-- dump date 20140619_131300 -- class Genbank::misc_feature -- table misc_feature_note -- id note 189518000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 189518000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 189518000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518000004 Walker A motif; other site 189518000005 ATP binding site [chemical binding]; other site 189518000006 Walker B motif; other site 189518000007 arginine finger; other site 189518000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 189518000009 DnaA box-binding interface [nucleotide binding]; other site 189518000010 DNA polymerase III subunit beta; Provisional; Region: PRK14942 189518000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 189518000012 putative DNA binding surface [nucleotide binding]; other site 189518000013 dimer interface [polypeptide binding]; other site 189518000014 beta-clamp/clamp loader binding surface; other site 189518000015 beta-clamp/translesion DNA polymerase binding surface; other site 189518000016 recombination protein F; Reviewed; Region: recF; PRK00064 189518000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518000018 Walker A/P-loop; other site 189518000019 ATP binding site [chemical binding]; other site 189518000020 Q-loop/lid; other site 189518000021 ABC transporter signature motif; other site 189518000022 Walker B; other site 189518000023 D-loop; other site 189518000024 H-loop/switch region; other site 189518000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 189518000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 189518000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518000028 ATP binding site [chemical binding]; other site 189518000029 Mg2+ binding site [ion binding]; other site 189518000030 G-X-G motif; other site 189518000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 189518000032 anchoring element; other site 189518000033 dimer interface [polypeptide binding]; other site 189518000034 ATP binding site [chemical binding]; other site 189518000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 189518000036 active site 189518000037 putative metal-binding site [ion binding]; other site 189518000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 189518000039 DNA gyrase subunit A; Validated; Region: PRK05560 189518000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 189518000041 CAP-like domain; other site 189518000042 active site 189518000043 primary dimer interface [polypeptide binding]; other site 189518000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189518000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189518000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189518000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189518000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 189518000049 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 189518000050 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 189518000051 FMN binding site [chemical binding]; other site 189518000052 active site 189518000053 catalytic residues [active] 189518000054 substrate binding site [chemical binding]; other site 189518000055 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 189518000056 metal ion-dependent adhesion site (MIDAS); other site 189518000057 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 189518000058 Sigma-54 interaction domain; Region: Sigma54_activ_2; pfam14532 189518000059 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 189518000060 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 189518000061 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 189518000062 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 189518000063 active site 189518000064 dimer interface [polypeptide binding]; other site 189518000065 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189518000066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518000067 NAD(P) binding site [chemical binding]; other site 189518000068 active site 189518000069 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 189518000070 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518000071 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518000072 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518000073 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518000074 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518000075 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518000076 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 189518000077 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 189518000078 putative ArsC-like catalytic residues; other site 189518000079 putative TRX-like catalytic residues [active] 189518000080 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 189518000081 FliG N-terminal domain; Region: FliG_N; pfam14842 189518000082 FliG middle domain; Region: FliG_M; pfam14841 189518000083 FliG C-terminal domain; Region: FliG_C; pfam01706 189518000084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518000085 cyclase homology domain; Region: CHD; cd07302 189518000086 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518000087 nucleotidyl binding site; other site 189518000088 metal binding site [ion binding]; metal-binding site 189518000089 dimer interface [polypeptide binding]; other site 189518000090 hypothetical protein; Provisional; Region: PRK10318 189518000091 Protein of unknown function (DUF989); Region: DUF989; pfam06181 189518000092 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 189518000093 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 189518000094 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 189518000095 active site 189518000096 dimerization interface [polypeptide binding]; other site 189518000097 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 189518000098 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 189518000099 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 189518000100 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 189518000101 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 189518000102 dimerization interface [polypeptide binding]; other site 189518000103 domain crossover interface; other site 189518000104 redox-dependent activation switch; other site 189518000105 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 189518000106 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 189518000107 Glycoprotease family; Region: Peptidase_M22; pfam00814 189518000108 ribonuclease R; Region: RNase_R; TIGR02063 189518000109 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 189518000110 RNB domain; Region: RNB; pfam00773 189518000111 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518000112 RNA binding site [nucleotide binding]; other site 189518000113 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 189518000114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518000115 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189518000116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000117 binding surface 189518000118 TPR repeat; Region: TPR_11; pfam13414 189518000119 TPR motif; other site 189518000120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000121 binding surface 189518000122 TPR motif; other site 189518000123 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518000124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000125 binding surface 189518000126 TPR motif; other site 189518000127 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 189518000128 active site 189518000129 catalytic residue [active] 189518000130 dimer interface [polypeptide binding]; other site 189518000131 KpsF/GutQ family protein; Region: kpsF; TIGR00393 189518000132 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 189518000133 putative active site [active] 189518000134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 189518000135 transcriptional activator RfaH; Region: RfaH; TIGR01955 189518000136 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 189518000137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518000138 PAS fold; Region: PAS_3; pfam08447 189518000139 putative active site [active] 189518000140 heme pocket [chemical binding]; other site 189518000141 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189518000142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518000143 dimer interface [polypeptide binding]; other site 189518000144 putative CheW interface [polypeptide binding]; other site 189518000145 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 189518000146 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 189518000147 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189518000148 NAD binding site [chemical binding]; other site 189518000149 putative substrate binding site 2 [chemical binding]; other site 189518000150 putative substrate binding site 1 [chemical binding]; other site 189518000151 active site 189518000152 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 189518000153 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 189518000154 ligand binding site [chemical binding]; other site 189518000155 homodimer interface [polypeptide binding]; other site 189518000156 NAD(P) binding site [chemical binding]; other site 189518000157 trimer interface B [polypeptide binding]; other site 189518000158 trimer interface A [polypeptide binding]; other site 189518000159 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 189518000160 active site 189518000161 histidyl-tRNA synthetase; Region: hisS; TIGR00442 189518000162 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 189518000163 dimer interface [polypeptide binding]; other site 189518000164 motif 1; other site 189518000165 active site 189518000166 motif 2; other site 189518000167 motif 3; other site 189518000168 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 189518000169 anticodon binding site; other site 189518000170 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 189518000171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 189518000172 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 189518000173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518000174 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 189518000175 ligand binding site [chemical binding]; other site 189518000176 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 189518000177 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 189518000178 substrate binding pocket [chemical binding]; other site 189518000179 dimer interface [polypeptide binding]; other site 189518000180 inhibitor binding site; inhibition site 189518000181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000182 binding surface 189518000183 TPR motif; other site 189518000184 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518000185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000186 binding surface 189518000187 TPR motif; other site 189518000188 TPR repeat; Region: TPR_11; pfam13414 189518000189 TPR repeat; Region: TPR_11; pfam13414 189518000190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000191 TPR motif; other site 189518000192 binding surface 189518000193 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 189518000194 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 189518000195 Sporulation related domain; Region: SPOR; pfam05036 189518000196 serine O-acetyltransferase; Region: cysE; TIGR01172 189518000197 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 189518000198 trimer interface [polypeptide binding]; other site 189518000199 active site 189518000200 substrate binding site [chemical binding]; other site 189518000201 CoA binding site [chemical binding]; other site 189518000202 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 189518000203 Peptidase family M50; Region: Peptidase_M50; pfam02163 189518000204 active site 189518000205 putative substrate binding region [chemical binding]; other site 189518000206 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189518000207 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 189518000208 putative efflux protein, MATE family; Region: matE; TIGR00797 189518000209 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 189518000210 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 189518000211 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189518000212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518000213 dimerization interface [polypeptide binding]; other site 189518000214 Extracellular mutant protein 11; Region: ECM11; pfam15463 189518000215 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518000216 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518000217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000218 binding surface 189518000219 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518000220 TPR motif; other site 189518000221 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518000222 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 189518000223 Zn binding site [ion binding]; other site 189518000224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518000225 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 189518000226 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189518000227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518000228 dimerization interface [polypeptide binding]; other site 189518000229 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518000230 TPR repeat; Region: TPR_11; pfam13414 189518000231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000232 binding surface 189518000233 TPR motif; other site 189518000234 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518000235 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 189518000236 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 189518000237 trimer interface [polypeptide binding]; other site 189518000238 active site 189518000239 enoyl-CoA hydratase; Provisional; Region: PRK07657 189518000240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518000241 substrate binding site [chemical binding]; other site 189518000242 oxyanion hole (OAH) forming residues; other site 189518000243 trimer interface [polypeptide binding]; other site 189518000244 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 189518000245 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189518000246 active site 189518000247 metal binding site [ion binding]; metal-binding site 189518000248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189518000249 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 189518000250 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 189518000251 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 189518000252 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 189518000253 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518000254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000255 S-adenosylmethionine binding site [chemical binding]; other site 189518000256 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 189518000257 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 189518000258 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 189518000259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189518000260 putative acyl-acceptor binding pocket; other site 189518000261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518000262 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518000263 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518000264 Uncharacterized conserved protein [Function unknown]; Region: COG5439 189518000265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 189518000266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518000267 Mg2+ binding site [ion binding]; other site 189518000268 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 189518000269 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 189518000270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000271 S-adenosylmethionine binding site [chemical binding]; other site 189518000272 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 189518000273 catalytic triad [active] 189518000274 HEAT repeats; Region: HEAT_2; pfam13646 189518000275 HEAT repeats; Region: HEAT_2; pfam13646 189518000276 HEAT repeats; Region: HEAT_2; pfam13646 189518000277 HEAT repeats; Region: HEAT_2; pfam13646 189518000278 HEAT repeats; Region: HEAT_2; pfam13646 189518000279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189518000280 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189518000281 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 189518000282 acyl-activating enzyme (AAE) consensus motif; other site 189518000283 putative AMP binding site [chemical binding]; other site 189518000284 putative active site [active] 189518000285 putative CoA binding site [chemical binding]; other site 189518000286 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 189518000287 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 189518000288 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 189518000289 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 189518000290 aminodeoxychorismate synthase; Provisional; Region: PRK07508 189518000291 chorismate binding enzyme; Region: Chorismate_bind; cl10555 189518000292 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 189518000293 homodimer interface [polypeptide binding]; other site 189518000294 substrate-cofactor binding pocket; other site 189518000295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518000296 catalytic residue [active] 189518000297 MASE1; Region: MASE1; pfam05231 189518000298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518000299 Histidine kinase; Region: HisKA_2; pfam07568 189518000300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518000301 ATP binding site [chemical binding]; other site 189518000302 Mg2+ binding site [ion binding]; other site 189518000303 G-X-G motif; other site 189518000304 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 189518000305 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518000306 catalytic residue [active] 189518000307 peptide chain release factor 1; Validated; Region: prfA; PRK00591 189518000308 PCRF domain; Region: PCRF; pfam03462 189518000309 RF-1 domain; Region: RF-1; pfam00472 189518000310 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 189518000311 active site 189518000312 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 189518000313 nudix motif; other site 189518000314 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 189518000315 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 189518000316 putative active site pocket [active] 189518000317 4-fold oligomerization interface [polypeptide binding]; other site 189518000318 metal binding residues [ion binding]; metal-binding site 189518000319 3-fold/trimer interface [polypeptide binding]; other site 189518000320 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 189518000321 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 189518000322 putative active site [active] 189518000323 oxyanion strand; other site 189518000324 catalytic triad [active] 189518000325 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 189518000326 catalytic residues [active] 189518000327 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 189518000328 putative active site [active] 189518000329 redox center [active] 189518000330 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 189518000331 Thioredoxin; Region: Thioredoxin_4; pfam13462 189518000332 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 189518000333 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 189518000334 dimer interface [polypeptide binding]; other site 189518000335 substrate binding site [chemical binding]; other site 189518000336 ATP binding site [chemical binding]; other site 189518000337 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 189518000338 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 189518000339 DNA binding site [nucleotide binding] 189518000340 active site 189518000341 GAF domain; Region: GAF_3; pfam13492 189518000342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518000343 dimer interface [polypeptide binding]; other site 189518000344 phosphorylation site [posttranslational modification] 189518000345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518000346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518000347 ATP binding site [chemical binding]; other site 189518000348 Mg2+ binding site [ion binding]; other site 189518000349 G-X-G motif; other site 189518000350 GTPase RsgA; Reviewed; Region: PRK00098 189518000351 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518000352 RNA binding site [nucleotide binding]; other site 189518000353 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 189518000354 GTPase/Zn-binding domain interface [polypeptide binding]; other site 189518000355 GTP/Mg2+ binding site [chemical binding]; other site 189518000356 G4 box; other site 189518000357 G5 box; other site 189518000358 G1 box; other site 189518000359 Switch I region; other site 189518000360 G2 box; other site 189518000361 G3 box; other site 189518000362 Switch II region; other site 189518000363 FecR protein; Region: FecR; pfam04773 189518000364 PEGA domain; Region: PEGA; pfam08308 189518000365 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 189518000366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000367 binding surface 189518000368 TPR motif; other site 189518000369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000370 binding surface 189518000371 TPR motif; other site 189518000372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000373 TPR motif; other site 189518000374 binding surface 189518000375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000376 binding surface 189518000377 TPR motif; other site 189518000378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000379 binding surface 189518000380 TPR motif; other site 189518000381 TPR repeat; Region: TPR_11; pfam13414 189518000382 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 189518000383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000384 TPR motif; other site 189518000385 binding surface 189518000386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000387 binding surface 189518000388 TPR motif; other site 189518000389 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 189518000390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000391 S-adenosylmethionine binding site [chemical binding]; other site 189518000392 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 189518000393 PilZ domain; Region: PilZ; pfam07238 189518000394 MAEBL; Provisional; Region: PTZ00121 189518000395 Predicted GTPase [General function prediction only]; Region: COG0218 189518000396 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 189518000397 G1 box; other site 189518000398 GTP/Mg2+ binding site [chemical binding]; other site 189518000399 Switch I region; other site 189518000400 G2 box; other site 189518000401 G3 box; other site 189518000402 Switch II region; other site 189518000403 G4 box; other site 189518000404 G5 box; other site 189518000405 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 189518000406 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 189518000407 Ligand Binding Site [chemical binding]; other site 189518000408 GAF domain; Region: GAF_2; pfam13185 189518000409 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 189518000410 GAF domain; Region: GAF; pfam01590 189518000411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518000412 Walker A motif; other site 189518000413 ATP binding site [chemical binding]; other site 189518000414 Walker B motif; other site 189518000415 arginine finger; other site 189518000416 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 189518000417 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 189518000418 SET domain; Region: SET; pfam00856 189518000419 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189518000420 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189518000421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518000422 Walker A/P-loop; other site 189518000423 ATP binding site [chemical binding]; other site 189518000424 Q-loop/lid; other site 189518000425 ABC transporter signature motif; other site 189518000426 Walker B; other site 189518000427 D-loop; other site 189518000428 H-loop/switch region; other site 189518000429 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 189518000430 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 189518000431 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 189518000432 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 189518000433 Tetramer interface [polypeptide binding]; other site 189518000434 active site 189518000435 FMN-binding site [chemical binding]; other site 189518000436 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 189518000437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189518000438 catalytic loop [active] 189518000439 iron binding site [ion binding]; other site 189518000440 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 189518000441 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 189518000442 Molybdopterin oxidoreductase; Region: Molybdopterin; pfam00384 189518000443 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 189518000444 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 189518000445 Protein of unknown function (DUF433); Region: DUF433; pfam04255 189518000446 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 189518000447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518000448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 189518000449 DNA binding residues [nucleotide binding] 189518000450 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 189518000451 catalytic residues [active] 189518000452 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 189518000453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518000454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518000455 homodimer interface [polypeptide binding]; other site 189518000456 catalytic residue [active] 189518000457 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 189518000458 hypothetical protein; Provisional; Region: PRK14391 189518000459 membrane protein insertase; Provisional; Region: PRK01318 189518000460 YidC periplasmic domain; Region: YidC_periplas; pfam14849 189518000461 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 189518000462 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 189518000463 Jag N-terminus; Region: Jag_N; pfam14804 189518000464 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 189518000465 G-X-X-G motif; other site 189518000466 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 189518000467 RxxxH motif; other site 189518000468 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 189518000469 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 189518000470 trmE is a tRNA modification GTPase; Region: trmE; cd04164 189518000471 G1 box; other site 189518000472 GTP/Mg2+ binding site [chemical binding]; other site 189518000473 Switch I region; other site 189518000474 G2 box; other site 189518000475 Switch II region; other site 189518000476 G3 box; other site 189518000477 G4 box; other site 189518000478 G5 box; other site 189518000479 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 189518000480 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 189518000481 Malic enzyme, N-terminal domain; Region: malic; pfam00390 189518000482 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 189518000483 putative NAD(P) binding site [chemical binding]; other site 189518000484 fumarate hydratase; Reviewed; Region: fumC; PRK00485 189518000485 Class II fumarases; Region: Fumarase_classII; cd01362 189518000486 active site 189518000487 tetramer interface [polypeptide binding]; other site 189518000488 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 189518000489 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 189518000490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518000491 non-specific DNA binding site [nucleotide binding]; other site 189518000492 salt bridge; other site 189518000493 sequence-specific DNA binding site [nucleotide binding]; other site 189518000494 Helix-turn-helix domain; Region: HTH_17; pfam12728 189518000495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518000496 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518000497 SEC7 domain proteins [General function prediction only]; Region: COG5307 189518000498 Omptin family; Region: Omptin; cl01886 189518000499 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 189518000500 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518000501 ligand binding site [chemical binding]; other site 189518000502 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 189518000503 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189518000504 RNA binding surface [nucleotide binding]; other site 189518000505 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 189518000506 active site 189518000507 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 189518000508 putative active site [active] 189518000509 catalytic triad [active] 189518000510 putative dimer interface [polypeptide binding]; other site 189518000511 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 189518000512 classical (c) SDRs; Region: SDR_c; cd05233 189518000513 NAD(P) binding site [chemical binding]; other site 189518000514 active site 189518000515 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 189518000516 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 189518000517 Uncharacterized conserved protein [Function unknown]; Region: COG3339 189518000518 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 189518000519 active site 189518000520 dimerization interface [polypeptide binding]; other site 189518000521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518000522 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 189518000523 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518000524 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 189518000525 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518000526 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 189518000527 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 189518000528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518000529 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189518000530 NAD(P) binding site [chemical binding]; other site 189518000531 active site 189518000532 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 189518000533 putative active site [active] 189518000534 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 189518000535 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 189518000536 Cu(I) binding site [ion binding]; other site 189518000537 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 189518000538 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 189518000539 Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_2; cd13915 189518000540 CuA binuclear center [ion binding]; other site 189518000541 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 189518000542 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 189518000543 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 189518000544 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 189518000545 Subunit I/III interface [polypeptide binding]; other site 189518000546 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 189518000547 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 189518000548 putative active site [active] 189518000549 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 189518000550 active site 189518000551 substrate-binding site [chemical binding]; other site 189518000552 metal-binding site [ion binding] 189518000553 ATP binding site [chemical binding]; other site 189518000554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 189518000555 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189518000556 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189518000557 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189518000558 P-loop; other site 189518000559 Magnesium ion binding site [ion binding]; other site 189518000560 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 189518000561 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 189518000562 GatB domain; Region: GatB_Yqey; pfam02637 189518000563 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 189518000564 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 189518000565 active site 189518000566 PHP Thumb interface [polypeptide binding]; other site 189518000567 metal binding site [ion binding]; metal-binding site 189518000568 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 189518000569 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 189518000570 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 189518000571 generic binding surface I; other site 189518000572 generic binding surface II; other site 189518000573 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518000574 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518000575 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189518000576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518000577 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518000578 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518000579 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 189518000580 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 189518000581 FtsX-like permease family; Region: FtsX; pfam02687 189518000582 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189518000583 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 189518000584 Walker A/P-loop; other site 189518000585 ATP binding site [chemical binding]; other site 189518000586 Q-loop/lid; other site 189518000587 ABC transporter signature motif; other site 189518000588 Walker B; other site 189518000589 D-loop; other site 189518000590 H-loop/switch region; other site 189518000591 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 189518000592 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518000593 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518000594 ligand binding site [chemical binding]; other site 189518000595 flexible hinge region; other site 189518000596 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518000597 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 189518000598 ligand binding site [chemical binding]; other site 189518000599 flexible hinge region; other site 189518000600 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 189518000601 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189518000602 minor groove reading motif; other site 189518000603 helix-hairpin-helix signature motif; other site 189518000604 substrate binding pocket [chemical binding]; other site 189518000605 active site 189518000606 Beta-propeller repeat; Region: SBBP; pfam06739 189518000607 Beta-propeller repeat; Region: SBBP; pfam06739 189518000608 Beta-propeller repeat; Region: SBBP; pfam06739 189518000609 Beta-propeller repeat; Region: SBBP; pfam06739 189518000610 Beta-propeller repeat; Region: SBBP; pfam06739 189518000611 Beta-propeller repeat; Region: SBBP; pfam06739 189518000612 Beta-propeller repeat; Region: SBBP; pfam06739 189518000613 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 189518000614 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518000615 cyclase homology domain; Region: CHD; cd07302 189518000616 nucleotidyl binding site; other site 189518000617 metal binding site [ion binding]; metal-binding site 189518000618 dimer interface [polypeptide binding]; other site 189518000619 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 189518000620 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518000621 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518000622 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518000623 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 189518000624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000625 S-adenosylmethionine binding site [chemical binding]; other site 189518000626 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 189518000627 P-loop containing region of AAA domain; Region: AAA_29; cl17516 189518000628 AAA domain; Region: AAA_23; pfam13476 189518000629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518000630 ABC transporter signature motif; other site 189518000631 Walker B; other site 189518000632 D-loop; other site 189518000633 H-loop/switch region; other site 189518000634 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 189518000635 active site 189518000636 metal binding site [ion binding]; metal-binding site 189518000637 DNA binding site [nucleotide binding] 189518000638 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 189518000639 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 189518000640 putative NAD(P) binding site [chemical binding]; other site 189518000641 FOG: CBS domain [General function prediction only]; Region: COG0517 189518000642 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803 189518000643 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 189518000644 HSP70 interaction site [polypeptide binding]; other site 189518000645 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 189518000646 Carbon starvation protein CstA; Region: CstA; pfam02554 189518000647 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 189518000648 Nudix N-terminal; Region: Nudix_N_2; pfam14803 189518000649 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 189518000650 nudix motif; other site 189518000651 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 189518000652 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 189518000653 ligand binding site [chemical binding]; other site 189518000654 NRDE protein; Region: NRDE; cl01315 189518000655 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 189518000656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518000657 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518000658 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518000659 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 189518000660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000661 S-adenosylmethionine binding site [chemical binding]; other site 189518000662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518000663 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 189518000664 ligand binding site [chemical binding]; other site 189518000665 flexible hinge region; other site 189518000666 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518000667 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518000668 ligand binding site [chemical binding]; other site 189518000669 flexible hinge region; other site 189518000670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 189518000671 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189518000672 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 189518000673 active site 189518000674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518000675 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518000676 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 189518000677 elongation factor G; Reviewed; Region: PRK12740 189518000678 G1 box; other site 189518000679 putative GEF interaction site [polypeptide binding]; other site 189518000680 GTP/Mg2+ binding site [chemical binding]; other site 189518000681 Switch I region; other site 189518000682 G2 box; other site 189518000683 G3 box; other site 189518000684 Switch II region; other site 189518000685 G4 box; other site 189518000686 G5 box; other site 189518000687 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 189518000688 Elongation Factor G, domain II; Region: EFG_II; pfam14492 189518000689 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 189518000690 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 189518000691 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 189518000692 Cation transport protein; Region: TrkH; cl17365 189518000693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189518000694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518000695 non-specific DNA binding site [nucleotide binding]; other site 189518000696 salt bridge; other site 189518000697 sequence-specific DNA binding site [nucleotide binding]; other site 189518000698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518000699 non-specific DNA binding site [nucleotide binding]; other site 189518000700 salt bridge; other site 189518000701 sequence-specific DNA binding site [nucleotide binding]; other site 189518000702 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 189518000703 putative active site [active] 189518000704 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 189518000705 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 189518000706 putative hydrophobic ligand binding site [chemical binding]; other site 189518000707 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 189518000708 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189518000709 putative NAD(P) binding site [chemical binding]; other site 189518000710 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189518000711 substrate binding pocket [chemical binding]; other site 189518000712 chain length determination region; other site 189518000713 substrate-Mg2+ binding site; other site 189518000714 catalytic residues [active] 189518000715 aspartate-rich region 1; other site 189518000716 active site lid residues [active] 189518000717 aspartate-rich region 2; other site 189518000718 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 189518000719 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189518000720 RNA binding surface [nucleotide binding]; other site 189518000721 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 189518000722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000723 S-adenosylmethionine binding site [chemical binding]; other site 189518000724 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189518000725 Penicillin amidase; Region: Penicil_amidase; pfam01804 189518000726 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 189518000727 active site 189518000728 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 189518000729 active site 189518000730 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 189518000731 Ligand Binding Site [chemical binding]; other site 189518000732 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 189518000733 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 189518000734 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 189518000735 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 189518000736 active site 189518000737 catalytic site [active] 189518000738 metal binding site [ion binding]; metal-binding site 189518000739 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 189518000740 Uncharacterized conserved protein [Function unknown]; Region: COG3791 189518000741 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12729 189518000742 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 189518000743 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 189518000744 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 189518000745 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12624 189518000746 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 189518000747 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518000748 anti sigma factor interaction site; other site 189518000749 regulatory phosphorylation site [posttranslational modification]; other site 189518000750 TPR repeat; Region: TPR_11; pfam13414 189518000751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000752 binding surface 189518000753 TPR motif; other site 189518000754 TPR repeat; Region: TPR_11; pfam13414 189518000755 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 189518000756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 189518000757 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 189518000758 glycine dehydrogenase; Provisional; Region: PRK05367 189518000759 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 189518000760 tetramer interface [polypeptide binding]; other site 189518000761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518000762 catalytic residue [active] 189518000763 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 189518000764 tetramer interface [polypeptide binding]; other site 189518000765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518000766 catalytic residue [active] 189518000767 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 189518000768 lipoyl attachment site [posttranslational modification]; other site 189518000769 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 189518000770 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 189518000771 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 189518000772 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 189518000773 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 189518000774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518000775 catalytic residue [active] 189518000776 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 189518000777 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 189518000778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000779 binding surface 189518000780 TPR motif; other site 189518000781 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518000782 Sulfatase; Region: Sulfatase; cl19157 189518000783 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 189518000784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000785 binding surface 189518000786 TPR motif; other site 189518000787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000788 binding surface 189518000789 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 189518000790 TPR motif; other site 189518000791 Methyltransferase domain; Region: Methyltransf_18; pfam12847 189518000792 WG containing repeat; Region: WG_beta_rep; pfam14903 189518000793 WG containing repeat; Region: WG_beta_rep; pfam14903 189518000794 WG containing repeat; Region: WG_beta_rep; pfam14903 189518000795 WG containing repeat; Region: WG_beta_rep; pfam14903 189518000796 WG containing repeat; Region: WG_beta_rep; pfam14903 189518000797 Bacterial sugar transferase; Region: Bac_transf; pfam02397 189518000798 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 189518000799 dinuclear metal binding motif [ion binding]; other site 189518000800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518000801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518000802 active site 189518000803 phosphorylation site [posttranslational modification] 189518000804 intermolecular recognition site; other site 189518000805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 189518000806 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 189518000807 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 189518000808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518000809 FeS/SAM binding site; other site 189518000810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000811 binding surface 189518000812 TPR motif; other site 189518000813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000814 TPR motif; other site 189518000815 binding surface 189518000816 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 189518000817 Clp amino terminal domain; Region: Clp_N; pfam02861 189518000818 Clp amino terminal domain; Region: Clp_N; pfam02861 189518000819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518000820 Walker A motif; other site 189518000821 ATP binding site [chemical binding]; other site 189518000822 Walker B motif; other site 189518000823 arginine finger; other site 189518000824 UvrB/uvrC motif; Region: UVR; pfam02151 189518000825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518000826 Walker A motif; other site 189518000827 ATP binding site [chemical binding]; other site 189518000828 Walker B motif; other site 189518000829 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 189518000830 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 189518000831 phosphagen binding site; other site 189518000832 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 189518000833 catalytic residues [active] 189518000834 Int/Topo IB signature motif; other site 189518000835 DNA binding site [nucleotide binding] 189518000836 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518000837 anti sigma factor interaction site; other site 189518000838 regulatory phosphorylation site [posttranslational modification]; other site 189518000839 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 189518000840 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 189518000841 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189518000842 active site 189518000843 catalytic triad [active] 189518000844 oxyanion hole [active] 189518000845 Strictosidine synthase; Region: Str_synth; cl19733 189518000846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189518000847 catalytic core [active] 189518000848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189518000849 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189518000850 Walker A/P-loop; other site 189518000851 ATP binding site [chemical binding]; other site 189518000852 Q-loop/lid; other site 189518000853 ABC transporter signature motif; other site 189518000854 Walker B; other site 189518000855 D-loop; other site 189518000856 H-loop/switch region; other site 189518000857 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 189518000858 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 189518000859 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518000860 Zn2+ binding site [ion binding]; other site 189518000861 Mg2+ binding site [ion binding]; other site 189518000862 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 189518000863 Competence protein; Region: Competence; pfam03772 189518000864 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 189518000865 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 189518000866 active site 189518000867 HIGH motif; other site 189518000868 dimer interface [polypeptide binding]; other site 189518000869 KMSKS motif; other site 189518000870 Invariant surface glycoprotein; Region: ISG65-75; cl19916 189518000871 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 189518000872 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 189518000873 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 189518000874 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 189518000875 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 189518000876 Ligand binding site [chemical binding]; other site 189518000877 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 189518000878 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518000879 active site 189518000880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518000881 S-adenosylmethionine binding site [chemical binding]; other site 189518000882 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 189518000883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518000884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518000885 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518000886 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518000887 Putative Ig domain; Region: He_PIG; pfam05345 189518000888 Putative Ig domain; Region: He_PIG; pfam05345 189518000889 Beta-propeller repeat; Region: SBBP; pfam06739 189518000890 Beta-propeller repeat; Region: SBBP; pfam06739 189518000891 Beta-propeller repeat; Region: SBBP; pfam06739 189518000892 Beta-propeller repeat; Region: SBBP; pfam06739 189518000893 Beta-propeller repeat; Region: SBBP; pfam06739 189518000894 Beta-propeller repeat; Region: SBBP; pfam06739 189518000895 Beta-propeller repeat; Region: SBBP; pfam06739 189518000896 Beta-propeller repeat; Region: SBBP; pfam06739 189518000897 Beta-propeller repeat; Region: SBBP; pfam06739 189518000898 Beta-propeller repeat; Region: SBBP; pfam06739 189518000899 Beta-propeller repeat; Region: SBBP; pfam06739 189518000900 Beta-propeller repeat; Region: SBBP; pfam06739 189518000901 Beta-propeller repeat; Region: SBBP; pfam06739 189518000902 Beta-propeller repeat; Region: SBBP; pfam06739 189518000903 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 189518000904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518000905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518000906 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518000907 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 189518000908 Transcriptional regulator PadR-like family; Region: PadR; cl17335 189518000909 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 189518000910 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518000911 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518000912 active site 189518000913 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 189518000914 Sm and related proteins; Region: Sm_like; cl00259 189518000915 Sm1 motif; other site 189518000916 hexamer interface [polypeptide binding]; other site 189518000917 heptamer interface [polypeptide binding]; other site 189518000918 RNA binding site [nucleotide binding]; other site 189518000919 Sm2 motif; other site 189518000920 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189518000921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518000922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518000923 DNA binding residues [nucleotide binding] 189518000924 FecR protein; Region: FecR; pfam04773 189518000925 DoxX; Region: DoxX; pfam07681 189518000926 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189518000927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518000928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518000929 Walker A/P-loop; other site 189518000930 ATP binding site [chemical binding]; other site 189518000931 Q-loop/lid; other site 189518000932 ABC transporter signature motif; other site 189518000933 Walker B; other site 189518000934 D-loop; other site 189518000935 ABC transporter; Region: ABC_tran_2; pfam12848 189518000936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518000937 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 189518000938 active site residue [active] 189518000939 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 189518000940 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 189518000941 putative active site [active] 189518000942 putative metal binding site [ion binding]; other site 189518000943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518000944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518000945 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518000946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518000947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518000948 WHG domain; Region: WHG; pfam13305 189518000949 putative acyltransferase; Provisional; Region: PRK05790 189518000950 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189518000951 dimer interface [polypeptide binding]; other site 189518000952 active site 189518000953 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 189518000954 amidase catalytic site [active] 189518000955 Zn binding residues [ion binding]; other site 189518000956 substrate binding site [chemical binding]; other site 189518000957 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 189518000958 amidase catalytic site [active] 189518000959 Zn binding residues [ion binding]; other site 189518000960 substrate binding site [chemical binding]; other site 189518000961 chromosome segregation protein; Provisional; Region: PRK03918 189518000962 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 189518000963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000964 binding surface 189518000965 TPR motif; other site 189518000966 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518000967 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 189518000968 homopentamer interface [polypeptide binding]; other site 189518000969 active site 189518000970 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 189518000971 putative RNA binding site [nucleotide binding]; other site 189518000972 TPR repeat; Region: TPR_11; pfam13414 189518000973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000974 TPR motif; other site 189518000975 binding surface 189518000976 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 189518000977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000978 binding surface 189518000979 TPR motif; other site 189518000980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000981 binding surface 189518000982 TPR motif; other site 189518000983 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 189518000984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518000985 binding surface 189518000986 HEAT repeats; Region: HEAT_2; pfam13646 189518000987 HEAT repeats; Region: HEAT_2; pfam13646 189518000988 HEAT repeats; Region: HEAT_2; pfam13646 189518000989 HEAT repeats; Region: HEAT_2; pfam13646 189518000990 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 189518000991 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 189518000992 active site 189518000993 catalytic residues [active] 189518000994 metal binding site [ion binding]; metal-binding site 189518000995 HEAT repeats; Region: HEAT_2; pfam13646 189518000996 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 189518000997 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 189518000998 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189518000999 NAD(P) binding site [chemical binding]; other site 189518001000 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189518001001 Predicted transcriptional regulator [Transcription]; Region: COG2378 189518001002 WYL domain; Region: WYL; pfam13280 189518001003 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 189518001004 Part of AAA domain; Region: AAA_19; pfam13245 189518001005 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 189518001006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001007 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001008 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001009 hypothetical protein; Provisional; Region: PRK10318 189518001010 Predicted membrane protein [Function unknown]; Region: COG4270 189518001011 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 189518001012 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518001013 ligand binding site [chemical binding]; other site 189518001014 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 189518001015 putative di-iron ligands [ion binding]; other site 189518001016 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 189518001017 active site 189518001018 DNA polymerase IV; Validated; Region: PRK02406 189518001019 DNA binding site [nucleotide binding] 189518001020 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 189518001021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189518001022 active site 189518001023 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 189518001024 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 189518001025 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 189518001026 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189518001027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518001028 non-specific DNA binding site [nucleotide binding]; other site 189518001029 salt bridge; other site 189518001030 sequence-specific DNA binding site [nucleotide binding]; other site 189518001031 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 189518001032 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 189518001033 trimer interface [polypeptide binding]; other site 189518001034 active site 189518001035 UDP-GlcNAc binding site [chemical binding]; other site 189518001036 lipid binding site [chemical binding]; lipid-binding site 189518001037 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 189518001038 EamA-like transporter family; Region: EamA; pfam00892 189518001039 EamA-like transporter family; Region: EamA; pfam00892 189518001040 flavoprotein, HI0933 family; Region: TIGR00275 189518001041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518001042 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189518001043 active site 189518001044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518001045 Coenzyme A binding pocket [chemical binding]; other site 189518001046 Predicted membrane protein [Function unknown]; Region: COG2259 189518001047 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189518001048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189518001049 Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577 189518001050 active site 189518001051 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 189518001052 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 189518001053 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 189518001054 active site 189518001055 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 189518001056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518001057 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 189518001058 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 189518001059 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 189518001060 DJ-1 family protein; Region: not_thiJ; TIGR01383 189518001061 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 189518001062 conserved cys residue [active] 189518001063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518001064 Coenzyme A binding pocket [chemical binding]; other site 189518001065 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 189518001066 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 189518001067 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518001068 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 189518001069 ligand binding site [chemical binding]; other site 189518001070 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518001071 MMPL family; Region: MMPL; cl14618 189518001072 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 189518001073 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 189518001074 dimerization interface [polypeptide binding]; other site 189518001075 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 189518001076 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 189518001077 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518001078 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518001079 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518001080 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518001081 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 189518001082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518001083 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189518001084 active site 189518001085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001086 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001088 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518001089 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518001090 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518001091 cyclase homology domain; Region: CHD; cd07302 189518001092 nucleotidyl binding site; other site 189518001093 metal binding site [ion binding]; metal-binding site 189518001094 dimer interface [polypeptide binding]; other site 189518001095 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189518001096 classical (c) SDRs; Region: SDR_c; cd05233 189518001097 NAD(P) binding site [chemical binding]; other site 189518001098 active site 189518001099 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 189518001100 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 189518001101 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 189518001102 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 189518001103 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 189518001104 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518001105 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 189518001106 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 189518001107 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 189518001108 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 189518001109 Sulfate transporter family; Region: Sulfate_transp; cl19250 189518001110 Protein of unknown function (DUF806); Region: DUF806; pfam05657 189518001111 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 189518001112 active site clefts [active] 189518001113 zinc binding site [ion binding]; other site 189518001114 dimer interface [polypeptide binding]; other site 189518001115 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 189518001116 Outer membrane efflux protein; Region: OEP; pfam02321 189518001117 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 189518001118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001119 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001120 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001121 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518001122 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189518001123 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 189518001124 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 189518001125 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518001126 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 189518001127 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518001128 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 189518001129 putative homodimer interface [polypeptide binding]; other site 189518001130 putative homotetramer interface [polypeptide binding]; other site 189518001131 allosteric switch controlling residues; other site 189518001132 putative metal binding site [ion binding]; other site 189518001133 putative homodimer-homodimer interface [polypeptide binding]; other site 189518001134 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189518001135 metal-binding site [ion binding] 189518001136 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 189518001137 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 189518001138 metal-binding site [ion binding] 189518001139 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189518001140 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189518001141 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 189518001142 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 189518001143 putative C-terminal domain interface [polypeptide binding]; other site 189518001144 putative GSH binding site (G-site) [chemical binding]; other site 189518001145 putative dimer interface [polypeptide binding]; other site 189518001146 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 189518001147 putative N-terminal domain interface [polypeptide binding]; other site 189518001148 putative dimer interface [polypeptide binding]; other site 189518001149 putative substrate binding pocket (H-site) [chemical binding]; other site 189518001150 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 189518001151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518001152 PAS domain; Region: PAS_9; pfam13426 189518001153 putative active site [active] 189518001154 heme pocket [chemical binding]; other site 189518001155 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 189518001156 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 189518001157 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 189518001158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189518001159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518001160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518001161 S-adenosylmethionine binding site [chemical binding]; other site 189518001162 SET domain; Region: SET; pfam00856 189518001163 hypothetical protein; Provisional; Region: PRK04164 189518001164 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 189518001165 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 189518001166 mce related protein; Region: MCE; pfam02470 189518001167 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 189518001168 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 189518001169 cell division protein FtsA; Region: ftsA; TIGR01174 189518001170 Cell division protein FtsA; Region: FtsA; smart00842 189518001171 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 189518001172 nucleotide binding site [chemical binding]; other site 189518001173 Cell division protein FtsA; Region: FtsA; pfam14450 189518001174 cell division protein FtsZ; Validated; Region: PRK09330 189518001175 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 189518001176 nucleotide binding site [chemical binding]; other site 189518001177 SulA interaction site; other site 189518001178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001179 TPR motif; other site 189518001180 Quinolinate synthetase A protein; Region: NadA; pfam02445 189518001181 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518001182 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 189518001183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518001184 ATP binding site [chemical binding]; other site 189518001185 putative Mg++ binding site [ion binding]; other site 189518001186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518001187 nucleotide binding region [chemical binding]; other site 189518001188 ATP-binding site [chemical binding]; other site 189518001189 RQC domain; Region: RQC; pfam09382 189518001190 HRDC domain; Region: HRDC; pfam00570 189518001191 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 189518001192 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189518001193 DXD motif; other site 189518001194 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 189518001195 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 189518001196 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 189518001197 active site 189518001198 phosphorylation site [posttranslational modification] 189518001199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 189518001200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 189518001201 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 189518001202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189518001203 dimer interface [polypeptide binding]; other site 189518001204 conserved gate region; other site 189518001205 putative PBP binding loops; other site 189518001206 ABC-ATPase subunit interface; other site 189518001207 PEGA domain; Region: PEGA; pfam08308 189518001208 PEGA domain; Region: PEGA; pfam08308 189518001209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001210 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001211 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001212 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 189518001213 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 189518001214 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 189518001215 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 189518001216 shikimate binding site; other site 189518001217 NAD(P) binding site [chemical binding]; other site 189518001218 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 189518001219 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 189518001220 putative metal binding site; other site 189518001221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 189518001222 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 189518001223 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518001224 RNA binding site [nucleotide binding]; other site 189518001225 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 189518001226 RNA binding site [nucleotide binding]; other site 189518001227 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 189518001228 RNA binding site [nucleotide binding]; other site 189518001229 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 189518001230 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189518001231 excinuclease ABC subunit B; Provisional; Region: PRK05298 189518001232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518001233 ATP binding site [chemical binding]; other site 189518001234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518001235 nucleotide binding region [chemical binding]; other site 189518001236 ATP-binding site [chemical binding]; other site 189518001237 Ultra-violet resistance protein B; Region: UvrB; pfam12344 189518001238 UvrB/uvrC motif; Region: UVR; pfam02151 189518001239 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 189518001240 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518001241 anti sigma factor interaction site; other site 189518001242 regulatory phosphorylation site [posttranslational modification]; other site 189518001243 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 189518001244 HSP70 interaction site [polypeptide binding]; other site 189518001245 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 189518001246 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 189518001247 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189518001248 active site 189518001249 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 189518001250 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518001251 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518001252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189518001253 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 189518001254 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 189518001255 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 189518001256 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 189518001257 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 189518001258 oxalacetate binding site [chemical binding]; other site 189518001259 citrylCoA binding site [chemical binding]; other site 189518001260 coenzyme A binding site [chemical binding]; other site 189518001261 catalytic triad [active] 189518001262 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 189518001263 ligand binding site; other site 189518001264 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 189518001265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518001266 FeS/SAM binding site; other site 189518001267 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 189518001268 SurA N-terminal domain; Region: SurA_N_3; cl07813 189518001269 putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142 189518001270 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 189518001271 Cache domain; Region: Cache_1; pfam02743 189518001272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518001273 dimerization interface [polypeptide binding]; other site 189518001274 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518001275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518001276 dimer interface [polypeptide binding]; other site 189518001277 putative CheW interface [polypeptide binding]; other site 189518001278 Cache domain; Region: Cache_1; pfam02743 189518001279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518001280 dimerization interface [polypeptide binding]; other site 189518001281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518001282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518001283 dimer interface [polypeptide binding]; other site 189518001284 putative CheW interface [polypeptide binding]; other site 189518001285 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 189518001286 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 189518001287 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 189518001288 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642 189518001289 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 189518001290 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 189518001291 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 189518001292 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 189518001293 aspartate kinase; Reviewed; Region: PRK06635 189518001294 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 189518001295 putative nucleotide binding site [chemical binding]; other site 189518001296 putative catalytic residues [active] 189518001297 putative Mg ion binding site [ion binding]; other site 189518001298 putative aspartate binding site [chemical binding]; other site 189518001299 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 189518001300 putative allosteric regulatory site; other site 189518001301 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 189518001302 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 189518001303 Na binding site [ion binding]; other site 189518001304 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518001305 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 189518001306 metal ion-dependent adhesion site (MIDAS); other site 189518001307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518001308 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189518001309 Walker A motif; other site 189518001310 ATP binding site [chemical binding]; other site 189518001311 Walker B motif; other site 189518001312 arginine finger; other site 189518001313 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 189518001314 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518001315 Leucine rich repeat; Region: LRR_8; pfam13855 189518001316 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518001317 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518001318 Leucine rich repeat; Region: LRR_8; pfam13855 189518001319 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518001320 Leucine rich repeat; Region: LRR_8; pfam13855 189518001321 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518001322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001323 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001324 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001325 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 189518001326 Protein of unknown function (DUF342); Region: DUF342; cl19219 189518001327 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518001328 Leucine rich repeat; Region: LRR_8; pfam13855 189518001329 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518001330 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 189518001331 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 189518001332 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 189518001333 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160 189518001334 Pretoxin HINT domain; Region: PT-HINT; pfam07591 189518001335 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 189518001336 protein-splicing catalytic site; other site 189518001337 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518001338 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 189518001339 Putative Ig domain; Region: He_PIG; pfam05345 189518001340 Integrase core domain; Region: rve_3; pfam13683 189518001341 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 189518001342 hypothetical protein; Validated; Region: PRK00110 189518001343 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 189518001344 active site 189518001345 putative DNA-binding cleft [nucleotide binding]; other site 189518001346 dimer interface [polypeptide binding]; other site 189518001347 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 189518001348 Sulfatase; Region: Sulfatase; pfam00884 189518001349 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 189518001350 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189518001351 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518001352 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 189518001353 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189518001354 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518001355 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 189518001356 IMP binding site; other site 189518001357 dimer interface [polypeptide binding]; other site 189518001358 interdomain contacts; other site 189518001359 partial ornithine binding site; other site 189518001360 Immunity protein 46; Region: Imm46; pfam15585 189518001361 Immunity protein 46; Region: Imm46; pfam15585 189518001362 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518001363 pantothenate kinase; Provisional; Region: PTZ00297 189518001364 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 189518001365 putative catalytic residue [active] 189518001366 elongation factor G; Reviewed; Region: PRK13351 189518001367 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 189518001368 G1 box; other site 189518001369 GTP/Mg2+ binding site [chemical binding]; other site 189518001370 G2 box; other site 189518001371 Switch I region; other site 189518001372 G3 box; other site 189518001373 Switch II region; other site 189518001374 G4 box; other site 189518001375 G5 box; other site 189518001376 Elongation Factor G, domain II; Region: EFG_II; pfam14492 189518001377 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514 189518001378 elongation factor Tu; Reviewed; Region: PRK00049 189518001379 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 189518001380 G1 box; other site 189518001381 GEF interaction site [polypeptide binding]; other site 189518001382 GTP/Mg2+ binding site [chemical binding]; other site 189518001383 Switch I region; other site 189518001384 G2 box; other site 189518001385 G3 box; other site 189518001386 Switch II region; other site 189518001387 G4 box; other site 189518001388 G5 box; other site 189518001389 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 189518001390 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 189518001391 Antibiotic Binding Site [chemical binding]; other site 189518001392 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 189518001393 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 189518001394 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 189518001395 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 189518001396 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 189518001397 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 189518001398 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 189518001399 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 189518001400 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 189518001401 putative translocon binding site; other site 189518001402 protein-rRNA interface [nucleotide binding]; other site 189518001403 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 189518001404 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 189518001405 G-X-X-G motif; other site 189518001406 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 189518001407 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 189518001408 23S rRNA interface [nucleotide binding]; other site 189518001409 5S rRNA interface [nucleotide binding]; other site 189518001410 putative antibiotic binding site [chemical binding]; other site 189518001411 L25 interface [polypeptide binding]; other site 189518001412 L27 interface [polypeptide binding]; other site 189518001413 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 189518001414 putative translocon interaction site; other site 189518001415 23S rRNA interface [nucleotide binding]; other site 189518001416 signal recognition particle (SRP54) interaction site; other site 189518001417 L23 interface [polypeptide binding]; other site 189518001418 trigger factor interaction site; other site 189518001419 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 189518001420 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 189518001421 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 189518001422 RNA binding site [nucleotide binding]; other site 189518001423 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 189518001424 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 189518001425 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 189518001426 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 189518001427 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 189518001428 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 189518001429 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 189518001430 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 189518001431 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 189518001432 5S rRNA interface [nucleotide binding]; other site 189518001433 L27 interface [polypeptide binding]; other site 189518001434 23S rRNA interface [nucleotide binding]; other site 189518001435 L5 interface [polypeptide binding]; other site 189518001436 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 189518001437 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 189518001438 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 189518001439 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 189518001440 23S rRNA binding site [nucleotide binding]; other site 189518001441 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 189518001442 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 189518001443 SecY translocase; Region: SecY; pfam00344 189518001444 adenylate kinase; Provisional; Region: PRK14528 189518001445 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 189518001446 AMP-binding site [chemical binding]; other site 189518001447 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 189518001448 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 189518001449 rRNA binding site [nucleotide binding]; other site 189518001450 predicted 30S ribosome binding site; other site 189518001451 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 189518001452 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 189518001453 30S ribosomal protein S11; Validated; Region: PRK05309 189518001454 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 189518001455 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 189518001456 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189518001457 RNA binding surface [nucleotide binding]; other site 189518001458 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 189518001459 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 189518001460 alphaNTD - beta interaction site [polypeptide binding]; other site 189518001461 alphaNTD homodimer interface [polypeptide binding]; other site 189518001462 alphaNTD - beta' interaction site [polypeptide binding]; other site 189518001463 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 189518001464 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 189518001465 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518001466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 189518001467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001468 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001469 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001470 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 189518001471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518001472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518001473 homodimer interface [polypeptide binding]; other site 189518001474 catalytic residue [active] 189518001475 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 189518001476 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 189518001477 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 189518001478 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 189518001479 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 189518001480 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 189518001481 putative di-iron ligands [ion binding]; other site 189518001482 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 189518001483 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 189518001484 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 189518001485 TM2 domain; Region: TM2; pfam05154 189518001486 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 189518001487 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 189518001488 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 189518001489 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 189518001490 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 189518001491 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 189518001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518001493 S-adenosylmethionine binding site [chemical binding]; other site 189518001494 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 189518001495 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 189518001496 putative RNA binding site [nucleotide binding]; other site 189518001497 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 189518001498 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 189518001499 dimer interface [polypeptide binding]; other site 189518001500 active site 189518001501 citrylCoA binding site [chemical binding]; other site 189518001502 NADH binding [chemical binding]; other site 189518001503 cationic pore residues; other site 189518001504 oxalacetate/citrate binding site [chemical binding]; other site 189518001505 coenzyme A binding site [chemical binding]; other site 189518001506 catalytic triad [active] 189518001507 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 189518001508 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189518001509 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189518001510 catalytic residue [active] 189518001511 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 189518001512 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518001513 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 189518001514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518001515 Coenzyme A binding pocket [chemical binding]; other site 189518001516 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 189518001517 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 189518001518 TPR repeat; Region: TPR_11; pfam13414 189518001519 TPR repeat; Region: TPR_11; pfam13414 189518001520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001521 binding surface 189518001522 TPR motif; other site 189518001523 TPR repeat; Region: TPR_11; pfam13414 189518001524 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 189518001525 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 189518001526 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 189518001527 TMP-binding site; other site 189518001528 ATP-binding site [chemical binding]; other site 189518001529 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189518001530 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189518001531 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189518001532 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189518001533 protein binding site [polypeptide binding]; other site 189518001534 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 189518001535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518001536 Walker A motif; other site 189518001537 ATP binding site [chemical binding]; other site 189518001538 Walker B motif; other site 189518001539 arginine finger; other site 189518001540 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 189518001541 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048 189518001542 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 189518001543 PIN domain; Region: PIN; pfam01850 189518001544 putative active site [active] 189518001545 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518001546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189518001547 Histidine kinase; Region: HisKA_3; pfam07730 189518001548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518001549 ATP binding site [chemical binding]; other site 189518001550 Mg2+ binding site [ion binding]; other site 189518001551 G-X-G motif; other site 189518001552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518001553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518001554 active site 189518001555 phosphorylation site [posttranslational modification] 189518001556 intermolecular recognition site; other site 189518001557 dimerization interface [polypeptide binding]; other site 189518001558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189518001559 DNA binding residues [nucleotide binding] 189518001560 dimerization interface [polypeptide binding]; other site 189518001561 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 189518001562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518001563 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189518001564 Putative serine esterase (DUF676); Region: DUF676; pfam05057 189518001565 methionine sulfoxide reductase B; Provisional; Region: PRK00222 189518001566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518001567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518001568 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518001569 active site 189518001570 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189518001571 active site 2 [active] 189518001572 active site 1 [active] 189518001573 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189518001574 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 189518001575 dimer interface [polypeptide binding]; other site 189518001576 active site 189518001577 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 189518001578 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 189518001579 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 189518001580 nucleotide binding site [chemical binding]; other site 189518001581 Type III pantothenate kinase; Region: Pan_kinase; cl17198 189518001582 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518001583 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 189518001584 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 189518001585 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 189518001586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189518001587 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189518001588 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518001589 anti sigma factor interaction site; other site 189518001590 regulatory phosphorylation site [posttranslational modification]; other site 189518001591 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 189518001592 active site 189518001593 ribulose/triose binding site [chemical binding]; other site 189518001594 phosphate binding site [ion binding]; other site 189518001595 substrate (anthranilate) binding pocket [chemical binding]; other site 189518001596 product (indole) binding pocket [chemical binding]; other site 189518001597 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14465 189518001598 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 189518001599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518001600 FeS/SAM binding site; other site 189518001601 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 189518001602 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 189518001603 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 189518001604 active site 189518001605 catalytic residues [active] 189518001606 metal binding site [ion binding]; metal-binding site 189518001607 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 189518001608 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 189518001609 dimer interface [polypeptide binding]; other site 189518001610 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 189518001611 dimer interface [polypeptide binding]; other site 189518001612 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 189518001613 hypothetical protein; Provisional; Region: PRK14553 189518001614 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 189518001615 GTPase CgtA; Reviewed; Region: obgE; PRK12299 189518001616 GTP1/OBG; Region: GTP1_OBG; pfam01018 189518001617 Obg GTPase; Region: Obg; cd01898 189518001618 G1 box; other site 189518001619 GTP/Mg2+ binding site [chemical binding]; other site 189518001620 Switch I region; other site 189518001621 G2 box; other site 189518001622 G3 box; other site 189518001623 Switch II region; other site 189518001624 G4 box; other site 189518001625 G5 box; other site 189518001626 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 189518001627 nucleotide binding site [chemical binding]; other site 189518001628 homotetrameric interface [polypeptide binding]; other site 189518001629 putative phosphate binding site [ion binding]; other site 189518001630 putative allosteric binding site; other site 189518001631 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 189518001632 putative catalytic cysteine [active] 189518001633 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 189518001634 active site 189518001635 (T/H)XGH motif; other site 189518001636 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518001637 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518001638 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518001639 anti sigma factor interaction site; other site 189518001640 regulatory phosphorylation site [posttranslational modification]; other site 189518001641 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 189518001642 dimer interface [polypeptide binding]; other site 189518001643 catalytic triad [active] 189518001644 peroxidatic and resolving cysteines [active] 189518001645 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 189518001646 HDOD domain; Region: HDOD; pfam08668 189518001647 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 189518001648 NAD(P) binding site [chemical binding]; other site 189518001649 catalytic residues [active] 189518001650 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 189518001651 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 189518001652 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518001653 Leucine-rich repeats; other site 189518001654 Leucine rich repeat; Region: LRR_8; pfam13855 189518001655 Substrate binding site [chemical binding]; other site 189518001656 Leucine rich repeat; Region: LRR_8; pfam13855 189518001657 Leucine rich repeat; Region: LRR_8; pfam13855 189518001658 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518001659 Leucine-rich repeats; other site 189518001660 Leucine rich repeat; Region: LRR_8; pfam13855 189518001661 Substrate binding site [chemical binding]; other site 189518001662 Leucine rich repeat; Region: LRR_8; pfam13855 189518001663 Leucine rich repeat; Region: LRR_8; pfam13855 189518001664 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189518001665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518001666 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 189518001667 DNA binding residues [nucleotide binding] 189518001668 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 189518001669 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 189518001670 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189518001671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189518001672 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 189518001673 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 189518001674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189518001675 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 189518001676 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 189518001677 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 189518001678 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 189518001679 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 189518001680 SLBB domain; Region: SLBB; pfam10531 189518001681 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 189518001682 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 189518001683 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 189518001684 putative dimer interface [polypeptide binding]; other site 189518001685 [2Fe-2S] cluster binding site [ion binding]; other site 189518001686 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 189518001687 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 189518001688 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 189518001689 NADH dehydrogenase subunit B; Provisional; Region: PRK14814 189518001690 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 189518001691 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 189518001692 putative active site [active] 189518001693 putative catalytic site [active] 189518001694 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189518001695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 189518001696 Methyltransferase domain; Region: Methyltransf_26; pfam13659 189518001697 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 189518001698 heme-binding site [chemical binding]; other site 189518001699 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 189518001700 active site 189518001701 dimer interfaces [polypeptide binding]; other site 189518001702 catalytic residues [active] 189518001703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001704 binding surface 189518001705 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518001706 TPR motif; other site 189518001707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001708 TPR motif; other site 189518001709 binding surface 189518001710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001711 binding surface 189518001712 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189518001713 NHL repeat; Region: NHL; pfam01436 189518001714 NHL repeat; Region: NHL; pfam01436 189518001715 von Willebrand factor type A domain; Region: VWA_2; pfam13519 189518001716 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518001717 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 189518001718 active site 189518001719 Zn binding site [ion binding]; other site 189518001720 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 189518001721 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189518001722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518001723 substrate binding site [chemical binding]; other site 189518001724 oxyanion hole (OAH) forming residues; other site 189518001725 trimer interface [polypeptide binding]; other site 189518001726 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 189518001727 PilZ domain; Region: PilZ; pfam07238 189518001728 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001729 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001730 TPR repeat; Region: TPR_11; pfam13414 189518001731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001732 binding surface 189518001733 TPR motif; other site 189518001734 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 189518001735 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 189518001736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518001737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189518001738 putative substrate translocation pore; other site 189518001739 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 189518001740 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189518001741 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518001742 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 189518001743 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518001744 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 189518001745 putative active site [active] 189518001746 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 189518001747 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 189518001748 putative substrate binding site [chemical binding]; other site 189518001749 putative ATP binding site [chemical binding]; other site 189518001750 hypothetical protein; Provisional; Region: PRK14635 189518001751 heptamer interface [polypeptide binding]; other site 189518001752 Sm1 motif; other site 189518001753 hexamer interface [polypeptide binding]; other site 189518001754 RNA binding site [nucleotide binding]; other site 189518001755 Sm2 motif; other site 189518001756 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 189518001757 NusA N-terminal domain; Region: NusA_N; pfam08529 189518001758 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 189518001759 RNA binding site [nucleotide binding]; other site 189518001760 homodimer interface [polypeptide binding]; other site 189518001761 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 189518001762 G-X-X-G motif; other site 189518001763 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 189518001764 G-X-X-G motif; other site 189518001765 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 189518001766 Proline-rich; Region: Pro-rich; pfam15240 189518001767 Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577 189518001768 translation initiation factor IF-2; Region: IF-2; TIGR00487 189518001769 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 189518001770 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 189518001771 G1 box; other site 189518001772 putative GEF interaction site [polypeptide binding]; other site 189518001773 GTP/Mg2+ binding site [chemical binding]; other site 189518001774 Switch I region; other site 189518001775 G2 box; other site 189518001776 G3 box; other site 189518001777 Switch II region; other site 189518001778 G4 box; other site 189518001779 G5 box; other site 189518001780 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 189518001781 Translation-initiation factor 2; Region: IF-2; pfam11987 189518001782 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 189518001783 Ribosome-binding factor A; Region: RBFA; pfam02033 189518001784 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 189518001785 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 189518001786 active site 189518001787 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 189518001788 16S/18S rRNA binding site [nucleotide binding]; other site 189518001789 S13e-L30e interaction site [polypeptide binding]; other site 189518001790 25S rRNA binding site [nucleotide binding]; other site 189518001791 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 189518001792 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 189518001793 RNase E interface [polypeptide binding]; other site 189518001794 trimer interface [polypeptide binding]; other site 189518001795 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 189518001796 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 189518001797 RNase E interface [polypeptide binding]; other site 189518001798 trimer interface [polypeptide binding]; other site 189518001799 active site 189518001800 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 189518001801 putative nucleic acid binding region [nucleotide binding]; other site 189518001802 G-X-X-G motif; other site 189518001803 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 189518001804 RNA binding site [nucleotide binding]; other site 189518001805 domain interface; other site 189518001806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 189518001807 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 189518001808 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 189518001809 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 189518001810 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 189518001811 active site 189518001812 dimer interface [polypeptide binding]; other site 189518001813 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 189518001814 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189518001815 active site 189518001816 FMN binding site [chemical binding]; other site 189518001817 substrate binding site [chemical binding]; other site 189518001818 3Fe-4S cluster binding site [ion binding]; other site 189518001819 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 189518001820 domain interface; other site 189518001821 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 189518001822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 189518001823 Outer membrane efflux protein; Region: OEP; pfam02321 189518001824 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 189518001825 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 189518001826 catalytic residues [active] 189518001827 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 189518001828 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518001829 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 189518001830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518001831 ATP binding site [chemical binding]; other site 189518001832 putative Mg++ binding site [ion binding]; other site 189518001833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518001834 nucleotide binding region [chemical binding]; other site 189518001835 ATP-binding site [chemical binding]; other site 189518001836 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 189518001837 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 189518001838 Part of AAA domain; Region: AAA_19; pfam13245 189518001839 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 189518001840 AAA domain; Region: AAA_11; pfam13086 189518001841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518001842 ATP binding site [chemical binding]; other site 189518001843 putative Mg++ binding site [ion binding]; other site 189518001844 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 189518001845 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189518001846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518001847 Walker A/P-loop; other site 189518001848 ATP binding site [chemical binding]; other site 189518001849 Q-loop/lid; other site 189518001850 ABC transporter signature motif; other site 189518001851 Walker B; other site 189518001852 D-loop; other site 189518001853 H-loop/switch region; other site 189518001854 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189518001855 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 189518001856 short chain dehydrogenase; Provisional; Region: PRK05872 189518001857 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 189518001858 putative NAD(P) binding site [chemical binding]; other site 189518001859 homotetramer interface [polypeptide binding]; other site 189518001860 active site 189518001861 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 189518001862 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518001863 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518001864 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 189518001865 ThiC family; Region: ThiC; pfam01964 189518001866 WG containing repeat; Region: WG_beta_rep; pfam14903 189518001867 WG containing repeat; Region: WG_beta_rep; pfam14903 189518001868 WG containing repeat; Region: WG_beta_rep; pfam14903 189518001869 WG containing repeat; Region: WG_beta_rep; pfam14903 189518001870 WG containing repeat; Region: WG_beta_rep; pfam14903 189518001871 WG containing repeat; Region: WG_beta_rep; pfam14903 189518001872 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 189518001873 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 189518001874 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cd06846 189518001875 active site 189518001876 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 189518001877 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 189518001878 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518001879 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 189518001880 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 189518001881 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 189518001882 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 189518001883 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 189518001884 Mechanosensitive ion channel; Region: MS_channel; pfam00924 189518001885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518001886 dimerization interface [polypeptide binding]; other site 189518001887 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 189518001888 cyclase homology domain; Region: CHD; cd07302 189518001889 nucleotidyl binding site; other site 189518001890 metal binding site [ion binding]; metal-binding site 189518001891 dimer interface [polypeptide binding]; other site 189518001892 FecR protein; Region: FecR; pfam04773 189518001893 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 189518001894 Interdomain contacts; other site 189518001895 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518001896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518001897 Coenzyme A binding pocket [chemical binding]; other site 189518001898 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 189518001899 oligomeric interface; other site 189518001900 putative active site [active] 189518001901 homodimer interface [polypeptide binding]; other site 189518001902 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 189518001903 Bacterial SH3 domain; Region: SH3_3; pfam08239 189518001904 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 189518001905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518001906 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518001907 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518001908 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 189518001909 catalytic residues [active] 189518001910 dimer interface [polypeptide binding]; other site 189518001911 Protein of unknown function, DUF399; Region: DUF399; pfam04187 189518001912 Transglycosylase; Region: Transgly; pfam00912 189518001913 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 189518001914 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189518001915 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 189518001916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001917 binding surface 189518001918 TPR motif; other site 189518001919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001920 binding surface 189518001921 TPR motif; other site 189518001922 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 189518001923 trimerization site [polypeptide binding]; other site 189518001924 active site 189518001925 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 189518001926 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 189518001927 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 189518001928 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 189518001929 transcription termination factor Rho; Provisional; Region: rho; PRK09376 189518001930 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 189518001931 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 189518001932 RNA binding site [nucleotide binding]; other site 189518001933 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 189518001934 multimer interface [polypeptide binding]; other site 189518001935 Walker A motif; other site 189518001936 ATP binding site [chemical binding]; other site 189518001937 Walker B motif; other site 189518001938 CBS domain; Region: CBS; pfam00571 189518001939 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 189518001940 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 189518001941 Uncharacterized conserved protein [Function unknown]; Region: COG5276 189518001942 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 189518001943 putative catalytic site [active] 189518001944 metal binding site A [ion binding]; metal-binding site 189518001945 phosphate binding site [ion binding]; other site 189518001946 metal binding site C [ion binding]; metal-binding site 189518001947 metal binding site B [ion binding]; metal-binding site 189518001948 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 189518001949 putative catalytic site [active] 189518001950 metal binding site A [ion binding]; metal-binding site 189518001951 phosphate binding site [ion binding]; other site 189518001952 metal binding site C [ion binding]; metal-binding site 189518001953 metal binding site B [ion binding]; metal-binding site 189518001954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001955 binding surface 189518001956 TPR motif; other site 189518001957 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518001958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518001959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518001960 binding surface 189518001961 TPR motif; other site 189518001962 TPR repeat; Region: TPR_11; pfam13414 189518001963 enoyl-CoA hydratase; Provisional; Region: PRK06142 189518001964 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518001965 substrate binding site [chemical binding]; other site 189518001966 oxyanion hole (OAH) forming residues; other site 189518001967 trimer interface [polypeptide binding]; other site 189518001968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518001969 active site 189518001970 phosphorylation site [posttranslational modification] 189518001971 intermolecular recognition site; other site 189518001972 dimerization interface [polypeptide binding]; other site 189518001973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518001974 PAS domain; Region: PAS_9; pfam13426 189518001975 putative active site [active] 189518001976 heme pocket [chemical binding]; other site 189518001977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518001978 Histidine kinase; Region: HisKA_2; pfam07568 189518001979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518001980 ATP binding site [chemical binding]; other site 189518001981 Mg2+ binding site [ion binding]; other site 189518001982 G-X-G motif; other site 189518001983 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 189518001984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518001985 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518001986 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518001987 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518001988 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 189518001989 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 189518001990 Transglycosylase; Region: Transgly; pfam00912 189518001991 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189518001992 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 189518001993 diaminopimelate decarboxylase; Provisional; Region: PRK11165 189518001994 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 189518001995 active site 189518001996 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189518001997 substrate binding site [chemical binding]; other site 189518001998 catalytic residues [active] 189518001999 dimer interface [polypeptide binding]; other site 189518002000 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 189518002001 substrate binding site; other site 189518002002 dimer interface; other site 189518002003 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 189518002004 tail protein; Region: PHA00965; cl19585 189518002005 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 189518002006 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 189518002007 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 189518002008 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 189518002009 Putative pectinesterase/pectinesterase inhibitor; Region: PLN02745 189518002010 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 189518002011 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 189518002012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518002013 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 189518002014 Heme NO binding associated; Region: HNOBA; pfam07701 189518002015 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 189518002016 cyclase homology domain; Region: CHD; cd07302 189518002017 nucleotidyl binding site; other site 189518002018 metal binding site [ion binding]; metal-binding site 189518002019 dimer interface [polypeptide binding]; other site 189518002020 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518002021 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 189518002022 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 189518002023 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 189518002024 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 189518002025 Zn binding site [ion binding]; other site 189518002026 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 189518002027 enterobactin exporter EntS; Provisional; Region: PRK10489 189518002028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518002029 putative substrate translocation pore; other site 189518002030 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 189518002031 dimer interface [polypeptide binding]; other site 189518002032 ADP-ribose binding site [chemical binding]; other site 189518002033 active site 189518002034 nudix motif; other site 189518002035 metal binding site [ion binding]; metal-binding site 189518002036 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 189518002037 Part of AAA domain; Region: AAA_19; pfam13245 189518002038 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 189518002039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518002040 binding surface 189518002041 TPR motif; other site 189518002042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189518002043 dimerization interface [polypeptide binding]; other site 189518002044 putative DNA binding site [nucleotide binding]; other site 189518002045 putative Zn2+ binding site [ion binding]; other site 189518002046 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 189518002047 putative hydrophobic ligand binding site [chemical binding]; other site 189518002048 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 189518002049 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189518002050 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 189518002051 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 189518002052 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 189518002053 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 189518002054 Bacterial SH3 domain homologues; Region: SH3b; smart00287 189518002055 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 189518002056 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 189518002057 Outer membrane efflux protein; Region: OEP; pfam02321 189518002058 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 189518002059 CoA binding domain; Region: CoA_binding; smart00881 189518002060 CoA-ligase; Region: Ligase_CoA; pfam00549 189518002061 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 189518002062 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 189518002063 CoA-ligase; Region: Ligase_CoA; pfam00549 189518002064 DnaJ domain; Region: DnaJ; pfam00226 189518002065 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14332 189518002066 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 189518002067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518002068 FeS/SAM binding site; other site 189518002069 TRAM domain; Region: TRAM; cl01282 189518002070 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 189518002071 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 189518002072 GDP-binding site [chemical binding]; other site 189518002073 ACT binding site; other site 189518002074 IMP binding site; other site 189518002075 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 189518002076 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189518002077 motif 1; other site 189518002078 dimer interface [polypeptide binding]; other site 189518002079 active site 189518002080 motif 2; other site 189518002081 motif 3; other site 189518002082 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189518002083 putative acyl-acceptor binding pocket; other site 189518002084 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 189518002085 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 189518002086 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 189518002087 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 189518002088 [2Fe-2S] cluster binding site [ion binding]; other site 189518002089 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 189518002090 putative alpha subunit interface [polypeptide binding]; other site 189518002091 putative active site [active] 189518002092 putative substrate binding site [chemical binding]; other site 189518002093 Fe binding site [ion binding]; other site 189518002094 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 189518002095 trimer interface [polypeptide binding]; other site 189518002096 active site 189518002097 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518002098 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 189518002099 RNase_H superfamily; Region: RNase_H_2; pfam13482 189518002100 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 189518002101 putative active site [active] 189518002102 catalytic triad [active] 189518002103 putative dimer interface [polypeptide binding]; other site 189518002104 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 189518002105 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 189518002106 ligand binding site [chemical binding]; other site 189518002107 NAD binding site [chemical binding]; other site 189518002108 catalytic site [active] 189518002109 homodimer interface [polypeptide binding]; other site 189518002110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518002111 Radical SAM superfamily; Region: Radical_SAM; pfam04055 189518002112 FeS/SAM binding site; other site 189518002113 A new structural DNA glycosylase; Region: AlkD_like; cl11434 189518002114 active site 189518002115 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518002116 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 189518002117 active site 189518002118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518002119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518002120 S-adenosylmethionine binding site [chemical binding]; other site 189518002121 AAA domain; Region: AAA_33; pfam13671 189518002122 AAA domain; Region: AAA_17; pfam13207 189518002123 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 189518002124 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 189518002125 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 189518002126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518002127 non-specific DNA binding site [nucleotide binding]; other site 189518002128 salt bridge; other site 189518002129 sequence-specific DNA binding site [nucleotide binding]; other site 189518002130 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 189518002131 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 189518002132 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 189518002133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518002134 FeS/SAM binding site; other site 189518002135 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 189518002136 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 189518002137 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 189518002138 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 189518002139 Preprotein translocase subunit; Region: YajC; pfam02699 189518002140 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 189518002141 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 189518002142 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 189518002143 Protein export membrane protein; Region: SecD_SecF; pfam02355 189518002144 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 189518002145 catalytic motif [active] 189518002146 Zn binding site [ion binding]; other site 189518002147 RibD C-terminal domain; Region: RibD_C; cl17279 189518002148 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 189518002149 Lumazine binding domain; Region: Lum_binding; pfam00677 189518002150 Lumazine binding domain; Region: Lum_binding; pfam00677 189518002151 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 189518002152 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 189518002153 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 189518002154 dimerization interface [polypeptide binding]; other site 189518002155 active site 189518002156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189518002157 substrate binding pocket [chemical binding]; other site 189518002158 membrane-bound complex binding site; other site 189518002159 hinge residues; other site 189518002160 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 189518002161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189518002162 dimer interface [polypeptide binding]; other site 189518002163 conserved gate region; other site 189518002164 putative PBP binding loops; other site 189518002165 ABC-ATPase subunit interface; other site 189518002166 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 189518002167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189518002168 dimer interface [polypeptide binding]; other site 189518002169 conserved gate region; other site 189518002170 putative PBP binding loops; other site 189518002171 ABC-ATPase subunit interface; other site 189518002172 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 189518002173 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 189518002174 Walker A/P-loop; other site 189518002175 ATP binding site [chemical binding]; other site 189518002176 Q-loop/lid; other site 189518002177 ABC transporter signature motif; other site 189518002178 Walker B; other site 189518002179 D-loop; other site 189518002180 H-loop/switch region; other site 189518002181 TOBE-like domain; Region: TOBE_3; pfam12857 189518002182 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518002183 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518002184 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 189518002185 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 189518002186 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 189518002187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189518002188 active site 189518002189 ATP binding site [chemical binding]; other site 189518002190 substrate binding site [chemical binding]; other site 189518002191 activation loop (A-loop); other site 189518002192 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189518002193 AAA ATPase domain; Region: AAA_16; pfam13191 189518002194 Predicted ATPase [General function prediction only]; Region: COG3899 189518002195 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189518002196 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 189518002197 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518002198 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 189518002199 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 189518002200 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 189518002201 Peptidase family M48; Region: Peptidase_M48; cl12018 189518002202 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 189518002203 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 189518002204 acyl-activating enzyme (AAE) consensus motif; other site 189518002205 putative AMP binding site [chemical binding]; other site 189518002206 putative active site [active] 189518002207 putative CoA binding site [chemical binding]; other site 189518002208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189518002209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189518002210 substrate binding pocket [chemical binding]; other site 189518002211 membrane-bound complex binding site; other site 189518002212 hinge residues; other site 189518002213 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 189518002214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518002215 ATP binding site [chemical binding]; other site 189518002216 Mg2+ binding site [ion binding]; other site 189518002217 G-X-G motif; other site 189518002218 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 189518002219 ATP binding site [chemical binding]; other site 189518002220 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 189518002221 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 189518002222 Leucine rich repeat; Region: LRR_8; pfam13855 189518002223 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002224 recombination factor protein RarA; Reviewed; Region: PRK13342 189518002225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518002226 Walker A motif; other site 189518002227 ATP binding site [chemical binding]; other site 189518002228 Walker B motif; other site 189518002229 arginine finger; other site 189518002230 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 189518002231 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 189518002232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518002233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518002234 homodimer interface [polypeptide binding]; other site 189518002235 catalytic residue [active] 189518002236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 189518002237 catalytic loop [active] 189518002238 iron binding site [ion binding]; other site 189518002239 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518002240 cyclase homology domain; Region: CHD; cd07302 189518002241 nucleotidyl binding site; other site 189518002242 metal binding site [ion binding]; metal-binding site 189518002243 dimer interface [polypeptide binding]; other site 189518002244 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cd00314 189518002245 heme binding site [chemical binding]; other site 189518002246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002247 active site 189518002248 phosphorylation site [posttranslational modification] 189518002249 intermolecular recognition site; other site 189518002250 dimerization interface [polypeptide binding]; other site 189518002251 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 189518002252 nucleotidyl binding site; other site 189518002253 metal binding site [ion binding]; metal-binding site 189518002254 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518002255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002256 active site 189518002257 phosphorylation site [posttranslational modification] 189518002258 intermolecular recognition site; other site 189518002259 dimerization interface [polypeptide binding]; other site 189518002260 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518002261 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 189518002262 30S subunit binding site; other site 189518002263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518002264 binding surface 189518002265 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518002266 TPR motif; other site 189518002267 Cache domain; Region: Cache_1; pfam02743 189518002268 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189518002269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518002270 dimerization interface [polypeptide binding]; other site 189518002271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518002272 dimer interface [polypeptide binding]; other site 189518002273 putative CheW interface [polypeptide binding]; other site 189518002274 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518002275 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 189518002276 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518002277 substrate binding site [chemical binding]; other site 189518002278 oxyanion hole (OAH) forming residues; other site 189518002279 trimer interface [polypeptide binding]; other site 189518002280 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 189518002281 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 189518002282 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518002283 PilZ domain; Region: PilZ; pfam07238 189518002284 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 189518002285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518002286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518002287 DNA binding residues [nucleotide binding] 189518002288 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518002289 active site 189518002290 Peptidase family C69; Region: Peptidase_C69; cl17793 189518002291 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 189518002292 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 189518002293 putative catalytic residues [active] 189518002294 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 189518002295 Ligand Binding Site [chemical binding]; other site 189518002296 HAMP domain; Region: HAMP; pfam00672 189518002297 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518002298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518002299 dimer interface [polypeptide binding]; other site 189518002300 putative CheW interface [polypeptide binding]; other site 189518002301 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 189518002302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189518002303 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 189518002304 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 189518002305 Transglycosylase; Region: Transgly; pfam00912 189518002306 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 189518002307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189518002308 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 189518002309 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189518002310 E3 interaction surface; other site 189518002311 lipoyl attachment site [posttranslational modification]; other site 189518002312 e3 binding domain; Region: E3_binding; pfam02817 189518002313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 189518002314 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 189518002315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518002316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189518002317 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 189518002318 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 189518002319 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 189518002320 TPP-binding site [chemical binding]; other site 189518002321 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 189518002322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189518002323 HSP90 family protein; Provisional; Region: PRK14083 189518002324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518002325 ATP binding site [chemical binding]; other site 189518002326 Mg2+ binding site [ion binding]; other site 189518002327 G-X-G motif; other site 189518002328 Hsp90 protein; Region: HSP90; pfam00183 189518002329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518002330 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518002331 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518002332 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 189518002333 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 189518002334 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 189518002335 catalytic site [active] 189518002336 subunit interface [polypeptide binding]; other site 189518002337 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 189518002338 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 189518002339 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 189518002340 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 189518002341 active site 189518002342 dimer interface [polypeptide binding]; other site 189518002343 motif 1; other site 189518002344 motif 2; other site 189518002345 motif 3; other site 189518002346 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 189518002347 anticodon binding site; other site 189518002348 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 189518002349 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 189518002350 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 189518002351 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 189518002352 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 189518002353 23S rRNA binding site [nucleotide binding]; other site 189518002354 L21 binding site [polypeptide binding]; other site 189518002355 L13 binding site [polypeptide binding]; other site 189518002356 Protein of unknown function (DUF904); Region: DUF904; pfam06005 189518002357 Cell division protein ZapA; Region: ZapA; pfam05164 189518002358 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 189518002359 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 189518002360 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 189518002361 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 189518002362 putative binding surface; other site 189518002363 active site 189518002364 P2 response regulator binding domain; Region: P2; pfam07194 189518002365 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 189518002366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518002367 ATP binding site [chemical binding]; other site 189518002368 Mg2+ binding site [ion binding]; other site 189518002369 G-X-G motif; other site 189518002370 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 189518002371 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 189518002372 Chemotaxis phosphatase CheX; Region: CheX; cl15816 189518002373 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 189518002374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002375 active site 189518002376 phosphorylation site [posttranslational modification] 189518002377 intermolecular recognition site; other site 189518002378 dimerization interface [polypeptide binding]; other site 189518002379 CheB methylesterase; Region: CheB_methylest; pfam01339 189518002380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002381 active site 189518002382 phosphorylation site [posttranslational modification] 189518002383 intermolecular recognition site; other site 189518002384 dimerization interface [polypeptide binding]; other site 189518002385 ScpA/B protein; Region: ScpA_ScpB; cl00598 189518002386 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 189518002387 Chorismate mutase type II; Region: CM_2; pfam01817 189518002388 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 189518002389 Prephenate dehydratase; Region: PDT; pfam00800 189518002390 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 189518002391 putative L-Phe binding site [chemical binding]; other site 189518002392 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 189518002393 prephenate dehydrogenase; Validated; Region: PRK08507 189518002394 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 189518002395 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 189518002396 hinge; other site 189518002397 active site 189518002398 cytidylate kinase; Provisional; Region: cmk; PRK00023 189518002399 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 189518002400 AAA domain; Region: AAA_17; pfam13207 189518002401 CMP-binding site; other site 189518002402 The sites determining sugar specificity; other site 189518002403 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 189518002404 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518002405 RNA binding site [nucleotide binding]; other site 189518002406 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 189518002407 RNA binding site [nucleotide binding]; other site 189518002408 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518002409 RNA binding site [nucleotide binding]; other site 189518002410 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518002411 RNA binding site [nucleotide binding]; other site 189518002412 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518002413 RNA binding site [nucleotide binding]; other site 189518002414 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 189518002415 RNA binding site [nucleotide binding]; other site 189518002416 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518002417 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 189518002418 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 189518002419 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 189518002420 putative phosphate acyltransferase; Provisional; Region: PRK05331 189518002421 Sulfatase; Region: Sulfatase; pfam00884 189518002422 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 189518002423 Sulfatase; Region: Sulfatase; pfam00884 189518002424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518002425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518002426 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 189518002427 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 189518002428 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 189518002429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 189518002430 FtsX-like permease family; Region: FtsX; pfam02687 189518002431 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 189518002432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189518002433 Walker A/P-loop; other site 189518002434 ATP binding site [chemical binding]; other site 189518002435 Q-loop/lid; other site 189518002436 ABC transporter signature motif; other site 189518002437 Walker B; other site 189518002438 D-loop; other site 189518002439 H-loop/switch region; other site 189518002440 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 189518002441 Uncharacterized conserved protein [Function unknown]; Region: COG4715 189518002442 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 189518002443 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 189518002444 aspartate aminotransferase; Provisional; Region: PRK05764 189518002445 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518002446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518002447 homodimer interface [polypeptide binding]; other site 189518002448 catalytic residue [active] 189518002449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 189518002450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 189518002451 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518002452 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518002453 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518002454 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518002455 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518002456 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 189518002457 SmpB-tmRNA interface; other site 189518002458 GTP-binding protein Der; Reviewed; Region: PRK00093 189518002459 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 189518002460 G1 box; other site 189518002461 GTP/Mg2+ binding site [chemical binding]; other site 189518002462 Switch I region; other site 189518002463 G2 box; other site 189518002464 Switch II region; other site 189518002465 G3 box; other site 189518002466 G4 box; other site 189518002467 G5 box; other site 189518002468 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 189518002469 G1 box; other site 189518002470 GTP/Mg2+ binding site [chemical binding]; other site 189518002471 Switch I region; other site 189518002472 G2 box; other site 189518002473 G3 box; other site 189518002474 Switch II region; other site 189518002475 G4 box; other site 189518002476 G5 box; other site 189518002477 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 189518002478 membrane protein; Provisional; Region: PRK14409 189518002479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 189518002480 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 189518002481 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 189518002482 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 189518002483 Walker A/P-loop; other site 189518002484 ATP binding site [chemical binding]; other site 189518002485 Q-loop/lid; other site 189518002486 Rice tungro bacilliform virus P46 protein; Region: RTBV_P46; pfam06216 189518002487 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 189518002488 ABC transporter signature motif; other site 189518002489 Walker B; other site 189518002490 D-loop; other site 189518002491 H-loop/switch region; other site 189518002492 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518002493 glutamine synthetase, type I; Region: GlnA; TIGR00653 189518002494 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 189518002495 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 189518002496 Sulfite exporter TauE/SafE; Region: TauE; cl19196 189518002497 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 189518002498 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 189518002499 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 189518002500 dimerization interface [polypeptide binding]; other site 189518002501 ATP binding site [chemical binding]; other site 189518002502 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 189518002503 dimerization interface [polypeptide binding]; other site 189518002504 ATP binding site [chemical binding]; other site 189518002505 Leucine rich repeat; Region: LRR_8; pfam13855 189518002506 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 189518002507 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 189518002508 active site 189518002509 HIGH motif; other site 189518002510 KMSKS motif; other site 189518002511 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 189518002512 tRNA binding surface [nucleotide binding]; other site 189518002513 anticodon binding site; other site 189518002514 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 189518002515 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518002516 anti sigma factor interaction site; other site 189518002517 regulatory phosphorylation site [posttranslational modification]; other site 189518002518 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 189518002519 active site 189518002520 catalytic triad [active] 189518002521 dimer interface [polypeptide binding]; other site 189518002522 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518002523 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518002524 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518002525 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518002526 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 189518002527 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189518002528 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 189518002529 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189518002530 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 189518002531 active site 189518002532 ATP binding site [chemical binding]; other site 189518002533 lipoprotein signal peptidase; Provisional; Region: PRK14783 189518002534 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518002535 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518002536 ligand binding site [chemical binding]; other site 189518002537 flexible hinge region; other site 189518002538 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 189518002539 EamA-like transporter family; Region: EamA; pfam00892 189518002540 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 189518002541 EamA-like transporter family; Region: EamA; pfam00892 189518002542 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 189518002543 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 189518002544 putative acyl-acceptor binding pocket; other site 189518002545 PGAP1-like protein; Region: PGAP1; pfam07819 189518002546 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189518002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002548 active site 189518002549 phosphorylation site [posttranslational modification] 189518002550 intermolecular recognition site; other site 189518002551 dimerization interface [polypeptide binding]; other site 189518002552 CHASE3 domain; Region: CHASE3; pfam05227 189518002553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518002554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518002555 dimer interface [polypeptide binding]; other site 189518002556 phosphorylation site [posttranslational modification] 189518002557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518002558 ATP binding site [chemical binding]; other site 189518002559 Mg2+ binding site [ion binding]; other site 189518002560 G-X-G motif; other site 189518002561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518002562 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518002563 S-adenosylmethionine binding site [chemical binding]; other site 189518002564 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 189518002565 putative active site [active] 189518002566 putative metal binding site [ion binding]; other site 189518002567 Leucine rich repeat; Region: LRR_8; pfam13855 189518002568 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002569 Leucine rich repeat; Region: LRR_8; pfam13855 189518002570 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002571 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002572 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 189518002573 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 189518002574 N-terminal plug; other site 189518002575 ligand-binding site [chemical binding]; other site 189518002576 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189518002577 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 189518002578 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518002579 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518002580 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189518002581 hydrophobic ligand binding site; other site 189518002582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518002583 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518002584 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518002585 MepB protein; Region: MepB; pfam08877 189518002586 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 189518002587 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 189518002588 Oligomerization domain; Region: Oligomerization; pfam02410 189518002589 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518002590 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518002591 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 189518002592 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 189518002593 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189518002594 minor groove reading motif; other site 189518002595 helix-hairpin-helix signature motif; other site 189518002596 substrate binding pocket [chemical binding]; other site 189518002597 active site 189518002598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518002599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189518002600 putative substrate translocation pore; other site 189518002601 Pirin-related protein [General function prediction only]; Region: COG1741 189518002602 Pirin; Region: Pirin; pfam02678 189518002603 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 189518002604 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 189518002605 putative active site [active] 189518002606 catalytic site [active] 189518002607 putative metal binding site [ion binding]; other site 189518002608 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 189518002609 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 189518002610 G1 box; other site 189518002611 putative GEF interaction site [polypeptide binding]; other site 189518002612 GTP/Mg2+ binding site [chemical binding]; other site 189518002613 Switch I region; other site 189518002614 G2 box; other site 189518002615 G3 box; other site 189518002616 Switch II region; other site 189518002617 G4 box; other site 189518002618 G5 box; other site 189518002619 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 189518002620 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 189518002621 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 189518002622 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 189518002623 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 189518002624 conserved cys residue [active] 189518002625 glycyl-tRNA synthetase; Provisional; Region: PRK04173 189518002626 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 189518002627 dimer interface [polypeptide binding]; other site 189518002628 motif 1; other site 189518002629 active site 189518002630 motif 2; other site 189518002631 motif 3; other site 189518002632 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 189518002633 anticodon binding site; other site 189518002634 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 189518002635 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 189518002636 Protease prsW family; Region: PrsW-protease; pfam13367 189518002637 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 189518002638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518002639 S-adenosylmethionine binding site [chemical binding]; other site 189518002640 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 189518002641 adenosine kinase; Provisional; Region: PTZ00247 189518002642 substrate binding site [chemical binding]; other site 189518002643 ATP binding site [chemical binding]; other site 189518002644 MMPL family; Region: MMPL; cl14618 189518002645 MMPL family; Region: MMPL; cl14618 189518002646 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 189518002647 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518002648 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518002649 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189518002650 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189518002651 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 189518002652 dimer interface [polypeptide binding]; other site 189518002653 active site 189518002654 glycine-pyridoxal phosphate binding site [chemical binding]; other site 189518002655 folate binding site [chemical binding]; other site 189518002656 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 189518002657 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 189518002658 putative catalytic site [active] 189518002659 putative metal binding site [ion binding]; other site 189518002660 putative phosphate binding site [ion binding]; other site 189518002661 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 189518002662 tetramer interface [polypeptide binding]; other site 189518002663 active site 189518002664 Mg2+/Mn2+ binding site [ion binding]; other site 189518002665 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 189518002666 dimer interface [polypeptide binding]; other site 189518002667 substrate binding site [chemical binding]; other site 189518002668 metal binding site [ion binding]; metal-binding site 189518002669 GAF domain; Region: GAF_2; pfam13185 189518002670 Heme NO binding associated; Region: HNOBA; pfam07701 189518002671 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 189518002672 cyclase homology domain; Region: CHD; cd07302 189518002673 nucleotidyl binding site; other site 189518002674 metal binding site [ion binding]; metal-binding site 189518002675 dimer interface [polypeptide binding]; other site 189518002676 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 189518002677 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 189518002678 Catalytic domain of Protein Kinases; Region: PKc; cd00180 189518002679 active site 189518002680 ATP binding site [chemical binding]; other site 189518002681 substrate binding site [chemical binding]; other site 189518002682 activation loop (A-loop); other site 189518002683 AAA ATPase domain; Region: AAA_16; pfam13191 189518002684 Predicted ATPase [General function prediction only]; Region: COG3899 189518002685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518002686 binding surface 189518002687 TPR motif; other site 189518002688 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189518002689 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518002690 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 189518002691 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 189518002692 dimer interface [polypeptide binding]; other site 189518002693 active site 189518002694 CoA binding pocket [chemical binding]; other site 189518002695 Coenzyme A transferase; Region: CoA_trans; pfam01144 189518002696 Coenzyme A transferase; Region: CoA_trans; cl17247 189518002697 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518002698 active site 189518002699 short chain dehydrogenase; Provisional; Region: PRK06172 189518002700 classical (c) SDRs; Region: SDR_c; cd05233 189518002701 NAD(P) binding site [chemical binding]; other site 189518002702 active site 189518002703 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 189518002704 active site 189518002705 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 189518002706 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 189518002707 active site 189518002708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002709 active site 189518002710 phosphorylation site [posttranslational modification] 189518002711 intermolecular recognition site; other site 189518002712 dimerization interface [polypeptide binding]; other site 189518002713 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518002714 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518002715 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 189518002716 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 189518002717 nucleotide binding site/active site [active] 189518002718 HIT family signature motif; other site 189518002719 catalytic residue [active] 189518002720 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 189518002721 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 189518002722 nucleotide binding site [chemical binding]; other site 189518002723 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189518002724 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 189518002725 Walker A/P-loop; other site 189518002726 ATP binding site [chemical binding]; other site 189518002727 Q-loop/lid; other site 189518002728 ABC transporter signature motif; other site 189518002729 Walker B; other site 189518002730 D-loop; other site 189518002731 H-loop/switch region; other site 189518002732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518002733 binding surface 189518002734 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518002735 TPR motif; other site 189518002736 Restriction endonuclease; Region: Mrr_cat; cl19295 189518002737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518002738 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518002739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518002740 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 189518002741 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 189518002742 Outer membrane efflux protein; Region: OEP; pfam02321 189518002743 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 189518002744 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 189518002745 HlyD family secretion protein; Region: HlyD_3; pfam13437 189518002746 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 189518002747 LexA repressor; Validated; Region: PRK00215 189518002748 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 189518002749 Catalytic site [active] 189518002750 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 189518002751 C-terminal peptidase (prc); Region: prc; TIGR00225 189518002752 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 189518002753 protein binding site [polypeptide binding]; other site 189518002754 Catalytic dyad [active] 189518002755 UGMP family protein; Validated; Region: PRK09604 189518002756 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 189518002757 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 189518002758 hypothetical protein; Reviewed; Region: PRK00024 189518002759 RadC-like JAB domain; Region: RadC; pfam04002 189518002760 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189518002761 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 189518002762 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 189518002763 Walker A/P-loop; other site 189518002764 ATP binding site [chemical binding]; other site 189518002765 Q-loop/lid; other site 189518002766 ABC transporter signature motif; other site 189518002767 Walker B; other site 189518002768 D-loop; other site 189518002769 H-loop/switch region; other site 189518002770 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 189518002771 putative carbohydrate binding site [chemical binding]; other site 189518002772 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 189518002773 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 189518002774 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 189518002775 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 189518002776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518002777 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518002778 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518002779 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 189518002780 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518002781 AIR carboxylase; Region: AIRC; pfam00731 189518002782 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 189518002783 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 189518002784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189518002785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189518002786 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 189518002787 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 189518002788 Ca binding site [ion binding]; other site 189518002789 active site 189518002790 catalytic site [active] 189518002791 TRL-like protein family; Region: TRL; pfam13146 189518002792 TRL-like protein family; Region: TRL; pfam13146 189518002793 TRL-like protein family; Region: TRL; pfam13146 189518002794 TPR repeat; Region: TPR_11; pfam13414 189518002795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518002796 binding surface 189518002797 TPR motif; other site 189518002798 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 189518002799 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 189518002800 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518002801 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 189518002802 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 189518002803 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 189518002804 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 189518002805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189518002806 motif II; other site 189518002807 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 189518002808 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 189518002809 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189518002810 catalytic residue [active] 189518002811 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 189518002812 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 189518002813 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 189518002814 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189518002815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518002816 metal binding site [ion binding]; metal-binding site 189518002817 active site 189518002818 I-site; other site 189518002819 Aspartyl protease; Region: Asp_protease_2; pfam13650 189518002820 inhibitor binding site; inhibition site 189518002821 catalytic motif [active] 189518002822 Catalytic residue [active] 189518002823 Active site flap [active] 189518002824 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 189518002825 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 189518002826 Ligand Binding Site [chemical binding]; other site 189518002827 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 189518002828 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 189518002829 active site 189518002830 substrate binding site [chemical binding]; other site 189518002831 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 189518002832 FMN binding site [chemical binding]; other site 189518002833 putative catalytic residues [active] 189518002834 PilZ domain; Region: PilZ; pfam07238 189518002835 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 189518002836 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189518002837 RNA binding surface [nucleotide binding]; other site 189518002838 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 189518002839 active site 189518002840 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 189518002841 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 189518002842 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 189518002843 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518002844 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518002845 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 189518002846 TIGR04279 methanogen extracellular domain; Region: TIGR04279 189518002847 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518002848 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518002849 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518002850 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518002851 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518002852 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518002853 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518002854 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 189518002855 FG-GAP repeat; Region: FG-GAP; pfam01839 189518002856 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 189518002857 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518002858 Surface antigen; Region: Bac_surface_Ag; pfam01103 189518002859 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189518002860 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518002861 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518002862 Surface antigen; Region: Bac_surface_Ag; pfam01103 189518002863 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518002864 Surface antigen; Region: Bac_surface_Ag; pfam01103 189518002865 L-aspartate oxidase; Provisional; Region: PRK09077 189518002866 L-aspartate oxidase; Provisional; Region: PRK06175 189518002867 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189518002868 Xyloglucan fucosyltransferase; Region: XG_FTase; pfam03254 189518002869 C-terminal peptidase (prc); Region: prc; TIGR00225 189518002870 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 189518002871 protein binding site [polypeptide binding]; other site 189518002872 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 189518002873 Catalytic dyad [active] 189518002874 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 189518002875 active site 189518002876 hydrophilic channel; other site 189518002877 dimerization interface [polypeptide binding]; other site 189518002878 catalytic residues [active] 189518002879 active site lid [active] 189518002880 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 189518002881 AAA domain; Region: AAA_17; cl19128 189518002882 bacterial Hfq-like; Region: Hfq; cd01716 189518002883 hexamer interface [polypeptide binding]; other site 189518002884 Sm1 motif; other site 189518002885 RNA binding site [nucleotide binding]; other site 189518002886 Sm2 motif; other site 189518002887 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 189518002888 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 189518002889 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 189518002890 Substrate binding site; other site 189518002891 Cupin domain; Region: Cupin_2; cl17218 189518002892 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 189518002893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518002894 binding surface 189518002895 TPR motif; other site 189518002896 FOG: CBS domain [General function prediction only]; Region: COG0517 189518002897 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 189518002898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518002899 active site 189518002900 phosphorylation site [posttranslational modification] 189518002901 intermolecular recognition site; other site 189518002902 dimerization interface [polypeptide binding]; other site 189518002903 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 189518002904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518002905 putative active site [active] 189518002906 heme pocket [chemical binding]; other site 189518002907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518002908 dimer interface [polypeptide binding]; other site 189518002909 phosphorylation site [posttranslational modification] 189518002910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518002911 Leucine rich repeat; Region: LRR_8; pfam13855 189518002912 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002913 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002914 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002915 Leucine rich repeat; Region: LRR_8; pfam13855 189518002916 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518002917 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 189518002918 putative active site; other site 189518002919 catalytic residue [active] 189518002920 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 189518002921 Thymidylate synthase complementing protein; Region: Thy1; cl03630 189518002922 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 189518002923 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 189518002924 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 189518002925 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189518002926 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 189518002927 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 189518002928 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 189518002929 MMPL family; Region: MMPL; cl14618 189518002930 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 189518002931 DNA methylase; Region: N6_N4_Mtase; pfam01555 189518002932 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 189518002933 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 189518002934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189518002935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518002936 Histidine kinase; Region: HisKA_2; pfam07568 189518002937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518002938 ATP binding site [chemical binding]; other site 189518002939 Mg2+ binding site [ion binding]; other site 189518002940 G-X-G motif; other site 189518002941 Cupredoxin superfamily; Region: Cupredoxin; cl19115 189518002942 Right handed beta helix region; Region: Beta_helix; pfam13229 189518002943 Right handed beta helix region; Region: Beta_helix; pfam13229 189518002944 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 189518002945 The cupredoxin domain 1 of a two-domain laccase related to nitrite reductase; Region: CuRO_1_2DMCO_NIR_like; cd11024 189518002946 Domain 2 interface [polypeptide binding]; other site 189518002947 Type 1 (T1) Cu binding site [ion binding]; other site 189518002948 trimer interface [polypeptide binding]; other site 189518002949 trinuclear Cu binding site [ion binding]; other site 189518002950 Cupredoxin superfamily; Region: Cupredoxin; cl19115 189518002951 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 189518002952 Cu(I) binding site [ion binding]; other site 189518002953 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 189518002954 Protein of unknown function, DUF486; Region: DUF486; cl01236 189518002955 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 189518002956 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 189518002957 putative dimer interface [polypeptide binding]; other site 189518002958 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 189518002959 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 189518002960 putative dimer interface [polypeptide binding]; other site 189518002961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518002962 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518002963 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518002964 potential frameshift: common BLAST hit: gi|45658058|ref|YP_002144.1| lipoprotein 189518002965 Beta-propeller repeat; Region: SBBP; pfam06739 189518002966 Beta-propeller repeat; Region: SBBP; pfam06739 189518002967 Beta-propeller repeat; Region: SBBP; pfam06739 189518002968 Beta-propeller repeat; Region: SBBP; pfam06739 189518002969 Beta-propeller repeat; Region: SBBP; pfam06739 189518002970 Beta-propeller repeat; Region: SBBP; pfam06739 189518002971 Beta-propeller repeat; Region: SBBP; pfam06739 189518002972 Beta-propeller repeat; Region: SBBP; pfam06739 189518002973 Beta-propeller repeat; Region: SBBP; pfam06739 189518002974 Beta-propeller repeat; Region: SBBP; pfam06739 189518002975 Beta-propeller repeat; Region: SBBP; pfam06739 189518002976 Beta-propeller repeat; Region: SBBP; pfam06739 189518002977 Beta-propeller repeat; Region: SBBP; pfam06739 189518002978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 189518002979 putative DNA binding site [nucleotide binding]; other site 189518002980 putative Zn2+ binding site [ion binding]; other site 189518002981 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 189518002982 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 189518002983 NADP binding site [chemical binding]; other site 189518002984 active site 189518002985 putative substrate binding site [chemical binding]; other site 189518002986 FAD dependent oxidoreductase; Region: DAO; pfam01266 189518002987 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 189518002988 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 189518002989 dimer interface [polypeptide binding]; other site 189518002990 active site 189518002991 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189518002992 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 189518002993 NAD binding site [chemical binding]; other site 189518002994 substrate binding site [chemical binding]; other site 189518002995 homodimer interface [polypeptide binding]; other site 189518002996 active site 189518002997 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 189518002998 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 189518002999 active site 189518003000 Substrate binding site; other site 189518003001 Mg++ binding site; other site 189518003002 cytidylyltransferase; Region: cytidylyltransferase; cd02170 189518003003 active site 189518003004 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 189518003005 putative ribose interaction site [chemical binding]; other site 189518003006 putative ADP binding site [chemical binding]; other site 189518003007 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189518003008 extended (e) SDRs; Region: SDR_e; cd08946 189518003009 NAD(P) binding site [chemical binding]; other site 189518003010 active site 189518003011 substrate binding site [chemical binding]; other site 189518003012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518003013 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 189518003014 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 189518003015 TPP-binding site [chemical binding]; other site 189518003016 dimer interface [polypeptide binding]; other site 189518003017 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 189518003018 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 189518003019 PYR/PP interface [polypeptide binding]; other site 189518003020 dimer interface [polypeptide binding]; other site 189518003021 TPP binding site [chemical binding]; other site 189518003022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189518003023 sporadic carbohydrate cluster 2OG-Fe(II) oxygenase; Region: SpoChoClust_2; TIGR04324 189518003024 sporadic carbohydrate cluster protein, LIC12192 family; Region: SpoChoClust_1; TIGR04323 189518003025 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 189518003026 nudix motif; other site 189518003027 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518003028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003029 S-adenosylmethionine binding site [chemical binding]; other site 189518003030 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 189518003031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003032 S-adenosylmethionine binding site [chemical binding]; other site 189518003033 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 189518003034 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 189518003035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003036 S-adenosylmethionine binding site [chemical binding]; other site 189518003037 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 189518003038 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 189518003039 inhibitor-cofactor binding pocket; inhibition site 189518003040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518003041 catalytic residue [active] 189518003042 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 189518003043 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 189518003044 active site 189518003045 substrate binding site [chemical binding]; other site 189518003046 cosubstrate binding site; other site 189518003047 catalytic site [active] 189518003048 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 189518003049 catalytic site [active] 189518003050 Transposase DNA-binding; Region: Tnp_DNA_bind; pfam14706 189518003051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518003052 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 189518003053 putative trimer interface [polypeptide binding]; other site 189518003054 putative CoA binding site [chemical binding]; other site 189518003055 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189518003056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189518003057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518003058 Walker A/P-loop; other site 189518003059 ATP binding site [chemical binding]; other site 189518003060 Q-loop/lid; other site 189518003061 ABC transporter signature motif; other site 189518003062 Walker B; other site 189518003063 D-loop; other site 189518003064 H-loop/switch region; other site 189518003065 WxcM-like, C-terminal; Region: FdtA; pfam05523 189518003066 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518003067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003068 S-adenosylmethionine binding site [chemical binding]; other site 189518003069 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 189518003070 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 189518003071 Ligand binding site; other site 189518003072 Putative Catalytic site; other site 189518003073 DXD motif; other site 189518003074 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 189518003075 ligand binding site; other site 189518003076 tetramer interface; other site 189518003077 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 189518003078 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 189518003079 NAD binding site [chemical binding]; other site 189518003080 substrate binding site [chemical binding]; other site 189518003081 active site 189518003082 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 189518003083 inhibitor-cofactor binding pocket; inhibition site 189518003084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518003085 catalytic residue [active] 189518003086 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 189518003087 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 189518003088 putative trimer interface [polypeptide binding]; other site 189518003089 putative CoA binding site [chemical binding]; other site 189518003090 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 189518003091 NeuB family; Region: NeuB; pfam03102 189518003092 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 189518003093 NeuB binding interface [polypeptide binding]; other site 189518003094 putative substrate binding site [chemical binding]; other site 189518003095 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 189518003096 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 189518003097 active site 189518003098 homodimer interface [polypeptide binding]; other site 189518003099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 189518003100 FOG: CBS domain [General function prediction only]; Region: COG0517 189518003101 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 189518003102 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 189518003103 Substrate binding site; other site 189518003104 metal-binding site 189518003105 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 189518003106 FOG: CBS domain [General function prediction only]; Region: COG0517 189518003107 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 189518003108 NeuB family; Region: NeuB; pfam03102 189518003109 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 189518003110 NeuB binding interface [polypeptide binding]; other site 189518003111 putative substrate binding site [chemical binding]; other site 189518003112 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 189518003113 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 189518003114 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 189518003115 inhibitor-cofactor binding pocket; inhibition site 189518003116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518003117 catalytic residue [active] 189518003118 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 189518003119 ligand binding site; other site 189518003120 tetramer interface; other site 189518003121 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH3; cd08184 189518003122 putative active site [active] 189518003123 metal binding site [ion binding]; metal-binding site 189518003124 Radical SAM superfamily; Region: Radical_SAM; pfam04055 189518003125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518003126 FeS/SAM binding site; other site 189518003127 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 189518003128 Methyltransferase domain; Region: Methyltransf_23; pfam13489 189518003129 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 189518003130 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 189518003131 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 189518003132 putative active site [active] 189518003133 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 189518003134 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 189518003135 trimer interface [polypeptide binding]; other site 189518003136 active site 189518003137 substrate binding site [chemical binding]; other site 189518003138 CoA binding site [chemical binding]; other site 189518003139 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 189518003140 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 189518003141 Ligand binding site; other site 189518003142 oligomer interface; other site 189518003143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189518003144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189518003145 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189518003146 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 189518003147 active site 189518003148 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 189518003149 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 189518003150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003151 S-adenosylmethionine binding site [chemical binding]; other site 189518003152 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 189518003153 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 189518003154 putative ligand binding site [chemical binding]; other site 189518003155 putative NAD binding site [chemical binding]; other site 189518003156 catalytic site [active] 189518003157 surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326 189518003158 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 189518003159 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 189518003160 substrate binding site; other site 189518003161 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 189518003162 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 189518003163 NAD binding site [chemical binding]; other site 189518003164 homotetramer interface [polypeptide binding]; other site 189518003165 homodimer interface [polypeptide binding]; other site 189518003166 substrate binding site [chemical binding]; other site 189518003167 active site 189518003168 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 189518003169 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189518003170 extended (e) SDRs; Region: SDR_e; cd08946 189518003171 NAD(P) binding site [chemical binding]; other site 189518003172 active site 189518003173 substrate binding site [chemical binding]; other site 189518003174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518003175 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 189518003176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518003177 active site 189518003178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518003179 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 189518003180 putative active site [active] 189518003181 putative metal binding site [ion binding]; other site 189518003182 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 189518003183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518003184 catalytic residue [active] 189518003185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 189518003186 Protein of unknown function (DUF1420); Region: DUF1420; pfam07220 189518003187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518003188 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 189518003189 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 189518003190 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 189518003191 NAD(P) binding site [chemical binding]; other site 189518003192 homodimer interface [polypeptide binding]; other site 189518003193 substrate binding site [chemical binding]; other site 189518003194 active site 189518003195 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 189518003196 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 189518003197 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189518003198 putative NAD(P) binding site [chemical binding]; other site 189518003199 active site 189518003200 putative substrate binding site [chemical binding]; other site 189518003201 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 189518003202 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 189518003203 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 189518003204 active site 189518003205 homodimer interface [polypeptide binding]; other site 189518003206 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518003207 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 189518003208 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 189518003209 Bacterial sugar transferase; Region: Bac_transf; pfam02397 189518003210 Protein of unknown function (DUF1229); Region: DUF1229; pfam06797 189518003211 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 189518003212 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 189518003213 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518003214 active site 189518003215 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 189518003216 WxcM-like, C-terminal; Region: FdtA; pfam05523 189518003217 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 189518003218 inhibitor-cofactor binding pocket; inhibition site 189518003219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518003220 catalytic residue [active] 189518003221 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 189518003222 metal-binding site 189518003223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518003224 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 189518003225 active site 189518003226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 189518003227 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 189518003228 Probable Catalytic site; other site 189518003229 metal-binding site 189518003230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518003231 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 189518003232 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 189518003233 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 189518003234 NADP binding site [chemical binding]; other site 189518003235 active site 189518003236 putative substrate binding site [chemical binding]; other site 189518003237 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 189518003238 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 189518003239 NAD binding site [chemical binding]; other site 189518003240 substrate binding site [chemical binding]; other site 189518003241 homodimer interface [polypeptide binding]; other site 189518003242 active site 189518003243 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 189518003244 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 189518003245 substrate binding site; other site 189518003246 tetramer interface; other site 189518003247 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 189518003248 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 189518003249 Probable Catalytic site; other site 189518003250 metal-binding site 189518003251 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 189518003252 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 189518003253 Ligand binding site; other site 189518003254 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 189518003255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518003256 active site 189518003257 anion transporter; Region: dass; TIGR00785 189518003258 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 189518003259 transmembrane helices; other site 189518003260 HicB family; Region: HicB; pfam05534 189518003261 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 189518003262 putative active site [active] 189518003263 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518003264 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518003265 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518003266 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518003267 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 189518003268 putative active site [active] 189518003269 putative metal binding site [ion binding]; other site 189518003270 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 189518003271 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 189518003272 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 189518003273 dimer interface [polypeptide binding]; other site 189518003274 ssDNA binding site [nucleotide binding]; other site 189518003275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 189518003276 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 189518003277 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 189518003278 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 189518003279 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 189518003280 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 189518003281 replicative DNA helicase; Region: DnaB; TIGR00665 189518003282 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 189518003283 Walker A motif; other site 189518003284 ATP binding site [chemical binding]; other site 189518003285 Walker B motif; other site 189518003286 DNA binding loops [nucleotide binding] 189518003287 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 189518003288 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 189518003289 dimer interface [polypeptide binding]; other site 189518003290 anticodon binding site; other site 189518003291 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 189518003292 homodimer interface [polypeptide binding]; other site 189518003293 motif 1; other site 189518003294 active site 189518003295 motif 2; other site 189518003296 GAD domain; Region: GAD; pfam02938 189518003297 motif 3; other site 189518003298 PhoH-like protein; Region: PhoH; pfam02562 189518003299 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 189518003300 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 189518003301 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 189518003302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518003303 Zn2+ binding site [ion binding]; other site 189518003304 Mg2+ binding site [ion binding]; other site 189518003305 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 189518003306 Recombination protein O N terminal; Region: RecO_N; pfam11967 189518003307 DNA repair protein RecO; Region: reco; TIGR00613 189518003308 Recombination protein O C terminal; Region: RecO_C; pfam02565 189518003309 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 189518003310 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 189518003311 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 189518003312 active site 189518003313 HIGH motif; other site 189518003314 KMSK motif region; other site 189518003315 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 189518003316 tRNA binding surface [nucleotide binding]; other site 189518003317 anticodon binding site; other site 189518003318 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 189518003319 competence damage-inducible protein A; Provisional; Region: PRK00549 189518003320 putative MPT binding site; other site 189518003321 Competence-damaged protein; Region: CinA; pfam02464 189518003322 Beta-propeller repeat; Region: SBBP; pfam06739 189518003323 Beta-propeller repeat; Region: SBBP; pfam06739 189518003324 Beta-propeller repeat; Region: SBBP; pfam06739 189518003325 Beta-propeller repeat; Region: SBBP; pfam06739 189518003326 Beta-propeller repeat; Region: SBBP; pfam06739 189518003327 Beta-propeller repeat; Region: SBBP; pfam06739 189518003328 Beta-propeller repeat; Region: SBBP; pfam06739 189518003329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518003330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003331 active site 189518003332 phosphorylation site [posttranslational modification] 189518003333 intermolecular recognition site; other site 189518003334 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 189518003335 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 189518003336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518003337 dimer interface [polypeptide binding]; other site 189518003338 phosphorylation site [posttranslational modification] 189518003339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518003340 ATP binding site [chemical binding]; other site 189518003341 Mg2+ binding site [ion binding]; other site 189518003342 G-X-G motif; other site 189518003343 protein translocase, SecG subunit; Region: secG; TIGR00810 189518003344 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 189518003345 substrate binding site [chemical binding]; other site 189518003346 dimer interface [polypeptide binding]; other site 189518003347 catalytic triad [active] 189518003348 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518003349 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189518003350 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 189518003351 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 189518003352 substrate binding site [chemical binding]; other site 189518003353 hinge regions; other site 189518003354 ADP binding site [chemical binding]; other site 189518003355 catalytic site [active] 189518003356 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 189518003357 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 189518003358 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 189518003359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518003360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003361 active site 189518003362 phosphorylation site [posttranslational modification] 189518003363 intermolecular recognition site; other site 189518003364 dimerization interface [polypeptide binding]; other site 189518003365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518003366 dimer interface [polypeptide binding]; other site 189518003367 phosphorylation site [posttranslational modification] 189518003368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518003369 ATP binding site [chemical binding]; other site 189518003370 Mg2+ binding site [ion binding]; other site 189518003371 G-X-G motif; other site 189518003372 PAS domain S-box; Region: sensory_box; TIGR00229 189518003373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518003374 putative active site [active] 189518003375 heme pocket [chemical binding]; other site 189518003376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518003377 putative active site [active] 189518003378 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 189518003379 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 189518003380 Catalytic site [active] 189518003381 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 189518003382 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 189518003383 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 189518003384 trimer interface [polypeptide binding]; other site 189518003385 putative metal binding site [ion binding]; other site 189518003386 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 189518003387 cysteine synthase; Region: PLN02565 189518003388 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 189518003389 dimer interface [polypeptide binding]; other site 189518003390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518003391 catalytic residue [active] 189518003392 DNA topoisomerase I; Validated; Region: PRK05582 189518003393 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 189518003394 active site 189518003395 interdomain interaction site; other site 189518003396 putative metal-binding site [ion binding]; other site 189518003397 nucleotide binding site [chemical binding]; other site 189518003398 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 189518003399 domain I; other site 189518003400 DNA binding groove [nucleotide binding] 189518003401 phosphate binding site [ion binding]; other site 189518003402 domain II; other site 189518003403 domain III; other site 189518003404 nucleotide binding site [chemical binding]; other site 189518003405 catalytic site [active] 189518003406 domain IV; other site 189518003407 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 189518003408 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 189518003409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518003410 Walker A/P-loop; other site 189518003411 ATP binding site [chemical binding]; other site 189518003412 Q-loop/lid; other site 189518003413 ABC transporter signature motif; other site 189518003414 Walker B; other site 189518003415 D-loop; other site 189518003416 H-loop/switch region; other site 189518003417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518003418 Zn2+ binding site [ion binding]; other site 189518003419 Mg2+ binding site [ion binding]; other site 189518003420 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 189518003421 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 189518003422 tetramerization interface [polypeptide binding]; other site 189518003423 active site 189518003424 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 189518003425 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 189518003426 Nucleoporin Nup153-like; Region: Nup153; pfam08604 189518003427 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518003428 anti sigma factor interaction site; other site 189518003429 regulatory phosphorylation site [posttranslational modification]; other site 189518003430 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 189518003431 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 189518003432 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 189518003433 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189518003434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 189518003435 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 189518003436 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 189518003437 active site 189518003438 nucleophile elbow; other site 189518003439 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189518003440 putative acyl-acceptor binding pocket; other site 189518003441 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 189518003442 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 189518003443 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 189518003444 CheB methylesterase; Region: CheB_methylest; pfam01339 189518003445 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 189518003446 HAMP domain; Region: HAMP; pfam00672 189518003447 GAF domain; Region: GAF_2; pfam13185 189518003448 Uncharacterized protein KIAA1328; Region: KIAA1328; pfam15369 189518003449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518003450 dimer interface [polypeptide binding]; other site 189518003451 phosphorylation site [posttranslational modification] 189518003452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518003453 ATP binding site [chemical binding]; other site 189518003454 Mg2+ binding site [ion binding]; other site 189518003455 G-X-G motif; other site 189518003456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003457 active site 189518003458 phosphorylation site [posttranslational modification] 189518003459 intermolecular recognition site; other site 189518003460 dimerization interface [polypeptide binding]; other site 189518003461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003462 active site 189518003463 phosphorylation site [posttranslational modification] 189518003464 intermolecular recognition site; other site 189518003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003466 active site 189518003467 phosphorylation site [posttranslational modification] 189518003468 intermolecular recognition site; other site 189518003469 dimerization interface [polypeptide binding]; other site 189518003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003471 active site 189518003472 phosphorylation site [posttranslational modification] 189518003473 intermolecular recognition site; other site 189518003474 dimerization interface [polypeptide binding]; other site 189518003475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518003476 dimer interface [polypeptide binding]; other site 189518003477 phosphorylation site [posttranslational modification] 189518003478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518003479 ATP binding site [chemical binding]; other site 189518003480 Mg2+ binding site [ion binding]; other site 189518003481 G-X-G motif; other site 189518003482 putative transposase OrfB; Reviewed; Region: PHA02517 189518003483 Integrase core domain; Region: rve; pfam00665 189518003484 Integrase core domain; Region: rve_3; cl15866 189518003485 putative transposase OrfB; Reviewed; Region: PHA02517 189518003486 Integrase core domain; Region: rve; pfam00665 189518003487 Integrase core domain; Region: rve_3; pfam13683 189518003488 Transcription termination factor [Transcription]; Region: Rho; COG1158 189518003489 potential frameshift: common BLAST hit: gi|27365775|ref|NP_761303.1| DNA replication ATPase 189518003490 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 189518003491 potential frameshift: common BLAST hit: gi|27365775|ref|NP_761303.1| DNA replication ATPase 189518003492 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 189518003493 epithiospecifier protein; Region: PLN02153 189518003494 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189518003495 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 189518003496 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518003497 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 189518003498 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 189518003499 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 189518003500 RHS Repeat; Region: RHS_repeat; pfam05593 189518003501 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 189518003502 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 189518003503 Integrase core domain; Region: rve; pfam00665 189518003504 Integrase core domain; Region: rve_3; pfam13683 189518003505 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 189518003506 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518003507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189518003508 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 189518003509 PemK-like protein; Region: PemK; cl00995 189518003510 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 189518003511 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 189518003512 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 189518003513 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 189518003514 PIN domain; Region: PIN; pfam01850 189518003515 putative active site [active] 189518003516 Protein of unknown function DUF86; Region: DUF86; cl01031 189518003517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518003518 Coenzyme A binding pocket [chemical binding]; other site 189518003519 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 189518003520 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 189518003521 putative transposase OrfB; Reviewed; Region: PHA02517 189518003522 Integrase core domain; Region: rve; pfam00665 189518003523 Integrase core domain; Region: rve_3; pfam13683 189518003524 L-ascorbate oxidase; Region: PLN02191 189518003525 ribbon-helix-helix domain containing protein; Region: PHA00617 189518003526 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 189518003527 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518003528 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518003529 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 189518003530 putative trimer interface [polypeptide binding]; other site 189518003531 putative CoA binding site [chemical binding]; other site 189518003532 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 189518003533 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 189518003534 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 189518003535 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 189518003536 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 189518003537 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 189518003538 Helix-turn-helix domain; Region: HTH_36; pfam13730 189518003539 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189518003540 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 189518003541 P-loop; other site 189518003542 Magnesium ion binding site [ion binding]; other site 189518003543 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 189518003544 ParB-like nuclease domain; Region: ParB; smart00470 189518003545 Helix-turn-helix domain; Region: HTH_36; pfam13730 189518003546 Transcription termination factor [Transcription]; Region: Rho; COG1158 189518003547 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 189518003548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 189518003549 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 189518003550 dimer interface [polypeptide binding]; other site 189518003551 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 189518003552 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 189518003553 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 189518003554 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 189518003555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 189518003556 metal binding site 2 [ion binding]; metal-binding site 189518003557 putative DNA binding helix; other site 189518003558 metal binding site 1 [ion binding]; metal-binding site 189518003559 dimer interface [polypeptide binding]; other site 189518003560 structural Zn2+ binding site [ion binding]; other site 189518003561 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518003562 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518003563 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 189518003564 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 189518003565 tetramer interface [polypeptide binding]; other site 189518003566 heme binding pocket [chemical binding]; other site 189518003567 NADPH binding site [chemical binding]; other site 189518003568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518003569 PAS fold; Region: PAS_3; pfam08447 189518003570 putative active site [active] 189518003571 heme pocket [chemical binding]; other site 189518003572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518003573 PAS fold; Region: PAS_3; pfam08447 189518003574 putative active site [active] 189518003575 heme pocket [chemical binding]; other site 189518003576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518003577 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518003578 putative active site [active] 189518003579 heme pocket [chemical binding]; other site 189518003580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518003581 putative active site [active] 189518003582 heme pocket [chemical binding]; other site 189518003583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518003584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518003585 ATP binding site [chemical binding]; other site 189518003586 Mg2+ binding site [ion binding]; other site 189518003587 G-X-G motif; other site 189518003588 PGAP1-like protein; Region: PGAP1; pfam07819 189518003589 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 189518003590 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 189518003591 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 189518003592 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 189518003593 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 189518003594 active site 189518003595 HIGH motif; other site 189518003596 KMSKS motif; other site 189518003597 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 189518003598 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 189518003599 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 189518003600 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14177 189518003601 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 189518003602 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 189518003603 homodimer interface [polypeptide binding]; other site 189518003604 NADP binding site [chemical binding]; other site 189518003605 substrate binding site [chemical binding]; other site 189518003606 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 189518003607 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 189518003608 putative dimer interface [polypeptide binding]; other site 189518003609 putative anticodon binding site; other site 189518003610 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 189518003611 homodimer interface [polypeptide binding]; other site 189518003612 motif 1; other site 189518003613 motif 2; other site 189518003614 active site 189518003615 motif 3; other site 189518003616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518003617 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518003618 TPR motif; other site 189518003619 binding surface 189518003620 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 189518003621 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518003622 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 189518003623 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 189518003624 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 189518003625 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 189518003626 Na2 binding site [ion binding]; other site 189518003627 substrate binding site 1 [chemical binding]; other site 189518003628 Na binding site 1 [ion binding]; other site 189518003629 substrate binding site 2 [chemical binding]; other site 189518003630 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 189518003631 Clp amino terminal domain; Region: Clp_N; pfam02861 189518003632 Clp amino terminal domain; Region: Clp_N; pfam02861 189518003633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518003634 Walker A motif; other site 189518003635 ATP binding site [chemical binding]; other site 189518003636 Walker B motif; other site 189518003637 arginine finger; other site 189518003638 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 189518003639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518003640 Walker A motif; other site 189518003641 ATP binding site [chemical binding]; other site 189518003642 Walker B motif; other site 189518003643 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 189518003644 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189518003645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518003646 salt bridge; other site 189518003647 non-specific DNA binding site [nucleotide binding]; other site 189518003648 sequence-specific DNA binding site [nucleotide binding]; other site 189518003649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518003650 non-specific DNA binding site [nucleotide binding]; other site 189518003651 salt bridge; other site 189518003652 sequence-specific DNA binding site [nucleotide binding]; other site 189518003653 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518003654 anti sigma factor interaction site; other site 189518003655 regulatory phosphorylation site [posttranslational modification]; other site 189518003656 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 189518003657 GTP-binding protein LepA; Provisional; Region: PRK05433 189518003658 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 189518003659 G1 box; other site 189518003660 putative GEF interaction site [polypeptide binding]; other site 189518003661 GTP/Mg2+ binding site [chemical binding]; other site 189518003662 Switch I region; other site 189518003663 G2 box; other site 189518003664 G3 box; other site 189518003665 Switch II region; other site 189518003666 G4 box; other site 189518003667 G5 box; other site 189518003668 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 189518003669 Elongation Factor G, domain II; Region: EFG_II; pfam14492 189518003670 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 189518003671 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 189518003672 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 189518003673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518003674 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 189518003675 putative trimer interface [polypeptide binding]; other site 189518003676 putative CoA binding site [chemical binding]; other site 189518003677 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 189518003678 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 189518003679 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 189518003680 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 189518003681 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 189518003682 L-aspartate oxidase; Provisional; Region: PRK06175 189518003683 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 189518003684 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 189518003685 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 189518003686 putative Iron-sulfur protein interface [polypeptide binding]; other site 189518003687 proximal heme binding site [chemical binding]; other site 189518003688 distal heme binding site [chemical binding]; other site 189518003689 putative dimer interface [polypeptide binding]; other site 189518003690 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189518003691 active site 189518003692 catalytic tetrad [active] 189518003693 Domain of unknown function (DUF309); Region: DUF309; pfam03745 189518003694 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189518003695 CoenzymeA binding site [chemical binding]; other site 189518003696 subunit interaction site [polypeptide binding]; other site 189518003697 PHB binding site; other site 189518003698 PilZ domain; Region: PilZ; cl01260 189518003699 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 189518003700 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 189518003701 ligand binding site [chemical binding]; other site 189518003702 NAD binding site [chemical binding]; other site 189518003703 tetramer interface [polypeptide binding]; other site 189518003704 catalytic site [active] 189518003705 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 189518003706 L-serine binding site [chemical binding]; other site 189518003707 ACT domain interface; other site 189518003708 Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string...; Region: H4; cl00074 189518003709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518003710 binding surface 189518003711 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518003712 TPR motif; other site 189518003713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518003714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518003715 binding surface 189518003716 TPR motif; other site 189518003717 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 189518003718 glycogen binding site [chemical binding]; other site 189518003719 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 189518003720 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518003721 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 189518003722 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 189518003723 MORN repeat; Region: MORN; cl14787 189518003724 HAMP domain; Region: HAMP; pfam00672 189518003725 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 189518003726 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 189518003727 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 189518003728 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 189518003729 catalytic residues [active] 189518003730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189518003731 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518003732 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518003733 ligand binding site [chemical binding]; other site 189518003734 flexible hinge region; other site 189518003735 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518003736 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518003737 ligand binding site [chemical binding]; other site 189518003738 flexible hinge region; other site 189518003739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518003740 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518003741 active site 189518003742 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 189518003743 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 189518003744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518003745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189518003746 putative substrate translocation pore; other site 189518003747 major vault protein; Provisional; Region: PTZ00491 189518003748 Bifunctional nuclease; Region: DNase-RNase; pfam02577 189518003749 UvrB/uvrC motif; Region: UVR; pfam02151 189518003750 PGAP1-like protein; Region: PGAP1; pfam07819 189518003751 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 189518003752 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518003753 Transposase; Region: HTH_Tnp_1; cl17663 189518003754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 189518003755 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 189518003756 HEAT repeats; Region: HEAT_2; pfam13646 189518003757 HEAT repeats; Region: HEAT_2; pfam13646 189518003758 HEAT repeats; Region: HEAT_2; pfam13646 189518003759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003760 active site 189518003761 phosphorylation site [posttranslational modification] 189518003762 intermolecular recognition site; other site 189518003763 dimerization interface [polypeptide binding]; other site 189518003764 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 189518003765 enolase; Provisional; Region: eno; PRK00077 189518003766 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 189518003767 dimer interface [polypeptide binding]; other site 189518003768 metal binding site [ion binding]; metal-binding site 189518003769 substrate binding pocket [chemical binding]; other site 189518003770 Septum formation initiator; Region: DivIC; pfam04977 189518003771 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 189518003772 oligomer interface [polypeptide binding]; other site 189518003773 active site residues [active] 189518003774 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 189518003775 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518003776 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 189518003777 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 189518003778 catalytic residues [active] 189518003779 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 189518003780 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 189518003781 catalytic triad [active] 189518003782 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 189518003783 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 189518003784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518003785 nucleotide binding region [chemical binding]; other site 189518003786 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 189518003787 Outer membrane efflux protein; Region: OEP; pfam02321 189518003788 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 189518003789 Outer membrane efflux protein; Region: OEP; pfam02321 189518003790 potential frameshift: common BLAST hit: gi|45657799|ref|YP_001885.1| heavy metal efflux pump 189518003791 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 189518003792 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 189518003793 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 189518003794 MMPL family; Region: MMPL; cl14618 189518003795 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 189518003796 MMPL family; Region: MMPL; cl14618 189518003797 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 189518003798 MMPL family; Region: MMPL; cl14618 189518003799 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 189518003800 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 189518003801 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 189518003802 active site 189518003803 NTP binding site [chemical binding]; other site 189518003804 metal binding triad [ion binding]; metal-binding site 189518003805 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 189518003806 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 189518003807 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 189518003808 RNA/DNA hybrid binding site [nucleotide binding]; other site 189518003809 active site 189518003810 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 189518003811 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 189518003812 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 189518003813 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189518003814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518003815 NAD(P) binding site [chemical binding]; other site 189518003816 active site 189518003817 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189518003818 FAD binding domain; Region: FAD_binding_4; pfam01565 189518003819 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 189518003820 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 189518003821 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 189518003822 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 189518003823 Ligand binding site; other site 189518003824 Putative Catalytic site; other site 189518003825 DXD motif; other site 189518003826 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 189518003827 O-Antigen ligase; Region: Wzy_C; pfam04932 189518003828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518003829 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 189518003830 Protein of unknown function (DUF1577); Region: DUF1577; pfam07614 189518003831 inosine-5'-monophosphate dehydrogenase; Provisional; Region: PTZ00314 189518003832 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 189518003833 active site 189518003834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 189518003835 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 189518003836 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 189518003837 thiamine phosphate binding site [chemical binding]; other site 189518003838 active site 189518003839 pyrophosphate binding site [ion binding]; other site 189518003840 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 189518003841 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 189518003842 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 189518003843 dimer interface [polypeptide binding]; other site 189518003844 putative anticodon binding site; other site 189518003845 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 189518003846 motif 1; other site 189518003847 active site 189518003848 motif 2; other site 189518003849 motif 3; other site 189518003850 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 189518003851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518003852 active site 189518003853 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 189518003854 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 189518003855 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 189518003856 putative active site [active] 189518003857 putative metal binding site [ion binding]; other site 189518003858 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 189518003859 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 189518003860 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518003861 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 189518003862 FliG N-terminal domain; Region: FliG_N; pfam14842 189518003863 FliG middle domain; Region: FliG_M; pfam14841 189518003864 FliG C-terminal domain; Region: FliG_C; pfam01706 189518003865 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 189518003866 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189518003867 E3 interaction surface; other site 189518003868 lipoyl attachment site [posttranslational modification]; other site 189518003869 Ustilago B locus mating-type protein; Region: Ustilago_mating; pfam05722 189518003870 e3 binding domain; Region: E3_binding; pfam02817 189518003871 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 189518003872 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 189518003873 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 189518003874 alpha subunit interface [polypeptide binding]; other site 189518003875 TPP binding site [chemical binding]; other site 189518003876 heterodimer interface [polypeptide binding]; other site 189518003877 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189518003878 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 189518003879 tetramer interface [polypeptide binding]; other site 189518003880 TPP-binding site [chemical binding]; other site 189518003881 heterodimer interface [polypeptide binding]; other site 189518003882 phosphorylation loop region [posttranslational modification] 189518003883 DNA-binding response regulator CreB; Provisional; Region: PRK11083 189518003884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518003885 active site 189518003886 phosphorylation site [posttranslational modification] 189518003887 intermolecular recognition site; other site 189518003888 dimerization interface [polypeptide binding]; other site 189518003889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189518003890 DNA binding site [nucleotide binding] 189518003891 sensory histidine kinase CreC; Provisional; Region: PRK11100 189518003892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518003893 ATP binding site [chemical binding]; other site 189518003894 Mg2+ binding site [ion binding]; other site 189518003895 G-X-G motif; other site 189518003896 inner membrane protein; Provisional; Region: PRK11715 189518003897 flagellin; Provisional; Region: PRK12804 189518003898 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 189518003899 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 189518003900 flagellin; Provisional; Region: PRK12804 189518003901 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 189518003902 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 189518003903 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 189518003904 Cytochrome c; Region: Cytochrom_C; pfam00034 189518003905 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 189518003906 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 189518003907 prohibitin homologues; Region: PHB; smart00244 189518003908 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 189518003909 Peptidase family M48; Region: Peptidase_M48; cl12018 189518003910 TIGR02453 family protein; Region: TIGR02453 189518003911 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518003912 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 189518003913 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 189518003914 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 189518003915 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 189518003916 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 189518003917 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 189518003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003919 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 189518003920 nucleotide binding site/active site [active] 189518003921 HIT family signature motif; other site 189518003922 catalytic residue [active] 189518003923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518003924 Cell division protein FtsL; Region: FtsL; cl11433 189518003925 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 189518003926 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189518003927 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189518003928 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 189518003929 Mg++ binding site [ion binding]; other site 189518003930 putative catalytic motif [active] 189518003931 putative substrate binding site [chemical binding]; other site 189518003932 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 189518003933 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 189518003934 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 189518003935 active site 189518003936 homodimer interface [polypeptide binding]; other site 189518003937 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 189518003938 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 189518003939 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189518003940 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189518003941 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 189518003942 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 189518003943 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 189518003944 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 189518003945 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 189518003946 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 189518003947 mce related protein; Region: MCE; pfam02470 189518003948 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 189518003949 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 189518003950 Walker A/P-loop; other site 189518003951 ATP binding site [chemical binding]; other site 189518003952 Q-loop/lid; other site 189518003953 ABC transporter signature motif; other site 189518003954 Walker B; other site 189518003955 D-loop; other site 189518003956 H-loop/switch region; other site 189518003957 Permease; Region: Permease; pfam02405 189518003958 D-alanyl-alanine synthetase A; Provisional; Region: PRK14572 189518003959 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 189518003960 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518003961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518003962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518003963 S-adenosylmethionine binding site [chemical binding]; other site 189518003964 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 189518003965 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 189518003966 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 189518003967 homodimer interface [polypeptide binding]; other site 189518003968 substrate-cofactor binding pocket; other site 189518003969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518003970 catalytic residue [active] 189518003971 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 189518003972 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189518003973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518003974 Walker A motif; other site 189518003975 ATP binding site [chemical binding]; other site 189518003976 Walker B motif; other site 189518003977 arginine finger; other site 189518003978 flagellar motor switch protein FliN; Region: fliN; TIGR02480 189518003979 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 189518003980 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 189518003981 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 189518003982 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 189518003983 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 189518003984 Haem-binding domain; Region: Haem_bd; pfam14376 189518003985 argininosuccinate lyase; Provisional; Region: PRK00855 189518003986 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 189518003987 active sites [active] 189518003988 tetramer interface [polypeptide binding]; other site 189518003989 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 189518003990 active site 189518003991 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 189518003992 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 189518003993 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 189518003994 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 189518003995 FecR protein; Region: FecR; pfam04773 189518003996 Rotavirus VP2 protein; Region: Rota_VP2; pfam05087 189518003997 AAA domain; Region: AAA_17; cl19128 189518003998 Uncharacterized conserved protein [Function unknown]; Region: COG4095 189518003999 GMP synthase; Reviewed; Region: guaA; PRK00074 189518004000 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 189518004001 AMP/PPi binding site [chemical binding]; other site 189518004002 candidate oxyanion hole; other site 189518004003 catalytic triad [active] 189518004004 potential glutamine specificity residues [chemical binding]; other site 189518004005 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 189518004006 ATP Binding subdomain [chemical binding]; other site 189518004007 Ligand Binding sites [chemical binding]; other site 189518004008 Dimerization subdomain; other site 189518004009 Domain of unknown function (DUF4505); Region: DUF4505; pfam14956 189518004010 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 189518004011 O-Antigen ligase; Region: Wzy_C; pfam04932 189518004012 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 189518004013 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 189518004014 putative metal binding site; other site 189518004015 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 189518004016 dimer interface [polypeptide binding]; other site 189518004017 active site 189518004018 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 189518004019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518004020 Walker A/P-loop; other site 189518004021 ATP binding site [chemical binding]; other site 189518004022 Q-loop/lid; other site 189518004023 ABC transporter signature motif; other site 189518004024 Walker B; other site 189518004025 D-loop; other site 189518004026 H-loop/switch region; other site 189518004027 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 189518004028 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 189518004029 phosphopeptide binding site; other site 189518004030 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 189518004031 substrate binding site [chemical binding]; other site 189518004032 ligand binding site [chemical binding]; other site 189518004033 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 189518004034 substrate binding site [chemical binding]; other site 189518004035 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 189518004036 dimer interface [polypeptide binding]; other site 189518004037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518004038 catalytic residue [active] 189518004039 AAA domain; Region: AAA_11; pfam13086 189518004040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518004041 ATP binding site [chemical binding]; other site 189518004042 AAA domain; Region: AAA_12; pfam13087 189518004043 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189518004044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518004045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518004046 DNA binding residues [nucleotide binding] 189518004047 Protein of unknown function, DUF482; Region: DUF482; pfam04339 189518004048 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 189518004049 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 189518004050 Clp amino terminal domain; Region: Clp_N; pfam02861 189518004051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004052 Walker A motif; other site 189518004053 ATP binding site [chemical binding]; other site 189518004054 Walker B motif; other site 189518004055 arginine finger; other site 189518004056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004057 Walker A motif; other site 189518004058 ATP binding site [chemical binding]; other site 189518004059 Walker B motif; other site 189518004060 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 189518004061 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 189518004062 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 189518004063 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 189518004064 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518004065 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 189518004066 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 189518004067 putative GSH binding site [chemical binding]; other site 189518004068 catalytic residues [active] 189518004069 BolA-like protein; Region: BolA; pfam01722 189518004070 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 189518004071 inner membrane transport permease; Provisional; Region: PRK15066 189518004072 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 189518004073 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189518004074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518004075 Walker A/P-loop; other site 189518004076 ATP binding site [chemical binding]; other site 189518004077 Q-loop/lid; other site 189518004078 ABC transporter signature motif; other site 189518004079 Walker B; other site 189518004080 D-loop; other site 189518004081 H-loop/switch region; other site 189518004082 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 189518004083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518004084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189518004085 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 189518004086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189518004087 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518004088 anti sigma factor interaction site; other site 189518004089 regulatory phosphorylation site [posttranslational modification]; other site 189518004090 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 189518004091 glycerol kinase; Provisional; Region: glpK; PRK00047 189518004092 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 189518004093 N- and C-terminal domain interface [polypeptide binding]; other site 189518004094 active site 189518004095 MgATP binding site [chemical binding]; other site 189518004096 catalytic site [active] 189518004097 metal binding site [ion binding]; metal-binding site 189518004098 glycerol binding site [chemical binding]; other site 189518004099 homotetramer interface [polypeptide binding]; other site 189518004100 homodimer interface [polypeptide binding]; other site 189518004101 FBP binding site [chemical binding]; other site 189518004102 protein IIAGlc interface [polypeptide binding]; other site 189518004103 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518004104 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518004105 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 189518004106 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 189518004107 tandem repeat interface [polypeptide binding]; other site 189518004108 oligomer interface [polypeptide binding]; other site 189518004109 active site residues [active] 189518004110 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 189518004111 active site 189518004112 catalytic residues [active] 189518004113 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 189518004114 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 189518004115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518004116 ATP binding site [chemical binding]; other site 189518004117 putative Mg++ binding site [ion binding]; other site 189518004118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518004119 nucleotide binding region [chemical binding]; other site 189518004120 ATP-binding site [chemical binding]; other site 189518004121 aspartate aminotransferase; Provisional; Region: PRK05764 189518004122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518004123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518004124 homodimer interface [polypeptide binding]; other site 189518004125 catalytic residue [active] 189518004126 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 189518004127 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518004128 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518004129 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 189518004130 Na binding site [ion binding]; other site 189518004131 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 189518004132 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 189518004133 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 189518004134 Thioredoxin; Region: Thioredoxin_4; pfam13462 189518004135 malate dehydrogenase; Provisional; Region: PRK05442 189518004136 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 189518004137 NAD(P) binding site [chemical binding]; other site 189518004138 dimer interface [polypeptide binding]; other site 189518004139 malate binding site [chemical binding]; other site 189518004140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 189518004141 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 189518004142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518004143 catalytic residue [active] 189518004144 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 189518004145 AAA domain; Region: AAA_26; pfam13500 189518004146 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 189518004147 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189518004148 inhibitor-cofactor binding pocket; inhibition site 189518004149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518004150 catalytic residue [active] 189518004151 biotin synthase; Region: bioB; TIGR00433 189518004152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518004153 FeS/SAM binding site; other site 189518004154 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 189518004155 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 189518004156 active site 189518004157 catalytic triad [active] 189518004158 oxyanion hole [active] 189518004159 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 189518004160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189518004161 motif II; other site 189518004162 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 189518004163 MutS domain I; Region: MutS_I; pfam01624 189518004164 MutS domain II; Region: MutS_II; pfam05188 189518004165 MutS domain III; Region: MutS_III; pfam05192 189518004166 MutS domain V; Region: MutS_V; pfam00488 189518004167 Walker A/P-loop; other site 189518004168 ATP binding site [chemical binding]; other site 189518004169 Q-loop/lid; other site 189518004170 ABC transporter signature motif; other site 189518004171 Walker B; other site 189518004172 D-loop; other site 189518004173 H-loop/switch region; other site 189518004174 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 189518004175 active site 189518004176 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 189518004177 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518004178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004179 active site 189518004180 phosphorylation site [posttranslational modification] 189518004181 intermolecular recognition site; other site 189518004182 dimerization interface [polypeptide binding]; other site 189518004183 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 189518004184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189518004185 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 189518004186 inhibitor-cofactor binding pocket; inhibition site 189518004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518004188 catalytic residue [active] 189518004189 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 189518004190 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 189518004191 active site 189518004192 substrate binding site [chemical binding]; other site 189518004193 metal binding site [ion binding]; metal-binding site 189518004194 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 189518004195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518004196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518004197 homodimer interface [polypeptide binding]; other site 189518004198 catalytic residue [active] 189518004199 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 189518004200 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 189518004201 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189518004202 minor groove reading motif; other site 189518004203 helix-hairpin-helix signature motif; other site 189518004204 substrate binding pocket [chemical binding]; other site 189518004205 active site 189518004206 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 189518004207 RF-1 domain; Region: RF-1; pfam00472 189518004208 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 189518004209 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 189518004210 GIY-YIG motif/motif A; other site 189518004211 active site 189518004212 catalytic site [active] 189518004213 putative DNA binding site [nucleotide binding]; other site 189518004214 metal binding site [ion binding]; metal-binding site 189518004215 UvrB/uvrC motif; Region: UVR; pfam02151 189518004216 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 189518004217 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 189518004218 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 189518004219 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 189518004220 putative active site [active] 189518004221 catalytic site [active] 189518004222 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 189518004223 putative active site [active] 189518004224 catalytic site [active] 189518004225 O-Antigen ligase; Region: Wzy_C; pfam04932 189518004226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518004227 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 189518004228 putative ADP-binding pocket [chemical binding]; other site 189518004229 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 189518004230 putative active site [active] 189518004231 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 189518004232 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518004233 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518004234 ligand binding site [chemical binding]; other site 189518004235 flexible hinge region; other site 189518004236 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 189518004237 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 189518004238 nucleophile elbow; other site 189518004239 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 189518004240 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189518004241 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 189518004242 acyl-activating enzyme (AAE) consensus motif; other site 189518004243 putative AMP binding site [chemical binding]; other site 189518004244 putative active site [active] 189518004245 putative CoA binding site [chemical binding]; other site 189518004246 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 189518004247 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 189518004248 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 189518004249 recombinase A; Provisional; Region: recA; PRK09354 189518004250 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 189518004251 hexamer interface [polypeptide binding]; other site 189518004252 Walker A motif; other site 189518004253 ATP binding site [chemical binding]; other site 189518004254 Walker B motif; other site 189518004255 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 189518004256 nucleotide binding site/active site [active] 189518004257 HIT family signature motif; other site 189518004258 catalytic residue [active] 189518004259 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 189518004260 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 189518004261 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 189518004262 MG2 domain; Region: A2M_N; pfam01835 189518004263 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 189518004264 Alpha-2-macroglobulin family; Region: A2M; pfam00207 189518004265 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 189518004266 Transglycosylase; Region: Transgly; pfam00912 189518004267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189518004268 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 189518004269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004270 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 189518004271 Walker A motif; other site 189518004272 ATP binding site [chemical binding]; other site 189518004273 Walker B motif; other site 189518004274 arginine finger; other site 189518004275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 189518004276 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 189518004277 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 189518004278 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 189518004279 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 189518004280 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 189518004281 Part of AAA domain; Region: AAA_19; pfam13245 189518004282 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 189518004283 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl19519 189518004284 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 189518004285 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518004286 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518004287 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 189518004288 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 189518004289 active site 189518004290 FMN binding site [chemical binding]; other site 189518004291 2,4-decadienoyl-CoA binding site; other site 189518004292 catalytic residue [active] 189518004293 4Fe-4S cluster binding site [ion binding]; other site 189518004294 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 189518004295 amidase catalytic site [active] 189518004296 Zn binding residues [ion binding]; other site 189518004297 substrate binding site [chemical binding]; other site 189518004298 2-isopropylmalate synthase; Validated; Region: PRK00915 189518004299 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 189518004300 active site 189518004301 catalytic residues [active] 189518004302 metal binding site [ion binding]; metal-binding site 189518004303 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 189518004304 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189518004305 active site 189518004306 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 189518004307 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 189518004308 active site 189518004309 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 189518004310 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 189518004311 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 189518004312 active site 189518004313 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 189518004314 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 189518004315 tandem repeat interface [polypeptide binding]; other site 189518004316 oligomer interface [polypeptide binding]; other site 189518004317 active site residues [active] 189518004318 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 189518004319 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 189518004320 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 189518004321 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 189518004322 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518004323 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 189518004324 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 189518004325 Conserved oligomeric complex COG6; Region: COG6; cl19764 189518004326 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518004327 ligand binding site [chemical binding]; other site 189518004328 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 189518004329 MgtE intracellular N domain; Region: MgtE_N; pfam03448 189518004330 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 189518004331 Divalent cation transporter; Region: MgtE; cl00786 189518004332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 189518004333 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 189518004334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189518004335 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189518004336 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 189518004337 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 189518004338 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189518004339 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 189518004340 PAS domain; Region: PAS; smart00091 189518004341 PAS fold; Region: PAS_4; pfam08448 189518004342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518004343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518004344 dimer interface [polypeptide binding]; other site 189518004345 phosphorylation site [posttranslational modification] 189518004346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004347 ATP binding site [chemical binding]; other site 189518004348 Mg2+ binding site [ion binding]; other site 189518004349 G-X-G motif; other site 189518004350 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518004351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004352 active site 189518004353 phosphorylation site [posttranslational modification] 189518004354 intermolecular recognition site; other site 189518004355 dimerization interface [polypeptide binding]; other site 189518004356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518004357 dimer interface [polypeptide binding]; other site 189518004358 phosphorylation site [posttranslational modification] 189518004359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004360 ATP binding site [chemical binding]; other site 189518004361 Mg2+ binding site [ion binding]; other site 189518004362 G-X-G motif; other site 189518004363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004364 active site 189518004365 phosphorylation site [posttranslational modification] 189518004366 intermolecular recognition site; other site 189518004367 dimerization interface [polypeptide binding]; other site 189518004368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518004370 dimer interface [polypeptide binding]; other site 189518004371 phosphorylation site [posttranslational modification] 189518004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004373 ATP binding site [chemical binding]; other site 189518004374 Mg2+ binding site [ion binding]; other site 189518004375 G-X-G motif; other site 189518004376 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 189518004377 AMP binding site [chemical binding]; other site 189518004378 metal binding site [ion binding]; metal-binding site 189518004379 active site 189518004380 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 189518004381 Yqey-like protein; Region: YqeY; pfam09424 189518004382 CHC2 zinc finger; Region: zf-CHC2; cl17510 189518004383 DNA primase; Validated; Region: dnaG; PRK05667 189518004384 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 189518004385 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 189518004386 active site 189518004387 metal binding site [ion binding]; metal-binding site 189518004388 interdomain interaction site; other site 189518004389 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 189518004390 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 189518004391 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 189518004392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518004393 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 189518004394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518004395 DNA binding residues [nucleotide binding] 189518004396 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 189518004397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518004398 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 189518004399 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 189518004400 active site 189518004401 HIGH motif; other site 189518004402 dimer interface [polypeptide binding]; other site 189518004403 KMSKS motif; other site 189518004404 S4 domain; Region: S4; pfam01479 189518004405 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 189518004406 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 189518004407 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 189518004408 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518004409 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 189518004410 hydrophobic ligand binding site; other site 189518004411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518004412 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518004413 dimer interface [polypeptide binding]; other site 189518004414 putative CheW interface [polypeptide binding]; other site 189518004415 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 189518004416 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 189518004417 active site 189518004418 Zn binding site [ion binding]; other site 189518004419 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 189518004420 PHP domain; Region: PHP; pfam02811 189518004421 active site 189518004422 DJ-1 family protein; Region: not_thiJ; TIGR01383 189518004423 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 189518004424 conserved cys residue [active] 189518004425 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 189518004426 NAD+ binding site [chemical binding]; other site 189518004427 substrate binding site [chemical binding]; other site 189518004428 Zn binding site [ion binding]; other site 189518004429 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 189518004430 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 189518004431 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518004432 YacP-like NYN domain; Region: NYN_YacP; pfam05991 189518004433 Protein of unknown function (DUF962); Region: DUF962; cl01879 189518004434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518004435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518004436 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 189518004437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518004438 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189518004439 FAD binding domain; Region: FAD_binding_4; pfam01565 189518004440 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 189518004441 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518004442 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 189518004443 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518004444 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518004445 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518004446 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518004447 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518004448 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189518004449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518004450 substrate binding site [chemical binding]; other site 189518004451 oxyanion hole (OAH) forming residues; other site 189518004452 trimer interface [polypeptide binding]; other site 189518004453 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 189518004454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518004455 binding surface 189518004456 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518004457 TPR motif; other site 189518004458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518004459 binding surface 189518004460 TPR motif; other site 189518004461 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518004462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518004463 binding surface 189518004464 TPR motif; other site 189518004465 TPR repeat; Region: TPR_11; pfam13414 189518004466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518004467 binding surface 189518004468 TPR motif; other site 189518004469 TPR repeat; Region: TPR_11; pfam13414 189518004470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518004471 binding surface 189518004472 TPR motif; other site 189518004473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518004474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 189518004475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518004476 catalytic residue [active] 189518004477 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 189518004478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518004479 Zn2+ binding site [ion binding]; other site 189518004480 Mg2+ binding site [ion binding]; other site 189518004481 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 189518004482 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 189518004483 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 189518004484 active site 189518004485 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 189518004486 HSP70 interaction site [polypeptide binding]; other site 189518004487 Flagellar protein FliS; Region: FliS; cl00654 189518004488 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 189518004489 active site 189518004490 substrate binding site [chemical binding]; other site 189518004491 cosubstrate binding site; other site 189518004492 catalytic site [active] 189518004493 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 189518004494 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 189518004495 purine monophosphate binding site [chemical binding]; other site 189518004496 dimer interface [polypeptide binding]; other site 189518004497 putative catalytic residues [active] 189518004498 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 189518004499 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 189518004500 active site 189518004501 intersubunit interactions; other site 189518004502 catalytic residue [active] 189518004503 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 189518004504 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518004505 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 189518004506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 189518004507 RNA binding surface [nucleotide binding]; other site 189518004508 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 189518004509 active site 189518004510 lipoyl synthase; Provisional; Region: PRK05481 189518004511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518004512 FeS/SAM binding site; other site 189518004513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518004514 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518004515 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518004516 FecR protein; Region: FecR; pfam04773 189518004517 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 189518004518 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 189518004519 Type II restriction endonuclease (RE_Alw26IDE); Region: RE_Alw26IDE; cl19566 189518004520 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 189518004521 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 189518004522 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 189518004523 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 189518004524 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 189518004525 short chain dehydrogenase; Region: adh_short; pfam00106 189518004526 NADP binding site [chemical binding]; other site 189518004527 homodimer interface [polypeptide binding]; other site 189518004528 active site 189518004529 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 189518004530 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 189518004531 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 189518004532 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 189518004533 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 189518004534 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 189518004535 RNA binding; Region: RNA_binding; cl00585 189518004536 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189518004537 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 189518004538 acyl-activating enzyme (AAE) consensus motif; other site 189518004539 putative AMP binding site [chemical binding]; other site 189518004540 putative active site [active] 189518004541 putative CoA binding site [chemical binding]; other site 189518004542 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 189518004543 catalytic residues [active] 189518004544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518004545 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 189518004546 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 189518004547 active site 189518004548 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 189518004549 Part of AAA domain; Region: AAA_19; pfam13245 189518004550 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 189518004551 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 189518004552 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 189518004553 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 189518004554 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 189518004555 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 189518004556 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 189518004557 Surface antigen; Region: Bac_surface_Ag; pfam01103 189518004558 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 189518004559 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 189518004560 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 189518004561 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 189518004562 Walker A/P-loop; other site 189518004563 ATP binding site [chemical binding]; other site 189518004564 Q-loop/lid; other site 189518004565 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 189518004566 ABC transporter signature motif; other site 189518004567 Walker B; other site 189518004568 D-loop; other site 189518004569 H-loop/switch region; other site 189518004570 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 189518004571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518004572 NAD(P) binding site [chemical binding]; other site 189518004573 active site 189518004574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189518004575 dimerization interface [polypeptide binding]; other site 189518004576 putative DNA binding site [nucleotide binding]; other site 189518004577 putative Zn2+ binding site [ion binding]; other site 189518004578 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 189518004579 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 189518004580 NADP binding site [chemical binding]; other site 189518004581 homopentamer interface [polypeptide binding]; other site 189518004582 substrate binding site [chemical binding]; other site 189518004583 active site 189518004584 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 189518004585 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 189518004586 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 189518004587 minor groove reading motif; other site 189518004588 helix-hairpin-helix signature motif; other site 189518004589 substrate binding pocket [chemical binding]; other site 189518004590 active site 189518004591 GTP-binding protein YchF; Reviewed; Region: PRK09601 189518004592 YchF GTPase; Region: YchF; cd01900 189518004593 G1 box; other site 189518004594 GTP/Mg2+ binding site [chemical binding]; other site 189518004595 Switch I region; other site 189518004596 G2 box; other site 189518004597 Switch II region; other site 189518004598 G3 box; other site 189518004599 G4 box; other site 189518004600 G5 box; other site 189518004601 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 189518004602 translation initiation factor 2; Provisional; Region: infB; CHL00189 189518004603 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 189518004604 dinuclear metal binding motif [ion binding]; other site 189518004605 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 189518004606 putative active site [active] 189518004607 Flavoprotein; Region: Flavoprotein; cl19190 189518004608 Domain of unknown function DUF59; Region: DUF59; pfam01883 189518004609 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 189518004610 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 189518004611 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 189518004612 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 189518004613 putative active site [active] 189518004614 putative metal binding site [ion binding]; other site 189518004615 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 189518004616 E3 interaction surface; other site 189518004617 lipoyl attachment site [posttranslational modification]; other site 189518004618 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 189518004619 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 189518004620 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 189518004621 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 189518004622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004623 Walker A motif; other site 189518004624 ATP binding site [chemical binding]; other site 189518004625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004626 Walker B motif; other site 189518004627 arginine finger; other site 189518004628 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 189518004629 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 189518004630 active site 189518004631 HslU subunit interaction site [polypeptide binding]; other site 189518004632 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 189518004633 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 189518004634 active site 189518004635 Int/Topo IB signature motif; other site 189518004636 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 189518004637 putative active site [active] 189518004638 catalytic residue [active] 189518004639 (R)-citramalate synthase; Provisional; Region: PRK09389 189518004640 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 189518004641 active site 189518004642 catalytic residues [active] 189518004643 metal binding site [ion binding]; metal-binding site 189518004644 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 189518004645 Smr domain; Region: Smr; pfam01713 189518004646 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl19874 189518004647 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 189518004648 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 189518004649 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 189518004650 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 189518004651 generic binding surface II; other site 189518004652 generic binding surface I; other site 189518004653 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14069 189518004654 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 189518004655 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 189518004656 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 189518004657 active site 189518004658 dimer interface [polypeptide binding]; other site 189518004659 effector binding site; other site 189518004660 TSCPD domain; Region: TSCPD; pfam12637 189518004661 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189518004662 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 189518004663 Cell division protein FtsA; Region: FtsA; pfam14450 189518004664 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 189518004665 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 189518004666 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 189518004667 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 189518004668 Type II secretion system (T2SS), protein J; Region: T2SJ; cl19722 189518004669 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 189518004670 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 189518004671 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 189518004672 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 189518004673 type II secretion system protein F; Region: GspF; TIGR02120 189518004674 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 189518004675 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 189518004676 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 189518004677 type II secretion system protein E; Region: type_II_gspE; TIGR02533 189518004678 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 189518004679 Walker A motif; other site 189518004680 ATP binding site [chemical binding]; other site 189518004681 Walker B motif; other site 189518004682 type II secretion system protein D; Region: type_II_gspD; TIGR02517 189518004683 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 189518004684 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 189518004685 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 189518004686 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 189518004687 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 189518004688 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 189518004689 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518004690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518004691 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518004692 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 189518004693 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 189518004694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004695 Walker A motif; other site 189518004696 ATP binding site [chemical binding]; other site 189518004697 Walker B motif; other site 189518004698 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 189518004699 hypothetical protein; Reviewed; Region: PRK12497 189518004700 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 189518004701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518004702 Zn2+ binding site [ion binding]; other site 189518004703 Mg2+ binding site [ion binding]; other site 189518004704 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 189518004705 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 189518004706 RNA/DNA hybrid binding site [nucleotide binding]; other site 189518004707 active site 189518004708 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 189518004709 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Provisional; Region: trmD; PRK14599 189518004710 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14590 189518004711 RimM N-terminal domain; Region: RimM; pfam01782 189518004712 PRC-barrel domain; Region: PRC; pfam05239 189518004713 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 189518004714 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 189518004715 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 189518004716 substrate binding site [chemical binding]; other site 189518004717 hexamer interface [polypeptide binding]; other site 189518004718 metal binding site [ion binding]; metal-binding site 189518004719 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 189518004720 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 189518004721 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 189518004722 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 189518004723 putative active site [active] 189518004724 substrate binding site [chemical binding]; other site 189518004725 putative cosubstrate binding site; other site 189518004726 catalytic site [active] 189518004727 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 189518004728 substrate binding site [chemical binding]; other site 189518004729 primosome assembly protein PriA; Validated; Region: PRK05580 189518004730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518004731 ATP binding site [chemical binding]; other site 189518004732 putative Mg++ binding site [ion binding]; other site 189518004733 helicase superfamily c-terminal domain; Region: HELICc; smart00490 189518004734 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 189518004735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004736 active site 189518004737 phosphorylation site [posttranslational modification] 189518004738 intermolecular recognition site; other site 189518004739 dimerization interface [polypeptide binding]; other site 189518004740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518004741 Walker A motif; other site 189518004742 ATP binding site [chemical binding]; other site 189518004743 Walker B motif; other site 189518004744 arginine finger; other site 189518004745 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 189518004746 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 189518004747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518004748 dimerization interface [polypeptide binding]; other site 189518004749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518004750 dimer interface [polypeptide binding]; other site 189518004751 phosphorylation site [posttranslational modification] 189518004752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004753 ATP binding site [chemical binding]; other site 189518004754 Mg2+ binding site [ion binding]; other site 189518004755 G-X-G motif; other site 189518004756 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 189518004757 dimerization domain swap beta strand [polypeptide binding]; other site 189518004758 regulatory protein interface [polypeptide binding]; other site 189518004759 active site 189518004760 regulatory phosphorylation site [posttranslational modification]; other site 189518004761 HPr kinase/phosphorylase; Provisional; Region: PRK05428 189518004762 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 189518004763 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 189518004764 Hpr binding site; other site 189518004765 active site 189518004766 homohexamer subunit interaction site [polypeptide binding]; other site 189518004767 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 189518004768 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 189518004769 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 189518004770 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 189518004771 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 189518004772 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 189518004773 Walker A/P-loop; other site 189518004774 ATP binding site [chemical binding]; other site 189518004775 Q-loop/lid; other site 189518004776 ABC transporter signature motif; other site 189518004777 Walker B; other site 189518004778 D-loop; other site 189518004779 H-loop/switch region; other site 189518004780 OstA-like protein; Region: OstA; cl00844 189518004781 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 189518004782 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 189518004783 CTP synthetase; Validated; Region: pyrG; PRK05380 189518004784 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 189518004785 Catalytic site [active] 189518004786 active site 189518004787 UTP binding site [chemical binding]; other site 189518004788 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 189518004789 active site 189518004790 putative oxyanion hole; other site 189518004791 catalytic triad [active] 189518004792 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 189518004793 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 189518004794 active site 189518004795 nucleotide binding site [chemical binding]; other site 189518004796 HIGH motif; other site 189518004797 KMSKS motif; other site 189518004798 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 189518004799 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 189518004800 putative ribose interaction site [chemical binding]; other site 189518004801 putative ADP binding site [chemical binding]; other site 189518004802 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 189518004803 NlpC/P60 family; Region: NLPC_P60; pfam00877 189518004804 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 189518004805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518004806 putative substrate translocation pore; other site 189518004807 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 189518004808 flagellin; Provisional; Region: PRK12804 189518004809 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 189518004810 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 189518004811 flagellin; Provisional; Region: PRK12804 189518004812 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 189518004813 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 189518004814 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518004815 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 189518004816 Fe-S cluster binding site [ion binding]; other site 189518004817 substrate binding site [chemical binding]; other site 189518004818 catalytic site [active] 189518004819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518004820 PAS domain; Region: PAS_9; pfam13426 189518004821 putative active site [active] 189518004822 heme pocket [chemical binding]; other site 189518004823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518004824 dimer interface [polypeptide binding]; other site 189518004825 phosphorylation site [posttranslational modification] 189518004826 Pleckstrin homology-like domain; Region: PH-like; cl17171 189518004827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004828 ATP binding site [chemical binding]; other site 189518004829 Mg2+ binding site [ion binding]; other site 189518004830 G-X-G motif; other site 189518004831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004832 active site 189518004833 phosphorylation site [posttranslational modification] 189518004834 intermolecular recognition site; other site 189518004835 dimerization interface [polypeptide binding]; other site 189518004836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004837 ATP binding site [chemical binding]; other site 189518004838 Mg2+ binding site [ion binding]; other site 189518004839 G-X-G motif; other site 189518004840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004841 active site 189518004842 phosphorylation site [posttranslational modification] 189518004843 intermolecular recognition site; other site 189518004844 dimerization interface [polypeptide binding]; other site 189518004845 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518004846 anti sigma factor interaction site; other site 189518004847 regulatory phosphorylation site [posttranslational modification]; other site 189518004848 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 189518004849 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 189518004850 putative binding surface; other site 189518004851 active site 189518004852 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 189518004853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004854 ATP binding site [chemical binding]; other site 189518004855 Mg2+ binding site [ion binding]; other site 189518004856 G-X-G motif; other site 189518004857 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 189518004858 Putative methyltransferase; Region: Methyltransf_4; cl17290 189518004859 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518004860 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518004861 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 189518004862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518004863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 189518004864 dimer interface [polypeptide binding]; other site 189518004865 putative CheW interface [polypeptide binding]; other site 189518004866 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 189518004867 CheD chemotactic sensory transduction; Region: CheD; cl00810 189518004868 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 189518004869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518004870 active site 189518004871 phosphorylation site [posttranslational modification] 189518004872 intermolecular recognition site; other site 189518004873 dimerization interface [polypeptide binding]; other site 189518004874 CheB methylesterase; Region: CheB_methylest; pfam01339 189518004875 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 189518004876 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 189518004877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189518004878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518004879 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 189518004880 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189518004881 carboxyltransferase (CT) interaction site; other site 189518004882 biotinylation site [posttranslational modification]; other site 189518004883 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 189518004884 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 189518004885 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 189518004886 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 189518004887 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518004888 anti sigma factor interaction site; other site 189518004889 regulatory phosphorylation site [posttranslational modification]; other site 189518004890 GAF domain; Region: GAF; pfam01590 189518004891 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189518004892 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 189518004893 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518004894 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189518004895 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 189518004896 active site 189518004897 catalytic residues [active] 189518004898 metal binding site [ion binding]; metal-binding site 189518004899 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518004900 MMPL family; Region: MMPL; cl14618 189518004901 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 189518004902 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 189518004903 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 189518004904 Leucine rich repeat; Region: LRR_8; pfam13855 189518004905 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004906 Leucine rich repeat; Region: LRR_8; pfam13855 189518004907 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004908 Leucine rich repeat; Region: LRR_8; pfam13855 189518004909 outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327 189518004910 tyrosine kinase; Provisional; Region: PRK11519 189518004911 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518004912 Leucine rich repeat; Region: LRR_8; pfam13855 189518004913 Leucine-rich repeats; other site 189518004914 Substrate binding site [chemical binding]; other site 189518004915 Leucine rich repeat; Region: LRR_8; pfam13855 189518004916 Leucine rich repeat; Region: LRR_8; pfam13855 189518004917 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518004918 Leucine rich repeat; Region: LRR_8; pfam13855 189518004919 Leucine-rich repeats; other site 189518004920 Substrate binding site [chemical binding]; other site 189518004921 Leucine rich repeat; Region: LRR_8; pfam13855 189518004922 Leucine rich repeat; Region: LRR_8; pfam13855 189518004923 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518004924 Leucine rich repeat; Region: LRR_8; pfam13855 189518004925 Leucine-rich repeats; other site 189518004926 Substrate binding site [chemical binding]; other site 189518004927 Leucine rich repeat; Region: LRR_8; pfam13855 189518004928 Leucine rich repeat; Region: LRR_8; pfam13855 189518004929 Leucine rich repeat; Region: LRR_8; pfam13855 189518004930 Leucine rich repeat; Region: LRR_8; pfam13855 189518004931 Leucine rich repeat; Region: LRR_8; pfam13855 189518004932 Leucine rich repeat; Region: LRR_8; pfam13855 189518004933 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004934 Leucine rich repeat; Region: LRR_8; pfam13855 189518004935 Leucine rich repeat; Region: LRR_8; pfam13855 189518004936 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004937 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004938 Leucine rich repeat; Region: LRR_8; pfam13855 189518004939 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004940 Leucine rich repeat; Region: LRR_8; pfam13855 189518004941 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004942 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518004943 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 189518004944 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 189518004945 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 189518004946 Predicted membrane protein [Function unknown]; Region: COG3766 189518004947 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 189518004948 Predicted membrane protein [Function unknown]; Region: COG3766 189518004949 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 189518004950 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 189518004951 active site 189518004952 TerB-C domain; Region: TerB-C; pfam15615 189518004953 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 189518004954 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 189518004955 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518004957 S-adenosylmethionine binding site [chemical binding]; other site 189518004958 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 189518004959 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189518004960 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189518004961 Walker A/P-loop; other site 189518004962 ATP binding site [chemical binding]; other site 189518004963 Q-loop/lid; other site 189518004964 ABC transporter signature motif; other site 189518004965 Walker B; other site 189518004966 D-loop; other site 189518004967 H-loop/switch region; other site 189518004968 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 189518004969 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 189518004970 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 189518004971 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 189518004972 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 189518004973 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 189518004974 Guanylate-binding protein, C-terminal domain; Region: GBP_C; pfam02841 189518004975 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 189518004976 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 189518004977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518004978 binding surface 189518004979 TPR motif; other site 189518004980 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518004981 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518004982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518004983 ligand binding site [chemical binding]; other site 189518004984 flexible hinge region; other site 189518004985 putative switch regulator; other site 189518004986 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 189518004987 non-specific DNA interactions [nucleotide binding]; other site 189518004988 DNA binding site [nucleotide binding] 189518004989 sequence specific DNA binding site [nucleotide binding]; other site 189518004990 putative cAMP binding site [chemical binding]; other site 189518004991 Protein of unknown function (DUF342); Region: DUF342; pfam03961 189518004992 TfoX N-terminal domain; Region: TfoX_N; pfam04993 189518004993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518004994 ATP binding site [chemical binding]; other site 189518004995 Mg2+ binding site [ion binding]; other site 189518004996 G-X-G motif; other site 189518004997 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 189518004998 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 189518004999 active site 189518005000 Int/Topo IB signature motif; other site 189518005001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518005002 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189518005003 active site 189518005004 catalytic triad [active] 189518005005 oxyanion hole [active] 189518005006 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518005007 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518005008 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189518005009 active site 189518005010 oxyanion hole [active] 189518005011 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005012 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518005014 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005015 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 189518005016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518005017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189518005018 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 189518005019 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 189518005020 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 189518005021 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 189518005022 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 189518005023 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 189518005024 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 189518005025 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 189518005026 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 189518005027 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 189518005028 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 189518005029 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518005030 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518005031 PGAP1-like protein; Region: PGAP1; pfam07819 189518005032 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 189518005033 substrate binding site [chemical binding]; other site 189518005034 glutamase interaction surface [polypeptide binding]; other site 189518005035 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 189518005036 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 189518005037 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 189518005038 CoA binding domain; Region: CoA_binding; cl17356 189518005039 Bacterial sugar transferase; Region: Bac_transf; pfam02397 189518005040 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 189518005041 Bacitracin resistance protein BacA; Region: BacA; pfam02673 189518005042 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 189518005043 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 189518005044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518005045 ATP binding site [chemical binding]; other site 189518005046 putative Mg++ binding site [ion binding]; other site 189518005047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518005048 nucleotide binding region [chemical binding]; other site 189518005049 ATP-binding site [chemical binding]; other site 189518005050 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 189518005051 Pantoate-beta-alanine ligase; Region: PanC; cd00560 189518005052 active site 189518005053 ATP-binding site [chemical binding]; other site 189518005054 pantoate-binding site; other site 189518005055 HXXH motif; other site 189518005056 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 189518005057 histidinol dehydrogenase; Region: hisD; TIGR00069 189518005058 NAD binding site [chemical binding]; other site 189518005059 dimerization interface [polypeptide binding]; other site 189518005060 product binding site; other site 189518005061 substrate binding site [chemical binding]; other site 189518005062 zinc binding site [ion binding]; other site 189518005063 catalytic residues [active] 189518005064 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 189518005065 putative catalytic site [active] 189518005066 putative metal binding site [ion binding]; other site 189518005067 putative phosphate binding site [ion binding]; other site 189518005068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518005069 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005070 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518005072 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005073 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005074 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189518005075 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518005076 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 189518005077 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 189518005078 MOFRL family; Region: MOFRL; pfam05161 189518005079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005080 active site 189518005081 phosphorylation site [posttranslational modification] 189518005082 intermolecular recognition site; other site 189518005083 dimerization interface [polypeptide binding]; other site 189518005084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005085 metal binding site [ion binding]; metal-binding site 189518005086 active site 189518005087 I-site; other site 189518005088 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 189518005089 dimerization interface [polypeptide binding]; other site 189518005090 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 189518005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005092 active site 189518005093 phosphorylation site [posttranslational modification] 189518005094 intermolecular recognition site; other site 189518005095 PAS domain S-box; Region: sensory_box; TIGR00229 189518005096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005097 putative active site [active] 189518005098 heme pocket [chemical binding]; other site 189518005099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518005100 Histidine kinase; Region: HisKA_2; pfam07568 189518005101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005102 ATP binding site [chemical binding]; other site 189518005103 Mg2+ binding site [ion binding]; other site 189518005104 G-X-G motif; other site 189518005105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518005106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005107 ATP binding site [chemical binding]; other site 189518005108 Mg2+ binding site [ion binding]; other site 189518005109 G-X-G motif; other site 189518005110 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 189518005111 active site 189518005112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518005113 dimerization interface [polypeptide binding]; other site 189518005114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518005115 cyclase homology domain; Region: CHD; cd07302 189518005116 nucleotidyl binding site; other site 189518005117 metal binding site [ion binding]; metal-binding site 189518005118 dimer interface [polypeptide binding]; other site 189518005119 FecR protein; Region: FecR; pfam04773 189518005120 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189518005121 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518005122 ABC transporter; Region: ABC_tran_2; pfam12848 189518005123 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518005124 PAS domain S-box; Region: sensory_box; TIGR00229 189518005125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005126 putative active site [active] 189518005127 heme pocket [chemical binding]; other site 189518005128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005129 PAS fold; Region: PAS_4; pfam08448 189518005130 putative active site [active] 189518005131 heme pocket [chemical binding]; other site 189518005132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518005133 Histidine kinase; Region: HisKA_2; pfam07568 189518005134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005135 ATP binding site [chemical binding]; other site 189518005136 Mg2+ binding site [ion binding]; other site 189518005137 G-X-G motif; other site 189518005138 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518005139 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 189518005140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518005141 dimer interface [polypeptide binding]; other site 189518005142 phosphorylation site [posttranslational modification] 189518005143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005144 ATP binding site [chemical binding]; other site 189518005145 Mg2+ binding site [ion binding]; other site 189518005146 G-X-G motif; other site 189518005147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005148 phosphorylation site [posttranslational modification] 189518005149 intermolecular recognition site; other site 189518005150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518005151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005152 active site 189518005153 phosphorylation site [posttranslational modification] 189518005154 intermolecular recognition site; other site 189518005155 dimerization interface [polypeptide binding]; other site 189518005156 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518005157 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518005158 ligand binding site [chemical binding]; other site 189518005159 flexible hinge region; other site 189518005160 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518005161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518005162 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 189518005163 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 189518005164 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 189518005165 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189518005166 PAS domain S-box; Region: sensory_box; TIGR00229 189518005167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005168 putative active site [active] 189518005169 heme pocket [chemical binding]; other site 189518005170 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518005171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518005172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518005173 dimer interface [polypeptide binding]; other site 189518005174 phosphorylation site [posttranslational modification] 189518005175 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 189518005176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005177 ATP binding site [chemical binding]; other site 189518005178 Mg2+ binding site [ion binding]; other site 189518005179 G-X-G motif; other site 189518005180 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 189518005181 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 189518005182 RNA recognition motif; Region: RRM; smart00360 189518005183 serine/threonine protein kinase; Provisional; Region: PRK11768 189518005184 Phosphotransferase enzyme family; Region: APH; pfam01636 189518005185 Phosphate transporter family; Region: PHO4; cl00396 189518005186 Phosphate transporter family; Region: PHO4; cl00396 189518005187 LXG domain of WXG superfamily; Region: LXG; pfam04740 189518005188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518005189 Coenzyme A binding pocket [chemical binding]; other site 189518005190 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 189518005191 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 189518005192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518005193 Walker A motif; other site 189518005194 ATP binding site [chemical binding]; other site 189518005195 Walker B motif; other site 189518005196 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 189518005197 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 189518005198 oligomer interface [polypeptide binding]; other site 189518005199 active site residues [active] 189518005200 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 189518005201 trigger factor; Region: tig; TIGR00115 189518005202 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 189518005203 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 189518005204 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 189518005205 active site 189518005206 catalytic triad [active] 189518005207 oxyanion hole [active] 189518005208 switch loop; other site 189518005209 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 189518005210 HemN family oxidoreductase; Provisional; Region: PRK05660 189518005211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518005212 FeS/SAM binding site; other site 189518005213 HemN C-terminal domain; Region: HemN_C; pfam06969 189518005214 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518005215 active site 189518005216 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 189518005217 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 189518005218 putative valine binding site [chemical binding]; other site 189518005219 dimer interface [polypeptide binding]; other site 189518005220 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 189518005221 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 189518005222 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 189518005223 PYR/PP interface [polypeptide binding]; other site 189518005224 dimer interface [polypeptide binding]; other site 189518005225 TPP binding site [chemical binding]; other site 189518005226 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 189518005227 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 189518005228 TPP-binding site [chemical binding]; other site 189518005229 dimer interface [polypeptide binding]; other site 189518005230 TPR repeat; Region: TPR_11; pfam13414 189518005231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005232 binding surface 189518005233 TPR motif; other site 189518005234 TPR repeat; Region: TPR_11; pfam13414 189518005235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005236 binding surface 189518005237 TPR motif; other site 189518005238 TPR repeat; Region: TPR_11; pfam13414 189518005239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005240 binding surface 189518005241 TPR motif; other site 189518005242 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518005243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005244 TPR motif; other site 189518005245 binding surface 189518005246 HAMP domain; Region: HAMP; pfam00672 189518005247 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518005248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518005249 dimer interface [polypeptide binding]; other site 189518005250 putative CheW interface [polypeptide binding]; other site 189518005251 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 189518005252 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 189518005253 active site 189518005254 ATP binding site [chemical binding]; other site 189518005255 FeoA domain; Region: FeoA; pfam04023 189518005256 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 189518005257 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 189518005258 G1 box; other site 189518005259 GTP/Mg2+ binding site [chemical binding]; other site 189518005260 Switch I region; other site 189518005261 G2 box; other site 189518005262 G3 box; other site 189518005263 Switch II region; other site 189518005264 G4 box; other site 189518005265 G5 box; other site 189518005266 Nucleoside recognition; Region: Gate; pfam07670 189518005267 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 189518005268 Nucleoside recognition; Region: Gate; pfam07670 189518005269 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 189518005270 Sulfatase; Region: Sulfatase; pfam00884 189518005271 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 189518005272 NeuB family; Region: NeuB; pfam03102 189518005273 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 189518005274 sugar binding site [chemical binding]; other site 189518005275 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518005276 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518005277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518005278 NAD(P) binding site [chemical binding]; other site 189518005279 flagellar assembly protein H; Validated; Region: fliH; PRK06669 189518005280 Flagellar assembly protein FliH; Region: FliH; pfam02108 189518005281 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 189518005282 FliG middle domain; Region: FliG_M; pfam14841 189518005283 FliG C-terminal domain; Region: FliG_C; pfam01706 189518005284 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 189518005285 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 189518005286 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 189518005287 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 189518005288 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 189518005289 Walker A motif; other site 189518005290 ATP binding site [chemical binding]; other site 189518005291 Walker B motif; other site 189518005292 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 189518005293 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 189518005294 TOBE domain; Region: TOBE_2; pfam08402 189518005295 Bacterial SH3 domain; Region: SH3_3; pfam08239 189518005296 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 189518005297 hypothetical protein; Provisional; Region: PRK04323 189518005298 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl17042 189518005299 Jag N-terminus; Region: Jag_N; pfam14804 189518005300 Protein of unknown function (DUF342); Region: DUF342; pfam03961 189518005301 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 189518005302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518005303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518005304 DNA binding residues [nucleotide binding] 189518005305 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 189518005306 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 189518005307 P-loop; other site 189518005308 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12724 189518005309 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 189518005310 FHIPEP family; Region: FHIPEP; pfam00771 189518005311 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12773 189518005312 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 189518005313 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 189518005314 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 189518005315 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 189518005316 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 189518005317 flagellar motor switch protein; Validated; Region: PRK08119 189518005318 flagellar motor switch protein FliN; Region: fliN; TIGR02480 189518005319 Protein of unknown function (DUF971); Region: DUF971; pfam06155 189518005320 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 189518005321 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 189518005322 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189518005323 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189518005324 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189518005325 classical (c) SDRs; Region: SDR_c; cd05233 189518005326 NAD(P) binding site [chemical binding]; other site 189518005327 active site 189518005328 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 189518005329 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 189518005330 C-terminal domain interface [polypeptide binding]; other site 189518005331 GSH binding site (G-site) [chemical binding]; other site 189518005332 dimer interface [polypeptide binding]; other site 189518005333 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 189518005334 putative N-terminal domain interface [polypeptide binding]; other site 189518005335 putative dimer interface [polypeptide binding]; other site 189518005336 putative substrate binding pocket (H-site) [chemical binding]; other site 189518005337 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 189518005338 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 189518005339 active site 189518005340 Zn binding site [ion binding]; other site 189518005341 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 189518005342 putative active site [active] 189518005343 putative catalytic site [active] 189518005344 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189518005345 active site 2 [active] 189518005346 active site 1 [active] 189518005347 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518005348 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 189518005349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 189518005350 NAD(P) binding site [chemical binding]; other site 189518005351 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 189518005352 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 189518005353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 189518005354 PYR/PP interface [polypeptide binding]; other site 189518005355 dimer interface [polypeptide binding]; other site 189518005356 TPP binding site [chemical binding]; other site 189518005357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189518005358 S-adenosylmethionine synthetase; Validated; Region: PRK05250 189518005359 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 189518005360 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 189518005361 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 189518005362 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 189518005363 ParB-like nuclease domain; Region: ParBc; pfam02195 189518005364 Surface lipoprotein of Spirochaetales order; Region: Lipl32; pfam12103 189518005365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518005366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518005367 active site 189518005368 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 189518005369 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 189518005370 N-terminal plug; other site 189518005371 ligand-binding site [chemical binding]; other site 189518005372 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 189518005373 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 189518005374 NAD binding site [chemical binding]; other site 189518005375 active site 189518005376 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 189518005377 cyclase homology domain; Region: CHD; cd07302 189518005378 nucleotidyl binding site; other site 189518005379 metal binding site [ion binding]; metal-binding site 189518005380 dimer interface [polypeptide binding]; other site 189518005381 Protein of unknown function (DUF962); Region: DUF962; pfam06127 189518005382 photolyase PhrII; Region: phr2; TIGR00591 189518005383 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 189518005384 putative transposase OrfB; Reviewed; Region: PHA02517 189518005385 Integrase core domain; Region: rve; pfam00665 189518005386 Integrase core domain; Region: rve_3; pfam13683 189518005387 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 189518005388 oligomerisation interface [polypeptide binding]; other site 189518005389 mobile loop; other site 189518005390 roof hairpin; other site 189518005391 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 189518005392 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 189518005393 ring oligomerisation interface [polypeptide binding]; other site 189518005394 ATP/Mg binding site [chemical binding]; other site 189518005395 stacking interactions; other site 189518005396 hinge regions; other site 189518005397 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 189518005398 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 189518005399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518005400 S-adenosylmethionine binding site [chemical binding]; other site 189518005401 Glycoprotein hormone; Region: Hormone_6; cl02448 189518005402 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518005403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518005404 S-adenosylmethionine binding site [chemical binding]; other site 189518005405 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 189518005406 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 189518005407 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 189518005408 Rod binding protein; Region: Rod-binding; pfam10135 189518005409 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 189518005410 Flagellar L-ring protein; Region: FlgH; cl19182 189518005411 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 189518005412 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 189518005413 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 189518005414 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 189518005415 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 189518005416 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 189518005417 metal binding site [ion binding]; metal-binding site 189518005418 dimer interface [polypeptide binding]; other site 189518005419 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518005420 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518005421 putative transposase OrfB; Reviewed; Region: PHA02517 189518005422 Integrase core domain; Region: rve; pfam00665 189518005423 Integrase core domain; Region: rve_3; pfam13683 189518005424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005425 binding surface 189518005426 TPR motif; other site 189518005427 Restriction endonuclease; Region: Mrr_cat; cl19295 189518005428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 189518005429 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518005430 proline aminopeptidase P II; Provisional; Region: PRK10879 189518005431 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 189518005432 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 189518005433 active site 189518005434 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 189518005435 putative active site [active] 189518005436 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189518005437 active site 189518005438 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 189518005439 Ferritin-like domain; Region: Ferritin; pfam00210 189518005440 heme binding site [chemical binding]; other site 189518005441 ferroxidase pore; other site 189518005442 ferroxidase diiron center [ion binding]; other site 189518005443 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 189518005444 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 189518005445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518005446 acetylglutamate kinase; Provisional; Region: PRK04531 189518005447 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 189518005448 nucleotide binding site [chemical binding]; other site 189518005449 substrate binding site [chemical binding]; other site 189518005450 DUF619 domain of various N-acetylglutamate Synthases (NAGS) of the urea (U) cycle of humans and fish; Region: DUF619-NAGS-U; cd04265 189518005451 Protein of unknown function, DUF393; Region: DUF393; pfam04134 189518005452 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 189518005453 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518005454 KamA family protein; Region: TIGR00238; cl15377 189518005455 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 189518005456 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 189518005457 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 189518005458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189518005459 motif II; other site 189518005460 Sporulation and spore germination; Region: Germane; pfam10646 189518005461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005462 metal binding site [ion binding]; metal-binding site 189518005463 active site 189518005464 I-site; other site 189518005465 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 189518005466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518005467 FeS/SAM binding site; other site 189518005468 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 189518005469 Ligand binding site; other site 189518005470 Putative Catalytic site; other site 189518005471 DXD motif; other site 189518005472 GtrA-like protein; Region: GtrA; pfam04138 189518005473 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 189518005474 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 189518005475 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 189518005476 Cysteine-rich domain; Region: CCG; pfam02754 189518005477 Cysteine-rich domain; Region: CCG; pfam02754 189518005478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518005479 Histidine kinase; Region: HisKA_2; pfam07568 189518005480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005481 ATP binding site [chemical binding]; other site 189518005482 Mg2+ binding site [ion binding]; other site 189518005483 G-X-G motif; other site 189518005484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518005485 Histidine kinase; Region: HisKA_2; pfam07568 189518005486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005487 ATP binding site [chemical binding]; other site 189518005488 Mg2+ binding site [ion binding]; other site 189518005489 G-X-G motif; other site 189518005490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 189518005491 Protein of unknown function (DUF445); Region: DUF445; pfam04286 189518005492 enolase; Provisional; Region: eno; PRK00077 189518005493 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 189518005494 active site 189518005495 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 189518005496 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 189518005497 FMN binding site [chemical binding]; other site 189518005498 substrate binding site [chemical binding]; other site 189518005499 putative catalytic residue [active] 189518005500 Uncharacterized conserved protein [Function unknown]; Region: COG1359 189518005501 Rrf2 family protein; Region: rrf2_super; TIGR00738 189518005502 Transcriptional regulator; Region: Rrf2; pfam02082 189518005503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518005504 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005505 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005506 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 189518005507 Domain of unknown function (DU1801); Region: DUF1801; cl17490 189518005508 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 189518005509 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 189518005510 G1 box; other site 189518005511 putative GEF interaction site [polypeptide binding]; other site 189518005512 GTP/Mg2+ binding site [chemical binding]; other site 189518005513 Switch I region; other site 189518005514 G2 box; other site 189518005515 G3 box; other site 189518005516 Switch II region; other site 189518005517 G4 box; other site 189518005518 G5 box; other site 189518005519 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 189518005520 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 189518005521 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 189518005522 carboxyltransferase (CT) interaction site; other site 189518005523 biotinylation site [posttranslational modification]; other site 189518005524 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 189518005525 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189518005526 ATP-grasp domain; Region: ATP-grasp_4; cl17255 189518005527 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 189518005528 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 189518005529 putative acyl-acceptor binding pocket; other site 189518005530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 189518005531 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 189518005532 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 189518005533 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 189518005534 Alginate export; Region: Alginate_exp; pfam13372 189518005535 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 189518005536 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 189518005537 active site 189518005538 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 189518005539 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 189518005540 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 189518005541 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 189518005542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189518005543 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 189518005544 rod shape-determining protein MreC; Provisional; Region: PRK13922 189518005545 rod shape-determining protein MreB; Provisional; Region: PRK13927 189518005546 MreB and similar proteins; Region: MreB_like; cd10225 189518005547 nucleotide binding site [chemical binding]; other site 189518005548 Mg binding site [ion binding]; other site 189518005549 putative protofilament interaction site [polypeptide binding]; other site 189518005550 RodZ interaction site [polypeptide binding]; other site 189518005551 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 189518005552 exopolyphosphatase; Region: exo_poly_only; TIGR03706 189518005553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 189518005554 A new structural DNA glycosylase; Region: AlkD_like; cl11434 189518005555 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518005556 GAF domain; Region: GAF_3; pfam13492 189518005557 GAF domain; Region: GAF; pfam01590 189518005558 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 189518005559 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 189518005560 SLBB domain; Region: SLBB; pfam10531 189518005561 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444 189518005562 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 189518005563 gamma subunit interface [polypeptide binding]; other site 189518005564 epsilon subunit interface [polypeptide binding]; other site 189518005565 LBP interface [polypeptide binding]; other site 189518005566 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 189518005567 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 189518005568 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 189518005569 alpha subunit interaction interface [polypeptide binding]; other site 189518005570 Walker A motif; other site 189518005571 ATP binding site [chemical binding]; other site 189518005572 Walker B motif; other site 189518005573 inhibitor binding site; inhibition site 189518005574 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 189518005575 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 189518005576 core domain interface [polypeptide binding]; other site 189518005577 delta subunit interface [polypeptide binding]; other site 189518005578 epsilon subunit interface [polypeptide binding]; other site 189518005579 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 189518005580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 189518005581 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 189518005582 beta subunit interaction interface [polypeptide binding]; other site 189518005583 Walker A motif; other site 189518005584 ATP binding site [chemical binding]; other site 189518005585 Walker B motif; other site 189518005586 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 189518005587 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13434 189518005588 F0F1 ATP synthase subunit B; Provisional; Region: PRK13460 189518005589 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 189518005590 F0F1 ATP synthase subunit A; Provisional; Region: PRK13417 189518005591 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 189518005592 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 189518005593 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 189518005594 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 189518005595 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 189518005596 Catalytic site [active] 189518005597 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 189518005598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518005599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518005600 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 189518005601 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 189518005602 oligomer interface [polypeptide binding]; other site 189518005603 metal binding site [ion binding]; metal-binding site 189518005604 metal binding site [ion binding]; metal-binding site 189518005605 putative Cl binding site [ion binding]; other site 189518005606 aspartate ring; other site 189518005607 basic sphincter; other site 189518005608 hydrophobic gate; other site 189518005609 periplasmic entrance; other site 189518005610 FecR protein; Region: FecR; pfam04773 189518005611 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 189518005612 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 189518005613 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 189518005614 TPR repeat; Region: TPR_11; pfam13414 189518005615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005616 binding surface 189518005617 TPR motif; other site 189518005618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518005619 binding surface 189518005620 TPR repeat; Region: TPR_11; pfam13414 189518005621 TPR motif; other site 189518005622 TPR repeat; Region: TPR_11; pfam13414 189518005623 PAS domain S-box; Region: sensory_box; TIGR00229 189518005624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005625 putative active site [active] 189518005626 heme pocket [chemical binding]; other site 189518005627 PAS domain S-box; Region: sensory_box; TIGR00229 189518005628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005629 putative active site [active] 189518005630 heme pocket [chemical binding]; other site 189518005631 PAS domain S-box; Region: sensory_box; TIGR00229 189518005632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005633 putative active site [active] 189518005634 heme pocket [chemical binding]; other site 189518005635 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005636 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518005637 putative active site [active] 189518005638 heme pocket [chemical binding]; other site 189518005639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005640 putative active site [active] 189518005641 heme pocket [chemical binding]; other site 189518005642 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189518005643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518005644 dimer interface [polypeptide binding]; other site 189518005645 phosphorylation site [posttranslational modification] 189518005646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005647 ATP binding site [chemical binding]; other site 189518005648 Mg2+ binding site [ion binding]; other site 189518005649 G-X-G motif; other site 189518005650 FeS assembly protein SufB; Region: sufB; TIGR01980 189518005651 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 189518005652 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 189518005653 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 189518005654 dimer interface [polypeptide binding]; other site 189518005655 decamer (pentamer of dimers) interface [polypeptide binding]; other site 189518005656 catalytic triad [active] 189518005657 peroxidatic and resolving cysteines [active] 189518005658 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 189518005659 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518005660 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518005661 dimer interface [polypeptide binding]; other site 189518005662 putative CheW interface [polypeptide binding]; other site 189518005663 Planctomycete cytochrome C; Region: PSCyt1; cl19300 189518005664 YceI-like domain; Region: YceI; pfam04264 189518005665 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189518005666 CoenzymeA binding site [chemical binding]; other site 189518005667 subunit interaction site [polypeptide binding]; other site 189518005668 PHB binding site; other site 189518005669 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 189518005670 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518005671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005672 active site 189518005673 phosphorylation site [posttranslational modification] 189518005674 intermolecular recognition site; other site 189518005675 dimerization interface [polypeptide binding]; other site 189518005676 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518005677 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 189518005678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518005679 active site 189518005680 phosphorylation site [posttranslational modification] 189518005681 intermolecular recognition site; other site 189518005682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518005683 dimer interface [polypeptide binding]; other site 189518005684 phosphorylation site [posttranslational modification] 189518005685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005686 ATP binding site [chemical binding]; other site 189518005687 Mg2+ binding site [ion binding]; other site 189518005688 G-X-G motif; other site 189518005689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518005690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005691 active site 189518005692 phosphorylation site [posttranslational modification] 189518005693 intermolecular recognition site; other site 189518005694 dimerization interface [polypeptide binding]; other site 189518005695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005696 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 189518005697 putative active site [active] 189518005698 heme pocket [chemical binding]; other site 189518005699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518005700 dimer interface [polypeptide binding]; other site 189518005701 phosphorylation site [posttranslational modification] 189518005702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518005703 ATP binding site [chemical binding]; other site 189518005704 Mg2+ binding site [ion binding]; other site 189518005705 G-X-G motif; other site 189518005706 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518005707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005708 putative active site [active] 189518005709 heme pocket [chemical binding]; other site 189518005710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005711 putative active site [active] 189518005712 heme pocket [chemical binding]; other site 189518005713 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518005714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518005715 ligand binding site [chemical binding]; other site 189518005716 flexible hinge region; other site 189518005717 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 189518005718 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 189518005719 active site 189518005720 nucleophile elbow; other site 189518005721 GAF domain; Region: GAF; pfam01590 189518005722 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518005723 cyclase homology domain; Region: CHD; cd07302 189518005724 nucleotidyl binding site; other site 189518005725 metal binding site [ion binding]; metal-binding site 189518005726 dimer interface [polypeptide binding]; other site 189518005727 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 189518005728 ornithine carbamoyltransferase; Provisional; Region: PRK14804 189518005729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 189518005730 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 189518005731 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 189518005732 PemK-like protein; Region: PemK; pfam02452 189518005733 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 189518005734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189518005735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518005736 non-specific DNA binding site [nucleotide binding]; other site 189518005737 salt bridge; other site 189518005738 sequence-specific DNA binding site [nucleotide binding]; other site 189518005739 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189518005740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 189518005741 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518005742 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 189518005743 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 189518005744 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 189518005745 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 189518005746 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 189518005747 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 189518005748 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 189518005749 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 189518005750 Putative Ig domain; Region: He_PIG; pfam05345 189518005751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518005752 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 189518005753 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518005754 catalytic site [active] 189518005755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518005756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005757 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005758 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 189518005759 active site 189518005760 catalytic triad [active] 189518005761 dimer interface [polypeptide binding]; other site 189518005762 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518005763 Leucine rich repeat; Region: LRR_8; pfam13855 189518005764 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518005765 Leucine-rich repeats; other site 189518005766 Leucine rich repeat; Region: LRR_8; pfam13855 189518005767 Leucine rich repeat; Region: LRR_8; pfam13855 189518005768 Leucine rich repeat; Region: LRR_8; pfam13855 189518005769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 189518005770 active site residue [active] 189518005771 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 189518005772 Initiation factor 2 subunit family; Region: IF-2B; cl00348 189518005773 Protein of unknown function (DUF342); Region: DUF342; pfam03961 189518005774 Predicted esterase [General function prediction only]; Region: COG0400 189518005775 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 189518005776 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 189518005777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518005778 S-adenosylmethionine binding site [chemical binding]; other site 189518005779 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 189518005780 active site 189518005781 NTP binding site [chemical binding]; other site 189518005782 metal binding triad [ion binding]; metal-binding site 189518005783 antibiotic binding site [chemical binding]; other site 189518005784 HEPN domain; Region: HEPN; pfam05168 189518005785 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 189518005786 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 189518005787 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 189518005788 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 189518005789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518005790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189518005791 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 189518005792 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 189518005793 metal binding site 2 [ion binding]; metal-binding site 189518005794 putative DNA binding helix; other site 189518005795 structural Zn2+ binding site [ion binding]; other site 189518005796 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 189518005797 transmembrane helices; other site 189518005798 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 189518005799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 189518005800 non-specific DNA binding site [nucleotide binding]; other site 189518005801 salt bridge; other site 189518005802 sequence-specific DNA binding site [nucleotide binding]; other site 189518005803 Cupin domain; Region: Cupin_2; pfam07883 189518005804 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 189518005805 active site 189518005806 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 189518005807 active site 189518005808 homodimer interface [polypeptide binding]; other site 189518005809 SAM binding site [chemical binding]; other site 189518005810 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 189518005811 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 189518005812 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518005813 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518005814 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 189518005815 RuvA N terminal domain; Region: RuvA_N; pfam01330 189518005816 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 189518005817 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 189518005818 Predicted transcriptional regulator [Transcription]; Region: COG2378 189518005819 HTH domain; Region: HTH_11; pfam08279 189518005820 WYL domain; Region: WYL; pfam13280 189518005821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518005822 NAD(P) binding site [chemical binding]; other site 189518005823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518005824 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 189518005825 active site 189518005826 potential frameshift: common BLAST hit: gi|24213007|ref|NP_710488.1| transposase 189518005827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518005828 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518005829 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005830 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518005831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518005832 Zn2+ binding site [ion binding]; other site 189518005833 Mg2+ binding site [ion binding]; other site 189518005834 DNA repair protein RadA; Provisional; Region: PRK11823 189518005835 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 189518005836 Walker A motif; other site 189518005837 ATP binding site [chemical binding]; other site 189518005838 Walker B motif; other site 189518005839 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 189518005840 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 189518005841 catalytic site [active] 189518005842 putative active site [active] 189518005843 putative substrate binding site [chemical binding]; other site 189518005844 probable galactinol--sucrose galactosyltransferase 2; Region: PLN02219 189518005845 Melibiase; Region: Melibiase; pfam02065 189518005846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005847 active site 189518005848 phosphorylation site [posttranslational modification] 189518005849 intermolecular recognition site; other site 189518005850 dimerization interface [polypeptide binding]; other site 189518005851 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518005852 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 189518005853 putative active site [active] 189518005854 Zn binding site [ion binding]; other site 189518005855 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 189518005856 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 189518005857 domain interfaces; other site 189518005858 active site 189518005859 PAS domain S-box; Region: sensory_box; TIGR00229 189518005860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005861 putative active site [active] 189518005862 heme pocket [chemical binding]; other site 189518005863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005864 metal binding site [ion binding]; metal-binding site 189518005865 active site 189518005866 I-site; other site 189518005867 PAS domain S-box; Region: sensory_box; TIGR00229 189518005868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005869 putative active site [active] 189518005870 heme pocket [chemical binding]; other site 189518005871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005872 metal binding site [ion binding]; metal-binding site 189518005873 active site 189518005874 I-site; other site 189518005875 PAS domain S-box; Region: sensory_box; TIGR00229 189518005876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005877 putative active site [active] 189518005878 heme pocket [chemical binding]; other site 189518005879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005880 metal binding site [ion binding]; metal-binding site 189518005881 active site 189518005882 I-site; other site 189518005883 PAS domain S-box; Region: sensory_box; TIGR00229 189518005884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005885 putative active site [active] 189518005886 heme pocket [chemical binding]; other site 189518005887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005888 metal binding site [ion binding]; metal-binding site 189518005889 active site 189518005890 I-site; other site 189518005891 PAS domain S-box; Region: sensory_box; TIGR00229 189518005892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005893 putative active site [active] 189518005894 heme pocket [chemical binding]; other site 189518005895 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005896 metal binding site [ion binding]; metal-binding site 189518005897 active site 189518005898 I-site; other site 189518005899 PAS domain S-box; Region: sensory_box; TIGR00229 189518005900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005901 putative active site [active] 189518005902 heme pocket [chemical binding]; other site 189518005903 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005904 metal binding site [ion binding]; metal-binding site 189518005905 active site 189518005906 I-site; other site 189518005907 PAS domain S-box; Region: sensory_box; TIGR00229 189518005908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518005909 putative active site [active] 189518005910 heme pocket [chemical binding]; other site 189518005911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518005912 metal binding site [ion binding]; metal-binding site 189518005913 active site 189518005914 I-site; other site 189518005915 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 189518005916 Cl- selectivity filter; other site 189518005917 Cl- binding residues [ion binding]; other site 189518005918 pore gating glutamate residue; other site 189518005919 dimer interface [polypeptide binding]; other site 189518005920 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 189518005921 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 189518005922 dimerization interface [polypeptide binding]; other site 189518005923 putative ATP binding site [chemical binding]; other site 189518005924 FecR protein; Region: FecR; pfam04773 189518005925 Bor protein; Region: Lambda_Bor; pfam06291 189518005926 Kelch domain; Region: Kelch; smart00612 189518005927 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189518005928 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189518005929 Kelch domain; Region: Kelch; smart00612 189518005930 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 189518005931 Protein of unknown function, DUF393; Region: DUF393; cl01136 189518005932 alpha-glucosidase; Provisional; Region: PRK10426 189518005933 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 189518005934 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 189518005935 putative active site [active] 189518005936 putative catalytic site [active] 189518005937 Rhodanese Homology Domain; Region: RHOD; smart00450 189518005938 active site residue [active] 189518005939 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 189518005940 active site residue [active] 189518005941 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189518005942 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189518005943 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189518005944 protein binding site [polypeptide binding]; other site 189518005945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518005946 active site 189518005947 phosphorylation site [posttranslational modification] 189518005948 intermolecular recognition site; other site 189518005949 dimerization interface [polypeptide binding]; other site 189518005950 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189518005951 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 189518005952 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 189518005953 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 189518005954 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 189518005955 active site 189518005956 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 189518005957 putative acyl-acceptor binding pocket; other site 189518005958 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 189518005959 B12 binding site [chemical binding]; other site 189518005960 cobalt ligand [ion binding]; other site 189518005961 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 189518005962 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189518005963 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 189518005964 putative active site [active] 189518005965 putative substrate binding site [chemical binding]; other site 189518005966 putative coenzyme B12 binding site [chemical binding]; other site 189518005967 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 189518005968 active site 189518005969 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 189518005970 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518005971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518005972 nucleophilic elbow; other site 189518005973 catalytic triad; other site 189518005974 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 189518005975 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 189518005976 Leucine rich repeat; Region: LRR_8; pfam13855 189518005977 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518005978 Leucine-rich repeats; other site 189518005979 Substrate binding site [chemical binding]; other site 189518005980 Leucine rich repeat; Region: LRR_8; pfam13855 189518005981 Leucine rich repeat; Region: LRR_8; pfam13855 189518005982 Leucine rich repeat; Region: LRR_8; pfam13855 189518005983 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518005984 Leucine rich repeat; Region: LRR_8; pfam13855 189518005985 Leucine rich repeat; Region: LRR_8; pfam13855 189518005986 Leucine rich repeat; Region: LRR_8; pfam13855 189518005987 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518005988 Leucine rich repeat; Region: LRR_8; pfam13855 189518005989 Leucine-rich repeats; other site 189518005990 Substrate binding site [chemical binding]; other site 189518005991 Leucine rich repeat; Region: LRR_8; pfam13855 189518005992 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518005993 Leucine rich repeat; Region: LRR_8; pfam13855 189518005994 YCII-related domain; Region: YCII; cl00999 189518005995 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518005996 cyclase homology domain; Region: CHD; cd07302 189518005997 nucleotidyl binding site; other site 189518005998 metal binding site [ion binding]; metal-binding site 189518005999 dimer interface [polypeptide binding]; other site 189518006000 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 189518006001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518006002 active site 189518006003 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 189518006004 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 189518006005 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 189518006006 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 189518006007 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 189518006008 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 189518006009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518006010 S-adenosylmethionine binding site [chemical binding]; other site 189518006011 Stage II sporulation protein; Region: SpoIID; pfam08486 189518006012 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 189518006013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 189518006014 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189518006015 Walker A/P-loop; other site 189518006016 ATP binding site [chemical binding]; other site 189518006017 Q-loop/lid; other site 189518006018 ABC transporter signature motif; other site 189518006019 Walker B; other site 189518006020 D-loop; other site 189518006021 H-loop/switch region; other site 189518006022 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 189518006023 FtsX-like permease family; Region: FtsX; pfam02687 189518006024 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 189518006025 FtsX-like permease family; Region: FtsX; pfam02687 189518006026 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518006027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189518006028 active site 189518006029 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 189518006030 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 189518006031 multimer interface [polypeptide binding]; other site 189518006032 active site 189518006033 catalytic triad [active] 189518006034 protein interface 1 [polypeptide binding]; other site 189518006035 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 189518006036 homodimer interface [polypeptide binding]; other site 189518006037 NAD binding pocket [chemical binding]; other site 189518006038 ATP binding pocket [chemical binding]; other site 189518006039 Mg binding site [ion binding]; other site 189518006040 active-site loop [active] 189518006041 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 189518006042 putative SAM binding site [chemical binding]; other site 189518006043 putative homodimer interface [polypeptide binding]; other site 189518006044 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 189518006045 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 189518006046 active site 189518006047 NAD binding site [chemical binding]; other site 189518006048 metal binding site [ion binding]; metal-binding site 189518006049 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 189518006050 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 189518006051 active site 189518006052 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 189518006053 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 189518006054 DHH family; Region: DHH; pfam01368 189518006055 DHHA1 domain; Region: DHHA1; pfam02272 189518006056 poly(A) polymerase; Region: pcnB; TIGR01942 189518006057 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 189518006058 active site 189518006059 NTP binding site [chemical binding]; other site 189518006060 metal binding triad [ion binding]; metal-binding site 189518006061 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 189518006062 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518006063 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518006064 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 189518006065 Methyltransferase domain; Region: Methyltransf_18; pfam12847 189518006066 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 189518006067 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 189518006068 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 189518006069 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 189518006070 Domain of unknown function (DUF389); Region: DUF389; pfam04087 189518006071 putative single-stranded DNA-binding protein; Region: PHA01740 189518006072 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 189518006073 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 189518006074 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 189518006075 YjbR; Region: YjbR; pfam04237 189518006076 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 189518006077 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 189518006078 CARDB; Region: CARDB; pfam07705 189518006079 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 189518006080 Leucine rich repeat; Region: LRR_8; pfam13855 189518006081 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518006082 Leucine-rich repeats; other site 189518006083 Substrate binding site [chemical binding]; other site 189518006084 Leucine rich repeat; Region: LRR_8; pfam13855 189518006085 Leucine rich repeat; Region: LRR_8; pfam13855 189518006086 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518006087 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518006088 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518006089 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 189518006090 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 189518006091 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 189518006092 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 189518006093 Bacterial SH3 domain; Region: SH3_3; pfam08239 189518006094 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 189518006095 cyclase homology domain; Region: CHD; cd07302 189518006096 nucleotidyl binding site; other site 189518006097 metal binding site [ion binding]; metal-binding site 189518006098 dimer interface [polypeptide binding]; other site 189518006099 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518006100 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518006101 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 189518006102 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 189518006103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518006104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518006105 homodimer interface [polypeptide binding]; other site 189518006106 catalytic residue [active] 189518006107 Trypsin; Region: Trypsin; pfam00089 189518006108 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189518006109 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189518006110 protein binding site [polypeptide binding]; other site 189518006111 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 189518006112 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 189518006113 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 189518006114 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 189518006115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006116 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006117 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 189518006118 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 189518006119 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 189518006120 TPR repeat; Region: TPR_11; pfam13414 189518006121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518006122 TPR motif; other site 189518006123 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 189518006124 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518006125 anti sigma factor interaction site; other site 189518006126 regulatory phosphorylation site [posttranslational modification]; other site 189518006127 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 189518006128 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 189518006129 Ligand binding site; other site 189518006130 Putative Catalytic site; other site 189518006131 DXD motif; other site 189518006132 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 189518006133 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006134 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006135 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006136 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006137 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 189518006138 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006139 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006140 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006141 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518006142 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 189518006143 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 189518006144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518006145 NAD(P) binding site [chemical binding]; other site 189518006146 active site 189518006147 adenylosuccinate lyase; Provisional; Region: PRK07492 189518006148 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 189518006149 tetramer interface [polypeptide binding]; other site 189518006150 active site 189518006151 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 189518006152 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 189518006153 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 189518006154 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 189518006155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518006156 Zn2+ binding site [ion binding]; other site 189518006157 Mg2+ binding site [ion binding]; other site 189518006158 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 189518006159 synthetase active site [active] 189518006160 NTP binding site [chemical binding]; other site 189518006161 metal binding site [ion binding]; metal-binding site 189518006162 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 189518006163 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 189518006164 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 189518006165 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 189518006166 dimerization interface [polypeptide binding]; other site 189518006167 active site 189518006168 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518006169 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518006170 Lipopolysaccharide-assembly; Region: LptE; cl01125 189518006171 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 189518006172 metal binding site 2 [ion binding]; metal-binding site 189518006173 putative DNA binding helix; other site 189518006174 metal binding site 1 [ion binding]; metal-binding site 189518006175 dimer interface [polypeptide binding]; other site 189518006176 structural Zn2+ binding site [ion binding]; other site 189518006177 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 189518006178 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 189518006179 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518006180 anti sigma factor interaction site; other site 189518006181 regulatory phosphorylation site [posttranslational modification]; other site 189518006182 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 189518006183 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518006184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006185 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006186 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006188 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518006189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518006190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518006191 S-adenosylmethionine binding site [chemical binding]; other site 189518006192 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 189518006193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518006194 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518006195 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518006196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518006197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518006198 active site 189518006199 phosphorylation site [posttranslational modification] 189518006200 intermolecular recognition site; other site 189518006201 dimerization interface [polypeptide binding]; other site 189518006202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189518006203 DNA binding site [nucleotide binding] 189518006204 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 189518006205 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 189518006206 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 189518006207 Ligand Binding Site [chemical binding]; other site 189518006208 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 189518006209 GAF domain; Region: GAF_3; pfam13492 189518006210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518006211 dimer interface [polypeptide binding]; other site 189518006212 phosphorylation site [posttranslational modification] 189518006213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518006214 ATP binding site [chemical binding]; other site 189518006215 Mg2+ binding site [ion binding]; other site 189518006216 G-X-G motif; other site 189518006217 K+-transporting ATPase, c chain; Region: KdpC; cl00944 189518006218 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 189518006219 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 189518006220 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 189518006221 Soluble P-type ATPase [General function prediction only]; Region: COG4087 189518006222 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 189518006223 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 189518006224 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 189518006225 activation loop (A-loop); other site 189518006226 AAA ATPase domain; Region: AAA_16; pfam13191 189518006227 Predicted ATPase [General function prediction only]; Region: COG3899 189518006228 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 189518006229 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518006230 Uncharacterized conserved protein [Function unknown]; Region: COG3349 189518006231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189518006232 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 189518006233 Immunity protein 25; Region: Imm25; pfam15571 189518006234 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 189518006235 Uncharacterized conserved protein [Function unknown]; Region: COG1262 189518006236 Zinc carboxypeptidase; Region: Peptidase_M14; pfam00246 189518006237 active site 189518006238 Zn binding site [ion binding]; other site 189518006239 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 189518006240 EamA-like transporter family; Region: EamA; pfam00892 189518006241 EamA-like transporter family; Region: EamA; pfam00892 189518006242 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 189518006243 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 189518006244 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 189518006245 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 189518006246 active site residue [active] 189518006247 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518006248 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 189518006249 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 189518006250 dimer interface [polypeptide binding]; other site 189518006251 active site 189518006252 Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389 189518006253 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 189518006254 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 189518006255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518006256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518006257 active site 189518006258 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 189518006259 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 189518006260 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 189518006261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518006262 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518006263 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 189518006264 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 189518006265 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 189518006266 N-terminal plug; other site 189518006267 ligand-binding site [chemical binding]; other site 189518006268 putative DNA polymerase catalytic subunit; Provisional; Region: PHA03334 189518006269 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518006270 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 189518006271 DDE superfamily endonuclease; Region: DDE_Tnp_4; pfam13359 189518006272 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 189518006273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518006274 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 189518006275 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189518006276 putative NAD(P) binding site [chemical binding]; other site 189518006277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 189518006278 GcpE protein; Region: GcpE; pfam04551 189518006279 GcpE protein; Region: GcpE; cl19500 189518006280 MORN repeat; Region: MORN; cl14787 189518006281 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 189518006282 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 189518006283 putative active site [active] 189518006284 putative metal binding site [ion binding]; other site 189518006285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006286 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006287 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006288 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189518006289 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189518006290 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 189518006291 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518006292 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189518006293 active site 189518006294 catalytic tetrad [active] 189518006295 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 189518006296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518006297 ABC transporter; Region: ABC_tran_2; pfam12848 189518006298 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518006299 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 189518006300 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 189518006301 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 189518006302 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 189518006303 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 189518006304 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 189518006305 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 189518006306 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09713 189518006307 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cd09714 189518006308 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 189518006309 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688 189518006310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006311 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006312 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006313 Uncharacterized conserved protein [Function unknown]; Region: COG4933 189518006314 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 189518006315 HsdM N-terminal domain; Region: HsdM_N; pfam12161 189518006316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518006317 S-adenosylmethionine binding site [chemical binding]; other site 189518006318 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 189518006319 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 189518006320 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 189518006321 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 189518006322 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 189518006323 Pectinacetylesterase; Region: PAE; pfam03283 189518006324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 189518006325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518006326 active site 189518006327 phosphorylation site [posttranslational modification] 189518006328 intermolecular recognition site; other site 189518006329 dimerization interface [polypeptide binding]; other site 189518006330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518006331 dimerization interface [polypeptide binding]; other site 189518006332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518006333 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518006334 putative active site [active] 189518006335 heme pocket [chemical binding]; other site 189518006336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518006337 putative active site [active] 189518006338 heme pocket [chemical binding]; other site 189518006339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518006340 dimer interface [polypeptide binding]; other site 189518006341 phosphorylation site [posttranslational modification] 189518006342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518006343 ATP binding site [chemical binding]; other site 189518006344 Mg2+ binding site [ion binding]; other site 189518006345 G-X-G motif; other site 189518006346 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 189518006347 putative hydrophobic ligand binding site [chemical binding]; other site 189518006348 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 189518006349 substrate binding pocket [chemical binding]; other site 189518006350 chain length determination region; other site 189518006351 substrate-Mg2+ binding site; other site 189518006352 catalytic residues [active] 189518006353 aspartate-rich region 1; other site 189518006354 active site lid residues [active] 189518006355 aspartate-rich region 2; other site 189518006356 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 189518006357 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 189518006358 TPP-binding site [chemical binding]; other site 189518006359 dimer interface [polypeptide binding]; other site 189518006360 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 189518006361 FecR protein; Region: FecR; pfam04773 189518006362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518006363 dimerization interface [polypeptide binding]; other site 189518006364 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518006365 cyclase homology domain; Region: CHD; cd07302 189518006366 nucleotidyl binding site; other site 189518006367 metal binding site [ion binding]; metal-binding site 189518006368 dimer interface [polypeptide binding]; other site 189518006369 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 189518006370 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 189518006371 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518006372 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518006373 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 189518006374 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 189518006375 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 189518006376 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 189518006377 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 189518006378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006379 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006380 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006382 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006384 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006385 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 189518006386 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518006387 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 189518006388 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 189518006389 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 189518006390 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 189518006391 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 189518006392 The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764 189518006393 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 189518006394 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 189518006395 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 189518006396 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 189518006397 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 189518006398 heme-binding residues [chemical binding]; other site 189518006399 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 189518006400 putative catalytic site [active] 189518006401 putative metal binding site [ion binding]; other site 189518006402 putative phosphate binding site [ion binding]; other site 189518006403 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518006404 Beta-propeller repeat; Region: SBBP; pfam06739 189518006405 Beta-propeller repeat; Region: SBBP; pfam06739 189518006406 Beta-propeller repeat; Region: SBBP; pfam06739 189518006407 Beta-propeller repeat; Region: SBBP; pfam06739 189518006408 Beta-propeller repeat; Region: SBBP; pfam06739 189518006409 Beta-propeller repeat; Region: SBBP; pfam06739 189518006410 Beta-propeller repeat; Region: SBBP; pfam06739 189518006411 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 189518006412 putative active site [active] 189518006413 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 189518006414 Uncharacterized conserved protein [Function unknown]; Region: COG1262 189518006415 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006417 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518006420 binding surface 189518006421 TPR motif; other site 189518006422 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 189518006423 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 189518006424 TPP-binding site; other site 189518006425 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 189518006426 PYR/PP interface [polypeptide binding]; other site 189518006427 dimer interface [polypeptide binding]; other site 189518006428 TPP binding site [chemical binding]; other site 189518006429 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 189518006430 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 189518006431 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518006432 cyclase homology domain; Region: CHD; cd07302 189518006433 nucleotidyl binding site; other site 189518006434 metal binding site [ion binding]; metal-binding site 189518006435 dimer interface [polypeptide binding]; other site 189518006436 potential protein location (hypothetical protein) that overlaps protein (adenylate cyclase related protein) 189518006437 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518006438 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 189518006439 substrate binding site [chemical binding]; other site 189518006440 active site 189518006441 catalytic residues [active] 189518006442 heterodimer interface [polypeptide binding]; other site 189518006443 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 189518006444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518006445 catalytic residue [active] 189518006446 prolyl-tRNA synthetase; Provisional; Region: PRK09194 189518006447 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 189518006448 dimer interface [polypeptide binding]; other site 189518006449 motif 1; other site 189518006450 active site 189518006451 motif 2; other site 189518006452 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 189518006453 putative deacylase active site [active] 189518006454 motif 3; other site 189518006455 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 189518006456 anticodon binding site; other site 189518006457 RIP metalloprotease RseP; Region: TIGR00054 189518006458 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 189518006459 active site 189518006460 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 189518006461 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 189518006462 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 189518006463 putative substrate binding region [chemical binding]; other site 189518006464 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 189518006465 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 189518006466 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 189518006467 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 189518006468 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 189518006469 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 189518006470 active site 189518006471 dimer interface [polypeptide binding]; other site 189518006472 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 189518006473 hinge region; other site 189518006474 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 189518006475 putative nucleotide binding site [chemical binding]; other site 189518006476 uridine monophosphate binding site [chemical binding]; other site 189518006477 homohexameric interface [polypeptide binding]; other site 189518006478 elongation factor Ts; Reviewed; Region: tsf; PRK12332 189518006479 UBA/TS-N domain; Region: UBA; pfam00627 189518006480 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 189518006481 rRNA interaction site [nucleotide binding]; other site 189518006482 S8 interaction site; other site 189518006483 putative laminin-1 binding site; other site 189518006484 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 189518006485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518006486 TPR repeat; Region: TPR_11; pfam13414 189518006487 binding surface 189518006488 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 189518006489 YbbR-like protein; Region: YbbR; pfam07949 189518006490 Uncharacterized conserved protein [Function unknown]; Region: COG1624 189518006491 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 189518006492 dihydrodipicolinate reductase; Provisional; Region: PRK00048 189518006493 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 189518006494 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 189518006495 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 189518006496 dimer interface [polypeptide binding]; other site 189518006497 active site 189518006498 catalytic residue [active] 189518006499 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 189518006500 Mg++ binding site [ion binding]; other site 189518006501 putative catalytic motif [active] 189518006502 putative substrate binding site [chemical binding]; other site 189518006503 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 189518006504 active site 189518006505 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 189518006506 TIGR01777 family protein; Region: yfcH 189518006507 putative NAD(P) binding site [chemical binding]; other site 189518006508 putative active site [active] 189518006509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 189518006510 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189518006511 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 189518006512 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 189518006513 dimer interface [polypeptide binding]; other site 189518006514 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518006515 Leucine-rich repeats; other site 189518006516 Leucine rich repeat; Region: LRR_8; pfam13855 189518006517 Substrate binding site [chemical binding]; other site 189518006518 Leucine rich repeat; Region: LRR_8; pfam13855 189518006519 Leucine rich repeat; Region: LRR_8; pfam13855 189518006520 Leucine rich repeat; Region: LRR_8; pfam13855 189518006521 Leucine rich repeat; Region: LRR_8; pfam13855 189518006522 Leucine-rich repeats; other site 189518006523 Substrate binding site [chemical binding]; other site 189518006524 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 189518006525 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518006526 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518006527 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518006528 Leucine-rich repeats; other site 189518006529 Substrate binding site [chemical binding]; other site 189518006530 Leucine rich repeat; Region: LRR_8; pfam13855 189518006531 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518006532 Substrate binding site [chemical binding]; other site 189518006533 Leucine rich repeat; Region: LRR_8; pfam13855 189518006534 Leucine rich repeat; Region: LRR_8; pfam13855 189518006535 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518006536 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518006537 Leucine rich repeat; Region: LRR_8; pfam13855 189518006538 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518006539 Leucine rich repeat; Region: LRR_8; pfam13855 189518006540 Leucine-rich repeats; other site 189518006541 Substrate binding site [chemical binding]; other site 189518006542 Leucine rich repeat; Region: LRR_8; pfam13855 189518006543 Leucine rich repeat; Region: LRR_8; pfam13855 189518006544 Leucine rich repeat; Region: LRR_8; pfam13855 189518006545 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 189518006546 Leucine-rich repeats; other site 189518006547 Substrate binding site [chemical binding]; other site 189518006548 Leucine rich repeat; Region: LRR_8; pfam13855 189518006549 Leucine rich repeat; Region: LRR_8; pfam13855 189518006550 Leucine rich repeat; Region: LRR_8; pfam13855 189518006551 Leucine rich repeat; Region: LRR_8; pfam13855 189518006552 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518006553 putative transposase OrfB; Reviewed; Region: PHA02517 189518006554 Integrase core domain; Region: rve; pfam00665 189518006555 Integrase core domain; Region: rve_3; pfam13683 189518006556 Kelch domain; Region: Kelch; smart00612 189518006557 DNA packaging tegument protein UL25; Provisional; Region: PHA03248 189518006558 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 189518006559 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518006560 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518006561 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 189518006562 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 189518006563 RHS Repeat; Region: RHS_repeat; pfam05593 189518006564 RHS Repeat; Region: RHS_repeat; pfam05593 189518006565 RHS Repeat; Region: RHS_repeat; pfam05593 189518006566 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 189518006567 Kelch motif; Region: Kelch_1; pfam01344 189518006568 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518006569 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 189518006570 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 189518006571 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 189518006572 catalytic residues [active] 189518006573 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 189518006574 putative active site [active] 189518006575 CcmE; Region: CcmE; cl00994 189518006576 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 189518006577 Cytochrome C biogenesis protein; Region: CcmH; cl01179 189518006578 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 189518006579 Double zinc ribbon; Region: DZR; pfam12773 189518006580 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 189518006581 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 189518006582 putative NAD(P) binding site [chemical binding]; other site 189518006583 catalytic Zn binding site [ion binding]; other site 189518006584 structural Zn binding site [ion binding]; other site 189518006585 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189518006586 CoenzymeA binding site [chemical binding]; other site 189518006587 subunit interaction site [polypeptide binding]; other site 189518006588 PHB binding site; other site 189518006589 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 189518006590 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 189518006591 C-terminal domain interface [polypeptide binding]; other site 189518006592 GSH binding site (G-site) [chemical binding]; other site 189518006593 dimer interface [polypeptide binding]; other site 189518006594 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 189518006595 N-terminal domain interface [polypeptide binding]; other site 189518006596 putative dimer interface [polypeptide binding]; other site 189518006597 active site 189518006598 potential protein location (hypothetical protein) that overlaps protein (glutathione transferase) 189518006599 Acyltransferase family; Region: Acyl_transf_3; cl19154 189518006600 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 189518006601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518006602 dimer interface [polypeptide binding]; other site 189518006603 phosphorylation site [posttranslational modification] 189518006604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518006605 ATP binding site [chemical binding]; other site 189518006606 Mg2+ binding site [ion binding]; other site 189518006607 G-X-G motif; other site 189518006608 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518006609 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 189518006610 catalytic core [active] 189518006611 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 189518006612 putative active site [active] 189518006613 putative substrate binding site [chemical binding]; other site 189518006614 ATP binding site [chemical binding]; other site 189518006615 Phosphotransferase enzyme family; Region: APH; pfam01636 189518006616 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518006617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518006618 active site 189518006619 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 189518006620 substrate binding site [chemical binding]; other site 189518006621 multimerization interface [polypeptide binding]; other site 189518006622 ATP binding site [chemical binding]; other site 189518006623 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189518006624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518006625 substrate binding site [chemical binding]; other site 189518006626 oxyanion hole (OAH) forming residues; other site 189518006627 trimer interface [polypeptide binding]; other site 189518006628 Cupin; Region: Cupin_6; pfam12852 189518006629 Uncharacterized conserved protein [Function unknown]; Region: COG3391 189518006630 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 189518006631 structural tetrad; other site 189518006632 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 189518006633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518006634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518006635 ligand binding site [chemical binding]; other site 189518006636 flexible hinge region; other site 189518006637 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 189518006638 Uncharacterized N-terminal domain of the transcription elongation factor GreA [Function unknown]; Region: COG1747 189518006639 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 189518006640 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 189518006641 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 189518006642 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 189518006643 Protein of unknown function (DUF1563); Region: DUF1563; pfam07599 189518006644 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 189518006645 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518006646 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 189518006647 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 189518006648 active site 189518006649 metal binding site [ion binding]; metal-binding site 189518006650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 189518006651 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 189518006652 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 189518006653 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 189518006654 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 189518006655 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 189518006656 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 189518006657 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14322 189518006658 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 189518006659 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 189518006660 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 189518006661 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 189518006662 motif 1; other site 189518006663 active site 189518006664 motif 2; other site 189518006665 motif 3; other site 189518006666 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 189518006667 DHHA1 domain; Region: DHHA1; pfam02272 189518006668 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 189518006669 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 189518006670 23S rRNA interface [nucleotide binding]; other site 189518006671 L3 interface [polypeptide binding]; other site 189518006672 YceI-like domain; Region: YceI; pfam04264 189518006673 thiamine monophosphate kinase; Provisional; Region: PRK05731 189518006674 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 189518006675 ATP binding site [chemical binding]; other site 189518006676 dimerization interface [polypeptide binding]; other site 189518006677 30S ribosomal protein S7; Validated; Region: PRK05302 189518006678 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 189518006679 S17 interaction site [polypeptide binding]; other site 189518006680 S8 interaction site; other site 189518006681 16S rRNA interaction site [nucleotide binding]; other site 189518006682 streptomycin interaction site [chemical binding]; other site 189518006683 23S rRNA interaction site [nucleotide binding]; other site 189518006684 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 189518006685 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 189518006686 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 189518006687 beta and beta' interface [polypeptide binding]; other site 189518006688 beta' and sigma factor interface [polypeptide binding]; other site 189518006689 Zn-binding [ion binding]; other site 189518006690 active site region [active] 189518006691 catalytic site [active] 189518006692 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 189518006693 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 189518006694 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 189518006695 DNA binding site [nucleotide binding] 189518006696 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 189518006697 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 189518006698 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 189518006699 RPB12 interaction site [polypeptide binding]; other site 189518006700 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 189518006701 RPB1 interaction site [polypeptide binding]; other site 189518006702 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 189518006703 RPB10 interaction site [polypeptide binding]; other site 189518006704 RPB11 interaction site [polypeptide binding]; other site 189518006705 RPB3 interaction site [polypeptide binding]; other site 189518006706 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 189518006707 core dimer interface [polypeptide binding]; other site 189518006708 peripheral dimer interface [polypeptide binding]; other site 189518006709 L10 interface [polypeptide binding]; other site 189518006710 L11 interface [polypeptide binding]; other site 189518006711 putative EF-Tu interaction site [polypeptide binding]; other site 189518006712 putative EF-G interaction site [polypeptide binding]; other site 189518006713 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 189518006714 23S rRNA interface [nucleotide binding]; other site 189518006715 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 189518006716 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 189518006717 mRNA/rRNA interface [nucleotide binding]; other site 189518006718 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 189518006719 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 189518006720 23S rRNA interface [nucleotide binding]; other site 189518006721 L7/L12 interface [polypeptide binding]; other site 189518006722 putative thiostrepton binding site; other site 189518006723 L25 interface [polypeptide binding]; other site 189518006724 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 189518006725 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 189518006726 putative homodimer interface [polypeptide binding]; other site 189518006727 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 189518006728 heterodimer interface [polypeptide binding]; other site 189518006729 homodimer interface [polypeptide binding]; other site 189518006730 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 189518006731 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006732 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 189518006733 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 189518006734 active site 189518006735 metal binding site [ion binding]; metal-binding site 189518006736 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 189518006737 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 189518006738 ATP binding site [chemical binding]; other site 189518006739 Mg++ binding site [ion binding]; other site 189518006740 motif III; other site 189518006741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518006742 nucleotide binding region [chemical binding]; other site 189518006743 ATP-binding site [chemical binding]; other site 189518006744 Methyltransferase domain; Region: Methyltransf_31; pfam13847 189518006745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518006746 S-adenosylmethionine binding site [chemical binding]; other site 189518006747 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 189518006748 homotrimer interaction site [polypeptide binding]; other site 189518006749 putative active site [active] 189518006750 multifunctional aminopeptidase A; Provisional; Region: PRK00913 189518006751 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 189518006752 interface (dimer of trimers) [polypeptide binding]; other site 189518006753 Substrate-binding/catalytic site; other site 189518006754 Zn-binding sites [ion binding]; other site 189518006755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 189518006756 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 189518006757 catalytic triad [active] 189518006758 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 189518006759 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 189518006760 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 189518006761 active site 189518006762 Riboflavin kinase; Region: Flavokinase; smart00904 189518006763 PAS domain S-box; Region: sensory_box; TIGR00229 189518006764 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518006765 PAS domain; Region: PAS_9; pfam13426 189518006766 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518006767 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 189518006768 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 189518006769 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 189518006770 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 189518006771 amphipathic channel; other site 189518006772 Asn-Pro-Ala signature motifs; other site 189518006773 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518006774 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518006775 polyphosphate kinase; Provisional; Region: PRK05443 189518006776 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 189518006777 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 189518006778 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 189518006779 putative domain interface [polypeptide binding]; other site 189518006780 putative active site [active] 189518006781 catalytic site [active] 189518006782 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 189518006783 putative domain interface [polypeptide binding]; other site 189518006784 putative active site [active] 189518006785 catalytic site [active] 189518006786 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 189518006787 FAD binding domain; Region: FAD_binding_4; pfam01565 189518006788 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 189518006789 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 189518006790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518006791 Coenzyme A binding pocket [chemical binding]; other site 189518006792 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 189518006793 putative active site [active] 189518006794 catalytic triad [active] 189518006795 putative dimer interface [polypeptide binding]; other site 189518006796 Transmembrane family 220, helix; Region: TMEM220; pfam15071 189518006797 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 189518006798 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 189518006799 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 189518006800 active site 189518006801 Zn binding site [ion binding]; other site 189518006802 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 189518006803 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518006804 Imelysin; Region: Peptidase_M75; cl09159 189518006805 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 189518006806 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 189518006807 Imelysin; Region: Peptidase_M75; pfam09375 189518006808 DUF35 OB-fold domain; Region: DUF35; pfam01796 189518006809 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189518006810 active site 189518006811 oxyanion hole [active] 189518006812 Transposase; Region: HTH_Tnp_1; cl17663 189518006813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189518006814 putative transposase OrfB; Reviewed; Region: PHA02517 189518006815 Integrase core domain; Region: rve; pfam00665 189518006816 Integrase core domain; Region: rve_3; pfam13683 189518006817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518006818 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 189518006819 NAD(P) binding site [chemical binding]; other site 189518006820 active site 189518006821 Predicted esterase [General function prediction only]; Region: COG0400 189518006822 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 189518006823 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 189518006824 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 189518006825 Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401 189518006826 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 189518006827 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 189518006828 PhoU domain; Region: PhoU; pfam01895 189518006829 PhoU domain; Region: PhoU; pfam01895 189518006830 MAPEG family; Region: MAPEG; pfam01124 189518006831 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 189518006832 Protein of unknown function (DUF3286); Region: DUF3286; pfam11689 189518006833 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189518006834 HAMP domain; Region: HAMP; pfam00672 189518006835 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518006836 dimer interface [polypeptide binding]; other site 189518006837 putative CheW interface [polypeptide binding]; other site 189518006838 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 189518006839 Methylamine utilization protein MauL; Region: MauL; cd04221 189518006840 putative Type 1 (T1) Cu binding site [ion binding]; other site 189518006841 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 189518006842 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 189518006843 Cytochrome c; Region: Cytochrom_C; pfam00034 189518006844 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 189518006845 putative active site [active] 189518006846 catalytic triad [active] 189518006847 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 189518006848 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 189518006849 ATP binding site [chemical binding]; other site 189518006850 active site 189518006851 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 189518006852 substrate binding site [chemical binding]; other site 189518006853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518006854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518006855 active site 189518006856 phosphorylation site [posttranslational modification] 189518006857 intermolecular recognition site; other site 189518006858 dimerization interface [polypeptide binding]; other site 189518006859 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518006860 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 189518006861 CcmB protein; Region: CcmB; cl17444 189518006862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518006863 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 189518006864 Walker A/P-loop; other site 189518006865 ATP binding site [chemical binding]; other site 189518006866 Q-loop/lid; other site 189518006867 ABC transporter signature motif; other site 189518006868 Walker B; other site 189518006869 D-loop; other site 189518006870 H-loop/switch region; other site 189518006871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518006872 binding surface 189518006873 TPR motif; other site 189518006874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518006875 binding surface 189518006876 TPR motif; other site 189518006877 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 189518006878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518006879 Walker A/P-loop; other site 189518006880 ATP binding site [chemical binding]; other site 189518006881 Q-loop/lid; other site 189518006882 ABC transporter signature motif; other site 189518006883 Walker B; other site 189518006884 D-loop; other site 189518006885 H-loop/switch region; other site 189518006886 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 189518006887 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 189518006888 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 189518006889 Mrr N-terminal domain; Region: Mrr_N; pfam14338 189518006890 Restriction endonuclease; Region: Mrr_cat; pfam04471 189518006891 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518006892 active site 189518006893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189518006894 dimerization interface [polypeptide binding]; other site 189518006895 putative DNA binding site [nucleotide binding]; other site 189518006896 putative Zn2+ binding site [ion binding]; other site 189518006897 DoxX-like family; Region: DoxX_2; pfam13564 189518006898 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189518006899 hydrophobic ligand binding site; other site 189518006900 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 189518006901 putative hydrophobic ligand binding site [chemical binding]; other site 189518006902 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 189518006903 putative hydrophobic ligand binding site [chemical binding]; other site 189518006904 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 189518006905 putative hydrophobic ligand binding site [chemical binding]; other site 189518006906 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 189518006907 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 189518006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518006909 putative substrate translocation pore; other site 189518006910 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 189518006911 putative catalytic site [active] 189518006912 metal binding site A [ion binding]; metal-binding site 189518006913 phosphate binding site [ion binding]; other site 189518006914 metal binding site C [ion binding]; metal-binding site 189518006915 metal binding site B [ion binding]; metal-binding site 189518006916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518006917 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518006918 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518006919 Membrane protein of unknown function; Region: DUF360; pfam04020 189518006920 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 189518006921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518006922 S-adenosylmethionine binding site [chemical binding]; other site 189518006923 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 189518006924 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 189518006925 Uncharacterized conserved protein [Function unknown]; Region: COG4121 189518006926 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 189518006927 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 189518006928 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 189518006929 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 189518006930 FMN binding site [chemical binding]; other site 189518006931 active site 189518006932 catalytic residues [active] 189518006933 substrate binding site [chemical binding]; other site 189518006934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 189518006935 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 189518006936 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 189518006937 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 189518006938 trimerization site [polypeptide binding]; other site 189518006939 active site 189518006940 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 189518006941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518006942 catalytic residue [active] 189518006943 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 189518006944 [2Fe-2S] cluster binding site [ion binding]; other site 189518006945 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 189518006946 FeS assembly protein SufD; Region: sufD; TIGR01981 189518006947 FeS assembly ATPase SufC; Region: sufC; TIGR01978 189518006948 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 189518006949 Walker A/P-loop; other site 189518006950 ATP binding site [chemical binding]; other site 189518006951 Q-loop/lid; other site 189518006952 ABC transporter signature motif; other site 189518006953 Walker B; other site 189518006954 D-loop; other site 189518006955 H-loop/switch region; other site 189518006956 Protein required for attachment to host cells; Region: Host_attach; pfam10116 189518006957 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 189518006958 metazoan glycerol kinase 5-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK5_metazoa; cd07793 189518006959 putative N- and C-terminal domain interface [polypeptide binding]; other site 189518006960 putative active site [active] 189518006961 putative MgATP binding site [chemical binding]; other site 189518006962 catalytic site [active] 189518006963 metal binding site [ion binding]; metal-binding site 189518006964 putative homotetramer interface [polypeptide binding]; other site 189518006965 putative homodimer interface [polypeptide binding]; other site 189518006966 putative glycerol binding site [chemical binding]; other site 189518006967 Cytochrome c; Region: Cytochrom_C; pfam00034 189518006968 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518006969 anti sigma factor interaction site; other site 189518006970 regulatory phosphorylation site [posttranslational modification]; other site 189518006971 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 189518006972 Ligand binding site; other site 189518006973 oligomer interface; other site 189518006974 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 189518006975 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 189518006976 flagellar motor protein MotB; Validated; Region: motB; PRK06667 189518006977 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 189518006978 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518006979 ligand binding site [chemical binding]; other site 189518006980 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 189518006981 Flagellar protein (FlbD); Region: FlbD; pfam06289 189518006982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518006983 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 189518006984 putative ADP-binding pocket [chemical binding]; other site 189518006985 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 189518006986 putative active site [active] 189518006987 metal binding site [ion binding]; metal-binding site 189518006988 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 189518006989 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; pfam05090 189518006990 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 189518006991 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 189518006992 Foie gras liver health family 1; Region: Foie-gras_1; pfam11817 189518006993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518006994 binding surface 189518006995 TPR motif; other site 189518006996 Predicted membrane protein [Function unknown]; Region: COG4270 189518006997 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 189518006998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518006999 Coenzyme A binding pocket [chemical binding]; other site 189518007000 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 189518007001 homotrimer interaction site [polypeptide binding]; other site 189518007002 zinc binding site [ion binding]; other site 189518007003 CDP-binding sites; other site 189518007004 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518007005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007006 TPR motif; other site 189518007007 binding surface 189518007008 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 189518007009 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 189518007010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518007011 Walker A motif; other site 189518007012 ATP binding site [chemical binding]; other site 189518007013 Walker B motif; other site 189518007014 arginine finger; other site 189518007015 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 189518007016 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 189518007017 inhibitor-cofactor binding pocket; inhibition site 189518007018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518007019 catalytic residue [active] 189518007020 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 189518007021 Ferritin-like domain; Region: Ferritin; pfam00210 189518007022 dimerization interface [polypeptide binding]; other site 189518007023 DPS ferroxidase diiron center [ion binding]; other site 189518007024 ion pore; other site 189518007025 Domain of unknown function (DUF4546); Region: DUF4546; pfam15079 189518007026 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189518007027 hydrophobic ligand binding site; other site 189518007028 arylsulfatase; Provisional; Region: PRK13759 189518007029 Sulfatase; Region: Sulfatase; pfam00884 189518007030 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 189518007031 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 189518007032 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 189518007033 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 189518007034 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 189518007035 active site 189518007036 catalytic site [active] 189518007037 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 189518007038 active site 189518007039 catalytic site [active] 189518007040 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 189518007041 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 189518007042 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518007043 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518007044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007045 TPR motif; other site 189518007046 binding surface 189518007047 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518007048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007049 binding surface 189518007050 TPR motif; other site 189518007051 Protein of unknown function (DUF1562); Region: DUF1562; pfam07601 189518007052 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 189518007053 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 189518007054 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 189518007055 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518007056 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518007057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007058 binding surface 189518007059 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518007060 TPR motif; other site 189518007061 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 189518007062 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518007063 ligand binding site [chemical binding]; other site 189518007064 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 189518007065 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 189518007066 active site 189518007067 nucleophile elbow; other site 189518007068 potential frameshift: common BLAST hit: gi|24216770|ref|NP_714251.1| transposase 189518007069 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007071 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007072 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007073 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 189518007074 ammonium transporter; Region: amt; TIGR00836 189518007075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518007076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518007077 dimer interface [polypeptide binding]; other site 189518007078 putative CheW interface [polypeptide binding]; other site 189518007079 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 189518007080 putative active site [active] 189518007081 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 189518007082 putative dimer interface [polypeptide binding]; other site 189518007083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518007084 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 189518007085 putative ADP-binding pocket [chemical binding]; other site 189518007086 DNA polymerase I; Provisional; Region: PRK05755 189518007087 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 189518007088 active site 189518007089 metal binding site 1 [ion binding]; metal-binding site 189518007090 putative 5' ssDNA interaction site; other site 189518007091 metal binding site 3; metal-binding site 189518007092 metal binding site 2 [ion binding]; metal-binding site 189518007093 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 189518007094 putative DNA binding site [nucleotide binding]; other site 189518007095 putative metal binding site [ion binding]; other site 189518007096 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 189518007097 active site 189518007098 catalytic site [active] 189518007099 substrate binding site [chemical binding]; other site 189518007100 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 189518007101 active site 189518007102 DNA binding site [nucleotide binding] 189518007103 catalytic site [active] 189518007104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518007105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518007106 active site 189518007107 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 189518007108 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 189518007109 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 189518007110 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 189518007111 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 189518007112 glutamine binding [chemical binding]; other site 189518007113 catalytic triad [active] 189518007114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189518007115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189518007116 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 189518007117 Walker A/P-loop; other site 189518007118 ATP binding site [chemical binding]; other site 189518007119 Q-loop/lid; other site 189518007120 ABC transporter signature motif; other site 189518007121 Walker B; other site 189518007122 D-loop; other site 189518007123 H-loop/switch region; other site 189518007124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007125 active site 189518007126 phosphorylation site [posttranslational modification] 189518007127 intermolecular recognition site; other site 189518007128 HEAT repeats; Region: HEAT_2; pfam13646 189518007129 HEAT-like repeat; Region: HEAT_EZ; pfam13513 189518007130 HEAT repeats; Region: HEAT_2; pfam13646 189518007131 HEAT repeats; Region: HEAT_2; pfam13646 189518007132 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 189518007133 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 189518007134 HflX GTPase family; Region: HflX; cd01878 189518007135 G1 box; other site 189518007136 GTP/Mg2+ binding site [chemical binding]; other site 189518007137 Switch I region; other site 189518007138 G2 box; other site 189518007139 G3 box; other site 189518007140 Switch II region; other site 189518007141 G4 box; other site 189518007142 G5 box; other site 189518007143 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 189518007144 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 189518007145 active site 189518007146 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 189518007147 homoserine dehydrogenase; Provisional; Region: PRK06349 189518007148 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 189518007149 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 189518007150 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 189518007151 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518007152 anti sigma factor interaction site; other site 189518007153 regulatory phosphorylation site [posttranslational modification]; other site 189518007154 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518007155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 189518007156 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 189518007157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 189518007158 substrate binding site [chemical binding]; other site 189518007159 oxyanion hole (OAH) forming residues; other site 189518007160 trimer interface [polypeptide binding]; other site 189518007161 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 189518007162 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 189518007163 dimer interface [polypeptide binding]; other site 189518007164 ssDNA binding site [nucleotide binding]; other site 189518007165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 189518007166 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 189518007167 Cu(I) binding site [ion binding]; other site 189518007168 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 189518007169 YHYH protein; Region: YHYH; pfam14240 189518007170 RNA polymerase sigma factor; Provisional; Region: PRK11924 189518007171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518007172 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 189518007173 DNA binding residues [nucleotide binding] 189518007174 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 189518007175 dimer interface [polypeptide binding]; other site 189518007176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518007177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007178 active site 189518007179 phosphorylation site [posttranslational modification] 189518007180 intermolecular recognition site; other site 189518007181 dimerization interface [polypeptide binding]; other site 189518007182 SnoaL-like domain; Region: SnoaL_2; pfam12680 189518007183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518007184 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518007185 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 189518007186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518007187 dimer interface [polypeptide binding]; other site 189518007188 phosphorylation site [posttranslational modification] 189518007189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518007190 ATP binding site [chemical binding]; other site 189518007191 Mg2+ binding site [ion binding]; other site 189518007192 G-X-G motif; other site 189518007193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518007194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007195 active site 189518007196 phosphorylation site [posttranslational modification] 189518007197 intermolecular recognition site; other site 189518007198 dimerization interface [polypeptide binding]; other site 189518007199 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 189518007200 putative heme binding pocket [chemical binding]; other site 189518007201 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518007202 anti sigma factor interaction site; other site 189518007203 regulatory phosphorylation site [posttranslational modification]; other site 189518007204 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 189518007205 active site 189518007206 dimerization interface [polypeptide binding]; other site 189518007207 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 189518007208 Fe-S cluster binding site [ion binding]; other site 189518007209 active site 189518007210 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 189518007211 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518007212 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518007213 methionine sulfoxide reductase A; Provisional; Region: PRK14054 189518007214 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 189518007215 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 189518007216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518007217 FAD binding site [chemical binding]; other site 189518007218 substrate binding site [chemical binding]; other site 189518007219 catalytic residues [active] 189518007220 SLEI; Region: SLEI_Leptospira; pfam07620 189518007221 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 189518007222 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 189518007223 trimer interface [polypeptide binding]; other site 189518007224 active site 189518007225 substrate binding site [chemical binding]; other site 189518007226 CoA binding site [chemical binding]; other site 189518007227 Pathogenicity locus; Region: Cdd1; pfam11731 189518007228 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 189518007229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518007230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518007231 Walker A/P-loop; other site 189518007232 ATP binding site [chemical binding]; other site 189518007233 Q-loop/lid; other site 189518007234 ABC transporter signature motif; other site 189518007235 Walker B; other site 189518007236 ABC transporter; Region: ABC_tran_2; pfam12848 189518007237 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 189518007238 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 189518007239 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 189518007240 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518007241 ligand binding site [chemical binding]; other site 189518007242 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 189518007243 Protein of unknown function; Region: DUF3658; pfam12395 189518007244 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 189518007245 Protein of unknown function; Region: DUF3658; pfam12395 189518007246 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 189518007247 Transglycosylase; Region: Transgly; pfam00912 189518007248 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 189518007249 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 189518007250 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 189518007251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 189518007252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 189518007253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518007254 Walker A/P-loop; other site 189518007255 ATP binding site [chemical binding]; other site 189518007256 Q-loop/lid; other site 189518007257 ABC transporter signature motif; other site 189518007258 Walker B; other site 189518007259 D-loop; other site 189518007260 H-loop/switch region; other site 189518007261 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 189518007262 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 189518007263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 189518007264 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 189518007265 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 189518007266 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 189518007267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 189518007268 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 189518007269 Low molecular weight phosphatase family; Region: LMWPc; cl00105 189518007270 active site 189518007271 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 189518007272 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 189518007273 HrcA protein C terminal domain; Region: HrcA; pfam01628 189518007274 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 189518007275 dimer interface [polypeptide binding]; other site 189518007276 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 189518007277 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 189518007278 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 189518007279 nucleotide binding site [chemical binding]; other site 189518007280 NEF interaction site [polypeptide binding]; other site 189518007281 SBD interface [polypeptide binding]; other site 189518007282 chaperone protein DnaJ; Provisional; Region: PRK14286 189518007283 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 189518007284 HSP70 interaction site [polypeptide binding]; other site 189518007285 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 189518007286 substrate binding site [polypeptide binding]; other site 189518007287 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 189518007288 Zn binding sites [ion binding]; other site 189518007289 dimer interface [polypeptide binding]; other site 189518007290 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 189518007291 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 189518007292 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 189518007293 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 189518007294 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 189518007295 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 189518007296 FtsX-like permease family; Region: FtsX; pfam02687 189518007297 FtsX-like permease family; Region: FtsX; pfam02687 189518007298 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 189518007299 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 189518007300 Walker A/P-loop; other site 189518007301 ATP binding site [chemical binding]; other site 189518007302 Q-loop/lid; other site 189518007303 ABC transporter signature motif; other site 189518007304 Walker B; other site 189518007305 D-loop; other site 189518007306 H-loop/switch region; other site 189518007307 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 189518007308 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 189518007309 active site 189518007310 HIGH motif; other site 189518007311 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 189518007312 KMSKS motif; other site 189518007313 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 189518007314 tRNA binding surface [nucleotide binding]; other site 189518007315 Integrase core domain; Region: rve; pfam00665 189518007316 Integrase core domain; Region: rve_3; pfam13683 189518007317 Geminivirus BL1 movement protein; Region: Gemini_BL1; pfam00845 189518007318 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 189518007319 thioester formation/cholesterol transfer; other site 189518007320 protein-splicing catalytic site; other site 189518007321 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 189518007322 Staphylococcal nuclease homologue; Region: SNase; cl00140 189518007323 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160 189518007324 Pretoxin HINT domain; Region: PT-HINT; pfam07591 189518007325 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 189518007326 thioester formation/cholesterol transfer; other site 189518007327 protein-splicing catalytic site; other site 189518007328 Putative Ig domain; Region: He_PIG; pfam05345 189518007329 Putative Ig domain; Region: He_PIG; pfam05345 189518007330 Cadherin repeat-like domain; Region: CA_like; cl15786 189518007331 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518007332 Fn3 associated; Region: Fn3_assoc; pfam13287 189518007333 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007334 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518007335 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 189518007336 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007337 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518007338 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518007339 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 189518007340 Outer membrane efflux protein; Region: OEP; pfam02321 189518007341 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 189518007342 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007343 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007344 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007345 Tetratricopeptide repeat; Region: TPR_19; pfam14559 189518007346 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 189518007347 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 189518007348 HlyD family secretion protein; Region: HlyD_3; pfam13437 189518007349 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518007350 MMPL family; Region: MMPL; cl14618 189518007351 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518007352 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518007353 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 189518007354 MORN repeat; Region: MORN; cl14787 189518007355 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 189518007356 threonine synthase; Validated; Region: PRK06260 189518007357 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 189518007358 homodimer interface [polypeptide binding]; other site 189518007359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518007360 catalytic residue [active] 189518007361 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 189518007362 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 189518007363 Short C-terminal domain; Region: SHOCT; pfam09851 189518007364 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 189518007365 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 189518007366 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 189518007367 Catalytic site [active] 189518007368 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 189518007369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 189518007370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 189518007371 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 189518007372 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 189518007373 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 189518007374 active site 189518007375 HIGH motif; other site 189518007376 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 189518007377 KMSKS motif; other site 189518007378 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 189518007379 tRNA binding surface [nucleotide binding]; other site 189518007380 anticodon binding site; other site 189518007381 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 189518007382 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13789 189518007383 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 189518007384 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 189518007385 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 189518007386 peptide chain release factor 2; Validated; Region: prfB; PRK00578 189518007387 PCRF domain; Region: PCRF; pfam03462 189518007388 RF-1 domain; Region: RF-1; pfam00472 189518007389 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189518007390 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 189518007391 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518007392 Transposase; Region: HTH_Tnp_1; pfam01527 189518007393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189518007394 putative transposase OrfB; Reviewed; Region: PHA02517 189518007395 Integrase core domain; Region: rve; pfam00665 189518007396 Integrase core domain; Region: rve_3; pfam13683 189518007397 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 189518007398 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007399 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007400 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007401 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 189518007402 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007403 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007404 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 189518007405 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007406 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007407 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007408 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007409 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007410 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 189518007411 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 189518007412 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 189518007413 active site 189518007414 purine riboside binding site [chemical binding]; other site 189518007415 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518007416 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 189518007417 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 189518007418 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 189518007419 Ligand binding site; other site 189518007420 Putative Catalytic site; other site 189518007421 DXD motif; other site 189518007422 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 189518007423 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 189518007424 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803 189518007425 active site 189518007426 substrate binding site [chemical binding]; other site 189518007427 metal binding site [ion binding]; metal-binding site 189518007428 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 189518007429 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 189518007430 glutaminase active site [active] 189518007431 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 189518007432 dimer interface [polypeptide binding]; other site 189518007433 active site 189518007434 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 189518007435 dimer interface [polypeptide binding]; other site 189518007436 active site 189518007437 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 189518007438 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 189518007439 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 189518007440 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 189518007441 Protein of unknown function (DUF1567); Region: DUF1567; pfam07604 189518007442 Protein of unknown function (DUF1567); Region: DUF1567; pfam07604 189518007443 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 189518007444 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 189518007445 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 189518007446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518007447 S-adenosylmethionine binding site [chemical binding]; other site 189518007448 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 189518007449 EVE domain; Region: EVE; cl00728 189518007450 FtsH Extracellular; Region: FtsH_ext; pfam06480 189518007451 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 189518007452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518007453 Walker A motif; other site 189518007454 ATP binding site [chemical binding]; other site 189518007455 Walker B motif; other site 189518007456 arginine finger; other site 189518007457 Peptidase family M41; Region: Peptidase_M41; pfam01434 189518007458 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 189518007459 putative active site [active] 189518007460 catalytic residue [active] 189518007461 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 189518007462 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 189518007463 5S rRNA interface [nucleotide binding]; other site 189518007464 CTC domain interface [polypeptide binding]; other site 189518007465 L16 interface [polypeptide binding]; other site 189518007466 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 189518007467 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 189518007468 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 189518007469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189518007470 active site 189518007471 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 189518007472 Substrate binding site; other site 189518007473 Mg++ binding site; other site 189518007474 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14613 189518007475 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 189518007476 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 189518007477 Predicted transcriptional regulator [Transcription]; Region: COG2378 189518007478 WYL domain; Region: WYL; pfam13280 189518007479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007480 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007481 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007482 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 189518007483 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 189518007484 Beta-propeller repeat; Region: SBBP; pfam06739 189518007485 Beta-propeller repeat; Region: SBBP; pfam06739 189518007486 Beta-propeller repeat; Region: SBBP; pfam06739 189518007487 Beta-propeller repeat; Region: SBBP; pfam06739 189518007488 Beta-propeller repeat; Region: SBBP; pfam06739 189518007489 PQQ-like domain; Region: PQQ_2; pfam13360 189518007490 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 189518007491 substrate binding site [chemical binding]; other site 189518007492 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 189518007493 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518007494 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518007495 cyclase homology domain; Region: CHD; cd07302 189518007496 nucleotidyl binding site; other site 189518007497 metal binding site [ion binding]; metal-binding site 189518007498 dimer interface [polypeptide binding]; other site 189518007499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518007500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518007501 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518007502 MMPL family; Region: MMPL; cl14618 189518007503 MMPL family; Region: MMPL; cl14618 189518007504 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518007505 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 189518007506 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518007507 Predicted membrane protein [Function unknown]; Region: COG2259 189518007508 Pirin-related protein [General function prediction only]; Region: COG1741 189518007509 Pirin; Region: Pirin; pfam02678 189518007510 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 189518007511 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 189518007512 hydrophobic ligand binding site; other site 189518007513 Sporulation related domain; Region: SPOR; pfam05036 189518007514 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 189518007515 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 189518007516 ATP-binding [chemical binding]; other site 189518007517 CoA-binding site [chemical binding]; other site 189518007518 PAS domain; Region: PAS_9; pfam13426 189518007519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518007520 putative active site [active] 189518007521 heme pocket [chemical binding]; other site 189518007522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518007523 Histidine kinase; Region: HisKA_3; pfam07730 189518007524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518007525 ATP binding site [chemical binding]; other site 189518007526 Mg2+ binding site [ion binding]; other site 189518007527 G-X-G motif; other site 189518007528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518007529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007530 active site 189518007531 phosphorylation site [posttranslational modification] 189518007532 intermolecular recognition site; other site 189518007533 dimerization interface [polypeptide binding]; other site 189518007534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189518007535 DNA binding residues [nucleotide binding] 189518007536 dimerization interface [polypeptide binding]; other site 189518007537 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518007538 MMPL family; Region: MMPL; cl14618 189518007539 MMPL family; Region: MMPL; cl14618 189518007540 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 189518007541 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 189518007542 tandem repeat interface [polypeptide binding]; other site 189518007543 oligomer interface [polypeptide binding]; other site 189518007544 active site residues [active] 189518007545 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 189518007546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007547 binding surface 189518007548 TPR motif; other site 189518007549 TPR repeat; Region: TPR_11; pfam13414 189518007550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007551 binding surface 189518007552 TPR motif; other site 189518007553 TPR repeat; Region: TPR_11; pfam13414 189518007554 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 189518007555 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 189518007556 putative NAD(P) binding site [chemical binding]; other site 189518007557 putative active site [active] 189518007558 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007559 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007560 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007561 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007562 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007563 Bacterial Ig-like domain; Region: Big_5; pfam13205 189518007564 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 189518007565 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 189518007566 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 189518007567 FG-GAP repeat; Region: FG-GAP; pfam01839 189518007568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007569 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007570 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007571 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 189518007572 ligand binding site [chemical binding]; other site 189518007573 active site 189518007574 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518007575 anti sigma factor interaction site; other site 189518007576 regulatory phosphorylation site [posttranslational modification]; other site 189518007577 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 189518007578 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 189518007579 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 189518007580 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 189518007581 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 189518007582 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 189518007583 active site 189518007584 dimer interface [polypeptide binding]; other site 189518007585 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 189518007586 dimer interface [polypeptide binding]; other site 189518007587 active site 189518007588 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 189518007589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518007590 active site 189518007591 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 189518007592 Phosphotransferase enzyme family; Region: APH; pfam01636 189518007593 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 189518007594 substrate binding site [chemical binding]; other site 189518007595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007596 active site 189518007597 phosphorylation site [posttranslational modification] 189518007598 intermolecular recognition site; other site 189518007599 dimerization interface [polypeptide binding]; other site 189518007600 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 189518007601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518007602 putative active site [active] 189518007603 heme pocket [chemical binding]; other site 189518007604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518007605 dimer interface [polypeptide binding]; other site 189518007606 phosphorylation site [posttranslational modification] 189518007607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518007608 ATP binding site [chemical binding]; other site 189518007609 Mg2+ binding site [ion binding]; other site 189518007610 G-X-G motif; other site 189518007611 PAS domain; Region: PAS_9; pfam13426 189518007612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518007613 putative active site [active] 189518007614 heme pocket [chemical binding]; other site 189518007615 PAS domain; Region: PAS_9; pfam13426 189518007616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518007617 putative active site [active] 189518007618 heme pocket [chemical binding]; other site 189518007619 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 189518007620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518007621 dimer interface [polypeptide binding]; other site 189518007622 phosphorylation site [posttranslational modification] 189518007623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518007624 ATP binding site [chemical binding]; other site 189518007625 Mg2+ binding site [ion binding]; other site 189518007626 G-X-G motif; other site 189518007627 Predicted membrane protein (DUF2070); Region: DUF2070; cl19221 189518007628 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518007629 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518007630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007631 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007632 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007633 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007635 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007636 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 189518007637 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 189518007638 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 189518007639 inhibitor-cofactor binding pocket; inhibition site 189518007640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518007641 catalytic residue [active] 189518007642 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 189518007643 metal binding site [ion binding]; metal-binding site 189518007644 nucleotidyl binding site; other site 189518007645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518007646 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 189518007647 Uncharacterized conserved protein [Function unknown]; Region: COG3937 189518007648 HEAT repeats; Region: HEAT_2; pfam13646 189518007649 HEAT repeats; Region: HEAT_2; pfam13646 189518007650 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 189518007651 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518007652 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 189518007653 tellurium resistance terB-like protein; Region: terB_like; cl11965 189518007654 metal binding site [ion binding]; metal-binding site 189518007655 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 189518007656 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 189518007657 active site 189518007658 HIGH motif; other site 189518007659 KMSKS motif; other site 189518007660 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 189518007661 tRNA binding surface [nucleotide binding]; other site 189518007662 anticodon binding site; other site 189518007663 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 189518007664 dimer interface [polypeptide binding]; other site 189518007665 putative tRNA-binding site [nucleotide binding]; other site 189518007666 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 189518007667 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 189518007668 metal binding triad; other site 189518007669 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 189518007670 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 189518007671 HD domain; Region: HD; pfam01966 189518007672 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 189518007673 YceI-like domain; Region: YceI; smart00867 189518007674 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189518007675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518007676 NAD(P) binding site [chemical binding]; other site 189518007677 active site 189518007678 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 189518007679 Outer membrane efflux protein; Region: OEP; pfam02321 189518007680 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 189518007681 Outer membrane efflux protein; Region: OEP; pfam02321 189518007682 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518007683 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518007684 active site 189518007685 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189518007686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518007687 metal binding site [ion binding]; metal-binding site 189518007688 active site 189518007689 I-site; other site 189518007690 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 189518007691 FAD binding domain; Region: FAD_binding_4; pfam01565 189518007692 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 189518007693 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 189518007694 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 189518007695 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 189518007696 Domain of unknown function DUF21; Region: DUF21; pfam01595 189518007697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 189518007698 Transporter associated domain; Region: CorC_HlyC; smart01091 189518007699 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 189518007700 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 189518007701 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 189518007702 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 189518007703 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 189518007704 active site 189518007705 metal binding site [ion binding]; metal-binding site 189518007706 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 189518007707 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 189518007708 generic binding surface II; other site 189518007709 ssDNA binding site; other site 189518007710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518007711 ATP binding site [chemical binding]; other site 189518007712 putative Mg++ binding site [ion binding]; other site 189518007713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518007714 nucleotide binding region [chemical binding]; other site 189518007715 ATP-binding site [chemical binding]; other site 189518007716 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 189518007717 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 189518007718 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 189518007719 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 189518007720 NAD binding site [chemical binding]; other site 189518007721 homodimer interface [polypeptide binding]; other site 189518007722 active site 189518007723 substrate binding site [chemical binding]; other site 189518007724 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 189518007725 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 189518007726 active site 189518007727 Hpt domain; Region: Hpt; pfam01627 189518007728 putative binding surface; other site 189518007729 active site 189518007730 Fic family protein [Function unknown]; Region: COG3177 189518007731 Fic/DOC family; Region: Fic; pfam02661 189518007732 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007735 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007739 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 189518007740 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 189518007741 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 189518007742 active site 189518007743 oligomerization interface [polypeptide binding]; other site 189518007744 metal binding site [ion binding]; metal-binding site 189518007745 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 189518007746 catalytic center binding site [active] 189518007747 ATP binding site [chemical binding]; other site 189518007748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518007749 Walker A motif; other site 189518007750 ATP binding site [chemical binding]; other site 189518007751 Walker B motif; other site 189518007752 arginine finger; other site 189518007753 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 189518007754 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 189518007755 NADP-binding site; other site 189518007756 homotetramer interface [polypeptide binding]; other site 189518007757 substrate binding site [chemical binding]; other site 189518007758 homodimer interface [polypeptide binding]; other site 189518007759 active site 189518007760 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 189518007761 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 189518007762 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518007763 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 189518007764 active site 189518007765 Cation transport protein; Region: TrkH; cl17365 189518007766 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 189518007767 Cation transport protein; Region: TrkH; cl17365 189518007768 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 189518007769 TrkA-N domain; Region: TrkA_N; pfam02254 189518007770 TrkA-C domain; Region: TrkA_C; pfam02080 189518007771 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 189518007772 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 189518007773 active site 189518007774 catalytic tetrad [active] 189518007775 Acylphosphatase; Region: Acylphosphatase; pfam00708 189518007776 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 189518007777 apolar tunnel; other site 189518007778 heme binding site [chemical binding]; other site 189518007779 dimerization interface [polypeptide binding]; other site 189518007780 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 189518007781 putative active site [active] 189518007782 Ap4A binding site [chemical binding]; other site 189518007783 nudix motif; other site 189518007784 putative metal binding site [ion binding]; other site 189518007785 SET domain; Region: SET; pfam00856 189518007786 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 189518007787 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 189518007788 active site 189518007789 catalytic site [active] 189518007790 metal binding site [ion binding]; metal-binding site 189518007791 dimer interface [polypeptide binding]; other site 189518007792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007793 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007794 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007795 MltA specific insert domain; Region: MltA; smart00925 189518007796 3D domain; Region: 3D; pfam06725 189518007797 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 189518007798 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518007799 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518007800 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 189518007801 potassium/proton antiporter; Reviewed; Region: PRK05326 189518007802 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 189518007803 TrkA-C domain; Region: TrkA_C; pfam02080 189518007804 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 189518007805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 189518007806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 189518007807 Coenzyme A binding pocket [chemical binding]; other site 189518007808 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 189518007809 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 189518007810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518007811 FeS/SAM binding site; other site 189518007812 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 189518007813 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518007814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518007815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518007816 dimer interface [polypeptide binding]; other site 189518007817 phosphorylation site [posttranslational modification] 189518007818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518007819 ATP binding site [chemical binding]; other site 189518007820 Mg2+ binding site [ion binding]; other site 189518007821 G-X-G motif; other site 189518007822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518007823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007824 active site 189518007825 phosphorylation site [posttranslational modification] 189518007826 intermolecular recognition site; other site 189518007827 dimerization interface [polypeptide binding]; other site 189518007828 GTPase RsgA; Reviewed; Region: PRK01889 189518007829 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 189518007830 RNA binding site [nucleotide binding]; other site 189518007831 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 189518007832 GTPase/Zn-binding domain interface [polypeptide binding]; other site 189518007833 GTP/Mg2+ binding site [chemical binding]; other site 189518007834 G4 box; other site 189518007835 G5 box; other site 189518007836 G1 box; other site 189518007837 Switch I region; other site 189518007838 G2 box; other site 189518007839 G3 box; other site 189518007840 Switch II region; other site 189518007841 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 189518007842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189518007843 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518007844 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189518007845 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 189518007846 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 189518007847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518007848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518007849 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189518007850 Methyltransferase domain; Region: Methyltransf_12; pfam08242 189518007851 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 189518007852 putative catalytic site [active] 189518007853 metal binding site A [ion binding]; metal-binding site 189518007854 phosphate binding site [ion binding]; other site 189518007855 metal binding site C [ion binding]; metal-binding site 189518007856 metal binding site B [ion binding]; metal-binding site 189518007857 DoxX-like family; Region: DoxX_2; pfam13564 189518007858 cyclase homology domain; Region: CHD; cd07302 189518007859 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518007860 nucleotidyl binding site; other site 189518007861 metal binding site [ion binding]; metal-binding site 189518007862 dimer interface [polypeptide binding]; other site 189518007863 cyclase homology domain; Region: CHD; cd07302 189518007864 dimer interface [polypeptide binding]; other site 189518007865 nucleotidyl binding site; other site 189518007866 metal binding site [ion binding]; metal-binding site 189518007867 AAA ATPase domain; Region: AAA_16; pfam13191 189518007868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518007869 binding surface 189518007870 TPR motif; other site 189518007871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 189518007872 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 189518007873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518007874 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189518007875 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 189518007876 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 189518007877 CoenzymeA binding site [chemical binding]; other site 189518007878 subunit interaction site [polypeptide binding]; other site 189518007879 PHB binding site; other site 189518007880 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 189518007881 Transglycosylase; Region: Transgly; pfam00912 189518007882 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 189518007883 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 189518007884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518007885 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 189518007886 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 189518007887 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 189518007888 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 189518007889 trimer interface [polypeptide binding]; other site 189518007890 putative metal binding site [ion binding]; other site 189518007891 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 189518007892 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 189518007893 putative tRNA-binding site [nucleotide binding]; other site 189518007894 B3/4 domain; Region: B3_4; pfam03483 189518007895 tRNA synthetase B5 domain; Region: B5; smart00874 189518007896 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 189518007897 dimer interface [polypeptide binding]; other site 189518007898 motif 1; other site 189518007899 motif 3; other site 189518007900 motif 2; other site 189518007901 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 189518007902 ATP-dependent helicase HepA; Validated; Region: PRK04914 189518007903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 189518007904 ATP binding site [chemical binding]; other site 189518007905 putative Mg++ binding site [ion binding]; other site 189518007906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518007907 nucleotide binding region [chemical binding]; other site 189518007908 ATP-binding site [chemical binding]; other site 189518007909 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 189518007910 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 189518007911 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 189518007912 putative acyl-acceptor binding pocket; other site 189518007913 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 189518007914 dimer interface [polypeptide binding]; other site 189518007915 substrate binding site [chemical binding]; other site 189518007916 metal binding sites [ion binding]; metal-binding site 189518007917 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 189518007918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518007919 putative substrate translocation pore; other site 189518007920 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 189518007921 Alginate export; Region: Alginate_exp; pfam13372 189518007922 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 189518007923 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 189518007924 ATP binding site [chemical binding]; other site 189518007925 Mg++ binding site [ion binding]; other site 189518007926 motif III; other site 189518007927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 189518007928 nucleotide binding region [chemical binding]; other site 189518007929 ATP-binding site [chemical binding]; other site 189518007930 Uncharacterized conserved protein [Function unknown]; Region: COG1262 189518007931 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 189518007932 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 189518007933 short chain dehydrogenase; Provisional; Region: PRK06181 189518007934 NADP binding site [chemical binding]; other site 189518007935 homodimer interface [polypeptide binding]; other site 189518007936 substrate binding site [chemical binding]; other site 189518007937 active site 189518007938 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 189518007939 Membrane transport protein; Region: Mem_trans; cl09117 189518007940 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518007941 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 189518007942 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518007943 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518007944 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518007945 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518007946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518007947 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 189518007948 outer membrane protein, LA_2444/LA_4059 family; Region: OMP_LA_2444; TIGR04327 189518007949 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 189518007950 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 189518007951 homodimer interface [polypeptide binding]; other site 189518007952 metal binding site [ion binding]; metal-binding site 189518007953 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 189518007954 homodimer interface [polypeptide binding]; other site 189518007955 active site 189518007956 putative chemical substrate binding site [chemical binding]; other site 189518007957 metal binding site [ion binding]; metal-binding site 189518007958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007959 active site 189518007960 phosphorylation site [posttranslational modification] 189518007961 intermolecular recognition site; other site 189518007962 dimerization interface [polypeptide binding]; other site 189518007963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518007964 active site 189518007965 phosphorylation site [posttranslational modification] 189518007966 intermolecular recognition site; other site 189518007967 dimerization interface [polypeptide binding]; other site 189518007968 isocitrate dehydrogenase; Validated; Region: PRK08299 189518007969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518007970 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518007971 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518007972 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518007973 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518007974 Immunity protein 14; Region: Imm14; pfam15428 189518007975 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 189518007976 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 189518007977 putative active site [active] 189518007978 catalytic triad [active] 189518007979 putative dimer interface [polypeptide binding]; other site 189518007980 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 189518007981 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 189518007982 hinge; other site 189518007983 active site 189518007984 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 189518007985 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 189518007986 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 189518007987 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 189518007988 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 189518007989 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 189518007990 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 189518007991 NADP binding site [chemical binding]; other site 189518007992 dimer interface [polypeptide binding]; other site 189518007993 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 189518007994 dimer interface [polypeptide binding]; other site 189518007995 [2Fe-2S] cluster binding site [ion binding]; other site 189518007996 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 189518007997 Vacuolar protein 14 C-terminal Fig4p binding; Region: Vac14_Fig4_bd; pfam11916 189518007998 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 189518007999 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 189518008000 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 189518008001 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 189518008002 active site 189518008003 tetramer interface [polypeptide binding]; other site 189518008004 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189518008005 active site 189518008006 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 189518008007 catalytic site [active] 189518008008 putative active site [active] 189518008009 putative substrate binding site [chemical binding]; other site 189518008010 HRDC domain; Region: HRDC; pfam00570 189518008011 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 189518008012 putative active site [active] 189518008013 putative CoA binding site [chemical binding]; other site 189518008014 nudix motif; other site 189518008015 metal binding site [ion binding]; metal-binding site 189518008016 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 189518008017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518008018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518008019 DNA binding residues [nucleotide binding] 189518008020 sodium/calcium exchanger 1; Region: caca; TIGR00845 189518008021 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518008022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518008023 active site 189518008024 phosphorylation site [posttranslational modification] 189518008025 intermolecular recognition site; other site 189518008026 dimerization interface [polypeptide binding]; other site 189518008027 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189518008028 DNA binding site [nucleotide binding] 189518008029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518008030 dimerization interface [polypeptide binding]; other site 189518008031 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 189518008032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518008033 dimer interface [polypeptide binding]; other site 189518008034 phosphorylation site [posttranslational modification] 189518008035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008036 ATP binding site [chemical binding]; other site 189518008037 Mg2+ binding site [ion binding]; other site 189518008038 G-X-G motif; other site 189518008039 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 189518008040 heterotetramer interface [polypeptide binding]; other site 189518008041 active site pocket [active] 189518008042 cleavage site 189518008043 Plasma-membrane choline transporter; Region: Choline_transpo; pfam04515 189518008044 GAF domain; Region: GAF_3; pfam13492 189518008045 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 189518008046 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518008047 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 189518008048 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189518008049 active site 189518008050 DUF35 OB-fold domain; Region: DUF35; pfam01796 189518008051 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 189518008052 dimer interaction site [polypeptide binding]; other site 189518008053 substrate-binding tunnel; other site 189518008054 active site 189518008055 catalytic site [active] 189518008056 substrate binding site [chemical binding]; other site 189518008057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 189518008058 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 189518008059 active site 189518008060 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 189518008061 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 189518008062 nucleotide binding pocket [chemical binding]; other site 189518008063 K-X-D-G motif; other site 189518008064 catalytic site [active] 189518008065 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 189518008066 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 189518008067 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 189518008068 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 189518008069 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 189518008070 Dimer interface [polypeptide binding]; other site 189518008071 BRCT sequence motif; other site 189518008072 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518008073 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518008074 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189518008075 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518008076 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 189518008077 DNA binding residues [nucleotide binding] 189518008078 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 189518008079 dimer interface [polypeptide binding]; other site 189518008080 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 189518008081 putative active site [active] 189518008082 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 189518008083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 189518008084 Histidine kinase; Region: HisKA_2; pfam07568 189518008085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008086 ATP binding site [chemical binding]; other site 189518008087 Mg2+ binding site [ion binding]; other site 189518008088 G-X-G motif; other site 189518008089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189518008090 Histidine kinase; Region: HisKA_2; pfam07568 189518008091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008092 ATP binding site [chemical binding]; other site 189518008093 Mg2+ binding site [ion binding]; other site 189518008094 G-X-G motif; other site 189518008095 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 189518008096 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 189518008097 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518008098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 189518008099 DNA binding residues [nucleotide binding] 189518008100 dimerization interface [polypeptide binding]; other site 189518008101 Peptidase family M48; Region: Peptidase_M48; cl12018 189518008102 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 189518008103 putative ADP-ribose binding site [chemical binding]; other site 189518008104 putative active site [active] 189518008105 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518008106 Predicted flavoprotein [General function prediction only]; Region: COG0431 189518008107 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 189518008108 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 189518008109 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 189518008110 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 189518008111 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 189518008112 active site 189518008113 WG containing repeat; Region: WG_beta_rep; pfam14903 189518008114 WG containing repeat; Region: WG_beta_rep; pfam14903 189518008115 WG containing repeat; Region: WG_beta_rep; pfam14903 189518008116 WG containing repeat; Region: WG_beta_rep; pfam14903 189518008117 WG containing repeat; Region: WG_beta_rep; pfam14903 189518008118 WG containing repeat; Region: WG_beta_rep; pfam14903 189518008119 MORN repeat; Region: MORN; cl14787 189518008120 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518008121 active site 189518008122 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 189518008123 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 189518008124 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 189518008125 dimer interface [polypeptide binding]; other site 189518008126 motif 1; other site 189518008127 active site 189518008128 motif 2; other site 189518008129 motif 3; other site 189518008130 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 189518008131 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 189518008132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 189518008133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 189518008134 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 189518008135 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 189518008136 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 189518008137 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 189518008138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 189518008139 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 189518008140 Walker A/P-loop; other site 189518008141 ATP binding site [chemical binding]; other site 189518008142 Q-loop/lid; other site 189518008143 ABC transporter signature motif; other site 189518008144 Walker B; other site 189518008145 D-loop; other site 189518008146 H-loop/switch region; other site 189518008147 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 189518008148 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 189518008149 nudix motif; other site 189518008150 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 189518008151 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 189518008152 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 189518008153 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 189518008154 active site 189518008155 Zn binding site [ion binding]; other site 189518008156 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 189518008157 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 189518008158 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 189518008159 active site 189518008160 Zn binding site [ion binding]; other site 189518008161 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 189518008162 ANP binding site [chemical binding]; other site 189518008163 Substrate Binding Site II [chemical binding]; other site 189518008164 Substrate Binding Site I [chemical binding]; other site 189518008165 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 189518008166 active site 189518008167 (T/H)XGH motif; other site 189518008168 Nucleoside diphosphate kinase; Region: NDK; pfam00334 189518008169 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 189518008170 active site 189518008171 multimer interface [polypeptide binding]; other site 189518008172 isocitrate dehydrogenase; Validated; Region: PRK09222 189518008173 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 189518008174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 189518008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518008176 active site 189518008177 phosphorylation site [posttranslational modification] 189518008178 intermolecular recognition site; other site 189518008179 dimerization interface [polypeptide binding]; other site 189518008180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518008181 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518008182 putative active site [active] 189518008183 heme pocket [chemical binding]; other site 189518008184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518008185 putative active site [active] 189518008186 heme pocket [chemical binding]; other site 189518008187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518008188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008189 ATP binding site [chemical binding]; other site 189518008190 Mg2+ binding site [ion binding]; other site 189518008191 G-X-G motif; other site 189518008192 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 189518008193 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 189518008194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189518008195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518008196 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 189518008197 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 189518008198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518008199 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 189518008200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518008201 homodimer interface [polypeptide binding]; other site 189518008202 catalytic residue [active] 189518008203 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 189518008204 active site 189518008205 Zn binding site [ion binding]; other site 189518008206 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 189518008207 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 189518008208 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 189518008209 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518008210 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 189518008211 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189518008212 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 189518008213 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 189518008214 active site 189518008215 HIGH motif; other site 189518008216 KMSKS motif; other site 189518008217 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 189518008218 CAP-like domain; other site 189518008219 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 189518008220 active site 189518008221 primary dimer interface [polypeptide binding]; other site 189518008222 TopoisomeraseII; Region: TOP2c; smart00433 189518008223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008224 ATP binding site [chemical binding]; other site 189518008225 Mg2+ binding site [ion binding]; other site 189518008226 G-X-G motif; other site 189518008227 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 189518008228 ATP binding site [chemical binding]; other site 189518008229 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 189518008230 active site 189518008231 putative metal-binding site [ion binding]; other site 189518008232 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 189518008233 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 189518008234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189518008235 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 189518008236 putative dimer interface [polypeptide binding]; other site 189518008237 active site pocket [active] 189518008238 putative cataytic base [active] 189518008239 cobalamin synthase; Reviewed; Region: cobS; PRK00235 189518008240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189518008241 catalytic core [active] 189518008242 von Willebrand factor type A domain; Region: VWA_2; pfam13519 189518008243 metal ion-dependent adhesion site (MIDAS); other site 189518008244 conserved hypothetical protein; Region: TIGR02231 189518008245 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 189518008246 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 189518008247 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 189518008248 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 189518008249 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 189518008250 Cl- selectivity filter; other site 189518008251 Cl- binding residues [ion binding]; other site 189518008252 pore gating glutamate residue; other site 189518008253 dimer interface [polypeptide binding]; other site 189518008254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 189518008255 CAAX protease self-immunity; Region: Abi; pfam02517 189518008256 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518008257 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 189518008258 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518008259 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 189518008260 Strictosidine synthase; Region: Str_synth; cl19733 189518008261 sulfite reductase subunit beta; Provisional; Region: PRK13504 189518008262 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189518008263 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 189518008264 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 189518008265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 189518008266 precorrin-2 dehydrogenase; Validated; Region: PRK06719 189518008267 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 189518008268 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 189518008269 active site 189518008270 SAM binding site [chemical binding]; other site 189518008271 homodimer interface [polypeptide binding]; other site 189518008272 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 189518008273 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 189518008274 CysD dimerization site [polypeptide binding]; other site 189518008275 G1 box; other site 189518008276 putative GEF interaction site [polypeptide binding]; other site 189518008277 GTP/Mg2+ binding site [chemical binding]; other site 189518008278 Switch I region; other site 189518008279 G2 box; other site 189518008280 G3 box; other site 189518008281 Switch II region; other site 189518008282 G4 box; other site 189518008283 G5 box; other site 189518008284 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 189518008285 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 189518008286 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 189518008287 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 189518008288 Active Sites [active] 189518008289 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 189518008290 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 189518008291 Active Sites [active] 189518008292 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 189518008293 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 189518008294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189518008295 dimer interface [polypeptide binding]; other site 189518008296 conserved gate region; other site 189518008297 putative PBP binding loops; other site 189518008298 ABC-ATPase subunit interface; other site 189518008299 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 189518008300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 189518008301 dimer interface [polypeptide binding]; other site 189518008302 conserved gate region; other site 189518008303 putative PBP binding loops; other site 189518008304 ABC-ATPase subunit interface; other site 189518008305 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 189518008306 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189518008307 Walker A/P-loop; other site 189518008308 ATP binding site [chemical binding]; other site 189518008309 Q-loop/lid; other site 189518008310 ABC transporter signature motif; other site 189518008311 Walker B; other site 189518008312 D-loop; other site 189518008313 H-loop/switch region; other site 189518008314 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189518008315 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 189518008316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 189518008317 Walker A/P-loop; other site 189518008318 ATP binding site [chemical binding]; other site 189518008319 Q-loop/lid; other site 189518008320 ABC transporter signature motif; other site 189518008321 Walker B; other site 189518008322 D-loop; other site 189518008323 H-loop/switch region; other site 189518008324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 189518008325 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 189518008326 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 189518008327 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518008328 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 189518008329 Walker A/P-loop; other site 189518008330 ATP binding site [chemical binding]; other site 189518008331 Q-loop/lid; other site 189518008332 ABC transporter signature motif; other site 189518008333 Walker B; other site 189518008334 D-loop; other site 189518008335 H-loop/switch region; other site 189518008336 Caspase domain; Region: Peptidase_C14; pfam00656 189518008337 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 189518008338 ketol-acid reductoisomerase; Provisional; Region: PRK05479 189518008339 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 189518008340 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 189518008341 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518008342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518008343 dimer interface [polypeptide binding]; other site 189518008344 putative CheW interface [polypeptide binding]; other site 189518008345 OsmC-like protein; Region: OsmC; cl00767 189518008346 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 189518008347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518008348 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 189518008349 putative active site [active] 189518008350 putative metal binding site [ion binding]; other site 189518008351 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 189518008352 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 189518008353 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 189518008354 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 189518008355 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 189518008356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 189518008357 dimer interface [polypeptide binding]; other site 189518008358 putative CheW interface [polypeptide binding]; other site 189518008359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189518008360 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518008361 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 189518008362 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 189518008363 DNA binding site [nucleotide binding] 189518008364 active site 189518008365 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 189518008366 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 189518008367 cobalamin binding residues [chemical binding]; other site 189518008368 putative BtuC binding residues; other site 189518008369 dimer interface [polypeptide binding]; other site 189518008370 acetyl-CoA synthetase; Provisional; Region: PRK00174 189518008371 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 189518008372 active site 189518008373 CoA binding site [chemical binding]; other site 189518008374 acyl-activating enzyme (AAE) consensus motif; other site 189518008375 AMP binding site [chemical binding]; other site 189518008376 acetate binding site [chemical binding]; other site 189518008377 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 189518008378 active site 189518008379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518008380 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 189518008381 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 189518008382 putative hydrophobic ligand binding site [chemical binding]; other site 189518008383 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 189518008384 extended (e) SDRs; Region: SDR_e; cd08946 189518008385 NAD(P) binding site [chemical binding]; other site 189518008386 active site 189518008387 substrate binding site [chemical binding]; other site 189518008388 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 189518008389 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 189518008390 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 189518008391 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 189518008392 putative acyl-acceptor binding pocket; other site 189518008393 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 189518008394 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 189518008395 ATP-grasp domain; Region: ATP-grasp; pfam02222 189518008396 FecR protein; Region: FecR; pfam04773 189518008397 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 189518008398 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518008399 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518008400 Domain of unknown function (DUF897); Region: DUF897; cl01312 189518008401 Alginate export; Region: Alginate_exp; pfam13372 189518008402 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 189518008403 NADH dehydrogenase; Region: NADHdh; cl00469 189518008404 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 189518008405 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl19689 189518008406 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 189518008407 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 189518008408 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 189518008409 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 189518008410 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 189518008411 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 189518008412 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 189518008413 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 189518008414 active site 189518008415 Phosphotransferase enzyme family; Region: APH; pfam01636 189518008416 Fructosamine kinase; Region: Fructosamin_kin; cl17579 189518008417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518008418 Walker A/P-loop; other site 189518008419 ATP binding site [chemical binding]; other site 189518008420 Q-loop/lid; other site 189518008421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 189518008422 ABC transporter signature motif; other site 189518008423 Walker B; other site 189518008424 D-loop; other site 189518008425 H-loop/switch region; other site 189518008426 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 189518008427 ABC-2 type transporter; Region: ABC2_membrane; cl17235 189518008428 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 189518008429 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 189518008430 quinone interaction residues [chemical binding]; other site 189518008431 active site 189518008432 catalytic residues [active] 189518008433 FMN binding site [chemical binding]; other site 189518008434 substrate binding site [chemical binding]; other site 189518008435 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 189518008436 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189518008437 catalytic core [active] 189518008438 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189518008439 active site 189518008440 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 189518008441 TrkA-N domain; Region: TrkA_N; pfam02254 189518008442 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 189518008443 Transcriptional regulators [Transcription]; Region: MarR; COG1846 189518008444 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 189518008445 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 189518008446 catalytic residues [active] 189518008447 dimer interface [polypeptide binding]; other site 189518008448 intracellular protease, PfpI family; Region: PfpI; TIGR01382 189518008449 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 189518008450 conserved cys residue [active] 189518008451 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 189518008452 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 189518008453 TrkA-N domain; Region: TrkA_N; pfam02254 189518008454 carbon storage regulator; Provisional; Region: PRK01712 189518008455 flagellar assembly protein FliW; Provisional; Region: PRK13285 189518008456 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 189518008457 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 189518008458 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 189518008459 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 189518008460 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 189518008461 FlgN protein; Region: FlgN; pfam05130 189518008462 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518008463 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518008464 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 189518008465 Intermediate filament protein; Region: Filament; pfam00038 189518008466 TRL-like protein family; Region: TRL; pfam13146 189518008467 Protein of unknown function (DUF423); Region: DUF423; pfam04241 189518008468 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 189518008469 active site 189518008470 Zn binding site [ion binding]; other site 189518008471 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518008472 Protein of unknown function (DUF1554); Region: DUF1554; pfam07588 189518008473 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 189518008474 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 189518008475 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 189518008476 trimer interface [polypeptide binding]; other site 189518008477 active site 189518008478 UDP-GlcNAc binding site [chemical binding]; other site 189518008479 lipid binding site [chemical binding]; lipid-binding site 189518008480 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 189518008481 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 189518008482 FAD binding pocket [chemical binding]; other site 189518008483 conserved FAD binding motif [chemical binding]; other site 189518008484 phosphate binding motif [ion binding]; other site 189518008485 beta-alpha-beta structure motif; other site 189518008486 NAD binding pocket [chemical binding]; other site 189518008487 Transcriptional Coactivator p15 (PC4); Region: PC4; pfam02229 189518008488 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 189518008489 nucleoside/Zn binding site; other site 189518008490 dimer interface [polypeptide binding]; other site 189518008491 catalytic motif [active] 189518008492 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14956 189518008493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518008494 Walker A motif; other site 189518008495 ATP binding site [chemical binding]; other site 189518008496 Walker B motif; other site 189518008497 arginine finger; other site 189518008498 hypothetical protein; Provisional; Region: PRK14624 189518008499 recombination protein RecR; Reviewed; Region: recR; PRK00076 189518008500 RecR protein; Region: RecR; pfam02132 189518008501 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 189518008502 putative active site [active] 189518008503 putative metal-binding site [ion binding]; other site 189518008504 tetramer interface [polypeptide binding]; other site 189518008505 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 189518008506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 189518008507 substrate binding pocket [chemical binding]; other site 189518008508 membrane-bound complex binding site; other site 189518008509 hinge residues; other site 189518008510 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 189518008511 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 189518008512 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518008513 ligand binding site [chemical binding]; other site 189518008514 seryl-tRNA synthetase; Provisional; Region: PRK05431 189518008515 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 189518008516 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 189518008517 dimer interface [polypeptide binding]; other site 189518008518 active site 189518008519 motif 1; other site 189518008520 motif 2; other site 189518008521 motif 3; other site 189518008522 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 189518008523 active site 189518008524 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 189518008525 Peptidase family M23; Region: Peptidase_M23; pfam01551 189518008526 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 189518008527 Protein of unknown function (DUF327); Region: DUF327; pfam03885 189518008528 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 189518008529 ParB-like nuclease domain; Region: ParB; smart00470 189518008530 KorB domain; Region: KorB; pfam08535 189518008531 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189518008532 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189518008533 P-loop; other site 189518008534 Magnesium ion binding site [ion binding]; other site 189518008535 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; cl17726 189518008536 hypothetical protein; Provisional; Region: PRK08262 189518008537 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 189518008538 putative metal binding site [ion binding]; other site 189518008539 pyruvate dehydrogenase E1 component, homodimeric type; Region: aceE; TIGR00759 189518008540 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 189518008541 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 189518008542 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 189518008543 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 189518008544 homodimer interface [polypeptide binding]; other site 189518008545 substrate-cofactor binding pocket; other site 189518008546 catalytic residue [active] 189518008547 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 189518008548 DNA polymerase III subunit delta'; Validated; Region: PRK08485 189518008549 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 189518008550 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 189518008551 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 189518008552 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 189518008553 FAD binding site [chemical binding]; other site 189518008554 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 189518008555 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 189518008556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189518008557 active site 189518008558 motif I; other site 189518008559 motif II; other site 189518008560 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 189518008561 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 189518008562 NAD(P) binding pocket [chemical binding]; other site 189518008563 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 189518008564 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 189518008565 domain interfaces; other site 189518008566 active site 189518008567 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 189518008568 dimer interface [polypeptide binding]; other site 189518008569 active site 189518008570 Schiff base residues; other site 189518008571 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 189518008572 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 189518008573 inhibitor-cofactor binding pocket; inhibition site 189518008574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518008575 catalytic residue [active] 189518008576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 189518008577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518008578 dimer interface [polypeptide binding]; other site 189518008579 phosphorylation site [posttranslational modification] 189518008580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008581 ATP binding site [chemical binding]; other site 189518008582 Mg2+ binding site [ion binding]; other site 189518008583 G-X-G motif; other site 189518008584 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518008585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518008586 active site 189518008587 phosphorylation site [posttranslational modification] 189518008588 intermolecular recognition site; other site 189518008589 dimerization interface [polypeptide binding]; other site 189518008590 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189518008591 DNA binding site [nucleotide binding] 189518008592 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 189518008593 substrate binding site [chemical binding]; other site 189518008594 active site 189518008595 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 189518008596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518008597 FeS/SAM binding site; other site 189518008598 HemN C-terminal domain; Region: HemN_C; pfam06969 189518008599 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 189518008600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 189518008601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518008602 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518008603 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518008604 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 189518008605 active site 189518008606 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 189518008607 active site 189518008608 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 189518008609 active site 189518008610 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189518008611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189518008612 P-loop; other site 189518008613 Magnesium ion binding site [ion binding]; other site 189518008614 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 189518008615 ParB-like nuclease domain; Region: ParB; smart00470 189518008616 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 189518008617 Acyltransferase family; Region: Acyl_transf_3; pfam01757 189518008618 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 189518008619 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 189518008620 ligand binding site [chemical binding]; other site 189518008621 flexible hinge region; other site 189518008622 short chain dehydrogenase; Provisional; Region: PRK07024 189518008623 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 189518008624 putative NAD(P) binding site [chemical binding]; other site 189518008625 active site 189518008626 Low molecular weight phosphatase family; Region: LMWPc; cd00115 189518008627 active site 189518008628 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 189518008629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 189518008630 short chain dehydrogenase; Provisional; Region: PRK06181 189518008631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 189518008632 NAD(P) binding site [chemical binding]; other site 189518008633 active site 189518008634 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 189518008635 putative hydrophobic ligand binding site [chemical binding]; other site 189518008636 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 189518008637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 189518008638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518008639 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518008640 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518008641 MoxR-like ATPases [General function prediction only]; Region: COG0714 189518008642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 189518008643 Walker A motif; other site 189518008644 ATP binding site [chemical binding]; other site 189518008645 Walker B motif; other site 189518008646 arginine finger; other site 189518008647 Protein of unknown function DUF58; Region: DUF58; pfam01882 189518008648 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 189518008649 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 189518008650 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 189518008651 metal ion-dependent adhesion site (MIDAS); other site 189518008652 von Willebrand factor type A domain; Region: VWA_2; pfam13519 189518008653 metal ion-dependent adhesion site (MIDAS); other site 189518008654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518008655 binding surface 189518008656 TPR motif; other site 189518008657 TPR repeat; Region: TPR_11; pfam13414 189518008658 Oxygen tolerance; Region: BatD; pfam13584 189518008659 RecX family; Region: RecX; cl00936 189518008660 heat shock protein 90; Provisional; Region: PRK05218 189518008661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518008662 ATP binding site [chemical binding]; other site 189518008663 Mg2+ binding site [ion binding]; other site 189518008664 G-X-G motif; other site 189518008665 Hsp90 protein; Region: HSP90; pfam00183 189518008666 U5 snRNP spliceosome subunit [RNA processing and modification]; Region: PRP8; COG5178 189518008667 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 189518008668 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 189518008669 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518008670 anti sigma factor interaction site; other site 189518008671 regulatory phosphorylation site [posttranslational modification]; other site 189518008672 ATP-NAD kinase; Region: NAD_kinase; cl01255 189518008673 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 189518008674 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 189518008675 Di-iron ligands [ion binding]; other site 189518008676 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 189518008677 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 189518008678 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518008679 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189518008680 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, MeaA-like subfamily; contains various methylmalonyl coenzyme A (CoA) mutase (MCM)-like proteins similar to the Streptomyces cinnamonensis MeaA, Methylobacterium extorquens MeaA...; Region: MM_CoA_mutase_MeaA; cd03681 189518008681 putative active site [active] 189518008682 putative substrate binding site [chemical binding]; other site 189518008683 putative coenzyme B12 binding site [chemical binding]; other site 189518008684 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 189518008685 B12 binding site [chemical binding]; other site 189518008686 cobalt ligand [ion binding]; other site 189518008687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518008688 S-adenosylmethionine binding site [chemical binding]; other site 189518008689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 189518008690 catalytic residues [active] 189518008691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 189518008692 binding surface 189518008693 Tetratricopeptide repeat; Region: TPR_16; pfam13432 189518008694 TPR motif; other site 189518008695 TPR repeat; Region: TPR_11; pfam13414 189518008696 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 189518008697 metal binding site [ion binding]; metal-binding site 189518008698 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 189518008699 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 189518008700 NAD(P) binding site [chemical binding]; other site 189518008701 homotetramer interface [polypeptide binding]; other site 189518008702 homodimer interface [polypeptide binding]; other site 189518008703 active site 189518008704 acyl carrier protein; Provisional; Region: acpP; PRK00982 189518008705 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 189518008706 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 189518008707 dimerization interface [polypeptide binding]; other site 189518008708 active site 189518008709 metal binding site [ion binding]; metal-binding site 189518008710 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 189518008711 dsRNA binding site [nucleotide binding]; other site 189518008712 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 189518008713 nudix motif; other site 189518008714 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 189518008715 active site 189518008716 dimer interface [polypeptide binding]; other site 189518008717 metal binding site [ion binding]; metal-binding site 189518008718 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 189518008719 Mechanosensitive ion channel; Region: MS_channel; pfam00924 189518008720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 189518008721 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 189518008722 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 189518008723 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 189518008724 acyl-activating enzyme (AAE) consensus motif; other site 189518008725 putative AMP binding site [chemical binding]; other site 189518008726 putative active site [active] 189518008727 putative CoA binding site [chemical binding]; other site 189518008728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518008729 dimerization interface [polypeptide binding]; other site 189518008730 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518008731 cyclase homology domain; Region: CHD; cd07302 189518008732 nucleotidyl binding site; other site 189518008733 metal binding site [ion binding]; metal-binding site 189518008734 dimer interface [polypeptide binding]; other site 189518008735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518008736 S-adenosylmethionine binding site [chemical binding]; other site 189518008737 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 189518008738 putative active site [active] 189518008739 putative metal binding site [ion binding]; other site 189518008740 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 189518008741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 189518008742 active site 189518008743 motif I; other site 189518008744 motif II; other site 189518008745 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518008746 active site 189518008747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518008748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518008749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 189518008750 dimerization interface [polypeptide binding]; other site 189518008751 putative DNA binding site [nucleotide binding]; other site 189518008752 putative Zn2+ binding site [ion binding]; other site 189518008753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518008754 S-adenosylmethionine binding site [chemical binding]; other site 189518008755 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 189518008756 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 189518008757 homotetramer interface [polypeptide binding]; other site 189518008758 ligand binding site [chemical binding]; other site 189518008759 catalytic site [active] 189518008760 NAD binding site [chemical binding]; other site 189518008761 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 189518008762 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 189518008763 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 189518008764 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 189518008765 substrate binding pocket [chemical binding]; other site 189518008766 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 189518008767 B12 binding site [chemical binding]; other site 189518008768 cobalt ligand [ion binding]; other site 189518008769 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 189518008770 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 189518008771 active site 189518008772 ADP/pyrophosphate binding site [chemical binding]; other site 189518008773 dimerization interface [polypeptide binding]; other site 189518008774 allosteric effector site; other site 189518008775 fructose-1,6-bisphosphate binding site; other site 189518008776 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189518008777 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 189518008778 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 189518008779 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518008780 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 189518008781 homohexameric interface [polypeptide binding]; other site 189518008782 feedback inhibition sensing region; other site 189518008783 nucleotide binding site [chemical binding]; other site 189518008784 N-acetyl-L-glutamate binding site [chemical binding]; other site 189518008785 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 189518008786 classical (c) SDRs; Region: SDR_c; cd05233 189518008787 NAD(P) binding site [chemical binding]; other site 189518008788 active site 189518008789 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 189518008790 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 189518008791 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 189518008792 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 189518008793 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 189518008794 catalytic triad [active] 189518008795 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518008796 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 189518008797 cyclase homology domain; Region: CHD; cd07302 189518008798 nucleotidyl binding site; other site 189518008799 metal binding site [ion binding]; metal-binding site 189518008800 dimer interface [polypeptide binding]; other site 189518008801 Tetratricopeptide repeat; Region: TPR_2; pfam07719 189518008802 classical (c) SDRs; Region: SDR_c; cd05233 189518008803 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 189518008804 NAD(P) binding site [chemical binding]; other site 189518008805 active site 189518008806 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 189518008807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 189518008808 active site 189518008809 DNA binding site [nucleotide binding] 189518008810 Int/Topo IB signature motif; other site 189518008811 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 189518008812 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 189518008813 ADP binding site [chemical binding]; other site 189518008814 magnesium binding site [ion binding]; other site 189518008815 putative shikimate binding site; other site 189518008816 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 189518008817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 189518008818 Zn2+ binding site [ion binding]; other site 189518008819 Mg2+ binding site [ion binding]; other site 189518008820 CheD chemotactic sensory transduction; Region: CheD; cl00810 189518008821 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 189518008822 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 189518008823 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518008824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189518008825 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518008826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518008827 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 189518008828 anti sigma factor interaction site; other site 189518008829 regulatory phosphorylation site [posttranslational modification]; other site 189518008830 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 189518008831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 189518008832 dimerization interface [polypeptide binding]; other site 189518008833 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 189518008834 FecR protein; Region: FecR; pfam04773 189518008835 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 189518008836 HAMP domain; Region: HAMP; pfam00672 189518008837 FecR protein; Region: FecR; pfam04773 189518008838 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 189518008839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 189518008840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 189518008841 DNA binding residues [nucleotide binding] 189518008842 hypothetical protein; Provisional; Region: PRK10030 189518008843 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 189518008844 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 189518008845 catalytic core [active] 189518008846 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 189518008847 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 189518008848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 189518008849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 189518008850 homodimer interface [polypeptide binding]; other site 189518008851 catalytic residue [active] 189518008852 cobyric acid synthase; Provisional; Region: PRK00784 189518008853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189518008854 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 189518008855 catalytic triad [active] 189518008856 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 189518008857 homotrimer interface [polypeptide binding]; other site 189518008858 Walker A motif; other site 189518008859 GTP binding site [chemical binding]; other site 189518008860 Walker B motif; other site 189518008861 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 189518008862 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 189518008863 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 189518008864 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 189518008865 catalytic triad [active] 189518008866 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 189518008867 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 189518008868 homodimer interface [polypeptide binding]; other site 189518008869 Walker A motif; other site 189518008870 ATP binding site [chemical binding]; other site 189518008871 hydroxycobalamin binding site [chemical binding]; other site 189518008872 Walker B motif; other site 189518008873 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 189518008874 active site 189518008875 SAM binding site [chemical binding]; other site 189518008876 homodimer interface [polypeptide binding]; other site 189518008877 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 189518008878 active site 189518008879 SAM binding site [chemical binding]; other site 189518008880 homodimer interface [polypeptide binding]; other site 189518008881 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 189518008882 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 189518008883 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 189518008884 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 189518008885 nudix motif; other site 189518008886 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 189518008887 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 189518008888 active site 189518008889 SAM binding site [chemical binding]; other site 189518008890 homodimer interface [polypeptide binding]; other site 189518008891 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 189518008892 active site 189518008893 putative homodimer interface [polypeptide binding]; other site 189518008894 SAM binding site [chemical binding]; other site 189518008895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518008896 S-adenosylmethionine binding site [chemical binding]; other site 189518008897 Precorrin-8X methylmutase; Region: CbiC; pfam02570 189518008898 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 189518008899 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 189518008900 FAD binding pocket [chemical binding]; other site 189518008901 conserved FAD binding motif [chemical binding]; other site 189518008902 phosphate binding motif [ion binding]; other site 189518008903 beta-alpha-beta structure motif; other site 189518008904 NAD binding pocket [chemical binding]; other site 189518008905 Protein of unknown function (DUF3209); Region: DUF3209; pfam11483 189518008906 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 189518008907 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 189518008908 putative active site [active] 189518008909 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 189518008910 putative active site [active] 189518008911 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 189518008912 dimer interface [polypeptide binding]; other site 189518008913 [2Fe-2S] cluster binding site [ion binding]; other site 189518008914 CoA binding domain; Region: CoA_binding; cl17356 189518008915 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 189518008916 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 189518008917 NAD(P) binding site [chemical binding]; other site 189518008918 homodimer interface [polypeptide binding]; other site 189518008919 substrate binding site [chemical binding]; other site 189518008920 active site 189518008921 Sulfate transporter family; Region: Sulfate_transp; cl19250 189518008922 heat shock protein HtpX; Provisional; Region: PRK05457 189518008923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 189518008924 active site 189518008925 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189518008926 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 189518008927 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189518008928 protein binding site [polypeptide binding]; other site 189518008929 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 189518008930 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 189518008931 protein binding site [polypeptide binding]; other site 189518008932 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 189518008933 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 189518008934 metal binding site 2 [ion binding]; metal-binding site 189518008935 putative DNA binding helix; other site 189518008936 metal binding site 1 [ion binding]; metal-binding site 189518008937 dimer interface [polypeptide binding]; other site 189518008938 structural Zn2+ binding site [ion binding]; other site 189518008939 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 189518008940 heme binding pocket [chemical binding]; other site 189518008941 heme ligand [chemical binding]; other site 189518008942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518008943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 189518008944 putative substrate translocation pore; other site 189518008945 Protein of unknown function (DUF1564); Region: DUF1564; pfam07600 189518008946 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 189518008947 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 189518008948 N-terminal plug; other site 189518008949 ligand-binding site [chemical binding]; other site 189518008950 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 189518008951 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 189518008952 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 189518008953 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 189518008954 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 189518008955 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 189518008956 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 189518008957 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 189518008958 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 189518008959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 189518008960 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518008961 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 189518008962 catalytic triad [active] 189518008963 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518008964 Protein of unknown function (DUF1574); Region: DUF1574; pfam07611 189518008965 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 189518008966 homodimer interface [polypeptide binding]; other site 189518008967 metal binding site [ion binding]; metal-binding site 189518008968 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 189518008969 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 189518008970 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 189518008971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518008972 S-adenosylmethionine binding site [chemical binding]; other site 189518008973 Protease prsW family; Region: PrsW-protease; pfam13367 189518008974 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 189518008975 Ribosomal protein L33; Region: Ribosomal_L33; pfam00471 189518008976 putative transposase OrfB; Reviewed; Region: PHA02517 189518008977 Integrase core domain; Region: rve; pfam00665 189518008978 Integrase core domain; Region: rve_3; pfam13683 189518008979 Transposase; Region: HTH_Tnp_1; pfam01527 189518008980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189518008981 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518008982 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518008983 Helix-turn-helix domain; Region: HTH_18; pfam12833 189518008984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 189518008985 Transposase; Region: HTH_Tnp_1; pfam01527 189518008986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189518008987 putative transposase OrfB; Reviewed; Region: PHA02517 189518008988 Integrase core domain; Region: rve; pfam00665 189518008989 Integrase core domain; Region: rve_3; pfam13683 189518008990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518008991 active site 189518008992 phosphorylation site [posttranslational modification] 189518008993 intermolecular recognition site; other site 189518008994 dimerization interface [polypeptide binding]; other site 189518008995 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 189518008996 nucleotidyl binding site; other site 189518008997 metal binding site [ion binding]; metal-binding site 189518008998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 189518008999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518009000 metal binding site [ion binding]; metal-binding site 189518009001 active site 189518009002 I-site; other site 189518009003 Cache domain; Region: Cache_1; pfam02743 189518009004 Cache domain; Region: Cache_1; pfam02743 189518009005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 189518009006 metal binding site [ion binding]; metal-binding site 189518009007 active site 189518009008 I-site; other site 189518009009 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 189518009010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 189518009011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518009012 dimer interface [polypeptide binding]; other site 189518009013 phosphorylation site [posttranslational modification] 189518009014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518009015 ATP binding site [chemical binding]; other site 189518009016 Mg2+ binding site [ion binding]; other site 189518009017 G-X-G motif; other site 189518009018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518009019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518009020 active site 189518009021 phosphorylation site [posttranslational modification] 189518009022 intermolecular recognition site; other site 189518009023 dimerization interface [polypeptide binding]; other site 189518009024 FecR protein; Region: FecR; pfam04773 189518009025 Patatin-like phospholipase; Region: Patatin; pfam01734 189518009026 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 189518009027 Na binding site [ion binding]; other site 189518009028 putative glycosylation site [posttranslational modification]; other site 189518009029 putative glycosylation site [posttranslational modification]; other site 189518009030 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 189518009031 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 189518009032 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 189518009033 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 189518009034 active site 189518009035 nucleophile elbow; other site 189518009036 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 189518009037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 189518009038 putative substrate translocation pore; other site 189518009039 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 189518009040 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 189518009041 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 189518009042 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 189518009043 active site 189518009044 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 189518009045 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 189518009046 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 189518009047 active site 189518009048 Lecithin:cholesterol acyltransferase; Region: LCAT; pfam02450 189518009049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 189518009050 Putative lysophospholipase; Region: Hydrolase_4; cl19140 189518009051 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 189518009052 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 189518009053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 189518009054 catalytic residue [active] 189518009055 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 189518009056 diiron binding motif [ion binding]; other site 189518009057 YhhN-like protein; Region: YhhN; pfam07947 189518009058 Integral membrane protein TerC family; Region: TerC; cl10468 189518009059 Integral membrane protein TerC family; Region: TerC; cl10468 189518009060 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 189518009061 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 189518009062 heterodimer interface [polypeptide binding]; other site 189518009063 substrate interaction site [chemical binding]; other site 189518009064 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 189518009065 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 189518009066 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 189518009067 active site 189518009068 substrate binding site [chemical binding]; other site 189518009069 coenzyme B12 binding site [chemical binding]; other site 189518009070 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 189518009071 B12 binding site [chemical binding]; other site 189518009072 cobalt ligand [ion binding]; other site 189518009073 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 189518009074 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 189518009075 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 189518009076 Walker A; other site 189518009077 G1 box; other site 189518009078 GTP/Mg2+ binding site [chemical binding]; other site 189518009079 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 189518009080 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 189518009081 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 189518009082 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 189518009083 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 189518009084 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 189518009085 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 189518009086 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 189518009087 putative active site [active] 189518009088 putative metal binding site [ion binding]; other site 189518009089 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 189518009090 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 189518009091 active site 189518009092 FMN binding site [chemical binding]; other site 189518009093 substrate binding site [chemical binding]; other site 189518009094 3Fe-4S cluster binding site [ion binding]; other site 189518009095 Yip1 domain; Region: Yip1; pfam04893 189518009096 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 189518009097 active site 189518009098 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 189518009099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 189518009100 putative active site [active] 189518009101 heme pocket [chemical binding]; other site 189518009102 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 189518009103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518009104 dimer interface [polypeptide binding]; other site 189518009105 phosphorylation site [posttranslational modification] 189518009106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518009107 ATP binding site [chemical binding]; other site 189518009108 Mg2+ binding site [ion binding]; other site 189518009109 G-X-G motif; other site 189518009110 short chain dehydrogenase; Provisional; Region: PRK07454 189518009111 classical (c) SDRs; Region: SDR_c; cd05233 189518009112 NAD(P) binding site [chemical binding]; other site 189518009113 active site 189518009114 methylthioribulose-1-phosphate dehydratase; Region: salvage_mtnB; TIGR03328 189518009115 intersubunit interface [polypeptide binding]; other site 189518009116 active site 189518009117 Zn2+ binding site [ion binding]; other site 189518009118 Cupin domain; Region: Cupin_2; cl17218 189518009119 translation elongation factor P; Region: efp; TIGR00038 189518009120 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 189518009121 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 189518009122 RNA binding site [nucleotide binding]; other site 189518009123 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 189518009124 RNA binding site [nucleotide binding]; other site 189518009125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518009126 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518009127 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518009128 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 189518009129 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 189518009130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 189518009131 FeS/SAM binding site; other site 189518009132 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 189518009133 putative transposase OrfB; Reviewed; Region: PHA02517 189518009134 Integrase core domain; Region: rve; pfam00665 189518009135 Integrase core domain; Region: rve_3; pfam13683 189518009136 Transposase; Region: HTH_Tnp_1; pfam01527 189518009137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189518009138 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 189518009139 Predicted membrane protein [Function unknown]; Region: COG1238 189518009140 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518009141 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 189518009142 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 189518009143 active site 189518009144 dimer interface [polypeptide binding]; other site 189518009145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 189518009146 S-adenosylmethionine binding site [chemical binding]; other site 189518009147 SET domain; Region: SET; pfam00856 189518009148 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 189518009149 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 189518009150 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 189518009151 alanine racemase; Reviewed; Region: alr; PRK00053 189518009152 active site 189518009153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 189518009154 dimer interface [polypeptide binding]; other site 189518009155 substrate binding site [chemical binding]; other site 189518009156 catalytic residues [active] 189518009157 Phosphate acyltransferases; Region: PlsC; smart00563 189518009158 putative acyl-acceptor binding pocket; other site 189518009159 MgtE intracellular N domain; Region: MgtE_N; cl15244 189518009160 Sec24-related protein; Provisional; Region: PTZ00395 189518009161 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 189518009162 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 189518009163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 189518009164 dimer interface [polypeptide binding]; other site 189518009165 phosphorylation site [posttranslational modification] 189518009166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 189518009167 ATP binding site [chemical binding]; other site 189518009168 Mg2+ binding site [ion binding]; other site 189518009169 G-X-G motif; other site 189518009170 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 189518009171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 189518009172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 189518009173 catalytic residue [active] 189518009174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 189518009175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 189518009176 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 189518009177 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 189518009178 substrate binding site [chemical binding]; other site 189518009179 ligand binding site [chemical binding]; other site 189518009180 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 189518009181 substrate binding site [chemical binding]; other site 189518009182 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 189518009183 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 189518009184 ligand binding site [chemical binding]; other site 189518009185 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 189518009186 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 189518009187 motif 1; other site 189518009188 dimer interface [polypeptide binding]; other site 189518009189 active site 189518009190 motif 2; other site 189518009191 motif 3; other site 189518009192 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 189518009193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 189518009194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 189518009195 active site 189518009196 phosphorylation site [posttranslational modification] 189518009197 intermolecular recognition site; other site 189518009198 dimerization interface [polypeptide binding]; other site 189518009199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 189518009200 DNA binding site [nucleotide binding] 189518009201 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 189518009202 aromatic arch; other site 189518009203 DCoH dimer interaction site [polypeptide binding]; other site 189518009204 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 189518009205 DCoH tetramer interaction site [polypeptide binding]; other site 189518009206 substrate binding site [chemical binding]; other site 189518009207 Pfg27; Region: Pfg27; cl07736 189518009208 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 189518009209 Resistance to inhibitors of cholinesterase homologue 3; Region: RIC3; pfam15361 189518009210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 189518009211 Transposase; Region: DEDD_Tnp_IS110; pfam01548 189518009212 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 189518009213 Transposase; Region: HTH_Tnp_1; pfam01527 189518009214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 189518009215 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 189518009216 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 189518009217 pyruvate kinase; Provisional; Region: PRK05826 189518009218 domain interfaces; other site 189518009219 active site 189518009220 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 189518009221 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 189518009222 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 189518009223 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 189518009224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 189518009225 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 189518009226 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 189518009227 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 189518009228 P-loop; other site 189518009229 Magnesium ion binding site [ion binding]; other site 189518009230 ParB-like nuclease domain; Region: ParB; smart00470 189518009231 Helix-turn-helix domain; Region: HTH_36; pfam13730