site [ion binding]; other site 267671003701 Mg2+ binding site [ion binding]; other site 267671003702 hypothetical protein; Reviewed; Region: PRK12497 267671003703 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 267671003704 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 267671003705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671003706 Walker A motif; other site 267671003707 ATP binding site [chemical binding]; other site 267671003708 Walker B motif; other site 267671003709 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 267671003710 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671003711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 267671003712 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671003713 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 267671003714 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 267671003715 type II secretion system protein D; Region: type_II_gspD; TIGR02517 267671003716 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 267671003717 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 267671003718 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 267671003719 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 267671003720 type II secretion system protein E; Region: type_II_gspE; TIGR02533 267671003721 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 267671003722 Walker A motif; other site 267671003723 ATP binding site [chemical binding]; other site 267671003724 Walker B motif; other site 267671003725 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 267671003726 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 267671003727 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 267671003728 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 267671003729 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 267671003730 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 267671003731 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 267671003732 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 267671003733 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 267671003734 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 267671003735 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 267671003736 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 267671003737 Cell division protein FtsA; Region: FtsA; pfam14450 267671003738 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 267671003739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671003740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671003741 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 267671003742 active site 1 [active] 267671003743 dimer interface [polypeptide binding]; other site 267671003744 hexamer interface [polypeptide binding]; other site 267671003745 active site 2 [active] 267671003746 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 267671003747 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 267671003748 NAD(P) binding site [chemical binding]; other site 267671003749 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 267671003750 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 267671003751 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 267671003752 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 267671003753 active site 267671003754 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 267671003755 TSCPD domain; Region: TSCPD; pfam12637 267671003756 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14069 267671003757 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 267671003758 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 267671003759 generic binding surface II; other site 267671003760 generic binding surface I; other site 267671003761 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 267671003762 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 267671003763 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 267671003764 Uncharacterized conserved protein [Function unknown]; Region: COG4850 267671003765 Smr domain; Region: Smr; pfam01713 267671003766 (R)-citramalate synthase; Provisional; Region: PRK09389 267671003767 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 267671003768 active site 267671003769 catalytic residues [active] 267671003770 metal binding site [ion binding]; metal-binding site 267671003771 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 267671003772 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 267671003773 putative active site [active] 267671003774 catalytic residue [active] 267671003775 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 267671003776 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 267671003777 active site 267671003778 Int/Topo IB signature motif; other site 267671003779 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 267671003780 active site 267671003781 HslU subunit interaction site [polypeptide binding]; other site 267671003782 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 267671003783 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 267671003784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671003785 Walker A motif; other site 267671003786 ATP binding site [chemical binding]; other site 267671003787 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 267671003788 Walker B motif; other site 267671003789 arginine finger; other site 267671003790 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 267671003791 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 267671003792 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 267671003793 E3 interaction surface; other site 267671003794 lipoyl attachment site [posttranslational modification]; other site 267671003795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 267671003796 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 267671003797 putative active site [active] 267671003798 putative metal binding site [ion binding]; other site 267671003799 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 267671003800 active site 267671003801 metal binding site [ion binding]; metal-binding site 267671003802 Domain of unknown function DUF59; Region: DUF59; pfam01883 267671003803 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 267671003804 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 267671003805 Walker A motif; other site 267671003806 aromatic acid decarboxylase; Validated; Region: PRK05920 267671003807 Flavoprotein; Region: Flavoprotein; pfam02441 267671003808 prenyltransferase; Reviewed; Region: ubiA; PRK12886 267671003809 UbiA prenyltransferase family; Region: UbiA; pfam01040 267671003810 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 267671003811 dinuclear metal binding motif [ion binding]; other site 267671003812 GTP-binding protein YchF; Reviewed; Region: PRK09601 267671003813 YchF GTPase; Region: YchF; cd01900 267671003814 G1 box; other site 267671003815 GTP/Mg2+ binding site [chemical binding]; other site 267671003816 Switch I region; other site 267671003817 G2 box; other site 267671003818 Switch II region; other site 267671003819 G3 box; other site 267671003820 G4 box; other site 267671003821 G5 box; other site 267671003822 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 267671003823 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 267671003824 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 267671003825 minor groove reading motif; other site 267671003826 helix-hairpin-helix signature motif; other site 267671003827 substrate binding pocket [chemical binding]; other site 267671003828 active site 267671003829 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 267671003830 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 267671003831 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 267671003832 NADP binding site [chemical binding]; other site 267671003833 homopentamer interface [polypeptide binding]; other site 267671003834 substrate binding site [chemical binding]; other site 267671003835 active site 267671003836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671003837 dimerization interface [polypeptide binding]; other site 267671003838 putative DNA binding site [nucleotide binding]; other site 267671003839 putative Zn2+ binding site [ion binding]; other site 267671003840 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 267671003841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671003842 NAD(P) binding site [chemical binding]; other site 267671003843 active site 267671003844 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 267671003845 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 267671003846 Walker A/P-loop; other site 267671003847 ATP binding site [chemical binding]; other site 267671003848 Q-loop/lid; other site 267671003849 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 267671003850 ABC transporter signature motif; other site 267671003851 Walker B; other site 267671003852 D-loop; other site 267671003853 H-loop/switch region; other site 267671003854 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 267671003855 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 267671003856 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 267671003857 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 267671003858 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 267671003859 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 267671003860 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 267671003861 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 267671003862 Surface antigen; Region: Bac_surface_Ag; pfam01103 267671003863 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 267671003864 Part of AAA domain; Region: AAA_19; pfam13245 267671003865 Family description; Region: UvrD_C_2; pfam13538 267671003866 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 267671003867 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 267671003868 active site 267671003869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671003870 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 267671003871 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 267671003872 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 267671003873 catalytic residues [active] 267671003874 long-chain acyl-CoA synthetase; Region: PLN02736 267671003875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 267671003876 acyl-activating enzyme (AAE) consensus motif; other site 267671003877 CoA binding site [chemical binding]; other site 267671003878 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 267671003879 putative AMP binding site [chemical binding]; other site 267671003880 putative active site [active] 267671003881 putative CoA binding site [chemical binding]; other site 267671003882 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 267671003883 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 267671003884 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 267671003885 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 267671003886 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 267671003887 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 267671003888 C factor cell-cell signaling protein; Provisional; Region: PRK09009 267671003889 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 267671003890 NADP binding site [chemical binding]; other site 267671003891 homodimer interface [polypeptide binding]; other site 267671003892 active site 267671003893 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 267671003894 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 267671003895 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 267671003896 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 267671003897 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 267671003898 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 267671003899 FecR protein; Region: FecR; pfam04773 267671003900 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671003901 lipoyl synthase; Provisional; Region: PRK05481 267671003902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671003903 FeS/SAM binding site; other site 267671003904 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 267671003905 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267671003906 RNA binding surface [nucleotide binding]; other site 267671003907 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 267671003908 active site 267671003909 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 267671003910 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 267671003911 active site 267671003912 intersubunit interactions; other site 267671003913 catalytic residue [active] 267671003914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 267671003915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 267671003916 purine monophosphate binding site [chemical binding]; other site 267671003917 dimer interface [polypeptide binding]; other site 267671003918 putative catalytic residues [active] 267671003919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 267671003920 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 267671003921 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 267671003922 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 267671003923 active site 267671003924 substrate binding site [chemical binding]; other site 267671003925 cosubstrate binding site; other site 267671003926 catalytic site [active] 267671003927 Flagellar protein FliS; Region: FliS; cl00654 267671003928 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 267671003929 HSP70 interaction site [polypeptide binding]; other site 267671003930 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 267671003931 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 267671003932 active site 267671003933 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 267671003934 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 267671003935 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 267671003936 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671003937 Zn2+ binding site [ion binding]; other site 267671003938 Mg2+ binding site [ion binding]; other site 267671003939 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 267671003940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671003941 binding surface 267671003942 TPR motif; other site 267671003943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003944 TPR motif; other site 267671003945 binding surface 267671003946 TPR repeat; Region: TPR_11; pfam13414 267671003947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003948 binding surface 267671003949 TPR motif; other site 267671003950 TPR repeat; Region: TPR_11; pfam13414 267671003951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671003952 binding surface 267671003953 TPR motif; other site 267671003954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671003955 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 267671003956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671003957 substrate binding site [chemical binding]; other site 267671003958 oxyanion hole (OAH) forming residues; other site 267671003959 trimer interface [polypeptide binding]; other site 267671003960 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671003961 Ankyrin repeat; Region: Ank; pfam00023 267671003962 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671003963 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671003964 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671003965 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671003966 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671003967 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 267671003968 FAD binding domain; Region: FAD_binding_4; pfam01565 267671003969 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 267671003970 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 267671003971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671003972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671003973 Protein of unknown function (DUF962); Region: DUF962; cl01879 267671003974 YacP-like NYN domain; Region: NYN_YacP; pfam05991 267671003975 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 267671003976 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671003977 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671003978 NAD-dependent deacetylase; Provisional; Region: PRK00481 267671003979 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 267671003980 NAD+ binding site [chemical binding]; other site 267671003981 substrate binding site [chemical binding]; other site 267671003982 Zn binding site [ion binding]; other site 267671003983 DJ-1 family protein; Region: not_thiJ; TIGR01383 267671003984 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 267671003985 conserved cys residue [active] 267671003986 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 267671003987 active site 267671003988 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 267671003989 active site 267671003990 Zn binding site [ion binding]; other site 267671003991 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 267671003992 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 267671003993 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671003994 dimer interface [polypeptide binding]; other site 267671003995 putative CheW interface [polypeptide binding]; other site 267671003996 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 267671003997 hydrophobic ligand binding site; other site 267671003998 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 267671003999 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671004000 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 267671004001 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 267671004002 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 267671004003 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 267671004004 active site 267671004005 HIGH motif; other site 267671004006 dimer interface [polypeptide binding]; other site 267671004007 KMSKS motif; other site 267671004008 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 267671004009 RNA binding surface [nucleotide binding]; other site 267671004010 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 267671004011 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 267671004012 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 267671004013 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 267671004014 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 267671004015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671004016 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 267671004017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671004018 DNA binding residues [nucleotide binding] 267671004019 CHC2 zinc finger; Region: zf-CHC2; pfam01807 267671004020 DNA primase; Validated; Region: dnaG; PRK05667 267671004021 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 267671004022 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 267671004023 active site 267671004024 metal binding site [ion binding]; metal-binding site 267671004025 interdomain interaction site; other site 267671004026 Yqey-like protein; Region: YqeY; pfam09424 267671004027 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 267671004028 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 267671004029 AMP binding site [chemical binding]; other site 267671004030 metal binding site [ion binding]; metal-binding site 267671004031 active site 267671004032 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671004033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004034 active site 267671004035 phosphorylation site [posttranslational modification] 267671004036 intermolecular recognition site; other site 267671004037 dimerization interface [polypeptide binding]; other site 267671004038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671004039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004040 dimer interface [polypeptide binding]; other site 267671004041 phosphorylation site [posttranslational modification] 267671004042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004043 ATP binding site [chemical binding]; other site 267671004044 G-X-G motif; other site 267671004045 PAS domain; Region: PAS; smart00091 267671004046 PAS fold; Region: PAS_4; pfam08448 267671004047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671004048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004049 dimer interface [polypeptide binding]; other site 267671004050 phosphorylation site [posttranslational modification] 267671004051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004052 ATP binding site [chemical binding]; other site 267671004053 Mg2+ binding site [ion binding]; other site 267671004054 G-X-G motif; other site 267671004055 Response regulator receiver domain; Region: Response_reg; pfam00072 267671004056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004057 active site 267671004058 phosphorylation site [posttranslational modification] 267671004059 intermolecular recognition site; other site 267671004060 dimerization interface [polypeptide binding]; other site 267671004061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004062 dimer interface [polypeptide binding]; other site 267671004063 phosphorylation site [posttranslational modification] 267671004064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004065 ATP binding site [chemical binding]; other site 267671004066 Mg2+ binding site [ion binding]; other site 267671004067 G-X-G motif; other site 267671004068 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 267671004069 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 267671004070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 267671004071 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 267671004072 Soluble P-type ATPase [General function prediction only]; Region: COG4087 267671004073 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 267671004074 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 267671004075 MgtE intracellular N domain; Region: MgtE_N; pfam03448 267671004076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 267671004077 Divalent cation transporter; Region: MgtE; pfam01769 267671004078 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 267671004079 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671004080 ligand binding site [chemical binding]; other site 267671004081 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 267671004082 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671004083 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 267671004084 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 267671004085 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 267671004086 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 267671004087 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 267671004088 active site 267671004089 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 267671004090 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 267671004091 tandem repeat interface [polypeptide binding]; other site 267671004092 oligomer interface [polypeptide binding]; other site 267671004093 active site residues [active] 267671004094 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 267671004095 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 267671004096 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 267671004097 active site 267671004098 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 267671004099 2-isopropylmalate synthase; Validated; Region: PRK00915 267671004100 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 267671004101 active site 267671004102 catalytic residues [active] 267671004103 metal binding site [ion binding]; metal-binding site 267671004104 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 267671004105 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 267671004106 amidase catalytic site [active] 267671004107 Zn binding residues [ion binding]; other site 267671004108 substrate binding site [chemical binding]; other site 267671004109 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 267671004110 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 267671004111 active site 267671004112 FMN binding site [chemical binding]; other site 267671004113 2,4-decadienoyl-CoA binding site; other site 267671004114 catalytic residue [active] 267671004115 4Fe-4S cluster binding site [ion binding]; other site 267671004116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 267671004117 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671004118 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 267671004119 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 267671004120 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 267671004121 Part of AAA domain; Region: AAA_19; pfam13245 267671004122 Family description; Region: UvrD_C_2; pfam13538 267671004123 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 267671004124 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 267671004125 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 267671004126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 267671004127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671004128 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 267671004129 Walker A motif; other site 267671004130 ATP binding site [chemical binding]; other site 267671004131 Walker B motif; other site 267671004132 arginine finger; other site 267671004133 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 267671004134 Transglycosylase; Region: Transgly; pfam00912 267671004135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 267671004136 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 267671004137 MG2 domain; Region: A2M_N; pfam01835 267671004138 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 267671004139 Alpha-2-macroglobulin family; Region: A2M; pfam00207 267671004140 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 267671004141 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 267671004142 recombinase A; Provisional; Region: recA; PRK09354 267671004143 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 267671004144 hexamer interface [polypeptide binding]; other site 267671004145 Walker A motif; other site 267671004146 ATP binding site [chemical binding]; other site 267671004147 Walker B motif; other site 267671004148 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 267671004149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 267671004150 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 267671004151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 267671004152 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 267671004153 acyl-activating enzyme (AAE) consensus motif; other site 267671004154 putative AMP binding site [chemical binding]; other site 267671004155 putative active site [active] 267671004156 putative CoA binding site [chemical binding]; other site 267671004157 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 267671004158 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671004159 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671004160 ligand binding site [chemical binding]; other site 267671004161 flexible hinge region; other site 267671004162 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 267671004163 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 267671004164 nucleophile elbow; other site 267671004165 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 267671004166 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 267671004167 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 267671004168 putative active site [active] 267671004169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671004170 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 267671004171 putative ADP-binding pocket [chemical binding]; other site 267671004172 O-Antigen ligase; Region: Wzy_C; pfam04932 267671004173 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 267671004174 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 267671004175 putative active site [active] 267671004176 catalytic site [active] 267671004177 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 267671004178 putative active site [active] 267671004179 catalytic site [active] 267671004180 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 267671004181 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 267671004182 GIY-YIG motif/motif A; other site 267671004183 active site 267671004184 catalytic site [active] 267671004185 putative DNA binding site [nucleotide binding]; other site 267671004186 metal binding site [ion binding]; metal-binding site 267671004187 UvrB/uvrC motif; Region: UVR; pfam02151 267671004188 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 267671004189 Helix-hairpin-helix motif; Region: HHH; pfam00633 267671004190 RF-1 domain; Region: RF-1; pfam00472 267671004191 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 267671004192 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 267671004193 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 267671004194 minor groove reading motif; other site 267671004195 helix-hairpin-helix signature motif; other site 267671004196 substrate binding pocket [chemical binding]; other site 267671004197 active site 267671004198 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 267671004199 transaminase; Validated; Region: PRK07324 267671004200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671004201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004202 homodimer interface [polypeptide binding]; other site 267671004203 catalytic residue [active] 267671004204 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 267671004205 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 267671004206 active site 267671004207 substrate binding site [chemical binding]; other site 267671004208 metal binding site [ion binding]; metal-binding site 267671004209 acetylornithine aminotransferase; Provisional; Region: PRK02627 267671004210 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 267671004211 inhibitor-cofactor binding pocket; inhibition site 267671004212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004213 catalytic residue [active] 267671004214 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 267671004215 tartrate dehydrogenase; Region: TTC; TIGR02089 267671004216 Response regulator receiver domain; Region: Response_reg; pfam00072 267671004217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004218 active site 267671004219 phosphorylation site [posttranslational modification] 267671004220 intermolecular recognition site; other site 267671004221 dimerization interface [polypeptide binding]; other site 267671004222 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 267671004223 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 267671004224 active site 267671004225 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 267671004226 MutS domain I; Region: MutS_I; pfam01624 267671004227 MutS domain II; Region: MutS_II; pfam05188 267671004228 MutS domain III; Region: MutS_III; pfam05192 267671004229 MutS domain V; Region: MutS_V; pfam00488 267671004230 Walker A/P-loop; other site 267671004231 ATP binding site [chemical binding]; other site 267671004232 Q-loop/lid; other site 267671004233 ABC transporter signature motif; other site 267671004234 Walker B; other site 267671004235 D-loop; other site 267671004236 H-loop/switch region; other site 267671004237 phosphoserine phosphatase SerB; Region: serB; TIGR00338 267671004238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267671004239 motif II; other site 267671004240 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 267671004241 active site 267671004242 catalytic triad [active] 267671004243 oxyanion hole [active] 267671004244 biotin synthase; Region: bioB; TIGR00433 267671004245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671004246 FeS/SAM binding site; other site 267671004247 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 267671004248 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 267671004249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 267671004250 inhibitor-cofactor binding pocket; inhibition site 267671004251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004252 catalytic residue [active] 267671004253 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 267671004254 AAA domain; Region: AAA_26; pfam13500 267671004255 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 267671004256 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 267671004257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671004258 catalytic residue [active] 267671004259 malate dehydrogenase; Provisional; Region: PRK05442 267671004260 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 267671004261 NAD(P) binding site [chemical binding]; other site 267671004262 dimer interface [polypeptide binding]; other site 267671004263 malate binding site [chemical binding]; other site 267671004264 Thioredoxin; Region: Thioredoxin_4; pfam13462 267671004265 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 267671004266 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 267671004267 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 267671004268 Na binding site [ion binding]; other site 267671004269 PGAP1-like protein; Region: PGAP1; pfam07819 267671004270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671004271 aspartate aminotransferase; Provisional; Region: PRK05764 267671004272 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004274 homodimer interface [polypeptide binding]; other site 267671004275 catalytic residue [active] 267671004276 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 267671004277 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 267671004278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 267671004279 ATP binding site [chemical binding]; other site 267671004280 putative Mg++ binding site [ion binding]; other site 267671004281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671004282 nucleotide binding region [chemical binding]; other site 267671004283 ATP-binding site [chemical binding]; other site 267671004284 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 267671004285 active site 267671004286 catalytic residues [active] 267671004287 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 267671004288 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 267671004289 tandem repeat interface [polypeptide binding]; other site 267671004290 oligomer interface [polypeptide binding]; other site 267671004291 active site residues [active] 267671004292 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671004293 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671004294 glycerol kinase; Provisional; Region: glpK; PRK00047 267671004295 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 267671004296 N- and C-terminal domain interface [polypeptide binding]; other site 267671004297 active site 267671004298 MgATP binding site [chemical binding]; other site 267671004299 catalytic site [active] 267671004300 metal binding site [ion binding]; metal-binding site 267671004301 glycerol binding site [chemical binding]; other site 267671004302 homotetramer interface [polypeptide binding]; other site 267671004303 homodimer interface [polypeptide binding]; other site 267671004304 FBP binding site [chemical binding]; other site 267671004305 protein IIAGlc interface [polypeptide binding]; other site 267671004306 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 267671004307 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671004308 anti sigma factor interaction site; other site 267671004309 regulatory phosphorylation site [posttranslational modification]; other site 267671004310 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 267671004311 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 267671004312 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267671004313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267671004314 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 267671004315 Walker A/P-loop; other site 267671004316 ATP binding site [chemical binding]; other site 267671004317 Q-loop/lid; other site 267671004318 ABC transporter signature motif; other site 267671004319 Walker B; other site 267671004320 D-loop; other site 267671004321 H-loop/switch region; other site 267671004322 inner membrane transport permease; Provisional; Region: PRK15066 267671004323 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 267671004324 BolA-like protein; Region: BolA; pfam01722 267671004325 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 267671004326 putative GSH binding site [chemical binding]; other site 267671004327 catalytic residues [active] 267671004328 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 267671004329 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 267671004330 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 267671004331 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671004332 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671004333 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 267671004334 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 267671004335 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 267671004336 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 267671004337 Clp amino terminal domain; Region: Clp_N; pfam02861 267671004338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671004339 Walker A motif; other site 267671004340 ATP binding site [chemical binding]; other site 267671004341 Walker B motif; other site 267671004342 arginine finger; other site 267671004343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671004344 Walker A motif; other site 267671004345 ATP binding site [chemical binding]; other site 267671004346 Walker B motif; other site 267671004347 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 267671004348 Uncharacterized conserved protein [Function unknown]; Region: COG2127 267671004349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 267671004350 Protein of unknown function, DUF482; Region: DUF482; pfam04339 267671004351 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671004352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671004353 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671004354 DNA binding residues [nucleotide binding] 267671004355 AAA domain; Region: AAA_11; pfam13086 267671004356 Part of AAA domain; Region: AAA_19; pfam13245 267671004357 AAA domain; Region: AAA_12; pfam13087 267671004358 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 267671004359 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 267671004360 dimer interface [polypeptide binding]; other site 267671004361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004362 catalytic residue [active] 267671004363 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 267671004364 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 267671004365 substrate binding site [chemical binding]; other site 267671004366 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 267671004367 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 267671004368 substrate binding site [chemical binding]; other site 267671004369 ligand binding site [chemical binding]; other site 267671004370 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 267671004371 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 267671004372 phosphopeptide binding site; other site 267671004373 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 267671004374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 267671004375 Walker A/P-loop; other site 267671004376 ATP binding site [chemical binding]; other site 267671004377 Q-loop/lid; other site 267671004378 ABC transporter signature motif; other site 267671004379 Walker B; other site 267671004380 D-loop; other site 267671004381 H-loop/switch region; other site 267671004382 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 267671004383 dimer interface [polypeptide binding]; other site 267671004384 active site 267671004385 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 267671004386 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 267671004387 putative metal binding site; other site 267671004388 GMP synthase; Reviewed; Region: guaA; PRK00074 267671004389 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 267671004390 AMP/PPi binding site [chemical binding]; other site 267671004391 candidate oxyanion hole; other site 267671004392 catalytic triad [active] 267671004393 potential glutamine specificity residues [chemical binding]; other site 267671004394 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 267671004395 ATP Binding subdomain [chemical binding]; other site 267671004396 Ligand Binding sites [chemical binding]; other site 267671004397 Dimerization subdomain; other site 267671004398 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 267671004399 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 267671004400 Uncharacterized conserved protein [Function unknown]; Region: COG4095 267671004401 FecR protein; Region: FecR; pfam04773 267671004402 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 267671004403 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 267671004404 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 267671004405 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 267671004406 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 267671004407 active site 267671004408 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 267671004409 argininosuccinate lyase; Provisional; Region: PRK00855 267671004410 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 267671004411 active sites [active] 267671004412 tetramer interface [polypeptide binding]; other site 267671004413 Haem-binding domain; Region: Haem_bd; pfam14376 267671004414 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 267671004415 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 267671004416 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 267671004417 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 267671004418 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 267671004419 flagellar motor switch protein FliN; Region: fliN; TIGR02480 267671004420 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 267671004421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671004422 Walker A motif; other site 267671004423 ATP binding site [chemical binding]; other site 267671004424 Walker B motif; other site 267671004425 arginine finger; other site 267671004426 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 267671004427 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 267671004428 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 267671004429 homodimer interface [polypeptide binding]; other site 267671004430 substrate-cofactor binding pocket; other site 267671004431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004432 catalytic residue [active] 267671004433 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 267671004434 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 267671004435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 267671004436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671004437 S-adenosylmethionine binding site [chemical binding]; other site 267671004438 D-alanyl-alanine synthetase A; Provisional; Region: PRK14572 267671004439 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 267671004440 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671004441 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 267671004442 Permease; Region: Permease; pfam02405 267671004443 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 267671004444 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 267671004445 Walker A/P-loop; other site 267671004446 ATP binding site [chemical binding]; other site 267671004447 Q-loop/lid; other site 267671004448 ABC transporter signature motif; other site 267671004449 Walker B; other site 267671004450 D-loop; other site 267671004451 H-loop/switch region; other site 267671004452 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 267671004453 mce related protein; Region: MCE; pfam02470 267671004454 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 267671004455 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 267671004456 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 267671004457 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 267671004458 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 267671004459 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 267671004460 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 267671004461 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267671004462 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 267671004463 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 267671004464 active site 267671004465 homodimer interface [polypeptide binding]; other site 267671004466 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 267671004467 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 267671004468 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 267671004469 Mg++ binding site [ion binding]; other site 267671004470 putative catalytic motif [active] 267671004471 putative substrate binding site [chemical binding]; other site 267671004472 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 267671004473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 267671004474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267671004475 Cell division protein FtsL; Region: FtsL; cl11433 267671004476 MraW methylase family; Region: Methyltransf_5; cl17771 267671004477 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 267671004478 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 267671004479 nucleotide binding site/active site [active] 267671004480 HIT family signature motif; other site 267671004481 catalytic residue [active] 267671004482 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 267671004483 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 267671004484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671004485 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 267671004486 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 267671004487 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 267671004488 Protein of unknown function (DUF1562); Region: DUF1562; pfam07601 267671004489 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671004490 TIGR02453 family protein; Region: TIGR02453 267671004491 Peptidase family M48; Region: Peptidase_M48; cl12018 267671004492 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 267671004493 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 267671004494 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 267671004495 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 267671004496 Cytochrome c; Region: Cytochrom_C; cl11414 267671004497 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 267671004498 flagellin; Provisional; Region: PRK12804 267671004499 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 267671004500 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 267671004501 flagellin; Provisional; Region: PRK12804 267671004502 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 267671004503 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 267671004504 inner membrane protein; Provisional; Region: PRK11715 267671004505 sensory histidine kinase CreC; Provisional; Region: PRK11100 267671004506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004507 ATP binding site [chemical binding]; other site 267671004508 Mg2+ binding site [ion binding]; other site 267671004509 G-X-G motif; other site 267671004510 DNA-binding response regulator CreB; Provisional; Region: PRK11083 267671004511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004512 active site 267671004513 phosphorylation site [posttranslational modification] 267671004514 intermolecular recognition site; other site 267671004515 dimerization interface [polypeptide binding]; other site 267671004516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267671004517 DNA binding site [nucleotide binding] 267671004518 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 267671004519 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 267671004520 tetramer interface [polypeptide binding]; other site 267671004521 TPP-binding site [chemical binding]; other site 267671004522 heterodimer interface [polypeptide binding]; other site 267671004523 phosphorylation loop region [posttranslational modification] 267671004524 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 267671004525 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 267671004526 alpha subunit interface [polypeptide binding]; other site 267671004527 TPP binding site [chemical binding]; other site 267671004528 heterodimer interface [polypeptide binding]; other site 267671004529 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267671004530 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 267671004531 FliG C-terminal domain; Region: FliG_C; pfam01706 267671004532 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671004533 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 267671004534 translation initiation factor IF-2B subunit delta; Provisional; Region: PRK08535 267671004535 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 267671004536 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 267671004537 putative active site [active] 267671004538 putative metal binding site [ion binding]; other site 267671004539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671004540 active site 267671004541 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 267671004542 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 267671004543 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 267671004544 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 267671004545 dimer interface [polypeptide binding]; other site 267671004546 putative anticodon binding site; other site 267671004547 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 267671004548 motif 1; other site 267671004549 active site 267671004550 motif 2; other site 267671004551 motif 3; other site 267671004552 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 267671004553 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 267671004554 thiamine phosphate binding site [chemical binding]; other site 267671004555 active site 267671004556 pyrophosphate binding site [ion binding]; other site 267671004557 RNA methyltransferase, RsmE family; Region: TIGR00046 267671004558 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 267671004559 inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314 267671004560 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 267671004561 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 267671004562 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 267671004563 active site 267671004564 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 267671004565 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671004566 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 267671004567 O-Antigen ligase; Region: Wzy_C; pfam04932 267671004568 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 267671004569 Ligand binding site; other site 267671004570 Putative Catalytic site; other site 267671004571 DXD motif; other site 267671004572 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 267671004573 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 267671004574 FAD binding domain; Region: FAD_binding_4; pfam01565 267671004575 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 267671004576 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 267671004577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671004578 NAD(P) binding site [chemical binding]; other site 267671004579 active site 267671004580 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 267671004581 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 267671004582 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 267671004583 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 267671004584 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 267671004585 active site 267671004586 NTP binding site [chemical binding]; other site 267671004587 metal binding triad [ion binding]; metal-binding site 267671004588 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 267671004589 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 267671004590 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 267671004591 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 267671004592 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 267671004593 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 267671004594 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 267671004595 HlyD family secretion protein; Region: HlyD_3; pfam13437 267671004596 Outer membrane efflux protein; Region: OEP; pfam02321 267671004597 Outer membrane efflux protein; Region: OEP; pfam02321 267671004598 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 267671004599 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 267671004600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 267671004601 nucleotide binding region [chemical binding]; other site 267671004602 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 267671004603 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 267671004604 catalytic triad [active] 267671004605 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 267671004606 catalytic residues [active] 267671004607 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 267671004608 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 267671004609 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 267671004610 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 267671004611 oligomer interface [polypeptide binding]; other site 267671004612 active site residues [active] 267671004613 Septum formation initiator; Region: DivIC; pfam04977 267671004614 enolase; Provisional; Region: eno; PRK00077 267671004615 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 267671004616 dimer interface [polypeptide binding]; other site 267671004617 metal binding site [ion binding]; metal-binding site 267671004618 substrate binding pocket [chemical binding]; other site 267671004619 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 267671004620 Response regulator receiver domain; Region: Response_reg; pfam00072 267671004621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004622 active site 267671004623 phosphorylation site [posttranslational modification] 267671004624 intermolecular recognition site; other site 267671004625 dimerization interface [polypeptide binding]; other site 267671004626 HEAT repeats; Region: HEAT_2; pfam13646 267671004627 HEAT repeats; Region: HEAT_2; pfam13646 267671004628 HEAT repeats; Region: HEAT_2; pfam13646 267671004629 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671004630 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 267671004631 Bifunctional nuclease; Region: DNase-RNase; pfam02577 267671004632 UvrB/uvrC motif; Region: UVR; pfam02151 267671004633 major vault protein; Provisional; Region: PTZ00491 267671004634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671004635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267671004636 putative substrate translocation pore; other site 267671004637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671004638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671004639 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671004640 active site 267671004641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 267671004642 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671004643 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671004644 ligand binding site [chemical binding]; other site 267671004645 flexible hinge region; other site 267671004646 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671004647 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671004648 ligand binding site [chemical binding]; other site 267671004649 flexible hinge region; other site 267671004650 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 267671004651 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 267671004652 catalytic residues [active] 267671004653 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 267671004654 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 267671004655 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671004656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 267671004657 MORN repeat; Region: MORN; cl14787 267671004658 MORN repeat; Region: MORN; cl14787 267671004659 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 267671004660 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 267671004661 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 267671004662 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 267671004663 glycogen binding site [chemical binding]; other site 267671004664 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 267671004665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671004666 binding surface 267671004667 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671004668 TPR motif; other site 267671004669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671004670 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671004671 binding surface 267671004672 TPR motif; other site 267671004673 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 267671004674 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 267671004675 ligand binding site [chemical binding]; other site 267671004676 NAD binding site [chemical binding]; other site 267671004677 tetramer interface [polypeptide binding]; other site 267671004678 catalytic site [active] 267671004679 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 267671004680 L-serine binding site [chemical binding]; other site 267671004681 ACT domain interface; other site 267671004682 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 267671004683 CoenzymeA binding site [chemical binding]; other site 267671004684 subunit interaction site [polypeptide binding]; other site 267671004685 PHB binding site; other site 267671004686 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671004687 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671004688 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 267671004689 catalytic site [active] 267671004690 Domain of unknown function (DUF309); Region: DUF309; pfam03745 267671004691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267671004692 active site 267671004693 catalytic tetrad [active] 267671004694 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 267671004695 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 267671004696 putative Iron-sulfur protein interface [polypeptide binding]; other site 267671004697 proximal heme binding site [chemical binding]; other site 267671004698 distal heme binding site [chemical binding]; other site 267671004699 putative dimer interface [polypeptide binding]; other site 267671004700 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 267671004701 L-aspartate oxidase; Provisional; Region: PRK06175 267671004702 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 267671004703 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 267671004704 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 267671004705 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 267671004706 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 267671004707 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 267671004708 putative trimer interface [polypeptide binding]; other site 267671004709 putative CoA binding site [chemical binding]; other site 267671004710 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 267671004711 GTP-binding protein LepA; Provisional; Region: PRK05433 267671004712 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 267671004713 G1 box; other site 267671004714 putative GEF interaction site [polypeptide binding]; other site 267671004715 GTP/Mg2+ binding site [chemical binding]; other site 267671004716 Switch I region; other site 267671004717 G2 box; other site 267671004718 G3 box; other site 267671004719 Switch II region; other site 267671004720 G4 box; other site 267671004721 G5 box; other site 267671004722 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 267671004723 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 267671004724 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 267671004725 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 267671004726 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671004727 anti sigma factor interaction site; other site 267671004728 regulatory phosphorylation site [posttranslational modification]; other site 267671004729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 267671004730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671004731 salt bridge; other site 267671004732 non-specific DNA binding site [nucleotide binding]; other site 267671004733 sequence-specific DNA binding site [nucleotide binding]; other site 267671004734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671004735 non-specific DNA binding site [nucleotide binding]; other site 267671004736 salt bridge; other site 267671004737 sequence-specific DNA binding site [nucleotide binding]; other site 267671004738 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 267671004739 Clp amino terminal domain; Region: Clp_N; pfam02861 267671004740 Clp amino terminal domain; Region: Clp_N; pfam02861 267671004741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671004742 Walker A motif; other site 267671004743 ATP binding site [chemical binding]; other site 267671004744 Walker B motif; other site 267671004745 arginine finger; other site 267671004746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671004747 Walker A motif; other site 267671004748 ATP binding site [chemical binding]; other site 267671004749 Walker B motif; other site 267671004750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 267671004751 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 267671004752 Na2 binding site [ion binding]; other site 267671004753 substrate binding site 1 [chemical binding]; other site 267671004754 Na binding site 1 [ion binding]; other site 267671004755 substrate binding site 2 [chemical binding]; other site 267671004756 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 267671004757 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 267671004758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671004759 putative Mg++ binding site [ion binding]; other site 267671004760 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 267671004761 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671004762 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 267671004763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671004764 TPR motif; other site 267671004765 binding surface 267671004766 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 267671004767 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 267671004768 putative dimer interface [polypeptide binding]; other site 267671004769 putative anticodon binding site; other site 267671004770 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 267671004771 homodimer interface [polypeptide binding]; other site 267671004772 motif 1; other site 267671004773 motif 2; other site 267671004774 active site 267671004775 motif 3; other site 267671004776 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14177 267671004777 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 267671004778 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 267671004779 homodimer interface [polypeptide binding]; other site 267671004780 NADP binding site [chemical binding]; other site 267671004781 substrate binding site [chemical binding]; other site 267671004782 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 267671004783 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 267671004784 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 267671004785 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 267671004786 active site 267671004787 HIGH motif; other site 267671004788 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 267671004789 KMSKS motif; other site 267671004790 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 267671004791 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 267671004792 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 267671004793 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 267671004794 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671004795 PGAP1-like protein; Region: PGAP1; pfam07819 267671004796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671004797 PAS fold; Region: PAS_3; pfam08447 267671004798 putative active site [active] 267671004799 heme pocket [chemical binding]; other site 267671004800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671004801 PAS fold; Region: PAS_3; pfam08447 267671004802 putative active site [active] 267671004803 heme pocket [chemical binding]; other site 267671004804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671004805 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 267671004806 putative active site [active] 267671004807 heme pocket [chemical binding]; other site 267671004808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671004809 putative active site [active] 267671004810 heme pocket [chemical binding]; other site 267671004811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671004812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004813 ATP binding site [chemical binding]; other site 267671004814 Mg2+ binding site [ion binding]; other site 267671004815 G-X-G motif; other site 267671004816 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 267671004817 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 267671004818 tetramer interface [polypeptide binding]; other site 267671004819 heme binding pocket [chemical binding]; other site 267671004820 NADPH binding site [chemical binding]; other site 267671004821 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671004822 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671004823 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 267671004824 metal binding site 2 [ion binding]; metal-binding site 267671004825 putative DNA binding helix; other site 267671004826 metal binding site 1 [ion binding]; metal-binding site 267671004827 structural Zn2+ binding site [ion binding]; other site 267671004828 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 267671004829 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 267671004830 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 267671004831 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 267671004832 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 267671004833 dimer interface [polypeptide binding]; other site 267671004834 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671004835 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 267671004836 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 267671004837 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 267671004838 Family description; Region: VCBS; pfam13517 267671004839 Family description; Region: VCBS; pfam13517 267671004840 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 267671004841 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 267671004842 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 267671004843 RHS Repeat; Region: RHS_repeat; pfam05593 267671004844 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 267671004845 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 267671004846 kelch-like protein; Provisional; Region: PHA03098 267671004847 putative transposase OrfB; Reviewed; Region: PHA02517 267671004848 Integrase core domain; Region: rve; pfam00665 267671004849 Integrase core domain; Region: rve_3; pfam13683 267671004850 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004852 active site 267671004853 phosphorylation site [posttranslational modification] 267671004854 intermolecular recognition site; other site 267671004855 dimerization interface [polypeptide binding]; other site 267671004856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004857 dimer interface [polypeptide binding]; other site 267671004858 phosphorylation site [posttranslational modification] 267671004859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004860 ATP binding site [chemical binding]; other site 267671004861 Mg2+ binding site [ion binding]; other site 267671004862 G-X-G motif; other site 267671004863 Response regulator receiver domain; Region: Response_reg; pfam00072 267671004864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004865 active site 267671004866 phosphorylation site [posttranslational modification] 267671004867 intermolecular recognition site; other site 267671004868 dimerization interface [polypeptide binding]; other site 267671004869 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 267671004870 GAF domain; Region: GAF_3; pfam13492 267671004871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004872 dimer interface [polypeptide binding]; other site 267671004873 phosphorylation site [posttranslational modification] 267671004874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004875 ATP binding site [chemical binding]; other site 267671004876 Mg2+ binding site [ion binding]; other site 267671004877 G-X-G motif; other site 267671004878 Response regulator receiver domain; Region: Response_reg; pfam00072 267671004879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004880 active site 267671004881 phosphorylation site [posttranslational modification] 267671004882 intermolecular recognition site; other site 267671004883 dimerization interface [polypeptide binding]; other site 267671004884 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 267671004885 CheB methylesterase; Region: CheB_methylest; pfam01339 267671004886 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 267671004887 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 267671004888 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 267671004889 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267671004890 putative acyl-acceptor binding pocket; other site 267671004891 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 267671004892 Transcriptional regulators [Transcription]; Region: MarR; COG1846 267671004893 MarR family; Region: MarR_2; pfam12802 267671004894 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 267671004895 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 267671004896 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 267671004897 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671004898 anti sigma factor interaction site; other site 267671004899 regulatory phosphorylation site [posttranslational modification]; other site 267671004900 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 267671004901 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 267671004902 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 267671004903 tetramerization interface [polypeptide binding]; other site 267671004904 active site 267671004905 HDOD domain; Region: HDOD; pfam08668 267671004906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671004907 Zn2+ binding site [ion binding]; other site 267671004908 Mg2+ binding site [ion binding]; other site 267671004909 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 267671004910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671004911 Walker A/P-loop; other site 267671004912 ATP binding site [chemical binding]; other site 267671004913 Q-loop/lid; other site 267671004914 ABC transporter signature motif; other site 267671004915 Walker B; other site 267671004916 D-loop; other site 267671004917 H-loop/switch region; other site 267671004918 DNA topoisomerase I; Validated; Region: PRK05582 267671004919 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 267671004920 active site 267671004921 interdomain interaction site; other site 267671004922 putative metal-binding site [ion binding]; other site 267671004923 nucleotide binding site [chemical binding]; other site 267671004924 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 267671004925 domain I; other site 267671004926 DNA binding groove [nucleotide binding] 267671004927 phosphate binding site [ion binding]; other site 267671004928 domain II; other site 267671004929 domain III; other site 267671004930 nucleotide binding site [chemical binding]; other site 267671004931 catalytic site [active] 267671004932 domain IV; other site 267671004933 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 267671004934 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 267671004935 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 267671004936 dimer interface [polypeptide binding]; other site 267671004937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671004938 catalytic residue [active] 267671004939 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 267671004940 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 267671004941 trimer interface [polypeptide binding]; other site 267671004942 putative metal binding site [ion binding]; other site 267671004943 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 267671004944 PAS domain S-box; Region: sensory_box; TIGR00229 267671004945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671004946 putative active site [active] 267671004947 heme pocket [chemical binding]; other site 267671004948 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 267671004949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671004950 putative active site [active] 267671004951 heme pocket [chemical binding]; other site 267671004952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004953 dimer interface [polypeptide binding]; other site 267671004954 phosphorylation site [posttranslational modification] 267671004955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004956 ATP binding site [chemical binding]; other site 267671004957 Mg2+ binding site [ion binding]; other site 267671004958 G-X-G motif; other site 267671004959 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004961 active site 267671004962 phosphorylation site [posttranslational modification] 267671004963 intermolecular recognition site; other site 267671004964 dimerization interface [polypeptide binding]; other site 267671004965 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 267671004966 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 267671004967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 267671004968 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 267671004969 Phosphoglycerate kinase; Region: PGK; pfam00162 267671004970 substrate binding site [chemical binding]; other site 267671004971 hinge regions; other site 267671004972 ADP binding site [chemical binding]; other site 267671004973 catalytic site [active] 267671004974 triosephosphate isomerase; Provisional; Region: PRK14567 267671004975 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 267671004976 substrate binding site [chemical binding]; other site 267671004977 dimer interface [polypeptide binding]; other site 267671004978 catalytic triad [active] 267671004979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671004980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671004981 dimer interface [polypeptide binding]; other site 267671004982 phosphorylation site [posttranslational modification] 267671004983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671004984 ATP binding site [chemical binding]; other site 267671004985 Mg2+ binding site [ion binding]; other site 267671004986 G-X-G motif; other site 267671004987 Response regulator receiver domain; Region: Response_reg; pfam00072 267671004988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671004989 active site 267671004990 phosphorylation site [posttranslational modification] 267671004991 intermolecular recognition site; other site 267671004992 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 267671004993 Beta-propeller repeat; Region: SBBP; pfam06739 267671004994 Beta-propeller repeat; Region: SBBP; pfam06739 267671004995 Beta-propeller repeat; Region: SBBP; pfam06739 267671004996 Beta-propeller repeat; Region: SBBP; pfam06739 267671004997 Beta-propeller repeat; Region: SBBP; pfam06739 267671004998 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 267671004999 competence damage-inducible protein A; Provisional; Region: PRK00549 267671005000 putative MPT binding site; other site 267671005001 Competence-damaged protein; Region: CinA; pfam02464 267671005002 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 267671005003 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 267671005004 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 267671005005 active site 267671005006 HIGH motif; other site 267671005007 KMSK motif region; other site 267671005008 DALR anticodon binding domain; Region: DALR_1; smart00836 267671005009 anticodon binding site; other site 267671005010 tRNA binding surface [nucleotide binding]; other site 267671005011 Recombination protein O N terminal; Region: RecO_N; pfam11967 267671005012 DNA repair protein RecO; Region: reco; TIGR00613 267671005013 Recombination protein O C terminal; Region: RecO_C; pfam02565 267671005014 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 267671005015 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 267671005016 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 267671005017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671005018 Zn2+ binding site [ion binding]; other site 267671005019 Mg2+ binding site [ion binding]; other site 267671005020 PhoH-like protein; Region: PhoH; pfam02562 267671005021 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 267671005022 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 267671005023 dimer interface [polypeptide binding]; other site 267671005024 anticodon binding site; other site 267671005025 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 267671005026 homodimer interface [polypeptide binding]; other site 267671005027 motif 1; other site 267671005028 active site 267671005029 motif 2; other site 267671005030 GAD domain; Region: GAD; pfam02938 267671005031 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 267671005032 motif 3; other site 267671005033 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 267671005034 replicative DNA helicase; Region: DnaB; TIGR00665 267671005035 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 267671005036 Walker A motif; other site 267671005037 ATP binding site [chemical binding]; other site 267671005038 Walker B motif; other site 267671005039 DNA binding loops [nucleotide binding] 267671005040 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 267671005041 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 267671005042 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 267671005043 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 267671005044 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 267671005045 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 267671005046 dimer interface [polypeptide binding]; other site 267671005047 ssDNA binding site [nucleotide binding]; other site 267671005048 tetramer (dimer of dimers) interface [polypeptide binding]; other site 267671005049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 267671005050 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 267671005051 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 267671005052 putative active site [active] 267671005053 putative metal binding site [ion binding]; other site 267671005054 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005055 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005056 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005057 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005058 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 267671005059 HicB family; Region: HicB; pfam05534 267671005060 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 267671005061 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 267671005062 transmembrane helices; other site 267671005063 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 267671005064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671005065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671005066 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 267671005067 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 267671005068 Ligand binding site; other site 267671005069 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 267671005070 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 267671005071 Probable Catalytic site; other site 267671005072 metal-binding site 267671005073 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 267671005074 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 267671005075 substrate binding site; other site 267671005076 tetramer interface; other site 267671005077 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 267671005078 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 267671005079 NAD binding site [chemical binding]; other site 267671005080 substrate binding site [chemical binding]; other site 267671005081 homodimer interface [polypeptide binding]; other site 267671005082 active site 267671005083 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 267671005084 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 267671005085 NADP binding site [chemical binding]; other site 267671005086 active site 267671005087 putative substrate binding site [chemical binding]; other site 267671005088 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 267671005089 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 267671005090 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 267671005091 Probable Catalytic site; other site 267671005092 metal-binding site 267671005093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671005094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671005095 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 267671005096 active site 267671005097 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 267671005098 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 267671005099 metal-binding site 267671005100 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 267671005101 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671005102 inhibitor-cofactor binding pocket; inhibition site 267671005103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005104 catalytic residue [active] 267671005105 WxcM-like, C-terminal; Region: FdtA; pfam05523 267671005106 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 267671005107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671005108 active site 267671005109 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 267671005110 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 267671005111 Protein of unknown function (DUF1229); Region: DUF1229; pfam06797 267671005112 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 267671005113 Bacterial sugar transferase; Region: Bac_transf; pfam02397 267671005114 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671005115 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 267671005116 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 267671005117 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 267671005118 active site 267671005119 homodimer interface [polypeptide binding]; other site 267671005120 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 267671005121 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 267671005122 putative NAD(P) binding site [chemical binding]; other site 267671005123 active site 267671005124 putative substrate binding site [chemical binding]; other site 267671005125 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 267671005126 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 267671005127 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 267671005128 NAD(P) binding site [chemical binding]; other site 267671005129 homodimer interface [polypeptide binding]; other site 267671005130 substrate binding site [chemical binding]; other site 267671005131 active site 267671005132 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 267671005133 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671005134 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 267671005135 Protein of unknown function (DUF1420); Region: DUF1420; pfam07220 267671005136 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671005137 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267671005138 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671005139 catalytic residue [active] 267671005140 FemAB family; Region: FemAB; pfam02388 267671005141 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 267671005142 putative active site [active] 267671005143 putative metal binding site [ion binding]; other site 267671005144 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 267671005145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671005146 active site 267671005147 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 267671005148 extended (e) SDRs; Region: SDR_e; cd08946 267671005149 NAD(P) binding site [chemical binding]; other site 267671005150 active site 267671005151 substrate binding site [chemical binding]; other site 267671005152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671005153 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 267671005154 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 267671005155 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 267671005156 NAD binding site [chemical binding]; other site 267671005157 homotetramer interface [polypeptide binding]; other site 267671005158 homodimer interface [polypeptide binding]; other site 267671005159 substrate binding site [chemical binding]; other site 267671005160 active site 267671005161 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 267671005162 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 267671005163 substrate binding site; other site 267671005164 surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326 267671005165 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 267671005166 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 267671005167 putative ligand binding site [chemical binding]; other site 267671005168 putative NAD binding site [chemical binding]; other site 267671005169 catalytic site [active] 267671005170 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 267671005171 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 267671005172 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671005173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671005174 S-adenosylmethionine binding site [chemical binding]; other site 267671005175 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 267671005176 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 267671005177 active site 267671005178 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267671005179 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 267671005180 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 267671005181 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 267671005182 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 267671005183 Ligand binding site; other site 267671005184 oligomer interface; other site 267671005185 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 267671005186 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 267671005187 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 267671005188 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 267671005189 putative active site [active] 267671005190 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 267671005191 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 267671005192 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 267671005193 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671005194 Methyltransferase domain; Region: Methyltransf_12; pfam08242 267671005195 Radical SAM superfamily; Region: Radical_SAM; pfam04055 267671005196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671005197 FeS/SAM binding site; other site 267671005198 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 267671005199 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH3; cd08184 267671005200 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 267671005201 putative active site [active] 267671005202 metal binding site [ion binding]; metal-binding site 267671005203 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 267671005204 ligand binding site; other site 267671005205 tetramer interface; other site 267671005206 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671005207 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671005208 inhibitor-cofactor binding pocket; inhibition site 267671005209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005210 catalytic residue [active] 267671005211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 267671005212 FOG: CBS domain [General function prediction only]; Region: COG0517 267671005213 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 267671005214 NeuB family; Region: NeuB; pfam03102 267671005215 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 267671005216 NeuB binding interface [polypeptide binding]; other site 267671005217 putative substrate binding site [chemical binding]; other site 267671005218 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 267671005219 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 267671005220 Metal-binding active site; metal-binding site 267671005221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 267671005222 FOG: CBS domain [General function prediction only]; Region: COG0517 267671005223 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 267671005224 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 267671005225 Substrate binding site; other site 267671005226 metal-binding site 267671005227 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 267671005228 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 267671005229 active site 267671005230 homodimer interface [polypeptide binding]; other site 267671005231 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 267671005232 NeuB family; Region: NeuB; pfam03102 267671005233 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 267671005234 NeuB binding interface [polypeptide binding]; other site 267671005235 putative substrate binding site [chemical binding]; other site 267671005236 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 267671005237 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 267671005238 putative trimer interface [polypeptide binding]; other site 267671005239 putative CoA binding site [chemical binding]; other site 267671005240 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 267671005241 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671005242 inhibitor-cofactor binding pocket; inhibition site 267671005243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005244 catalytic residue [active] 267671005245 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 267671005246 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 267671005247 NAD binding site [chemical binding]; other site 267671005248 substrate binding site [chemical binding]; other site 267671005249 active site 267671005250 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 267671005251 ligand binding site; other site 267671005252 tetramer interface; other site 267671005253 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 267671005254 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 267671005255 Ligand binding site; other site 267671005256 Putative Catalytic site; other site 267671005257 DXD motif; other site 267671005258 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671005259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671005260 S-adenosylmethionine binding site [chemical binding]; other site 267671005261 WxcM-like, C-terminal; Region: FdtA; pfam05523 267671005262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 267671005263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671005264 Walker A/P-loop; other site 267671005265 ATP binding site [chemical binding]; other site 267671005266 Q-loop/lid; other site 267671005267 ABC transporter signature motif; other site 267671005268 Walker B; other site 267671005269 D-loop; other site 267671005270 H-loop/switch region; other site 267671005271 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 267671005272 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 267671005273 putative trimer interface [polypeptide binding]; other site 267671005274 putative CoA binding site [chemical binding]; other site 267671005275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671005276 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 267671005277 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 267671005278 active site 267671005279 substrate binding site [chemical binding]; other site 267671005280 cosubstrate binding site; other site 267671005281 catalytic site [active] 267671005282 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 267671005283 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671005284 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671005285 inhibitor-cofactor binding pocket; inhibition site 267671005286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005287 catalytic residue [active] 267671005288 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 267671005289 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671005290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671005291 S-adenosylmethionine binding site [chemical binding]; other site 267671005292 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 267671005293 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 267671005294 Methyltransferase domain; Region: Methyltransf_31; pfam13847 267671005295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671005296 S-adenosylmethionine binding site [chemical binding]; other site 267671005297 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 267671005298 active site 267671005299 8-oxo-dGMP binding site [chemical binding]; other site 267671005300 nudix motif; other site 267671005301 metal binding site [ion binding]; metal-binding site 267671005302 sporadic carbohydrate cluster protein, LIC12192 family; Region: SpoChoClust_1; TIGR04323 267671005303 sporadic carbohydrate cluster 2OG-Fe(II) oxygenase; Region: SpoChoClust_2; TIGR04324 267671005304 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 267671005305 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 267671005306 PYR/PP interface [polypeptide binding]; other site 267671005307 dimer interface [polypeptide binding]; other site 267671005308 TPP binding site [chemical binding]; other site 267671005309 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 267671005310 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 267671005311 transketolase; Reviewed; Region: PRK05899 267671005312 TPP-binding site [chemical binding]; other site 267671005313 dimer interface [polypeptide binding]; other site 267671005314 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 267671005315 Phosphotransferase enzyme family; Region: APH; pfam01636 267671005316 active site 267671005317 ATP binding site [chemical binding]; other site 267671005318 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671005319 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671005320 inhibitor-cofactor binding pocket; inhibition site 267671005321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005322 catalytic residue [active] 267671005323 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671005324 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671005325 inhibitor-cofactor binding pocket; inhibition site 267671005326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005327 catalytic residue [active] 267671005328 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 267671005329 extended (e) SDRs; Region: SDR_e; cd08946 267671005330 NAD(P) binding site [chemical binding]; other site 267671005331 active site 267671005332 substrate binding site [chemical binding]; other site 267671005333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671005334 cytidylyltransferase; Region: cytidylyltransferase; cd02170 267671005335 active site 267671005336 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 267671005337 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267671005338 putative ribose interaction site [chemical binding]; other site 267671005339 putative ADP binding site [chemical binding]; other site 267671005340 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 267671005341 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 267671005342 active site 267671005343 Substrate binding site; other site 267671005344 Mg++ binding site; other site 267671005345 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 267671005346 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 267671005347 NAD binding site [chemical binding]; other site 267671005348 substrate binding site [chemical binding]; other site 267671005349 homodimer interface [polypeptide binding]; other site 267671005350 active site 267671005351 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 267671005352 dimer interface [polypeptide binding]; other site 267671005353 active site 267671005354 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 267671005355 hydroxyglutarate oxidase; Provisional; Region: PRK11728 267671005356 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 267671005357 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 267671005358 NADP binding site [chemical binding]; other site 267671005359 active site 267671005360 putative substrate binding site [chemical binding]; other site 267671005361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671005362 putative DNA binding site [nucleotide binding]; other site 267671005363 putative Zn2+ binding site [ion binding]; other site 267671005364 Beta-propeller repeat; Region: SBBP; pfam06739 267671005365 Beta-propeller repeat; Region: SBBP; pfam06739 267671005366 Beta-propeller repeat; Region: SBBP; pfam06739 267671005367 Beta-propeller repeat; Region: SBBP; pfam06739 267671005368 Beta-propeller repeat; Region: SBBP; pfam06739 267671005369 Beta-propeller repeat; Region: SBBP; pfam06739 267671005370 Beta-propeller repeat; Region: SBBP; pfam06739 267671005371 Beta-propeller repeat; Region: SBBP; pfam06739 267671005372 Beta-propeller repeat; Region: SBBP; pfam06739 267671005373 Beta-propeller repeat; Region: SBBP; pfam06739 267671005374 Beta-propeller repeat; Region: SBBP; pfam06739 267671005375 Beta-propeller repeat; Region: SBBP; pfam06739 267671005376 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 267671005377 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 267671005378 putative dimer interface [polypeptide binding]; other site 267671005379 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 267671005380 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 267671005381 putative dimer interface [polypeptide binding]; other site 267671005382 Protein of unknown function, DUF486; Region: DUF486; cl01236 267671005383 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 267671005384 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 267671005385 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 267671005386 Cu(I) binding site [ion binding]; other site 267671005387 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 267671005388 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 267671005389 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 267671005390 Right handed beta helix region; Region: Beta_helix; pfam13229 267671005391 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 267671005392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267671005393 Histidine kinase; Region: HisKA_2; pfam07568 267671005394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671005395 ATP binding site [chemical binding]; other site 267671005396 Mg2+ binding site [ion binding]; other site 267671005397 G-X-G motif; other site 267671005398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 267671005399 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 267671005400 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 267671005401 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 267671005402 DNA methylase; Region: N6_N4_Mtase; pfam01555 267671005403 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 267671005404 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 267671005405 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 267671005406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 267671005407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 267671005408 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 267671005409 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 267671005410 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 267671005411 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 267671005412 Thymidylate synthase complementing protein; Region: Thy1; cl03630 267671005413 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 267671005414 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 267671005415 putative active site; other site 267671005416 catalytic residue [active] 267671005417 Leucine rich repeat; Region: LRR_8; pfam13855 267671005418 Response regulator receiver domain; Region: Response_reg; pfam00072 267671005419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671005420 active site 267671005421 phosphorylation site [posttranslational modification] 267671005422 intermolecular recognition site; other site 267671005423 dimerization interface [polypeptide binding]; other site 267671005424 PAS fold; Region: PAS; pfam00989 267671005425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671005426 putative active site [active] 267671005427 heme pocket [chemical binding]; other site 267671005428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671005429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671005430 dimer interface [polypeptide binding]; other site 267671005431 phosphorylation site [posttranslational modification] 267671005432 FOG: CBS domain [General function prediction only]; Region: COG0517 267671005433 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 267671005434 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 267671005435 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 267671005436 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 267671005437 Substrate binding site; other site 267671005438 Cupin domain; Region: Cupin_2; cl17218 267671005439 bacterial Hfq-like; Region: Hfq; cd01716 267671005440 hexamer interface [polypeptide binding]; other site 267671005441 Sm1 motif; other site 267671005442 RNA binding site [nucleotide binding]; other site 267671005443 Sm2 motif; other site 267671005444 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 267671005445 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 267671005446 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 267671005447 TIGR02300 family protein; Region: FYDLN_acid 267671005448 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 267671005449 active site 267671005450 hydrophilic channel; other site 267671005451 dimerization interface [polypeptide binding]; other site 267671005452 catalytic residues [active] 267671005453 active site lid [active] 267671005454 Xyloglucan fucosyltransferase; Region: XG_FTase; pfam03254 267671005455 C-terminal peptidase (prc); Region: prc; TIGR00225 267671005456 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 267671005457 protein binding site [polypeptide binding]; other site 267671005458 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 267671005459 Catalytic dyad [active] 267671005460 L-aspartate oxidase; Provisional; Region: PRK09077 267671005461 L-aspartate oxidase; Provisional; Region: PRK06175 267671005462 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 267671005463 Surface antigen; Region: Bac_surface_Ag; pfam01103 267671005464 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671005465 Surface antigen; Region: Bac_surface_Ag; pfam01103 267671005466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671005467 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671005468 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 267671005469 Surface antigen; Region: Bac_surface_Ag; pfam01103 267671005470 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671005471 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671005472 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671005473 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671005474 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671005475 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671005476 Family description; Region: VCBS; pfam13517 267671005477 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 267671005478 Family description; Region: VCBS; pfam13517 267671005479 FG-GAP repeat; Region: FG-GAP; pfam01839 267671005480 FG-GAP repeat; Region: FG-GAP; pfam01839 267671005481 Family description; Region: VCBS; pfam13517 267671005482 Family description; Region: VCBS; pfam13517 267671005483 FG-GAP repeat; Region: FG-GAP; pfam01839 267671005484 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 267671005485 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671005486 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671005487 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 267671005488 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 267671005489 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267671005490 RNA binding surface [nucleotide binding]; other site 267671005491 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 267671005492 active site 267671005493 PilZ domain; Region: PilZ; pfam07238 267671005494 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 267671005495 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 267671005496 active site 267671005497 substrate binding site [chemical binding]; other site 267671005498 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 267671005499 FMN binding site [chemical binding]; other site 267671005500 putative catalytic residues [active] 267671005501 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 267671005502 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 267671005503 Ligand Binding Site [chemical binding]; other site 267671005504 Aspartyl protease; Region: Asp_protease_2; pfam13650 267671005505 inhibitor binding site; inhibition site 267671005506 catalytic motif [active] 267671005507 Catalytic residue [active] 267671005508 Active site flap [active] 267671005509 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671005510 GAF domain; Region: GAF_3; pfam13492 267671005511 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671005512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671005513 metal binding site [ion binding]; metal-binding site 267671005514 active site 267671005515 I-site; other site 267671005516 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 267671005517 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 267671005518 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 267671005519 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 267671005520 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267671005521 catalytic residue [active] 267671005522 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 267671005523 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 267671005524 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 267671005525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267671005526 motif II; other site 267671005527 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 267671005528 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 267671005529 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671005530 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 267671005531 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 267671005532 TPR repeat; Region: TPR_11; pfam13414 267671005533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671005534 binding surface 267671005535 TPR motif; other site 267671005536 TRL-like protein family; Region: TRL; pfam13146 267671005537 TRL-like protein family; Region: TRL; pfam13146 267671005538 TRL-like protein family; Region: TRL; pfam13146 267671005539 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 267671005540 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 267671005541 Ca binding site [ion binding]; other site 267671005542 active site 267671005543 catalytic site [active] 267671005544 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 267671005545 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 267671005546 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 267671005547 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267671005548 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 267671005549 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 267671005550 ATP-grasp domain; Region: ATP-grasp; pfam02222 267671005551 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 267671005552 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 267671005553 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 267671005554 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 267671005555 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 267671005556 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 267671005557 Walker A/P-loop; other site 267671005558 ATP binding site [chemical binding]; other site 267671005559 Q-loop/lid; other site 267671005560 ABC transporter signature motif; other site 267671005561 Walker B; other site 267671005562 D-loop; other site 267671005563 H-loop/switch region; other site 267671005564 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 267671005565 putative carbohydrate binding site [chemical binding]; other site 267671005566 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 267671005567 hypothetical protein; Reviewed; Region: PRK00024 267671005568 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 267671005569 MPN+ (JAMM) motif; other site 267671005570 Zinc-binding site [ion binding]; other site 267671005571 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 267671005572 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 267671005573 UGMP family protein; Validated; Region: PRK09604 267671005574 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 267671005575 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 267671005576 C-terminal peptidase (prc); Region: prc; TIGR00225 267671005577 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 267671005578 protein binding site [polypeptide binding]; other site 267671005579 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 267671005580 Catalytic dyad [active] 267671005581 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 267671005582 LexA repressor; Validated; Region: PRK00215 267671005583 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 267671005584 Catalytic site [active] 267671005585 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 267671005586 HlyD family secretion protein; Region: HlyD_3; pfam13437 267671005587 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 267671005588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671005589 binding surface 267671005590 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671005591 TPR motif; other site 267671005592 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267671005593 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 267671005594 Walker A/P-loop; other site 267671005595 ATP binding site [chemical binding]; other site 267671005596 Q-loop/lid; other site 267671005597 ABC transporter signature motif; other site 267671005598 Walker B; other site 267671005599 D-loop; other site 267671005600 H-loop/switch region; other site 267671005601 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 267671005602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 267671005603 nucleotide binding site [chemical binding]; other site 267671005604 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 267671005605 nucleotide binding site/active site [active] 267671005606 HIT family signature motif; other site 267671005607 catalytic residue [active] 267671005608 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 267671005609 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671005610 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671005611 Response regulator receiver domain; Region: Response_reg; pfam00072 267671005612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671005613 active site 267671005614 phosphorylation site [posttranslational modification] 267671005615 intermolecular recognition site; other site 267671005616 dimerization interface [polypeptide binding]; other site 267671005617 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 267671005618 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 267671005619 active site 267671005620 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 267671005621 Protein phosphatase 2C; Region: PP2C; pfam00481 267671005622 active site 267671005623 short chain dehydrogenase; Provisional; Region: PRK06172 267671005624 classical (c) SDRs; Region: SDR_c; cd05233 267671005625 NAD(P) binding site [chemical binding]; other site 267671005626 active site 267671005627 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671005628 active site 267671005629 Coenzyme A transferase; Region: CoA_trans; pfam01144 267671005630 Coenzyme A transferase; Region: CoA_trans; cl17247 267671005631 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 267671005632 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 267671005633 dimer interface [polypeptide binding]; other site 267671005634 active site 267671005635 CoA binding pocket [chemical binding]; other site 267671005636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 267671005637 Catalytic domain of Protein Kinases; Region: PKc; cd00180 267671005638 active site 267671005639 ATP binding site [chemical binding]; other site 267671005640 substrate binding site [chemical binding]; other site 267671005641 activation loop (A-loop); other site 267671005642 AAA ATPase domain; Region: AAA_16; pfam13191 267671005643 Predicted ATPase [General function prediction only]; Region: COG3899 267671005644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671005645 binding surface 267671005646 TPR motif; other site 267671005647 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671005648 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671005649 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671005650 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 267671005651 GAF domain; Region: GAF_3; pfam13492 267671005652 GAF domain; Region: GAF_2; pfam13185 267671005653 Heme NO binding associated; Region: HNOBA; pfam07701 267671005654 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 267671005655 cyclase homology domain; Region: CHD; cd07302 267671005656 nucleotidyl binding site; other site 267671005657 metal binding site [ion binding]; metal-binding site 267671005658 dimer interface [polypeptide binding]; other site 267671005659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671005660 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 267671005661 dimer interface [polypeptide binding]; other site 267671005662 substrate binding site [chemical binding]; other site 267671005663 metal binding site [ion binding]; metal-binding site 267671005664 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 267671005665 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 267671005666 tetramer interface [polypeptide binding]; other site 267671005667 active site 267671005668 Mg2+/Mn2+ binding site [ion binding]; other site 267671005669 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 267671005670 putative catalytic site [active] 267671005671 putative metal binding site [ion binding]; other site 267671005672 putative phosphate binding site [ion binding]; other site 267671005673 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 267671005674 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 267671005675 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 267671005676 dimer interface [polypeptide binding]; other site 267671005677 active site 267671005678 glycine-pyridoxal phosphate binding site [chemical binding]; other site 267671005679 folate binding site [chemical binding]; other site 267671005680 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 267671005681 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 267671005682 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671005683 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671005684 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 267671005685 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 267671005686 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 267671005687 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 267671005688 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 267671005689 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 267671005690 substrate binding site [chemical binding]; other site 267671005691 ATP binding site [chemical binding]; other site 267671005692 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 267671005693 Protease prsW family; Region: PrsW-protease; pfam13367 267671005694 Gram-negative bacterial tonB protein; Region: TonB; cl10048 267671005695 glycyl-tRNA synthetase; Provisional; Region: PRK04173 267671005696 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 267671005697 motif 1; other site 267671005698 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 267671005699 active site 267671005700 motif 2; other site 267671005701 motif 3; other site 267671005702 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 267671005703 anticodon binding site; other site 267671005704 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 267671005705 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 267671005706 conserved cys residue [active] 267671005707 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 267671005708 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 267671005709 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 267671005710 G1 box; other site 267671005711 putative GEF interaction site [polypeptide binding]; other site 267671005712 GTP/Mg2+ binding site [chemical binding]; other site 267671005713 Switch I region; other site 267671005714 G2 box; other site 267671005715 G3 box; other site 267671005716 Switch II region; other site 267671005717 G4 box; other site 267671005718 G5 box; other site 267671005719 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 267671005720 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 267671005721 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 267671005722 putative active site [active] 267671005723 catalytic site [active] 267671005724 putative metal binding site [ion binding]; other site 267671005725 Pirin-related protein [General function prediction only]; Region: COG1741 267671005726 Pirin; Region: Pirin; pfam02678 267671005727 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 267671005728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267671005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671005730 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 267671005731 endonuclease III; Region: ENDO3c; smart00478 267671005732 minor groove reading motif; other site 267671005733 helix-hairpin-helix signature motif; other site 267671005734 substrate binding pocket [chemical binding]; other site 267671005735 active site 267671005736 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 267671005737 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 267671005738 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671005739 Oligomerisation domain; Region: Oligomerisation; pfam02410 267671005740 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 267671005741 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 267671005742 MepB protein; Region: MepB; pfam08877 267671005743 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 267671005744 hydrophobic ligand binding site; other site 267671005745 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 267671005746 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005747 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005748 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 267671005749 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 267671005750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 267671005751 N-terminal plug; other site 267671005752 ligand-binding site [chemical binding]; other site 267671005753 Leucine rich repeat; Region: LRR_8; pfam13855 267671005754 Leucine rich repeat; Region: LRR_8; pfam13855 267671005755 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 267671005756 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 267671005757 putative active site [active] 267671005758 putative metal binding site [ion binding]; other site 267671005759 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671005760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671005761 S-adenosylmethionine binding site [chemical binding]; other site 267671005762 CHASE3 domain; Region: CHASE3; pfam05227 267671005763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671005764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671005765 dimer interface [polypeptide binding]; other site 267671005766 phosphorylation site [posttranslational modification] 267671005767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671005768 ATP binding site [chemical binding]; other site 267671005769 Mg2+ binding site [ion binding]; other site 267671005770 G-X-G motif; other site 267671005771 Response regulator receiver domain; Region: Response_reg; pfam00072 267671005772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671005773 active site 267671005774 phosphorylation site [posttranslational modification] 267671005775 intermolecular recognition site; other site 267671005776 dimerization interface [polypeptide binding]; other site 267671005777 PGAP1-like protein; Region: PGAP1; pfam07819 267671005778 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 267671005779 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 267671005780 putative acyl-acceptor binding pocket; other site 267671005781 bile acid transporter; Region: bass; TIGR00841 267671005782 Sodium Bile acid symporter family; Region: SBF; pfam01758 267671005783 EamA-like transporter family; Region: EamA; pfam00892 267671005784 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 267671005785 EamA-like transporter family; Region: EamA; pfam00892 267671005786 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 267671005787 Domain of unknown function DUF20; Region: UPF0118; pfam01594 267671005788 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671005789 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671005790 ligand binding site [chemical binding]; other site 267671005791 flexible hinge region; other site 267671005792 lipoprotein signal peptidase; Provisional; Region: PRK14783 267671005793 ABC1 family; Region: ABC1; cl17513 267671005794 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 267671005795 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 267671005796 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 267671005797 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 267671005798 amidase; Provisional; Region: PRK06529 267671005799 Amidase; Region: Amidase; pfam01425 267671005800 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005801 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005802 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005803 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005804 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 267671005805 Predicted amidohydrolase [General function prediction only]; Region: COG0388 267671005806 active site 267671005807 catalytic triad [active] 267671005808 dimer interface [polypeptide binding]; other site 267671005809 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671005810 anti sigma factor interaction site; other site 267671005811 regulatory phosphorylation site [posttranslational modification]; other site 267671005812 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 267671005813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 267671005814 active site 267671005815 HIGH motif; other site 267671005816 nucleotide binding site [chemical binding]; other site 267671005817 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 267671005818 active site 267671005819 KMSKS motif; other site 267671005820 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 267671005821 tRNA binding surface [nucleotide binding]; other site 267671005822 anticodon binding site; other site 267671005823 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 267671005824 Leucine rich repeat; Region: LRR_8; pfam13855 267671005825 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 267671005826 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 267671005827 dimerization interface [polypeptide binding]; other site 267671005828 ATP binding site [chemical binding]; other site 267671005829 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 267671005830 dimerization interface [polypeptide binding]; other site 267671005831 ATP binding site [chemical binding]; other site 267671005832 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 267671005833 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 267671005834 glutamine synthetase, type I; Region: GlnA; TIGR00653 267671005835 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 267671005836 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 267671005837 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671005838 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 267671005839 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 267671005840 Walker A/P-loop; other site 267671005841 ATP binding site [chemical binding]; other site 267671005842 Q-loop/lid; other site 267671005843 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 267671005844 ABC transporter signature motif; other site 267671005845 Walker B; other site 267671005846 D-loop; other site 267671005847 H-loop/switch region; other site 267671005848 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 267671005849 membrane protein; Provisional; Region: PRK14409 267671005850 GTP-binding protein Der; Reviewed; Region: PRK00093 267671005851 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 267671005852 G1 box; other site 267671005853 GTP/Mg2+ binding site [chemical binding]; other site 267671005854 Switch I region; other site 267671005855 G2 box; other site 267671005856 Switch II region; other site 267671005857 G3 box; other site 267671005858 G4 box; other site 267671005859 G5 box; other site 267671005860 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 267671005861 G1 box; other site 267671005862 GTP/Mg2+ binding site [chemical binding]; other site 267671005863 Switch I region; other site 267671005864 G2 box; other site 267671005865 G3 box; other site 267671005866 Switch II region; other site 267671005867 G4 box; other site 267671005868 G5 box; other site 267671005869 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 267671005870 SmpB-tmRNA interface; other site 267671005871 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005872 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005873 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671005874 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005875 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671005876 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671005877 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 267671005878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 267671005879 aspartate aminotransferase; Provisional; Region: PRK05764 267671005880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671005881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671005882 homodimer interface [polypeptide binding]; other site 267671005883 catalytic residue [active] 267671005884 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 267671005885 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 267671005886 Uncharacterized conserved protein [Function unknown]; Region: COG4715 267671005887 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 267671005888 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 267671005889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 267671005890 Walker A/P-loop; other site 267671005891 ATP binding site [chemical binding]; other site 267671005892 Q-loop/lid; other site 267671005893 ABC transporter signature motif; other site 267671005894 Walker B; other site 267671005895 D-loop; other site 267671005896 H-loop/switch region; other site 267671005897 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 267671005898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 267671005899 FtsX-like permease family; Region: FtsX; pfam02687 267671005900 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 267671005901 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 267671005902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671005903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671005904 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 267671005905 Sulfatase; Region: Sulfatase; pfam00884 267671005906 Sulfatase; Region: Sulfatase; pfam00884 267671005907 putative phosphate acyltransferase; Provisional; Region: PRK05331 267671005908 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 267671005909 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 267671005910 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 267671005911 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671005912 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 267671005913 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 267671005914 RNA binding site [nucleotide binding]; other site 267671005915 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 267671005916 RNA binding site [nucleotide binding]; other site 267671005917 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671005918 RNA binding site [nucleotide binding]; other site 267671005919 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671005920 RNA binding site [nucleotide binding]; other site 267671005921 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671005922 RNA binding site [nucleotide binding]; other site 267671005923 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 267671005924 RNA binding site [nucleotide binding]; other site 267671005925 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 267671005926 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 267671005927 hinge; other site 267671005928 active site 267671005929 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 267671005930 prephenate dehydrogenase; Validated; Region: PRK08507 267671005931 Chorismate mutase type II; Region: CM_2; pfam01817 267671005932 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 267671005933 Prephenate dehydratase; Region: PDT; pfam00800 267671005934 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 267671005935 putative L-Phe binding site [chemical binding]; other site 267671005936 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 267671005937 ScpA/B protein; Region: ScpA_ScpB; cl00598 267671005938 Response regulator receiver domain; Region: Response_reg; pfam00072 267671005939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671005940 active site 267671005941 phosphorylation site [posttranslational modification] 267671005942 intermolecular recognition site; other site 267671005943 dimerization interface [polypeptide binding]; other site 267671005944 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 267671005945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671005946 active site 267671005947 phosphorylation site [posttranslational modification] 267671005948 intermolecular recognition site; other site 267671005949 dimerization interface [polypeptide binding]; other site 267671005950 CheB methylesterase; Region: CheB_methylest; pfam01339 267671005951 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 267671005952 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 267671005953 Cell division protein ZapA; Region: ZapA; pfam05164 267671005954 Protein of unknown function (DUF904); Region: DUF904; cl11531 267671005955 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 267671005956 23S rRNA binding site [nucleotide binding]; other site 267671005957 L21 binding site [polypeptide binding]; other site 267671005958 L13 binding site [polypeptide binding]; other site 267671005959 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 267671005960 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 267671005961 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 267671005962 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 267671005963 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 267671005964 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 267671005965 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 267671005966 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 267671005967 active site 267671005968 dimer interface [polypeptide binding]; other site 267671005969 motif 1; other site 267671005970 motif 2; other site 267671005971 motif 3; other site 267671005972 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 267671005973 anticodon binding site; other site 267671005974 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 267671005975 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 267671005976 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 267671005977 catalytic site [active] 267671005978 subunit interface [polypeptide binding]; other site 267671005979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671005980 TPR motif; other site 267671005981 binding surface 267671005982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671005983 binding surface 267671005984 TPR motif; other site 267671005985 HSP90 family protein; Provisional; Region: PRK14083 267671005986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671005987 ATP binding site [chemical binding]; other site 267671005988 Mg2+ binding site [ion binding]; other site 267671005989 G-X-G motif; other site 267671005990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 267671005991 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 267671005992 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 267671005993 TPP-binding site [chemical binding]; other site 267671005994 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 267671005995 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 267671005996 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 267671005997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 267671005998 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 267671005999 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 267671006000 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 267671006001 E3 interaction surface; other site 267671006002 lipoyl attachment site [posttranslational modification]; other site 267671006003 e3 binding domain; Region: E3_binding; pfam02817 267671006004 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 267671006005 Transglycosylase; Region: Transgly; pfam00912 267671006006 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 267671006007 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 267671006008 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 267671006009 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671006010 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671006011 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 267671006012 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 267671006013 HAMP domain; Region: HAMP; pfam00672 267671006014 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 267671006015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671006016 dimer interface [polypeptide binding]; other site 267671006017 putative CheW interface [polypeptide binding]; other site 267671006018 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 267671006019 Ligand Binding Site [chemical binding]; other site 267671006020 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 267671006021 putative catalytic residues [active] 267671006022 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 267671006023 Peptidase family C69; Region: Peptidase_C69; cl17793 267671006024 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671006025 active site 267671006026 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 267671006027 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671006028 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671006029 DNA binding residues [nucleotide binding] 267671006030 PilZ domain; Region: PilZ; pfam07238 267671006031 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671006032 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 267671006033 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 267671006034 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 267671006035 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671006036 substrate binding site [chemical binding]; other site 267671006037 oxyanion hole (OAH) forming residues; other site 267671006038 trimer interface [polypeptide binding]; other site 267671006039 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671006040 Cache domain; Region: Cache_1; pfam02743 267671006041 HAMP domain; Region: HAMP; pfam00672 267671006042 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671006043 dimer interface [polypeptide binding]; other site 267671006044 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 267671006045 putative CheW interface [polypeptide binding]; other site 267671006046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006047 binding surface 267671006048 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671006049 TPR motif; other site 267671006050 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 267671006051 30S subunit binding site; other site 267671006052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671006053 Response regulator receiver domain; Region: Response_reg; pfam00072 267671006054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671006055 active site 267671006056 phosphorylation site [posttranslational modification] 267671006057 intermolecular recognition site; other site 267671006058 dimerization interface [polypeptide binding]; other site 267671006059 Response regulator receiver domain; Region: Response_reg; pfam00072 267671006060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671006061 active site 267671006062 phosphorylation site [posttranslational modification] 267671006063 intermolecular recognition site; other site 267671006064 dimerization interface [polypeptide binding]; other site 267671006065 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671006066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671006067 metal binding site [ion binding]; metal-binding site 267671006068 active site 267671006069 I-site; other site 267671006070 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671006071 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 267671006072 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 267671006073 catalytic loop [active] 267671006074 iron binding site [ion binding]; other site 267671006075 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671006076 cyclase homology domain; Region: CHD; cd07302 267671006077 nucleotidyl binding site; other site 267671006078 metal binding site [ion binding]; metal-binding site 267671006079 dimer interface [polypeptide binding]; other site 267671006080 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cd00314 267671006081 heme binding site [chemical binding]; other site 267671006082 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 267671006083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671006084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671006085 homodimer interface [polypeptide binding]; other site 267671006086 catalytic residue [active] 267671006087 recombination factor protein RarA; Reviewed; Region: PRK13342 267671006088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671006089 Walker A motif; other site 267671006090 ATP binding site [chemical binding]; other site 267671006091 Walker B motif; other site 267671006092 arginine finger; other site 267671006093 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 267671006094 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 267671006095 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 267671006096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671006097 ATP binding site [chemical binding]; other site 267671006098 Mg2+ binding site [ion binding]; other site 267671006099 G-X-G motif; other site 267671006100 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 267671006101 ATP binding site [chemical binding]; other site 267671006102 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 267671006103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 267671006104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 267671006105 substrate binding pocket [chemical binding]; other site 267671006106 membrane-bound complex binding site; other site 267671006107 hinge residues; other site 267671006108 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 267671006109 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 267671006110 acyl-activating enzyme (AAE) consensus motif; other site 267671006111 putative AMP binding site [chemical binding]; other site 267671006112 putative active site [active] 267671006113 putative CoA binding site [chemical binding]; other site 267671006114 Peptidase family M48; Region: Peptidase_M48; cl12018 267671006115 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 267671006116 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 267671006117 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 267671006118 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 267671006119 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267671006120 active site 267671006121 ATP binding site [chemical binding]; other site 267671006122 substrate binding site [chemical binding]; other site 267671006123 activation loop (A-loop); other site 267671006124 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 267671006125 AAA ATPase domain; Region: AAA_16; pfam13191 267671006126 Predicted ATPase [General function prediction only]; Region: COG3899 267671006127 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671006128 GAF domain; Region: GAF; pfam01590 267671006129 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671006130 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671006131 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 267671006132 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 267671006133 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671006134 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671006135 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 267671006136 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 267671006137 Walker A/P-loop; other site 267671006138 ATP binding site [chemical binding]; other site 267671006139 Q-loop/lid; other site 267671006140 ABC transporter signature motif; other site 267671006141 Walker B; other site 267671006142 D-loop; other site 267671006143 H-loop/switch region; other site 267671006144 TOBE-like domain; Region: TOBE_3; pfam12857 267671006145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267671006146 dimer interface [polypeptide binding]; other site 267671006147 conserved gate region; other site 267671006148 putative PBP binding loops; other site 267671006149 ABC-ATPase subunit interface; other site 267671006150 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 267671006151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267671006152 dimer interface [polypeptide binding]; other site 267671006153 conserved gate region; other site 267671006154 putative PBP binding loops; other site 267671006155 ABC-ATPase subunit interface; other site 267671006156 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 267671006157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 267671006158 substrate binding pocket [chemical binding]; other site 267671006159 membrane-bound complex binding site; other site 267671006160 hinge residues; other site 267671006161 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 267671006162 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 267671006163 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 267671006164 dimerization interface [polypeptide binding]; other site 267671006165 active site 267671006166 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 267671006167 Lumazine binding domain; Region: Lum_binding; pfam00677 267671006168 Lumazine binding domain; Region: Lum_binding; pfam00677 267671006169 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 267671006170 catalytic motif [active] 267671006171 Zn binding site [ion binding]; other site 267671006172 RibD C-terminal domain; Region: RibD_C; cl17279 267671006173 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 267671006174 Protein export membrane protein; Region: SecD_SecF; pfam02355 267671006175 protein-export membrane protein SecD; Region: secD; TIGR01129 267671006176 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 267671006177 Preprotein translocase subunit; Region: YajC; pfam02699 267671006178 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 267671006179 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 267671006180 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 267671006181 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 267671006182 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 267671006183 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 267671006184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671006185 FeS/SAM binding site; other site 267671006186 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 267671006187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671006188 non-specific DNA binding site [nucleotide binding]; other site 267671006189 salt bridge; other site 267671006190 sequence-specific DNA binding site [nucleotide binding]; other site 267671006191 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 267671006192 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 267671006193 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 267671006194 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 267671006195 AAA domain; Region: AAA_33; pfam13671 267671006196 AAA domain; Region: AAA_17; pfam13207 267671006197 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 267671006198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671006199 S-adenosylmethionine binding site [chemical binding]; other site 267671006200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671006201 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 267671006202 active site 267671006203 A new structural DNA glycosylase; Region: AlkD_like; cl11434 267671006204 active site 267671006205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671006206 Radical SAM superfamily; Region: Radical_SAM; pfam04055 267671006207 FeS/SAM binding site; other site 267671006208 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 267671006209 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 267671006210 ligand binding site [chemical binding]; other site 267671006211 NAD binding site [chemical binding]; other site 267671006212 catalytic site [active] 267671006213 homodimer interface [polypeptide binding]; other site 267671006214 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 267671006215 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 267671006216 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 267671006217 putative active site [active] 267671006218 catalytic triad [active] 267671006219 putative dimer interface [polypeptide binding]; other site 267671006220 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 267671006221 RNase_H superfamily; Region: RNase_H_2; pfam13482 267671006222 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671006223 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 267671006224 trimer interface [polypeptide binding]; other site 267671006225 active site 267671006226 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 267671006227 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 267671006228 [2Fe-2S] cluster binding site [ion binding]; other site 267671006229 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 267671006230 putative alpha subunit interface [polypeptide binding]; other site 267671006231 putative active site [active] 267671006232 putative substrate binding site [chemical binding]; other site 267671006233 Fe binding site [ion binding]; other site 267671006234 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 267671006235 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 267671006236 putative acyl-acceptor binding pocket; other site 267671006237 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 267671006238 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 267671006239 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 267671006240 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 267671006241 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 267671006242 motif 1; other site 267671006243 dimer interface [polypeptide binding]; other site 267671006244 active site 267671006245 motif 2; other site 267671006246 motif 3; other site 267671006247 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 267671006248 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 267671006249 GDP-binding site [chemical binding]; other site 267671006250 ACT binding site; other site 267671006251 IMP binding site; other site 267671006252 Predicted permeases [General function prediction only]; Region: COG0795 267671006253 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 267671006254 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 267671006255 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 267671006256 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14332 267671006257 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 267671006258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671006259 FeS/SAM binding site; other site 267671006260 TRAM domain; Region: TRAM; cl01282 267671006261 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 267671006262 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 267671006263 CoA-ligase; Region: Ligase_CoA; pfam00549 267671006264 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 267671006265 CoA binding domain; Region: CoA_binding; smart00881 267671006266 CoA-ligase; Region: Ligase_CoA; pfam00549 267671006267 Outer membrane efflux protein; Region: OEP; pfam02321 267671006268 Bacterial SH3 domain; Region: SH3_3; pfam08239 267671006269 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 267671006270 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 267671006271 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 267671006272 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 267671006273 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 267671006274 putative hydrophobic ligand binding site [chemical binding]; other site 267671006275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671006276 dimerization interface [polypeptide binding]; other site 267671006277 putative DNA binding site [nucleotide binding]; other site 267671006278 putative Zn2+ binding site [ion binding]; other site 267671006279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006280 binding surface 267671006281 TPR motif; other site 267671006282 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 267671006283 Part of AAA domain; Region: AAA_19; pfam13245 267671006284 Family description; Region: UvrD_C_2; pfam13538 267671006285 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 267671006286 dimer interface [polypeptide binding]; other site 267671006287 ADP-ribose binding site [chemical binding]; other site 267671006288 active site 267671006289 nudix motif; other site 267671006290 metal binding site [ion binding]; metal-binding site 267671006291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671006292 H+ Antiporter protein; Region: 2A0121; TIGR00900 267671006293 putative substrate translocation pore; other site 267671006294 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 267671006295 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 267671006296 Zn binding site [ion binding]; other site 267671006297 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 267671006298 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 267671006299 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671006300 Heme NO binding associated; Region: HNOBA; pfam07701 267671006301 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 267671006302 cyclase homology domain; Region: CHD; cd07302 267671006303 nucleotidyl binding site; other site 267671006304 metal binding site [ion binding]; metal-binding site 267671006305 dimer interface [polypeptide binding]; other site 267671006306 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671006307 Putative pectinesterase/pectinesterase inhibitor; Region: PLN02745 267671006308 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 267671006309 Baseplate J-like protein; Region: Baseplate_J; cl01294 267671006310 tail protein; Region: PHA00965 267671006311 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 267671006312 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 267671006313 substrate binding site; other site 267671006314 dimer interface; other site 267671006315 diaminopimelate decarboxylase; Provisional; Region: PRK11165 267671006316 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 267671006317 active site 267671006318 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267671006319 substrate binding site [chemical binding]; other site 267671006320 catalytic residues [active] 267671006321 dimer interface [polypeptide binding]; other site 267671006322 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 267671006323 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 267671006324 Transglycosylase; Region: Transgly; pfam00912 267671006325 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 267671006326 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 267671006327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 267671006328 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671006329 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 267671006330 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671006331 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 267671006332 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671006333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671006334 active site 267671006335 phosphorylation site [posttranslational modification] 267671006336 intermolecular recognition site; other site 267671006337 dimerization interface [polypeptide binding]; other site 267671006338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671006339 PAS domain; Region: PAS_9; pfam13426 267671006340 putative active site [active] 267671006341 heme pocket [chemical binding]; other site 267671006342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267671006343 Histidine kinase; Region: HisKA_2; pfam07568 267671006344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671006345 ATP binding site [chemical binding]; other site 267671006346 Mg2+ binding site [ion binding]; other site 267671006347 G-X-G motif; other site 267671006348 enoyl-CoA hydratase; Provisional; Region: PRK06142 267671006349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671006350 substrate binding site [chemical binding]; other site 267671006351 oxyanion hole (OAH) forming residues; other site 267671006352 trimer interface [polypeptide binding]; other site 267671006353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006354 binding surface 267671006355 TPR motif; other site 267671006356 TPR repeat; Region: TPR_11; pfam13414 267671006357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671006358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671006359 binding surface 267671006360 TPR motif; other site 267671006361 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 267671006362 putative catalytic site [active] 267671006363 metal binding site A [ion binding]; metal-binding site 267671006364 phosphate binding site [ion binding]; other site 267671006365 metal binding site C [ion binding]; metal-binding site 267671006366 metal binding site B [ion binding]; metal-binding site 267671006367 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 267671006368 putative catalytic site [active] 267671006369 metal binding site A [ion binding]; metal-binding site 267671006370 phosphate binding site [ion binding]; other site 267671006371 metal binding site C [ion binding]; metal-binding site 267671006372 metal binding site B [ion binding]; metal-binding site 267671006373 Uncharacterized conserved protein [Function unknown]; Region: COG5276 267671006374 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 267671006375 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 267671006376 transcription termination factor Rho; Provisional; Region: rho; PRK09376 267671006377 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 267671006378 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 267671006379 RNA binding site [nucleotide binding]; other site 267671006380 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 267671006381 multimer interface [polypeptide binding]; other site 267671006382 Walker A motif; other site 267671006383 ATP binding site [chemical binding]; other site 267671006384 Walker B motif; other site 267671006385 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 267671006386 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 267671006387 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 267671006388 trimerization site [polypeptide binding]; other site 267671006389 active site 267671006390 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 267671006391 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 267671006392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 267671006393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006394 binding surface 267671006395 TPR motif; other site 267671006396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006397 binding surface 267671006398 TPR motif; other site 267671006399 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671006400 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 267671006401 Transglycosylase; Region: Transgly; pfam00912 267671006402 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 267671006403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 267671006404 Protein of unknown function, DUF399; Region: DUF399; pfam04187 267671006405 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 267671006406 catalytic residues [active] 267671006407 dimer interface [polypeptide binding]; other site 267671006408 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 267671006409 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 267671006410 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 267671006411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671006412 putative DNA binding site [nucleotide binding]; other site 267671006413 putative Zn2+ binding site [ion binding]; other site 267671006414 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 267671006415 Catalytic site [active] 267671006416 M28 Zn-Peptidases; Region: M28_like_1; cd05640 267671006417 Peptidase family M28; Region: Peptidase_M28; pfam04389 267671006418 metal binding site [ion binding]; metal-binding site 267671006419 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 267671006420 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 267671006421 oligomeric interface; other site 267671006422 putative active site [active] 267671006423 homodimer interface [polypeptide binding]; other site 267671006424 Transposase; Region: HTH_Tnp_1; pfam01527 267671006425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 267671006426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671006427 Coenzyme A binding pocket [chemical binding]; other site 267671006428 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671006429 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 267671006430 Interdomain contacts; other site 267671006431 Cytokine receptor motif; other site 267671006432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671006433 dimerization interface [polypeptide binding]; other site 267671006434 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 267671006435 cyclase homology domain; Region: CHD; cd07302 267671006436 nucleotidyl binding site; other site 267671006437 metal binding site [ion binding]; metal-binding site 267671006438 dimer interface [polypeptide binding]; other site 267671006439 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 267671006440 Mechanosensitive ion channel; Region: MS_channel; pfam00924 267671006441 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 267671006442 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 267671006443 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 267671006444 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 267671006445 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 267671006446 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 267671006447 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846 267671006448 active site 267671006449 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 267671006450 KWG Leptospira; Region: KWG; pfam07656 267671006451 KWG Leptospira; Region: KWG; pfam07656 267671006452 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 267671006453 ThiC family; Region: ThiC; pfam01964 267671006454 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671006455 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671006456 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 267671006457 short chain dehydrogenase; Provisional; Region: PRK05872 267671006458 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 267671006459 putative NAD(P) binding site [chemical binding]; other site 267671006460 homotetramer interface [polypeptide binding]; other site 267671006461 active site 267671006462 ABC-2 type transporter; Region: ABC2_membrane; cl17235 267671006463 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 267671006464 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267671006465 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 267671006466 Walker A/P-loop; other site 267671006467 ATP binding site [chemical binding]; other site 267671006468 Q-loop/lid; other site 267671006469 ABC transporter signature motif; other site 267671006470 Walker B; other site 267671006471 D-loop; other site 267671006472 H-loop/switch region; other site 267671006473 AAA domain; Region: AAA_30; pfam13604 267671006474 AAA domain; Region: AAA_11; pfam13086 267671006475 Family description; Region: UvrD_C_2; pfam13538 267671006476 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 267671006477 Part of AAA domain; Region: AAA_19; pfam13245 267671006478 Family description; Region: UvrD_C_2; pfam13538 267671006479 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 267671006480 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 267671006481 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 267671006482 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 267671006483 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 267671006484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671006485 ATP binding site [chemical binding]; other site 267671006486 putative Mg++ binding site [ion binding]; other site 267671006487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671006488 nucleotide binding region [chemical binding]; other site 267671006489 ATP-binding site [chemical binding]; other site 267671006490 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671006491 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 267671006492 putative hydrophobic ligand binding site [chemical binding]; other site 267671006493 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 267671006494 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 267671006495 catalytic residues [active] 267671006496 Outer membrane efflux protein; Region: OEP; pfam02321 267671006497 Outer membrane efflux protein; Region: OEP; pfam02321 267671006498 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 267671006499 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 267671006500 active site 267671006501 dimer interface [polypeptide binding]; other site 267671006502 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 267671006503 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 267671006504 active site 267671006505 FMN binding site [chemical binding]; other site 267671006506 substrate binding site [chemical binding]; other site 267671006507 3Fe-4S cluster binding site [ion binding]; other site 267671006508 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 267671006509 domain interface; other site 267671006510 Rhomboid family; Region: Rhomboid; pfam01694 267671006511 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 267671006512 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 267671006513 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 267671006514 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 267671006515 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 267671006516 RNase E interface [polypeptide binding]; other site 267671006517 trimer interface [polypeptide binding]; other site 267671006518 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 267671006519 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 267671006520 RNase E interface [polypeptide binding]; other site 267671006521 trimer interface [polypeptide binding]; other site 267671006522 active site 267671006523 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 267671006524 putative nucleic acid binding region [nucleotide binding]; other site 267671006525 G-X-X-G motif; other site 267671006526 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 267671006527 RNA binding site [nucleotide binding]; other site 267671006528 domain interface; other site 267671006529 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 267671006530 16S/18S rRNA binding site [nucleotide binding]; other site 267671006531 S13e-L30e interaction site [polypeptide binding]; other site 267671006532 25S rRNA binding site [nucleotide binding]; other site 267671006533 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 267671006534 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 267671006535 active site 267671006536 Ribosome-binding factor A; Region: RBFA; pfam02033 267671006537 translation initiation factor IF-2; Region: IF-2; TIGR00487 267671006538 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 267671006539 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 267671006540 G1 box; other site 267671006541 putative GEF interaction site [polypeptide binding]; other site 267671006542 GTP/Mg2+ binding site [chemical binding]; other site 267671006543 Switch I region; other site 267671006544 G2 box; other site 267671006545 G3 box; other site 267671006546 Switch II region; other site 267671006547 G4 box; other site 267671006548 G5 box; other site 267671006549 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 267671006550 Translation-initiation factor 2; Region: IF-2; pfam11987 267671006551 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 267671006552 NusA N-terminal domain; Region: NusA_N; pfam08529 267671006553 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 267671006554 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 267671006555 RNA binding site [nucleotide binding]; other site 267671006556 homodimer interface [polypeptide binding]; other site 267671006557 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 267671006558 G-X-X-G motif; other site 267671006559 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 267671006560 G-X-X-G motif; other site 267671006561 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 267671006562 hypothetical protein; Provisional; Region: PRK14635 267671006563 ribosome maturation protein RimP; Reviewed; Region: PRK00092 267671006564 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 267671006565 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 267671006566 putative substrate binding site [chemical binding]; other site 267671006567 putative ATP binding site [chemical binding]; other site 267671006568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671006569 Coenzyme A binding pocket [chemical binding]; other site 267671006570 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 267671006571 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 267671006572 putative active site [active] 267671006573 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671006574 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 267671006575 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671006576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 267671006577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671006578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267671006579 putative substrate translocation pore; other site 267671006580 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 267671006581 TPR repeat; Region: TPR_11; pfam13414 267671006582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671006583 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 267671006584 PilZ domain; Region: PilZ; pfam07238 267671006585 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 267671006586 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 267671006587 substrate binding site [chemical binding]; other site 267671006588 oxyanion hole (OAH) forming residues; other site 267671006589 trimer interface [polypeptide binding]; other site 267671006590 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 267671006591 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 267671006592 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 267671006593 active site 267671006594 Zn binding site [ion binding]; other site 267671006595 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671006596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006597 binding surface 267671006598 Uncharacterized conserved protein [Function unknown]; Region: COG3391 267671006599 NHL repeat; Region: NHL; pfam01436 267671006600 NHL repeat; Region: NHL; pfam01436 267671006601 von Willebrand factor type A domain; Region: VWA_2; pfam13519 267671006602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006603 binding surface 267671006604 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671006605 TPR motif; other site 267671006606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006607 TPR motif; other site 267671006608 binding surface 267671006609 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 267671006610 active site 267671006611 dimer interfaces [polypeptide binding]; other site 267671006612 catalytic residues [active] 267671006613 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 267671006614 heme-binding site [chemical binding]; other site 267671006615 Methyltransferase domain; Region: Methyltransf_26; pfam13659 267671006616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 267671006617 MarR family; Region: MarR_2; pfam12802 267671006618 MarR family; Region: MarR_2; cl17246 267671006619 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 267671006620 putative active site [active] 267671006621 putative catalytic site [active] 267671006622 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 267671006623 NADH dehydrogenase subunit B; Provisional; Region: PRK14814 267671006624 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 267671006625 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 267671006626 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 267671006627 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 267671006628 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 267671006629 putative dimer interface [polypeptide binding]; other site 267671006630 [2Fe-2S] cluster binding site [ion binding]; other site 267671006631 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 267671006632 SLBB domain; Region: SLBB; pfam10531 267671006633 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 267671006634 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 267671006635 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 267671006636 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 267671006637 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 267671006638 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 267671006639 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 267671006640 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 267671006641 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 267671006642 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 267671006643 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 267671006644 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 267671006645 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671006646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671006647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671006648 DNA binding residues [nucleotide binding] 267671006649 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671006650 Leucine-rich repeats; other site 267671006651 Leucine rich repeat; Region: LRR_8; pfam13855 267671006652 Substrate binding site [chemical binding]; other site 267671006653 Leucine rich repeat; Region: LRR_8; pfam13855 267671006654 Leucine rich repeat; Region: LRR_8; pfam13855 267671006655 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 267671006656 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 267671006657 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 267671006658 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 267671006659 NAD(P) binding site [chemical binding]; other site 267671006660 catalytic residues [active] 267671006661 HDOD domain; Region: HDOD; pfam08668 267671006662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 267671006663 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 267671006664 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 267671006665 PYR/PP interface [polypeptide binding]; other site 267671006666 dimer interface [polypeptide binding]; other site 267671006667 TPP binding site [chemical binding]; other site 267671006668 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 267671006669 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 267671006670 TPP-binding site [chemical binding]; other site 267671006671 dimer interface [polypeptide binding]; other site 267671006672 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 267671006673 dimer interface [polypeptide binding]; other site 267671006674 catalytic triad [active] 267671006675 peroxidatic and resolving cysteines [active] 267671006676 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671006677 anti sigma factor interaction site; other site 267671006678 regulatory phosphorylation site [posttranslational modification]; other site 267671006679 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 267671006680 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 267671006681 active site 267671006682 (T/H)XGH motif; other site 267671006683 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 267671006684 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 267671006685 putative catalytic cysteine [active] 267671006686 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 267671006687 nucleotide binding site [chemical binding]; other site 267671006688 homotetrameric interface [polypeptide binding]; other site 267671006689 putative phosphate binding site [ion binding]; other site 267671006690 putative allosteric binding site; other site 267671006691 GTPase CgtA; Reviewed; Region: obgE; PRK12299 267671006692 GTP1/OBG; Region: GTP1_OBG; pfam01018 267671006693 Obg GTPase; Region: Obg; cd01898 267671006694 G1 box; other site 267671006695 GTP/Mg2+ binding site [chemical binding]; other site 267671006696 Switch I region; other site 267671006697 G2 box; other site 267671006698 G3 box; other site 267671006699 Switch II region; other site 267671006700 G4 box; other site 267671006701 G5 box; other site 267671006702 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 267671006703 hypothetical protein; Provisional; Region: PRK14553 267671006704 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 267671006705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671006706 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 267671006707 dimer interface [polypeptide binding]; other site 267671006708 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 267671006709 dimer interface [polypeptide binding]; other site 267671006710 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 267671006711 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 267671006712 active site 267671006713 catalytic residues [active] 267671006714 metal binding site [ion binding]; metal-binding site 267671006715 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 267671006716 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 267671006717 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14465 267671006718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671006719 FeS/SAM binding site; other site 267671006720 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 267671006721 active site 267671006722 ribulose/triose binding site [chemical binding]; other site 267671006723 phosphate binding site [ion binding]; other site 267671006724 substrate (anthranilate) binding pocket [chemical binding]; other site 267671006725 product (indole) binding pocket [chemical binding]; other site 267671006726 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671006727 anti sigma factor interaction site; other site 267671006728 regulatory phosphorylation site [posttranslational modification]; other site 267671006729 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 267671006730 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 267671006731 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 267671006732 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 267671006733 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671006734 pantothenate kinase; Reviewed; Region: PRK13318 267671006735 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 267671006736 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 267671006737 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 267671006738 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 267671006739 dimer interface [polypeptide binding]; other site 267671006740 active site 267671006741 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671006742 active site 267671006743 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 267671006744 active site 2 [active] 267671006745 active site 1 [active] 267671006746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671006747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671006748 methionine sulfoxide reductase B; Provisional; Region: PRK00222 267671006749 SelR domain; Region: SelR; pfam01641 267671006750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671006751 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 267671006752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671006753 NAD-dependent deacetylase; Provisional; Region: PRK00481 267671006754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267671006755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671006756 active site 267671006757 phosphorylation site [posttranslational modification] 267671006758 intermolecular recognition site; other site 267671006759 dimerization interface [polypeptide binding]; other site 267671006760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267671006761 DNA binding residues [nucleotide binding] 267671006762 dimerization interface [polypeptide binding]; other site 267671006763 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671006764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267671006765 Histidine kinase; Region: HisKA_3; pfam07730 267671006766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267671006767 ATP binding site [chemical binding]; other site 267671006768 Mg2+ binding site [ion binding]; other site 267671006769 G-X-G motif; other site 267671006770 Gram-negative bacterial tonB protein; Region: TonB; cl10048 267671006771 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 267671006772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671006773 Walker A motif; other site 267671006774 ATP binding site [chemical binding]; other site 267671006775 Walker B motif; other site 267671006776 arginine finger; other site 267671006777 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 267671006778 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 267671006779 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267671006780 protein binding site [polypeptide binding]; other site 267671006781 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 267671006782 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 267671006783 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 267671006784 TMP-binding site; other site 267671006785 ATP-binding site [chemical binding]; other site 267671006786 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 267671006787 TPR repeat; Region: TPR_11; pfam13414 267671006788 TPR repeat; Region: TPR_11; pfam13414 267671006789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671006790 binding surface 267671006791 TPR motif; other site 267671006792 TPR repeat; Region: TPR_11; pfam13414 267671006793 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 267671006794 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 267671006795 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 267671006796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671006797 Coenzyme A binding pocket [chemical binding]; other site 267671006798 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671006799 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 267671006800 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 267671006801 N-acetyl-D-glucosamine binding site [chemical binding]; other site 267671006802 catalytic residue [active] 267671006803 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 267671006804 dimer interface [polypeptide binding]; other site 267671006805 Citrate synthase; Region: Citrate_synt; pfam00285 267671006806 active site 267671006807 citrylCoA binding site [chemical binding]; other site 267671006808 NADH binding [chemical binding]; other site 267671006809 cationic pore residues; other site 267671006810 oxalacetate/citrate binding site [chemical binding]; other site 267671006811 coenzyme A binding site [chemical binding]; other site 267671006812 catalytic triad [active] 267671006813 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 267671006814 putative RNA binding site [nucleotide binding]; other site 267671006815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 267671006816 S-adenosylmethionine binding site [chemical binding]; other site 267671006817 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 267671006818 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 267671006819 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 267671006820 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 267671006821 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 267671006822 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 267671006823 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 267671006824 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 267671006825 Fatty acid desaturase; Region: FA_desaturase; pfam00487 267671006826 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 267671006827 putative di-iron ligands [ion binding]; other site 267671006828 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 267671006829 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 267671006830 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 267671006831 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 267671006832 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 267671006833 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 267671006834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671006835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671006836 homodimer interface [polypeptide binding]; other site 267671006837 catalytic residue [active] 267671006838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 267671006839 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671006840 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 267671006841 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 267671006842 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 267671006843 alphaNTD - beta interaction site [polypeptide binding]; other site 267671006844 alphaNTD homodimer interface [polypeptide binding]; other site 267671006845 alphaNTD - beta' interaction site [polypeptide binding]; other site 267671006846 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 267671006847 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 267671006848 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 267671006849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 267671006850 RNA binding surface [nucleotide binding]; other site 267671006851 30S ribosomal protein S11; Validated; Region: PRK05309 267671006852 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 267671006853 30S ribosomal protein S13; Region: bact_S13; TIGR03631 267671006854 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 267671006855 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 267671006856 rRNA binding site [nucleotide binding]; other site 267671006857 predicted 30S ribosome binding site; other site 267671006858 adenylate kinase; Provisional; Region: PRK14528 267671006859 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 267671006860 AMP-binding site [chemical binding]; other site 267671006861 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 267671006862 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 267671006863 SecY translocase; Region: SecY; pfam00344 267671006864 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 267671006865 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 267671006866 23S rRNA binding site [nucleotide binding]; other site 267671006867 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 267671006868 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 267671006869 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 267671006870 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 267671006871 5S rRNA interface [nucleotide binding]; other site 267671006872 L27 interface [polypeptide binding]; other site 267671006873 23S rRNA interface [nucleotide binding]; other site 267671006874 L5 interface [polypeptide binding]; other site 267671006875 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 267671006876 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 267671006877 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 267671006878 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 267671006879 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 267671006880 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 267671006881 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 267671006882 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 267671006883 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 267671006884 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 267671006885 RNA binding site [nucleotide binding]; other site 267671006886 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 267671006887 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 267671006888 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 267671006889 putative translocon interaction site; other site 267671006890 23S rRNA interface [nucleotide binding]; other site 267671006891 signal recognition particle (SRP54) interaction site; other site 267671006892 L23 interface [polypeptide binding]; other site 267671006893 trigger factor interaction site; other site 267671006894 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 267671006895 23S rRNA interface [nucleotide binding]; other site 267671006896 5S rRNA interface [nucleotide binding]; other site 267671006897 putative antibiotic binding site [chemical binding]; other site 267671006898 L25 interface [polypeptide binding]; other site 267671006899 L27 interface [polypeptide binding]; other site 267671006900 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 267671006901 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 267671006902 G-X-X-G motif; other site 267671006903 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 267671006904 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 267671006905 putative translocon binding site; other site 267671006906 protein-rRNA interface [nucleotide binding]; other site 267671006907 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 267671006908 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 267671006909 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 267671006910 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 267671006911 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 267671006912 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 267671006913 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 267671006914 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 267671006915 elongation factor Tu; Reviewed; Region: PRK00049 267671006916 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 267671006917 G1 box; other site 267671006918 GEF interaction site [polypeptide binding]; other site 267671006919 GTP/Mg2+ binding site [chemical binding]; other site 267671006920 Switch I region; other site 267671006921 G2 box; other site 267671006922 G3 box; other site 267671006923 Switch II region; other site 267671006924 G4 box; other site 267671006925 G5 box; other site 267671006926 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 267671006927 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 267671006928 Antibiotic Binding Site [chemical binding]; other site 267671006929 elongation factor G; Reviewed; Region: PRK13351 267671006930 GTP translation factor family primarily contains translation initiation, elongation and release factors; Region: GTP_translation_factor; cd00881 267671006931 G1 box; other site 267671006932 GEF interaction site [polypeptide binding]; other site 267671006933 GTP/Mg2+ binding site [chemical binding]; other site 267671006934 Switch I region; other site 267671006935 G2 box; other site 267671006936 G3 box; other site 267671006937 Switch II region; other site 267671006938 G4 box; other site 267671006939 G5 box; other site 267671006940 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 267671006941 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 267671006942 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 267671006943 putative catalytic residue [active] 267671006944 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671006945 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 267671006946 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267671006947 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 267671006948 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 267671006949 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 267671006950 ATP-grasp domain; Region: ATP-grasp_4; cl17255 267671006951 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 267671006952 IMP binding site; other site 267671006953 dimer interface [polypeptide binding]; other site 267671006954 interdomain contacts; other site 267671006955 partial ornithine binding site; other site 267671006956 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 267671006957 Sulfatase; Region: Sulfatase; pfam00884 267671006958 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 267671006959 active site 267671006960 putative DNA-binding cleft [nucleotide binding]; other site 267671006961 dimer interface [polypeptide binding]; other site 267671006962 hypothetical protein; Validated; Region: PRK00110 267671006963 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 267671006964 Integrase core domain; Region: rve_3; pfam13683 267671006965 Putative Ig domain; Region: He_PIG; pfam05345 267671006966 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 267671006967 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 267671006968 protein-splicing catalytic site; other site 267671006969 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 267671006970 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 267671006971 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671006972 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 267671006973 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 267671006974 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671006975 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 267671006976 Leucine rich repeat; Region: LRR_8; pfam13855 267671006977 Substrate binding site [chemical binding]; other site 267671006978 Leucine rich repeat; Region: LRR_8; pfam13855 267671006979 Leucine rich repeat; Region: LRR_8; pfam13855 267671006980 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 267671006981 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 267671006982 Leucine rich repeat; Region: LRR_8; pfam13855 267671006983 Leucine rich repeat; Region: LRR_8; pfam13855 267671006984 Leucine rich repeat; Region: LRR_8; pfam13855 267671006985 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 267671006986 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 267671006987 Walker A motif; other site 267671006988 ATP binding site [chemical binding]; other site 267671006989 Walker B motif; other site 267671006990 arginine finger; other site 267671006991 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 267671006992 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 267671006993 metal ion-dependent adhesion site (MIDAS); other site 267671006994 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671006995 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 267671006996 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 267671006997 Na binding site [ion binding]; other site 267671006998 aspartate kinase; Reviewed; Region: PRK06635 267671006999 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 267671007000 putative nucleotide binding site [chemical binding]; other site 267671007001 putative catalytic residues [active] 267671007002 putative Mg ion binding site [ion binding]; other site 267671007003 putative aspartate binding site [chemical binding]; other site 267671007004 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 267671007005 putative allosteric regulatory site; other site 267671007006 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 267671007007 putative allosteric regulatory residue; other site 267671007008 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 267671007009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 267671007010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 267671007011 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 267671007012 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 267671007013 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642 267671007014 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 267671007015 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 267671007016 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 267671007017 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671007018 HAMP domain; Region: HAMP; pfam00672 267671007019 dimerization interface [polypeptide binding]; other site 267671007020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671007021 SurA N-terminal domain; Region: SurA_N_3; cl07813 267671007022 putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142 267671007023 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 267671007024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671007025 FeS/SAM binding site; other site 267671007026 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 267671007027 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 267671007028 Citrate synthase; Region: Citrate_synt; pfam00285 267671007029 oxalacetate binding site [chemical binding]; other site 267671007030 citrylCoA binding site [chemical binding]; other site 267671007031 coenzyme A binding site [chemical binding]; other site 267671007032 catalytic triad [active] 267671007033 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 267671007034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 267671007035 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 267671007036 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671007037 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671007038 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 267671007039 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 267671007040 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 267671007041 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 267671007042 active site 267671007043 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 267671007044 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 267671007045 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 267671007046 HSP70 interaction site [polypeptide binding]; other site 267671007047 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671007048 anti sigma factor interaction site; other site 267671007049 regulatory phosphorylation site [posttranslational modification]; other site 267671007050 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 267671007051 excinuclease ABC subunit B; Provisional; Region: PRK05298 267671007052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671007053 ATP binding site [chemical binding]; other site 267671007054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671007055 nucleotide binding region [chemical binding]; other site 267671007056 ATP-binding site [chemical binding]; other site 267671007057 Ultra-violet resistance protein B; Region: UvrB; pfam12344 267671007058 UvrB/uvrC motif; Region: UVR; pfam02151 267671007059 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 267671007060 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 267671007061 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 267671007062 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671007063 RNA binding site [nucleotide binding]; other site 267671007064 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 267671007065 RNA binding site [nucleotide binding]; other site 267671007066 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 267671007067 RNA binding site [nucleotide binding]; other site 267671007068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 267671007069 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 267671007070 putative metal binding site; other site 267671007071 flagellin; Provisional; Region: PRK12805 267671007072 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 267671007073 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 267671007074 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 267671007075 shikimate binding site; other site 267671007076 NAD(P) binding site [chemical binding]; other site 267671007077 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 267671007078 PEGA domain; Region: PEGA; pfam08308 267671007079 PEGA domain; Region: PEGA; pfam08308 267671007080 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 267671007081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267671007082 dimer interface [polypeptide binding]; other site 267671007083 conserved gate region; other site 267671007084 putative PBP binding loops; other site 267671007085 ABC-ATPase subunit interface; other site 267671007086 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 267671007087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 267671007088 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 267671007089 active site 267671007090 phosphorylation site [posttranslational modification] 267671007091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 267671007092 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 267671007093 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 267671007094 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 267671007095 DXD motif; other site 267671007096 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 267671007097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671007098 ATP binding site [chemical binding]; other site 267671007099 putative Mg++ binding site [ion binding]; other site 267671007100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671007101 nucleotide binding region [chemical binding]; other site 267671007102 ATP-binding site [chemical binding]; other site 267671007103 RQC domain; Region: RQC; pfam09382 267671007104 HRDC domain; Region: HRDC; pfam00570 267671007105 Protein of unknown function (DUF1562); Region: DUF1562; pfam07601 267671007106 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671007107 quinolinate synthetase; Provisional; Region: PRK09375 267671007108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 267671007109 cell division protein FtsZ; Validated; Region: PRK09330 267671007110 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 267671007111 nucleotide binding site [chemical binding]; other site 267671007112 SulA interaction site; other site 267671007113 cell division protein FtsA; Region: ftsA; TIGR01174 267671007114 Cell division protein FtsA; Region: FtsA; smart00842 267671007115 Cell division protein FtsA; Region: FtsA; pfam14450 267671007116 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 267671007117 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 267671007118 mce related protein; Region: MCE; pfam02470 267671007119 hypothetical protein; Provisional; Region: PRK04164 267671007120 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 267671007121 SET domain; Region: SET; pfam00856 267671007122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671007123 S-adenosylmethionine binding site [chemical binding]; other site 267671007124 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 267671007125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671007126 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 267671007127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671007128 PAS domain; Region: PAS_9; pfam13426 267671007129 putative active site [active] 267671007130 heme pocket [chemical binding]; other site 267671007131 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 267671007132 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 267671007133 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 267671007134 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 267671007135 putative C-terminal domain interface [polypeptide binding]; other site 267671007136 putative GSH binding site (G-site) [chemical binding]; other site 267671007137 putative dimer interface [polypeptide binding]; other site 267671007138 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 267671007139 putative N-terminal domain interface [polypeptide binding]; other site 267671007140 putative dimer interface [polypeptide binding]; other site 267671007141 putative substrate binding pocket (H-site) [chemical binding]; other site 267671007142 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 267671007143 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 267671007144 metal-binding site [ion binding] 267671007145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 267671007146 Soluble P-type ATPase [General function prediction only]; Region: COG4087 267671007147 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 267671007148 metal-binding site [ion binding] 267671007149 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 267671007150 putative homodimer interface [polypeptide binding]; other site 267671007151 putative homotetramer interface [polypeptide binding]; other site 267671007152 allosteric switch controlling residues; other site 267671007153 putative metal binding site [ion binding]; other site 267671007154 putative homodimer-homodimer interface [polypeptide binding]; other site 267671007155 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671007156 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 267671007157 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 267671007158 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 267671007159 PGAP1-like protein; Region: PGAP1; pfam07819 267671007160 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 267671007161 Outer membrane efflux protein; Region: OEP; pfam02321 267671007162 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 267671007163 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 267671007164 Sulfate transporter family; Region: Sulfate_transp; pfam00916 267671007165 Protein of unknown function (DUF806); Region: DUF806; pfam05657 267671007166 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 267671007167 active site clefts [active] 267671007168 zinc binding site [ion binding]; other site 267671007169 dimer interface [polypeptide binding]; other site 267671007170 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 267671007171 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 267671007172 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 267671007173 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 267671007174 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671007175 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 267671007176 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 267671007177 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 267671007178 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 267671007179 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 267671007180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671007181 NAD(P) binding site [chemical binding]; other site 267671007182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671007183 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 267671007184 active site 267671007185 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671007186 cyclase homology domain; Region: CHD; cd07302 267671007187 nucleotidyl binding site; other site 267671007188 metal binding site [ion binding]; metal-binding site 267671007189 dimer interface [polypeptide binding]; other site 267671007190 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671007191 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671007192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671007193 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 267671007194 active site 267671007195 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 267671007196 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671007197 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671007198 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671007199 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 267671007200 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 267671007201 Haemolysin-III related; Region: HlyIII; cl03831 267671007202 YceG-like family; Region: YceG; pfam02618 267671007203 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 267671007204 dimerization interface [polypeptide binding]; other site 267671007205 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 267671007206 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 267671007207 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 267671007208 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 267671007209 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 267671007210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671007211 Coenzyme A binding pocket [chemical binding]; other site 267671007212 DJ-1 family protein; Region: not_thiJ; TIGR01383 267671007213 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 267671007214 conserved cys residue [active] 267671007215 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 267671007216 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 267671007217 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 267671007218 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671007219 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267671007220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671007221 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 267671007222 active site 267671007223 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 267671007224 Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577 267671007225 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 267671007226 active site 267671007227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 267671007228 MarR family; Region: MarR; pfam01047 267671007229 MarR family; Region: MarR_2; cl17246 267671007230 Predicted membrane protein [Function unknown]; Region: COG2259 267671007231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671007232 Coenzyme A binding pocket [chemical binding]; other site 267671007233 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 267671007234 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 267671007235 active site 267671007236 flavoprotein, HI0933 family; Region: TIGR00275 267671007237 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 267671007238 EamA-like transporter family; Region: EamA; pfam00892 267671007239 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 267671007240 trimer interface [polypeptide binding]; other site 267671007241 active site 267671007242 UDP-GlcNAc binding site [chemical binding]; other site 267671007243 lipid binding site [chemical binding]; lipid-binding site 267671007244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 267671007245 non-specific DNA binding site [nucleotide binding]; other site 267671007246 salt bridge; other site 267671007247 sequence-specific DNA binding site [nucleotide binding]; other site 267671007248 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 267671007249 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 267671007250 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 267671007251 comF family protein; Region: comF; TIGR00201 267671007252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 267671007253 active site 267671007254 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 267671007255 active site 267671007256 DNA polymerase IV; Validated; Region: PRK02406 267671007257 DNA binding site [nucleotide binding] 267671007258 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 267671007259 Fatty acid desaturase; Region: FA_desaturase; pfam00487 267671007260 putative di-iron ligands [ion binding]; other site 267671007261 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 267671007262 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671007263 ligand binding site [chemical binding]; other site 267671007264 Predicted membrane protein [Function unknown]; Region: COG4270 267671007265 hypothetical protein; Provisional; Region: PRK10318 267671007266 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007267 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007269 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007270 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671007271 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 267671007272 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 267671007273 Beta-propeller repeat; Region: SBBP; pfam06739 267671007274 Beta-propeller repeat; Region: SBBP; pfam06739 267671007275 Beta-propeller repeat; Region: SBBP; pfam06739 267671007276 Beta-propeller repeat; Region: SBBP; pfam06739 267671007277 Beta-propeller repeat; Region: SBBP; pfam06739 267671007278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007279 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671007280 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007282 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007283 PQQ-like domain; Region: PQQ_2; pfam13360 267671007284 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 267671007285 substrate binding site [chemical binding]; other site 267671007286 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 267671007287 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671007288 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671007289 cyclase homology domain; Region: CHD; cd07302 267671007290 nucleotidyl binding site; other site 267671007291 metal binding site [ion binding]; metal-binding site 267671007292 dimer interface [polypeptide binding]; other site 267671007293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671007294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671007295 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 267671007296 Protein export membrane protein; Region: SecD_SecF; cl14618 267671007297 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671007298 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671007299 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 267671007300 catalytic site [active] 267671007301 Predicted membrane protein [Function unknown]; Region: COG2259 267671007302 Pirin-related protein [General function prediction only]; Region: COG1741 267671007303 Pirin; Region: Pirin; pfam02678 267671007304 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 267671007305 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 267671007306 hydrophobic ligand binding site; other site 267671007307 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671007308 GAF domain; Region: GAF; pfam01590 267671007309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671007310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671007311 dimer interface [polypeptide binding]; other site 267671007312 phosphorylation site [posttranslational modification] 267671007313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007314 ATP binding site [chemical binding]; other site 267671007315 Mg2+ binding site [ion binding]; other site 267671007316 G-X-G motif; other site 267671007317 Response regulator receiver domain; Region: Response_reg; pfam00072 267671007318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007319 active site 267671007320 phosphorylation site [posttranslational modification] 267671007321 intermolecular recognition site; other site 267671007322 dimerization interface [polypeptide binding]; other site 267671007323 Sporulation related domain; Region: SPOR; pfam05036 267671007324 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 267671007325 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 267671007326 CoA-binding site [chemical binding]; other site 267671007327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267671007328 Histidine kinase; Region: HisKA_3; pfam07730 267671007329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007330 ATP binding site [chemical binding]; other site 267671007331 Mg2+ binding site [ion binding]; other site 267671007332 G-X-G motif; other site 267671007333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267671007334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007335 active site 267671007336 phosphorylation site [posttranslational modification] 267671007337 intermolecular recognition site; other site 267671007338 dimerization interface [polypeptide binding]; other site 267671007339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267671007340 DNA binding residues [nucleotide binding] 267671007341 dimerization interface [polypeptide binding]; other site 267671007342 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 267671007343 Protein export membrane protein; Region: SecD_SecF; cl14618 267671007344 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 267671007345 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 267671007346 tandem repeat interface [polypeptide binding]; other site 267671007347 oligomer interface [polypeptide binding]; other site 267671007348 active site residues [active] 267671007349 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 267671007350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671007351 binding surface 267671007352 TPR motif; other site 267671007353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671007354 binding surface 267671007355 TPR motif; other site 267671007356 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 267671007357 TIGR01777 family protein; Region: yfcH 267671007358 putative NAD(P) binding site [chemical binding]; other site 267671007359 putative active site [active] 267671007360 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671007361 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671007362 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671007363 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671007364 Bacterial Ig-like domain; Region: Big_5; pfam13205 267671007365 Family description; Region: VCBS; pfam13517 267671007366 FG-GAP repeat; Region: FG-GAP; pfam01839 267671007367 Family description; Region: VCBS; pfam13517 267671007368 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 267671007369 FG-GAP repeat; Region: FG-GAP; pfam01839 267671007370 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 267671007371 ligand binding site [chemical binding]; other site 267671007372 active site 267671007373 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671007374 anti sigma factor interaction site; other site 267671007375 regulatory phosphorylation site [posttranslational modification]; other site 267671007376 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 267671007377 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 267671007378 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 267671007379 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 267671007380 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 267671007381 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 267671007382 active site 267671007383 dimer interface [polypeptide binding]; other site 267671007384 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 267671007385 dimer interface [polypeptide binding]; other site 267671007386 active site 267671007387 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 267671007388 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 267671007389 Substrate binding site; other site 267671007390 metal-binding site 267671007391 Phosphotransferase enzyme family; Region: APH; pfam01636 267671007392 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 267671007393 substrate binding site [chemical binding]; other site 267671007394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007395 active site 267671007396 phosphorylation site [posttranslational modification] 267671007397 intermolecular recognition site; other site 267671007398 dimerization interface [polypeptide binding]; other site 267671007399 PAS domain; Region: PAS; smart00091 267671007400 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 267671007401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 267671007402 dimer interface [polypeptide binding]; other site 267671007403 phosphorylation site [posttranslational modification] 267671007404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007405 ATP binding site [chemical binding]; other site 267671007406 G-X-G motif; other site 267671007407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671007408 PAS domain; Region: PAS_9; pfam13426 267671007409 putative active site [active] 267671007410 heme pocket [chemical binding]; other site 267671007411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671007412 PAS domain; Region: PAS_9; pfam13426 267671007413 putative active site [active] 267671007414 heme pocket [chemical binding]; other site 267671007415 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 267671007416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671007417 dimer interface [polypeptide binding]; other site 267671007418 phosphorylation site [posttranslational modification] 267671007419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007420 ATP binding site [chemical binding]; other site 267671007421 Mg2+ binding site [ion binding]; other site 267671007422 G-X-G motif; other site 267671007423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671007424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007425 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671007426 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007428 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007429 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 267671007430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 267671007431 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 267671007432 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 267671007433 inhibitor-cofactor binding pocket; inhibition site 267671007434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671007435 catalytic residue [active] 267671007436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671007437 metal binding site [ion binding]; metal-binding site 267671007438 active site 267671007439 I-site; other site 267671007440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671007441 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 267671007442 HEAT repeats; Region: HEAT_2; pfam13646 267671007443 HEAT repeats; Region: HEAT_2; pfam13646 267671007444 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 267671007445 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671007446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 267671007447 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 267671007448 tellurium resistance terB-like protein; Region: terB_like; cl11965 267671007449 metal binding site [ion binding]; metal-binding site 267671007450 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 267671007451 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 267671007452 active site 267671007453 HIGH motif; other site 267671007454 KMSKS motif; other site 267671007455 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 267671007456 tRNA binding surface [nucleotide binding]; other site 267671007457 anticodon binding site; other site 267671007458 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 267671007459 dimer interface [polypeptide binding]; other site 267671007460 putative tRNA-binding site [nucleotide binding]; other site 267671007461 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 267671007462 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 267671007463 metal binding triad; other site 267671007464 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 267671007465 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 267671007466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671007467 Zn2+ binding site [ion binding]; other site 267671007468 Mg2+ binding site [ion binding]; other site 267671007469 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 267671007470 YceI-like domain; Region: YceI; pfam04264 267671007471 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 267671007472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671007473 NAD(P) binding site [chemical binding]; other site 267671007474 active site 267671007475 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 267671007476 Outer membrane efflux protein; Region: OEP; pfam02321 267671007477 Outer membrane efflux protein; Region: OEP; pfam02321 267671007478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671007479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671007480 active site 267671007481 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671007482 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671007483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671007484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671007485 metal binding site [ion binding]; metal-binding site 267671007486 active site 267671007487 I-site; other site 267671007488 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 267671007489 FAD binding domain; Region: FAD_binding_4; pfam01565 267671007490 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 267671007491 Protein of unknown function (DUF1567); Region: DUF1567; pfam07604 267671007492 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 267671007493 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 267671007494 Flavoprotein; Region: Flavoprotein; pfam02441 267671007495 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 267671007496 Domain of unknown function DUF21; Region: DUF21; pfam01595 267671007497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 267671007498 Transporter associated domain; Region: CorC_HlyC; smart01091 267671007499 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 267671007500 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 267671007501 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 267671007502 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 267671007503 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 267671007504 active site 267671007505 metal binding site [ion binding]; metal-binding site 267671007506 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 267671007507 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 267671007508 generic binding surface II; other site 267671007509 ssDNA binding site; other site 267671007510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671007511 ATP binding site [chemical binding]; other site 267671007512 putative Mg++ binding site [ion binding]; other site 267671007513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671007514 nucleotide binding region [chemical binding]; other site 267671007515 ATP-binding site [chemical binding]; other site 267671007516 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 267671007517 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 267671007518 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 267671007519 NAD binding site [chemical binding]; other site 267671007520 homodimer interface [polypeptide binding]; other site 267671007521 active site 267671007522 substrate binding site [chemical binding]; other site 267671007523 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 267671007524 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 267671007525 active site 267671007526 Hpt domain; Region: Hpt; pfam01627 267671007527 putative binding surface; other site 267671007528 active site 267671007529 Fic family protein [Function unknown]; Region: COG3177 267671007530 Fic/DOC family; Region: Fic; pfam02661 267671007531 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007532 Transposase; Region: DEDD_Tnp_IS110; pfam01548 267671007533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 267671007535 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 267671007536 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 267671007537 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 267671007538 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 267671007539 active site 267671007540 oligomerization interface [polypeptide binding]; other site 267671007541 metal binding site [ion binding]; metal-binding site 267671007542 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 267671007543 catalytic center binding site [active] 267671007544 ATP binding site [chemical binding]; other site 267671007545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671007546 Walker A motif; other site 267671007547 ATP binding site [chemical binding]; other site 267671007548 Walker B motif; other site 267671007549 arginine finger; other site 267671007550 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 267671007551 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 267671007552 NADP-binding site; other site 267671007553 homotetramer interface [polypeptide binding]; other site 267671007554 substrate binding site [chemical binding]; other site 267671007555 homodimer interface [polypeptide binding]; other site 267671007556 active site 267671007557 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 267671007558 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 267671007559 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671007560 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 267671007561 active site 267671007562 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 267671007563 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 267671007564 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 267671007565 TrkA-N domain; Region: TrkA_N; pfam02254 267671007566 TrkA-C domain; Region: TrkA_C; pfam02080 267671007567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 267671007568 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 267671007569 active site 267671007570 catalytic tetrad [active] 267671007571 Acylphosphatase; Region: Acylphosphatase; pfam00708 267671007572 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 267671007573 apolar tunnel; other site 267671007574 heme binding site [chemical binding]; other site 267671007575 dimerization interface [polypeptide binding]; other site 267671007576 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 267671007577 putative active site [active] 267671007578 Ap4A binding site [chemical binding]; other site 267671007579 nudix motif; other site 267671007580 putative metal binding site [ion binding]; other site 267671007581 SET domain; Region: SET; pfam00856 267671007582 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 267671007583 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 267671007584 active site 267671007585 catalytic site [active] 267671007586 metal binding site [ion binding]; metal-binding site 267671007587 dimer interface [polypeptide binding]; other site 267671007588 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 267671007589 MltA specific insert domain; Region: MltA; pfam03562 267671007590 3D domain; Region: 3D; pfam06725 267671007591 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 267671007592 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671007593 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671007594 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 267671007595 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 267671007596 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 267671007597 TrkA-C domain; Region: TrkA_C; pfam02080 267671007598 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 267671007599 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 267671007600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 267671007601 Coenzyme A binding pocket [chemical binding]; other site 267671007602 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 267671007603 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 267671007604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671007605 FeS/SAM binding site; other site 267671007606 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 267671007607 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671007608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671007609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671007610 dimer interface [polypeptide binding]; other site 267671007611 phosphorylation site [posttranslational modification] 267671007612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007613 ATP binding site [chemical binding]; other site 267671007614 Mg2+ binding site [ion binding]; other site 267671007615 G-X-G motif; other site 267671007616 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671007617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007618 active site 267671007619 phosphorylation site [posttranslational modification] 267671007620 intermolecular recognition site; other site 267671007621 dimerization interface [polypeptide binding]; other site 267671007622 GTPase RsgA; Reviewed; Region: PRK01889 267671007623 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 267671007624 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 267671007625 GTPase/Zn-binding domain interface [polypeptide binding]; other site 267671007626 GTP/Mg2+ binding site [chemical binding]; other site 267671007627 G4 box; other site 267671007628 G5 box; other site 267671007629 G1 box; other site 267671007630 Switch I region; other site 267671007631 G2 box; other site 267671007632 G3 box; other site 267671007633 Switch II region; other site 267671007634 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 267671007635 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 267671007636 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 267671007637 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 267671007638 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 267671007639 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 267671007640 Methyltransferase domain; Region: Methyltransf_12; pfam08242 267671007641 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 267671007642 putative catalytic site [active] 267671007643 metal binding site A [ion binding]; metal-binding site 267671007644 phosphate binding site [ion binding]; other site 267671007645 metal binding site C [ion binding]; metal-binding site 267671007646 metal binding site B [ion binding]; metal-binding site 267671007647 DoxX-like family; Region: DoxX_2; pfam13564 267671007648 cyclase homology domain; Region: CHD; cd07302 267671007649 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671007650 nucleotidyl binding site; other site 267671007651 metal binding site [ion binding]; metal-binding site 267671007652 dimer interface [polypeptide binding]; other site 267671007653 cyclase homology domain; Region: CHD; cd07302 267671007654 dimer interface [polypeptide binding]; other site 267671007655 nucleotidyl binding site; other site 267671007656 metal binding site [ion binding]; metal-binding site 267671007657 AAA ATPase domain; Region: AAA_16; pfam13191 267671007658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671007659 binding surface 267671007660 TPR motif; other site 267671007661 Tetratricopeptide repeat; Region: TPR_12; pfam13424 267671007662 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 267671007663 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 267671007664 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 267671007665 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 267671007666 CoenzymeA binding site [chemical binding]; other site 267671007667 subunit interaction site [polypeptide binding]; other site 267671007668 PHB binding site; other site 267671007669 Transglycosylase; Region: Transgly; pfam00912 267671007670 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 267671007671 RibD C-terminal domain; Region: RibD_C; cl17279 267671007672 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 267671007673 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 267671007674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671007675 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 267671007676 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 267671007677 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 267671007678 trimer interface [polypeptide binding]; other site 267671007679 putative metal binding site [ion binding]; other site 267671007680 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 267671007681 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 267671007682 putative tRNA-binding site [nucleotide binding]; other site 267671007683 B3/4 domain; Region: B3_4; pfam03483 267671007684 tRNA synthetase B5 domain; Region: B5; smart00874 267671007685 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 267671007686 dimer interface [polypeptide binding]; other site 267671007687 motif 1; other site 267671007688 motif 3; other site 267671007689 motif 2; other site 267671007690 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 267671007691 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 267671007692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 267671007693 ATP binding site [chemical binding]; other site 267671007694 putative Mg++ binding site [ion binding]; other site 267671007695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671007696 nucleotide binding region [chemical binding]; other site 267671007697 ATP-binding site [chemical binding]; other site 267671007698 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 267671007699 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 267671007700 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 267671007701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 267671007702 putative acyl-acceptor binding pocket; other site 267671007703 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 267671007704 dimer interface [polypeptide binding]; other site 267671007705 substrate binding site [chemical binding]; other site 267671007706 metal binding sites [ion binding]; metal-binding site 267671007707 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 267671007708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671007709 putative substrate translocation pore; other site 267671007710 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 267671007711 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 267671007712 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 267671007713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 267671007714 ATP binding site [chemical binding]; other site 267671007715 Mg++ binding site [ion binding]; other site 267671007716 motif III; other site 267671007717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 267671007718 nucleotide binding region [chemical binding]; other site 267671007719 ATP-binding site [chemical binding]; other site 267671007720 Uncharacterized conserved protein [Function unknown]; Region: COG1262 267671007721 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 267671007722 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 267671007723 short chain dehydrogenase; Provisional; Region: PRK06181 267671007724 NADP binding site [chemical binding]; other site 267671007725 homodimer interface [polypeptide binding]; other site 267671007726 substrate binding site [chemical binding]; other site 267671007727 active site 267671007728 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 267671007729 Membrane transport protein; Region: Mem_trans; pfam03547 267671007730 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671007731 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671007732 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671007733 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671007734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671007735 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671007736 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 267671007737 outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327 267671007738 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 267671007739 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 267671007740 homodimer interface [polypeptide binding]; other site 267671007741 metal binding site [ion binding]; metal-binding site 267671007742 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 267671007743 homodimer interface [polypeptide binding]; other site 267671007744 active site 267671007745 putative chemical substrate binding site [chemical binding]; other site 267671007746 metal binding site [ion binding]; metal-binding site 267671007747 Response regulator receiver domain; Region: Response_reg; pfam00072 267671007748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007749 active site 267671007750 phosphorylation site [posttranslational modification] 267671007751 intermolecular recognition site; other site 267671007752 dimerization interface [polypeptide binding]; other site 267671007753 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 267671007754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007755 active site 267671007756 phosphorylation site [posttranslational modification] 267671007757 intermolecular recognition site; other site 267671007758 dimerization interface [polypeptide binding]; other site 267671007759 isocitrate dehydrogenase; Validated; Region: PRK08299 267671007760 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671007761 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671007762 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 267671007763 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 267671007764 putative active site [active] 267671007765 catalytic triad [active] 267671007766 putative dimer interface [polypeptide binding]; other site 267671007767 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 267671007768 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 267671007769 hinge; other site 267671007770 active site 267671007771 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 267671007772 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 267671007773 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 267671007774 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 267671007775 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 267671007776 NADP binding site [chemical binding]; other site 267671007777 dimer interface [polypeptide binding]; other site 267671007778 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 267671007779 dimer interface [polypeptide binding]; other site 267671007780 [2Fe-2S] cluster binding site [ion binding]; other site 267671007781 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 267671007782 Vacuolar protein 14 C-terminal Fig4p binding; Region: Vac14_Fig4_bd; pfam11916 267671007783 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 267671007784 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 267671007785 amidophosphoribosyltransferase; Provisional; Region: PRK09123 267671007786 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 267671007787 active site 267671007788 tetramer interface [polypeptide binding]; other site 267671007789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 267671007790 active site 267671007791 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 267671007792 catalytic site [active] 267671007793 putative active site [active] 267671007794 putative substrate binding site [chemical binding]; other site 267671007795 HRDC domain; Region: HRDC; pfam00570 267671007796 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 267671007797 putative active site [active] 267671007798 putative CoA binding site [chemical binding]; other site 267671007799 nudix motif; other site 267671007800 metal binding site [ion binding]; metal-binding site 267671007801 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 267671007802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671007803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671007804 DNA binding residues [nucleotide binding] 267671007805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267671007806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007807 active site 267671007808 phosphorylation site [posttranslational modification] 267671007809 intermolecular recognition site; other site 267671007810 dimerization interface [polypeptide binding]; other site 267671007811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267671007812 DNA binding site [nucleotide binding] 267671007813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671007814 dimerization interface [polypeptide binding]; other site 267671007815 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 267671007816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671007817 dimer interface [polypeptide binding]; other site 267671007818 phosphorylation site [posttranslational modification] 267671007819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007820 ATP binding site [chemical binding]; other site 267671007821 Mg2+ binding site [ion binding]; other site 267671007822 G-X-G motif; other site 267671007823 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 267671007824 heterotetramer interface [polypeptide binding]; other site 267671007825 active site pocket [active] 267671007826 cleavage site 267671007827 Plasma-membrane choline transporter; Region: Choline_transpo; pfam04515 267671007828 GAF domain; Region: GAF; cl17456 267671007829 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671007830 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671007831 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 267671007832 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 267671007833 active site 267671007834 DUF35 OB-fold domain; Region: DUF35; pfam01796 267671007835 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 267671007836 dimer interaction site [polypeptide binding]; other site 267671007837 substrate-binding tunnel; other site 267671007838 active site 267671007839 catalytic site [active] 267671007840 substrate binding site [chemical binding]; other site 267671007841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 267671007842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 267671007843 active site 267671007844 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 267671007845 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 267671007846 nucleotide binding pocket [chemical binding]; other site 267671007847 K-X-D-G motif; other site 267671007848 catalytic site [active] 267671007849 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 267671007850 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 267671007851 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 267671007852 Dimer interface [polypeptide binding]; other site 267671007853 BRCT sequence motif; other site 267671007854 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671007855 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671007856 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671007857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671007858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 267671007859 DNA binding residues [nucleotide binding] 267671007860 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 267671007861 dimer interface [polypeptide binding]; other site 267671007862 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 267671007863 putative active site [active] 267671007864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 267671007865 Histidine kinase; Region: HisKA_2; pfam07568 267671007866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007867 Mg2+ binding site [ion binding]; other site 267671007868 G-X-G motif; other site 267671007869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 267671007870 Histidine kinase; Region: HisKA_2; pfam07568 267671007871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007872 ATP binding site [chemical binding]; other site 267671007873 Mg2+ binding site [ion binding]; other site 267671007874 G-X-G motif; other site 267671007875 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 267671007876 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 267671007877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 267671007878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 267671007879 DNA binding residues [nucleotide binding] 267671007880 dimerization interface [polypeptide binding]; other site 267671007881 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 267671007882 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 267671007883 putative ADP-ribose binding site [chemical binding]; other site 267671007884 putative active site [active] 267671007885 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671007886 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 267671007887 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 267671007888 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 267671007889 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 267671007890 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 267671007891 active site 267671007892 KWG Leptospira; Region: KWG; pfam07656 267671007893 KWG Leptospira; Region: KWG; pfam07656 267671007894 KWG Leptospira; Region: KWG; pfam07656 267671007895 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 267671007896 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671007897 active site 267671007898 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 267671007899 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 267671007900 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 267671007901 dimer interface [polypeptide binding]; other site 267671007902 motif 1; other site 267671007903 active site 267671007904 motif 2; other site 267671007905 motif 3; other site 267671007906 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 267671007907 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 267671007908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 267671007909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 267671007910 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 267671007911 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 267671007912 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 267671007913 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267671007914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 267671007915 Walker A/P-loop; other site 267671007916 ATP binding site [chemical binding]; other site 267671007917 Q-loop/lid; other site 267671007918 ABC transporter signature motif; other site 267671007919 Walker B; other site 267671007920 D-loop; other site 267671007921 H-loop/switch region; other site 267671007922 DKNYY family; Region: DKNYY; pfam13644 267671007923 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 267671007924 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 267671007925 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 267671007926 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 267671007927 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 267671007928 active site 267671007929 Zn binding site [ion binding]; other site 267671007930 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 267671007931 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 267671007932 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 267671007933 active site 267671007934 Zn binding site [ion binding]; other site 267671007935 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 267671007936 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 267671007937 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 267671007938 active site 267671007939 Zn binding site [ion binding]; other site 267671007940 argininosuccinate synthase; Provisional; Region: PRK13820 267671007941 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 267671007942 ANP binding site [chemical binding]; other site 267671007943 Substrate Binding Site II [chemical binding]; other site 267671007944 Substrate Binding Site I [chemical binding]; other site 267671007945 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 267671007946 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 267671007947 active site 267671007948 (T/H)XGH motif; other site 267671007949 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 267671007950 active site 267671007951 multimer interface [polypeptide binding]; other site 267671007952 isocitrate dehydrogenase; Validated; Region: PRK09222 267671007953 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 267671007954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671007955 Response regulator receiver domain; Region: Response_reg; pfam00072 267671007956 active site 267671007957 phosphorylation site [posttranslational modification] 267671007958 intermolecular recognition site; other site 267671007959 dimerization interface [polypeptide binding]; other site 267671007960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671007961 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 267671007962 putative active site [active] 267671007963 heme pocket [chemical binding]; other site 267671007964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671007965 putative active site [active] 267671007966 heme pocket [chemical binding]; other site 267671007967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671007968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671007969 ATP binding site [chemical binding]; other site 267671007970 Mg2+ binding site [ion binding]; other site 267671007971 G-X-G motif; other site 267671007972 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 267671007973 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 267671007974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671007975 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 267671007976 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 267671007977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671007978 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 267671007979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671007980 homodimer interface [polypeptide binding]; other site 267671007981 catalytic residue [active] 267671007982 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 267671007983 putative active site [active] 267671007984 Zn binding site [ion binding]; other site 267671007985 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 267671007986 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 267671007987 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 267671007988 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671007989 Protein of unknown function (DUF455); Region: DUF455; pfam04305 267671007990 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 267671007991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 267671007992 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 267671007993 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 267671007994 HIGH motif; other site 267671007995 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 267671007996 active site 267671007997 KMSKS motif; other site 267671007998 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 267671007999 CAP-like domain; other site 267671008000 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 267671008001 active site 267671008002 primary dimer interface [polypeptide binding]; other site 267671008003 TopoisomeraseII; Region: TOP2c; smart00433 267671008004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671008005 ATP binding site [chemical binding]; other site 267671008006 Mg2+ binding site [ion binding]; other site 267671008007 G-X-G motif; other site 267671008008 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 267671008009 ATP binding site [chemical binding]; other site 267671008010 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 267671008011 active site 267671008012 putative metal-binding site [ion binding]; other site 267671008013 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 267671008014 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 267671008015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671008016 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 267671008017 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 267671008018 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 267671008019 putative dimer interface [polypeptide binding]; other site 267671008020 active site pocket [active] 267671008021 putative cataytic base [active] 267671008022 cobalamin synthase; Reviewed; Region: cobS; PRK00235 267671008023 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267671008024 catalytic core [active] 267671008025 von Willebrand factor type A domain; Region: VWA_2; pfam13519 267671008026 metal ion-dependent adhesion site (MIDAS); other site 267671008027 conserved hypothetical protein; Region: TIGR02231 267671008028 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 267671008029 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 267671008030 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 267671008031 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 267671008032 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 267671008033 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 267671008034 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 267671008035 Cl- selectivity filter; other site 267671008036 Cl- binding residues [ion binding]; other site 267671008037 pore gating glutamate residue; other site 267671008038 dimer interface [polypeptide binding]; other site 267671008039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 267671008040 CAAX protease self-immunity; Region: Abi; pfam02517 267671008041 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671008042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 267671008043 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671008044 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 267671008045 Strictosidine synthase; Region: Str_synth; pfam03088 267671008046 sulfite reductase subunit beta; Provisional; Region: PRK13504 267671008047 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 267671008048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 267671008049 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 267671008050 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 267671008051 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 267671008052 active site 267671008053 SAM binding site [chemical binding]; other site 267671008054 homodimer interface [polypeptide binding]; other site 267671008055 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 267671008056 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 267671008057 CysD dimerization site [polypeptide binding]; other site 267671008058 G1 box; other site 267671008059 putative GEF interaction site [polypeptide binding]; other site 267671008060 GTP/Mg2+ binding site [chemical binding]; other site 267671008061 Switch I region; other site 267671008062 G2 box; other site 267671008063 G3 box; other site 267671008064 Switch II region; other site 267671008065 G4 box; other site 267671008066 G5 box; other site 267671008067 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 267671008068 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 267671008069 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 267671008070 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 267671008071 Active Sites [active] 267671008072 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 267671008073 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 267671008074 Active Sites [active] 267671008075 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 267671008076 Transposase; Region: HTH_Tnp_1; pfam01527 267671008077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671008078 putative transposase OrfB; Reviewed; Region: PHA02517 267671008079 Integrase core domain; Region: rve; pfam00665 267671008080 Integrase core domain; Region: rve_3; pfam13683 267671008081 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 267671008082 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 267671008083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267671008084 dimer interface [polypeptide binding]; other site 267671008085 conserved gate region; other site 267671008086 putative PBP binding loops; other site 267671008087 ABC-ATPase subunit interface; other site 267671008088 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 267671008089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 267671008090 dimer interface [polypeptide binding]; other site 267671008091 conserved gate region; other site 267671008092 putative PBP binding loops; other site 267671008093 ABC-ATPase subunit interface; other site 267671008094 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 267671008095 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 267671008096 Walker A/P-loop; other site 267671008097 ATP binding site [chemical binding]; other site 267671008098 Q-loop/lid; other site 267671008099 ABC transporter signature motif; other site 267671008100 Walker B; other site 267671008101 D-loop; other site 267671008102 H-loop/switch region; other site 267671008103 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 267671008104 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 267671008105 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 267671008106 Walker A/P-loop; other site 267671008107 ATP binding site [chemical binding]; other site 267671008108 Q-loop/lid; other site 267671008109 ABC transporter signature motif; other site 267671008110 Walker B; other site 267671008111 D-loop; other site 267671008112 H-loop/switch region; other site 267671008113 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 267671008114 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 267671008115 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671008116 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 267671008117 Walker A/P-loop; other site 267671008118 ATP binding site [chemical binding]; other site 267671008119 Q-loop/lid; other site 267671008120 ABC transporter signature motif; other site 267671008121 Walker B; other site 267671008122 D-loop; other site 267671008123 H-loop/switch region; other site 267671008124 Caspase domain; Region: Peptidase_C14; pfam00656 267671008125 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 267671008126 ketol-acid reductoisomerase; Provisional; Region: PRK05479 267671008127 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 267671008128 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 267671008129 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 267671008130 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671008131 dimer interface [polypeptide binding]; other site 267671008132 putative CheW interface [polypeptide binding]; other site 267671008133 OsmC-like protein; Region: OsmC; cl00767 267671008134 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 267671008135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 267671008136 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 267671008137 putative active site [active] 267671008138 putative metal binding site [ion binding]; other site 267671008139 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 267671008140 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 267671008141 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 267671008142 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 267671008143 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 267671008144 dimer interface [polypeptide binding]; other site 267671008145 putative CheW interface [polypeptide binding]; other site 267671008146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 267671008147 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671008148 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 267671008149 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 267671008150 DNA binding site [nucleotide binding] 267671008151 active site 267671008152 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 267671008153 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 267671008154 cobalamin binding residues [chemical binding]; other site 267671008155 putative BtuC binding residues; other site 267671008156 dimer interface [polypeptide binding]; other site 267671008157 acetyl-CoA synthetase; Provisional; Region: PRK00174 267671008158 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 267671008159 active site 267671008160 CoA binding site [chemical binding]; other site 267671008161 acyl-activating enzyme (AAE) consensus motif; other site 267671008162 AMP binding site [chemical binding]; other site 267671008163 acetate binding site [chemical binding]; other site 267671008164 GTP cyclohydrolase I; Provisional; Region: PLN03044 267671008165 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 267671008166 homodecamer interface [polypeptide binding]; other site 267671008167 active site 267671008168 putative catalytic site residues [active] 267671008169 zinc binding site [ion binding]; other site 267671008170 GTP-CH-I/GFRP interaction surface; other site 267671008171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671008172 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 267671008173 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 267671008174 putative hydrophobic ligand binding site [chemical binding]; other site 267671008175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671008176 dimerization interface [polypeptide binding]; other site 267671008177 putative DNA binding site [nucleotide binding]; other site 267671008178 putative Zn2+ binding site [ion binding]; other site 267671008179 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 267671008180 extended (e) SDRs; Region: SDR_e; cd08946 267671008181 NAD(P) binding site [chemical binding]; other site 267671008182 active site 267671008183 substrate binding site [chemical binding]; other site 267671008184 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 267671008185 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 267671008186 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 267671008187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 267671008188 putative acyl-acceptor binding pocket; other site 267671008189 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 267671008190 ATP-grasp domain; Region: ATP-grasp; pfam02222 267671008191 FecR protein; Region: FecR; pfam04773 267671008192 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 267671008193 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671008194 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671008195 Domain of unknown function (DUF897); Region: DUF897; pfam05982 267671008196 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 267671008197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 267671008198 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 267671008199 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 267671008200 hydrogenase 4 subunit F; Validated; Region: PRK06458 267671008201 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 267671008202 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 267671008203 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 267671008204 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 267671008205 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 267671008206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671008207 active site 267671008208 phosphorylation site [posttranslational modification] 267671008209 intermolecular recognition site; other site 267671008210 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 267671008211 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 267671008212 active site 267671008213 Fructosamine kinase; Region: Fructosamin_kin; cl17579 267671008214 Phosphotransferase enzyme family; Region: APH; pfam01636 267671008215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 267671008216 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 267671008217 Walker A/P-loop; other site 267671008218 ATP binding site [chemical binding]; other site 267671008219 Q-loop/lid; other site 267671008220 ABC transporter signature motif; other site 267671008221 Walker B; other site 267671008222 D-loop; other site 267671008223 H-loop/switch region; other site 267671008224 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 267671008225 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 267671008226 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 267671008227 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 267671008228 quinone interaction residues [chemical binding]; other site 267671008229 active site 267671008230 catalytic residues [active] 267671008231 FMN binding site [chemical binding]; other site 267671008232 substrate binding site [chemical binding]; other site 267671008233 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 267671008234 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267671008235 catalytic core [active] 267671008236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 267671008237 active site 267671008238 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 267671008239 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 267671008240 TrkA-N domain; Region: TrkA_N; pfam02254 267671008241 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 267671008242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 267671008243 MarR family; Region: MarR; pfam01047 267671008244 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 267671008245 catalytic residues [active] 267671008246 dimer interface [polypeptide binding]; other site 267671008247 intracellular protease, PfpI family; Region: PfpI; TIGR01382 267671008248 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 267671008249 conserved cys residue [active] 267671008250 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 267671008251 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 267671008252 TrkA-N domain; Region: TrkA_N; pfam02254 267671008253 Short C-terminal domain; Region: SHOCT; pfam09851 267671008254 carbon storage regulator; Provisional; Region: PRK01712 267671008255 flagellar assembly protein FliW; Provisional; Region: PRK13285 267671008256 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 267671008257 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 267671008258 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 267671008259 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 267671008260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 267671008261 FlgN protein; Region: FlgN; pfam05130 267671008262 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671008263 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671008264 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 267671008265 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 267671008266 Intermediate filament protein; Region: Filament; pfam00038 267671008267 TRL-like protein family; Region: TRL; pfam13146 267671008268 Protein of unknown function (DUF423); Region: DUF423; pfam04241 267671008269 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 267671008270 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 267671008271 active site 267671008272 Zn binding site [ion binding]; other site 267671008273 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671008274 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 267671008275 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 267671008276 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 267671008277 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 267671008278 trimer interface [polypeptide binding]; other site 267671008279 active site 267671008280 UDP-GlcNAc binding site [chemical binding]; other site 267671008281 lipid binding site [chemical binding]; lipid-binding site 267671008282 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 267671008283 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 267671008284 FAD binding pocket [chemical binding]; other site 267671008285 conserved FAD binding motif [chemical binding]; other site 267671008286 phosphate binding motif [ion binding]; other site 267671008287 beta-alpha-beta structure motif; other site 267671008288 NAD binding pocket [chemical binding]; other site 267671008289 Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229 267671008290 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 267671008291 nucleoside/Zn binding site; other site 267671008292 dimer interface [polypeptide binding]; other site 267671008293 catalytic motif [active] 267671008294 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14956 267671008295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 267671008296 Walker A motif; other site 267671008297 ATP binding site [chemical binding]; other site 267671008298 Walker B motif; other site 267671008299 arginine finger; other site 267671008300 hypothetical protein; Provisional; Region: PRK14624 267671008301 recombination protein RecR; Reviewed; Region: recR; PRK00076 267671008302 RecR protein; Region: RecR; pfam02132 267671008303 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 267671008304 putative active site [active] 267671008305 putative metal-binding site [ion binding]; other site 267671008306 tetramer interface [polypeptide binding]; other site 267671008307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 267671008308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 267671008309 substrate binding pocket [chemical binding]; other site 267671008310 membrane-bound complex binding site; other site 267671008311 hinge residues; other site 267671008312 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 267671008313 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 267671008314 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671008315 ligand binding site [chemical binding]; other site 267671008316 seryl-tRNA synthetase; Provisional; Region: PRK05431 267671008317 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 267671008318 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 267671008319 dimer interface [polypeptide binding]; other site 267671008320 active site 267671008321 motif 1; other site 267671008322 motif 2; other site 267671008323 motif 3; other site 267671008324 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 267671008325 active site 267671008326 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 267671008327 Peptidase family M23; Region: Peptidase_M23; pfam01551 267671008328 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 267671008329 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 267671008330 Protein of unknown function (DUF327); Region: DUF327; pfam03885 267671008331 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 267671008332 ParB-like nuclease domain; Region: ParB; smart00470 267671008333 KorB domain; Region: KorB; pfam08535 267671008334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 267671008335 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671008336 P-loop; other site 267671008337 Magnesium ion binding site [ion binding]; other site 267671008338 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671008339 Magnesium ion binding site [ion binding]; other site 267671008340 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 267671008341 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 267671008342 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 267671008343 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 267671008344 putative metal binding site [ion binding]; other site 267671008345 pyruvate dehydrogenase E1 component, homodimeric type; Region: aceE; TIGR00759 267671008346 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 267671008347 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 267671008348 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 267671008349 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 267671008350 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 267671008351 homodimer interface [polypeptide binding]; other site 267671008352 substrate-cofactor binding pocket; other site 267671008353 catalytic residue [active] 267671008354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 267671008355 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 267671008356 DNA polymerase III subunit delta'; Validated; Region: PRK08485 267671008357 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 267671008358 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 267671008359 FAD binding site [chemical binding]; other site 267671008360 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 267671008361 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 267671008362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 267671008363 active site 267671008364 motif I; other site 267671008365 motif II; other site 267671008366 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 267671008367 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 267671008368 NAD(P) binding pocket [chemical binding]; other site 267671008369 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 267671008370 porphobilinogen deaminase; Region: hemC; TIGR00212 267671008371 domain interfaces; other site 267671008372 active site 267671008373 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 267671008374 dimer interface [polypeptide binding]; other site 267671008375 active site 267671008376 Schiff base residues; other site 267671008377 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 267671008378 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 267671008379 inhibitor-cofactor binding pocket; inhibition site 267671008380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671008381 catalytic residue [active] 267671008382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671008383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671008384 dimer interface [polypeptide binding]; other site 267671008385 phosphorylation site [posttranslational modification] 267671008386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671008387 ATP binding site [chemical binding]; other site 267671008388 Mg2+ binding site [ion binding]; other site 267671008389 G-X-G motif; other site 267671008390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267671008391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671008392 active site 267671008393 phosphorylation site [posttranslational modification] 267671008394 intermolecular recognition site; other site 267671008395 dimerization interface [polypeptide binding]; other site 267671008396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267671008397 DNA binding site [nucleotide binding] 267671008398 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 267671008399 substrate binding site [chemical binding]; other site 267671008400 active site 267671008401 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 267671008402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 267671008403 FeS/SAM binding site; other site 267671008404 HemN C-terminal domain; Region: HemN_C; pfam06969 267671008405 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 267671008406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 267671008407 Ferrochelatase; Region: Ferrochelatase; pfam00762 267671008408 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 267671008409 active site 267671008410 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 267671008411 active site 267671008412 N-terminal domain interface [polypeptide binding]; other site 267671008413 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 267671008414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671008415 P-loop; other site 267671008416 Magnesium ion binding site [ion binding]; other site 267671008417 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671008418 Magnesium ion binding site [ion binding]; other site 267671008419 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 267671008420 ParB-like nuclease domain; Region: ParB; smart00470 267671008421 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 267671008422 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 267671008423 Acyltransferase family; Region: Acyl_transf_3; pfam01757 267671008424 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 267671008425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 267671008426 ligand binding site [chemical binding]; other site 267671008427 flexible hinge region; other site 267671008428 short chain dehydrogenase; Provisional; Region: PRK08251 267671008429 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 267671008430 putative NAD(P) binding site [chemical binding]; other site 267671008431 active site 267671008432 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 267671008433 Low molecular weight phosphatase family; Region: LMWPc; cd00115 267671008434 active site 267671008435 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 267671008436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 267671008437 short chain dehydrogenase; Provisional; Region: PRK06181 267671008438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 267671008439 NAD(P) binding site [chemical binding]; other site 267671008440 active site 267671008441 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 267671008442 putative hydrophobic ligand binding site [chemical binding]; other site 267671008443 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 267671008444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 267671008445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 267671008446 MoxR-like ATPases [General function prediction only]; Region: COG0714 267671008447 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 267671008448 Walker A motif; other site 267671008449 ATP binding site [chemical binding]; other site 267671008450 Walker B motif; other site 267671008451 arginine finger; other site 267671008452 Protein of unknown function DUF58; Region: DUF58; pfam01882 267671008453 von Willebrand factor type A domain; Region: VWA_2; pfam13519 267671008454 Aerotolerance regulator N-terminal; Region: BatA; cl06567 267671008455 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 267671008456 metal ion-dependent adhesion site (MIDAS); other site 267671008457 von Willebrand factor type A domain; Region: VWA_2; pfam13519 267671008458 metal ion-dependent adhesion site (MIDAS); other site 267671008459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671008460 binding surface 267671008461 TPR motif; other site 267671008462 TPR repeat; Region: TPR_11; pfam13414 267671008463 Oxygen tolerance; Region: BatD; pfam13584 267671008464 RecX family; Region: RecX; cl00936 267671008465 heat shock protein 90; Provisional; Region: PRK05218 267671008466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671008467 ATP binding site [chemical binding]; other site 267671008468 Mg2+ binding site [ion binding]; other site 267671008469 G-X-G motif; other site 267671008470 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 267671008471 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671008472 anti sigma factor interaction site; other site 267671008473 regulatory phosphorylation site [posttranslational modification]; other site 267671008474 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 267671008475 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 267671008476 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 267671008477 Fatty acid desaturase; Region: FA_desaturase; pfam00487 267671008478 Di-iron ligands [ion binding]; other site 267671008479 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 267671008480 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 267671008481 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 267671008482 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 267671008483 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671008484 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 267671008485 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681 267671008486 putative active site [active] 267671008487 putative substrate binding site [chemical binding]; other site 267671008488 putative coenzyme B12 binding site [chemical binding]; other site 267671008489 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 267671008490 B12 binding site [chemical binding]; other site 267671008491 cobalt ligand [ion binding]; other site 267671008492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671008493 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671008494 S-adenosylmethionine binding site [chemical binding]; other site 267671008495 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 267671008496 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 267671008497 catalytic residues [active] 267671008498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 267671008499 binding surface 267671008500 Tetratricopeptide repeat; Region: TPR_16; pfam13432 267671008501 TPR motif; other site 267671008502 TPR repeat; Region: TPR_11; pfam13414 267671008503 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 267671008504 metal binding site [ion binding]; metal-binding site 267671008505 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 267671008506 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 267671008507 NAD(P) binding site [chemical binding]; other site 267671008508 homotetramer interface [polypeptide binding]; other site 267671008509 homodimer interface [polypeptide binding]; other site 267671008510 active site 267671008511 acyl carrier protein; Provisional; Region: acpP; PRK00982 267671008512 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 267671008513 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 267671008514 dimerization interface [polypeptide binding]; other site 267671008515 active site 267671008516 metal binding site [ion binding]; metal-binding site 267671008517 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 267671008518 dsRNA binding site [nucleotide binding]; other site 267671008519 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 267671008520 nudix motif; other site 267671008521 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 267671008522 active site 267671008523 dimer interface [polypeptide binding]; other site 267671008524 metal binding site [ion binding]; metal-binding site 267671008525 Mechanosensitive ion channel; Region: MS_channel; pfam00924 267671008526 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 267671008527 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 267671008528 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 267671008529 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 267671008530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 267671008531 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 267671008532 acyl-activating enzyme (AAE) consensus motif; other site 267671008533 putative AMP binding site [chemical binding]; other site 267671008534 putative active site [active] 267671008535 putative CoA binding site [chemical binding]; other site 267671008536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 267671008537 dimerization interface [polypeptide binding]; other site 267671008538 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671008539 cyclase homology domain; Region: CHD; cd07302 267671008540 nucleotidyl binding site; other site 267671008541 metal binding site [ion binding]; metal-binding site 267671008542 dimer interface [polypeptide binding]; other site 267671008543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671008544 S-adenosylmethionine binding site [chemical binding]; other site 267671008545 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 267671008546 putative active site [active] 267671008547 putative metal binding site [ion binding]; other site 267671008548 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 267671008549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267671008550 active site 267671008551 motif I; other site 267671008552 motif II; other site 267671008553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 267671008554 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671008555 active site 267671008556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 267671008557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 267671008558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 267671008559 dimerization interface [polypeptide binding]; other site 267671008560 putative DNA binding site [nucleotide binding]; other site 267671008561 putative Zn2+ binding site [ion binding]; other site 267671008562 Methyltransferase domain; Region: Methyltransf_23; pfam13489 267671008563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671008564 S-adenosylmethionine binding site [chemical binding]; other site 267671008565 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 267671008566 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 267671008567 homotetramer interface [polypeptide binding]; other site 267671008568 ligand binding site [chemical binding]; other site 267671008569 catalytic site [active] 267671008570 NAD binding site [chemical binding]; other site 267671008571 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 267671008572 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 267671008573 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 267671008574 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 267671008575 substrate binding pocket [chemical binding]; other site 267671008576 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 267671008577 B12 binding site [chemical binding]; other site 267671008578 cobalt ligand [ion binding]; other site 267671008579 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 267671008580 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 267671008581 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 267671008582 active site 267671008583 ADP/pyrophosphate binding site [chemical binding]; other site 267671008584 dimerization interface [polypeptide binding]; other site 267671008585 allosteric effector site; other site 267671008586 fructose-1,6-bisphosphate binding site; other site 267671008587 GAF domain; Region: GAF_2; pfam13185 267671008588 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671008589 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 267671008590 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 267671008591 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671008592 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671008593 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 267671008594 homohexameric interface [polypeptide binding]; other site 267671008595 feedback inhibition sensing region; other site 267671008596 nucleotide binding site [chemical binding]; other site 267671008597 N-acetyl-L-glutamate binding site [chemical binding]; other site 267671008598 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 267671008599 classical (c) SDRs; Region: SDR_c; cd05233 267671008600 NAD(P) binding site [chemical binding]; other site 267671008601 active site 267671008602 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 267671008603 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 267671008604 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 267671008605 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 267671008606 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 267671008607 catalytic triad [active] 267671008608 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671008609 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 267671008610 cyclase homology domain; Region: CHD; cd07302 267671008611 nucleotidyl binding site; other site 267671008612 metal binding site [ion binding]; metal-binding site 267671008613 dimer interface [polypeptide binding]; other site 267671008614 Tetratricopeptide repeat; Region: TPR_2; pfam07719 267671008615 classical (c) SDRs; Region: SDR_c; cd05233 267671008616 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 267671008617 NAD(P) binding site [chemical binding]; other site 267671008618 active site 267671008619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 267671008620 active site 267671008621 DNA binding site [nucleotide binding] 267671008622 Int/Topo IB signature motif; other site 267671008623 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 267671008624 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 267671008625 ADP binding site [chemical binding]; other site 267671008626 magnesium binding site [ion binding]; other site 267671008627 putative shikimate binding site; other site 267671008628 HDOD domain; Region: HDOD; pfam08668 267671008629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 267671008630 Zn2+ binding site [ion binding]; other site 267671008631 Mg2+ binding site [ion binding]; other site 267671008632 CheD chemotactic sensory transduction; Region: CheD; cl00810 267671008633 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 267671008634 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 267671008635 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671008636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 267671008637 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671008638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 267671008639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671008640 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 267671008641 anti sigma factor interaction site; other site 267671008642 regulatory phosphorylation site [posttranslational modification]; other site 267671008643 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 267671008644 HAMP domain; Region: HAMP; pfam00672 267671008645 dimerization interface [polypeptide binding]; other site 267671008646 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 267671008647 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 267671008648 FecR protein; Region: FecR; pfam04773 267671008649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 267671008650 FecR protein; Region: FecR; pfam04773 267671008651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 267671008652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 267671008653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 267671008654 DNA binding residues [nucleotide binding] 267671008655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671008656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 267671008657 catalytic core [active] 267671008658 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 267671008659 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 267671008660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 267671008661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 267671008662 homodimer interface [polypeptide binding]; other site 267671008663 catalytic residue [active] 267671008664 cobyric acid synthase; Provisional; Region: PRK00784 267671008665 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 267671008666 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 267671008667 catalytic triad [active] 267671008668 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 267671008669 homotrimer interface [polypeptide binding]; other site 267671008670 Walker A motif; other site 267671008671 GTP binding site [chemical binding]; other site 267671008672 Walker B motif; other site 267671008673 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 267671008674 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 267671008675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 267671008676 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 267671008677 catalytic triad [active] 267671008678 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 267671008679 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 267671008680 homodimer interface [polypeptide binding]; other site 267671008681 Walker A motif; other site 267671008682 ATP binding site [chemical binding]; other site 267671008683 hydroxycobalamin binding site [chemical binding]; other site 267671008684 Walker B motif; other site 267671008685 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 267671008686 active site 267671008687 SAM binding site [chemical binding]; other site 267671008688 homodimer interface [polypeptide binding]; other site 267671008689 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 267671008690 active site 267671008691 SAM binding site [chemical binding]; other site 267671008692 homodimer interface [polypeptide binding]; other site 267671008693 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 267671008694 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 267671008695 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 267671008696 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 267671008697 active site 267671008698 SAM binding site [chemical binding]; other site 267671008699 homodimer interface [polypeptide binding]; other site 267671008700 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 267671008701 active site 267671008702 putative homodimer interface [polypeptide binding]; other site 267671008703 SAM binding site [chemical binding]; other site 267671008704 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 267671008705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671008706 Precorrin-8X methylmutase; Region: CbiC; pfam02570 267671008707 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 267671008708 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 267671008709 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 267671008710 FAD binding pocket [chemical binding]; other site 267671008711 conserved FAD binding motif [chemical binding]; other site 267671008712 phosphate binding motif [ion binding]; other site 267671008713 beta-alpha-beta structure motif; other site 267671008714 NAD binding pocket [chemical binding]; other site 267671008715 Protein of unknown function (DUF3209); Region: DUF3209; pfam11483 267671008716 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 267671008717 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 267671008718 putative active site [active] 267671008719 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 267671008720 putative active site [active] 267671008721 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 267671008722 dimer interface [polypeptide binding]; other site 267671008723 [2Fe-2S] cluster binding site [ion binding]; other site 267671008724 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 267671008725 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 267671008726 NAD(P) binding site [chemical binding]; other site 267671008727 homodimer interface [polypeptide binding]; other site 267671008728 substrate binding site [chemical binding]; other site 267671008729 active site 267671008730 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 267671008731 heat shock protein HtpX; Provisional; Region: PRK05457 267671008732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 267671008733 active site 267671008734 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 267671008735 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 267671008736 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267671008737 protein binding site [polypeptide binding]; other site 267671008738 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 267671008739 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 267671008740 protein binding site [polypeptide binding]; other site 267671008741 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 267671008742 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 267671008743 metal binding site 2 [ion binding]; metal-binding site 267671008744 putative DNA binding helix; other site 267671008745 metal binding site 1 [ion binding]; metal-binding site 267671008746 dimer interface [polypeptide binding]; other site 267671008747 structural Zn2+ binding site [ion binding]; other site 267671008748 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 267671008749 heme binding pocket [chemical binding]; other site 267671008750 heme ligand [chemical binding]; other site 267671008751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 267671008752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 267671008753 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 267671008754 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 267671008755 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 267671008756 N-terminal plug; other site 267671008757 ligand-binding site [chemical binding]; other site 267671008758 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 267671008759 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 267671008760 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 267671008761 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 267671008762 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 267671008763 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 267671008764 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 267671008765 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 267671008766 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 267671008767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 267671008768 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671008769 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 267671008770 catalytic triad [active] 267671008771 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671008772 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 267671008773 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 267671008774 homodimer interface [polypeptide binding]; other site 267671008775 metal binding site [ion binding]; metal-binding site 267671008776 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 267671008777 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 267671008778 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 267671008779 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 267671008780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 267671008781 S-adenosylmethionine binding site [chemical binding]; other site 267671008782 Protease prsW family; Region: PrsW-protease; pfam13367 267671008783 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 267671008784 Putative Ig domain; Region: He_PIG; pfam05345 267671008785 Putative Ig domain; Region: He_PIG; pfam05345 267671008786 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671008787 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 267671008788 Helix-turn-helix domain; Region: HTH_18; pfam12833 267671008789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 267671008790 Response regulator receiver domain; Region: Response_reg; pfam00072 267671008791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671008792 active site 267671008793 phosphorylation site [posttranslational modification] 267671008794 intermolecular recognition site; other site 267671008795 dimerization interface [polypeptide binding]; other site 267671008796 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 267671008797 nucleotidyl binding site; other site 267671008798 metal binding site [ion binding]; metal-binding site 267671008799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 267671008800 Cache domain; Region: Cache_1; pfam02743 267671008801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671008802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671008803 metal binding site [ion binding]; metal-binding site 267671008804 active site 267671008805 I-site; other site 267671008806 Cache domain; Region: Cache_1; pfam02743 267671008807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 267671008808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 267671008809 metal binding site [ion binding]; metal-binding site 267671008810 active site 267671008811 I-site; other site 267671008812 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 267671008813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671008814 dimer interface [polypeptide binding]; other site 267671008815 phosphorylation site [posttranslational modification] 267671008816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671008817 ATP binding site [chemical binding]; other site 267671008818 Mg2+ binding site [ion binding]; other site 267671008819 G-X-G motif; other site 267671008820 Response regulator receiver domain; Region: Response_reg; pfam00072 267671008821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671008822 active site 267671008823 phosphorylation site [posttranslational modification] 267671008824 intermolecular recognition site; other site 267671008825 dimerization interface [polypeptide binding]; other site 267671008826 FecR protein; Region: FecR; pfam04773 267671008827 Patatin-like phospholipase; Region: Patatin; pfam01734 267671008828 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 267671008829 Na binding site [ion binding]; other site 267671008830 putative glycosylation site [posttranslational modification]; other site 267671008831 putative glycosylation site [posttranslational modification]; other site 267671008832 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 267671008833 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 267671008834 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 267671008835 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 267671008836 active site 267671008837 nucleophile elbow; other site 267671008838 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 267671008839 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 267671008840 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 267671008841 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 267671008842 active site 267671008843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 267671008844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 267671008845 active site 267671008846 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 267671008847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 267671008848 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 267671008849 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 267671008850 Sodium Bile acid symporter family; Region: SBF; pfam01758 267671008851 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 267671008852 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 267671008853 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 267671008854 catalytic residue [active] 267671008855 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 267671008856 diiron binding motif [ion binding]; other site 267671008857 YhhN-like protein; Region: YhhN; pfam07947 267671008858 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 267671008859 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 267671008860 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 267671008861 heterodimer interface [polypeptide binding]; other site 267671008862 substrate interaction site [chemical binding]; other site 267671008863 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 267671008864 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 267671008865 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 267671008866 active site 267671008867 substrate binding site [chemical binding]; other site 267671008868 coenzyme B12 binding site [chemical binding]; other site 267671008869 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 267671008870 B12 binding site [chemical binding]; other site 267671008871 cobalt ligand [ion binding]; other site 267671008872 membrane ATPase/protein kinase; Provisional; Region: PRK09435 267671008873 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 267671008874 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 267671008875 Walker A; other site 267671008876 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 267671008877 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 267671008878 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 267671008879 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 267671008880 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 267671008881 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 267671008882 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 267671008883 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 267671008884 putative active site [active] 267671008885 putative metal binding site [ion binding]; other site 267671008886 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 267671008887 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 267671008888 active site 267671008889 FMN binding site [chemical binding]; other site 267671008890 substrate binding site [chemical binding]; other site 267671008891 3Fe-4S cluster binding site [ion binding]; other site 267671008892 Yip1 domain; Region: Yip1; pfam04893 267671008893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 267671008894 active site 267671008895 PAS domain S-box; Region: sensory_box; TIGR00229 267671008896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 267671008897 putative active site [active] 267671008898 heme pocket [chemical binding]; other site 267671008899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671008900 dimer interface [polypeptide binding]; other site 267671008901 phosphorylation site [posttranslational modification] 267671008902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 267671008903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671008904 ATP binding site [chemical binding]; other site 267671008905 Mg2+ binding site [ion binding]; other site 267671008906 G-X-G motif; other site 267671008907 short chain dehydrogenase; Provisional; Region: PRK07454 267671008908 classical (c) SDRs; Region: SDR_c; cd05233 267671008909 NAD(P) binding site [chemical binding]; other site 267671008910 active site 267671008911 methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328 267671008912 intersubunit interface [polypeptide binding]; other site 267671008913 active site 267671008914 Zn2+ binding site [ion binding]; other site 267671008915 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 267671008916 Cupin domain; Region: Cupin_2; pfam07883 267671008917 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 267671008918 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 267671008919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 267671008920 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 267671008921 Predicted membrane protein [Function unknown]; Region: COG1238 267671008922 internal repeat sequences detected; contains internal repeats as detected by prospero conserved hypothetical protein; this region contains an authentic frameshift, and is not the result of a sequencing artifact 267671008923 SET domain; Region: SET; cl02566 267671008924 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 267671008925 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 267671008926 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 267671008927 alanine racemase; Reviewed; Region: alr; PRK00053 267671008928 active site 267671008929 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 267671008930 dimer interface [polypeptide binding]; other site 267671008931 substrate binding site [chemical binding]; other site 267671008932 catalytic residues [active] 267671008933 Phosphate acyltransferases; Region: PlsC; smart00563 267671008934 putative acyl-acceptor binding pocket; other site 267671008935 Sec24-related protein; Provisional; Region: PTZ00395 267671008936 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 267671008937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 267671008938 dimer interface [polypeptide binding]; other site 267671008939 phosphorylation site [posttranslational modification] 267671008940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 267671008941 ATP binding site [chemical binding]; other site 267671008942 Mg2+ binding site [ion binding]; other site 267671008943 G-X-G motif; other site 267671008944 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 267671008945 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 267671008946 N-acetyl-D-glucosamine binding site [chemical binding]; other site 267671008947 catalytic residue [active] 267671008948 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 267671008949 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 267671008950 substrate binding site [chemical binding]; other site 267671008951 ligand binding site [chemical binding]; other site 267671008952 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 267671008953 substrate binding site [chemical binding]; other site 267671008954 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 267671008955 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 267671008956 ligand binding site [chemical binding]; other site 267671008957 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 267671008958 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 267671008959 motif 1; other site 267671008960 dimer interface [polypeptide binding]; other site 267671008961 active site 267671008962 motif 2; other site 267671008963 motif 3; other site 267671008964 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 267671008965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 267671008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 267671008967 active site 267671008968 phosphorylation site [posttranslational modification] 267671008969 intermolecular recognition site; other site 267671008970 dimerization interface [polypeptide binding]; other site 267671008971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 267671008972 DNA binding site [nucleotide binding] 267671008973 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 267671008974 aromatic arch; other site 267671008975 DCoH dimer interaction site [polypeptide binding]; other site 267671008976 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 267671008977 DCoH tetramer interaction site [polypeptide binding]; other site 267671008978 substrate binding site [chemical binding]; other site 267671008979 phosphodiesterase; Provisional; Region: PRK12704 267671008980 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 267671008981 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 267671008982 pyruvate kinase; Provisional; Region: PRK05826 267671008983 domain interfaces; other site 267671008984 active site 267671008985 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 267671008986 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 267671008987 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 267671008988 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 267671008989 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 267671008990 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671008991 P-loop; other site 267671008992 Magnesium ion binding site [ion binding]; other site 267671008993 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 267671008994 Magnesium ion binding site [ion binding]; other site 267671008995 ParB-like nuclease domain; Region: ParB; smart00470 267671008996 Helix-turn-helix domain; Region: HTH_36; pfam13730